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https://www.readbyqxmd.com/read/29245086/liquid-chromatography-tandem-mass-spectrometric-assay-for-the-quantitation-of-the-novel-radiation-protective-agent-and-radiation-mitigator-jp4-039-in-murine-plasma
#1
Susan Christner, Jianxia Guo, Robert A Parise, Melanie Ringeval, Adam T Hoye, Peter Wipf, Michael W Epperly, Joel S Greenberger, Jan H Beumer, Julie L Eiseman
JP4-039 radio-protects prior to, and radio-mitigates after ionizing radiation by neutralizing reactive oxygen species. We developed and validated an LC-MS/MS assay for the quantitation of JP4-039 in murine plasma. Methanol protein precipitation of 50μL plasma was followed by isocratic reverse phase chromatography for a 6min run time, and electrospray positive mode ionization mass spectrometric detection. The plasma assay was linear from 1 to 1000ng/mL with appropriate accuracy (97.1-107.6%) and precision (3...
December 12, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29245065/diclofenac-induced-renal-toxicity-in-female-wistar-albino-rats-is-protected-by-the-pre-treatment-of-aqueous-leaves-extract-of-madhuca-longifolia-through-suppression-of-inflammation-oxidative-stress-and-cytokine-formation
#2
Jerine Peter S, Sabina Evan Prince
CONTEXT: Kidney has a vital role in renal clearance, maintenance of blood pressure, elimination of toxic products and formation of prostaglandins. Certain medications are known to cause renal injury on its frequent usage and high dosage. Diclofenac is a non-steroidal anti-inflammatory drug which is used in the treatment of pain and arthritis. Madhuca longifolia is a deciduous tree which is known to the have anti-microbial, anti-ulcer, hepatoprotective, anti-diabetic, anti-inflammatory and analgesic activity...
December 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29245039/prenatal-arsenic-exposure-child-marriage-and-pregnancy-weight-gain-associations-with-preterm-birth-in-bangladesh
#3
Mohammad L Rahman, Molly L Kile, Ema G Rodrigues, Linda Valeri, Anita Raj, Maitreyi Mazumdar, Golam Mostofa, Quazi Quamruzzaman, Mahmudur Rahman, Russ Hauser, Andrea Baccarelli, Liming Liang, David C Christiani
BACKGROUND: Preterm birth is a disease of multifactorial etiologies that has environmental, social, and maternal health components. Individual studies have shown that exposure to arsenic contaminated drinking water, child marriage, and low maternal weight gain during pregnancy contribute to preterm birth. These factors are highly prevalent and often co-exist in Bangladesh, a country in South Asia with one of the world's highest prevalences of preterm birth. OBJECTIVE: To evaluate the individual and interactive effects of prenatal arsenic exposure, child marriage, and pregnancy weight gain on preterm birth in a prospective birth cohort in Bangladesh...
December 12, 2017: Environment International
https://www.readbyqxmd.com/read/29245030/osmotin-a-plant-defense-tool-against-biotic-and-abiotic-stresses
#4
REVIEW
Hakim, Abid Ullah, Amjad Hussain, Muhammad Shaban, Aamir Hamid Khan, Muna Alariqi, Summia Gul, Zhang Jun, Sun Lin, Jianying Li, Shuangxia Jin, Muhammad Farooq Hussain Munis
Plants are prone to a number of pathogens and abiotic stresses that cause various disorders. However, plants possess a defense mechanism to cope with these stresses. The osmotin protein belongs to the PR-5 family of Pathogenesis-related (PR) proteins, which are produced in response to diseases caused by various biotic and abiotic stresses. Osmotin uses a signal transduction pathway to inhibit the activity of defensive cell wall barriers and increases its own cytotoxic efficiency. However, in response to cytotoxic effects, this pathway stimulates a mitogen-activated protein kinase (MAPK) cascade that triggers changes in the cell wall and enables osmotin's entrance into the plasma membrane...
December 7, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29245000/does-traumatic-brain-injury-hold-the-key-to-the-alzheimer-s-puzzle
#5
Robert E Becker, Dimitrios Kapogiannis, Nigel H Greig
INTRODUCTION: Neurodegenerative disorders have been a graveyard for hundreds of well-intentioned efforts at drug discovery and development. Concussion and other traumatic brain injuries (TBIs) and Alzheimer's disease (AD) share many overlapping pathologies and possible clinical links. METHODS: We searched the literature since 1995 using MEDLINE and Google Scholar for the terms concussion, AD, and shared neuropathologies. We also studied a TBI animal model as a supplement to transgenic (Tg) mouse AD models for evaluating AD drug efficacy by preventing neuronal losses...
