Markus Wennmann, Peter Neher, Nikolas Stanczyk, Kim-Celine Kahl, Jessica Kächele, Vivienn Weru, Thomas Hielscher, Martin Grözinger, Jiri Chmelik, Kevin Sun Zhang, Fabian Bauer, Tobias Nonnenmacher, Manuel Debic, Sandra Sauer, Lukas Thomas Rotkopf, Anna Jauch, Kai Schlamp, Elias Karl Mai, Niels Weinhold, Saif Afat, Marius Horger, Hartmut Goldschmidt, Heinz-Peter Schlemmer, Tim Frederik Weber, Stefan Delorme, Felix Tobias Kurz, Klaus Maier-Hein
OBJECTIVES: Diffusion-weighted magnetic resonance imaging (MRI) is increasingly important in patients with multiple myeloma (MM). The objective of this study was to train and test an algorithm for automatic pelvic bone marrow analysis from whole-body apparent diffusion coefficient (ADC) maps in patients with MM, which automatically segments pelvic bones and subsequently extracts objective, representative ADC measurements from each bone. MATERIALS AND METHODS: In this retrospective multicentric study, 180 MRIs from 54 patients were annotated (semi)manually and used to train an nnU-Net for automatic, individual segmentation of the right hip bone, the left hip bone, and the sacral bone...
October 3, 2022: Investigative Radiology