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Molluscum contagiosum

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https://www.readbyqxmd.com/read/28555548/recombination-events-and-variability-among-full-length-genomes-of-co-circulating-molluscum-contagiosum-virus-subtypes-1-and-2
#1
Alberto López-Bueno, Marcos Parras-Moltó, Olivia López-Barrantes, Sylvia Belda, Alí Alejo
Molluscum contagiosum virus (MCV) is the sole member of the Molluscipoxvirus genus and causes a highly prevalent human disease of the skin characterized by the formation of a variable number of lesions that can persist for prolonged periods of time. Two major genotypes, subtype 1 and subtype 2, are recognized, although currently only a single complete genomic sequence corresponding to MCV subtype 1 is available. Using next-generation sequencing techniques, we report the complete genomic sequence of four new MCV isolates, including the first one derived from a subtype 2...
May 30, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28543922/molluscum-contagiosum-of-the-gluteal-cleft-observations-and-implications-for-management-in-five-children
#2
Joshua R Bakke, Sarah L Stein
Molluscum contagiosum (MC) is a common, self-limited skin infection caused by a double-stranded DNA virus of the family Poxviridae. Although the morphology of the disease is well described, MC presenting at unusual sites can exhibit atypical morphology, resulting in misdiagnosis. This observational, retrospective case series discusses the novel morphology of MC presenting in the intergluteal cleft of five children seen in the outpatient dermatology clinic of an academic medical center. We present this case series to highlight this novel presentation of MC in children and to emphasize a conservative approach to management given the sensitive location and the self-limited nature of the infection...
May 25, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28528469/multiple-sclerosis-treatment-with-fingolimod-profile-of-non-cardiologic-adverse-events
#3
REVIEW
Yara Dadalti Fragoso
Fingolimod was the first oral medication approved for management of multiple sclerosis and is currently used by tens of thousands patients worldwide. Fingolimod acts via the sphingosine 1-phosphate (S1P) receptor, maintaining peripheral lymphocytes entrapped in the lymph nodes. In consequence, there is a reduction in the infiltration of aggressive lymphocytes into the central nervous system. The drug is safe and effective, and its first hours of use are associated with related to S1P receptors in the heart...
May 20, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28521677/molluscum-contagiosum-an-update
#4
Alexander Kc Leung, Benjamin Barankin, Kam Lun Hon
BACKGROUND: Molluscum contagiosum is a viral cutaneous infection in childhood that occurs worldwide. Physicians should familiarize themselves with this common condition. OBJECTIVE: To review in depth the epidemiology, pathophysiology, clinical manifestations, complications and, in particular, treatment of molluscum contagiosum. METHODS: A PubMed search was completed in Clinical Queries using the key term "molluscum contagiosum". Patents were searched using the key term "molluscum contagiosum" from www...
May 17, 2017: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/28515292/molluscum-contagiosum-virus-mc159-abrogates-ciap1-nemo-interactions-and-inhibits-nemo-polyubiquitination
#5
Sunetra Biswas, Joanna L Shisler
Molluscum contagiosum virus (MCV) is a dermatotropic poxvirus that causes benign skin lesions. MCV lesions persist because of virally-encoded immune evasion molecules that inhibit anti-viral responses. The MCV MC159 protein suppresses NF-κB activation, a powerful anti-viral response, via interactions with the NEMO subunit of the IKK complex. Binding of MC159 to NEMO does not disrupt the IKK complex, implying that MC159 prevents IKK activation via an as-yet-identified strategy. Here, we demonstrated that MC159 inhibited NEMO polyubiquitination, a post-translational modification required for IKK and downstream NF-κB activation...
May 17, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28513067/interventions-for-cutaneous-molluscum-contagiosum
#6
REVIEW
Johannes C van der Wouden, Renske van der Sande, Emma J Kruithof, Annet Sollie, Lisette Wa van Suijlekom-Smit, Sander Koning
BACKGROUND: Molluscum contagiosum is a common skin infection that is caused by a pox virus and occurs mainly in children. The infection usually resolves within months in people without immune deficiency, but treatment may be preferred for social and cosmetic reasons or to avoid spreading the infection. A clear evidence base supporting the various treatments is lacking.This is an update of a Cochrane Review first published in 2006, and updated previously in 2009. OBJECTIVES: To assess the effects of specific treatments and management strategies, including waiting for natural resolution, for cutaneous, non-genital molluscum contagiosum in people without immune deficiency...
