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https://www.readbyqxmd.com/read/29772654/consistency-of-continuous-ambulatory-interstitial-glucose-monitoring-sensors
#1
Pei T Wu, David E Segovia, Cathy C Lee, Kim-Lien Nguyen
AIMS: The abdominal region is the most common location for continuous glucose monitor (CGM) sensor insertion. However, a paucity of post-marketing data is available to demonstrate intra-individual consistency of CGM readings at different abdominal insertion sites. METHODS: Healthy adults (fasting glucose (FG) < 5.5 mmol/L; BMI < 30 kg/m²) were recruited and a CGM sensor was placed on each side of the abdomen. Postprandial and continuous 48-h interstitial glucose levels were analyzed...
May 16, 2018: Biosensors
https://www.readbyqxmd.com/read/29770541/effect-of-short-term-treatment-with-sitagliptin-or-glibenclamide-on-daily-glucose-fluctuation-in-drug-na%C3%A3-ve-japanese-patients-with-type-2-diabetes-mellitus
#2
Ryo Suzuki, Jun-Ichi Eiki, Takashi Moritoyo, Kenichi Furihata, Akira Wakana, Yukari Ohta, Shigeru Tokita, Takashi Kadowaki
AIMS: To compare the effect of a dipeptidyl peptidase-4 inhibitor (DPP4-i) and a sulfonylurea (SU) on daily glucose fluctuation in drug-naïve Japanese patients with type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: Fifty-three drug-naïve Japanese patients with T2DM (HbA1c of 7.0% to 9.0% and fasting plasma glucose of 6.1 mmol/L or higher) were randomly assigned to either sitagliptin 50 mg q.d. or glibenclamide 2.5 mg per day (given in divided doses) in a 1:1 ratio...
May 17, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29753586/cost-effectiveness-of-sensor-augmented-pump-therapy-in-two-different-patient-populations-with-type-1-diabetes-in-italy
#3
A Nicolucci, M C Rossi, D D'Ostilio, A Delbaere, S de Portu, S Roze
BACKGROUND AND AIMS: Sensor-augmented pump therapy (SAP) combines real time continuous glucose monitoring (CGM) with Continuous Subcutaneous Insulin Infusion (CSII) and provides additional benefits beyond those provided by CSII alone. SAP with automated insulin suspension provides early warning of the onset of hyperglycemia and hypoglycemia and has the functionality to suspend insulin delivery if sensor glucose levels are predicted to fall below a predefined threshold. Aim of this study was to assess the cost-effectiveness of SAP with automated insulin suspension versus CSII alone in type 1 diabetes...
April 5, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29749032/comparison-between-preprandial-versus-postprandial-insulin-aspart-administration-in-patients-with-type-1-diabetes-benefiting-from-insulin-pump-and-real-time-continuous-glucose-monitoring
#4
Philippe Thuillier, Emmanuel Sonnet, Zarrin Alavi, Nathalie Roudaut, Emmanuel Nowak, Angélina Dion, Véronique Kerlan
BACKGROUND: The objective was to compare glycemic control between pre- and post-prandial bolus administration (15min before (PRE) or immediately after the meal (POST)) in patients with type 1 diabetes using insulin pump and real time continuous glucose monitoring (RT-CGM). METHODS: Between September 2015 and February 2016, a single-centre, open randomized, two-way crossover study of patients on bolus insulin aspart administration was conducted during two 14-days periods and according to two administration regimen schedules(...
May 10, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29733419/net-energy-content-of-rice-bran-defatted-rice-bran-corn-gluten-feed-and-corn-germ-meal-fed-to-growing-pigs-using-indirect-calorimetry
#5
Zhiqian Lyu, Yakui Li, Hu Liu, Enkai Li, Peili Li, Shuai Zhang, Fenglai Wang, Changhua Lai
The objective of this experiment was to determine the effects of increased fiber content in diets on heat production (HP) and NE:ME ratio and to determine the NE content and NE:ME ratio of full-fat rice bran (FFRB), defatted rice bran (DFRB), corn gluten feed (CGF), and corn germ meal (CGM) fed to growing barrows using indirect calorimetry (IC). Thirty growing barrows (28.5 ± 2.4 kg BW) were allotted in a completely randomized design to 5 dietary treatments that included a corn-soybean meal basal diet and 4 experimental diets with a constant ratio of corn and soybean meal (difference method) containing 30% FFRB, DFRB, CGF, and CGF...
