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https://www.readbyqxmd.com/read/29471523/liver-transcriptomic-and-plasma-metabolomic-profiles-of-fattening-lambs-are-modified-by-feed-restriction-during-the-suckling-period
#1
A Santos, F J Giráldez, E Trevisi, L Lucini, J Frutos, S Andrés
The increasing world population is driving demand for improved efficiency of feed resources of livestock. However, the molecular mechanisms behind various feed efficiency traits and their regulation by nutrition remain poorly understood. Here we aimed to identify differentially expressed (DE) genes in the liver tissues of fattening Merino lambs and differences in metabolites accumulated in plasma to identify modified metabolic pathways as a consequence of milk restriction during the suckling period. Twenty-four male Merino lambs (4...
February 19, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29471417/a-study-of-circulating-micrornas-identifies-a-new-potential-biomarker-panel-to-distinguish-aggressive-prostate-cancer
#2
Batoul Farran, Gregory Dyson, Douglas Craig, Alan Dombkowski, Jennifer L Beebe-Dimmer, Isaac J Powell, Izabela Podgorski, Lance Heilbrun, Susan Bolton, Cathryn H Bock
Prostate cancer is one of the most common cancers in men worldwide. Currently available diagnostic and prognostic tools for this disease, such as PSA, suffer from lack of specificity and sensitivity, resulting in over- and misdiagnosis. Hence, there is an urgent need for clinically relevant biomarkers capable of distinguishing between aggressive and non-aggressive forms of prostate cancer to aid in stratification, management and therapeutic decisions. To address this unmet need, we investigated the patterns of expression of a panel of 68 plasma-derived microRNAs (miRNAs) in a cohort of African American (AA) and European American (EA) prostate cancer patients (n=114)...
February 17, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29471407/plasma-copeptin-as-a-predictor-of-kidney-disease
#3
Sofia Enhörning, Anders Christensson, Olle Melander
Background: Plasma copeptin, a marker of vasopressin, is associated with renal function decline in the general population. Our aim was to study the links between elevated copeptin and future risk of kidney disease. Methods: Copeptin was measured in a sample of the Malmö Preventive Project (MPP) Reinvestigation (n = 5158) and in the Malmö Diet and Cancer Cardiovascular Cohort (MDC-CC) (n = 5162). According to national registers, 89 subjects in MPP and 180 in MDC-CC developed chronic kidney disease (CKD) during follow-up (8...
February 16, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29471387/heavy-cannabis-use-associated-with-reduction-in-activated-and-inflammatory-immune-cell-frequencies-in-antiretroviral-therapy-treated-human-immunodeficiency-virus-infected-individuals
#4
Jennifer A Manuzak, Toni M Gott, Jay S Kirkwood, Ernesto Coronado, Tiffany Hensley-McBain, Charlene Miller, Ryan K Cheu, Ann C Collier, Nicholas T Funderburg, Jeffery N Martin, Michael C Wu, Nina Isoherranen, Peter W Hunt, Nichole R Klatt
Background: Cannabis is a widely used drug in the United States, and the frequency of cannabis use in the human immunodeficiency virus (HIV)-infected population is disproportionately high. Previous human and macaque studies suggest that cannabis may have an impact on plasma viral load; however, the relationship between cannabis use and HIV-associated systemic inflammation and immune activation has not been well defined. Methods: The impact of cannabis use on peripheral immune cell frequency, activation, and function was assessed in 198 HIV-infected, antiretroviral-treated individuals by flow cytometry...
February 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29471322/whole-body-nitrogen-utilization-and-tissue-protein-and-casein-synthesis-in-lactating-primiparous-sows-fed-low-and-high-protein-diets
#5
Lee-Anne Huber, Marko Rudar, Nathalie L Trottier, John P Cant, Cornelis F M de Lange
Twenty-eight lactating Yorkshire and Yorkshire × Landrace primiparous sows were used to test the hypothesis that feeding a diet with reduced CP concentration and supplemented with crystalline amino acids (CAA) does not decrease milk protein yield and litter growth but improves apparent N utilization for milk protein production. Sows were assigned to 1 of 2 dietary treatments: [1] Control (CON; 16.2% CP; analyzed content) or [2] Low CP with CAA to meet estimated requirements of limiting amino acids (LCP; 12...
