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https://www.readbyqxmd.com/read/29055264/differences-in-immunomodulatory-properties-between-venlafaxine-and-paroxetine-in-patients-with-major-depressive-disorder
#1
Chun-Yen Chen, Yi-Wei Yeh, Shin-Chang Kuo, Chih-Sung Liang, Pei-Shen Ho, Chang-Chih Huang, Che-Hung Yen, Jia-Fwu Shyu, Ru-Band Lu, San-Yuan Huang
Inflammatory processes play a crucial role in the pathophysiology of depression, and identifying the specific cytokines targeted by different antidepressants is important for personalized treatment. The aims of this study were to examine whether venlafaxine and paroxetine cause different immunomodulatory effects when used to treat patients with major depression and to clarify the relationships between plasma cytokine levels and the therapeutic effectiveness of these drugs. A total of 91 Han Chinese patients with major depression completed the 8-week paroxetine or venlafaxine treatment and 90 healthy controls were recruited...
October 12, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29055248/simultaneous-quantification-of-direct-oral-anticoagulants-currently-used-in-anticoagulation-therapy
#2
Kathrin I Foerster, Andrea Huppertz, Oliver J Müller, Timolaos Rizos, Lisa Tilemann, Walter E Haefeli, Jürgen Burhenne
Direct oral anticoagulants (DOACs) are among the most effective options to prevent serious thromboembolic events in patients with atrial fibrillation. Coagulation assays are used to assess DOAC activity, but lack the possibility to quantify drugs with concurrent pharmacodynamic effect. We developed a selective multi-drug assay to analyze apixaban, betrixaban, dabigatran, edoxaban, edoxaban M4, and rivaroxaban with ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC/MS/MS) in plasma fulfilling all requirements of the FDA und EMA guidelines for bioanalytical method validation...
October 16, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29055166/drug-monitoring-of-sunitinib-in-patients-with-advanced-solid-tumors-a-monocentric-observational-french-study
#3
Luc Cabel, Benoit Blanchet, Audrey Thomas-Schoemann, Olivier Huillard, Audrey Bellesoeur, Anatole Cessot, Julie Giroux, Pascaline Boudou-Rouquette, Romain Coriat, Michel Vidal, Nathaniel E B Saidu, Lisa Golmard, Jérome Alexandre, Francois Goldwasser
Therapeutic drug monitoring (TDM) could be helpful in oral targeted therapies. Data are sparse to evaluate its impact on treatment management. This study aimed to determine a threshold value of plasma drug exposure associated with the occurrence of grade 3-4 toxicity, then the potential impact of TDM on clinical decision. Consecutive outpatients treated with sunitinib were prospectively monitored between days 21-28 of the first cycle, then monthly until disease progression. At each consultation, the composite AUCƬ,ss (sunitinib + active metabolite SU12662) was assayed...
October 21, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29055158/a-phase-2a-randomized-controlled-study-to-evaluate-the-pharmacokinetic-safety-tolerability-and-clinical-effect-of-topically-applied-umeclidinium-in-subjects-with-primary-axillary-hyperhidrosis
#4
A Nasir, R Bissonnette, C Maari, J DuBois, T Pene Dumitrescu, J Haddad, Y Yamaguchi, M Dalessandro
BACKGROUND: Hyperhidrosis is a common medical condition which can have a significant impact on quality of life. Umeclidinium (UMEC) is a long acting muscarinic antagonist (LAMA) developed as a dermal formulation. OBJECTIVES: This 2-week, double-blind, randomized, vehicle-controlled study evaluated systemic exposure, safety, and tolerability of topically administered UMEC in subjects with primary axillary hyperhidrosis. Clinical effect was a secondary objective, measured by gravimetry and the hyperhidrosis disease severity scale (HDSS)...
October 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29055146/association-between-natural-killer-cell-activity-and-the-risk-of-colorectal-neoplasia
#5
Yoon Suk Jung, Min-Jung Kwon, Dong Il Park, Chong Il Sohn, Jung Ho Park
BACKGROUND: Low activity of natural killer (NK) cells is known to be associated with higher risk of cancer, especially with poor prognosis and the presence of colorectal cancer (CRC). We investigated whether NK cells activity differs between subjects with and without colorectal neoplasia (CRN). METHODS: A cross-sectional study was performed on 1818 asymptomatic examinees aged ≥30 years who underwent NK cell activity test (which quantitates the amount of interferon-γ secreted into the plasma by NK cells) and a colonoscopy as part of a health check-up...
