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https://www.readbyqxmd.com/read/29771778/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-using-19-g-needle-for-sarcoidosis
#1
Akshu Balwan
BACKGROUND: Flexible bronchoscopy with endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (TBNA) is increasingly being used to obtain pathology specimens for diagnosis of sarcoidosis. There is wide variation in reported diagnostic yield in literature. New TBNA needles are available in the market but data are lacking about their diagnostic yield especially for sarcoidosis. This study reports the diagnostic yield of bronchoscopy with EBUS-TBNA using ViziShot FLEX 19-G needle in a series of patients with suspected sarcoidosis...
May 16, 2018: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/29771776/comparison-of-sample-adequacy-and-diagnostic-yield-of-19-and-22-g-ebus-tbna-needles
#2
Udit Chaddha, Reza Ronaghi, Waafa Elatre, Ching-Fei Chang, Ramyar Mahdavi
BACKGROUND: The 2016 CHEST consensus guidelines recommend use of either 21- or 22-G needles for endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). We decided to prospectively compare sample adequacy and diagnostic yield of the 19-G with the 22-G EBUS needle, hypothesizing that a larger gauge difference might magnify the differences between 2 needle sizes. METHODS: Twenty-seven patients undergoing EBUS-TBNA at our institution were evaluated...
May 16, 2018: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/29771773/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-with-a-19-g-needle-device
#3
Alain Tremblay, Seamus McFadden, Martina Bonifazi, Valentina Luzzi, Samuel V Kemp, Stefano Gasparini, Alex Chee, Paul MacEachern, Elaine Dumoulin, Christopher A Hergott, Pallav L Shah
BACKGROUND: Endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration is a well-established first-line minimally invasive modality for mediastinal lymph node sampling. Although results are excellent overall, the technique underperforms in certain situations. We aimed to describe our results using a new 19-G EBUS-guided transbronchial needle aspiration device to determine safety and feasibility of this approach. METHODS: We completed a retrospective chart review of all cases performed to the time of data analysis at each of 3 study sites...
May 16, 2018: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/29768518/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-ebus-tbna-in-diagnosis-of-mediastinal-lesions
#4
Ricardo Sales Dos Santos, Marcia Jacomelli, Juliana Pereira Franceschini, Iunis Suzuki, Altair da Silva Costa, Christina Shiang, Addy Lidvina Mejia Palomino
OBJECTIVE: To describe the results of endobronchial ultrasound-guided transbronchial needle aspiration in making diagnosis of mediastinal injuries associated to different causes. METHODS: A retrospective cross-sectional study of patients submitted to Endobronchial ultrasound-guided transbronchial needle aspiration at a private organization, between June 2013 and October 2016. All cases referred for collection of lymph nodes or peritracheal/peribronchial masses by endobronchial ultrasound-guided transbronchial needle aspiration, and evaluated through tomography or PET-CT were included...
May 14, 2018: Einstein
https://www.readbyqxmd.com/read/29768382/transbronchial-drainage-using-endobronchial-ultrasonography-with-guide-sheath-for-lung-abscess-a-case-report
#5
Daizo Yaguchi, Motoshi Ichikawa, Noriko Inoue, Daisuke Kobayashi, Masato Shizu, Naoyuki Imai
RATIONALE: Lung abscess was previously treated surgically, but is now mainly treated with antibiotics and ideally with direct drainage, although postural drainage canalso be used. PATIENT CONCERNS: A chest abnormal shadow was detected in an 82-year-old man and he was referred to our department in November 2017. On chest computed tomography (CT), a low-density mass shadow was present in the left S8 segment. Lung abscess and lung cancer were considered as differential diagnoses, and treatment with sulbactam sodium/ampicillin sodium (SBT/ABPC) was first initiated for lung abscess...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29764751/needle-wash-solution-cultures-following-ebus-tbna-with-or-without-endobronchial-intubation
#6
Daisuke Minami, Nagio Takigawa, Masahide Oki, Hideo Saka, Takuo Shibayama, Katsuyuki Kiura
BACKGROUND: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive procedure with a high diagnostic yield in lesions adjacent to the airways. However, complications associated with EBUS-TBNA, such as mediastinitis, have recently been reported. Oral bacteria contamination in punctured lymph nodes can cause severe infections. In the current study, we investigated whether endobronchial intubation using EBUS-TBNA can prevent oral bacterial contamination of punctured lymph nodes...
