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epstein barr gene

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https://www.readbyqxmd.com/read/29050259/characterization-of-the-subcellular-localization-of-epstein-barr-virus-encoded-proteins-in-live-cells
#1
Mingsheng Cai, Zongmin Liao, Tao Chen, Ping Wang, Xingmei Zou, Yuanfang Wang, Zuo Xu, Si Jiang, Jinlu Huang, Daixiong Chen, Tao Peng, Gengde Hong, Meili Li
Epstein-Barr virus (EBV) is the pathogenic factor of numerous human tumors, yet certain of its encoded proteins have not been studied. As a first step for functional identification, we presented the construction of a library of expression constructs for most of the EBV encoded proteins and an explicit subcellular localization map of 81 proteins encoded by EBV in mammalian cells. Viral open reading frames were fused with enhanced yellow fluorescent protein (EYFP) tag in eukaryotic expression plasmid then expressed in COS-7 live cells, and protein localizations were observed by fluorescence microscopy...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049190/chronic-active-epstein-barr-virus-infection-as-the-initial-symptom-in-a-janus-kinase-3-deficiency-child-case-report-and-literature-review
#2
Linqing Zhong, Wei Wang, Mingsheng Ma, Lijuan Gou, Xiaoyan Tang, Hongmei Song
RATIONALE: With the progress of sequencing technology, an increasing number of atypical primary immunodeficiency (PID) patients have been discovered, including Janus kinase 3 (JAK3) gene deficiency. PATIENT CONCERNS: We report a patient who presented with chronic active Epstein-Barr virus (CAEBV) infection but responded poorly to treatment with ganciclovir. DIAGNOSES: Next-generation sequencing (NGS) was performed, including all known PID genes, after which Sanger sequencing was performed to verify the results...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29046940/gastric-cancer-immunohistochemical-classification-of-molecular-subtypes-and-their-association-with-clinicopathological-characteristics
#3
Eva-Maria Birkman, Naziha Mansuri, Samu Kurki, Annika Ålgars, Minnamaija Lintunen, Raija Ristamäki, Jari Sundström, Olli Carpén
Gastric cancer is traditionally divided into intestinal and diffuse histological subtypes, but recent molecular analyses have led to novel classification proposals based on genomic alterations. While the intestinal- and diffuse-type tumours are distinguishable from each other at the molecular level, intestinal-type tumours have more diverse molecular profile. The technology required for comprehensive molecular analysis is expensive and not applicable for routine clinical diagnostics. In this study, we have used immunohistochemistry and in situ hybridisation in molecular classification of gastric adenocarcinomas with an emphasis on the intestinal subtype...
October 19, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29038422/trim29-promotes-dna-virus-infections-by-inhibiting-innate-immune-response
#4
Junji Xing, Ao Zhang, Hua Zhang, Jin Wang, Xian Chang Li, Mu-Sheng Zeng, Zhiqiang Zhang
Many double-stranded DNA viruses, such as Epstein-Barr virus, can establish persistent infection, but the underlying virus-host interactions remain poorly understood. Here we report that in human airway epithelial cells Epstein-Barr virus induces TRIM29, a member of the TRIM family of proteins, to inhibit innate immune activation. Knockdown of TRIM29 in airway epithelial cells enhances type I interferon production, and in human nasopharyngeal carcinoma cells results in almost complete Epstein-Barr virus clearance...
October 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/29037489/latent-hiv-1-tar-regulates-7sk-responsive-p-tefb-target-genes-and-targets-cellular-immune-responses-in-the-absence-of-tat
#5
Sebastian Eilebrecht, Bernd-Joachim Benecke, Arndt G Benecke
The transactivating response element (TAR) structure of the nascent HIV-1 transcript is critically involved in the recruitment of inactive positive transcription elongation factor b (P-TEFb) to the promoter proximal paused RNA polymerase II. The viral transactivator Tat is responsible for subsequent P-TEFb activation in order to start efficient viral transcription elongation. In the absence of the viral transactivator of transcription (Tat), e.g., during latency or in early stages of HIV transcription, TAR mediates an interaction of P-TEFb with its inhibitor hexamethylene bis-acetamide-inducible proteins 1 (HEXIM1), keeping P-TEFb in its inactive form...
