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Atypical marginal zone hyperplasia

Sultan Şevik Eliçora, Mehmet Güven, Ali F Varli, Mahmut S Yilmaz, Selin Alponat
Cases of posterior pharyngeal masses are quite rare, and are typically derived from schwannoma or encephalocele, or are of vascular or infectious origin. They are clinically significant due to their tendency to cause airway obstruction. The aim of this study was to present a rare atypical marginal hyperplasia case of a posterior pharyngeal wall mass. A 10-year-old male was admitted to our clinic with dyspnea. A plane-surfaced 4 × 3 × 3 cm mass was observed on the posterior pharyngeal wall upon physical examination...
March 2016: Journal of Pediatric Hematology/oncology
Leticia Quintanilla-Martinez, Birgitta Sander, John K C Chan, Luc Xerri, German Ott, Elias Campo, Steven H Swerdlow
Indolent lymphomas in the pediatric population were discussed during the 2014 European Association for Haematopathology/Society of Hematopathology workshop in Istanbul, Turkey. This session was focused on pediatric-type follicular lymphoma (FL), and its differential diagnosis with the newly recognized entity of IRF4/MUM1+ lymphomas mainly involving Waldeyer's ring. The differential diagnosis between t(14;18) negative FL grade 1/2 and pediatric-type FL in adults was highlighted. The overlapping pathological and clinical features between FL and nodal marginal zone lymphoma (NMZL) in children and young adults were recognized and morphologic and immunophenotypical criteria helpful for the differential diagnosis were presented...
February 2016: Virchows Archiv: An International Journal of Pathology
Shelley A Caltharp, Muna Qayed, Sunita I Park
Atypical marginal zone hyperplasia (AMZH) of mucosa-associated lymphoid tissue (MALT) closely resembles lymphoma in that it shows expansion of the marginal zones with prominent intraepithelial B lymphocytes, is immunoglobulin light-chain restricted, and may show aberrant CD43 expression. However, unlike lymphoma, it does not show rearrangement of the immunoglobulin heavy chain gene (immunoglobulin H [IgH]) by polymerase chain reaction (PCR), and it behaves in a benign fashion. We identified AMZH in 2 pediatric solid organ transplant recipients who presented with adenotonsillar hypertrophy...
September 2015: Pediatric and Developmental Pathology
Michael Sedrak, Akila Muthukumar, M Tarek Elghetany, You-Wen Qian
Atypical marginal zone hyperplasia (AMZH) is a recently described disease entity seen mainly in children. AMZH most commonly affects tonsils and appendices. Cutaneous AMZH is rare. The authors report here a recurrent AMZH in the lip of a 9-year-old child who presented originally with a lip swelling for approximately 3 months. The lip lesion recurred after each incomplete excision for 4 times. Pathologically, the lesion demonstrated marginal zone B-cell hyperplasia with kappa monoclonality by flow cytometry and immunohistochemistry studies...
April 2015: American Journal of Dermatopathology
Yuko Kaneko, Masaru Kojima, Seiichiro Suzuki, Atsuko Takada, Hidetsugu Yamagishi, Yoshimasa Nakazato, Nobuhide Masawa
This study attempted to clarify the clinicopathological and immunohistochemical findings and presence or absence of Epstein-Barr virus (EBV) in tonsillar atypical interfollicular hyperplasia (AIFH). A total of 597 consecutive specimens from tonsillectomies performed in Dokkyo University School of Medicine between 1999 and July 2013 were reexamined. Using formalin-fixed, paraffin-embedded sections, histological and immunohistochemical analyses, and in situ hybridization (ISH) were performed. AIFH was identified in the tonsils in 12 (2...
2014: Journal of Clinical and Experimental Hematopathology: JCEH
Hind M Alkatan, Ahmad Alaraj, Albarah El-Khani, Osama Al-Sheikh
PURPOSE: To study the pattern of ocular adnexal lymphoproliferative disorders (OALD) in an ophthalmic referral center in Saudi Arabia and to review their, histopathological characteristics with clinical correlation. METHODS: Retrospective chart review of 40 cases of patients who underwent incisional biopsy with the suspected diagnosis of periocular and/or adnexal lymphoid lesions over the period: 2000-2012 at the King Khaled Eye Specialist Hospital (KKESH), Riyadh, Saudi Arabia...
July 2013: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
J Zhu, R L Wei, Y L Pi, Q Guo
We investigated the expression of Bcl10 gene mutations in mucosa-associated lymphoid tissue-type ocular adnexal lymphoma (OAL), atypical lymphoid hyperplasia (ALH), and reactive lymphoid hyperplasia (RLH) in the Chinese population and its role in clinical diagnosis and pathogenesis. Forty-three samples were collected during patient surgeries. Pathological diagnosis confirmed OAL in 23 cases, ALH in 10 cases, and RLH in 10 cases. Normal peripheral lymph tissues from 12 cases were used as negative controls. Bcl10 gene expression was examined using molecular biological methods, and DNA sequences and mutations were compared with published data...