May 10, 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29764379/identification-of-usual-interstitial-pneumonia-pattern-using-rna-seq-and-machine-learning-challenges-and-solutions
#7
Yoonha Choi, Tiffany Ting Liu, Daniel G Pankratz, Thomas V Colby, Neil M Barth, David A Lynch, P Sean Walsh, Ganesh Raghu, Giulia C Kennedy, Jing Huang
BACKGROUND: We developed a classifier using RNA sequencing data that identifies the usual interstitial pneumonia (UIP) pattern for the diagnosis of idiopathic pulmonary fibrosis. We addressed significant challenges, including limited sample size, biological and technical sample heterogeneity, and reagent and assay batch effects. RESULTS: We identified inter- and intra-patient heterogeneity, particularly within the non-UIP group. The models classified UIP on transbronchial biopsy samples with a receiver-operating characteristic area under the curve of ~ 0...
May 9, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29755101/-outcome-of-surgical-treatment-of-locally-advanced-lung-cancer-after-induction-chemoradiotherapy
#8
Masayuki Tanahashi, Haruhiro Yukiue, Eriko Suzuki, Naoko Yoshii, Shinsuke Kitazawa, Yasunori Kaminuma, Hiroshi Niwa
OBJECTIVE: The outcome of surgical treatment of non-small-cell lung cancer after induction chemoradiotherapy was investigated. SUBJECTS: The subjects were 74 patients with non-small-cell lung cancer who received induction chemoradiotherapy( ICRT) between 1998 and 2016. ICRT was administered to pT3 lung cancer invading the chest wall(20 patients), pT4 lung cancer invading the adjacent organ(22 patients), and cN2 lung cancer(32 patients). cN2 was confirmed by mediastinoscopy(13 patients) and endobronchial ultrasound-guided transbronchial needle aspiration(EBUS-TBNA)(19 patients)...
April 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29755082/-pulmonary-pleomorphic-carcinoma-relapsed-after-surgery-surviving-long-term-by-chemotherapy-and-nivolumab
#9
Osamu Kawamata, Toshihiro Murata, Masashi Uda
A 60'-year-old man was referred to our hospital because of nodular shadow found at mass screening. We diagnosed the tumor as non-small cell lung cancer by transbronchial biopsy. Chest computed tomography showed a tumor shadow of 3 cm in diameter with cavity. Right middle lobectomy was performed and the pathological diagnosis was pleomorphic carcinoma of the lung. The tumor recurrence was found at 10 months after surgery, and was treated with cisplatin, docetaxel plus bevacizumab for 6 cycles. A complete remission was achieved, but regrowth at 5 months after chemotherapy was noted...
May 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29748308/fibroblast-growth-factor-23-and-klotho-contribute-to-airway-inflammation
#10
Stefanie Krick, Alexander Grabner, Nathalie Baumlin, Christopher Yanucil, Scott Helton, Astrid Grosche, Juliette Sailland, Patrick Geraghty, Liliana Viera, Derek W Russell, J Michael Wells, Xin Xu, Amit Gaggar, Jarrod Barnes, Gwendalyn D King, Michael Campos, Christian Faul, Matthias Salathe
Circulating levels of fibroblast growth factor (FGF) 23 are associated with systemic inflammation and increased mortality in chronic kidney disease. α-klotho, a co-receptor for FGF23, is downregulated in chronic obstructive pulmonary disease (COPD). However, whether FGF23 and klotho-mediated FGFR activation delineates a pathophysiologic mechanism in COPD remains unclear. We hypothesized that FGF23 can potentiate airway inflammation via klotho independent FGFR4 activation. FGF23 and its effect were studied using plasma and transbronchial biopsies from COPD and control patients and primary human bronchial epithelial cells isolated from COPD patients as well as a murine COPD model...