May 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28490597/molluscum-contagiosum-virus-protein-mc005-inhibits-nf%C3%AE%C2%BAb-activation-by-targeting-nemo-regulated-ikk-activation
#7
Gareth Brady, Darya A Haas, Paul J Farrell, Andreas Pichlmair, Andrew G Bowie
Molluscum Contagiosum Virus (MCV), the only known extant, human-adapted poxvirus, causes a long-duration infection characterized by skin lesions that typically display an absence of inflammation despite containing high titres of live virus. Despite this curious presentation, MCV is very poorly characterized in terms of host-pathogen interactions. The absence of inflammation around MCV lesions suggests the presence of potent inhibitors of human anti-viral immunity and inflammation. However, only a small number of MCV immunomodulatory genes have been characterized in detail...
May 10, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28462780/-african-histoplamosis-a-report-of-three-pediatric-cases
#8
REVIEW
J R Mabiala Babela, C Mboutol Mandavo, R Nika Evrard, B Ossibi Ibara, L Lamah, L C Ollandzobo Ikobo, A Mouko, J F Peko
Histoplasmosis duboisii (Histoplasma capsulatum var duboisii) is uncommon disease especially in children. It is observed in Africa where the incidence is unknown. The authors report a series of three pediatric cases. The report concerned 2 girls and one boy who were 3, 9 and 4 year-old, respectively. Symptoms evolved for more than two months in each case. At admission, we found fever and poor general condition. Observed lesions were lymphnodes localisation disseminated (cases 1 and 2), subcutaneous (cold abscess) and cutaneous simulating molluscum contagiosum (case 2), osteoarticular (cases 2 and 3), abdominal including peritoneal and hepatosplenic (case 1)...
April 24, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28442804/clinico-epidemiological-profile-of-patients-attending-suraksha-clinic-of-tertiary-care-hospital-of-north-india
#9
H S Banger, Anisha Sethi, Sita Malhotra, Suresh Kumar Malhotra, Tejinder Kaur
BACKGROUND: Sexually transmitted infections (STIs) are a global health problem. Trends of STIs vary from place to place depending on various epidemiological factors prevailing in that respective geographic area. AIMS AND OBJECTIVES: The present study was conducted to find the pattern and prevalence of different STIs out of total STI clinic attendees, to identify any change in the trend of STIs, various epidemiological factors, and behavior of individual diseases...
January 2017: Indian Journal of Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28425034/the-molluscum-contagiosum-virus-death-effector-domain-containing-protein-mc160-rxdl-motifs-are-not-required-for-its-known-viral-immune-evasion-functions
#10
Michael Beaury, Uday Kiran Velagapudi, Sarah Weber, Cassandra Soto, Tanaji T Talele, Daniel Brian Nichols
The molluscum contagiosum virus (MCV) uses a variety of immune evasion strategies to antagonize host immune responses. Two MCV proteins, MC159 and MC160, contain tandem death effector domains (DEDs). They are reported to inhibit innate immune signaling events such as NF-κB and IRF3 activation, and apoptosis. The RxDL motif of MC159 is required for inhibition of both apoptosis and NF-κB activation. However, the role of the conserved RxDL motif in the MC160 DEDs remained unknown. To answer this question, we performed alanine mutations to neutralize the arginine and aspartate residues present in the MC160 RxDL in both DED1 and DED2...
April 20, 2017: Virus Genes
https://www.readbyqxmd.com/read/28406414/review-of-poxvirus-emergence-of-monkeypox
#11
A Morand, S Delaigue, J J Morand
This article reviews the different types of poxvirus infections. Smallpox, although eradicated, must continue to be monitored because of the potential risk of accidental or voluntary (by bioterrorism) reintroduction. Monkeypox and cowpox viruses are considered to be emergent today ; their high risk of dissemination is due to the increase in international transport as well as trends for new animals as pets and the loss of vaccinal protection against smallpox. Molluscum contagiosum (molluscipoxvirus) causes mild infections, is particularly frequent in children ; in adults it is a marker of the risk of sexually transmitted infections and can, in cases with profuse lesions, reveal AIDS...
February 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28397528/skin-diseases-of-the-vulva-infectious-diseases
#12
Freja Lærke Sand, Simon Francis Thomsen
A multitude of infectious diseases of viral (genital herpes, herpes zoster, genital warts and molluscum contagiosum), bacterial (syphilis, chancroid, lymphogranuloma venereum, donovanosis, erysipelas, cellulitis and necrotising fasciitis, folliculitis, impetigo, bartholin gland abscess, trichomycosis and erythrasma), fungal (candidiasis and dermatophytosis) and parasitic (pediculosis pubis) origin may affect the vulvar area. Herein, we review the infections and their skin manifestations in the vulvar area.
