keyword
https://read.qxmd.com/read/38248085/anemia-and-iron-deficiency-predict-all-cause-mortality-in-patients-with-heart-failure-and-preserved-ejection-fraction-6-year-follow-up-study
#1
JOURNAL ARTICLE
Fatoş Dilan Köseoğlu, Bülent Özlek
AIMS: The aim of this study was to assess the prevalence of anemia and iron deficiency in patients with heart failure with preserved ejection fraction (HFpEF) and its impact on clinical outcomes. METHODS: We retrospectively analyzed 212 patients with HFpEF and identified anemia as a serum hemoglobin level of less than 13 g/dL in men and less than 12 g/dL in women. Additionally, ID was defined as a serum ferritin concentration < 100 ng/mL or 100-299 ng/mL with transferrin saturation < 20%...
January 18, 2024: Diagnostics
https://read.qxmd.com/read/38206230/plasma-ferritin-levels-incident-heart%C3%A2-failure-and-cardiac-structure%C3%A2-and%C3%A2-function-the-aric-study
#2
JOURNAL ARTICLE
Iman A F Aboelsaad, Brian L Claggett, Victoria Arthur, Pranav Dorbala, Kunihiro Matsushita, Brandon W Lennep, Bing Yu, Pamela L Lutsey, Chiadi E Ndumele, Youssef M K Farag, Amil M Shah, Leo F Buckley
BACKGROUND: Whether iron deficiency contributes to incident heart failure (HF) and cardiac dysfunction has important implications given the prevalence of iron deficiency and the availability of several therapeutics for iron repletion. OBJECTIVES: The aim of this study was to estimate the associations of plasma ferritin level with incident HF overall, HF phenotypes, and cardiac structure and function measures in older adults. METHODS: Participants in the ongoing, longitudinal ARIC (Atherosclerosis Risk In Communities) study who were free of prevalent HF and anemia were studied...
March 2024: JACC. Heart Failure
https://read.qxmd.com/read/38200643/age-stratified-sex-differences-in-heart-failure-with-preserved-ejection-fraction-among-adult-hospitalizations
#3
JOURNAL ARTICLE
Mulubrhan F Mogos, James M Muchira, Chorong Park, Sarah Osmundson, Mariann R Piano
BACKGROUND: There is evidence that heart failure with preserved ejection fraction (HFpEF)-related hospitalizations are increasing in the United States. However, there is a lack of knowledge about HFpEF-related hospitalizations among younger adults. OBJECTIVE: The aims of this study were to perform a retrospective analysis using the Nationwide Inpatient Sample and to examine age-stratified sex differences in the prevalence, correlates, and outcomes of HFpEF-related hospitalization across the adult life span...
January 11, 2024: Journal of Cardiovascular Nursing
https://read.qxmd.com/read/37794956/contributions-of-anemia-to-exercise-intolerance-in-heart-failure-with-preserved-ejection-fraction-an-exercise-stress-echocardiographic-study
#4
JOURNAL ARTICLE
Ayami Naito, Masaru Obokata, Kazuki Kagami, Tomonari Harada, Hidemi Sorimachi, Naoki Yuasa, Yuki Saito, Toshimitsu Kato, Naoki Wada, Takeshi Adachi, Hideki Ishii
AIMS: Anemia is common in patients with heart failure with preserved ejection fraction (HFpEF) and is associated with exercise intolerance. However, there are limited data on how anemia contributes to reduced exercise capacity in patients with HFpEF. We aimed to characterize exercise capacity, cardiovascular and ventilatory reserve, and the oxygen (O2 ) pathway in anemic patients with HFpEF. METHODS: A total of 238 patients with HFpEF and 248 dyspneic patients without HF underwent ergometry exercise stress echocardiography with simultaneous expired gas analysis...
