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https://www.readbyqxmd.com/read/29159033/interstitial-pneumonia-caused-by-dabigatran
#1
Toyoshi Yanagihara, Norio Yamamoto, Yasuaki Kotetsu, Naoki Hamada, Eiji Harada, Kunihiro Suzuki, Kayo Ijichi, Yoshinao Oda, Yoichi Nakanishi
We describe the case of a 73-year-old man who experienced dry cough and exertional dyspnea after dabigatran administration. Chest radiographs revealed the development of bilateral consolidative and ground glass opacity, and transbronchial lung biopsy showed organized materials in the alveolar spaces with moderate inflammatory infiltrate and focal fibrosis. Lung opacity gradually disappeared after discontinuing dabigatran. To date, there has been only one report regarding dabigatran-induced lung injury, except for alveolar hemorrhage and eosinophilic pneumonia...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29156147/electromagnetic-navigational-bronchoscopy-versus-ct-guided-percutaneous-sampling-of-peripheral-indeterminate-pulmonary-nodules-a-cohort-study
#2
Kavita M Bhatt, Yasmeen K Tandon, Ruffin Graham, Charles T Lau, Jason K Lempel, Joseph T Azok, Peter J Mazzone, Erika Schneider, Nancy A Obuchowski, Michael A Bolen
Purpose To compare the diagnostic yield and complication rates of electromagnetic navigational bronchoscopic (ENB)-guided and computed tomography (CT)-guided percutaneous tissue sampling of lung nodules. Materials and Methods Retrospectively identified were 149 patients sampled percutaneously with CT guidance and 146 patients who underwent ENB with transbronchial biopsy of a lung lesion between 2013 and 2015. Clinical data, incidence of complications, and nodule pathologic analyses were assessed through electronic medical record review...
November 20, 2017: Radiology
https://www.readbyqxmd.com/read/29154972/impact-of-rapid-on-site-cytological-evaluation-rose-on-the-diagnostic-yield-of-transbronchial-needle-aspiration-during-mediastinal-lymph-node-sampling-systematic-review-and-meta-analysis
#3
Inderpaul Singh Sehgal, Sahajal Dhooria, Ashutosh Nath Aggarwal, Ritesh Agarwal
BACKGROUND: Whether the use of rapid onsite cytological evaluation (ROSE) increases the diagnostic yield of transbronchial needle aspiration (TBNA) remains unclear. Herein, we perform a systematic review of studies describing the utility of ROSE in subjects undergoing TBNA. METHODS: Systematic review of PubMed, EmBase and Scopus databases for RCTs investigating the diagnostic yield of conventional TBNA (c-TBNA) or endobronchial ultrasound (EBUS)-TBNA, with or without ROSE, in subjects with mediastinal lymphadenopathy...
November 15, 2017: Chest
https://www.readbyqxmd.com/read/29153417/the-efficacy-of-transbronchial-needle-aspiration-with-endobronchial-ultrasonography-using-a-guide-sheath-for-peripheral-pulmonary-lesions-suspected-to-be-lung-cancer
#4
Ken Arimura, Yasuo Sekine, Kenzo Hiroshima, Akitoshi Sato, Mizue Hasegawa, Hideki Katsura, Etsuko Tagaya, Mitsuko Kondo, Jun Tamaoki
BACKGROUND: The efficacy of transbronchial needle aspiration (TBNA) with endobronchial ultrasonography using a guide sheath (EBUS-GS) for cases of peripheral pulmonary lesions (PPLs) has not been well established. The purpose of this study was to evaluate the efficacy of TBNA with EBUS-GS for PPLs. METHODS: We evaluated 130 patients suspected to have lung cancer who underwent transbronchial brushing (brushing), transbronchial biopsy (TBB), and TBNA with EBUS-GS...
November 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/29151522/a-case-of-large-cell-neuroendocrine-carcinoma-harboring-an-alk-rearrangement-with-response-to-alectinib
#5
Nobuyoshi Hayashi, Akihisa Fujita, Toyohiro Saikai, Hirotugu Takabatake, Mie Sotoshiro, Kyuutarou Sekine, Akihiko Kawana
Anaplastic lymphoma kinase (ALK) rearrangement is most commonly observed in lung adenocarcinoma in a subset of lung cancer. Large-cell neuroendocrine carcinoma (LCNEC) harboring an ALK rearrangement is very rare. Based on the findings from a transbronchial lung biopsy, a 75-year-old non-smoking woman was diagnosed with LCNEC with multiple liver and bone metastases. After seven cycles of cytotoxic chemotherapy, her genotype testing demonstrated ALK rearrangement. Subsequently, she was administered alectinib and exhibited a partial response...