December 12, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29244965/management-of-chronic-diabetic-foot-ulcers-using-platelet-rich-plasma
#6
V Babaei, H Afradi, H Z Gohardani, F Nasseri, M Azarafza, S Teimourian
OBJECTIVE: Platelet-rich plasma (PRP) has been proposed as an adjunct for the treatment of foot ulcers in patients with diabetes, as well as a treatment for chronic and acute wounds. This study examined the application of PRP in the treatment of diabetic foot ulcers (DFUs) in patients. METHODS: This prospective study was conducted between 2011 and 2014. We used PRP, produced by a kit, for the treatment of DFUs. Patients were allocated to one of three groups, according to size of ulcer...
December 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/29244859/the-second-molecular-epidemiological-study-of-hiv-infection-in-mongolia-between-2010-and-2016
#7
Davaalkham Jagdagsuren, Tsunefusa Hayashida, Misao Takano, Erdenetuya Gombo, Setsen Zayasaikhan, Naomi Kanayama, Kiyoto Tsuchiya, Shinichi Oka
OBJECTIVE: Our previous 2005-2009 molecular epidemiological study in Mongolia identified a hot spot of HIV-1 transmission in men who have sex with men (MSM). To control the infection, we collaborated with NGOs to promote safer sex and HIV testing since mid-2010. In this study, we carried out the second molecular epidemiological survey between 2010 and 2016 to determine the status of HIV-1 infection in Mongolia. METHODS: The study included 143 new cases of HIV-1 infection...
2017: PloS One
https://www.readbyqxmd.com/read/29244857/maternal-plasma-angiogenic-and-inflammatory-factor-profiling-in-foetal-down-syndrome
#8
Monika Zbucka-Kretowska, Karol Charkiewicz, Joanna Goscik, Slawomir Wolczynski, Piotr Laudanski
OBJECTIVE AND DESIGN: Angiogenic factors are proteins that are related to certain foetal chromosomal abnormalities. The aim of this study was to determine the concentration of 60 angiogenic factors in the plasma of women with offspring possessing trisomy 21/Down syndrome (DS). METHOD: After analysing karyotyping results, we selected 20 patients with foetuses possessing DS, and for the control group, we selected 28 healthy patients with uncomplicated pregnancies who delivered healthy newborns at term (i...
2017: PloS One
https://www.readbyqxmd.com/read/29244742/fibrinogen-gamma-chain-mutations-provoke-fibrinogen-and-apolipoprotein-b-plasma-deficiency-and-liver-storage
#9
Francesco Callea, Isabella Giovannoni, Sinan Sari, Esendagli Guldal, Buket Dalgic, Gulen Akyol, Tsuyoshi Sogo, Abdulrahman Al-Hussaini, Giuseppe Maggiore, Andrea Bartuli, Renata Boldrini, Paola Francalanci, Emanuele Bellacchio
p.R375W (Fibrinogen Aguadilla) is one out of seven identified mutations (Brescia, Aguadilla, Angers, Al du Pont, Pisa, Beograd, and Ankara) causing hepatic storage of the mutant fibrinogen γ. The Aguadilla mutation has been reported in children from the Caribbean, Europe, Japan, Saudi Arabia, Turkey, and China. All reported children presented with a variable degree of histologically proven chronic liver disease and low plasma fibrinogen levels. In addition, one Japanese and one Turkish child had concomitant hypo-APOB-lipoproteinemia of unknown origin...
December 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29244713/nanoengineered-interfaces-coatings-and-structures-by-plasma-techniques
#10
EDITORIAL
Krasimir Vasilev, Melanie Macgregor Ramiasa
Nanoparticles, nanotubes, nanobelts, nanoneedles, nanosheets, nanowires, nanopillars: the variety of nanostructured interfaces that can be created and modified using plasma processes is virtually endless.[...].
December 15, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29244655/duplex-imprinted-nano-well-arrays-for-promising-nanoparticles-assembly
#11
Xiangping Li, Andreas Manz
A large area nano-duplex-imprint technique is presented in this contribution using natural cicada wings as stamp. The glassy wings of the cicada, which are abundant in nature, exhibit strikingly interesting nanopillar structures over their membrane. This technique, with excellent performance despite the nonplanar surface of the wings, combines the top-down and bottom-up nanofabrication techniques. It transits micro-nanofabrication from cleanroom environment to bench. Two different materials - dicing tape with acrylic layer and UV optical adhesive - are used to make replications at the same time, thus achieving duplex imprint...
