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https://www.readbyqxmd.com/read/28633537/extensive-assessment-of-blood-glucose-monitoring-during-postprandial-period-and-its-impact-on-closed-loop-performance
#1
Lyvia Biagi, Arthur Hirata Bertachi, Ignacio Conget, Carmen Quirós, Marga Giménez, F Javier Ampudia-Blasco, Paolo Rossetti, Jorge Bondia, Josep Vehí
BACKGROUND: Closed-loop (CL) systems aims to outperform usual treatments in blood glucose control and continuous glucose monitors (CGM) are a key component in such systems. Meals represents one of the main disturbances in blood glucose control, and postprandial period (PP) is a challenging situation for both CL system and CGM accuracy. METHODS: We performed an extensive analysis of sensor's performance by numerical accuracy and precision during PP, as well as its influence in blood glucose control under CL therapy...
June 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28628286/-contribution-of-continuous-glucose-measurement-in-the-management-of-gestational-diabetes-a-pilot-study
#2
M Franck, J-C Philips, P Emonts, R P Radermecker
The prevalence of gestational diabetes increases as a result of universal screening, but also because of more stringent diagnostic criteria due to decreased set points. This diabetes can lead to severe complications for the offspring and / or for the mother. The management of a patient suffering from gestational diabetes is based on healthy diet and lifestyle advices. Iterative control of capillary glycemia is the usual way to monitor daily blood glucose. Continuous blood glucose measurement (CGM) provides reliable and comprehensive data over several days...
June 2017: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28627250/exploring-the-frequency-domain-of-continuous-glucose-monitoring-signals-to-improve-characterization-of-glucose-variability-and-of-diabetic-profiles
#3
Giuseppe Fico, Liss Hernández, Jorge Cancela, Miguel María Isabel, Andrea Facchinetti, Chiara Fabris, Rafael Gabriel, Claudio Cobelli, María Teresa Arredondo Waldmeyer
BACKGROUND: Continuous glucose monitoring (CGM) devices measure interstitial glucose concentrations (normally every 5 minutes), allowing observation of glucose variability (GV) patterns during the whole day. This information could be used to improve prescription of treatments and of insulin dosages for people suffering diabetes. Previous efforts have been focused on proposing indices of GV either in time or glucose domains, while the frequency domain has been explored only partially. The aim of this work is to explore the CGM signal in the frequency domain to understand if new indexes or features could be identified and contribute to a better characterization of glucose variability...
January 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28627221/management-and-family-burdens-endorsed-by-parents-of-youth-7-years-old-with-type-1-diabetes
#4
Kara Harrington, Claire T Boyle, Kellee M Miller, Marisa E Hilliard, Barbara J Anderson, Michelle Van Name, Linda A DiMeglio, Lori M Laffel
BACKGROUND: This study investigated unique burdens experienced by parents of young children with type 1 diabetes in the context of contemporary diabetes management. METHODS: Self-report surveys and medical record information from the T1D Exchange clinic registry were used. Parental burden and family impact scores were tabulated across demographic and clinical characteristics, overall and according to age group (<4, 4-<6, and 6-<7 years). RESULTS: The mean age of the 549 children was 5...
February 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28625799/continuous-glucose-monitoring-in-a-cystic-fibrosis-patient-to-predict-pulmonary-exacerbation
#5
T B Inman, J A Proudfoot, M Lim, C Demeterco-Berggren
Patients with cystic fibrosis (CF) experience a significant decline in pulmonary status before the diagnosis of cystic fibrosis related diabetes (CFRD). We hypothesized that hyperglycemia may be a factor in the decline of pulmonary function and increased frequency of pulmonary exacerbations. Long term continuous glucose monitoring (CGM) has not been reported in patients with CF and impaired glucose tolerance. We performed CGM for three months in a 17year old male with F508del and F553X CF mutations, baseline forced expiratory volume in 1s (FEV1) of 92% predicted, and impaired glucose tolerance to evaluate changes in glucose levels prior to the diagnosis of a pulmonary exacerbation...
