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https://www.readbyqxmd.com/read/29668120/cytomegalovirus-infection-in-living-donor-liver-transplant-recipients-significantly-impacts-the-early-post-transplant-outcome-a-single-center-experience
#1
Sanjay Kumar Yadav, Sanjiv Saigal, Narendra Singh Choudhary, Sujeet Saha, Jayant Kumar Sah, Neeraj Saraf, Naveen Kumar, Sanjay Goja, Amit Rastogi, Prashant Bhangui, A S Soin
BACKGROUND: Cytomegalovirus (CMV) is the most common viral infection in liver transplant recipients that influences the outcomes of liver transplantation. However, its impact on early outcomes following living donor liver transplantation (LDLT) is not fully defined in the Indian subcontinent. This study was done to assess the impact of CMV infection on early post-transplant outcomes in LDLT recipients. METHODS: Out of 272 LDLTs performed from January 2012 to April 2013, 151 recipients underwent CMV viral load analysis in plasma within 90 days post LDLT based on clinical suspicion...
April 18, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29667992/naked-eye-and-electrochemical-detection-of-isothermally-amplified-hotair-long-non-coding-rna
#2
Md Nazmul Islam, Sofia Moriam, Muhammad Umer, Hoang-Phuong Phan, Carlos Salomon, Richard Kline, Nam-Trung Nguyen, Muhammad J A Shiddiky
An inexpensive, simple and rapid sensor platform capable of detecting cancer-related long non-coding RNA (lncRNA) with high accuracy is of great interest in the field of molecular diagnostics. Herein, we report on the development of a new colorimetric and electrochemical assay platform for long non-coding HOX transcript antisense intergenic RNA (HOTAIR) detection. Isothermal reverse transcription-recombinase polymerase amplification (RT-RPA) was performed to amplify HOTAIR sequences from a RNA pool extracted from a designated number of ovarian cancer cells and a small cohort of plasma samples derived from patients with ovarian cancer...
April 18, 2018: Analyst
https://www.readbyqxmd.com/read/29667913/ubiquitin-c-terminal-hydrolase-l1-deletion-is-associated-with-urinary-%C3%AE-klotho-deficiency-and-perturbed-phosphate-homeostasis
#3
Naomi C Boisvert, Chet E Holterman, Alexey Gutsol, Josee Coulombe, Wanling Pan, R Todd Alexander, Douglas A Gray, Chris R Kennedy
Loss of ubiquitin C-terminal hydrolase L1 (UCHL1), a deubiquitinating enzyme required for neuronal function, led to hyperphosphatemia accompanied by phosphaturia in mice, while calcium homeostasis remained intact. We therefore investigated the mechanisms underlying the phosphate imbalance in Uchl1-/- mice. Interestingly, phosphaturia was not a result of lower renal brush border membrane sodium-phosphate cotransporter expression as sodium-phosphate cotransporter 2a and 2c expression levels were similar to wild type levels...
April 18, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29667910/role-of-wnk4-and-kidney-specific-wnk1-in-mediating-the-effect-of-high-dietary-k-intake-on-romk-channel-in-the-distal-convoluted-tubule
#4
Peng Wu, Zhong-Xiuzi Gao, Xiao-Tong Su, David H Ellison, Juliette Hadchouel, Jacques Teulon, Wen-Hui Wang
With-no-lysine kinase 4 (WNK4) and kidney-Specific (KS)-WNK1 regulate ROMK (Kir1.1) channels in a variety of cell models. We now explore the role of WNK4 and KS-WNK1 in regulating ROMK in the native distal convoluted tubule (DCT)/connecting tubule (CNT) by measuring TPNQ (ROMK inhibitor)-sensitive K+ currents with whole-cell recording. TPNQ-sensitive K+ currents in DCT2/CNT of KS-WNK1-/- and WNK4-/- mice were significantly smaller than that of WT mice. In contrast, the basolateral K+ channels (a Kir4.1/5.1 heterotetramer) in the DCT were not inhibited...
April 18, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29667908/the-macula-densa-prorenin-receptor-is-essential-in-renin-release-and-blood-pressure-control
#5
Anne D M Riquier-Brison, Arnold Sipos, Ágnes Prókai, Sarah L Vargas, Ildiko Toma, Elliott J Meer, Karie G Villanueva, Jennifer C M Chen, Georgina Gyarmati, Christopher Yih, Elaine Tang, Bahram Nadim, Sujith Pendekanti, Ingrid M Garrelds, Genevieve Nguyen, A H Jan Danser, Janos Peti-Peterdi
The prorenin receptor (PRR) was originally proposed to be a member of the renin-angiotensin system (RAS), however recent work questioned their association. The present paper describes a functional link between the PRR and RAS in the renal juxtaglomerular apparatus (JGA), a classic anatomical site of the RAS. PRR expression was found in the sensory cells of the JGA, the macula densa (MD), and immunohistochemistry localized PRR to the MD basolateral cell membrane in mouse, rat, and human kidneys. MD cell PRR activation led to MAP kinase ERK1/2 signaling and stimulation of PGE2 release, the classic pathway of MD-mediated renin release...