May 4, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29730390/pre-exercise-blood-glucose-affects-glycemic-variation-of-aerobic-exercise-in-patients-with-type-2-diabetes-treated-with-continuous-subcutaneous-insulin-infusion
#6
Yun Hu, Dan-Feng Zhang, Lu Dai, Zheng Li, Hui-Qin Li, Feng-Fei Li, Bing-Li Liu, Xiao-Juan Sun, Lei Ye, Ke He, Jian-Hua Ma
AIMS: Considering the insulin sensitivity may increase by exercise particularly in patients with type 2 diabetes (T2D), glycemic variation during exercise needs to be studied when the patients are treated with insulin. This study aimed to explore the influence factors of the efficacy and safety of aerobic exercise in patients with T2D treated with Continuous Subcutaneous Insulin Infusion (CSII). METHODS: A total of 267 patients with T2D, treated with CSII, were included...
May 3, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29728302/clinically-significant-cognitive-impairment-in-older-adults-with-type-1-diabetes
#7
Naomi S Chaytor, Celestina Barbosa-Leiker, Christopher M Ryan, Laura T Germine, Irl B Hirsch, Ruth S Weinstock
AIMS: Little is known about cognition in older adults with type 1 diabetes. The aim of this study was to identify correlates of clinically significant cognitive impairment. METHODS: Neuropsychological, diabetes-related and glycemic (HbA1c, Continuous Glucose Monitoring; CGM) data were collected from 201 older adults (≥60 years) with longstanding type 1 diabetes. RESULTS: Clinically significant cognitive impairment (≥2 cognitive tests ≥1...
April 14, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29727245/baseline-psychosocial-characteristics-predict-frequency-of-continuous-glucose-monitoring-in-youth-with-type-1-diabetes
#8
Dayna E McGill, Lisa K Volkening, Deborah A Butler, Kara R Harrington, Michelle L Katz, Lori M Laffel
BACKGROUND: Consistent use of continuous glucose monitoring (CGM) has been associated with improved glycemic control in youth with type 1 diabetes (T1D). There are many barriers to device uptake and continued use. There is a need to understand patient-specific characteristics when considering CGM. We evaluated patterns of CGM use and associations between baseline psychosocial measures and frequency of CGM use over 1 year. METHODS: Youth with T1D (n = 120), ages 8-18 years, completed questionnaires at CGM initiation and after 6 and 12 months assessing depressive symptoms, diabetes burden, and diabetes-specific and generic quality of life (QOL)...
May 4, 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29725320/cardiovascular-autonomic-neuropathy-and-glucose-variability-in-patients-with-type-1-diabetes-is-there-an-association
#9
Szabolcs Nyiraty, Fruzsina Pesei, Andrea Orosz, Sara Coluzzi, Orsolya Eszter Vági, Csaba Lengyel, György Ábrahám, Simona Frontoni, Peter Kempler, Tamás Várkonyi
Introduction: The oxidative stress associated with glucose variability might be responsible for neuronal damage while autonomic neuropathy (AN) has a detrimental effect on metabolism. The aim of the study was to find relationship between AN and GV in type 1 diabetic patients and to identify further factors that affect GV. Patients and methods: Twenty type 1 diabetic patients were involved (age: 39.5 ± 3.4 years, duration of diabetes: 17.5 ± 2.5 years; HbA1c: 8...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29719294/preterm-glycosuria-new-data-from-a-continuous-glucose-monitoring-system
#10
Mateusz Jagła, Izabela Szymońska, Katarzyna Starzec, Przemko Kwinta
BACKGROUND: Careful control of glucose homeostasis is essential for infants with very low birth weight (VLBW). In clinical practice, blood and urine glucose levels are monitored; however, their correlation has not been fully investigated in VLBW infants. OBJECTIVES: To evaluate the correlation between interstitial fluid glucose concentration (ISFG), glycosuria, and urine output among VLBW infants through continuous glucose monitoring (CGM). METHODS: A prospective, single-center, open cohort study enrolled 74 VLBW infants with a mean birth weight of 1,066 g...