February 19, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29471321/overexpression-of-heparanase-in-mice-promoted-megakaryopoiesis
#6
Ying-Xia Tan, Hao Cui, Lu-Ming Wan, Feng Gong, Xiao Zhang, Israel Vlodavsky, Jin-Ping Li
Heparanase, an endo-glucuronidase that specifically cleaves heparan sulfate, is upregulated in several pathological conditions. In this study, we aimed to find a correlation of heparanase expression and platelets production. In the transgenic mice overexpressing human heparanase (Hpa-tg), hematological analysis of blood samples revealed a significantly higher number of platelets in comparison with wild-type (Ctr) mice, while no significant difference was found in leukocytes and red blood cell number between the two groups...
February 19, 2018: Glycobiology
https://www.readbyqxmd.com/read/29471284/adverse-metabolic-effects-in-fish-exposed-to-contaminants-of-emerging-concern-in-the-field-and-laboratory
#7
James P Meador, Andrew Yeh, Evan P Gallagher
Several metabolic parameters were assessed in juvenile Chinook salmon (Oncorhynchus tshawytscha) and staghorn sculpin (Leptocottus armatus) residing in two estuaries receiving wastewater treatment effluent and one reference estuary. We also conducted a laboratory study with fish dosed for 32 days with 16 of the most common contaminants of emerging concern (CECs) detected in feral fish. Several blood chemistry parameters and other indicators of health were measured in fish from the field and laboratory study that were used to assess potential metabolic disruption...
February 19, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29471261/regulation-of-cortical-and-peripheral-gch1-expression-and-biopterin-levels-in-schizophrenia-spectrum-disorders
#8
James D Clelland, Laura L Read, Jennifer Smeed, Catherine L Clelland
Tetrahydrobiopterin (BH4 ) is an essential cofactor for dopamine, serotonin and nitric oxide synthesis. Deficits of plasma total biopterin (a measure of BH4 ) have been described in schizophrenia and schizoaffective disorder. GCH1 encodes the first and rate-limiting enzyme in BH4 synthesis. Peripheral GCH1 expression is lower in first episode psychosis patients versus controls, and we hypothesized that a GCH1 promoter polymorphism associated with psychiatric illness, contributes to regulation of both GCH1 expression and BH4 levels...
February 8, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29471240/a-multiregional-survey-of-nickel-in-outdoor-air-particulate-matter-in-china-implication-for-human-exposure
#9
Han Li, Yanjian Wan, Xiao Chen, Lu Cheng, Xueyu Yang, Wei Xia, Shunqing Xu, Hongling Zhang
Nickel is a widespread environmental contaminant, and it is toxic to humans in certain forms at high doses. Despite this, nationwide data on nickel in outdoor air particulate matter and human exposure to nickel through inhalation in China are limited. In the present study, 662 outdoor air samples from seven representative provinces such as Shanghai, Hubei, Hunan, Hebei, Guangdong, Yunnan, and Shanxi were collected between March 2013 and February 2014 and analyzed by inductively coupled plasma mass spectrometry...
February 19, 2018: Chemosphere
https://www.readbyqxmd.com/read/29471224/quantification-of-desoxyrhapontigenin-4-methoxyresveratrol-in-rat-plasma-by-lc-ms-ms-application-to-pre-clinical-pharmacokinetic-study
#10
Yu Dai, Amanda Li Cheng Tan, Huan Chen, Pei Shi Ong, Xiaoqiang Xiang, Jinzhu Wu, Hai-Shu Lin
Desoxyrhapontigenin (DRG, 4-methoxyresveratrol or trans-3,5-dihydroxy-4'-methoxystilbene) is a naturally occurring resveratrol (RES) derivative with a variety of biological activities. To facilitate its further medicinal exploration, a reliable LC-MS/MS method was developed and validated for the quantification of DRG in rat plasma using heavy isotope labelled RES as an internal standard. The ESI was operated in its negative ion mode while DRG and RES were determined by multiple reaction monitoring (MRM) using precursor-to-product ion transitions of m/z 241...
