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https://www.readbyqxmd.com/read/28915543/effects-of-diisononyl-phthalate-on-danio-rerio-reproduction
#1
Stefania Santangeli, Francesca Maradonna, Maya Zanardini, Valentina Notarstefano, Giorgia Gioacchini, Isabel Forner-Piquer, Hamid Habibi, Oliana Carnevali
Di-isononyl phthalate (DiNP) is a high molecular weight phthalate commonly used as a plasticizer. It was introduced as a replacement for bis (2-ethylhexyl) phthalate (DEHP) which is used in the production of plasticized polyvinyl chloride (PVC). The purpose of this study was to investigate for the first time the effect of DiNP on female reproductive physiology in Danio rerio. Fish were exposed to five different doses of DiNP plus control (0 μg/L; 0.42 μg/L; 4.2 μg/L; 42 μg/L; 420 μg/L; 4200 μg/L) for a period of 21 days...
September 11, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28893856/distinct-and-cooperative-roles-of-amh-and%C3%A2-dmrt1-in-self-renewal-and-differentiation-of-male-germ-cells-in-zebrafish
#2
Qiaohong Lin, Jie Mei, Zhi Li, Xuemei Zhang, Li Zhou, Jian-Fang Gui
Spermatogenesis is a fundamental process in male reproductive biology, and depends on precise balance between self-renewal and differentiation of male germ cells. However, the regulative factors for controlling the balance are poorly understood. In this study, we examined the roles of amh and dmrt1 in male germ cell development by generating their mutants with Crispr/Cas9 technology in zebrafish. Amh mutant zebrafish displayed a female-biased sex ratio, and both male and female amh mutants developed hypertrophic gonads due to uncontrolled proliferation and impaired differentiation of germ cells...
September 11, 2017: Genetics
https://www.readbyqxmd.com/read/28892180/long-term-exposure-to-bisphenol-s-damages-the-visual-system-and-reduces-the-tracking-capability-of-male-zebrafish-danio-rerio
#3
Wenmin Liu, Xiaona Zhang, Penghao Wei, Hua Tian, Wei Wang, Shaoguo Ru
Bisphenol S (BPS) is widely detected in aquatic environments and in human bodies. BPS has reproductive and thyroid disrupting effects, but its effect on the visual system remains unknown. In the present study, zebrafish embryos were exposed to BPS at concentrations of 1, 10, 100 and 1000 μg l(-1) until 120 days post-fertilization in a semistatic system, and the effect of BPS on the visual behavior was examined using the optokinetic response and the optomotor response tests in male zebrafish. The retinal histology, mRNA expression of photoreceptor opsin genes (zfrho, zfblue, zfgr1, zfred and zfuv) and apoptosis-related genes (bax and bcl-2) were also assessed...
September 11, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28866668/emerging-roles-of-kisspeptin-in-sexual-and-emotional-brain-processing
#4
Alexander N Comninos, Waljit S Dhillo
<br>The emergence of kisspeptin as a crucial regulator of the hypothalamo-pituitary-gonadal (HPG) axis over the last 14 years has answered many questions as to the control of reproductive hormone secretion from the hypothalamus. More recently the role of kisspeptin outside the HPG axis has received increasing attention in the hope of delineating the pathways linking various sensory and social behaviours to reproduction. These studies, in a range of species from zebrafish to humans, have identified a role for kisspeptin in behavioural networks related to reproduction including olfaction, audition, fear, anxiety, mood and sexual arousal...
August 31, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28856758/the-gonadal-soma-controls-ovarian-follicle-proliferation-through-gsdf-in-zebrafish
#5
Yi-Lin Yan, Thomas Desvignes, Ruth BreMiller, Catherine Wilson, Danielle Dillon, Samantha High, Bruce Draper, Charles Loren Buck, John Postlethwait
BACKGROUND: Aberrant signaling between germ cells and somatic cells can lead to reproductive disease and depends on diffusible signals, including TGFB-family proteins. The TGFB-family protein Gsdf (gonadal soma derived factor) controls sex determination in some fish and is a candidate for mediating germ cell/soma signaling. RESULTS: Zebrafish expressed gsdf in somatic cells of bipotential gonads and expression continued in ovarian granulosa cells and testicular Sertoli cells...
