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JOURNAL ARTICLE
William B Grant, Edward B Jude
The communication by Thiele et al. reported that there were no significant differences in serum 25-hydroxyvitamin D (25(OH)D) for the 22 of 118 acute heart failure (HF) patients, 71% with de novo HF and 29% with chronic HF, who died within 12 months after admission to the intermediate care unit of a maximum care hospital in Germany compared to those who survived [...].
October 13, 2022: Journal of Clinical Medicine
#22
JOURNAL ARTICLE
S Zhang, X Zhang, S Wu, T Zhang, H M Ji, Q Zhang, J Gao, C Pan, J J Pang, F Xu, J L Wang, Yuguo Chen
Objective: To compare the clinical features and the outcome of in-hospital mortality between patients with myocardial infarction with non-obstructive coronary arteries(MINOCA)and myocardial infarction with obstructive coronary artery disease (MI-CAD). Methods: This is a retrospective study. The clinical data of acute myocardial infarction (AMI) patients admitted to Qilu Hospital of Shandong University from January 2017 to May 2021, who underwent coronary angiography, were collected. Patients were divided into MINOCA group and MI-CAD group according to the degree of coronary stenosis (<50% or ≥50%)...
September 24, 2022: Zhonghua Xin Xue Guan Bing za Zhi
#23
JOURNAL ARTICLE
Harrison G Zhang, Arianna Dagliati, Zahra Shakeri Hossein Abad, Xin Xiong, Clara-Lea Bonzel, Zongqi Xia, Bryce W Q Tan, Paul Avillach, Gabriel A Brat, Chuan Hong, Michele Morris, Shyam Visweswaran, Lav P Patel, Alba Gutiérrez-Sacristán, David A Hanauer, John H Holmes, Malarkodi Jebathilagam Samayamuthu, Florence T Bourgeois, Sehi L'Yi, Sarah E Maidlow, Bertrand Moal, Shawn N Murphy, Zachary H Strasser, Antoine Neuraz, Kee Yuan Ngiam, Ne Hooi Will Loh, Gilbert S Omenn, Andrea Prunotto, Lauren A Dalvin, Jeffrey G Klann, Petra Schubert, Fernando J Sanz Vidorreta, Vincent Benoit, Guillaume Verdy, Ramakanth Kavuluru, Hossein Estiri, Yuan Luo, Alberto Malovini, Valentina Tibollo, Riccardo Bellazzi, Kelly Cho, Yuk-Lam Ho, Amelia L M Tan, Byorn W L Tan, Nils Gehlenborg, Sara Lozano-Zahonero, Vianney Jouhet, Luca Chiovato, Bruce J Aronow, Emma M S Toh, Wei Gen Scott Wong, Sara Pizzimenti, Kavishwar B Wagholikar, Mauro Bucalo, Tianxi Cai, Andrew M South, Isaac S Kohane, Griffin M Weber
The risk profiles of post-acute sequelae of COVID-19 (PASC) have not been well characterized in multi-national settings with appropriate controls. We leveraged electronic health record (EHR) data from 277 international hospitals representing 414,602 patients with COVID-19, 2.3 million control patients without COVID-19 in the inpatient and outpatient settings, and over 221 million diagnosis codes to systematically identify new-onset conditions enriched among patients with COVID-19 during the post-acute period...
June 29, 2022: NPJ Digital Medicine
#24
REVIEW
J David Spence, Graeme J Hankey
In this article, we discuss a problem in the most recent American Heart Association guideline on secondary stroke prevention that apparently arose from the rules of evidence imposed on the guideline panel. We are told by the cochair of the panel that American Heart Association rules about guidelines for secondary prevention prohibited consideration of primary prevention studies and secondary analyses of secondary prevention studies. However, evidence-based medicine should consider all the best external evidence available and also clinical judgement...
August 2022: Stroke; a Journal of Cerebral Circulation
#25
JOURNAL ARTICLE
Hina L Nizami, Parmeshwar B Katare, Pankaj Prabhakar, Ramu Adela, Soumalya Sarkar, Sudheer Arava, Praloy Chakraborty, Subir K Maulik, Sanjay K Banerjee
Objectives: Transition from cardiac hypertrophy to failure involves adverse metabolic reprogramming involving mitochondrial dysfunction. We have earlier shown that vitamin D deficiency induces heart failure, at least in part, through insulin resistance. However, whether activation of vitamin D receptor (VDR) can attenuate heart failure and underlying metabolic phenotype requires investigation. Thus, we aimed to assess the cardioprotective potential of paricalcitol, a vitamin D receptor-activator, against cardiac hypertrophy and failure in high-fat high-fructose-fed rats...
