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https://www.readbyqxmd.com/read/28446970/the-role-of-endobronchial-ultrasound-versus-mediastinoscopy-for-non-small-cell-lung-cancer
#1
REVIEW
Katarzyna Czarnecka-Kujawa, Kazuhiro Yasufuku
This review provides an update on the current role of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and mediastinoscopy (Med) in assessment of patients with non-small cell lung cancer (NSCLC). Invasive mediastinal lymph node (LN) staging is the major application for both of these techniques. Up until recently, Med was the gold standard for invasive mediastinal LN staging in NSCLC. However, EBUS-TBNA has shown to be equivalent, and in some studies better than Med for invasive staging of lung cancer...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28446601/diffuse-parenchymal-lung-disease
#2
REVIEW
Sara Tomassetti, Claudia Ravaglia, Venerino Poletti
Between September 2015 and August 2016 there were >1500 publications in the field of diffuse parenchymal lung diseases (DPLDs). For the Clinical Year in Review session at the European Respiratory Society Congress that was held in London, UK, in September 2016, we selected only five articles. This selection, made from the enormous number of published papers, does not include all the relevant studies that will significantly impact our knowledge in the field of DPLDs in the near future. This review article provides our personal view on the following topics: early diagnosis of idiopathic pulmonary fibrosis, current knowledge on the multidisciplinary team diagnosis of DPLDs and the diagnostic role of transbronchial cryobiopsy in this diagnostic setting, insights on the new entity of interstitial pneumonia with autoimmune features, and new therapeutic approaches for scleroderma-related interstitial lung disease...
June 30, 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/28440531/initial-polish-experience-of-flexible-19-gauge-endobronchial-ultrasound-guided-transbronchial-needle-aspiration
#3
Maciej Gnass, Joanna Sola, Anna Filarecka, Stanisław Orzechowski, Piotr Kocoń, Monika Pasieka-Lis, Juliusz Pankowski, Lucyna Rudnicka, Jerzy Soja, Artur Szlubowski
INTRODUCTION: EBUS is a well established minimally invasive diagnostic tool for mediastinal and hilar lymphadenopathy. The novel ViziShot Flex 19G needle (Olympus Respiratory America, Redmond, WA, USA) was introduced in 2015 in order to improve loaded scope flexion and to obtain larger tissue samples for analysis. The aims of this study were to assess diagnostic yield of Flex 19G needles and to present endoscopist's feedback about the endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA)...
2017: Advances in Respiratory Medicine
https://www.readbyqxmd.com/read/28438882/rebiopsy-of-histological-samples-in-pretreated-non-small-cell-lung-cancer-comparison-among-rebiopsy-procedures
#4
Akito Hata, Nobuyuki Katakami, Shigeki Nanjo, Chiyuki Okuda, Reiko Kaji, Yukihiro Imai
AIM: The aim of the present study was to compare successful rate, failure reasons, and complications among procedures of histological rebiopsy. PATIENTS AND METHODS: We retrospectively reviewed medical records of histologically rebiopsied cases with non-small cell lung cancer. RESULTS: One hundred and eleven histological rebiopsies were performed in: 86 (77%) lung; 11 (10%) lymph node; 5 (5%) pleura; 4 (4%) liver; 2 (2%) muscle; 2 (2%) adrenal gland; and 1 (1%) rib...
May 2017: In Vivo
https://www.readbyqxmd.com/read/28436174/endobronchial-and-transbronchial-biopsy-experience-a-united-kingdom-survey
#5
REVIEW
Janet Fallon, Andrew R L Medford
BACKGROUND: Trainees are performing fewer bronchoscopies as a result of the increased use of endobronchial ultrasound-guided transbronchial needle aspiration. Workforce planning and changes in trainee working patterns may also have compounded this situation. We investigated current trends in endobronchial biopsy (EBB) and transbronchial biopsy (TBB) training and competency in respiratory trainees and consultants across the United Kingdom. METHODS: We performed a national survey and received 131 online responses from 58 consultants and 73 registrars across 13 United Kingdom deaneries...