October 21, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29055065/simultaneous-determination-of-usnic-diffractaic-evernic-and-barbatic-acids-in-rat-plasma-by-ultra-high-performance-liquid-chromatography-quadrupole-exactive-orbitrap-mass-spectrometry-and-its-application-to-pharmacokinetic-studies
#6
Hanxue Wang, Tao Yang, Xuemei Cheng, Sukfan Kwong, Chenghai Liu, Rui An, Guowen Li, Xinhong Wang, Changhong Wang
Usnea longissima Ach. (Usnea) has been used in pharmaceuticals, food, cosmetics. Evernic acid (EA), barbatic acid (BA), diffractaic acid (DA), and usnic acid (UA) are the most typical ingredients in U. longissima and exert a wide variety of biological functions. The study aim to develop a sensitive method for simultaneous analysis of EA, BA, DA, and UA in rat plasma and applied to pharmacokinetic studies after consumption of UA and ethanol extract from U. longissima (UE). The samples were separated on BEH C18 column by gradient elution with 0...
October 21, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29055004/stat4-regulates-the-cd8-regulatory-t-cell-t-follicular-helper-cell-axis-and-promotes-atherogenesis-in-insulin-resistant-ldlr-mice
#7
Parésa L Taghavie-Moghadam, Tayab C Waseem, Julian Hattler, Lindsey M Glenn, Anca D Dobrian, Mark H Kaplan, Yi Yang, Roza Nurieva, Jerry L Nadler, Elena V Galkina
The metabolic syndrome and diabetic conditions support atherosclerosis, but the exact mechanisms for accelerated atherogenesis remain unclear. Although the proinflammatory role of STAT4 in atherosclerosis and diet-induced insulin resistance (IR) was recently established, the impact of STAT4 on atherogenesis in conditions of IR is not known. In this study, we generated Stat4(-/-)Ldlr(-/-) mice that were fed a diabetogenic diet with added cholesterol (DDC). DDC-fed Stat4(-/-)Ldlr(-/-) mice demonstrated improved glucose tolerance, insulin sensitivity, and a 36% reduction in atherosclerosis compared with Ldlr(-/-) controls...
October 20, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29055003/anti-cd20-antibody-prevents-red-blood-cell-alloimmunization-in-a-mouse-model
#8
Rahma Elayeb, Marie Tamagne, Marion Pinheiro, Julie Ripa, Rachid Djoudi, Philippe Bierling, France Pirenne, Benoît Vingert
Alloimmunization against RBCs can cause life-threatening delayed hemolytic transfusion reactions. Anti-CD20 Ab has recently been used to prevent alloimmunization. However, its effects remain unclear, particularly in lymphoid organs. We investigated the impact of murine anti-CD20 Ab in the blood and spleen. We assessed protocols for preventing primary alloimmunization and for abolishing established alloimmunization. Prophylactic protocols prevented alloimmunization. However, anti-CD20 treatment could only limit the further amplification of established alloimmunization...
October 20, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29054981/immunoadsorption-in-anti-gbm-glomerulonephritis-case-report-in-a-child-and-literature-review
#9
Guillaume Dorval, Mathilde Lion, Sophie Guérin, Saoussen Krid, Louise Galmiche-Rolland, Rémi Salomon, Olivia Boyer
Antiglomerular basement membrane glomerulonephritis (anti-GBM GN) is a rare autoimmune disease that is characterized by rapidly progressive glomerulonephritis that may be associated with pulmonary hemorrhage. Anti-GBM GN is caused by autoantibodies (classically type G immunoglobulin) directed against the α3 subunit of type IV collagen. Without any appropriate treatment, the disease is generally fulminant, and patient and kidney survival is poor. The current guidelines recommend the use of plasma exchanges and immunosuppressive drugs...
October 20, 2017: Pediatrics
https://www.readbyqxmd.com/read/29054949/metachronous-solitary-plasmacytoma
#10
Robin Khosa, Shishir Seth, Sapna Nangia
Solitary plasmacytoma is a rare disorder comprising 5%-10% of all plasma cell neoplasms. Progression to multiple myeloma is the most common pattern of relapse. Appearance of new lesions without any systemic disease is the most unusual pattern of relapse seen in <2% cases. We present a case of a 46-year-old female who presented with features of third and seventh cranial nerve palsy, diagnosed with solitary plasmacytoma, with no evidence of any systemic disease. As per standard recommendations, the patient received radiotherapy to the local site...
