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Iole Cordone, Serena Masi, Mariantonia Carosi, Antonello Vidiri, Francesco Marchesi, Mirella Marino, Stefano Telera, Alessia Pasquale, Andrea Mengarelli, Laura Conti, Edoardo Pescarmona, Andrea Pace, Carmine M Carapella
BACKGROUND: Brain stereotactic biopsy (SB) followed by conventional histopathology and immunohistochemistry (IHC) is the gold standard approach for primary central nervous system lymphoma (PCNSL) diagnosis. Flow cytometry (FCM) characterization of fine-needle aspiration cytology and core needle biopsies are increasingly utilized to diagnose lymphomas however, no biological data have been published on FCM characterization of fresh single cell suspension from PCNSL SB. The aim of this study was to establish the feasibility and utility of FCM for the diagnosis and characterization of brain lymphomas from a tissue samples obtained by a single SB disaggregation...
2016: Journal of Experimental & Clinical Cancer Research: CR
Claudio Babiloni, Alfredo Pennica, Claudio Del Percio, Giuseppe Noce, Susanna Cordone, Susanna Lopez, Ketura Berry, Chiara Muratori, Stefano Ferracuti, Paolo Roma, Valentina Correr, Francesco Di Campli, Laura Gianserra, Lorenzo Ciullini, Antonio Aceti, Andrea Soricelli, Elisabetta Teti, Magdalena Viscione, Cristina Limatola, Paolo Onorati, Paolo Capotosto, Massimo Andreoni
OBJECTIVE: Here we tested the effect of combined antiretroviral therapy (cART) on deviant electroencephalographic (EEG) source activity in treatment-naïve HIV individuals. METHODS: Resting state eyes-closed EEG data were recorded before and after 5 months of cART in 48 male HIV subjects, who were naïve at the study start. The EEG data were also recorded in 59 age- and sex-matched healthy subjects as a control group. Frequency bands of interest included delta, theta, alpha1, alpha2 and alpha3, based on alpha frequency peak specific to each individual...
2016: NeuroImage: Clinical
Claudio Babiloni, Antonio I Triggiani, Roberta Lizio, Susanna Cordone, Giacomo Tattoli, Vitoantonio Bevilacqua, Andrea Soricelli, Raffaele Ferri, Flavio Nobili, Loreto Gesualdo, José C Millán-Calenti, Ana Buján, Rosanna Tortelli, Valentina Cardinali, Maria Rosaria Barulli, Antonio Giannini, Pantaleo Spagnolo, Silvia Armenise, Grazia Buenza, Gaetano Scianatico, Giancarlo Logroscino, Giovanni B Frisoni, Claudio Del Percio
Previous studies have shown abnormal power and functional connectivity of resting state electroencephalographic (EEG) rhythms in groups of Alzheimer's disease (AD) compared to healthy elderly (Nold) subjects. Here we tested the best classification rate of 120 AD patients and 100 matched Nold subjects using EEG markers based on cortical sources of power and functional connectivity of these rhythms. EEG data were recorded during resting state eyes-closed condition. Exact low-resolution brain electromagnetic tomography (eLORETA) estimated the power and functional connectivity of cortical sources in frontal, central, parietal, occipital, temporal, and limbic regions...
2016: Frontiers in Neuroscience
Claudio Babiloni, Alfredo Pennica, Claudio Del Percio, Giuseppe Noce, Susanna Cordone, Chiara Muratori, Stefano Ferracuti, Nicole Donato, Francesco Di Campli, Laura Gianserra, Elisabetta Teti, Antonio Aceti, Andrea Soricelli, Magdalena Viscione, Cristina Limatola, Massimo Andreoni, Paolo Onorati
OBJECTIVE: This study tested a simple statistical procedure to recognize single treatment-naïve HIV individuals having abnormal cortical sources of resting state delta (<4 Hz) and alpha (8-13 Hz) electroencephalographic (EEG) rhythms with reference to a control group of sex-, age-, and education-matched healthy individuals. Compared to the HIV individuals with a statistically normal EEG marker, those with abnormal values were expected to show worse cognitive status. METHODS: Resting state eyes-closed EEG data were recorded in 82 treatment-naïve HIV (39...