2022: Oxidative Medicine and Cellular Longevity
#26
RANDOMIZED CONTROLLED TRIAL
M Cecilia Bahit, Amit N Vora, Zhuokai Li, Daniel M Wojdyla, Laine Thomas, Shaun G Goodman, Ronald Aronson, J Dedrick Jordan, Brad J Kolls, Keith E Dombrowski, Dragos Vinereanu, Sigrun Halvorsen, Otavio Berwanger, Stephan Windecker, Roxana Mehran, Christopher B Granger, John H Alexander, Renato D Lopes
Importance: Data are limited regarding the risk of cerebrovascular ischemic events and major bleeding in patients with atrial fibrillation (AF) and recent acute coronary syndrome (ACS) and/or percutaneous coronary intervention (PCI). Objective: Determine the efficacy and safety of apixaban or vitamin K antagonists (VKA) and aspirin or placebo according to prior stroke, transient ischemic attack (TIA), or thromboembolism (TE). Design, Setting, and Participants: In this prospective, multicenter, 2-by-2 factorial, randomized clinical trial, post hoc parallel analyses were performed to compare randomized treatment regimens according to presence or absence of prior stroke/TIA/TE using Cox proportional hazards models...
July 1, 2022: JAMA Cardiology
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JOURNAL ARTICLE
Sri E Rahayuningsih, Rahmat B Kuswiyanto, Putria Rayani, Elrika A Wijaya, Mas R Syamsunarno, Raden T D Judistiani, Budi Setiabudiawan
INTRODUCTION: Ventricular septal defect is the most common CHD, leading to pulmonary hypertension. Significantly lower 25-hydroxyvitamin D level was reported in children with CHD compared with healthy controls. The current study aimed to investigate the correlation between 25-hydroxyvitamin D level and pulmonary hypertension in children with ventricular septal defect. METHODS: A cross-sectional study was conducted on ventricular septal defect paediatric patients from January to June, 2019...
December 2022: Cardiology in the Young
#28
REVIEW
Jérôme Piquereau, Solène E Boitard, Renée Ventura-Clapier, Mathias Mericskay
Heart failure (HF) is a plague of the aging population in industrialized countries that continues to cause many deaths despite intensive research into more effective treatments. Although the therapeutic arsenal to face heart failure has been expanding, the relatively short life expectancy of HF patients is pushing towards novel therapeutic strategies. Heart failure is associated with drastic metabolic disorders, including severe myocardial mitochondrial dysfunction and systemic nutrient deprivation secondary to severe cardiac dysfunction...
December 21, 2021: International Journal of Molecular Sciences
#29
JOURNAL ARTICLE
Derek S Chew, Zhen Li, Benjamin A Steinberg, Emily O'Brien, Jessica Pritchard, T Jared Bunch, Daniel B Mark, Manesh R Patel, Yelena Nabutovsky, Melissa A Greiner, Jonathan P Piccini
BACKGROUND: As the prevalence of atrial fibrillation (AF) increases, a greater understanding of the costs associated with AF care is required. While individuals with greater arrhythmic burden may interact with the health system more frequently, the relationship between AF burden and costs remains undefined. METHODS: In a longitudinal patient cohort with paroxysmal AF and newly implanted cardiovascular implantable electronic devices (CIED) (2010-2016), we linked CIED remote-monitoring data with Medicare claims to assess the association between the 30-day averaged device-detected daily percentage of time in AF ("AF burden") and healthcare costs...
February 2022: American Heart Journal
#30
REVIEW
John Eikelboom, Jürgen Floege, Ravi Thadhani, Jeffrey I Weitz, Wolfgang C Winkelmayer
Chronic kidney disease is present in almost 10% of the world population and is associated with excess mortality and morbidity. Reduced glomerular filtration rate and the presence and extent of proteinuria, key domains of chronic kidney disease, have both been shown to be strong and independent risk factors for cardiovascular disease. Patients with kidney failure requiring dialysis are at highest risk for cardiovascular events (e.g., stroke or myocardial infarction), and of developing chronic cardiovascular conditions, such as heart failure...