February 13, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29471136/post-weaning-piglets-fed-with-different-levels-of-fungal-mycotoxins-and-spray-dried-porcine-plasma-have-improved-weight-gain-feed-intake-and-reduced-diarrhea-incidence
#11
Lucieli Kamila Focht Müller, Diovani Paiano, Jeferson Gugel, William Raphael Lorenzetti, Janio Morais Santurio, Fernando de Castro Tavernari, Eduardo Micotti da Gloria, Matheus D Baldissera, Aleksandro Schafer Da Silva
Mycotoxins are responsible for economic losses in the swine production industry, especially during post-weaning, when piglets are physiologically immature. Spray-dried porcine plasma (SDPP), added to pig diets, may help reduce losses due to mycotoxins. This work investigates the effects of SDPP in post-weaning piglets fed with diets containing natural contaminants or with more contaminants (co-contamination by mycotoxins). Fifty-six castrated weaned piglets were used in a randomized 2 (0 and 6% of SDPP) x 2 (natural contamination or co-contamination with mycotoxin) factorial design, with seven experimental units of two piglets each...
February 19, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29471072/neuroreflex-control-of-cardiovascular-function-is-impaired-after-acute-poisoning-with-chlorpyrifos-an-organophosphorus-insecticide-possible-short-and-long-term-clinical-implications
#12
Alexandre F Cunha, Igor S A Felippe, Nilson C Ferreira-Junior, Leonardo B M Resstel, Daniela A M Guimarães, Vanessa Beijamini, Julian F R Paton, Karla N Sampaio
Although it is well-established that severe poisoning by organophosphorus (OP) compounds strongly affects the cardiorespiratory system, the effects of sub-lethal exposure to these compounds on the neural control of cardiovascular function are poorly explored. The aim of this study was to evaluate the effects of acute sub-lethal exposure to chlorpyrifos (CPF), a commonly used OP insecticide, on three basic reflex mechanisms involved in blood pressure regulation, the peripheral chemoreflex, the baroreflex and the Bezold-Jarisch reflex...
February 19, 2018: Toxicology
https://www.readbyqxmd.com/read/29471067/the-smell-of-renal-protection-against-chronic-kidney-disease-hydrogen-sulfide-offers-a-potential-stinky-remedy
#13
REVIEW
George J Dugbartey
Chronic kidney disease (CKD) is a common global health challenge characterized by irreversible pathological processes that reduce kidney function and culminates in development of end-stage renal disease. It is associated with increased morbidity and mortality in addition to increased caregiver burden and higher financial cost. A central player in CKD pathogenesis and progression is renal hypoxia. Renal hypoxia stimulates induction of oxidative and endoplasmic reticulum stress, inflammation and tubulointerstitial fibrosis, which in turn, promote cellular susceptibility and further aggravate hypoxia, thus forming a pathological vicious cycle in CKD progression...
October 19, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29471066/a-pharmacokinetic-study-on-lapatinib-in-type-2-diabetic-rats
#14
Agnieszka Karbownik, Edyta Szałek, Katarzyna Sobańska, Agnieszka Klupczynska, Szymon Plewa, Tomasz Grabowski, Anna Wolc, Marta Moch, Zenon J Kokot, Edmund Grześkowiak
BACKGROUND: Diabetes mellitus (DM) is a complex metabolic disorder which affects the function of numerous tissues and alters the pharmacokinetic parameters of many drugs. As many oncological patients are diabetics, it is important to determine the influence of this chronic disease on the pharmacokinetics (PK) of anticancer drugs. Lapatinib is a tyrosine kinase inhibitor (TKI), approved for the treatment of human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer...
September 18, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29471015/biological-profiling-of-plasma-neuropeptide-y-in-relation-to-posttraumatic-stress-symptoms-in-two-combat-cohorts
#15
Alieke Reijnen, Elbert Geuze, Iris Eekhout, Adam X Maihofer, Caroline M Nievergelt, Dewleen G Baker, Eric Vermetten
In order to decrease the risk of developing stress-related disorders after military deployment, biological vulnerability factors should be identified. Neuropeptide Y (NPY) is a peptide neurotransmitter that is associated with modulation of the stress response. Using the data of two longitudinal prospective cohort studies (N = 892 and N = 2427), plasma NPY (pNPY) was assessed as a possible susceptibility biomarker for the development of PTSD symptoms over time. Data collection started prior to deployment and follow-up assessments were completed up to two years after deployment...