October 2023: IJC Heart & Vasculature
https://read.qxmd.com/read/37767373/the-prevalence-of-cardiorenal-anemia-syndrome-among-patients-with-heart-failure-and-its-association-with-all-cause-hospitalizations-a-retrospective-single-center-study-from-the-middle-east
#5
JOURNAL ARTICLE
Yosef Manla, Obada Kholoki, Feras Bader, Oshin Kanwar, Emna Abidi, Wasim S El Nekidy, Fadi Hijazi, Nizar Attallah
BACKGROUND AND AIM: Little is known about the burden of cardiorenal syndrome (CRS) and cardiorenal anemia syndrome (CRAS) in the Middle East Region. Furthermore, whether the occurrence rates of CRAS differ across heart failure (HF) phenotypes is not widely investigated. We aimed to examine the prevalence of CRS and CRAS in patients with HF, compare characteristics of patients with CRAS-HFrEF vs. CRAS-HFpEF, and investigate anemia association with 1-year all-cause hospitalizations. METHODS: HF patients who visited a multidisciplinary HF clinic at a single center between 10-2015 and 06-2022 ( n  = 968) were retrospectively included...
2023: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/37734333/biomarker-phenotypes-in-heart-failure-with-preserved-ejection-fraction-using-hierarchical-clustering-a-pilot-study
#6
JOURNAL ARTICLE
Valentina Mitic, Dijana Stojanovic, Marina Deljanin-Ilic, Dejan Petrovic, Aleksandra Ignjatovic, Jelena Milenkovic
OBJECTIVES: We hypothesized the existence of distinct phenotype-based groups within the very heterogeneous population of patients of heart failure with preserved ejection fraction (HFpEF) and using an unsupervised hierarchical clustering applied to plasma concentration of various biomarkers. We sought to characterize them as "biomarker phenotypes" and to conclude differences in their overall characteristics. SUBJECTS AND METHODS: A cross-sectional study was conducted on 75 patients with HFpEF...
September 21, 2023: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://read.qxmd.com/read/37623468/phenotype-specific-outcome-and-treatment-response-in-heart-failure-with-preserved-ejection-fraction-with-comorbid-hypertension-and-diabetes-a-12-month-multicentered-prospective-cohort-study
#7
JOURNAL ARTICLE
Ngoc-Thanh-Van Nguyen, Hoai-An Nguyen, Hai Hoang Nguyen, Binh Quang Truong, Hoa Ngoc Chau
Despite evidence of SGLT2 inhibitors in improving cardiovascular outcomes of heart failure with preserved ejection fraction (HFpEF), the heterogenous mechanism and characteristic multimorbidity of HFpEF require a phenotypic approach. Metabolic phenotype, one common HFpEF phenotype, has various presentations and prognoses worldwide. We aimed to identify different phenotypes of hypertensive-diabetic HFpEF, their phenotype-related outcomes, and treatment responses. The primary endpoint was time to the first event of all-cause mortality or hospitalization for heart failure (HHF)...
July 31, 2023: Journal of Personalized Medicine
https://read.qxmd.com/read/37568493/hypertensive-heart-failure
#8
REVIEW
Filippos Triposkiadis, Pantelis Sarafidis, Alexandros Briasoulis, Dimitrios E Magouliotis, Thanos Athanasiou, John Skoularigis, Andrew Xanthopoulos
Despite overwhelming epidemiological evidence, the contribution of hypertension (HTN) to heart failure (HF) development has been undermined in current clinical practice. This is because approximately half of HF patients have been labeled as suffering from HF with preserved left ventricular (LV) ejection fraction (EF) (HFpEF), with HTN, obesity, and diabetes mellitus (DM) being considered virtually equally responsible for its development. However, this suggestion is obviously inaccurate, since HTN is by far the most frequent and devastating morbidity present in HFpEF...
August 2, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37511587/a-systematic-review-of-the-effect-of-vericiguat-on-patients-with-heart-failure
#9
REVIEW
Urjosee Sahana, Markus Wehland, Ulf Simonsen, Herbert Schulz, Daniela Grimm
Despite recent advances in heart failure (HF) therapy, the risk of cardiovascular (CV) mortality, morbidity, and HF hospitalization (HFH) are major challenges in HF treatment. We aimed to review the potential of vericiguat as a treatment option for HF. A systematic literature review was performed using the PubMed database and ClinicalTrials.gov. Four randomized controlled trials were identified, which study the safety and efficacy of vericiguat in HF patients. Vericiguat activates soluble guanylate cyclase (sGC) by binding to the beta-subunit, bypassing the requirement for NO-induced activation...