October 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054907/secondary-aortoduodenal-fistula-and-the-unrecognised-herald-bleed
#11
Francesc Simó Alari, Esther Molina González, Israel Gutierrez, Aïcha Ahamdanech-Idrissi
A 65-year-old man with history of aortobifemoral surgery 4 years ago was admitted to hospital after sudden abdominal pain. Initially misdiagnosed as renal colic, he was treated with analgesics, and while on observation he started with haematemesis, rapidly responding to volume infusion. Upper gastrointestinal endoscopy showed fresh blood in the stomach with no visible active bleeding. CT scan showed an important contrast extravasation from the aorta to the third duodenal portion, restarting haemodynamic instability and a cardiac arrest...
October 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29054840/contemporary-risk-stratification-after-myocardial-infarction-in-the-community-performance-of-scores-and-incremental-value-of-soluble-suppression-of-tumorigenicity-2
#12
Yariv Gerber, Susan A Weston, Maurice Enriquez-Sarano, Allan S Jaffe, Sheila M Manemann, Ruoxiang Jiang, Véronique L Roger
BACKGROUND: Current American Heart Association/American College of Cardiology guidelines recommend the GRACE (Global Registry of Acute Coronary Events) and TIMI (Thrombolysis in Myocardial Infarction) scores to assess myocardial infarction (MI) prognosis. Changes in the epidemiological characteristics of MI and the availability of new biomarkers warrant an assessment of the performance of these scores in contemporary practice. We assessed the following: (1) the performance of GRACE and TIMI to predict 1-year mortality in a cohort of patients stratified by ST-segment elevation MI (STEMI) and non-STEMI (NSTEMI) and (2) the incremental discriminatory power of soluble suppression of tumorigenicity-2, a myocardial fibrosis biomarker...
October 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29054763/association-of-genetic-variants-of-hemostatic-genes-with-myocardial-infarction-in-egyptian-patients
#13
Amal Ahmed Abd El-Fatah, Nermin Abdel Hamid Sadik, Heba Sedrak, Ahmed Battah, Mai Nabil
Hemostatic genes polymorphisms are well known to be associated with venous thrombosis, but their association with arterial thrombosis especially myocardial infarction (MI) remains to be clarified. We investigated the role of three hemostatic gene polymorphisms, prothrombin G20210A, factor XIII (FXIII) Val34Leu (G/T), and fibrinogen-β-455G/A and their coexistence in Egyptian patients with MI. The possible correlation of these polymorphisms with plasma fibrinogen level was also evaluated. The study included 120 patients with MI and 60 healthy volunteers...
October 17, 2017: Gene
https://www.readbyqxmd.com/read/29054761/differential-expression-levels-of-plasma-microrna-in-hashimoto-s-disease
#14
Lijuan Zhao, Xin Zhou, Xia Shan, Lian-Wen Qi, Tongshan Wang, Jun Zhu, Danxia Zhu, Zebo Huang, Lan Zhang, Huo Zhang, Yin Yin, Zhiyan Wang, Wei Zhu, Wenfang Cheng, Lin Jiang
BACKGROUND: The altered expression of circulating miRNAs has been discovered in many autoimmune diseases (ADs). With rare existing research, it is still unclear in Hashimoto's thyroiditis (HT). We detected plasma miRNA expression of HT patients in this three-stage designed study. METHODS: Differently expressed miRNAs (4 HT pools vs. 1 normal control pool) were identified using quantitative reverse transcription polymerase chain reaction (qRT-PCR) based Exiqon panel (miRCURY-Ready-to-Use- PCR-Human- panel-I+II-V1...
October 17, 2017: Gene
https://www.readbyqxmd.com/read/29054590/double-fluorescent-labelling-of-a-bipolar-epithelial-cell-in-vitro-the-outer-hair-cell
#15
Csaba Harasztosi, Entcho Klenske, Susanne Badum, Emese Harasztosi, Anthony W Gummer
BACKGROUND: Fluorescence membrane markers are efficient tools for visualizing the dynamics of membrane recycling processes in living cells. The outer hair cell (OHC) - a bipolar epithelial cell in the cochlea - possesses endocytic activity at both its apical and basal poles. The best visual overview of transcytosis in the OHC is achieved when the cell is isolated, so that both the apical and the basal poles are in the same focal plane to allow confocal imaging. Until now, fluorescent markers were applied to the extracellular environment of isolated OHCs without distinguishing the apical and basal poles...