December 15, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29244647/diagnosis-and-treatment-of-hyperkalemia
#12
REVIEW
Biff F Palmer, Deborah J Clegg
Hyperkalemia results either from the shift of potassium out of cells or from abnormal renal potassium excretion. Cell shift leads to transient increases in the plasma potassium concentration, whereas decreased renal excretion of potassium leads to sustained hyperkalemia. Impairments in renal potassium excretion can be the result of reduced sodium delivery to the distal nephron, decreased mineralocorticoid level or activity, or abnormalities in the cortical collecting duct. In some instances, all 3 of these perturbations are present...
December 2017: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/29244631/initial-results-of-peripheral-blood-stem-cell-mobilization-collection-cryopreservation-and-engraftment-after-autologous-transplantation-confirm-that-the-capacity-building-approach-offers-good-chances-of-success-in-critical-contexts-a-kurdish-italian-cooperative
#13
Ignazio Majolino, Dereen Mohammed, Dastan Hassan, Francesco Ipsevich, Chra Abdullah, Rebar Mohammed, Angelo Palmas, Marco Possenti, Diana Noori, Dlir Ali, Harem Karem, Salah Salih, Michele Vacca, Claudia Del Fante, Angelo Ostuni, Andrea Frigato, Maria Speranza Massei, Annunziata Manna, Stefania Vasta, Marcela Gabriel, Marta Verna, Attilio Rovelli, Valentino Conter, Kosar Ali, Dosti Othman
Introduction At Hiwa Cancer Hospital (Sulaymaniyah, Iraqi Kurdistan) after the center was started by a cooperative project in June 2016, autologous transplantation was developed. Patients and Methods To develop the project, the capacity-building approach was adopted, with on-site training and coaching of personnel, educational meetings, lectures, on-the-job training, and the implementation of quality management planning. Results Here, we report initial results of peripheral-blood stem-cell mobilization and collection of the first 27 patients (age 12 to 61 years; 19 males and 8 females; multiple myeloma, n = 10; plasma cell leukemia, n = 1; Hodgkin lymphoma, n = 12; non-Hodgkin lymphoma, n = 3; and acute myeloid leukemia, n = 1)...
December 15, 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29244617/differentiation-of-high-grade-from-low-grade-astrocytoma-improvement-in-diagnostic-accuracy-and-reliability-of-pharmacokinetic-parameters-from-dce-mr-imaging-by-using-arterial-input-functions-obtained-from-dsc-mr-imaging
#14
Sung-Hye You, Seung Hong Choi, Tae Min Kim, Chul-Kee Park, Sung-Hye Park, Jae-Kyung Won, Il Han Kim, Soon Tae Lee, Hye Jeong Choi, Roh-Eul Yoo, Koung Mi Kang, Tae Jin Yun, Ji-Hoon Kim, Chul-Ho Sohn
Purpose To evaluate whether arterial input functions (AIFs) derived from dynamic susceptibility-contrast (DSC) magnetic resonance (MR) imaging, or AIFDSC values, improve diagnostic accuracy and reliability of the pharmacokinetic (PK) parameters of dynamic contrast material-enhanced (DCE) MR imaging for differentiating high-grade from low-grade astrocytomas, compared with AIFs obtained from DCE MR imaging (AIFDCE). Materials and Methods This retrospective study included 226 patients (138 men, 88 women; mean age, 52...
December 15, 2017: Radiology
https://www.readbyqxmd.com/read/29244485/critical-role-of-trp-588-of-presynaptic-munc13-1-for-ligand-binding-and-membrane-translocation
#15
Joydip Das, Noemi Kedei, Jessica S Kelsey, Youngki You, Satyabrata Pany, Gary A Mitchell, Nancy E Lewin, Peter M Blumberg
Munc13-1 is a presynaptic active-zone protein essential for neurotransmitter release and presynaptic plasticity in the brain. This multi-domain scaffold protein contains a C1 domain that binds to the activator diacylglycerol/phorbol ester. Although the C1 domain bears close structural homology with the C1 domains of protein kinase C (PKC), the tryptophan residue at position 22 (588 in the full-length Munc13-1) occludes the activator binding pocket, which is not the case for PKC. To elucidate the role of this tryptophan, we generated W22A, W22K, W22D, W22Y and W22F substitutions in the full-length Munc13-1, expressed the GFP- tagged constructs in Neuro-2a cells, and measured their membrane translocation in response to phorbol ester treatment by imaging of the live cells using confocal microscopy...