May 10, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29732194/imaging-techniques-for-minimally-invasive-thoracic-surgery-korea-university-guro-hospital-experiences
#11
REVIEW
Kook Nam Han, Hyun Koo Kim
In this paper, we described our clinical experiences with respect to image-guided thoracic surgery, including procedures involving percutaneous injection of fluorescent dye, radiotracers, and hook wires, guided by preoperative computed tomography (CT); and transbronchial injection of fluorescent dye by using electromagnetic navigational bronchoscope technology. Our recent experience with the intravenous systemic injection of fluorescent dye for the intraoperative detection of pulmonary lesions and intersegmental planes are also described in this review...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29730680/differentiating-metastatic-lymph-nodes-in-lung-cancer-patients-based-on-endobronchial-ultrasonography-features
#12
Ching-Kai Lin, Lih-Yu Chang, Kai-Lun Yu, Yueh-Feng Wen, Hung-Jen Fan, Chao-Chi Ho
AIM: The aim of this study was to identify easy and relatively effective ultrasound criteria for metastatic mediastinal lymph node prediction. MATERIALS AND METHODS: A retrospective chart review of patients who underwent endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) from March 2014 to September 2016 was performed. We used the following EBUS sonographic features for metastatic lymph node prediction: 1) length of the short axis, 2) shape, 3) margin, 4) echogenicity, 5) central hilar structure, and 6) coagulation necrosis sign...
May 2, 2018: Medical Ultrasonography
https://www.readbyqxmd.com/read/29721074/polyamine-targeting-gefitinib-prodrug-and-its-near-infrared-fluorescent-theranostic-derivative-for-monitoring-drug-delivery-and-lung-cancer-therapy
#13
Xinyu Song, Xiaoyue Han, Fabiao Yu, Xiaoyu Zhang, Lingxin Chen, Changjun Lv
The therapy of non-small-cell lung cancer (NSCLC) is challenging because of poor prognosis. There are urgent demands for targeting anti-tumor drugs with reliable efficacy and clear pharmacokinetics. Methods : We designed and synthesized an active tumor-targeting prodrug for the precision therapy of NSCLC. The prodrug polyamine analog Gefitinib (PPG) was derived from the conjugation between a tumor-targeting ligand polyamine analog (PA) and an epidermal growth factor receptor tyrosine kinase inhibitor Gefitinib via a cleavable disulfide linker...
2018: Theranostics
https://www.readbyqxmd.com/read/29719810/delayed-pneumothorax-a-potential-complication-of-transbronchial-lung-biopsy
#14
Naureen Narula, Faraz Siddiqui, Abdul Hasan Siddiqui, Wai C Man, Michel Chalhoub
The purpose of this article is to report a case of secondary tension pneumothorax presenting seven weeks post Transbronchial Lung biopsy. A 62 year old male with a known history of germ cell tumor was found to have a left-sided pneumothorax which later complicated to a tension pneumothorax.To the best of our knowledge this is the second case being reported for a delayed pneumothorax post a Transbronchial Lung Biopsy .The purpose of this case report is to create awareness among physicians to consider this diagnosis even at a later stage and the importance of patient education regarding the signs and symptoms of pneumothorax...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29719195/sarcoidosis-a-state-of-the-art-review-from-the-thoracic-society-of-australia-and-new-zealand
#15
Hasib Ahmadzai, Shuying Huang, Chris Steinfort, James Markos, Roger Ka Allen, Denis Wakefield, Margaret Wilsher, Paul S Thomas
Sarcoidosis is a systemic disease of unknown aetiology, characterised by non-caseating granulomatous inflammation. It most commonly manifests in the lungs and intrathoracic lymph nodes but can affect any organ. This summary of an educational resource provided by the Thoracic Society of Australia and New Zealand outlines the current understanding of sarcoidosis and highlights the need for further research. Our knowledge of the aetiology and immunopathogenesis of sarcoidosis remains incomplete. The enigma of sarcoidosis lies in its immunological paradox of type 1 T helper cell-dominated local inflammation co-existing with T regulatory-induced peripheral anergy...