April 24, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28436173/relationship-between-endobronchial-ultrasound-guided-ebus-transbronchial-needle-aspiration-utility-and-computed-tomography-staging-node-size-at-ebus-and-positron-emission-tomography-scan-node-standard-uptake-values-a-retrospective-analysis
#6
Clare Marchand, Andrew R L Medford
BACKGROUND: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) diagnoses and stages mediastinal lymph node pathology. This retrospective study determined the relationship between EBUS-TBNA utility and non-small cell lung cancer (NSCLC) stage, lymph node size, and positron emission tomography (PET) standard uptake values (SUV), and the utility of neck ultrasound in bulky mediastinal disease. METHODS: Data of 284 consecutive patients who had undergone EBUS-TBNA was collected...
April 24, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28423346/endobronchial-ultrasound-transbronchial-biopsy-with-guide-sheath-for-the-diagnosis-of-solitary-pulmonary-nodules
#7
Chun-Hua Xu, Qi Yuan, Li-Ke Yu, Wei Wang, Yong Lin
The aim of this study was to assess the usefulness of endobronchial ultrasound transbronchial biopsy with guide-sheath (EBUS-GS-TBB) for the diagnosis of solitary pulmonary nodules (SPNs). One hundred and eighty patients, who were diagnosed with SPNs and underwent an endobronchial ultrasound procedure. The diagnostic yield, safety and the associated factors were analyzed. Mean EBUS-GS procedure time was 14±8 min. The average number of biopsy specimens obtained in each SPNs was 5±1.2. One hundred and thirty-four SPNs were diagnosed by EBUS-GS-TBB and the diagnostic rate was 74...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28410706/conventional-tbna-experience-over-a-10-year-period-diagnostic-yield-and-associated-limitations-in-a-tertiary-care-government-set-up
#8
Varinder Saini, Kranti Garg, Uma Handa, Ritisha Bhatt
INTRODUCTION: It is challenging for pulmonologists to sample mediastinal lymph nodes or some endobronchial lesions because of safety concerns. C-TBNA (conventional transbronchial needle aspiration) is a procedure to sample such sites, but is underutilized. We present a retrospective review of patients subjected to C-TBNA through fibre-optic bronchoscopy over a 10-year period. MATERIALS AND METHODS: Year-wise statistics of C-TBNA was reviewed and results were analyzed with regard to sampling sites and type of intraluminal lesions encountered, diagnosis made and their correlation with sampling sites, sex and age...
April 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28399377/transbronchial-lung-cryobiopsy-and-video-assisted-thoracoscopic-lung-biopsy-in-the-diagnosis-of-diffuse-parenchymal-lung-disease-a-meta-analysis-of-diagnostic-test-accuracy
#9
Imran H Iftikhar, Lana Alghothani, Alejandro Sardi, David Berkowitz, Ali I Musani
BACKGROUND: Transbronchial lung cryobiopsy (TBLC) is increasingly being used for the assessment of diffuse pulmonary lung diseases (DPLD). Several studies have shown larger biopsy samples and higher yields compared to conventional transbronchial biopsies. However, the higher risk of bleeding and other complications has raised concerns for widespread use of this modality. OBJECTIVE: To study the diagnostic accuracy and safety profile of TBLC and compare with video assisted thoracoscopic (VATS), by reviewing available evidence from the literature...
