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https://www.readbyqxmd.com/read/28820504/diabetes-insulin-pumps-after-injections-and-cgm-in-t1dm
#1
John C Pickup
No abstract text is available yet for this article.
August 18, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28816535/professional-continuous-flash-glucose-monitoring-with-ambulatory-glucose-profile-reporting-to-supplement-a1c-rationale-and-practical-implementation
#2
Irl B Hirsch, Carol A Verderese
OBJECTIVE: Recent consensus statements strongly advocate downloading and interpretation of continuous glucose data for diabetes management in patients with type 1 or type 2 diabetes. Supplementing periodic A1C testing with intermittent continuous glucose monitoring (CGM) using a standardized report form known as the ambulatory glucose profile (AGP) is an evolving standard of care. The rationale for this approach and its implementation with a recently approved novel monitoring technology are explored...
August 17, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28802292/even-minimal-polishing-of-an-indian-parboiled-brown-rice-variety-leads-to-increased-glycemic-responses
#3
Shanmugam Shobana, Nagarajan Lakshmipriya, Mookambika Ramya Bai, Rajagopal Gayathri, Vaidya Ruchi, Vasudevan Sudha, Nagappa G Malleshi, Kamala Krishnaswamy, C-J K Henry, Ranjit Mohan Anjana, Ranjit Unnikrishnan, Viswanathan Mohan
BACKGROUND AND OBJECTIVES: To evaluate the effect of polishing on the glycemic properties of Indian parboiled brown rice. METHODS AND STUDY DESIGN: We evaluated the effect of different degrees of polishing on the glycemic and insulinemic responses of Bapatla (BPT-5204), Indian parboiled Indica rice variety. Brown rice (BR), under milled rice (UMR) and white rice (WR) with 2.3% and 9.7% degree of polishing (DOP), respectively, were prepared and evaluated for the glycemic properties...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28792665/beyond-a1c
#4
EDITORIAL
Zachary T Bloomgarden
The diaTribe Foundation convened a meeting on the topic of discuss glycemic outcomes beyond A1C on July 21, 2017, in Bethesda, MD, focusing on potential uses of continuous glucose monitoring (CGM). Understanding patterns of glycemia in persons with diabetes has long been a focus of approaches to improving treatment ((2) ), and over the past few years this has become an available modality for clinical practice ((3) ). Glucose levels are not the only biologic parameters affecting A1c levels.
August 9, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28790929/combined-interval-training-and-post-exercise-nutrition-in-type-2-diabetes-a-randomized-control-trial
#5
Monique E Francois, Cody Durrer, Kevin J Pistawka, Frank A Halperin, Courtney Chang, Jonathan P Little
Background: High-intensity interval training (HIIT) can improve several aspects of cardiometabolic health. Previous studies have suggested that adaptations to exercise training can be augmented with post-exercise milk or protein consumption, but whether this nutritional strategy can impact the cardiometabolic adaptations to HIIT in type 2 diabetes is unknown. Objective: To determine if the addition of a post-exercise milk or protein beverage to a high-intensity interval training (HIIT) intervention improves cardiometabolic health in individuals with type 2 diabetes...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28781778/glucose-metabolism-before-and-after-radioiodine-therapy-of-a-patient-with-graves-disease-assessment-by-continuous-glucose-monitoring
#6
Yun Hu, Gu Gao, Reng-Na Yan, Feng-Fei Li, Xiao-Fei Su, Jian-Hua Ma
Hyperthyroidism causes impaired glucose tolerance, insulin resistance (IR) and insulin secretion. However, the glucose variability affected by thyroid dysfunction remains unclear. Glucose variability was assessed by continuous glucose monitoring (CGM) in a non-diabetic patient with Graves' disease (GD), to the best of our knowledge, for the first time. A 28-year-old man with GD, who had been taking methimazole for 4 years, was treated with radioiodine on August 17th 2016. Although the patient exhibited normal glycated hemoglobin (HbA1c; 5...
August 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28771387/minimizing-glycemic-fluctuations-in-patients-with-type-2-diabetes-approaches-and-importance
#7
Paresh Dandona
Glycemic fluctuations, characterized by short-term oscillations in plasma glucose, are important when managing type 2 diabetes (T2D) and may be considered a target of glucose-lowering therapies. Continuous glucose monitoring (CGM) has been used to evaluate the effects of different treatments on glycemic fluctuations. This review examines approaches to and the importance of minimizing glycemic fluctuations among patients with T2D. Measures of HbA1c, fructosamine, and glycated albumin reflect a long-term average of plasma glucose, and are therefore unable to provide an accurate measure of short-term glycemic oscillations...
August 3, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28770627/management-and-family-burdens-endorsed-by-parents-of-youth-7-years-old-with-type-1-diabetes
#8
Kara R Harrington, Claire T Boyle, Kellee M Miller, Marisa E Hilliard, Barbara J Anderson, Michelle Van Name, Linda A DiMeglio, Lori M Laffel
BACKGROUND: This study investigated unique burdens experienced by parents of young children with type 1 diabetes in the context of contemporary diabetes management. METHODS: Self-report surveys and medical record information from the T1D Exchange clinic registry were used. Parental burden and family impact scores were tabulated across demographic and clinical characteristics, overall and according to age group (<4, 4-<6, and 6-<7 years). RESULTS: The mean age of the 597 children was 5...
