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https://www.readbyqxmd.com/read/28325225/-unconventional-experiments-in-biology-and-medicine-with-optimized-design-based-on-quantum-like-correlations
#1
Francis Beauvais
In previous articles, a description of 'unconventional' experiments (e.g. in vitro or clinical studies based on high dilutions, 'memory of water' or homeopathy) using quantum-like probability was proposed. Because the mathematical formulations of quantum logic are frequently an obstacle for physicians and biologists, a modified modeling that rests on classical probability is described in the present article. This modeling is inspired from a relational interpretation of quantum physics that applies not only to microscopic objects, but also to macroscopic structures, including experimental devices and observers...
February 2017: Homeopathy: the Journal of the Faculty of Homeopathy
https://www.readbyqxmd.com/read/28273479/systems-biology-of-metabolism-a-driver-for-developing-personalized-and-precision-medicine
#2
REVIEW
Jens Nielsen
Systems biology uses mathematical models to analyze large datasets and simulate system behavior. It enables integrative analysis of different types of data and can thereby provide new insight into complex biological systems. Here will be discussed the challenges of using systems medicine for advancing the development of personalized and precision medicine to treat metabolic diseases like insulin resistance, obesity, NAFLD, NASH, and cancer. It will be illustrated how the concept of genome-scale metabolic models can be used for integrative analysis of big data with the objective of identifying novel biomarkers that are foundational for personalized and precision medicine...
March 7, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28255558/buparvaquone-nanostructured-lipid-carrier-development-of-an-affordable-delivery-system-for-the-treatment-of-leishmaniases
#3
Lis Marie Monteiro, Raimar Löbenberg, Paulo Cesar Cotrim, Gabriel Lima Barros de Araujo, Nádia Bou-Chacra
Buparvaquone (BPQ), a veterinary drug, was formulated as nanostructured lipid carriers (NLC) for leishmaniases treatment. The formulation design addressed poor water solubility of BPQ and lack of human drug delivery system. The DSC/TG and microscopy methods were used for solid lipids screening. Softisan® 154 showed highest BPQ solubility in both methods. The BPQ solubility in liquid lipids using HPLC revealed Miglyol® 812 as the best option. Response surface methodology (RSM) was used to identify the optimal Softisan154 : Miglyol 812 ratios (7 : 10 to 2 : 1) and Kolliphor® P188 and Tween® 80 concentration (>3...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28230815/conceptual-foundations-of-systems-biology-explaining-complex-cardiac-diseases
#4
REVIEW
George E Louridas, Katerina G Lourida
Systems biology is an important concept that connects molecular biology and genomics with computing science, mathematics and engineering. An endeavor is made in this paper to associate basic conceptual ideas of systems biology with clinical medicine. Complex cardiac diseases are clinical phenotypes generated by integration of genetic, molecular and environmental factors. Basic concepts of systems biology like network construction, modular thinking, biological constraints (downward biological direction) and emergence (upward biological direction) could be applied to clinical medicine...
February 21, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/28222860/highly-efficient-chiral-separation-of-amlodipine-enantiomers-via-triple-recognition-hollow-fiber-membrane-extraction
#5
Shenzhi Lai, Shaotan Tang, Jiaqi Xie, Changqun Cai, Xiaoming Chen, Chunyan Chen
In this study, a triple recognition chiral extraction process has been developed to separate (S)-amlodipine from racemic raw medicine, based on the combination of molecularly imprinted hollow fiber membrane and cross-flow biphasic recognition extraction. The chiral separation process was operated in a dismountable hollow fiber module coated with molecularly imprinted polymer, and the cross-flow extraction was applied with d-tartaric acid in feed phase and sulfobutyl ether-β-cyclodextrin in stripping phase...
February 14, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28218249/complexity-variability-assessment-of-nonlinear-time-varying-cardiovascular-control
#6
Gaetano Valenza, Luca Citi, Ronald G Garcia, Jessica Noggle Taylor, Nicola Toschi, Riccardo Barbieri
The application of complex systems theory to physiology and medicine has provided meaningful information about the nonlinear aspects underlying the dynamics of a wide range of biological processes and their disease-related aberrations. However, no studies have investigated whether meaningful information can be extracted by quantifying second-order moments of time-varying cardiovascular complexity. To this extent, we introduce a novel mathematical framework termed complexity variability, in which the variance of instantaneous Lyapunov spectra estimated over time serves as a reference quantifier...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28166081/the-art-of-pharmacotherapy-reflections-on-pharmacophobia
#7
Jose de Leon, Carlos De Las Cuevas
PURPOSE/BACKGROUND: This commentary deals with the neglected issue of the art of psychopharmacology by recounting the authors' journeys. METHODS/PROCEDURES: First, a model of medical science situated within the history of medicine is described including (1) a limitation of the mathematical model of science, (2) the distinction between mechanistic science and mathematical science, (3) how this distinction is applied to medicine, and (4) how this distinction is applied to explain pharmacology to psychiatrists...