March 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Nathan E Grega-Larson, Scott W Crawley, Amanda L Erwin, Matthew J Tyska
Microvilli are actin-based protrusions found on the surface of diverse cell types, where they amplify membrane area and mediate interactions with the external environment. In the intestinal tract, these protrusions play central roles in nutrient absorption and host defense and are therefore essential for maintaining homeostasis. However, the mechanisms controlling microvillar assembly remain poorly understood. Here we report that the multifunctional actin regulator cordon bleu (COBL) promotes the growth of brush border (BB) microvilli...
November 1, 2015: Molecular Biology of the Cell
Pamela M Pennington, Louisa Alexandra Messenger, Jeffrey Reina, José G Juárez, Gena G Lawrence, Ellen M Dotson, Martin S Llewellyn, Celia Cordón-Rosales
Parasites transmitted by insects must adapt to their vectors and reservoirs. Chagas disease, an American zoonosis caused by Trypanosoma cruzi, is transmitted by several species of triatomines. In Central America, Triatoma dimidiata is a widely dispersed vector found in sylvatic and domestic habitats, with distinct populations across the endemic region of Guatemala. Our aim was to test the strength of association between vector and parasite genetic divergence in domestic environments. Microsatellite (MS) loci were used to characterize parasites isolated from T...
November 2015: Acta Tropica
E N I Weeks, C Davies, C Cordón Rosales, M Yeo, S A Gezan, G Parra-Henao, M M Cameron
In Guatemala, the most widespread vector of Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae), the causative agent of Chagas disease, is Triatoma dimidiata (Latreille) (Hemiptera: Reduviidae: Triatominae). T. dimidiata is native to Guatemala and is present in both domestic and sylvatic habitats. Consequently, control of T. dimidiata is difficult because after successful elimination from homes, individual insects can recolonize homes from the surrounding environment. Therefore, intensive long-term surveillance of this species is essential to ensure adequate control is achieved...
September 2014: Journal of Medical Entomology
Jessica Wayt, Anthony Bretscher
Cordon Bleu (Cobl) is a WH2-containing protein believed to act as an actin nucleator. We show that it has a very specific localization in epithelial cells at the basal region of microvilli, a localization unlikely to be involved in actin nucleation. The protein is localized by a central region between the N-terminal COBL domain and the three C-terminal WH2 domains. Ectopic expression of Cobl shortens apical microvilli, and this requires functional WH2 domains. Proteomic studies reveal that the COBL domain binds several BAR-containing proteins, including SNX9, PACSIN 2/syndapin 2, and ASAP1...
September 15, 2014: Molecular Biology of the Cell
Carlos Cordon-Obras, Jorge Cano, Jenny Knapp, Paloma Nebreda, Nicolas Ndong-Mabale, Policarpo Ricardo Ncogo-Ada, Pedro Ndongo-Asumu, Miguel Navarro, Joao Pinto, Agustin Benito, Jean-Mathieu Bart
BACKGROUND: Luba is one of the four historical foci of Human African Trypanosomiasis (HAT) on Bioko Island, in Equatorial Guinea. Although no human cases have been detected since 1995, T. b. gambiense was recently observed in the vector Glossina palpalis palpalis. The existence of cryptic species within this vector taxon has been previously suggested, although no data are available regarding the evolutionary history of tsetse flies populations in Bioko. METHODS: A phylogenetic analysis of 60 G...
2014: Parasites & Vectors
Manuel Nieves-Cordones, Alain Chavanieu, Linda Jeanguenin, Carine Alcon, Wojciech Szponarski, Sebastien Estaran, Isabelle Chérel, Sabine Zimmermann, Hervé Sentenac, Isabelle Gaillard
Shaker K(+) channels form the major K(+) conductance of the plasma membrane in plants. They are composed of four subunits arranged around a central ion-conducting pore. The intracellular carboxy-terminal region of each subunit contains several regulatory elements, including a C-linker region and a cyclic nucleotide-binding domain (CNBD). The C-linker is the first domain present downstream of the sixth transmembrane segment and connects the CNBD to the transmembrane core. With the aim of identifying the role of the C-linker in the Shaker channel properties, we performed subdomain swapping between the C-linker of two Arabidopsis (Arabidopsis thaliana) Shaker subunits, K(+) channel in Arabidopsis thaliana2 (KAT2) and Arabidopsis thaliana K(+) rectifying channel1 (AtKC1)...