July 23, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37396430/characterizing-heart%C3%A2-failure-with-preserved-ejection-fraction-in-end-stage%C3%A2-liver-disease-and-liver%C3%A2-transplant-outcomes
#10
JOURNAL ARTICLE
Won-Jung Shin, Hye-Mee Kwon, Sung-Hoon Kim, Hwa-Young Jang, Ji-Young Kim, Jae-Hwan Kim, Kyoung-Sun Kim, Young-Jin Moon, In-Gu Jun, Jun-Gol Song, Gyu-Sam Hwang
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) and its risk factors are increasingly recognized in patients with end-stage liver disease (ESLD). OBJECTIVES: The aim of this study was to characterize HFpEF and identify relevant risk factors in patients with ESLD. Additionally, the prognostic impact of high-probability HFpEF on post-liver transplantation (LT) mortality was investigated. METHODS: Patients with ESLD prospectively enrolled from the Asan LT Registry between 2008 and 2019 were divided into groups with low (scores of 0 and 1), intermediate (scores of 2-4), and high (scores of 5 and 6) probability using the Heart Failure Association-PEFF diagnostic score for HFpEF...
June 2023: JACC Asia
https://read.qxmd.com/read/37222949/sex-differences-in-cardiorenal-syndrome-insights-from-cardioren-registry
#11
REVIEW
Marta Cobo Marcos, Rafael de la Espriella, Jara Gayán Ordás, Isabel Zegrí, Antonia Pomares, Pau Llácer, Aleix Fort, Adriana Rodríguez Chavarri, Ana Méndez, Zorba Blázquez, Pedro Caravaca Pérez, Jorge Rubio Gracia, Alejandro Recio-Mayoral, Jose Manuel García Pinilla, Maria Jose Soler, Ramón Garrido González, Jose Luis Górriz, Miguel González Rico, Almudena Castro, Julio Núñez
PURPOSE OF THE WORK: Although sex-specific differences in heart failure (HF) or kidney disease (KD) have been analyzed separately, the predominant cardiorenal phenotype by sex has not been described. This study aims to explore the sex-related differences in cardiorenal syndrome (CRS) in a contemporary cohort of outpatients with HF. FINDINGS: An analysis of the Cardiorenal Spanish registry (CARDIOREN) was performed. CARDIOREN Registry is a prospective multicenter observational registry including 1107 chronic ambulatory HF patients (37% females) from 13 Spanish HF clinics...
May 24, 2023: Current Heart Failure Reports
https://read.qxmd.com/read/37172316/comprehensive-characterization-of-non-cardiac-comorbidities-in-acute-heart-failure-an-analysis-of-esc-hfa-eurobservational-research-programme-heart-failure-long-term-registry
#12
JOURNAL ARTICLE
Ovidiu Chioncel, Lina Benson, Maria G Crespo-Leiro, Stefan D Anker, Andrew J S Coats, Gerasimos Filippatos, Theresa McDonagh, Cornelia Margineanu, Alexandre Mebazaa, Marco Metra, Massimo F Piepoli, Marianna Adamo, Giuseppe M C Rosano, Frank Ruschitzka, Gianluigi Savarese, Petar Seferovic, Maurizio Volterrani, Roberto Ferrari, Aldo P Maggioni, Lars H Lund
AIMS: To evaluate the prevalence and associations of non-cardiac comorbidities (NCCs) with in-hospital and post-discharge outcomes in acute heart failure (AHF) across the ejection fraction (EF) spectrum. METHODS AND RESULTS: The 9326 AHF patients from European Society of Cardiology (ESC)-Heart Failure Association (HFA)-EURObservational Research Programme Heart Failure Long-Term Registry had complete information for the following 12 NCCs: anaemia, chronic obstructive pulmonary disease (COPD), diabetes, depression, hepatic dysfunction, renal dysfunction, malignancy, Parkinson's disease, peripheral vascular disease (PVD), rheumatoid arthritis, sleep apnoea, and stroke/transient ischaemic attack (TIA)...
