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Molluscum contagiosum

José Manuel Fernández Armenteros, Nuria Arco Huguet, Veronica Sanmartin Novell, Felip Vilardell Villellas, Ana Velasco Sanchez, Elisa Martró Català, Rosa Maria Martí Laborda, Xavier Soria Gili
Langerhans cell histiocytosis (LCH) is a disorder characterized by accumulation of Langerhans-like cells in one or various organs. A correct staging work-up is essential since there are multiorgan presentations with a poor prognosis. We report three patients with LCH skin lesions mimicking molluscum contagiosum in association with both high and low risk organ involvement. This peculiar cutaneous presentation can be a clue for the diagnosis of LCH, a disease with potentially severe systemic involvement.
March 12, 2018: Pediatric Blood & Cancer
Concepció Teixidó, Olga Díez, Josep R Marsal, Maria Giner-Soriano, Helena Pera, Mireia Martinez, Gisela Galindo-Ortego, Joan A Schoenenberger, Jordi Real, Ines Cruz, Rosa Morros
BACKGROUND/OBJECTIVES: Molluscum contagiosum is the most common skin infection in children. One topical treatment used for Molluscum contagiosum is potassium hydroxide. The objective of this study was to compare the efficacy of potassium hydroxide topical treatment at different concentrations with that of placebo in terms of complete clearing of Molluscum contagiosum lesions and to assess the safety and tolerance of potassium hydroxide topical treatment. METHODS: This was a double-blind randomized clinical trial of three treatments (potassium hydroxide 10%, potassium hydroxide 15%, placebo) applied once daily up to complete clearing of lesions (maximum duration 60 days) in 53 children aged 2-6 years in primary health care pediatric offices in Catalonia, Spain...
February 26, 2018: Pediatric Dermatology
Iria Neri, Giulia Liberati, Annalucia Virdi, Annalisa Patrizi
No abstract text is available yet for this article.
August 2017: Paediatrics & Child Health
Shan Wang, Wenjun Mou, Zhe Xu, Jingang Gui, Lin Ma
The hyper-IgE syndromes (HIES) are complex primary immunodeficiency disorders, including autosomal dominant form (AD-HIES) and recessive form (AR-HIES). Here we describe two boys with AR-HIES in a Chinese family and a novel mutation of DOCK8 gene was identified.The index patient was an 8-year-old boy. He presented with recurrent flexural skin lesions (similar with atopic dermatitis (AD)) for more than 5 years (Fig. 1a,b), and a 6-months history of severe molluscum contagiosum(Fig. 1c) and verruca plana(Fig...
February 8, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Marie Kenney, Elizabeth B Lester, Deborah L Cook
Inverted follicular keratosis is a benign follicular tumor. Tumors classically demonstrate lobulated, endophytic growth with squamous eddy formation. The histologic differential diagnosis includes irritated seborrheic keratosis, trichilemmoma, verruca vulgaris, squamous cell carcinoma, and keratoacanthoma. The clinical differential diagnosis includes verruca, molluscum contagiosum, follicular cyst, and squamous cell carcinoma. In the past, a predilection for the head and neck of elderly men has been reported...
February 8, 2018: Journal of Cutaneous Pathology
Sunetra Biswas, Geoffrey L Smith, Edward J Roy, Brian Ward, Joanna L Shisler
Molluscum contagiosum virus (MCV) causes persistent, benign skin neoplasm in children and adults. MCV is refractive to growth in standard tissue culture and there is no relevant animal model of infection. Here we investigated whether another poxvirus (vaccinia virus; VACV) could be used to examine MCV immunoevasion protein properties in vivo. The MCV MC159L or MC160L genes, which encode NF-κB antagonists, were inserted into an attenuated VACV lacking an NF-κB antagonist (vΔA49), creating vMC159 and vMC160...
February 2018: Journal of General Virology
Elena Chiappini, Mauro Zaffaroni, Martina Bianconi, Giuseppina Veneruso, Nicolino Grasso, Silvia Garazzino, Rosangela Arancio, Piero Valentini, Anna Ficcadenti, Maria Rosalia Da Riol, Simona La Placa, Luisa Galli, Maurizio de Martino, Gianni Bona
AIM: This study evaluated the prevalence of infectious diseases and immunisation status of children adopted from Africa METHODS: We studied 762 African children referred to 11 Italian paediatric centres in 2009-2015. Clinical and laboratory data were retrospectively collected and analysed. RESULTS: The median age of the children (60.3% males) was 3.6 years, 52.6% came from Ethiopia and 50.1% had at least one infectious disease. Parasitic infections accounted for the majority of the infectious diseases (409/715) and the most common were Giardia lamblia (n=239), Toxocara canis (n=65) and skin infections (n=205), notably Tinea capitis/corporis (n=134) and Molluscum contagiosum (n=56) Active tuberculosis (TB) was diagnosed in nine children (1...
January 24, 2018: Acta Paediatrica
Ronald L Moy, Corey Levenson
Many skin conditions and diseases are characterized by inflammation, infection, and hyperplasia. Safe and effective topical treatment options that can be used long-term are needed. Traditional botanical medicines, which are often complex mixtures that exert their biological activities via multiple mechanisms of action, are being studied as potential new active ingredients in dermatology. Sandalwood album oil (SAO), also known as East Indian sandalwood oil (EISO), is an essential oil distilled from the Santalum album tree and has demonstrated biological activity as an anti-inflammatory, anti-microbial, and anti-proliferative agent...