December 2021: Kidney International
#31
JOURNAL ARTICLE
Iskender Ekinci, Hafize Uzun, Irem Kirac Utku, Hanise Ozkan, Mitat Buyukkaba, Ahmet Cinar, Murat Akarsu, Abdulbaki Kumbasar, Omur Tabak
<b/> Purpose: This study aimed to investigate the effect of the nutritional status, as assessed by the prognostic nutritional index (PNI) on the disease prognosis of patients with COVID-19. Methods: This retrospective study included 282 patients with COVID-19. The PNI score of all patients, 147 of whom were male, with a mean age of 56.4±15.3 years, was calculated. According to the PNI score, the patients with normal and mild malnutrition constituted group-1 (n=159) and the patients with moderate-to-severe and serious malnutrition constituted group-2 (n=123)...
January 2022: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
#32
REVIEW
Hana M A Fakhoury, Peter R Kvietys, Ismail Shakir, Hashim Shams, William B Grant, Khaled Alkattan
SARS-CoV-2 infects the respiratory tract and leads to the disease entity, COVID-19. Accordingly, the lungs bear the greatest pathologic burden with the major cause of death being respiratory failure. However, organs remote from the initial site of infection (e.g., kidney, heart) are not spared, particularly in severe and fatal cases. Emerging evidence indicates that an excessive inflammatory response coupled with a diminished antiviral defense is pivotal in the initiation and development of COVID-19. A common finding in autopsy specimens is the presence of thrombi in the lungs as well as remote organs, indicative of immunothrombosis...
June 28, 2021: Nutrients
#33
Benzhen Wang, Zhanhui Du, Guangsong Shan, Chuanzhu Yan, Victor Wei Zhang, Zipu Li
Sengers syndrome (OMIM #212350) is a rare autosomal recessive disorder due to mutations in acylglycerol kinase ( AGK ) gene. We report two cases that were diagnosed clinically and confirmed genetically. Both infants had typical clinical features characterized by hypertrophic cardiomyopathy, bilateral cataracts, myopathy, and lactic acidosis, and heart failure was the most severe manifestation. Genetic testing of a boy revealed a homozygous pathogenic variant for Sengers syndrome in AGK (c.1131+2T>C) which was classified as likely pathogenic according to the ACMG guideline; besides, his skeletal muscle biopsy and transmission electron microscope presented obvious abnormity...
2021: Frontiers in Pediatrics
#34
JOURNAL ARTICLE
Ni Yang, Lauren Parker, Jianshi Yu, Jace W Jones, Ting Liu, Kyriakos N Papanicolaou, C Conover Talbot, Kenneth B Margulies, Brian O'Rourke, Maureen Kane, D Brian Foster
Though low circulating levels of the vitamin A metabolite, all-trans retinoic acid (ATRA), are associated with increased risk of cardiovascular events and all-cause mortality, few studies have addressed whether cardiac retinoid levels are altered in the failing heart. Here, we show that proteomic analyses of human and guinea pig heart failure (HF) are consistent a decline in resident cardiac ATRA. Quantitation of the retinoids in ventricular myocardium by mass spectrometry reveals 32 and 39% ATRA decreases in guinea pig HF and in patients with idiopathic dilated cardiomyopathy (IDCM), respectively, despite ample reserves of cardiac vitamin A...
March 16, 2021: JCI Insight
#35
JOURNAL ARTICLE
Jiunn-Miin Lin, Chih-Hsiang Hsu, Jeen-Chen Chen, Shao-Hsuan Kao, You-Cian Lin
Acute myocardial infarction (AMI) and the following heart failure are public health problems faced all over the globe. The current study set out to investigate the role of B-cell lymphoma 6 (BCL-6) in cardiac protection after AMI. Initially, AMI mouse models and H9c2 cell oxygen-glucose deprivation (OGD) models were established. The cell models were transfected with the vectors containing oe-BCL-6, oe-EZH2, sh-EZH2, miR-34a mimic, and miR-34a inhibitor. RT-qPCR and Western blot analysis were applied to detect the expression patterns of microRNA-34a (miR-34a), BCL-6, enhancer of zeste homolog 2 (EZH2), and C1q tumor necrosis factor-related protein 9 (CTRP9) in the treated cell models...