April 11, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28397462/the-diagnostic-value-of-carcinoembryonic-antigen-and-squamous-cell-carcinoma-antigen-in-lung-adenosquamous-carcinoma
#10
Xiangyu Jin, Xiaoling Xu, Haimiao Xu, Lei Lv, Hongyang Lu
BACKGROUND: Lung adenosquamous carcinoma (ASC) is a rare malignant tumor with an adenocarcinoma and a squamous cell carcinoma component and associated with a lower 5-year survival rate than lung squamous cell carcinoma and lung adenocarcinoma. Surgical specimen histology revealed the inadequacy of conventional transbronchial needle aspiration samples in the diagnosis of lung ASC. Most lung ASC patients are not suitable to receive surgery, and it is difficult to diagnose ASC. This study is to explore the possibility of using serum carcinoembryonic antigen (CEA) and squamous cell carcinoma antigen (SCC) as a supplementary diagnostic test for ASC...
April 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28393574/transbronchial-biopsies-safely-diagnose-amyloid-lung-disease
#11
Praveen Govender, Colleen M Keyes, Elizabeth A Hankinson, Carl J O'Hara, Vaishali Sanchorawala, John L Berk
BACKGROUND: Autopsy identifies lung involvement in 58-92% of patients with the most prevalent forms of systemic amyloidoses. In the absence of lung biopsies, amyloid lung disease often goes unrecognized. Report of a death following transbronchial biopsies in a patient with systemic amyloidosis cautioned against the procedure in this patient cohort. We reviewed our experience with transbronchial biopsies in patients with amyloidosis to determine the safety and utility of bronchoscopic lung biopsies...
April 10, 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28393007/interstitial-lung-disease-pattern-turned-out-to-be-a-predominantly-lepidic-lung-adenocarcinoma
#12
Irena Hammen
We report a case of a 46-year-old woman without any medical history who presented to our Respiratory Department with exertional dyspnoea for the last 6 weeks associated with non-productive cough. Chest radiography showed bilateral diffuse interstitial opacity. Bronchoalveolar lavage and transbronchial biopsies performed during flexible bronchoscopy as a step in the diagnostic workup of idiopathic interstitial pneumonia showed cells of pulmonary adenocarcinoma.
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28393006/small-cell-lung-cancer-transformation-during-immunotherapy-with-nivolumab-a-case-report
#13
Takuma Imakita, Kohei Fujita, Osamu Kanai, Tsuyoshi Terashima, Tadashi Mio
We report a rare case of transformation of non-small cell lung cancer (NSCLC) to small cell lung cancer (SCLC), without epidermal growth factor receptor (EGFR) gene mutation, during immunotherapy treatment with nivolumab. A 75-year-old man was referred to our hospital following the observation of a 64 mm mass in a chest computed tomography (CT) scan. A transbronchial biopsy of the mass identified the pathological presence of poorly differentiated NSCLC, with no histological signs of SCLC. No mutations were identified in the EGFR gene...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28385164/diffuse-idiopathic-pulmonary-neuroendocrine-cell-hyperplasia-diagnosed-by-transbronchial-lung-cryobiopsy-a-case-report
#14
R Sauer, S Griff, A Blau, A Franke, T Mairinger, C Grah
BACKGROUND: Micronodular lesions are common findings in lung imaging. As an important differential diagnosis, we describe a case of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia; it is notable that the diagnosis of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia is often delayed. This case provides supporting evidence to establish lung biopsy by cryotechnique as the option of first choice when considering a diagnostic strategy for micronodular lung lesions...