April 11, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28360968/molluscum-contagiosum-treated-with-dilute-povidone-iodine-a-series-of-cases
#13
Kara Capriotti, Kevin Stewart, Jesse Pelletier, Joseph Capriotti
Objective: To report our experience using a broad spectrum antimicrobial, povidone-iodine, as a novel at-home prescription treatment for molluscum contagiosum. Design/Setting: A systematic review of cases presenting to one of the author's private dermatology clinics from January to July of 2015 identified 12 patients with molluscum contagiosum seeking treatment. Participants: The population was pediatric, with six males and six female patients included (age range 2-17 years, mean age 6 years). Measurements: Patients were evaluated at baseline and returned to the office for evaluation at four-week intervals until resolution or failure to show for appointments, with number and location of lesions being recorded at each visit...
March 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28329651/infections-in-children-with-eczema-in-uk-general-practice-a-cohort-study
#14
Sinéad M Langan, Katrina Abuabara, Sarah E Henrickson, Ole Hoffstad, David J Margolis
BackgroundCase reports and cross-sectional studies suggest increased risks of cutaneous and non-cutaneous infections in eczema; this relationship needs to be assessed in large population-based studies with diagnostic confirmation. The objective was to examine associations between eczema and common childhood infections.MethodsIndividuals registered prior to age 18 in the Health Improvement Network, a UK general practice database, from 2003 to 2013 were included in this cohort study. We determined the association between eczema and selected infectious outcomes, including cutaneous (dermatophyte, herpes simplex virus, impetigo, molluscum contagiosum and warts), and non-cutaneous infections (otitis media, streptococcal throat infections, and pneumonia)...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28328809/infectious-diseases-prevalence-vaccination-coverage-and-diagnostic-challenges-in-a-population-of-internationally-adopted-children-referred-to-a-tertiary-care-children-s-hospital-from-2009-to-2015
#15
Sara Sollai, Francesca Ghetti, Leila Bianchi, Maurizio de Martino, Luisa Galli, Elena Chiappini
Infectious diseases are common in internationally adopted children (IAC).With the objective to evaluate infectious diseases prevalence in a large cohort of IAC and to explore possible risk factors for tuberculosis (TB) and parasitic infections, clinical and laboratory data at first screening visit of all IAC (<18 years) consecutively referred to our Center in 2009 to 2015 were collected and analyzed.In total, 1612 children (median age: 5.40 years; interquartile range: 3.00-7.90) were enrolled, 123/1612 (7...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28322681/disseminated-molluscum-contagiosum-lesions-in-an-hiv-patient
#16
Telma Azevedo, Alexandre Catarino, Lurdes Ferreira, Fernando Borges, Kamal Mansinho
No abstract text is available yet for this article.
March 2017: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/28300437/botanicals-with-dermatologic-properties-derived-from-first-nations-healing
#17
Sophia Colantonio, Jason K Rivers
INTRODUCTION: Plants and algae have played a central role in the treatment of skin conditions in both traditional First Nations healing and in modern dermatology. The objective of this study was to examine the evidence supporting the dermatological use of seaweed, witch hazel, bearberry, and mayapple. METHODS: Four plants and algae used in traditional First Nations treatments of skin disease were selected based on expert recommendations. Several databases were searched to identify relevant citations without language restrictions...
December 1, 2016: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28273975/molluscum-contagiosum-of-cervix-a-case-report
#18
Ankita Bagel, Kalyani Raju, Munikrishna Munisamaiah, Bachu Narayanaswamy Raghavendra Prasad
Molluscum Contagiosum (MC) is a common viral infection of skin caused by a double stranded DNA Pox virus affecting both adults and children. MC is primarily an infection of school-going children (one to five years), occasionally it affects adults and immunocompromised individuals. Transmission of virus occurs by direct contact with infected persons or contaminated objects. Most common sites are skin of face, trunk and extremities in children, genitals in adults and rarely palms, soles and mucous membranes. The occurrence of MC in genitals is lowest (3%)...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28243996/multiple-molluscum-contagiosum-lesions-in-adults-suggesting-compromised-immune-system
#19
Takuya Miyagawa, Takafumi Kadono, Miki Miyazaki, Shinichi Sato
No abstract text is available yet for this article.
February 27, 2017: Infection
https://www.readbyqxmd.com/read/28235685/the-molluscum-contagiosum-virus-protein-mc163-localizes-to-the-mitochondria-and-dampens-mitochondrial-mediated-apoptotic-responses
#20
Jesse Coutu, Melissa R Ryerson, Joachim Bugert, Daniel Brian Nichols
Apoptosis is a powerful host cell defense to prevent viruses from completing replication. Poxviruses have evolved complex means to dampen cellular apoptotic responses. The poxvirus, Molluscum Contagiosum Virus (MCV), encodes numerous host interacting molecules predicted to antagonize immune responses. However, the function of the majority of these MCV products has not been characterized. Here, we show that the MCV MC163 protein localized to the mitochondria via an N-terminal mitochondrial localization sequence and transmembrane domain...
May 2017: Virology
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