June 15, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/28625540/effects-of-breaking-up-sitting-on-adolescents-postprandial-glucose-after-consuming-meals-varying-in-energy-a-cross-over-randomised-trial
#6
Elly A Fletcher, Jo Salmon, Sarah A McNaughton, Liliana Orellana, Glenn D Wadley, Clinton Bruce, Paddy C Dempsey, Kathleen E Lacy, David W Dunstan
OBJECTIVES: To explore the impact of uninterrupted sitting versus sitting with resistance-type activity breaks on adolescents' postprandial glucose responses while consuming a diet varying in energy. DESIGN: Cross-over randomised trial. METHODS: Thirteen healthy participants (16.4±1.3years) completed a four-treatment cross-over trial: (1) uninterrupted sitting+high-energy diet; (2) sitting with breaks+high-energy diet; (3) uninterrupted sitting+standard-energy diet; and (4) sitting with breaks+standard-energy diet...
June 9, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28617628/pilot-study-of-a-novel-application-for-data-visualization-in-type-1-diabetes
#7
Jenise C Wong, Aaron B Neinstein, Howard Look, Brandon Arbiter, Nora Chokr, Cassie Ross, Saleh Adi
BACKGROUND: A novel software application, Blip, was created to combine and display diabetes data from multiple devices in a uniform, user-friendly manner. The objective of this study was to test the usability of this application by adults and caregivers of children with type 1 diabetes (T1D). METHODS: Patients (n = 35) and caregivers of children with T1D (n = 30) using an insulin pump for >1 year ± CGM were given access to the software for 3 months. Diabetes management practices and the use of diabetes data were assessed at baseline and at study end, and feedback was gathered in a concluding questionnaire...
February 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28617187/retrospective-analysis-of-continuous-glucose-monitoring-data-with-the-surveillance-error-grid-supports-nonadjunctive-dosing-decisions
#8
John B Welsh, Tomas Walker, David Price
OBJECTIVE: The objective was to assess clinical risks of inaccurate continuous glucose monitoring (CGM) system readings as estimated by the surveillance error grid (SEG). METHODS: Values from Dexcom G4 Platinum system with an advanced algorithm (Software 505) were plotted on the SEG with temporally matched reference venous (YSI) values collected during clinic visits on days 1, 4, and 7 of sensor wear. Data from a pediatric study (N = 79, age [mean ± SD] 12.2 ± 4...
February 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28616804/hypoglycemic-event-frequency-and-the-effect-of-continuous-glucose-monitoring-in-adults-with-type-1-diabetes-using-multiple-daily-insulin-injections
#9
Tonya Riddlesworth, David Price, Nathan Cohen, Roy W Beck
INTRODUCTION: The benefits of continuous glucose monitoring (CGM) in type 1 diabetes have been established among adults using insulin pumps. The DIAMOND randomized clinical trial examined the effectiveness of using CGM in improving glycemic control in participants using insulin injections. The frequency of hypoglycemic events in this trial has not been previously examined. METHODS: Adults with type 1 diabetes using multiple daily insulin injections (MDI) with A1C values of 7...
June 14, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28611921/adherence-of-self-monitoring-of-blood-glucose-in-persons-with-type-1-diabetes-in-sweden
#10
Peter Moström, Elsa Ahlén, Henrik Imberg, Per-Olof Hansson, Marcus Lind
OBJECTIVE: The primary aim was to evaluate the extent to which persons with type 1 diabetes perform self-monitoring of blood glucose (SMBG) according to guidelines. Secondary objectives were to investigate predictors for good SMBG adherence, reasons for non-adherence, and association between SMBG frequency and hemoglobin A1c (HbA1c). METHODS: This was a survey-based cross-sectional study. Questionnaires were sent out to 600 random patients at five sites. Patients were included if they were diagnosed with type 1 diabetes and ≥18 years old and excluded if they were currently using continuous glucose monitoring (CGM)...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28608489/continuous-glucose-monitoring-following-pancreatectomy-with-islet-autotransplantation-in-children
#11
Deborah A Elder, Jose M Jiminez-Vega, Lindsey N Hornung, Ranjit S Chima, Maisam Abu-El-Haija, Tom K Lin, Joseph J Palermo, Jaimie D Nathan
Aim was to determine whether CGM could accurately monitor blood glucose concentration in the immediate postoperative period following pancreatectomy with IAT in children. CGM was used in nine patients undergoing IAT at our institution between April 2015 and September 2016 (eight total pancreatectomy and one subtotal pancreatectomy). MAD and MARD of CGM values compared to time-matched serum blood glucose were calculated during the first 5 days of ICU admission. Goal range was defined as 70-140 mg/dL and out-of-range was >140 mg/dL or <70 mg/dL...