October 13, 2017: Genomics, Proteomics & Bioinformatics
https://www.readbyqxmd.com/read/29034771/genome-wide-analysis-of-epstein-barr-virus-identifies-variants-and-genes-associated-with-gastric-carcinoma-and-population-structure
#6
Youyuan Yao, Miao Xu, Liming Liang, Haojiong Zhang, Ruihua Xu, Qisheng Feng, Lin Feng, Bing Luo, Yi-Xin Zeng
Epstein-Barr virus is a ubiquitous virus and is associated with several human malignances, including the significant subset of gastric carcinoma, Epstein-Barr virus-associated gastric carcinoma. Some Epstein-Barr virus-associated diseases are uniquely prevalent in populations with different geographic origins. However, the features of the disease and geographically associated Epstein-Barr virus genetic variation as well as the roles that the variation plays in carcinogenesis and evolution remain unclear. Therefore, in this study, we sequenced 95 geographically distinct Epstein-Barr virus isolates from Epstein-Barr virus-associated gastric carcinoma biopsies and saliva of healthy donors to detect variants and genes associated with gastric carcinoma and population structure from a genome-wide spectrum...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29024646/the-epstein-barr-virus-regulome-in-lymphoblastoid-cells
#7
Sizun Jiang, Hufeng Zhou, Jun Liang, Catherine Gerdt, Chong Wang, Liangru Ke, Stefanie C S Schmidt, Yohei Narita, Yijie Ma, Shuangqi Wang, Tyler Colson, Benjamin Gewurz, Guoliang Li, Elliott Kieff, Bo Zhao
Epstein-Barr virus (EBV) transforms B cells to continuously proliferating lymphoblastoid cell lines (LCLs), which represent an experimental model for EBV-associated cancers. EBV nuclear antigens (EBNAs) and LMP1 are EBV transcriptional regulators that are essential for LCL establishment, proliferation, and survival. Starting with the 3D genome organization map of LCL, we constructed a comprehensive EBV regulome encompassing 1,992 viral/cellular genes and enhancers. Approximately 30% of genes essential for LCL growth were linked to EBV enhancers...
October 11, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28990284/the-oncogenic-role-of-epstein-barr-virus-encoded-micrornas-in-epstein-barr-virus-associated-gastric-carcinoma
#8
REVIEW
Jinglin Zhang, Tingting Huang, Yuhang Zhou, Alfred S L Cheng, Jun Yu, Ka Fai To, Wei Kang
Epstein-Barr virus (EBV) infection is detected in various epithelial malignancies, such as nasopharyngeal carcinoma (NPC) and gastric cancer (GC). EBV comprises some unique molecular features and encodes viral genes and microRNAs (miRNAs) by its own DNA sequence. EBV genes are required to maintain latency and contribute to oncogenic property. miRNAs encoded by EBV have been shown to contribute to initiation and progression of EBV-related malignancies. By a number of genomic profiling studies, some EBV miRNAs were confirmed to be highly expressed in EBV-associated gastric cancer (EBVaGC) samples and cell lines...
October 9, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28985762/a-study-of-epstein-barr-virus-infection-in-the-chinese-tree-shrew-tupaia-belangeri-chinensis
#9
Zhi Wang, Xiang Yi, Long Du, Hong Wang, Jie Tang, Menglin Wang, Chenglin Qi, Heng Li, Yongjing Lai, Wei Xia, Anzhou Tang
BACKGROUND: Epstein-Barr virus (EBV) is closely associated with many human diseases, including a variety of deadly human malignant tumours. However, due to the lack of ideal animal models,the biological characteristics of EBV, particularly its function in tumourigenesis, have not been determined. Chinese tree shrews (Tupaia belangeri chinensis), which are similar to primates, have been used to establish a variety of animal models and have recently received much attention. Here, we established tree shrews as a model for EBV infection by intravenous injection...