February 19, 2018: Biological Psychology
https://www.readbyqxmd.com/read/29470988/shear-dependent-fibrillogenesis-of-fibronectin-impact-of-platelet-integrins-and-actin-cytoskeleton
#16
Huong Nguyen, Khon Huynh, Volker R Stoldt
Soluble plasma fibronectin (Fn) with its inactive compact structure requires unfolding to assemble into active fibrils, which play a role in hemostasis and thrombosis. Fn fibril assembly involves Fn binding to cell receptors, biomechanical coupling of Fn to the cytoskeleton by integrins, exposure of self-assembly sites via contractile cell forces, and elongation of fibrils by Fn polymerization. In this report, we investigated the effect of platelet integrins and actin cytoskeleton on conformational changes of Fn induced by shear...
February 19, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29470953/cat-preantral-follicle-survival-after-prolonged-cooled-storage-followed-by-vitrification
#17
Jorge Luis Araújo Martins, Maria Denise Lopes, Fabiana Ferreira de Souza, Fabio Sossai Possebon, Gudrun Wibbelt, Katarina Jewgenow
The aim of this study was to investigate the impact of prolonged storage at 4 °C on survival of cat preantral follicles (PAFs) pre- and post-vitrification. Ovaries were obtained from 12 queens and transported at 4 ºC within 2-6 h. Parts of the ovaries were stored for an additional 24 h or 72 h. The ovarian cortex was dissected, analyzed for viability (neutral red - NR) and morphology (histology - HE and ultrastructural analysis by TEM) and vitrified. We used 2 mm biopsy punches to obtain equal size pieces as the experimental units...
February 19, 2018: Cryobiology
https://www.readbyqxmd.com/read/29470848/simultaneous-determination-of-evodiamine-and-its-four-metabolites-in-rat-plasma-by-lc-ms-ms-and-its-application-to-a-pharmacokinetic-study
#18
Cuiyun Wang, Fang Yue, Guangfeng Ai, Jie Yang
A simple and sensitive liquid chromatography tandem mass spectrometry method was validated for simultaneous quantification of evodiamine and its metabolites 10-hydroxyevodiamine (M1), 18-hydroxyevodiamine (M2), 10-hydroxyevodiamine-glucuronide (M3) and 18-hydroxy- evodiamine-glucuronide (M4) in rat plasma for the first time. The analytes were extracted with acetonitrile and separated on a C18 column within 3 min. The detection was achieved in positive selected reaction monitoring mode with precursor-to-product transitions at m/z 304...
February 22, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29470816/hepatic-subcellular-distribution-of-squalene-changes-according-to-the-experimental-setting
#19
Roberto Martínez-Beamonte, Olga Alda, Teresa Sanclemente, María J Felices, Sara Escusol, Carmen Arnal, Luis V Herrera-Marcos, Sonia Gascón, Joaquín C Surra, Jesús Osada, Mª Jesús Rodríguez-Yoldi
Squalene is the main unsaponifiable component of virgin olive oil, the main source of dietary fat in Mediterranean diet, traditionally associated with a less frequency of cardiovascular diseases. In this study, two experimental approaches were used. In the first, New Zealand rabbits fed for 4 weeks with a chow diet enriched in 1% sunflower oil for the control group, and in 1% of sunflower oil and 0.5% squalene for the squalene group. In the second, APOE KO mice received either Western diet or Western diet enriched in 0...
February 22, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29470764/levels-of-circulating-mrna-for-the-tenascin-x-tnxb-gene-in-maternal-plasma-at-the-second-trimester-in-pregnancies-with-isolated-congenital-ventricular-septal-defects
#20
Danila Morano, Silvia Berto, Cristina Lapucci, Lara Walczer Baldinazzo, Daniela Prandstraller, Antonio Farina
OBJECTIVE: Maternal plasma is a source of circulating placental nucleic acids. In this study, we validated previous observations on abnormal levels of circulating messenger RNA (mRNA) for the tenascin-X gene in pregnancies with ventricular septal defects in the second trimester of pregnancy. METHODS: This was a bicentric retrospective study conducted from March 2016 to July 2017. Real-time polymerase chain reaction was used to identify abnormally expressed genes, comparing ten women carrying a euploid fetus with ventricular septal defects to 30 controls at 19-24 weeks of gestation...
February 22, 2018: Molecular Diagnosis & Therapy
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