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inflamation in ckd

Karin Luttropp, Malgorzata Debowska, Tomasz Lukaszuk, Leon Bobrowski, Juan Jesus Carrero, Abdul Rashid Qureshi, Peter Stenvinkel, Bengt Lindholm, Jacek Waniewski, Louise Nordfors
BACKGROUND: In complex diseases such as chronic kidney disease (CKD), the risk of clinical complications is determined by interactions between phenotypic and genotypic factors. However, clinical epidemiological studies rarely attempt to analyse the combined effect of large numbers of phenotype and genotype features. We have recently shown that the relaxed linear separability (RLS) model of feature selection can address such complex issues. Here, it is applied to identify risk factors for inflammation in CKD...
April 19, 2016: Nephrology, Dialysis, Transplantation
Akihiro Yoshihara, Masanori Iwasaki, Hideo Miyazaki, Kazutoshi Nakamura
OBJECTIVES: The purpose of this study was to evaluate the reciprocal effects of chronic kidney disease (CKD) and periodontal disease. MATERIAL AND METHODS: A total of 332 postmenopausal never smoking women were enrolled, and their serum high-sensitivity C-reactive protein, serum osteocalcin and serum cystatin C levels were measured. Poor renal function was defined as serum cystatin C > 0.91 mg/l. Periodontal disease markers, including clinical attachment level and the periodontal inflamed surface area (PISA), were also evaluated...
September 2016: Journal of Clinical Periodontology
Jan Rossaint, Jessica Oehmichen, Hugo Van Aken, Stefan Reuter, Hermann J Pavenstädt, Melanie Meersch, Mark Unruh, Alexander Zarbock
Chronic kidney disease (CKD) has been associated with impaired host response and increased susceptibility to infections. Leukocyte recruitment during inflammation must be tightly regulated to protect the host against pathogens. FGF23 levels are increased in blood during CKD, and levels of this hormone have been associated with a variety of adverse effects in CKD patients. Here, we have shown that CKD impairs leukocyte recruitment into inflamed tissue and host defense in mice and humans. FGF23 neutralization during CKD in murine models restored leukocyte recruitment and host defense...
March 1, 2016: Journal of Clinical Investigation
Sonja Vuč Ković, Katarina Savić Vujović, Dragana Srebro, Branislava Medić, Tatjana Ilic-Mostic
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed for the treatment of pain, inflamation and fever. They are usually well tolerated in healthy persons, but in patients with risk factors (advanced age, renal impairment, heart failure, liver disease, concurrent medications with antihypertensive drugs), NSAIDs can induce serious renal adverse effects. They include sodium and water retention with edema, worsening of heart failure, hypertension, hyponatremia, hyperkalemia, acute kidney injury, chronic kidney disease, renal papillary necrosis and acute interstitial nephritis...
2016: Current Medicinal Chemistry
Yan Sun, Yiping Wang, Qi Cao, Hong Yu, Dong Zheng, Ya Wang, David C H Harris
BACKGROUND: CD166, an adhesion molecule of the immunoglobulin superfamily, is one of the crucial effectors that traffic lymphocytes into tissues. Till now, the expression and role of CD166 in the chronic kidney disease remains unknown. OBJECTIVES: In the present study, we are to examine the expression of CD166 in the chronic kidney disease, and to explore its function with CD4+ T cells. MATERIALS AND METHODS: CD166 expression was tested by Flow Cytometry (FACS) in the primary macrophages stimulated with LPS...
October 2015: Iranian Journal of Pediatrics
Anna Machowska, Juan Jesus Carrero, Bengt Lindholm, Peter Stenvinkel
Systemic inflammation is a condition intrinsically linked to chronic kidney disease (CKD) and its other typical sequelae, such as acquired immune dysfunction, protein-energy wasting (PEW), and accelerated vascular aging that promote premature cardiovascular disease (CVD) and infections, the two leading causes of death in CKD patients. Inflammation is a major contributor to complications in CKD, and inflammatory markers, such as C-reactive protein and pro- and anti-inflammatory cytokines, correlate with underlying causes and consequences of the inflamed uremic phenotype, such as oxidative stress, endothelial dysfunction, CVD, PEW, and infections, and are sensitive and independent predictors of outcome in CKD...
January 2016: Translational Research: the Journal of Laboratory and Clinical Medicine
Konrad Buscher, Gert Gabriëls, Peter Barth, Hermann Pavenstädt
A 63-year-old woman presented with progredient bilateral breast pain. Her medical history included rheumatoid arthritis, AA amyloidosis and end-stage renal disease treated by peritoneal dialysis. Inflamed skin alterations of the breast and laboratory values suggested mastitis non-puerpuralis but antibiotics did not resolve the symptoms. Sonography and mammography showed severe vessel calcification suggesting calcific uraemic arteriolopathy (calciphylaxis) as a rare complication of chronic kidney disease. Treatment included intensified haemodialysis, thiosulfate application, analgaesia and wound management leading to significant improvement, however, without complete remission...