August 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28767276/closed-loop-control-without-meal-announcement-in-type-1-diabetes
#9
Faye M Cameron, Trang T Ly, Bruce A Buckingham, David M Maahs, Gregory P Forlenza, Carol J Levy, David Lam, Paula Clinton, Laurel H Messer, Emily Westfall, Camilla Levister, Yan Yan Xie, Nihat Baysal, Daniel Howsmon, Stephen D Patek, B Wayne Bequette
OBJECTIVE: A fully closed-loop insulin-only system was developed to provide glucose control in patients with type 1 diabetes without requiring announcement of meals or activity. Our goal was to assess initial safety and efficacy of this system. RESEARCH DESIGN AND METHODS: The multiple model probabilistic controller (MMPPC) anticipates meals when the patient is awake. The controller used the subject's basal rates and total daily insulin dose for initialization. The system was tested at two sites on 10 patients in a 30-h inpatient study, followed by 15 subjects at three sites in a 54-h supervised hotel study, where the controller was challenged by exercise and unannounced meals...
August 2, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28761664/glucose-lowering-effect-of-whey-protein-depends-upon-clinical-characteristics-of-patients-with-type-2-diabetes
#10
Rogelio U Almario, Wendy M Buchan, David M Rocke, Sidika E Karakas
OBJECTIVE: Whey protein (WP) intake has been shown to reduce postprandial glycemia. Majority of WP research in type 2 diabetes (T2DM) involved acute challenge or weight loss studies. It is not known if WP supplementation can provide sustained glucose lowering. Our goal was to investigate the effects of WP on glycemia comprehensively by using continuous glucose monitoring (CGM) while avoiding the confounding effects of variable food intake through controlled feeding. RESEARCH DESIGN AND METHODS: This double-blinded and placebo (PL)-controlled study included 22 patients with T2DM patients (11 male, 11 female; age 57...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28756769/continuous-glucose-monitoring-in-the-icu-clinical-considerations-and-consensus
#11
REVIEW
James S Krinsley, J Geoffrey Chase, Jan Gunst, Johan Martensson, Marcus J Schultz, Fabio S Taccone, Jan Wernerman, Julien Bohe, Christophe De Block, Thomas Desaive, Pierre Kalfon, Jean-Charles Preiser
Glucose management in intensive care unit (ICU) patients has been a matter of debate for almost two decades. Compared to intermittent monitoring systems, continuous glucose monitoring (CGM) can offer benefit in the prevention of severe hyperglycemia and hypoglycemia by enabling insulin infusions to be adjusted more rapidly and potentially more accurately because trends in glucose concentrations can be more readily identified. Increasingly, it is apparent that a single glucose target/range may not be optimal for all patients at all times and, as with many other aspects of critical care patient management, a personalized approach to glucose control may be more appropriate...
July 31, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28750219/continuous-glucose-monitoring-detected-hypoglycaemia-in-the-treating-to-target-in-type-2-diabetes-trial-4-t
#12
J C Levy, M J Davies, R R Holman
AIMS: Hypoglycaemia is a significant risk in insulin treated type 2 diabetes and has been associated with future risk of cardiovascular events. We compared the frequency of low-glucose events using continuous glucose monitoring (CGM) with that of self-reported hypoglycemic events at the end of the first and third years of the Treating to Target in Type 2 Diabetes Trial (4-T), which compared biphasic, prandial and basal insulin regimens added to sulfonylurea and metformin. METHODS: CGM using a Medtronic Gold system was performed in a subgroup of 4-T participants...
March 21, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28748706/the-development-of-new-composite-metrics-for-the-comprehensive-analytic-and-visual-assessment-of-hypoglycemia-using-the-hypo-triad
#13
Andreas Thomas, John Shin, Boyi Jiang, Chantal McMahon, Ralf Kolassa, Robert A Vigersky
BACKGROUND: Quantifying hypoglycemia has traditionally been limited to using the frequency of hypoglycemic events during a given time interval using data from blood glucose (BG) testing. However, continuous glucose monitoring (CGM) captures three parameters-a Hypo-Triad-unavailable with BG monitoring that can be used to better characterize hypoglycemia: area under the curve (AUC), time (duration of hypoglycemia), and frequency of daily episodes below a specified threshold. METHODS: We developed two new analytic metrics to enhance the traditional Hypo-Triad of CGM-derived data to more effectively capture the intensity of hypoglycemia (IntHypo) and overall hypoglycemic environment called the "hypoglycemia risk volume" (HypoRV)...