October 17, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29054504/proteomics-in-plasma-of-ovariectomized-rats-and-those-exposed-to-estradiol-valerate
#16
Hai Jiang, Wenpei Bai, Wenjuan Wang, Ke Wang, Jing Jia, Jing Zhang, He Diao, Lihua Qin
The menopausal period, an inevitable physiological process for women, is frequently associated with physiological and psychological dysfunction attributable to substantial fluctuation and gradual decrease in female hormones induced by ovarian failure, leading to corresponding symptoms and diseases that impact multiple systems in the body to varying degrees. As prior studies have focused primarily on menopausal syndrome-related pathophysiological changes and hormone replacement therapy effects, here we approached menopausal disease incidence risk and pathogenesis through systemic plasma proteomics analysis...
October 17, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29054499/coupled-in-silico-platform-computational-fluid-dynamics-cfd-and-physiologically-based-pharmacokinetic-pbpk-modelling
#17
Aleksandra Vulovic, Tijana Sustersic, Sandra Cvijic, Svetlana Ibric, Nenad Filipovic
One of the critical components of the respiratory drug delivery is the manner in which the inhaled aerosol is deposited in respiratory tract compartments. Depending on formulation properties, device characteristics and breathing pattern, only a certain fraction of the dose will reach the target site in the lungs, while the rest of the drug will deposit in the inhalation device or in the mouth-throat region. The aim of this study was to link the Computational fluid dynamics (CFD) with physiologically-based pharmacokinetic (PBPK) modelling in order to predict aerolisolization of different dry powder formulations, and estimate concomitant in vivo deposition and absorption of amiloride hydrochloride...
October 17, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29054451/phenolic-alkaloid-oleracein-e-attenuates-oxidative-stress-and-neurotoxicity-in-alcl3-treated-mice
#18
Lingyu Li, Yanni Jiao, Tianyun Jin, Hongxiang Sun, Shaoqiang Li, Cuirong Jin, Shuiyao Hu, Jianbo Ji, Lan Xiang
AIMS: Chelation therapy and antioxidant supplements have been demonstrated to be useful in ameliorating aluminum (Al) induced neurotoxicity. Oleracein E (OE) is a phenolic antioxidant alkaloid which possesses a rare tetrahydroisoquinoline/pyrrolidone tricyclic skeleton and a catechol moiety. The aim of this study was to investigate whether OE can chelate with Al and alleviate AlCl3-induced oxidative stress and neurotoxicity. MAIN METHODS: Kunming mice were administered AlCl3 (40mg/kg/d, i...
October 17, 2017: Life Sciences
https://www.readbyqxmd.com/read/29054439/effect-of-storage-time-temperature-antioxidant-and-thawing-on-fatty-acid-composition-of-plasma-serum-and-red-blood-cells-a-pilot-biobank-study
#19
Pedro Araujo, Tormod Bjørkkjær, Livar Frøyland, Rune Waagbø
BACKGROUND: It studies on the factors that affect the stability of fatty acid profiles from human blood specimens are generally performed by evaluating the effect of a single factor on an individual fatty acid and excluding a considerable amount of data from the total fatty acid profiles. METHODS: The stability of fatty acids from plasma, serum and red blood cells (RBC) was evaluated in terms of time, temperature, antioxidant and thawing. The fatty acids were methylated and analyzed by gas chromatography...
October 17, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29054398/association-of-tnf-alpha-gene-polymorphisms-and-susceptibility-to-hepatitis-b-virus-infection-in-egyptians
#20
Roba M Talaat, Mohamed S Abdelkhalek, Eman A El-Maadawy, Wael S Abdel-Mageed, Soha Z El-Shenawy, Mohamed A Osman
Tumor necrosis factor alpha (TNF-α) is one of the important cytokine in generating an immune response against hepatitis B virus (HBV). Genetic polymorphisms might influence gene transcription, leading to disturbance in cytokine production. We hypothesized that single nucleotide polymorphism (SNPs) in TNF-α gene could affect the pathogenesis of HBV. To test this hypothesis, we investigated the role of TNF-α polymorphism [-863C/A (rs1800630), -308G/A (rs1800629), -376G/A (rs1800750), -857C/T (rs1799724) and +489G/A (rs1800610)] in the susceptibility to chronic hepatitis B (CHB) infection...
October 17, 2017: Human Immunology
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