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case files of the Massachusetts

Julie Guilmette, Gunnlaugur P Nielsen, William C Faquin, Martin Selig, Vânia Nosé, Anthony W S Chi, Peter M Sadow
Mammary analogue secretory carcinoma (MASC) of the salivary glands is a recently described neoplasm of the salivary glands with a characteristic morphology complemented by a specific cytogenetic translocation and gene rearrangements. Although immunophenotypic and cytogenetic differences allow for a more reliable distinction, ultrastructural features can also provide important information about the relationship between MASC, classic acinic cell carcinoma (AciCC), and AciCC intercalated duct cell-predominant variant...
December 2017: Head and Neck Pathology
Stephanie D Grabitz, Hassan N Farhan, Katarina J Ruscic, Fanny P Timm, Christina H Shin, Tharusan Thevathasan, Anne K Staehr-Rye, Tobias Kurth, Matthias Eikermann
OBJECTIVES: Inhalational anesthetics are bronchodilators with immunomodulatory effects. We sought to determine the effect of inhalational anesthetic dose on risk of severe postoperative respiratory complications. DESIGN: Prospective analysis of data on file in surgical cases between January 2007 and December 2015. SETTING: Massachusetts General Hospital (tertiary referral center) and two affiliated community hospitals. PATIENTS: A total of 124,497 adult patients (105,267 in the study cohort and 19,230 in the validation cohort) undergoing noncardiac surgical procedures and requiring general anesthesia with endotracheal intubation...
January 2017: Critical Care Medicine
Eike Hamad, Kavita Babu, Vikhyat S Bebarta
Cyanide toxicity is common after significant smoke inhalation. Two cases are presented that provide framework for the discussion of epidemiology, pathogenesis, presenting signs and symptoms, and treatment options of inhalational cyanide poisoning. An evidence-based algorithm is proposed that utilizes point-of-care testing to help physicians identify patients who benefit most from antidotal therapy.
June 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
Katherine L Boyle, Christopher D Rosenbaum
No abstract text is available yet for this article.
September 2014: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
Gordon D Schiff, Ann Louise Puopolo, Anne Huben-Kearney, Winnie Yu, Carol Keohane, Peggy McDonough, Bonnie R Ellis, David W Bates, Madeleine Biondolillo
IMPORTANCE: Despite prior focus on high-impact inpatient cases, there are increasing data and awareness that malpractice in the outpatient setting, particularly in primary care, is a leading contributor to malpractice risk and claims. OBJECTIVE: To study patterns of primary care malpractice types, causes, and outcomes as part of a Massachusetts ambulatory malpractice risk and safety improvement project. DESIGN, SETTING, AND PARTICIPANTS: Retrospective review of pooled closed claims data of 2 malpractice carriers covering most Massachusetts physicians during a 5-year period (January 1, 2005, through December 31, 2009)...
December 9, 2013: JAMA Internal Medicine
Katherine L Boyle, Christopher D Rosenbaum
No abstract text is available yet for this article.
June 2013: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
Mary K Barger, Angela Nannini, Susan DeJoy, Kirsten Wisner, Glenn Markenson
OBJECTIVE: To compare outcomes from uterine ruptures (UR) among women without versus with a prior cesarean. METHOD: This case-control study matched on gestational age +/- 1 week and birth year +/- 2 years using a variable numbers of controls (maximum = 4) for each case. All URs in Massachusetts between 1990 and 1998 were identified using ICD-9 codes from linked hospital discharge and birth/fetal death certificate files and confirmed by medical record review. Complete hospitalization records were abstracted...
January 2013: Journal of Maternal-fetal & Neonatal Medicine
Matthew D Zuckerman, Katherine L Boyle, Christopher D Rosenbaum
No abstract text is available yet for this article.
September 2012: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
Ricard Masia, Daniel S Pratt, Joseph Misdraji
CONTEXT: Hepatotoxicity is an important side effect of thiopurine analog treatment for inflammatory bowel disease. A variety of histopathologic findings have been observed in patients with inflammatory bowel disease with thiopurine-induced hepatotoxicity, including nodular regenerative hyperplasia, vascular injury, and cholestasis. OBJECTIVE: To describe the histologic features shared by 3 cases of thiopurine-induced hepatotoxicity in patients with inflammatory bowel disease...
June 2012: Archives of Pathology & Laboratory Medicine
M K Barger, A Nannini, J Weiss, E R Declercq, P Stubblefield, M Werler, S Ringer
OBJECTIVE: To describe maternal and perinatal morbidity and mortality associated with uterine rupture (UR) among women with prior cesarean/s, singleton term pregnancies and a trial of labor after cesarean (TOLAC). STUDY DESIGN: Linked hospital discharge files and birth/fetal death certificates identified potential cases of UR in Massachusetts from 1990 to 1998 with definitive identification by medical record abstraction. RESULT: Among the 347 identified URs, severe outcomes occurred in 86 cases (25%), in 49 (14%) of mothers and 49 (14%) of infants...