July 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28745578/cost-effectiveness-of-g5-mobile-continuous-glucose-monitoring-cgm-device-compared-with-self-monitoring-of-blood-glucose-smbg-alone-for-people-with-type-1-diabetes-from-the-canadian-societal-perspective
#14
Shraddha Chaugule, Claudia Graham
AIMS: To evaluate the cost-effectiveness of real-time continuous glucose monitoring (CGM) compared to self-monitoring of blood glucose (SMBG) alone in people with type 1 diabetes (T1DM) using multiple daily injections (MDI) from the Canadian societal perspective. METHODS: The IMS CORE Diabetes Model (v.9.0) was used to assess the long-term (50 years) cost-effectiveness of real-time CGM (G5 Mobile CGM System; Dexcom, Inc., San Diego, CA) compared with SMBG alone for a cohort of adults with poorly-controlled T1DM...
July 26, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28745098/analysis-of-the-accuracy-and-performance-of-a-continuous-glucose-monitoring-sensor-prototype-an-in-silico-study-using-the-uva-padova-type-1-diabetes-simulator
#15
Marc D Breton, Rolf Hinzmann, Enrique Campos-Nañez, Susan Riddle, Michael Schoemaker, Guenther Schmelzeisen-Redeker
BACKGROUND: Computer simulation has been shown over the past decade to be a powerful tool to study the impact of medical devices characteristics on clinical outcomes. Specifically, in type 1 diabetes (T1D), computer simulation platforms have all but replaced preclinical studies and are commonly used to study the impact of measurement errors on glycemia. METHOD: We use complex mathematical models to represent the characteristics of 3 continuous glucose monitoring systems using previously acquired data...
May 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28745093/optimal-use-of-diabetes-devices-clinician-perspectives-on-barriers-and-adherence-to-device-use
#16
Molly L Tanenbaum, Rebecca N Adams, Sarah J Hanes, Regan C Barley, Kellee M Miller, Shelagh A Mulvaney, Korey K Hood
BACKGROUND: Insulin pumps and continuous glucose monitors (CGM) can improve glycemic control for individuals with type 1 diabetes (T1D). Device uptake rates continue to show room for improvement, and consistent adherence is needed to achieve better outcomes. Diabetes health care providers have important roles to play in promoting device use and adherence. METHODS: We surveyed 209 clinicians who treat people with type 1 diabetes to examine perceptions of barriers to device uptake, attitudes toward diabetes technology, and resources needed for clinicians to improve device uptake...
May 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28745088/replacement-of-blood-glucose-measurements-by-measurements-with-systems-for-real-time-continuous-glucose-monitoring-rtcgm-or-cgm-with-intermittent-scanning-isccgm-a-german-view
#17
Guido Freckmann, Sandra Schlüter, Lutz Heinemann
No abstract text is available yet for this article.
July 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28740090/chaotic-time-series-prediction-for-glucose-dynamics-in-type-1-diabetes-mellitus-using-regime-switching-models
#18
Mirela Frandes, Bogdan Timar, Romulus Timar, Diana Lungeanu
In patients with type 1 diabetes mellitus (T1DM), glucose dynamics are influenced by insulin reactions, diet, lifestyle, etc., and characterized by instability and nonlinearity. With the objective of a dependable decision support system for T1DM self-management, we aim to model glucose dynamics using their nonlinear chaotic properties. A group of patients was monitored via continuous glucose monitoring (CGM) sensors for several days under free-living conditions. We assessed the glycemic variability (GV) and chaotic properties of each time series...
July 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28733374/the-fallacy-of-average-how-using-hba1c-alone-to-assess-glycemic-control-can-be-misleading
#19
Roy W Beck, Crystal G Connor, Deborah M Mullen, David M Wesley, Richard M Bergenstal
HbA1c is a valuable metric for comparing treatment groups in a randomized trial, for assessing glycemic trends in a population over time, or for cross-sectional comparisons of glycemic control in different populations. However, what is not widely appreciated is that HbA1c may not be a good indicator of an individual patient's glycemic control because of the wide range of mean glucose concentrations and glucose profiles that can be associated with a given HbA1c level. To illustrate this point, we plotted mean glucose measured with continuous glucose monitoring (CGM) versus central laboratory-measured HbA1c in 387 participants in three randomized trials, showing that not infrequently HbA1c may underestimate or overestimate mean glucose, sometimes substantially...
August 2017: Diabetes Care
https://www.readbyqxmd.com/read/28731509/keeping-safe-continuous-glucose-monitoring-cgm-in-persons-with-type-1-diabetes-and-impaired-awareness-of-hypoglycaemia-a-qualitative-study
#20
A F Vloemans, C A J van Beers, M de Wit, W Cleijne, S M Rondags, P H Geelhoed-Duijvestijn, M H H Kramer, E H Serné, F J Snoek
AIM: To further our understanding of individual use and experience of continuous glucose monitoring (CGM) in adults with Type 1 diabetes and impaired awareness of hypoglycaemia, we conducted a qualitative study supplementary to a randomized controlled trial, using semi-structured interviews. METHODS: Twenty-three participants of the IN CONTROL trial were interviewed within 4 weeks after the last study visit. The interview centred around experiences of CGM, taking into account the person's expectations prior to the trial...
July 21, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
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