August 30, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28834696/semicarbazide-disturbs-the-reproductive-system-of-male-zebrafish-danio-rerio-through-the-gabaergic-system
#6
Miao Yu, Yongliang Feng, Xiaona Zhang, Jun Wang, Hua Tian, Wei Wang, Shaoguo Ru
Semicarbazide (SMC), an emerging water contaminant, exerts anti-estrogenic effects in female zebrafish. However, the exact influence of SMC on male reproduction remains unclear. In this study, adult male zebrafish were exposed to 1-1000μg/L SMC in a semi-static system for 28 d prior to examining the testicular somatic index (TSI), testis histology, plasma sex hormone levels, and the transcription of genes involved in reproduction. The results showed that testicular morphology was altered and TSI was down-regulated by high concentrations of SMC (≥100μg/L and 1000μg/L, respectively)...
August 20, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28830046/fish-life-history-traits-are-affected-after-chronic-dietary-exposure-to-an-environmentally-realistic-marine-mixture-of-pcbs-and-pbdes
#7
Khaled Horri, Sébastien Alfonso, Xavier Cousin, Catherine Munschy, Véronique Loizeau, Salima Aroua, Marie-Laure Bégout, Bruno Ernande
Polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) are persistent organic pollutants that have been shown to affect fish life-history traits such as reproductive success, growth and survival. At the individual level, their toxicity and underlying mechanisms of action have been studied through experimental exposure. However, the number of experimental studies approaching marine environmental situations is scarce, i.e., in most cases, individuals are exposed to either single congeners, or single types of molecules, or high concentrations, so that results can hardly be transposed to natural populations...
August 18, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28783116/teratogenic-effects-of-topiramate-in-a-zebrafish-model
#8
Yu-Heng Lai, Yu-Ju Ding, David Moses, Yau-Hung Chen
Topiramate is commonly used for treating epilepsy in both children and adults. Recent clinical data suggests that administration of topiramate to women during pregnancy increases the risk of oral clefts in their offspring. To better understand the potential effects of topiramate, we dosed adult female zebrafish with topiramate, and investigated the altered morphologies in adult females and their offspring. It showed that topiramate-treated female fish had reduced oocyte maturation, and the survival rates of their offspring were seriously decreased during embryogenesis...
August 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28765643/mir-202-5p-is-a-novel-germ-plasm-specific-microrna-in-zebrafish
#9
Jing Zhang, Wei Liu, Yilin Jin, Peng Jia, Kuntong Jia, Meisheng Yi
Gametogenesis is a complicated biological process by which sperm and egg are produced for genetic transmission between generations. In many animals, the germline is segregated from the somatic lineage in early embryonic development through the specification of primordial germ cells (PGCs), the precursors of gametes for reproduction and fertility. In some species, such as fruit fly and zebrafish, PGCs are determined by the maternally provided germ plasm which contains various RNAs and proteins. Here, we identified a germ plasm/PGC-specific microRNA miR-202-5p for the first time in zebrafish...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28741210/effects-of-bpf-on-steroid-hormone-homeostasis-and-gene-expression-in-the-hypothalamic-pituitary-gonadal-axis-of-zebrafish
#10
Qian Yang, Xianhai Yang, Jining Liu, Wenjuan Ren, Yingwen Chen, Shubao Shen
Bisphenol F (BPF) has been frequently detected in various environmental compartments, and previous studies found that BPF exhibits similar estrogenic and anti-androgenic effects on the mammalian endocrine system to those of bisphenol A (BPA). However, the potential disrupting effects of BPF on aquatic organisms and the underling disrupting mechanisms have not been investigated. In this study, the potential disrupting mechanisms of BPF on the hypothalamic-pituitary-gonadal (HPG) axis and liver were probed by employing the OECD 21-day short-term fecundity assay in zebrafish...