2013: Genetics and Molecular Research: GMR
Alejandra Carvajal-Cuenca, Elías Campo
The differential diagnosis between neoplastic and reactive lymphoid proliferations is a relatively common situation, which in most cases is resolved using conventional morphological and phenotypic criteria. In the last years, a number of studies have identified different types of lymphoid lesions sharing pathological and molecular features of both benign and malignant processes that are difficult to interpret. A group of these lesions correspond to atypical lymphoid hyperplasias, including follicular hyperplasias, atypical marginal zone hyperplasias, and florid reactive lymphoid hyperplasias of the lower female genital tract in which immunoglobulin light chain restriction with or without clonal IGH rearrangements may be found in some cases...
May 2013: Seminars in Diagnostic Pathology
Teresa Marafioti, Christiane Copie-Bergman, Maria Calaminici, Jennifer C Paterson, Vishvesh H Shende, Hongxiang Liu, Maryse Baia, Alan D Ramsay, Claudio Agostinelli, Josette Brière, Andrew Clear, Ming-Qing Du, Pier Paolo Piccaluga, Noraidah Masir, Elizabeth P Nacheva, Pierre Sujobert, Kandavel Shanmugam, Thomas M Grogan, Simon P Brooks, Asim Khwaja, Kirit Ardeshna, William Townsend, Stefano A Pileri, Corinne Haioun, David Linch, John G Gribben, Philippe Gaulard, Peter G Isaacson
AIMS: The aim of this study was to analyse the immunophenotypic and molecular features of a large series of follicular lymphomas, focusing in particular on atypical cases that fail to express CD10 and/or bcl-2. Such cases present diagnostic pitfalls, especially with regard to the differential diagnosis from follicular hyperplasia and marginal zone B-cell lymphoma. Therefore, we also included an immunohistochemical evaluation of stathmin, which is strongly expressed by germinal centre B cells, as a putative new marker for follicular lymphomas, particularly those with an atypical phenotype...
May 2013: Histopathology
Judith A Ferry, Vikram Deshpande
Lymphoid infiltrates are relatively common in the ocular adnexa and the salivary glands. They are of a variety of types and include both reactive processes and lymphomas. Within the ocular adnexa in years past, lymphoid proliferations were classified as inflammatory pseudotumor, reactive lymphoid hyperplasia, atypical lymphoid hyperplasia, and lymphoma. With improvements in diagnostic techniques and with advances in lymphoma subclassification, it became clear that many of the dense lymphoid infiltrates, including cases classified as lymphoma and likely some classified as atypical lymphoid hyperplasia, represented low-grade B-cell lymphomas, the most common of which by far were extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT) lymphomas...
November 2012: Seminars in Diagnostic Pathology
Junichi Fukuhara, Satoru Kase, Mika Noda, Kan Ishijima, Teppei Yamamoto, Susumu Ishida
Extra nodal marginal zone B-cell lymphoma (EMZL) of the conjunctiva typically arises in the marginal zone of mucosa-associated lymphoid tissue. The pathogenesis of conjunctival EMZL remains unknown. We describe an unusual case of EMZL arising from reactive lymphoid hyperplasia (RLH) of the conjunctiva. A 35-year-old woman had fleshy salmon-pink conjunctival tumors in both eyes, oculus uterque (OU). Specimens from conjunctival tumors in the right eye, oculus dexter (OD), revealed a collection of small lymphoid cells in the stroma...
2012: World Journal of Surgical Oncology
Prabhjot Kaur, Norman B Levy
No abstract text is available yet for this article.
April 2012: American Journal of Hematology
Wu Song, Yu-long He, Fang-hai Han, Shi-rong Cai, Jian-jun Peng
OBJECTIVE: To report a case of rectal non-Hodgkin lymphoma with concomitant rectal adenocarcinoma. METHODS: Clinical records of a 71 years old male patient with rectal non-Hodgkin lymphoma with concomitant rectal adenocarcinoma admitted on May 19, 2010 to the First Affiliated Hospital of Sun Yet-sen University were retrospectively reviewed. Clinical manifestations, diagnosis, and treatment as well as postoperative pathology were summarized. RESULTS: The preoperative diagnosis of the patient was severe atypical adenomatous hyperplasia with focal carcinogenesis, and the preoperative staging was T2N0-1M0...