April 7, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28381749/systemic-air-embolism-following-diagnostic-bronchoscopy
#15
Taisuke Tsuji, Shoko Sonobe, Taro Koba, Toshiya Maekura, Naoko Takeuchi, Kazunobu Tachibana
A 51-year-old man was admitted to have a nodule evaluated using chest computed tomography (CT). Shortly after curetting and transbronchial biopsies via bronchoscopy, hypotension, bradycardia, unconsciousness, and left hemiplegia appeared and resolved within one hour. Head CT showed cerebral air embolism. The following day, lower left quadrant pain developed. Pneumatosis intestinalis on abdominal CT and elevation of creatine kinase and troponin T levels indicated air embolism in the mesenteric and coronary arteries...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28372894/the-additional-role-of-xpert-mtb-rif-in-the-diagnosis-of-intrathoracic-tuberculous-lymphadenitis
#16
Jinwoo Lee, Sun Mi Choi, Chang-Hoon Lee, Sang-Min Lee, Jae-Joon Yim, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Young Sik Park
BACKGROUND: Diagnosis of intrathoracic tuberculosis (TB) lymphadenitis remains a challenge because of difficulties in obtaining adequate tissue and the lack of a sensitive test. Recently, Xpert MTB/RIF assay is being used for rapid diagnosis of pulmonary TB, but it has not yet been widely validated in intrathoracic TB lymphadenitis. The aim of this study was to assess the additional role of Xpert MTB/RIF in diagnosing intrathoracic TB lymphadenitis using endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) specimen...
March 31, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28365626/update-in-diagnosis-and-management-of-interstitial-lung-disease%C3%A2
#17
Theresia A Mikolasch, Helen S Garthwaite, Joanna C Porter
The field of interstitial lung disease (ILD) has undergone significant evolution in recent years, with an increasing incidence and more complex, ever expanding disease classification. In their most severe forms, these diseases lead to progressive loss of lung function, respiratory failure and eventually death. Despite notable advances, progress has been challenged by a poor understanding of pathological mechanisms and patient heterogeneity, including variable progression. The diagnostic pathway is thus being continually refined, with the introduction of tools such as transbronchial cryo lung biopsy and a move towards genetically aided, precision medicine...
April 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28362535/diffuse-large-b-cell-lymphoma-presenting-as-diffuse-bilateral-ground-glass-opacities-and-diagnosed-on-transbronchial-lung-biopsy
#18
Hanine Inaty, Cesar Artiles, Ruchi Yadav, Puneet Garcha, Sanjay Mukhopadhyay, Debasis Sahoo
No abstract text is available yet for this article.
April 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28361002/a-case-of-lung-abscess-successfully-treated-by-transbronchial-drainage-using-a-guide-sheath
#19
Hiroki Izumi, Masahiro Kodani, Shingo Matsumoto, Yuji Kawasaki, Tadashi Igishi, Eiji Shimizu
A 51-year-old man was diagnosed with colon cancer in September 2011, and a solitary pulmonary nodule was detected by computed tomography (CT) scan. We performed a transbronchial biopsy with endobronchial ultrasonography using a guide sheath (GS) and diagnosed lung metastasis of colon cancer. The patient experienced remittent fever after the biopsy in spite of intravenous antibiotic therapies. Moreover, his CT scan showed a large lung abscess at the biopsy site. We performed transbronchial drainage using a GS as salvage therapy...
May 2017: Respirology Case Reports
https://www.readbyqxmd.com/read/28355600/usefulness-of-endobronchial-ultrasound-in-patients-with-human-immunodeficiency-virus-infection-and-mediastinal-lymphadenopathy
#20
Olivia Sánchez-Cabral, Dina Martínez-Mendoza, Sebastian Fernandez-Bussy, Esmeralda Aspuru-García, Rosa Rivera-Rosales, César Luna-Rivero, José Arturo Martínez-Orozco, Gustavo Reyes-Terán
BACKGROUND: There are few published studies about the usefulness of endobronchial ultrasound (EBUS) in patients infected with human immunodeficiency virus (HIV). The clinical spectrum of likely diseases in this population is varied and differs from patients not infected with HIV. OBJECTIVE: The aim of this study was to measure the usefulness of EBUS-guided transbronchial needle aspiration (EBUS-TBNA) in HIV-infected patients with mediastinal lymphadenopathy. MATERIALS AND METHODS: We conducted an observational, cross-sectional, retrospective, descriptive study on patients with HIV infection and mediastinal lymphadenopathy who underwent EBUS-TBNA between September 2014 and April 2016...
March 30, 2017: Respiration; International Review of Thoracic Diseases
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