September 20, 2023: European Journal of Preventive Cardiology
https://read.qxmd.com/read/37118820/association-of-complication-of-type-2-diabetes-mellitus-with-hemodynamics-and-exercise-capacity-in-patients-with-heart-failure-with-preserved-ejection-fraction-a-case-control-study-in-individuals-aged-65-80%C3%A2-years
#13
JOURNAL ARTICLE
Yousuke Sugita, Katsuhiko Ito, Yui Yoshioka, Satoshi Sakai
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a frequently observed complication in patients with heart failure with preserved ejection fraction (HFpEF). Although a characteristic finding in such patients is a decrease in objective exercise capacity represented by peak oxygen uptake (peakVO2 ), exercise capacity and its predictors in HFpEF with T2DM remain not clearly understood. This case-control study aimed to investigate the association between exercise capacity and hemodynamics indicators and T2DM comorbidity in patients with HFpEF aged 65-80 years...
April 28, 2023: Cardiovascular Diabetology
https://read.qxmd.com/read/36974746/health-status-across-major-subgroup-of-patients-with-heart-failure-and-preserved-ejection-fraction
#14
JOURNAL ARTICLE
Tariq Jamal Siddiqi, Stefan D Anker, Gerasimos Filippatos, João Pedro Ferreira, Stuart J Pocock, Michael Böhm, Martina Brueckmann, Vijay K Chopra, Tomoko Iwata, James Januzzi, Ileana L Piña, Piotr Ponikowski, Michele Senni, Ola Vedin, Subodh Verma, Yuhui Zhang, Faiez Zannad, Milton Packer, Javed Butler
AIMS: There are limited data on health status and changes in it over time across major subgroups of patients with heart failure and preserved ejection fraction (HFpEF), including ejection fraction spectrum, age, sex, region, body mass index (BMI), and comorbidities including diabetes, chronic kidney disease (CKD), anemia, and atrial fibrillation/flutter. METHODS AND RESULTS: In the EMPEROR-Preserved trial, Kansas City Cardiomyopathy Questionnaire (KCCQ) was assessed at baseline, 12-, 32- and 52-weeks...
March 28, 2023: European Journal of Heart Failure
https://read.qxmd.com/read/36895081/association-between-anemia-status-and-the-risk-of-different-types-of-heart-failure-a-rcscd-tcm-study-in-china
#15
JOURNAL ARTICLE
Tongyao Ni, Yijia Liu, Mengnan Huang, Mei Ma, Lin Li, Chunjie Li, Rongrong Yang, Chunquan Yu
We investigated the association between anemia status and the risk of heart failure (HF) in patients with coronary heart disease (CHD) based on a multi-center, large-sample and retrospective cross-sectional study including 89,207 patients. Heart failure was categorized as HF with reduced ejection fraction (HFrEF), HF with preserved ejection fraction (HFpEF), and HF with mid-range ejection fraction (HFmrEF). In multi-adjusted models, compared with patients without anemia, mild anemia (odds ratio [OR] 1.71; 95% confidence interval [CI] 1...
March 9, 2023: Angiology
https://read.qxmd.com/read/36884155/the-predictive-value-of-precipitating-factors-on-clinical-outcomes-in-hospitalized-patients-with-decompensated-heart-failure-insights-from-the-egyptian-cohort-in-the-european-society-of-cardiology-heart-failure-long-term-registry
#16
JOURNAL ARTICLE
Ahmed Bendary, Mahmoud Hassanein, Mohamed Bendary, Ahmed Smman, Ahmed Hassanin, Mostafa Elwany
BACKGROUND: Knowledge of the frequency of precipitating factors for acute heart failure (AHF) is important (either new-onset heart failure [NOHF] or worsening heart failure [WHF]), as this can guide strategies for prevention and treatment. Most data come only from Western Europe and North America; nevertheless, geographic differences do exist. We set out to study the prevalence of precipitating factors of AHF and their connection to patient characteristics and in-hospital and long-term mortality in patients from Egypt hospitalized for decompensated HF...