2015: BMJ Case Reports
Adrian-Bogdan Ghigolea, Raluca Argentina Moldovan, Mirela Gherman-Caprioara
Aberrant DNA methylation is an emerging characteristic of chronic kidney disease including dialysis patients. It appears to be associated to inflammation. We compared the global DNA methylation status in 10 control subjects compared to 80 dialysis patients (N = 40 on-line hemodiafiltration, N = 40 high-flux hemodialysis) in relation to the dialysis technique and inflammation. Whole blood DNA methylation was assessed with a 5-mc DNA enzyme linked immunosorbent assay Kit. Global DNA methylation was higher in hemodialysis (HD) compared to on-line hemodiafiltration (HDF) patients (0...
April 2015: Therapeutic Apheresis and Dialysis
L Orlić, I Mikolasevic, Z Bagic, S Racki, D Stimac, S Milic
Research in recent years has led to the recognition of the importance of nonalcoholic fatty liver disease (NAFLD) and its relationship to the metabolic syndrome (MS). This has led to a growing interest in the potential prognostic value of NAFLD for adverse cardiovascular disease (CVD) outcome. On the other hand, searching for new risk factors for chronic kidney disease (CKD) development and progression is very important. Growing evidence suggests that the MS is an important factor in the pathogenesis of CKD...
2014: Gastroenterology Research and Practice
Antonio C Cordeiro, Bengt Lindholm, Márcio G Sousa, Juliano C Picotti, Gabriel J Nunes, Marcus R O Santana, Waldyr Grimaldi, Fernanda C Amparo, Celso Amodeo, Juan J Carrero
OBJECTIVE: Left ventricular hypertrophy (LVH) is a prevalent condition in chronic kidney disease (CKD) very often underdiagnosed and misdiagnosed. Electrocardiography (ECG) is an easily accessible LVH diagnostic tool. We evaluated the usefulness of commonly applied ECG criteria for LVH diagnosis in CKD patients. METHODS: Cross-sectional evaluation of 253 nondialysis-dependent CKD stages 3-5 patients (61 [53-67] years; 65% men). Left ventricular mass (LVM) was assessed by echocardiography (ECHO)...
February 2014: Journal of Hypertension
I Mikolasevic, S Racki, V Lukenda, M Pavletic-Persic, S Milic, L Orlic
Despite all improvements in transplant medicine, renal transplant recipients have a high risk for cardiovascular mortality. A high prevalence of cardiovascular complications in renal transplant recipients (RTR) is explained by cardiovascular risk factors present before transplantation, in addition to the development of new risk factors as well as worsening of preexisting risk factors after transplantation. A majority ot these patients develop metabolic syndrome within a year after the transplantation. The metabolic syndrome (MS) is associated with impaired renal allograft function and increased insulin resistance...
January 2014: Medical Hypotheses
Antonio Carlos Cordeiro, Abdul Rashid Qureshi, Bengt Lindholm, Fernanda Cassullo Amparo, Antonio Tito-Paladino-Filho, Marcela Perini, Fernanda Silvestre Lourenço, Ibraim Masciarelli Francisco Pinto, Celso Amodeo, Juan Jesús Carrero
BACKGROUND: Abdominal fat is a metabolically active tissue which has been associated with cardiovascular events and death in chronic kidney disease (CKD) patients. We explore here the association between surrogates of abdominal fat and coronary artery calcium score (CACs). METHODS: Cross-sectional analysis of 232 non-dialysis-dependent CKD patients Stages 3-5 (median age 60 [25th-75th percentile 52-67] years; 60% men). Visceral adipose tissue (VAT) and CACs were assessed by computed tomography...
November 2013: Nephrology, Dialysis, Transplantation
Jiangzi Yuan, Qunying Guo, Abdul Rashid Qureshi, Björn Anderstam, Monica Eriksson, Olof Heimbürger, Peter Bárány, Peter Stenvinkel, Bengt Lindholm
BACKGROUND: Vascular endothelial growth factor (VEGF) and its soluble receptor 1 (sVEGFR-1) predict mortality in nondialyzed chronic kidney disease (CKD) stage 3-5 patients and prevalent hemodialysis (HD) patients. We investigated determinants of VEGF and sVEGFR-1 as well as their relationship with all-cause mortality in incident dialysis patients. METHODS: In this longitudinal cohort study of 211 CKD 5 patients [64% males, mean age of 54 ± 12 years and median glomerular filtration rate (GFR) 5...