November 20, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29149880/analytical-performance-of-envisia-a-genomic-classifier-for-usual-interstitial-pneumonia
#6
Yoonha Choi, Jiayi Lu, Zhanzhi Hu, Daniel G Pankratz, Huimin Jiang, Manqiu Cao, Cristina Marchisano, Jennifer Huiras, Grazyna Fedorowicz, Mei G Wong, Jessica R Anderson, Edward Y Tom, Joshua Babiarz, Urooj Imtiaz, Neil M Barth, P Sean Walsh, Giulia C Kennedy, Jing Huang
BACKGROUND: Clinical guidelines specify that diagnosis of interstitial pulmonary fibrosis (IPF) requires identification of usual interstitial pneumonia (UIP) pattern. While UIP can be identified by high resolution CT of the chest, the results are often inconclusive, making surgical lung biopsy necessary to reach a definitive diagnosis (Raghu et al., Am J Respir Crit Care Med 183(6):788-824, 2011). The Envisia genomic classifier differentiates UIP from non-UIP pathology in transbronchial biopsies (TBB), potentially allowing patients to avoid an invasive procedure (Brown et al...
November 17, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29140122/lymphangioleiomyomatosis-diagnosis-and-management-high-resolution-chest-computed-tomography-transbronchial-lung-biopsy-and-pleural-disease-management-an-official-american-thoracic-society-japanese-respiratory-society-clinical-practice-guideline
#7
Nishant Gupta, Geraldine A Finlay, Robert M Kotloff, Charlie Strange, Kevin C Wilson, Lisa R Young, Angelo M Taveira-DaSilva, Simon R Johnson, Vincent Cottin, Steven A Sahn, Jay H Ryu, Kuniaki Seyama, Yoshikazu Inoue, Gregory P Downey, MeiLan K Han, Thomas V Colby, Kathryn A Wikenheiser-Brokamp, Cristopher A Meyer, Karen Smith, Joel Moss, Francis X McCormack
BACKGROUND: Recommendations regarding key aspects related to the diagnosis and pharmacological treatment of lymphangioleiomyomatosis (LAM) were recently published. We now provide additional recommendations regarding four specific questions related to the diagnosis of LAM and management of pneumothoraces in patients with LAM. METHODS: Systematic reviews were performed and then discussed by a multidisciplinary panel. For each intervention, the panel considered its confidence in the estimated effects, the balance of desirable (i...
November 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29137054/case-report-middle-aged-woman-from-ghana-with-unsteady-gait-and-enlarging-cerebellar-mass
#8
Bharat Bajantri, Sindhaghatta Venkatram, Masooma Niazi, Tushi Singh, Gilda Diaz-Fuentes
RATIONALE: Neurosarcoidosis (NS) is an uncommon manifestation of systemic sarcoidosis, with a propensity for middle-agedwomen. Often discovered only at autopsy, rates of neurologic involvement (5%-10%) reported in the literature underscore a lack of sensitivity and specificity in current diagnostic methods. PATIENT CONCERNS: Herein, we describe a 53-year-old woman who presented with gait imbalance and distal extremity muscular weakness. She was known to harbor a brain mass (4 years in duration) that was monitored and recently seemed to enlarge...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29135404/-bilateral-total-lung-lavage-in-a-patient-with-pulmonary-alveolar-proteinosis
#9
Müge Erbay, Yılmaz Bülbül, Funda Öztuna, Mehmet Kılıç, Neslihan Özçelik, Şafak Ersöz
Pulmonary alveolar proteinosis (PAP) is a rare pulmonary disease characterised by alveolar accumulation of surfactant composed of proteins and lipids. Three main categories of PAP have been defined depending on the aetiology: primer/idiopathic, neonatal/congenital, secondary and exogenous/environmental exposure. Radiologically diffuse ground glass opacities, interlobular and intralobular septal thickening is seen. Although open lung biopsy is accepted as the gold standard in diagnosis, it can be diagnosed by showing bronchoalveolar lavage (BAL) fluid with a milky appearance and periodic acid-schiff (PAS) positive globules in biopsy with clinical and radiological findings...