October 6, 2017: Virology Journal
https://www.readbyqxmd.com/read/28977893/combination-of-betulinic-acid-and-chidamide-synergistically-inhibits-epstein-barr-virus-replication-through-over-generation-of-reactive-oxygen-species
#10
Haibing Yu, Hongyu Zhang, Zhigang Chu, Qiongfang Ruan, Xueru Chen, Danli Kong, Xiaodong Huang, Huawen Li, Huanwen Tang, Hongjin Wu, Yifei Wang, Weiguo Xie, Yuanling Ding, Paul Yao
Epstein-Barr virus (EBV) has widely infected more than 90% of human populations. Currently, there is no efficient way to remove the virus because the EBV carriers are usually in a latent stage that allows them to escape the immune system and common antiviral drugs. In the effort to develop an efficient strategy for the removal of the EBV virus, we have shown that betulinic acid (BA) slightly suppresses EBV replication through SOD2 suppression with subsequent reactive oxygen species (ROS) generation and DNA damage in EBV-transformed LCL (lymphoblastoid cell line) cells...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28968560/human-b-cells-fail-to-secrete-type-i-interferons-upon-cytoplasmic-dna-exposure
#11
Anna M Gram, Chenglong Sun, Sanne L Landman, Timo Oosenbrug, Hester J Koppejan, Mark J Kwakkenbos, Rob C Hoeben, Søren R Paludan, Maaike E Ressing
Most cells are believed to be capable of producing type I interferons (IFN I) as part of an innate immune response against, for instance, viral infections. In macrophages, IFN I is potently induced upon cytoplasmic exposure to foreign nucleic acids. Infection of these cells with herpesviruses leads to triggering of the DNA sensors interferon-inducible protein 16 (IFI16) and cyclic GMP-AMP (cGAMP) synthase (cGAS). Thereby, the stimulator of interferon genes (STING) and the downstream molecules TANK-binding kinase 1 (TBK1) and interferon regulatory factor 3 (IRF3) are sequentially activated culminating in IFN I secretion...
September 29, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28968461/ebf1-binds-to-ebna2-and-promotes-the-assembly-of-ebna2-chromatin-complexes-in-b-cells
#12
Laura V Glaser, Simone Rieger, Sybille Thumann, Sophie Beer, Cornelia Kuklik-Roos, Dietmar E Martin, Kerstin C Maier, Marie L Harth-Hertle, Björn Grüning, Rolf Backofen, Stefan Krebs, Helmut Blum, Ralf Zimmer, Florian Erhard, Bettina Kempkes
Epstein-Barr virus (EBV) infection converts resting human B cells into permanently proliferating lymphoblastoid cell lines (LCLs). The Epstein-Barr virus nuclear antigen 2 (EBNA2) plays a key role in this process. It preferentially binds to B cell enhancers and establishes a specific viral and cellular gene expression program in LCLs. The cellular DNA binding factor CBF1/CSL serves as a sequence specific chromatin anchor for EBNA2. The ubiquitous expression of this highly conserved protein raises the question whether additional cellular factors might determine EBNA2 chromatin binding selectively in B cells...
October 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28960205/coordinated-repression-of-bim-and-puma-by-epstein-barr-virus-latent-genes-maintains-the-survival-of-burkitt-lymphoma-cells
#13
Leah Fitzsimmons, Andrew J Boyce, Wenbin Wei, Catherine Chang, Deborah Croom-Carter, Rosemary J Tierney, Marco J Herold, Andrew I Bell, Andreas Strasser, Gemma L Kelly, Martin Rowe
While the association of Epstein-Barr virus (EBV) with Burkitt lymphoma (BL) has long been recognised, the precise role of the virus in BL pathogenesis is not fully resolved. EBV can be lost spontaneously from some BL cell lines, and these EBV-loss lymphoma cells reportedly have a survival disadvantage. Here we have generated an extensive panel of EBV-loss clones from multiple BL backgrounds and examined their phenotype comparing them to their isogenic EBV-positive counterparts. We report that, while loss of EBV from BL cells is rare, it is consistently associated with an enhanced predisposition to undergo apoptosis and reduced tumorigenicity in vivo...
September 29, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28950226/the-epstein-barr-virus-mir-bhrf1-micrornas-regulate-viral-gene-expression-in-cis
#14
Brigid Chiyoko Poling, Alexander M Price, Micah A Luftig, Bryan R Cullen
The Epstein-Barr virus (EBV) miR-BHRF1 microRNA (miRNA) cluster has been shown to facilitate B-cell transformation and promote the rapid growth of the resultant lymphoblastoid cell lines (LCLs). However, we find that expression of physiological levels of the miR-BHRF1 miRNAs in LCLs transformed with a miR-BHRF1 null mutant (∆123) fails to increase their growth rate. We demonstrate that the pri-miR-BHRF1-2 and 1-3 stem-loops are present in the 3'UTR of transcripts encoding EBNA-LP and that excision of pre-miR-BHRF1-2 and 1-3 by Drosha destabilizes these mRNAs and reduces expression of the encoded protein...