April 18, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29667850/a-survey-of-fellowship-trained-upper-extremity-surgeons-on-treatment-of-lateral-epicondylitis
#6
Steven R Niedermeier, Nisha Crouser, Amy Speeckaert, Kanu S Goyal
BACKGROUND: The aim of the study is to investigate current management strategies for lateral epicondylitis by fellowship-trained upper extremity surgeons. METHODS: A 17-question survey of treatment approaches and outcomes related to lateral epicondylitis was sent to 3354 surgeons using the American Society for Surgery of the Hand and American Shoulder and Elbow Surgeons member databases. RESULTS: Six hundred twelve upper extremity surgeons completed the survey...
April 1, 2018: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29667843/standard-reference-line-combined-with-one-point-calibration-free-laser-induced-breakdown-spectroscopy-cf-libs-to-quantitatively-analyze-stainless-and-heat-resistant-steel
#7
Hongbo Fu, Huadong Wang, Junwei Jia, Zhibo Ni, Fengzhong Dong
Due to the influence of major elements' self-absorption, scarce observable spectral lines of trace elements, and relative efficiency correction of experimental system, accurate quantitative analysis with calibration-free laser-induced breakdown spectroscopy (CF-LIBS) is in fact not easy. In order to overcome these difficulties, standard reference line (SRL) combined with one-point calibration (OPC) is used to analyze six elements in three stainless-steel and five heat-resistant steel samples. The Stark broadening and Saha - Boltzmann plot of Fe are used to calculate the electron density and the plasma temperature, respectively...
January 1, 2018: Applied Spectroscopy
https://www.readbyqxmd.com/read/29667761/plant-glycosylphosphatidylinositol-gpi-anchored-proteins-at-the-plasma-membrane-cell-wall-nexus
#8
REVIEW
Trevor H Yeats, Antony Bacic, Kim L Johnson
Approximately 1% of plant proteins are predicted to be post-translationally modified with a glycosylphosphatidylinositol (GPI) anchor that tethers the polypeptide to the outer leaflet of the plasma membrane. While the synthesis and structure of GPI anchors is largely conserved across eukaryotes, the repertoire of functional domains present in the GPI-anchored proteome has diverged substantially. In plants, this includes a large fraction of the GPI-anchored proteome being further modified with plant-specific arabinogalactan (AG) O-glycans...
April 18, 2018: Journal of Integrative Plant Biology
https://www.readbyqxmd.com/read/29667759/incidence-predictors-and-clinical-management-of-hyperkalaemia-in-new-users-of-mineralocorticoid-receptor-antagonists
#9
Marco Trevisan, Pietro de Deco, Hairong Xu, Marie Evans, Bengt Lindholm, Rino Bellocco, Peter Barany, Tomas Jernberg, Lars H Lund, Juan J Carrero
BACKGROUND: Concerns for hyperkalaemia limit the use of mineralocorticoid receptor antagonists (MRAs). The frequency of MRA-associated hyperkalaemia in real-world settings and the extent of subsequent MRA discontinuation are poorly quantified. METHODS AND RESULTS: Observational study including all Stockholm citizens initiating MRA therapy during 2007-2010. Hyperkalaemias were identified from all potassium (K+ ) measurements in healthcare. MRA treatment lengths and dosages were obtained from complete collection of pharmacy dispensations...
April 18, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29667757/successful-treatment-with-nivolumab-for-lung-cancer-with-low-expression-of-pd-l1-and-prominent-tumor-infiltrating-b-cells-and-immunoglobulin-g
#10
Takayuki Suyama, Yuichi Fukuda, Hiroshi Soda, Daiki Ogawara, Keisuke Iwasaki, Takuya Hara, Masataka Yoshida, Tatsuhiko Harada, Asuka Umemura, Hiroyuki Yamaguchi, Hiroshi Mukae
Little is known about the anti-tumor activity of humoral immunity in lung cancer patients treated with nivolumab, an immune checkpoint inhibitor. Herein, we report a case of lung cancer with 5% expression of PD-L1, in which a partial response to nivolumab was sustained for > 7 months. Immunohistochemical analysis of the metastatic lymph node biopsy specimen showed prominent accumulation of plasma cells and immunoglobulin G. These findings suggest that pre-existing humoral immunity may be worth considering as a candidate therapeutic biomarker of nivolumab in some lung cancer patients...
April 18, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29667754/estrogen-regulated-expression-of-p450arom-genes-in-the-brain-and-ovaries-of-adult-female-indian-climbing-perch-anabas-testudineus
#11
Puja Pal, Sujata Roy Moulik, Shreyasi Gupta, Payel Guha, Suravi Majumder, Sourav Kundu, Buddhadev Mallick, Kousik Pramanick, Dilip Mukherjee
Cytochrome P450arom (CYP19), a product of cyp19a1 gene, catalyzes the conversion of androgens to estrogens and is essential for regulation of reproductive function in vertebrates. In the present study, we isolated partial cDNA encoding the ovarian (cyp19a1a) and brain (cyp19a1b) P450arom genes from adult female perch, Anabas testudineus and investigated their regulation by estrogen in vivo. Results demonstrated that cyp19a1a and cyp19a1b predominate in ovary and brain respectively, with quantity of both attuned to reproductive cycle...