October 2017: Journal of Clinical and Aesthetic Dermatology
Kristen N Ruby, Ann E Perry, Konstantinos Linos
No abstract text is available yet for this article.
January 11, 2018: American Journal of Dermatopathology
Iria Neri, Camilla Loi, Michela Magnano, Paola Sgubbi, Annalisa Patrizi
No abstract text is available yet for this article.
February 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Johannes C van der Wouden, Sander Koning, Kenneth A Katz
Clinical Question: How effective and safe are treatments for nongenital molluscum contagiosum in persons without immune deficiency? Bottom Line: Compared with placebo, imiquimod, 5%, cream was not more effective in clearing molluscum contagiosum and caused more local adverse effects, including application site reactions, in children aged 2 to 12 years; because high-quality evidence for other interventions is lacking, allowing for natural resolution of the infection remains a reasonable approach...
December 27, 2017: JAMA Dermatology
Marla N Jahnke, Sook Hwang, James L Griffith, Tor Shwayder
No abstract text is available yet for this article.
January 2018: Journal of the American Academy of Dermatology
Dhrubajyoti Sharma, Ankur K Jindal, Amit Rawat, Surjit Singh
Primary immunodeficiency disorders (PIDs) are a group of disorders affecting the capability to fight against infection. These include defects in T cells and B cells affecting cell-mediated and humoral immunity, respectively, combined humoral and cell-mediated immunodeficiency, defects in phagocytosis, complement defects, and defects in cytokine or cytokine signalling pathways which are detrimental for immune function. Depending upon the type and severity, age at onset of symptoms can vary from neonatal period to late childhood...
November 2017: Indian Dermatology Online Journal
Katerina Damevska, Arben Emurlai
A 7-year-old boy presented to the dermatology clinic with a 3-month history of widespread, mildly pruritic skin lesions. He had a history of atopic dermatitis that had been treated with topical glucocorticoids for several months. The skin examination revealed numerous flesh-colored papules..
November 23, 2017: New England Journal of Medicine
Joaquín López-Robles, Lucía Núñez, Elena Macias-Del-Toro, José Luis Ramírez-Bellver, José Luis Díaz, Luis Requena
Juvenile xanthogranuloma is the most common form of non-Langerhans cell histiocytosis in childhood. The clinical differential diagnosis of a solitary juvenile xanthogranuloma includes molluscum contagiosum, Spitz nevus, and melanoma. Lesions larger than 2 cm in diameter may be misdiagnosed as hemangiomas, but this is not typical of smaller juvenile xanthogranuloma. We report a case of solitary juvenile xanthogranuloma in a 10-year-old boy with angiomatous appearance and peculiar immunophenotype.
November 22, 2017: Pediatric Dermatology
Ashli Lawson, Adnan Mir, Ellen E Wilson
BACKGROUND: Mastocytosis is a rare benign disorder characterized by the finding of mast cells in the skin and other organs, occurring in both adult and pediatric age groups. The cutaneous form is the most common presentation in childhood and is rarely located on the vulva. CASE: A 9 year old prepubertal girl presented with bilateral vulvar nodules found incidentally by her pediatrician. Biopsy and histopathologic review confirmed mastocytosis. Her lesions significantly diminished over the following year...
November 18, 2017: Journal of Pediatric and Adolescent Gynecology
M B Notenboom-Kool, W Opstelten
A healthy 1-year old girl visits her general practitioner with a solitary dome-shaped tumour on her thorax. The lesion is about one cm in diameter and is present since several months. Pathological research reveals a solitary giant molluscum contagiosum. This is a common viral disease of the childhood. In contrast to this case, mollusca contagiosa typically present as several small papules.
2017: Nederlands Tijdschrift Voor Geneeskunde
Subuhi Sherwani, Mohammed Chowdhury, Joachim J Bugert
Molluscum contagiosum virus (MCV) is a common skin pathogen of children and young adults. Infection with MCV causes benign skin tumors in children and young adults and is mostly self-limiting. In contrast to orthopoxviruses, MCV infections tend to take a subacute clinical course but may persist for up to 12 months. Current numbers for MCV seroprevalence in different geographical areas are based on a variety of historical serological methods from complement fixation assays to MCV ELISAs based on purified MCV virions and MC133 antigen expressed in a Semliki Forest Virus expression system...
November 9, 2017: Current Protocols in Microbiology
Malika Haque, Daniel L Coury
OBJECTIVES: To evaluate the safety and efficacy of an East Indian sandalwood oil (EISO) product as a topical treatment for molluscum contagiosum. MATERIALS AND METHODS: Ten subjects ranging in age from 22 months to 29 years were recruited. Subjects were instructed to apply an EISO product to the lesions twice daily. Subjects were monitored every two to three weeks during the study and were questioned regarding local or systemic side effects. Assessment of response was recorded by counting lesions and documented by photographs...
November 22, 2017: Journal of Dermatological Treatment
Gino Antonio Vena, Nicoletta Cassano
No abstract text is available yet for this article.
November 2017: International Journal of STD & AIDS
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