May 7, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29709938/a-case-of-pulmonary-alveolar-proteinosis-with-ulcerative-colitis
#16
Noriho Sakamoto, Shota Nakashima, Hiroshi Ishimoto, Tomoyuki Kakugawa, Atsuko Hara, Hirokazu Yura, Takuto Miyamura, Seiko Nakamichi, Yasushi Obase, Yuji Ishimatsu, Hiroshi Mukae
A 65-year-old Japanese man was referred to our hospital for the further assessment of cough and dyspnea. He had a history of ulcerative colitis for which he was receiving treatment. Chest computed tomography showed a crazy-paving pattern. His bronchoalveolar lavage fluid had a milky appearance, and a transbronchial lung biopsy specimen revealed acellular periodic acid-Schiff stain-positive bodies. The serum anti-GM-CSF antibody titer was elevated. The diagnosis was autoimmune pulmonary alveolar proteinosis (PAP)...
April 27, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29708957/transbronchial-lung-cryobiopsy-guided-by-endobronchial-ultrasound-radial-miniprobe-in-interstitial-lung-diseases-preliminary-results-of-a-prospective-study
#17
Maciej Gnass, Anna Filarecka, Juliusz Pankowski, Jerzy Soja, António Bugalho, Artur Szlubowski
No abstract text is available yet for this article.
April 30, 2018: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29707351/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-and-cervical-mediastinoscopy-for-mediastinal-staging-of-non-small-cell-lung-cancer-a-retrospective-comparison-study
#18
Rong Zhang, Yuxiang Ma, Guoliang Xu, Xiaoyan Gao, Guangyu Luo, Qingguang Lin, Yunpeng Yang, Xin Wang, Li Zhang
Background: Invasive mediastinal lymph node staging is essential to resectable non-small cell lung cancer (NSCLC) patients. This retrospective study aimed to compare the diagnostic yield of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) against cervical mediastinoscopy (CMS) in radiologically enlarged mediastinal lymph nodes. Methods: Retrospective data were collected from January 2009 to March 2016. Suspected lung cancer patients with enlarged mediastinal lymph nodes (short axis ≥10 mm), underwent EBUS-TBNA or CMS for invasive mediastinal staging were enrolled...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29703650/lung-abscess-following-bronchoscopy-due-to-multidrug-resistant-capnocytophaga-sputigena-adjacent-to-lung-cancer-with-high-pd-l1-expression
#19
Yohei Migiyama, Moriyasu Anai, Kosuke Kashiwabara, Yusuke Tomita, Sho Saeki, Kazuyoshi Nakamura, Shinichiro Okamoto, Hidenori Ichiyasu, Kazuhiko Fujii, Hirotsugu Kohrogi
Lung abscess following flexible bronchoscopy is a rare and sometimes fatal iatrogenic complication. Here, we report the first case of a lung abscess caused by multidrug-resistant Capnocytophaga sputigena following bronchoscopy. A 67-year-old man underwent bronchoscopy to evaluate a lung mass. Seven days after transbronchial lung biopsy, he presented with an abscess formation in a lung mass. Empirical antibiotic therapy, including with garenoxacin, ampicillin/sulbactam, clindamycin and cefepime, was ineffective...
April 24, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29697082/vintage-meets-contemporary-use-of-rigid-tbna-in-the-era-of-real-time-imaging-first-report-from-india
#20
Ajmal Khan, Alok Nath, Hira Lal, Narendra Krishnani, Aarti Agarwal
In the modern era, real-time imaging-guided transbronchial needle aspiration (TBNA) has completely replaced the traditional surgical approaches to sample the mediastinal lesions for diagnosis and cancer staging. However, there is a limited role of these innovations in the presence of critical airway narrowing due to a further decrease in cross-sectional area of the airway proportionate to the outer diameters of the scope. Rigid TBNA with airway control by rigid bronchoscopy is one alternative which can be used for mediastinal sampling when modern technique is impracticable...
May 2018: Lung India: Official Organ of Indian Chest Society
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