September 2017: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/29124891/the-diagnostic-value-of-tissue-button-technique-for-specimen-accusation-during-endobronchial-ultrasound-guided-transbronchial-fine-needle-aspiration
#10
Oren Fruchter, Anna Breslavsky, Tatyana Brozgol, Anna Grossman, Kessi Mikhailova, Alexey Bugayov, Kassa Shimelis, Hananya Vaknine, Oleg Sukmanov
INTRODUCTION: The quality of tissue acquisition during Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a major determinant of the diagnostic yield of the procedure. In the tissue button (TB ) technique the retrieved cellular specimen is fixed in ethanol and subsequently scraped from slide using surgical blade into formaldehyde and processed like ordinary tissue biopsy thus potentially increasing its diagnostic value. OBJECTIVES: To retrospectively evaluate the diagnostic yield of a TB technique in patients undergoing EBUS-TBNA for various malignant and benign conditions...
November 10, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29119620/identification-of-oestrogen-progesterone-receptor-and-human-epidermal-growth-factor-receptor-2-expression-in-mediastinal-metastases-of-breast-cancer-obtained-by-endobronchial-ultrasound-guided-transbronchial-needle-aspiration
#11
P Serra, J Sanz-Santos, E Castellà, B Cirauqui, F Andreo, M Llatjós, M Avila, M Margelí, L Serrano, C Centeno, V Quiroga, M Torky, J Ruiz-Manzano
BACKGROUND: In breast cancer patients, the expression statuses of oestrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) are crucial in the choice of treatment. Receptor expression in metastatic lesions can differ from the primary tumour. The aim of our study was to analyse the utility of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) to obtain samples allowing the identification of ER, PR and HER2 expression in patients with mediastinal metastases of breast cancer...
November 9, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29114418/stop-being-so-sensitive-an-exceptionally-rare-report-of-ustekinumab-induced-sub-acute-hypersensitivity-pneumonitis
#12
Azka Ali, Jason Chertoff, Christopher Harden, Dara Wakefield, James Wynne
Hypersensitivity pneumonitis (HSP) is a rare syndrome characterised by granulomatous inflammatory lung disease due to repeated sensitisation from a specific antigen. We present the case of a 61-year old male veteran with a history of nodular eczema who presented with 2 weeks of progressive dyspnoea on exertion and pleuritic chest pain. The patient was started on ustekinumab 5 weeks prior to presentation. Initial workup revealed ground-glass opacities on computed tomography (CT) scan of the chest. Cardiac workup was unrevealing with a normal myocardial perfusion stress test...
October 2017: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/29110850/nanoparticle-targeted-folate-receptor-1-enhanced-photodynamic-therapy-for-lung-cancer
#13
Tatsuya Kato, Cheng S Jin, Hideki Ujiie, Daiyoon Lee, Kosuke Fujino, Hironobu Wada, Hsin-Pei Hu, Robert A Weersink, Juan Chen, Mitsuhito Kaji, Kichizo Kaga, Yoshiro Matsui, Brian C Wilson, Gang Zheng, Kazuhiro Yasufuku
OBJECTIVE: Despite modest improvements, the prognosis of lung cancer patients has still remained poor and new treatment are urgently needed. Photodynamic therapy (PDT), the use of light-activated compounds (photosensitizers) is a treatment option but its use has been restricted to central airway lesions. Here, we report the use of novel porphyrin-lipid nanoparticles (porphysomes) targeted to folate receptor 1 (FOLR1) to enhance the efficacy and specificity of PDT that may translate into a minimally-invasive intervention for peripheral lung cancer and metastatic lymph nodes of advanced lung cancer...
November 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29107084/evidence-for-m2-macrophages-in-granulomas-from-pulmonary-sarcoidosis-a-new-aspect-of-macrophage-heterogeneity
#14
Masoud Shamaei, Esmaeil Mortaz, Mihan Pourabdollah, Johan Garssen, Payam Tabarsi, Aliakbar Velayati, Ian M Adcock
BACKGROUND: Sarcoidosis is a granulomatous disease of unknown etiology. Macrophages play a key role in granuloma formation with the T cells, having a significant impact on macrophage polarization (M1 and M2) and the cellular composition of the granuloma. This study evaluates macrophage polarization in granulomas in pulmonary sarcoidosis. MATERIALS AND METHODS: Tissue specimens from the Department of Pathology biobank at the Masih Daneshvari Hospital were obtained...