May 2021: BioFactors
#36
REVIEW
Marco B Morelli, Jessica Gambardella, Vanessa Castellanos, Valentina Trimarco, Gaetano Santulli
The potential beneficial effects of the antioxidant properties of vitamin C have been investigated in a number of pathological conditions. In this review, we assess both clinical and preclinical studies evaluating the role of vitamin C in cardiac and vascular disorders, including coronary heart disease, heart failure, hypertension, and cerebrovascular diseases. Pitfalls and controversies in investigations on vitamin C and cardiovascular disorders are also discussed.
December 3, 2020: Antioxidants (Basel, Switzerland)
#37
JOURNAL ARTICLE
Iwona Gorczyca, Olga Jelonek, Beata Uziębło-Życzkowska, Magdalena Chrapek, Małgorzata Maciorowska, Maciej Wójcik, Robert Błaszczyk, Agnieszka Kapłon-Cieślicka, Monika Gawałko, Monika Budnik, Tomasz Tokarek, Renata Rajtar-Salwa, Jacek Bil, Michał Wojewódzki, Anna Szpotowicz, Janusz Bednarski, Elwira Bakuła-Ostalska, Anna Tomaszuk-Kazberuk, Anna Szyszkowska, Marcin Wełnicki, Artur Mamcarz, Beata Wożakowska-Kapłon
BACKGROUND: Current guidelines do not suggest in which groups of patients with atrial fibrillation (AF) individual non-vitamin K antagonist oral anticoagulants (NOACs) should be used for the prevention of thromboembolic complications. The aim of this study was to evaluate the frequency of use of apixaban, dabigatran, and rivaroxaban, and attempt to identify factors predisposing their administration. METHODS: The Polish Atrial Fibrillation (POL-AF) registry is a prospective, non-interventional study, including consecutive patients with AF hospitalized in ten Polish cardiology centers during the period ranging from January to December 2019...
November 5, 2020: Journal of Clinical Medicine
#38
EDITORIAL
Vasiliki Bistola, Gerasimos Filippatos
No abstract text is available yet for this article.
November 6, 2020: Hellenic Journal of Cardiology: HJC
#39
RANDOMIZED CONTROLLED TRIAL
Sana M Al-Khatib, Sean D Pokorney, Hussein R Al-Khalidi, Kevin Haynes, Crystal Garcia, David Martin, Jennifer C Goldsack, Thomas Harkins, Noelle M Cocoros, Nancy D Lin, Hana Lipowicz, Debbe McCall, Vinit Nair, Lauren Parlett, Cheryl N McMahill-Walraven, Richard Platt, Christopher B Granger
BACKGROUND: Many studies showing underuse of oral anticoagulants (OACs) in patients with atrial fibrillation (AF) predated the advent of the non-vitamin K antagonist OACs. We retrospectively examined use of OACs in a large commercially insured population. METHODS: Administrative claims data from 4 research partners participating in FDA-Catalyst, a program of the Sentinel Initiative, were queried in September 2017. Patients were included if they were ≥30 years old with ≥365 days of medical/pharmacy coverage, and had ≥2 diagnosis codes for AF, a CHA2 DS2 -VASc score ≥2, absence of contraindications to OAC use, and no evidence of OAC use in the 365 days before the index AF diagnosis...
November 2020: American Heart Journal
#40
JOURNAL ARTICLE
Armin Zittermann, Jana B Ernst, Sylvana Prokop, Uwe Fuchs, Heiner K Berthold, Ioanna Gouni-Berthold, Jan F Gummert, Stefan Pilz
AIMS: Vitamin D supplementation is widely used in the clinical setting, but its effects on mortality and cardiovascular outcomes in patients with heart failure are unclear. This paper reports outcome data that were collected during follow-up of 3 years after closure of the EVITA trial (a 3 year randomized, placebo-controlled, intervention study with 4000 IU vitamin D daily in patients with advanced heart failure), to capture potential latency effects of vitamin D supplementation on clinical outcomes...
September 11, 2020: ESC Heart Failure
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