August 2011: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Zhi-Gang Li, Xiao Wang, Xiang-Yong Pan, Min Li, Shi-Qi Zou
OBJECTIVE: To investigate the clinicopathologic features of reactive hyperplasia of lymph nodes in maxillofacial regions. METHODS: Thirty-two patients with lymph node reactive hyperplasia (LRH) were analyzed clinicopathologically including pathomorphologic manifestation and immunohistochemical expression. RESULTS: Histopathology of 32 patients showed significant hyperplasia in folliculus lymphaticus, marginal zone lymph, paracortical area lymph, and seldom mixed hyperplasia...
April 2011: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
Takaaki Otomo, Nobuo Fuse, Kenichi Ishizawa, Motohiko Seimiya, Masahiko Shimura, Ryo Ichinohasama
BACKGROUND: Follicular lymphomas of the ocular adnexa are very rare in Japan, with only two reported cases. CASE: A 44-year-old woman visited our clinic for treatment of ocular adnexal tumors in both eyes. FINDINGS: Histologic examination showed that the neoplastic lesions consisted of atypical lymphoid cells, and the tentative diagnosis was malignant lymphoma. Immunophenotypic analyses by flow cytometry and immunohistochemistry showed that the atypical lymphoid cells expressed CD45, bcl-2, CD10, CD19, CD20, IgM, and kappa light chains...
2010: Clinical Ophthalmology
Qian Wang, Xiao-qiu Li, Xiong-zeng Zhu, Xiao-li Zhu, Hong-fen Lu, Tai-ming Zhang, Xiao-yan Zhou
OBJECTIVE: To evaluate the ancillary diagnostic value of IgH gene rearrangements in those B-cell lymphoproliferative disorder cases whom are difficult in making a final diagnosis. METHODS: IgH gene clonal rearrangements were retrospectively analyzed in a total of 77 diagnostically difficult B-cell lympho-proliferative patients. Standardized BIOMED-2 system IgH gene clonality assay kit targeting FR1, FR2, FR3 was used, followed by heteroduplex-polyacrylamide gel electrophoresis (PAGE) and silver nitrate staining...
May 2010: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
L Sibulesky, R Satyanarayana, D Menke, J H Nguyen
The transmission of malignancy from donor to recipient can have devastating outcomes. Therefore, careful examination of the thoracic cavity, abdominal organs, and lymphoid tissue is important. In this report, we have described a case of a healthy 37-year-old donor with no significant past medical history who was found to have a nodule in the liver allograft during the examination at the back table. The frozen section revealed atypical lymphoid hyperplasia. Further workup revealed a rare benign lesion in the liver known as reactive lymphoid hyperplasia...
June 2010: Transplantation Proceedings
Masaru Kojima, Naoya Nakamura, Hideaki Itoh, Ken Shimizu, Kazuhiko Shimizu, Hazuki Matsuda, Yoshio Tamaki, Nobuhide Masawa, Shigeo Nakamura
BACKGROUND AND STUDY AIM: Because of the small biopsy specimens in the Waldeyer's ring (WR) the differential diagnosis between Epstein-Barr virus (EBV)-associated lymphoproliferative disorder (LPD) and malignant lymphoma is occasionally difficult. We report here clinicopathological, immunohistochemical and genotypic findings of 9 cases of EBV-associated LPDs in WR. PATIENTS AND METHODS: Using formalin-fixed paraffin-embedded sections, histological analyses, immunohistochemistry, in situ hybridization and polymerase chain reaction were performed...
2010: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
Da Zhang, Maura F O'neil, Mark T Cunningham, Fang Fan, Mojtaba Olyaee, Linheng Li
The variable natural history of mucosa-associated lymphoid tissue (MALT) lymphoma poses a challenge in predicting clinical outcome. Since Wnt signaling, as indicated by nuclear localization of beta-catenin, is believed to be key in stem cell activation and stem cell self-renewal, we explored the possibility that it might have a predictive value in marginal zone lymphoma. We chose to analyze pbeta-catenin-S552 because its nuclear localization by immunohistochemistry appears to coincide with Wnt signaling-initiated tumorigenesis in intestinal and hematopoietic tissues...
May 2010: Leukemia & Lymphoma
Dario Tomasini, Clementina Zampatti, Giovanni Serio
Castleman's disease (CD) is an unusual lymphoid hyperplasia occurring in the mediastinal lymph nodes and, less frequently, in the neck lymph nodes. CD is classified clinically into a unicentric and a multicentric type, whereas three histomorphological variants are recognized: the hyaline vascular type, the intermediate type and the plasma cell type. We report the clinical and pathological features of a 54-year-old female suffering with multiple sclerosis and developing a lymph node hyaline-vascular type CD relapsing in the skin after 24 months...
August 2009: Journal of Cutaneous Pathology
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