December 15, 2017: Biochemistry
https://www.readbyqxmd.com/read/29244251/effect-of-combination-folic-acid-vitamin-b6-and-vitamin-b12-supplementation-on-fracture-risk-in-women-a-randomized-controlled-trial
#16
Katie L Stone, Li-Yung Lui, William G Christen, Aron M Troen, Douglas C Bauer, Deborah Kado, Christopher Schambach, Steven R Cummings, JoAnn E Manson
Epidemiologic studies have demonstrated an association of elevated plasma homocysteine levels with greater bone resorption and fracture risk. Vitamins B12 , B6 , and folic acid are cofactors in homocysteine metabolism, and supplementation with B vitamins is effective in lowering homocysteine levels in humans. However, randomized trials of supplemental B vitamins for reduction of fracture risk have been limited. Therefore, we performed an ancillary study to the Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS), a large randomized trial of women with preexisting cardiovascular disease or three or more coronary risk factors, to test whether a daily B vitamin intervention including folic acid (2...
December 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29244241/vitamin-d-and-gestational-diabetes-mellitus-a-systematic-review-based-on-data-free-of-hawthorne-effect
#17
Yanbo Zhang, Yunhui Gong, Hongmei Xue, Jingyuan Xiong, Guo Cheng
BACKGROUND: Gestational diabetes mellitus (GDM) is an increasingly prevalent disorder, associated with low blood vitamin D (VD) level. OBJECTIVES: To evaluate the relationship between VD and GDM. SEARCH STRATEGY: EMBASE, MEDLINE, Cochrane library and China Biology Medicine disc were searched till May 2017. The references of previous studies were screened. SELECTION CRITERIA: Observational studies on the relationship between VD and GDM free from Hawthorne effect and randomized controlled trials of VD supplementation during pregnancy for preventing or treating GDM were included...
December 15, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29244215/development-of-a-validated-liquid-chromatographic-method-for-quantification-of-sorafenib-tosylate-in-the-presence-of-stress-induced-degradation-products-and-in-biological-matrix-employing-analytical-quality-by-design-aqbd-approach
#18
Teenu Sharma, Rajneet Kaur Khurana, Atul Jain, O P Katare, Bhupinder Singh
The current research work envisages AQbD-enabled development of a simple, rapid, sensitive, specific, robust and cost-effective stability indicating reversed phase high performance liquid chromatographic (RP-HPLC) method for determining stress-induced forced degradation products of sorafenib tosylate (SFN). An Ishikawa fish bone diagram was constructed to embark upon analytical target profile (ATP) and critical analytical attributes (CAAs) i.e., peak area, theoretical plates, retention time (Rt ) and peak tailing...
December 15, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29244127/comparison-of-efficiency-of-purification-from-human-plasma-of-a-nerve-agent-adduct-of-butyrylcholinesterase-between-the-affinity-gel-method-and-immunomagnetic-separation
#19
Jin Young Lee
O-ethyl S-2-diisopropylaminoethyl methyl phosphonothiolate (VX) is a highly toxic chemical warfare agent because it inhibits cholinesterase (ChE) activity in the nervous system. Inhibition of butyrylcholinesterase (BChE) activity by VX is due to formation of a phosphorylated BChE adduct; this adduct in human plasma can serve as a biomarker of exposure to nerve agents. We compared purification efficiency between the procainamide affinity gel method and immunomagnetic separation (IMS) for the nerve agent adduct of BChE in plasma and then optimized the sample preparation by purifying BChE to measure biomarkers of human exposure to organophosphorus nerve agents...
December 13, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/29244118/lower-dolutegravir-plasma-concentrations-in-hiv-positive-patients-receiving-valproic-acid
#20
Annagloria Palazzo, Mattia Trunfio, Veronica Pirriatore, Maurizio Milesi, Amedeo De Nicolò, Chiara Alcantarini, Antonio D'Avolio, Stefano Bonora, Giovanni Di Perri, Andrea Calcagno
No abstract text is available yet for this article.
December 12, 2017: Journal of Antimicrobial Chemotherapy
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