May 2, 2018: Neonatology
https://www.readbyqxmd.com/read/29709336/short-term-metabolic-control-and-sleep-in-children-and-adolescents-with-type-1-diabetes-mellitus
#11
Martina Kostkova, Peter Durdik, Miriam Ciljakova, Jarmila Vojtkova, Anna Sujanska, Katarina Pozorciakova, Zuzana Snahnicanova, Maria Jancinova, Peter Banovcin
AIMS: The aim of this study was to examine sleep in T1D children and in healthy controls by polysomnographic (PSG) examination and to determine the influence of short-term metabolic compensation on sleep quality and sleep disordered breathing (SDB). METHODS: The prospective cross-sectional study included 44 T1D subjects and 60 healthy controls, aged 10-19 years. Subjects underwent anthropometric measurements, laboratory testing and standard overnight in-laboratory video polysomnography with continuous glucose monitoring (CGM)...
March 22, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29693557/continuous-glucose-monitoring-in-resource-constrained-settings-for-hypoglycaemia-detection-looking-at-the-problem-from-the-other-side-of-the-coin
#12
Rubao Bila, Rosauro Varo, Lola Madrid, Antonio Sitoe, Quique Bassat
The appearance, over a decade ago, of continuous glucose monitoring (CGM) devices has triggered a patient-centred revolution in the control and management of diabetes mellitus and other metabolic conditions, improving the patient&rsquo;s glycaemic control and quality of life. Such devices, the use of which remains typically restricted to high-income countries on account of their elevated costs, at present show very limited implantation in resource-constrained settings, where many other urgent health priorities beyond diabetes prevention and management still need to be resolved...
April 25, 2018: Biosensors
https://www.readbyqxmd.com/read/29692968/pilot-data-on-responsive-epilepsy-neurostimulation-measures-of-sleep-apnea-and-continuous-glucose-measurements
#13
Katie M Kinnear, Nicole M Warner, Anand Gersappe, Michael J Doherty
Objectives: To match responsive neurostimulator (RNS) and polysomnographic data to determine if RNS detections and stimulations correlate with measurements of sleep disordered breathing and continuous glucose measurements (CGM). Materials and methods: In a patient with an RNS with detection/stimulation leads implanted bi-temporally detection-stimulation counts were matched by time with coinciding polysomnogram and CGM data. Results: Temporal dispersion of RNS DSC were independent of measures of sleep apnea, hypopnea or glucose...
2018: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/29688755/beyond-hba1c-comparing-glycemic-variability-and-glycemic-indices-in-predicting-hypoglycemia-in-type-1-and-type-2-diabetes
#14
Suresh Rama Chandran, Wei Lin Tay, Weng Kit Lye, Lee Ling Lim, Jeyakantha Ratnasingam, Alexander Tong Boon Tan, Daphne S L Gardner
BACKGROUND: Hypoglycemia is the major impediment to therapy intensification in diabetes. Although higher individualized HbA1c targets are perceived to reduce the risk of hypoglycemia in those at risk of hypoglycemia, HbA1c itself is a poor predictor of hypoglycemia. We assessed the use of glycemic variability (GV) and glycemic indices as independent predictors of hypoglycemia. METHODS: A retrospective observational study of 60 type 1 and 100 type 2 diabetes subjects...
April 24, 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29688508/effects-of-physicochemical-characteristics-of-feed-ingredients-on-the-apparent-total-tract-digestibility-of-energy-dry-matter-and-nutrients-by-growing-pigs
#15
D M D L Navarro, E M A M Bruininx, L de Jong, H H Stein
Effects of physicochemical characteristics of feed ingredients on DE and ME and apparent total tract digestibility (ATTD) of GE, DM, and nutrients were determined in growing pigs using ingredients with different ratios between insoluble dietary fiber (IDF) and soluble dietary fiber (SDF). Eighty growing barrows (BW: 48.41 ± 1.50 kg) were allotted to a randomized complete block design with 10 diets and 8 replicate pigs per diet. Dietary treatments included a corn-based diet, a wheat-based diet, a corn-soybean meal (SBM) diet, and 7 diets based on a mixture of the corn-SBM diet and canola meal, distillers dried grains with solubles (DDGS), corn germ meal (CGM), copra expellers, sugar beet pulp (SBP), synthetic cellulose, or pectin...