February 3, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28150316/facilitate-treatment-adjustment-after-overdosing-another-step-toward-21st-century-medicine
#8
Gilbert Koch, Johannes Schropp, Marc Pfister
Overdosing occurs frequently because of prescription errors in neonates, infants, children, adolescents, and adults. Currently there is no quantitative approach that can be used by clinicians to adjust dosing so that toxic drug concentrations can be brought back to levels observed with safe and efficacious therapeutic doses. We present a mathematical solution that offers the time between last overdosing and next therapeutic dose to achieve therapeutic drug concentrations as soon as possible. To facilitate applications of this solution in clinical practice, a minimal amount of information has to be provided, and no simulations are necessary to compute the optimal waiting time...
February 2, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28132437/graph-based-optimization-of-epitope-coverage-for-vaccine-antigen-design
#9
James Theiler, Bette Korber
Epigraph is a recently developed algorithm that enables the computationally efficient design of single or multi-antigen vaccines to maximize the potential epitope coverage for a diverse pathogen population. Potential epitopes are defined as short contiguous stretches of proteins, comparable in length to T-cell epitopes. This optimal coverage problem can be formulated in terms of a directed graph, with candidate antigens represented as paths that traverse this graph. Epigraph protein sequences can also be used as the basis for designing peptides for experimental evaluation of immune responses in natural infections to highly variable proteins...
January 29, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28120903/optimal-down-regulation-of-mrna-translation
#10
Yoram Zarai, Michael Margaliot, Tamir Tuller
Down regulation of mRNA translation is an important problem in various bio-medical domains ranging from developing effective medicines for tumors and for viral diseases to developing attenuated virus strains that can be used for vaccination. Here, we study the problem of down regulation of mRNA translation using a mathematical model called the ribosome flow model (RFM). In the RFM, the mRNA molecule is modeled as a chain of n sites. The flow of ribosomes between consecutive sites is regulated by n + 1 transition rates...
January 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28094427/minimalism-in-art-medical-science-and-neurosurgery
#11
Ali İhsan Ökten
The word ''minimalism'' is a word derived from French the word ''minimum''. Whereas the lexical meaning of minimum is ''the least or the smallest quantity necessary for something'', its expression in mathematics can be described as ''the lowest step a variable number can descend, least, minimal''. Minimalism, which advocates an extreme simplicity of the artistic form, is a current in modern art and music whose origins go to 1960s and which features simplicity and objectivity. Although art, science and philosophy are different disciplines, they support each other from time to time, sometimes they intertwine and sometimes they copy each other...
December 21, 2016: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28092955/flow-optimization-in-vascular-networks
#12
Radu C Cascaval, Ciro D'Apice, Maria Pia D'Arienzo, Rosanna Manzo
The development of mathematical models for studying phenomena observed in vascular networks is very useful for its potential applications in medicine and physiology. Detailed 3D studies of flow in the arterial system based on the Navier-Stokes equations require high computational power, hence reduced models are often used, both for the constitutive laws and the spatial domain. In order to capture the major features of the phenomena under study, such as variations in arterial pressure and flow velocity, the resulting PDE models on networks require appropriate junction and boundary conditions...
June 1, 2017: Mathematical Biosciences and Engineering: MBE
https://www.readbyqxmd.com/read/28091786/a-new-look-at-the-drug-resistance-investigation-of-uropathogenic-e-coli-strains
#13
Wioletta Adamus-Białek, Łukasz Lechowicz, Anna B Kubiak-Szeligowska, Monika Wawszczak, Ewelina Kamińska, Magdalena Chrapek
Bacterial drug resistance and uropathogenic tract infections are among the most important issues of current medicine. Uropathogenic Escherichia coli strains are the primary factor of this issue. This article is the continuation of the previous study, where we used Kohonen relations to predict the direction of drug resistance. The characterized collection of uropathogenic E. coli strains was used for microbiological (the disc diffusion method for antimicrobial susceptibility testing), chemical (ATR/FT-IR) and mathematical (artificial neural networks, Ward's hierarchical clustering method, the analysis of distributions of inhibition zone diameters for antibiotics, Cohen's kappa measure of agreement) analysis...