July 25, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28671593/high-consumption-of-iron-exacerbates-hyperlipidemia-atherosclerosis-and-female-sterility-in-zebrafish-via-acceleration-of-glycation-and-degradation-of-serum-lipoproteins
#11
So-Hee Kim, Dhananjay Yadav, Suk-Jeong Kim, Jae-Ryong Kim, Kyung-Hyun Cho
Elevated serum iron level is linked with an increased risk of diabetes and atherosclerosis. However, the pathological mechanism by which iron affects serum lipoprotein levels is unknown. To elucidate the mechanism, a high dose of ferrous ion was applied (final 60 µM, 120 µM) to human serum lipoproteins, macrophages, and human dermal fibroblast (HDF) cells. Iron-treated lipoproteins showed loss of antioxidant ability along with protein degradation and multimerization, especially co-treatment with fructose (final 10 mM)...
July 2, 2017: Nutrients
https://www.readbyqxmd.com/read/28666956/coordination-of-cellular-differentiation-polarity-mitosis-and-meiosis-new-findings-from-early-vertebrate-oogenesis
#12
REVIEW
Yaniv M Elkouby, Mary C Mullins
A mechanistic dissection of early oocyte differentiation in vertebrates is key to advancing our knowledge of germline development, reproductive biology, the regulation of meiosis, and all of their associated disorders. Recent advances in the field include breakthroughs in the identification of germline stem cells in Medaka, in the cellular architecture of the germline cyst in mice, in a mechanistic dissection of chromosomal pairing and bouquet formation in meiosis in mice, in tracing oocyte symmetry breaking to the chromosomal bouquet of meiosis in zebrafish, and in the biology of the Balbiani body, a universal oocyte granule...
June 28, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28663543/nr3c1-null-mutant-zebrafish-are-viable-and-reveal-dna-binding-independent-activities-of-the-glucocorticoid-receptor
#13
N Facchinello, T Skobo, G Meneghetti, E Colletti, A Dinarello, N Tiso, R Costa, G Gioacchini, O Carnevali, F Argenton, L Colombo, L Dalla Valle
Glucocorticoids (GCs) play important roles in developmental and physiological processes through the transcriptional activity of their cognate receptor (Gr). Using CRISPR/Cas9 technology, we established a zebrafish null Gr mutant line and compared its phenotypes with wild type and a zebrafish line with partially silenced gr (gr (s357/s357) ). Homozygous gr (-/-) larvae are morphologically inconspicuous and, in contrast to GR (-/-) knockout mice, viable through adulthood, although with reduced fitness and early life survival...
June 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28649046/transgenerational-endocrine-disruption-and-neurotoxicity-in-zebrafish-larvae-after-parental-exposure-to-binary-mixtures-of-decabromodiphenyl-ether-bde-209-and-lead
#14
Lianguo Chen, Xianfeng Wang, Xiaohua Zhang, Paul K S Lam, Yongyong Guo, James C W Lam, Bingsheng Zhou
Polybrominated diphenyl ethers (PBDEs) and heavy metals are two key groups of electric and electronic equipment contaminants. Despite their co-occurrence in aquatic environments, their combined effects remain largely unknown, particularly under a chronic exposure regime. In the present study, adult zebrafish (Danio rerio) were exposed to environmentally relevant concentrations of BDE-209 and lead (Pb), or their binary mixtures, for 3 months. After chronic parental exposure, increased transfer of BDE-209 and Pb to the offspring eggs was activated in the coexposure groups, with BDE-197 being the predominant PBDE congener, indicating the dynamic metabolism of BDE-209 in parental zebrafish...
November 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28648994/dynamic-and-differential-expression-of-the-gonadal-aromatase-during-the-process-of-sexual-differentiation-in-a-novel-transgenic-cyp19a1a-egfp-zebrafish-line
#15
Nathalie Hinfray, Frédéric Sohm, Morgane Caulier, Edith Chadili, Benjamin Piccini, Camille Torchy, Jean-Marc Porcher, Yann Guiguen, François Brion
In zebrafish, there exists a clear need for new tools to study sex differentiation dynamic and its perturbation by endocrine disrupting chemicals. In this context, we developed and characterized a novel transgenic zebrafish line expressing green fluorescent protein (GFP) under the control of the zebrafish cyp19a1a (gonadal aromatase) promoter. In most gonochoristic fish species including zebrafish, cyp19a1a, the enzyme responsible for the synthesis of estrogens, has been shown to play a critical role in the processes of reproduction and sexual differentiation...