September 23, 2017: Virology
https://www.readbyqxmd.com/read/28946568/protein-expression-profiling-in-the-hippocampus-after-focal-cerebral-ischemia-injury-in-rats
#15
Lichan He, Rui He, Ruihua Liang, Yi Li, Xiaoqiang Li, Chuqiao Li, Suping Zhang
In this study, we aimed to explore protein expression profiles in the hippocampus of rats after the induction of focal ischemia injury. Forty SD male rats were randomly divided into 4 groups, with ten rats per group: the control, Day 3, Day 7, and Day 14 after the ischemia injury surgery. Focal cortical ischemia was induced in thirty rats by photothrombosis of the cortical microvessels. After surgery, the induction of ischemia was confirmed by the measurement of infarct size using 2,3,5-triphenyltetrazolium chloride (TTC) staining...
September 20, 2017: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/28943520/epstein-barr-virus-driven-promoter-hypermethylated-genes-in-gastric-cancer
#16
J Yu, K F To, Q Y Liang
No abstract text is available yet for this article.
August 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28940489/polymorphisms-in-homologous-recombination-repair-genes-and-the-risk-and-survival-of-breast-cancer
#17
Yu-Huang Liao, Jun-Ting Ren, Wei Zhang, Zheng-Zheng Zhang, Ying Lin, Feng-Xi Su, Wei-Hua Jia, Lu-Ying Tang, Ze-Fang Ren
BACKGROUND: Immunoglobulin (Ig)A antibody of Epstein-Barr virus (EBV) was found to associate with breast cancer (BC), whereas IgA positivity was related to a series of genetic markers in the genes of homologous recombination repair system (HRRs). We assessed the associations of the polymorphisms in HRR genes with the risk and survival of BC. METHODS: A case-control study was conducted with 1551 bc cases and 1605 age-matched healthy controls between October 2008 and March 2012 in the Guangzhou Breast Cancer Study (GZBCS), China, and the case population were followed up until 31 January 2016...
September 23, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/28934430/epstein-barr-virus-type-2-infects-t-cells-in-healthy-kenyan-children
#18
Carrie B Coleman, Ibrahim I Daud, Sidney O Ogolla, Julie A Ritchie, Nicholas A Smith, Peter O Sumba, Arlene E Dent, Rosemary Rochford
Background: The 2 strains of Epstein-Barr virus (EBV), EBV type 1 (EBV-1) and EBV-2, differ in latency genes, suggesting that they use distinct mechanisms to establish latency. We previously reported that EBV-2 infects T cells in vitro. In this study, we tested the possibility that EBV-2 infects T cells in vivo. Methods: Purified T-cell fractions isolated from children positive for EBV-1 or EBV-2 and their mothers were examined for the presence of EBV and for EBV type...
September 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28920417/effects-of-deoxynivalenol-and-zearalenone-contaminated-feed-on-the-gene-expression-profiles-in-the-kidneys-of-piglets
#19
Kondreddy Eswar Reddy, Woong Lee, Jin Young Jeong, Yookyung Lee, Hyun-Jeong Lee, Min Seok Kim, Dong-Woon Kim, Dongjo Yu, Ara Cho, Young Kyoon Oh, Sung Dae Lee
Objective: Fusarium mycotoxins deoxynivalenol (DON) and zearalenone (ZEN), common contaminants in the feed of farm animals, cause immune function impairment and organ inflammation. Consequently, the main objective of this study was to elucidate DON and ZEN effects on the mRNA expression of pro-inflammatory cytokines and other immune related genes in the kidneys of piglets. Methods: Fifteen 6-week-old piglets were randomly assigned to three dietary treatments for 4 weeks: control diet, and diets contaminated with either 8 mg DON/kg feed or 0...
September 18, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28915562/detecting-the-genetic-link-between-alzheimer-s-disease-and-obesity-using-bioinformatics-analysis-of-gwas-data
#20
Qi-Shuai Zhuang, Hao Zheng, Xiao-Dan Gu, Liang Shen, Hong-Fang Ji
Alzheimer's disease (AD) represents the major form of dementia in the elderly. In recent years, accumulating evidence indicate that obesity may act as a risk factor for AD, while the genetic link between the two conditions remains unclear. This bioinformatics analysis aimed to detect the genetic link between AD and obesity on single nucleotide polymorphisms (SNPs), gene, and pathway levels based on genome-wide association studies data. A total of 31 SNPs were found to be shared by AD and obesity, which were linked to 7 genes...
August 22, 2017: Oncotarget
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