February 2017: Molecular Biology Reports
https://www.readbyqxmd.com/read/28087422/nano-qsar-in-cell-biology-model-of-cell-viability-as-a-mathematical-function-of-available-eclectic-data
#14
Alla P Toropova, Andrey A Toropov
The prediction of biochemical endpoints is an important task of the modern medicinal chemistry, cell biology, and nanotechnology. Simplified molecular input-line entry system (SMILES) is a tool for representation of the molecular structure. In particular, SMILES can be used to build up the quantitative structure - property/activity relationships (QSPRs/QSARs). The QSPR/QSAR is a tool to predict an endpoint for a new substance, which has not been examined in experiment. Quasi-SMILES are representation of eclectic data related to an endpoint...
January 11, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28076681/computational-modeling-of-neurotransmitter-release-evoked-by-electrical-stimulation-nonlinear-approaches-to-predicting-stimulation-evoked-dopamine-release
#15
James K Trevathan, Ali Yousefi, Hyung Ook Park, John J Bartoletta, Kip A Ludwig, Kendall H Lee, J Luis Lujan
Neurochemical changes evoked by electrical stimulation of the nervous system have been linked to both therapeutic and undesired effects of neuromodulation therapies used to treat obsessive-compulsive disorder, depression, epilepsy, Parkinson's disease, stroke, hypertension, tinnitus, and many other indications. In fact, interest in better understanding the role of neurochemical signaling in neuromodulation therapies has been a focus of recent government- and industry-sponsored programs whose ultimate goal is to usher in an era of personalized medicine by creating neuromodulation therapies that respond to real-time changes in patient status...
February 6, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28063987/a-mathematical-model-for-the-determination-of-forming-tissue-moduli-in-needled-nonwoven-scaffolds
#16
João S Soares, Will Zhang, Michael S Sacks
Formation of engineering tissues (ET) remains an important scientific area of investigation for both clinical translational and mechanobiological studies. Needled-nonwoven (NNW) scaffolds represent one of the most ubiquitous biomaterials based on their well-documented capacity to sustain tissue formation and the unique property of substantial construct stiffness amplification, the latter allowing for very sensitive determination of forming tissue modulus. Yet, their use in more fundamental studies is hampered by the lack of: (1) substantial understanding of the mechanics of the NNW scaffold itself under finite deformations and means to model the complex mechanical interactions between scaffold fibers, cells, and de novo tissue; and (2) rational models with reliable predictive capabilities describing their evolving mechanical properties and their response to mechanical stimulation...
March 15, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28057368/genomic-translational-research-paving-the-way-to-individualized-cardiac-functional-analyses-and-personalized-cardiology
#17
REVIEW
Ares Pasipoularides
For most of Medicine's past, the best that physicians could do to cope with disease prevention and treatment was based on the expected response of an average patient. Currently, however, a more personalized/precise approach to cardiology and medicine in general is becoming possible, as the cost of sequencing a human genome has declined substantially. As a result, we are witnessing an era of precipitous advances in biomedicine and bourgeoning understanding of the genetic basis of cardiovascular and other diseases, reminiscent of the resurgence of innovations in physico-mathematical sciences and biology-anatomy-cardiology in the Renaissance, a parallel time of radical change and reformation of medical knowledge, education and practice...
March 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28048759/tu-a-207b-00-imaging-genomics-associations-and-biological-correlates-of-radiomics
#18
Yitan Zhu
With the growth of quantitative imaging and quantitative image analysis, image-based biomarkers (i.e. image-based phenotypes) are becoming potential descriptors in personalized medicine as well as in cancer discovery research. Genomic study measures molecular cancer status and provides abundant information about cancer development mechanism. There is a need to understand the relationship between the image-based cancer phenotypes (from radiomics) and the underlying molecular and genomic system. Imaging scientists and genomic scientists need to be able to speak the same language in this common era of Big Data...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048333/mo-a-209-01-aapm-journal-finances-facts-figures-and-fundamentals
#19
S Armato
Scientific publishing is a major endeavor of the AAPM. Although publishing requires substantial resources, it has the potential to generate both reputation and revenue to further the missions of our society. The AAPM owns and publishes two journals: Medical Physics and the Journal of Applied Clinical Medical Physics (JACMP). Medical Physics, with the tagline "The international journal of medical physics research and practice," publishes research concerned with the application of physics and mathematics to the solution of problems in medicine and human biology, with an emphasis on theoretical and experimental approaches...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047682/mo-a-209-02-a-tale-of-two-journals-open-access-and-subscription-based-publications
#20
J Bourland
Scientific publishing is a major endeavor of the AAPM. Although publishing requires substantial resources, it has the potential to generate both reputation and revenue to further the missions of our society. The AAPM owns and publishes two journals: Medical Physics and the Journal of Applied Clinical Medical Physics (JACMP). Medical Physics, with the tagline "The international journal of medical physics research and practice," publishes research concerned with the application of physics and mathematics to the solution of problems in medicine and human biology, with an emphasis on theoretical and experimental approaches...
June 2016: Medical Physics
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