March 2014: Plant Physiology
Cristina Sánchez-Fernández, Ángeles Montilla-García, Rafael González-Cano, Francisco Rafael Nieto, Lucía Romero, Antonia Artacho-Cordón, Rosa Montes, Begoña Fernández-Pastor, Manuel Merlos, José Manuel Baeyens, José Manuel Entrena, Enrique José Cobos
We evaluated the effects of σ1-receptor inhibition on μ-opioid-induced mechanical antinociception and constipation. σ1-Knockout mice exhibited marked mechanical antinociception in response to several μ-opioid analgesics (fentanyl, oxycodone, morphine, buprenorphine, and tramadol) at systemic (subcutaneous) doses that were inactive in wild-type mice and even unmasked the antinociceptive effects of the peripheral μ-opioid agonist loperamide. Likewise, systemic (subcutaneous) or local (intraplantar) treatment of wild-type mice with the selective σ1 antagonists BD-1063 [1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine dihydrochloride] or S1RA [4-[2-[[5-methyl-1-(2-naphthalenyl)1H-pyrazol-3-yl]oxy]ethyl] morpholine hydrochloride] potentiated μ-opioid antinociception; these effects were fully reversed by the σ1 agonist PRE-084 [2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate) hydrochloride], showing the selectivity of the pharmacological approach...
January 2014: Journal of Pharmacology and Experimental Therapeutics
Fernando A Monteiro, Tatiana Peretolchina, Cristiano Lazoski, Kecia Harris, Ellen M Dotson, Fernando Abad-Franch, Elsa Tamayo, Pamela M Pennington, Carlota Monroy, Celia Cordon-Rosales, Paz Maria Salazar-Schettino, Andrés Gómez-Palacio, Mario J Grijalva, Charles B Beard, Paula L Marcet
BACKGROUND: Triatoma dimidiata is among the main vectors of Chagas disease in Latin America. However, and despite important advances, there is no consensus about the taxonomic status of phenotypically divergent T. dimidiata populations, which in most recent papers are regarded as subspecies. METHODOLOGY AND FINDINGS: A total of 126 cyt b sequences (621 bp long) were produced for specimens from across the species range. Forty-seven selected specimens representing the main cyt b clades observed (after a preliminary phylogenetic analysis) were also sequenced for an ND4 fragment (554 bp long) and concatenated with their respective cyt b sequences to produce a combined data set totalling 1175 bp/individual...
2013: PloS One
Richard D Johnston, Mary C Stephenson, Hannah Crossland, Sally M Cordon, Elisa Palcidi, Eleanor F Cox, Moira A Taylor, Guruprasad P Aithal, Ian A Macdonald
BACKGROUND & AIMS: Diets high in fructose have been proposed to contribute to nonalcoholic fatty liver disease. We compared the effects of high-fructose and matched glucose intake on hepatic triacylglycerol (TAG) concentration and other liver parameters. DESIGN: In a double-blind study, we randomly assigned 32 healthy but centrally overweight men to groups that received either a high-fructose or high-glucose diet (25% energy). These diets were provided during an initial isocaloric period of 2 weeks, followed by a 6-week washout period, and then again during a hypercaloric 2-week period...
November 2013: Gastroenterology
Isabel Cordones, Carlos M Gómez, Miguel Escudero
To compare the cortical dynamics of different oculomotor tasks, EEG and eye movements were recorded in 21 volunteers. Using a comprehensive approach, subjects were asked to perform saccadic tasks, which included a saccadic eye movement to a peripheral target (prosaccadic), a movement to the opposite side (antisaccadic), or maintain the gaze fixed (no-go). In mixed trials, prosaccadic, antisaccadic and no-go tasks were indicated by a color square (S1) present for 1900-2500 ms (instructive period). S1 disappeared for 370 ms (gap) and a black dot at 8 deg at right or left indicated the beginning of the task...
2013: PloS One
Tinatin Zurashvili, Lluís Cordón-Barris, Gerard Ruiz-Babot, Xiangyu Zhou, Jose M Lizcano, Nestor Gómez, Lydia Giménez-Llort, Jose R Bayascas
3-Phosphoinositide-dependent protein kinase 1 (PDK1) operates in cells in response to phosphoinositide 3-kinase activation and phosphatidylinositol-3,4,5-trisphosphate [PtdIns(3,4,5)P(3)] production by activating a number of AGC kinases, including protein kinase B (PKB)/Akt. Both PDK1 and PKB contain pleckstrin homology (PH) domains that interact with the PtdIns(3,4,5)P(3) second messenger. Disrupting the interaction of the PDK1 PH domain with phosphoinositides by expressing the PDK1 K465E knock-in mutation resulted in mice with reduced PKB activation...