April 24, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29688349/cellexpress-a-comprehensive-microarray-based-cancer-cell-line-and-clinical-sample-gene-expression-analysis-online-system
#16
Yi-Fang Lee, Chien-Yueh Lee, Liang-Chuan Lai, Mong-Hsun Tsai, Tzu-Pin Lu, Eric Y Chuang
http://cellexpress.cgm.ntu.edu.tw/.
January 1, 2018: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/29687110/challenges-and-perspectives-in-continuous-glucose-monitoring
#17
Benjamin Jasha van Enter, Elizabeth von Hauff
Diabetes is a global epidemic that threatens the health and well-being of hundreds of millions of people. The first step in patient treatment is to monitor glucose levels. Currently this is most commonly done using enzymatic strips. This approach suffers from several limitations, namely it requires a blood sample and is therefore invasive, the quality and the stability of the enzymatic strips vary widely, and the patient is burdened by performing the measurement themselves. This results in dangerous fluctuations in glucose levels often going undetected...
April 24, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29681883/compromised-blood-brain-barrier-integrity-is-associated-with-total-magnetic-resonance-imaging-burden-of-cerebral-small-vessel-disease
#18
Yue Li, Man Li, Long Zuo, Qinglei Shi, Wei Qin, Lei Yang, Tao Jiang, Wenli Hu
Objective: Several studies have demonstrated that compromised blood-brain barrier (BBB) integrity may play a pivotal role in the pathogenesis of individual cerebral small vessel disease (cSVD) markers, but the association between BBB permeability and total magnetic resonance imaging (MRI) cSVD burden remains unclear. This study aimed to investigate the relationship between BBB permeability and total MRI cSVD burden. Methods: Consecutive participants without symptomatic stroke history presented for physical examination were enrolled in this cross-sectional study...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29681172/analyzing-the-potential-of-advanced-insulin-dosing-strategies-in-patients-with-type-2-diabetes-results-from-a-hybrid-in-silico-study
#19
Florian Reiterer, Matthias Reiter, Luigi Del Re, Merete Bechmann Christensen, Kirsten Nørgaard
BACKGROUND: The ongoing improvement of continuous glucose monitoring (CGM) sensors and of insulin pumps are paving the way for a fast implementation of artificial pancreas (AP) for type 1 diabetes (T1D) patients. The case for type 2 diabetes (T2D) patients is less obvious since usually some residual beta cell function allows for simpler therapy approaches, and even multiple daily injections (MDI) therapy is not very widespread. However, the number of insulin dependent T2D patients is vastly increasing and therefore a need for understanding chances and challenges of an automated insulin therapy arises...
April 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29674323/hemoglobin-a-1c-accurately-predicts-continuous-glucose-monitoring-derived-average-glucose-in-youth-and-young-adults-with-cystic-fibrosis
#20
Christine L Chan, Emma Hope, Jessica Thurston, Timothy Vigers, Laura Pyle, Philip S Zeitler, Kristen J Nadeau
OBJECTIVE: In cystic fibrosis (CF), HbA1c is thought to underestimate glycemia. However, few studies have directly assessed the relationship between HbA1c and average glucose in CF. We determined the relationships among glycemic markers-HbA1c , fructosamine (FA), glycated albumin (%GA), and 1,5-anhydroglucitol (1,5-AG)-and continuous glucose monitoring (CGM) in CF, hypothesizing that alternate markers would better predict average sensor glucose (ASG) than HbA1c . RESEARCH DESIGN AND METHODS: CF participants and a group of healthy control subjects (HC), ages 6-25 years, wore CGM for up to 7 days...
April 19, 2018: Diabetes Care
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