September 2013: Nephrology, Dialysis, Transplantation
Tarcio Teodoro Braga, Matheus Correa-Costa, Yuri Felipe Souza Guise, Angela Castoldi, Cassiano Donizetti de Oliveira, Meire Ioshie Hyane, Marcos Antonio Cenedeze, Simone Aparecida Teixeira, Marcelo Nicolas Muscara, Katia Regina Perez, Iolanda Midea Cuccovia, Alvaro Pacheco-Silva, Giselle Martins Gonçalves, Niels Olsen Saraiva Camara
Inflammation contributes to the pathogenesis of chronic kidney disease (CKD). Molecules released by the inflamed injured tissue can activate toll-like receptors (TLRs), thereby modulating macrophage and CD4(+) T-cell activity. We propose that in renal fibrogenesis, M2 macrophages are recruited and activated in a T helper subset 2 cell (T(H)2)-prone inflammatory milieu in a MyD88-dependent manner. Mice submitted to unilateral ureteral ligation (UUO) demonstrated an increase in macrophage infiltration with collagen deposition after 7 d...
2012: Molecular Medicine
Enzo Bonora, Giovanni Targher
NAFLD is very common in the general population and its prevalence is increasing worldwide in parallel with the increasing incidences of obesity and metabolic diseases, mainly type 2 diabetes. In some cases, however, the diagnosis of NAFLD remains uncertain because other causes of liver disease are not easy to exclude in patients who are diagnosed with NAFLD after a biochemical or ultrasonographic analysis. Several studies have documented a strong association between NAFLD and traditional and nontraditional risk factors for cardiovascular disease (CVD) and chronic kidney disease (CKD)...
July 2012: Nature Reviews. Gastroenterology & Hepatology
Giovanni Targher, Michel Chonchol, Giacomo Zoppini, Cataldo Abaterusso, Enzo Bonora
Non-alcoholic fatty liver disease (NAFLD) has emerged as a growing public health problem worldwide. Increasing recognition of the importance of NAFLD and its association with the features of the metabolic syndrome has stimulated an interest in its putative role in the development and progression of chronic kidney disease (CKD). Accumulating evidence suggests that NAFLD and CKD share many important cardio-metabolic risk factors and common pathogenetic mechanisms and that NAFLD is associated with an increased prevalence and incidence of CKD...
May 2011: Journal of Hepatology
Pedro L Neves, Anabela Malho, Ana Cabrita, Ana Pinho, Alexandre Baptista, Elsa Morgado, Marília Faísca, Hermínio Carrasqueira, Ana P Silva
The increased mortality rate observed in patients with chronic kidney disease is related to the high prevalence of cardiovascular disease in this population. Recently, it has been shown that interventional therapy with statins and/or vitamin D could improve the outcomes of these patients. The aim of this study was to identify the risk factors for mortality in a group of patients with chronic kidney disease (stages 4 and 5--pre-dialysis) and verify whether vitamin D and statins could change the outcome. We included 95 patients (mean age--69...
March 2010: International Urology and Nephrology
Annette Bruchfeld, Juan J Carrero, Abdul R Qureshi, Bengt Lindholm, Peter Barany, Olof Heimburger, Maowen Hu, Xinchun Lin, Peter Stenvinkel, Edmund J Miller
Chronic kidney disease (CKD) carries an increased risk of cardiovascular disease (CVD). Macrophage migration inhibiting factor (MIF) is a proinflammatory cytokine implicated in the pathogenesis of sepsis, autoimmune disease, atherogenesis, and plaque instability, and is a known cardiac depressant. This post-hoc, cross-sectional study examined whether MIF serum concentrations are elevated in CKD patients. Our study included CKD 3-5 patients with moderate to severe renal dysfunction (n = 257) (mean age SD; 55 +/- 12 years) and 53 controls (60 +/- 12 years)...
March 2009: Molecular Medicine
G Metry, P Stenvinkel, A R Qureshi, J J Carrero, M I Yilmaz, P Bárány, S Snaedal, O Heimbürger, B Lindholm, M E Suliman
BACKGROUND: Fetuin-A, a negative acute phase protein that inhibits vascular calcification, has a controversial association with mortality in chronic kidney disease (CKD) patients. Chronic inflammation, which is common in CKD, may promote vascular calcification. MATERIALS AND METHODS: We investigated the impact of inflammation on the relationship between serum fetuin-A and mortality (42 months) in 222 prevalent haemodialysis (HD) patients. RESULTS: Serum fetuin correlated negatively with comorbidity score (assessed by Davies score) and circulating inflammatory markers...
November 2008: European Journal of Clinical Investigation
Amy Wing Yin Ho, Chun Kwok Wong, Christopher Wai Kei Lam
Both circulating and urinary tumor necrosis factor (TNF)-alpha levels have been shown to increase in inflammatory chronic kidney diseases and TNF-alpha can induce secretion of other inflammatory mediators from many cell types. Chemokine, mononuclear chemoattractant protein-1 (CCL2/MCP-1), and cell surface adhesion molecules, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), in renal proximal tubular epithelial cells (PTEC) are important for promoting recruitment and adhesion of infiltrating macrophages and lymphocytes to inflamed renal tissue...
2008: Immunobiology
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