October 26, 2017: Human Immunology
https://www.readbyqxmd.com/read/29105361/a-multicenter-study-on-the-safety-and-efficacy-of-different-methods-for-obtaining-transbronchial-lung-cryobiopsy-in-diffuse-lung-diseases
#15
Sahajal Dhooria, Ravindra Mehta, Arjun Srinivasan, Karan Madan, Inderpaul Singh Sehgal, Vallandramam Pattabhiraman, Pavan Yadav, Mahadevan Sivaramakrishnan, Anant Mohan, Amanjit Bal, Mandeep Garg, Ritesh Agarwal
INTRODUCTION: Most data on transbronchial lung cryobiopsy (TBLC) are from single centers, with little evidence on the outcome of different methods for performing TBLC. OBJECTIVE: To report the diagnostic yield and safety of TBLC with different procedural techniques. METHODS: Retrospective multicenter study of subjects who underwent TBLC for the diagnosis of diffuse parenchymal lung diseases (DPLDs). The procedure was performed using various methods: flexible or rigid bronchoscopy, with or without the use of fluoroscopy or occlusion balloon...
November 4, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29105350/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-with-the-flexible-19-gauge-needle
#16
Rocco Trisolini, Filippo Natali, Marco Ferrari, Vanina Livi, Daniela Paioli, Micaela Romagnoli, Alessandra Cancellieri
INTRODUCTION AND OBJECTIVES: Endosonography has become standard of care in the diagnostic work-up of mediastinal lymphadenopathy and peribronchial lung lesions, but its success rate in some specific settings/conditions may be hampered by limited needle flexibility and size. We report on our initial experience with the 19G Flex needle, characterized by larger size and greater flexibility as compared with the currently available cytology needles. METHODS: Retrospective review of prospectively collected data on the first 13 consecutive patients submitted to endosonography with the 19G Flex needle...
November 4, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29104113/primary-mammary-analogue-secretory-carcinoma-of-the-lung-a-case-report
#17
Tao Huang, Jonathan B McHugh, Gerald J Berry, Jeffrey L Myers
Mammary analogue secretory carcinoma (MASC) is a recently discovered salivary gland tumor described mostly in the major salivary glands and occasionally in the skin. We report a primary endobronchial tumor with histology, immunophenotype, and ETV6 rearrangement characteristic of MASC in a 62-year-old woman. The diagnosis was initially made on a transbronchial biopsy with FISH confirmation of ETV6 rearrangement. The patient underwent lobectomy demonstrating a large endobronchial mass. To our knowledge, this is the first report of MASC arising as a primary pulmonary tumor...
November 2, 2017: Human Pathology
https://www.readbyqxmd.com/read/29099004/isolated-pulmonary-involvement-in-erdheim-chester-disease
#18
Enambir Singh Josan, Jason W Green, Syed Imran M Zaidi, Jayantilal B Mehta
Erdheim-Chester disease is a rare non-Langerhans cell histiocytic disorder. It is primarily a disease of the long bones. Pulmonary involvement in systemic disease is detected in about half the reported cases. Isolated lung involvement is extremely rare with no clear recommendations for treatment. A 52-year-old caucasian male was evaluated for 1.9 cm × 1.6 cm spiculated nodule in the right upper lobe. Pulmonary function testing and bronchoscopy with endobronchial ultrasound, transbronchial biopsy, and microbiology were inconclusive...
November 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29098999/tracheobronchial-puncture-site-nodular-reaction-tpnr-following-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-ebus-tbna-systematic-review-of-case-reports
#19
REVIEW
Karan Madan, Pavan Tiwari, Sudheer Arava, Vijay Hadda, Anant Mohan, Randeep Guleria
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive and efficacious diagnostic modality for lung cancer staging and evaluation of undiagnosed mediastinal lymphadenopathy. Procedure-related complications are uncommon. We herein report an infrequently described phenomenon following EBUS-TBNA in which two patients developed nodular granulation tissue at the tracheobronchial puncture site. On systematic review, we found description of such phenomena by terminologies such as endobronchial inflammatory polyp, granuloma, and endobronchial mass...
November 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29097432/endoscopic-ultrasound-fine-needle-aspiration-by-experienced-pulmonologists-a-cusum-analysis
#20
Paul Leong, Sheetal Deshpande, Louis B Irving, Philip G Bardin, Michael W Farmer, Barton R Jennings, Daniel P Steinfort
Endobronchial ultrasound transbronchial needle aspiration (EBUS TBNA) is an established, minimally invasive way to sample intrathoracic abnormalities. The EBUS scope can be passed into the oesophagus to perform endoscopic ultrasound with bronchoscope-guided fine-needle aspiration (EUS-B-FNA). In cases of suspected lung cancer, a combination of the two techniques is now recommended by consensus guidelines. EBUS TBNA is usually performed by pulmonologists; however, the learning curve for EUS-B-FNA, which may be performed during the same procedure, has not been described...
November 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
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