March 8, 2023: Egyptian Heart Journal: EHJ
https://read.qxmd.com/read/36870449/clinical-profiling-of-end-stage-heart-failure-with-preserved-ejection-fraction-the-national-readmission-database
#17
JOURNAL ARTICLE
Reza Mohebi, Yuxi Liu, Sean P Murphy, Hanna K Gaggin, James L Januzzi
BACKGROUND: End-stage (Stage D) heart failure with preserved ejection fraction (HFpEF) is a poorly characterized syndrome that has heterogeneous underlying pathophysiology. A better characterization of the various clinical profiles of Stage D HFpEF is needed. METHOD: 1066 patients with Stage D HFpEF were selected from National Readmission Database. A Bayesian clustering algorithm based on a Dirichlet process mixture model was implemented. Cox proportional hazard regression model was used to relate the risk of in-hospital mortality with each identified clinical cluster...
March 2, 2023: International Journal of Cardiology
https://read.qxmd.com/read/36407262/iron-deficiency-in-heart-failure-what-do-we-know-so-far
#18
REVIEW
Amr Elkammash, Rasha M Farahat, Aya Al Sattouf, Julius Lenaerts, Khin Yadanar Maung, Aayesha Khatri
Iron is vital for multiple biological processes in the human body. Heart failure (HF) patients are at a high risk of becoming iron deficient. Iron deficiency is a marker of severe HF and an ominous sign of poor outcomes. Iron deficiency can be absolute (low iron stores) or functional (improper functioning in the metabolic processes). The European Society of Cardiology recommends routine screening of iron stores in HF patients using ferritin and transferrin saturation. It advises iron replacement in deficient patients irrespective of the presence of anemia...
October 2022: Curēus
https://read.qxmd.com/read/36205772/initial-experience-of-hypoxia-inducible-factor-prolyl-hydroxylase-inhibitors-in-patients-with-heart-failure-and-renal-anemia
#19
JOURNAL ARTICLE
Makiko Nakamura, Teruhiko Imamura, Mitsuo Sobajima, Koichiro Kinugawa
Hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitors might improve renal anemia maintaining fewer cardiovascular complications. However, its safety and efficacy, as well as its impact on inflammatory biomarkers, in heart failure patients remain unknown. We initiated HIF-PH inhibitors in 13 patients with chronic heart failure and renal anemia (median age 77 years, median estimated glomerular filtration rate 24.9 mL/min/1.73m2 ) between September 2021 and February 2022. There were no drug-related complications, except for a patient who had a headache and hot flash, resulting in discontinuation of HIF-PH inhibitor at 3 months...
October 7, 2022: Heart and Vessels
https://read.qxmd.com/read/36195993/prevalence-risk-factors-and-survival-associated-with-pulmonary-hypertension-and-heart-failure-among-patients-with-underlying-coronary-artery-disease-a-national-prospective-multicenter-registry-study-in-china
#20
MULTICENTER STUDY
Li Huang, Lingpin Pang, Qing Gu, Tao Yang, Wen Li, Ruilin Quan, Weiqing Su, Weifeng Wu, Fangming Tang, Xiulong Zhu, Jieyan Shen, Jingzhi Sun, Guangliang Shan, Changming Xiong, Shian Huang, Jianguo He
BACKGROUND: Coronary artery disease (CAD) is the commonest cause of heart failure (HF), whereas pulmonary hypertension (PH) has not been established or reported in this patient population. Therefore, we assessed the prevalence, risk factors, and survival in CAD-associated HF (CAD-HF) complicated with PH. METHODS: Symptomatic CAD-HF patients were continuously enrolled in this prospective, multicenter registry study. Echocardiography, coronary arteriography, left and right heart catheterization (RHC), and other baseline clinical data were recorded...
August 5, 2022: Chinese Medical Journal
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