June 12, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28605286/the-durability-of-basal-insulin-affects-day-to-day-glycemic-variability-assessed-by-continuous-glucose-monitoring-in-type-2-diabetes-patients-a-randomized-crossover-trial
#12
Hiroyuki Iuchi, Masaya Sakamoto, Daisuke Matsutani, Hirofumi Suzuki, Ryuzo Horiuchi, Kazunori Utsunomiya
BACKGROUND: Not only within-day glycemic variability but also day-to-day glycemic variability is a risk factor for diabetic patients. However, the ways of controlling day-to-day glycemic variability are unclear. We hypothesized that the durability of basal insulin plays an important role in controlling day-to-day glycemic variability in type 2 diabetes patients, and we therefore aimed to evaluate whether glargine U300, which exhibits prolonged absorption compared with glargine U100 but the same composition as glargine U100, would lead to improved day-to-day glycemic variability...
June 12, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28604634/modeling-the-error-of-the-medtronic-paradigm-veo-enlite-glucose-sensor
#13
Lyvia Biagi, Charrise M Ramkissoon, Andrea Facchinetti, Yenny Leal, Josep Vehi
Continuous glucose monitors (CGMs) are prone to inaccuracy due to time lags, sensor drift, calibration errors, and measurement noise. The aim of this study is to derive the model of the error of the second generation Medtronic Paradigm Veo Enlite (ENL) sensor and compare it with the Dexcom SEVEN PLUS (7P), G4 PLATINUM (G4P), and advanced G4 for Artificial Pancreas studies (G4AP) systems. An enhanced methodology to a previously employed technique was utilized to dissect the sensor error into several components...
June 12, 2017: Sensors
https://www.readbyqxmd.com/read/28602020/techniques-of-monitoring-blood-glucose-during-pregnancy-for-women-with-pre-existing-diabetes
#14
REVIEW
Foong Ming Moy, Amita Ray, Brian S Buckley, Helen M West
BACKGROUND: Self-monitoring of blood glucose (SMBG) is recommended as a key component of the management plan for diabetes therapy during pregnancy. No existing systematic reviews consider the benefits/effectiveness of various techniques of blood glucose monitoring on maternal and infant outcomes among pregnant women with pre-existing diabetes. The effectiveness of the various monitoring techniques is unclear. OBJECTIVES: To compare techniques of blood glucose monitoring and their impact on maternal and infant outcomes among pregnant women with pre-existing diabetes...
June 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28601374/quantitative-susceptibility-mapping-qsm-and-r2-in-the-human-brain-at-3t-evaluation-of-intra-scanner-repeatability
#15
Xiang Feng, Andreas Deistung, Jürgen R Reichenbach
Quantitative susceptibility mapping (QSM) and the effective transverse relaxation rate (R2*) can be used to monitor iron and myelin content in brain tissue, which are both subject to changes in many neurological diseases but also during healthy aging. In this study, we quantitatively assessed the repeatability of QSM and R2* by applying four independent scans in eight young healthy, female subjects on a 3T MRI scanner. Since QSM does not yield absolute values for bulk magnetic susceptibilities, we additionally investigated the influence of the choice of a reference brain region for susceptibility by computing susceptibility differences with respect to five different brain structures (whole brain, frontal white matter (fWM), internal capsule (IC), cerebrospinal fluid (CSF) in the lateral ventricle, cortical gray matter (cGM))...