June 22, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28636878/lycium-barbarum-polysaccharide-alleviates-nonylphenol-exposure-induced-testicular-injury-in-juvenile-zebrafish
#16
Ze-Yong Tang, Dong Sun, Chun-Wei Qian, Qi Chen, Shun-Shan Duan, Sheng-Yun Sun
Nonylphenol is an endocrine disrupting chemicals that can disrupt the organisms' reproductive system, and exists widely in rivers and lakes. Lycium barbarum polysaccharide (LBP) is the main active constituent (about 10%) in Lycium barbarum, which is used to protect reproductive health. In this study, we investigated whether LBP can alleviate nonylphenol exposure induced testicular injury in juvenile zebrafish. We detected histological alteration, anti-oxidant enzyme profile and P450 gene transcription to assess LBP effect on testicular development...
November 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28634424/overexpression-and-knockdown-of-hypoxia-inducible-factor-1-disrupt-the-expression-of-steroidogenic-enzyme-genes-and-early-embryonic-development-in-zebrafish
#17
Tianfeng Tan, Richard Man Kit Yu, Rudolf Shiu Sun Wu, Richard Yuen Chong Kong
Hypoxia is an important environmental stressor leading to endocrine disruption and reproductive impairment in fish. Although the hypoxia-inducible factor 1 (HIF-1) is known to regulate the transcription of various genes mediating oxygen homeostasis, its role in modulating steroidogenesis-related gene expression remains poorly understood. In this study, the regulatory effect of HIF-1 on the expression of 9 steroidogenic enzyme genes was investigated in zebrafish embryos using a "gain-of-function and loss-of-function" approach...
2017: Gene Regulation and Systems Biology
https://www.readbyqxmd.com/read/28621416/all-in-one-integrating-cell-polarity-meiosis-mitosis-and-mechanical-forces-in-early-oocyte-differentiation-in-vertebrates
#18
Yaniv M Elkouby
While the differentiation of oocytes is key for embryonic development, and its investigation is crucial for advancing our understanding of human reproduction and fertility, many fundamental questions in oogenesis have been long standing. However, recent technical advances have led to several breakthroughs mainly in mice and zebrafish. Here I review these recent findings, including regulation and organization of the germline cyst, the mechanistics of chromosomal pairing, establishment of cell polarity, and formation of a universal mRNA-protein (mRNP) granule called the Balbiani body...
2017: International Journal of Developmental Biology
https://www.readbyqxmd.com/read/28620015/genetic-editing-of-the-androgen-receptor-contributes-to-impaired-male-courtship-behavior-in-zebrafish
#19
Lengxob Yong, Zayer Thet, Yong Zhu
Elucidating the genes that contribute to behavioral variation has become an important endeavor in behavioral studies. While advances in genomics have narrowed down candidate genes, functionally validating them has been lagging, partly because of challenges associated with rapid gene manipulations. Consequently, few studies have demonstrated causal genetic changes linked to behaviors. The 'gene editing revolution' has offered unprecedented opportunities to interrogate candidate genes responsible for critical behaviors...
June 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28611209/the-highly-overlapping-actions-of-lh-signaling-and-fsh-signaling-on-zebrafish-spermatogenesis
#20
Yuxin Xie, Lianhe Chu, Yun Liu, Kathy W Y Sham, Jianzhen Li, Christopher H K Cheng
Gonadotropin signaling plays a pivotal role in the spermatogenesis of vertebrates, but how gonadotropins regulate the process in non-mammalian species remains elusive. Using a gene knockout approach in zebrafish, we have previously demonstrated the non-canonical action of gonadotropin signaling on spermatogenesis by analyzing four single mutant lines (lhb, lhr, fshb and fshr) and three double mutant lines (lhb;fshb, lhr;fshr and fshb;lhr). In this study, we further investigated the actions of gonadotropins on the testis by establishing three other double mutant zebrafish lines (lhb;lhr, fshb;fshr and lhb;fshr)...
June 13, 2017: Journal of Endocrinology
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