November 2012: Journal of Perinatology: Official Journal of the California Perinatal Association
Jason E Frangos, Lyn M Duncan, Adriano Piris, Rosalynn M Nazarian, Martin C Mihm, Mai P Hoang, Briana Gleason, Thomas J Flotte, Hugh R Byers, Raymond L Barnhill, Alexa B Kimball
BACKGROUND: Diagnostic practice by dermatopathologists evaluating pigmented lesions may have evolved over time. OBJECTIVES: We sought to investigate diagnostic drift among a group of dermatopathologists asked to re-evaluate cases initially diagnosed 20 years ago. METHODS: Twenty nine cases of dysplastic nevi with severe atypia and 11 cases of thin radial growth-phase melanoma from 1988 through 1990 were retrieved from the pathology files of the Massachusetts General Hospital...
September 2012: Journal of the American Academy of Dermatology
Joseph Misdraji, Nancy Lee Harris, Robert P Hasserjian, Gregory Y Lauwers, Judith A Ferry
BACKGROUND: Follicular lymphoma (FL), a common nodal lymphoma, is rare in the gastrointestinal (GI) tract. We report our experience with primary FL of the GI tract. METHODS: The surgical pathology computer files at the Massachusetts General Hospital were searched for cases of FL involving the GI tract. Patients were included if on staging, the major site of disease was the GI tract. Thirty-nine cases were identified. Clinical data were collected from electronic medical records...
September 2011: American Journal of Surgical Pathology
Rosalynn M Nazarian, Rajni V Mandal, Anna Kagan, Jonathan Kay, Lyn M Duncan
BACKGROUND: Nephrogenic systemic fibrosis (NSF) affects patients with impaired renal function who have received gadolinium-containing contrast agents (GCCAs). Increased dermal cellularity is a key diagnostic feature of NSF, however, the histologic findings can be subtle. OBJECTIVE: We sought to determine whether dermal cellularity in skin biopsy specimens from NSF cases: (1) differs significantly from that of controls; and (2) correlates with duration of the skin lesions, level of plasma creatinine, GCCA dose, or a combination of these...
April 2011: Journal of the American Academy of Dermatology
Aaron S Kesselheim, Martin T November, Karen L Lifford, Thomas F McElrath, Ann L Puopolo, E John Orav, David M Studdert
RATIONALE, AIMS AND OBJECTIVES: We sought to use a novel case-selection methodology to identify antenatal or intrapartum risk factors associated with neonatal neurological impairment following non-reassuring fetal heart rate patterns during labour. METHOD: We used a retrospective case-control design with bivariate and multivariate conditional logistic regression. Cases were births in which electronic fetal monitoring (EFM) showed non-reassuring patterns and the infant had neurological disability...
June 2010: Journal of Evaluation in Clinical Practice
Sejal S Shah, William C Faquin, Roberto Izquierdo, Kamal K Khurana
BACKGROUND: Fine needle aspiration (FNA) cytology is a popular, reliable and cost effective technique for the diagnosis of thyroid lesions. The aim of our study was to review cases of misclassified primary malignant neoplasms of the thyroid by FNA, and assess the causes of cytologic misdiagnosis and their impact on clinical management. METHODS: Clinical data, FNA smears and follow-up surgical specimens of cases diagnosed with primary thyroid carcinoma were reviewed...
2009: CytoJournal
Richard J Church, Edward W Boyer
No abstract text is available yet for this article.
March 2009: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
Carlos Aitor Macias, Matthew R Rosengart, Juan-Carlos Puyana, Walter T Linde-Zwirble, Wade Smith, Andrew B Peitzman, Derek C Angus
OBJECTIVE: To evaluate compliance with American College of Surgeons (ACS) guidelines and whether trauma center designation, hospital traumatic spinal cord injury (TSCI) case volume or spinal surgery volume is associated with paralysis. We hypothesized a priori that trauma center care, by contrast to nontrauma center care, is associated with reduced paralysis at discharge. SUMMARY BACKGROUND DATA: Approximately 11,000 persons incur a TSCI in the United States annually...
January 2009: Annals of Surgery
Barbara S Webster, Manuel Cifuentes, Santosh Verma, Glenn Pransky
BACKGROUND: Given reports about variation in opioid prescribing, concerns about increasing opioid use and its associated negative consequences make understanding the sources of variability important. The aims of the study were to assess the extent of and factors associated with geographic variation in early opioid prescribing for acute, work-related, low back pain (LBP). METHODS: Cases were selected from workers compensation administrative data filed between January 1, 2002 and December 31, 2003 and included claims from states with more than 40 cases...
February 2009: American Journal of Industrial Medicine
James Courtney, Edward Boyer
UNLABELLED: A 67 year-old male presented to the emergency department with alteration in mental status. On arrival he had vital signs: pulse 110, BP 173/83, respiratory rate 4, oxygen saturation 57% and temperature 36.1 degrees Celsius. His past medical history included hypertension, vitamin B12 deficiency, hyperlipidemia, and recurrent cellulitis treated with vancomycin. The patient had no response to noxious stimuli, pinpoint pupils, and agonal respirations. Secondary to his wife's vehement denial that he had access to or history of using any narcotics, he was intubated after 2...
September 2008: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
Christina Hernon, Edward W Boyer, Doran Christensen, Steve Sugarman
No abstract text is available yet for this article.
December 2006: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
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