June 7, 2017: Zeitschrift Für Medizinische Physik
https://www.readbyqxmd.com/read/28592737/octreotide-lar-was-useful-for-avoiding-hypoglycemia-in-an-elderly-patient-with-insulinoma
#16
Ayaka Kanno, Kana Ide, Kenichi Kurita, Takashi Terano, Kyohei Yamamoto
An 80-year-old woman was admitted to our hospital with a hypoglycemia attack. She was diagnosed with insulinoma based on her high insulin level at the time of the hypoglycemia attack and the presence of a hypervascular tumor in her pancreas. The patient refused surgical treatment and octreotide was used to prevent hypoglycemia.It is known that octreotide suppresses the secretion of insulin from the pancreas; however, insulin secretion is not always suppressed in patients with insulinoma. Moreover, there is no particular protocol for the use of octreotide in the treatment of insulinoma...
2017: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/28591776/efficacy-and-safety-of-mini-dose-glucagon-for-treatment-of-non-severe-hypoglycemia-in-adults-with-type-1-diabetes
#17
Morey W Haymond, Stephanie N DuBose, Michael R Rickels, Howard Wolpert, Viral N Shah, Jennifer L Sherr, Ruth S Weinstock, Shivani Agarwal, Alandra S Verdejo, Martin J Cummins, Brett Newswanger, Roy W Beck
Context: Standard treatment for hypoglycemia is oral carbohydrate, but often results in hyperglycemia and requires extra caloric intake. Objective: To evaluate the use of low-dose glucagon to treat mild hypoglycemia in ambulatory adults with type 1 diabetes (T1D). Design: Randomized crossover trial (two 3-week periods). Setting: Five U.S. diabetes clinics. Patients: Twenty adults with T1D using an insulin pump and continuous glucose monitor (CGM) and experiencing frequent mild hypoglycemia...
June 7, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28585879/continuous-glucose-monitoring-a-review-of-recent-studies-demonstrating-improved-glycemic-outcomes
#18
David Rodbard
Continuous Glucose Monitoring (CGM) has been demonstrated to be clinically valuable, reducing risks of hypoglycemia and hyperglycemia, glycemic variability (GV), and improving patient quality of life for a wide range of patient populations and clinical indications. Use of CGM can help reduce HbA1c and mean glucose. One CGM device, with accuracy (%MARD) of approximately 10%, has recently been approved for self-adjustment of insulin dosages (nonadjuvant use) and approved for reimbursement for therapeutic use in the United States...
June 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28585878/practical-considerations-on-the-use-of-continuous-glucose-monitoring-in-pediatrics-and-older-adults-and-nonadjunctive-use
#19
Gregory P Forlenza, Nicholas B Argento, Lori M Laffel
Clinical use of continuous glucose monitoring (CGM) devices has grown over the past 15 years from a niche concept to becoming standard of care for patients with type 1 diabetes (T1D). With the December 2016 Food and Drug Administration approval for diabetes treatment decisions directly from CGM values (nonadjunctive use) without finger-stick confirmation, the uptake and scope of CGM use will likely further expand. With this expansion, it is important to consider the role and impact of CGM technology in specific settings and high-risk populations, such as the young and the elderly...
June 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28585877/future-of-automated-insulin-delivery-systems
#20
Jessica R Castle, J Hans DeVries, Boris Kovatchev
Advances in continuous glucose monitoring (CGM) have brought on a paradigm shift in the management of type 1 diabetes. These advances have enabled the automation of insulin delivery, where an algorithm determines the insulin delivery rate in response to the CGM values. There are multiple automated insulin delivery (AID) systems in development. A system that automates basal insulin delivery has already received Food and Drug Administration approval, and more systems are likely to follow. As the field of AID matures, future systems may incorporate additional hormones and/or multiple inputs, such as activity level...
June 2017: Diabetes Technology & Therapeutics
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