March 2013: Molecular and Cellular Biology
Federico A Zumaya-Estrada, Louisa A Messenger, Teresa Lopez-Ordonez, Michael D Lewis, Carlos A Flores-Lopez, Alejandro J Martínez-Ibarra, Pamela M Pennington, Celia Cordon-Rosales, Hernan V Carrasco, Maikel Segovia, Michael A Miles, Martin S Llewellyn
BACKGROUND: Trypanosoma cruzi, the agent of Chagas disease, is currently recognized as a complex of six lineages or Discrete Typing Units (DTU): TcI-TcVI. Recent studies have identified a divergent group within TcI - TcI(DOM). TcI(DOM). is associated with a significant proportion of human TcI infections in South America, largely absent from local wild mammals and vectors, yet closely related to sylvatic strains in North/Central America. Our aim was to examine hypotheses describing the origin of the TcI(DOM) genotype...
2012: Parasites & Vectors
David Martínez-Cuadrón, Pau Montesinos, Mariluz Pérez-Sirvent, Amparo Avaria, Lourdes Cordón, Rebeca Rodríguez-Veiga, Guillermo Martín, Jaime Sanz, Jesús Martínez, Miguel A Sanz
The risk factors for and incidence of central nervous system involvement at first relapse in adult patients with acute myeloid leukemia have not been established. This single-center study analyzed the prognostic factors for and cumulative incidence of meningeal relapse in 458 adult patients achieving complete remission. Before 1990, patients received old chemotherapy approaches without stem cell transplantation that often included prophylactic intrathecal chemotherapy. Since 1990, modern protocols included stem cell transplantation without intrathecal prophylaxis...
September 2011: Haematologica
Raymond J King, Celia Cordon-Rosales, Jonathan Cox, Clive R Davies, Uriel D Kitron
BACKGROUND: Guatemala is presently engaged in the Central America Initiative to interrupt Chagas disease transmission by reducing intradomiciliary prevalence of Triatoma dimidiata, using targeted cross-sectional surveys to direct control measures to villages exceeding the 5% control threshold. The use of targeted surveys to guide disease control programs has not been evaluated. Here, we compare the findings from the targeted surveys to concurrent random cross-sectional surveys in two primary foci of Chagas disease transmission in central and southeastern Guatemala...
2011: PLoS Neglected Tropical Diseases
José Lorenzo Romero-Trevejo, José Carlos Gómez-Villamandos, Miriam Pedrera, Alfonso Blanco, María José Bautista, Pedro José Sánchez-Cordón
To study numerical changes in intestinal macrophages and variations in cytokine production by immune cells in the intestine, conventional C57BL/6J mice were orally infected with the Rocky Mountain Laboratory strain of scrapie. Animals were sacrificed at different timepoints, and samples were taken and processed by routine methods for morphological and immunohistochemical analysis. The results point to a possible role for macrophages in the uptake and transport of the infective agent to Peyer's patches. The observed increase in macrophage numbers in subepithelial sites, taken in conjunction with a drop in tumour necrosis factor-alpha production at these sites, suggests a possible secretory inhibition that could be induced by the disease-associated prion protein (PrPd)...
August 2010: Histology and Histopathology
Carlos Cordon-Obras, Carmen García-Estébanez, Nicolás Ndong-Mabale, Simón Abaga, Pedro Ndongo-Asumu, Agustín Benito, Jorge Cano
BACKGROUND: Sleeping sickness is spread over 36 Sub-Saharan African countries. In West and Central Africa, the disease is caused by Trypanosoma brucei gambiense, which produces a chronic clinical manifestation. The Luba focus (Bioko Island, Equatorial Guinea) has not reported autochthonous sleeping sickness cases since 1995, but given the complexity of the epidemiological cycle, the elimination of the parasite in the environment is difficult to categorically ensure. METHODOLOGY/PRINCIPAL FINDINGS: The aim of this work is to assess, by a molecular approach (Polymerase Chain Reaction, PCR), the possible permanence of T...
2010: PLoS Neglected Tropical Diseases
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