April 18, 2018: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
https://www.readbyqxmd.com/read/29667735/beyond-voltage-gated-ion-channels-voltage-operated-membrane-proteins-and-cellular-processes
#12
REVIEW
Jianping Zhang, Xingjuan Chen, Yucong Xue, Nikita Gamper, Xuan Zhang
Voltage-gated ion channels were believed to be the only voltage-sensitive proteins in excitable (and some non-excitable) cells for a long time. Emerging evidence indicates that the voltage-operated model is shared by some other transmembrane proteins expressed in both excitable and non-excitable cells. In this review, we summarize current knowledge about voltage-operated proteins, which are not classic voltage-gated ion channels as well as the voltage-dependent processes in cells for which single voltage-sensitive proteins have yet to be identified...
April 18, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29667734/celastrol-reverses-palmitic-acid-pa-caused-tlr4-md2-activation-dependent-insulin-resistance-via-disrupting-md2-related-cellular-binding-to-pa
#13
Xue Zhang, Ying Wang, Hui-Ya Ge, Yi-Jun Gu, Fan-Fan Cao, Chun-Xin Yang, Georges Uzan, Bin Peng, Deng-Hai Zhang
Elevated plasma statured fatty acids (FFAs) cause TLR4/MD2 activation-dependent inflammation and insulin tolerance, which account for the occurrence and development of obesity. It has been confirmed that statured palmitic acid (PA) (the most abundant FFA) could bind MD2 to cause cellular inflammation. The natural compound celastrol could improve obesity, which is suggested via inhibiting inflammation, yet the detailed mechanism for celastrol is still unclear. As celastrol is reported to directly target MD2, we thought disrupting the binding between FFAs and MD2 might be one of the ways for celastrol to inhibit FFAs-caused inflammation and insulin resistance...
April 18, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29667599/sensitive-singular-phase-optical-detection-without-phase-measurements-with-tamm-plasmons
#14
Svetlana V Boriskina, Yoichiro Tsurimaki
Spectrally-tailored interactions of light with material interfaces offer many exciting applications in sensing, photo-detection, and optical energy conversion. In particular, complete suppression of light reflectance at select frequencies accompanied by sharp phase variations in the reflected signal forms the basis for the development of ultra-sensitive singular-phase optical detection schemes such as Brewster and surface plasmon interferometry. However, both the Brewster effect and surface-plasmon-mediated absorption on planar interfaces are limited to one polarization of the incident light and oblique excitation angles, and may have limited bandwidth dictated by the material dielectric index and plasma frequency...
April 18, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29667572/neurobiological-findings-associated-with-high-cognitive-performance-in-older-adults-a-systematic-review
#15
Wyllians Vendramini Borelli, Lucas Porcello Schilling, Graciane Radaelli, Luciana Borges Ferreira, Leonardo Pisani, Mirna Wetters Portuguez, Jaderson Costa da Costa
ABSTRACTObjectives:to perform a comprehensive literature review of studies on older adults with exceptional cognitive performance. DESIGN: We performed a systematic review using two major databases (MEDLINE and Web of Science) from January 2002 to November 2017. RESULTS: Quantitative analysis included nine of 4,457 studies and revealed that high-performing older adults have global preservation of the cortex, especially the anterior cingulate region, and hippocampal volumes larger than normal agers...
April 18, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29667558/ga-68-nanoparticles-and-ultra-small-nanoparticle-next-generation-of-pet-radiopharmaceuticals
#16
Mohammed Al-Qahtani, Yousif Al Malki, Hadeel Mutwali, Edward Helal-Neto, Ralph Santos-Oliveira
BACKGROUND AND OBJECTIVE: The future of medicine relies on the capability to forecast the future and in the development of new drugs. The same rationale is applied to radiopharmacy. In this direction the development of nano-radiopharmaceuticals represents the most effective glance of the future. METHODS: In this manuscript we developed an efficient, rapid and direct methodology to label ultra-small polymeric nanoparticle (10 to 12 nm) and regular polymeric nanoparticles (200 to 210 nm), both obtained by double emulsion technique, with Ga-68 in order to promote the development of PET-nanoradiopharmaceuticals...
April 17, 2018: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/29667546/seminal-supar-levels-as-marker-of-abacterial-male-accessory-gland-inflammation-in-hypogonadism
#17
Domenico Milardi, Giuseppe Grande, Chiara Autilio, Francesca Mancini, Laura De Marinis, Riccardo Marana, Cecilia Zuppi, Andrea Urbani, Alfredo Pontecorvi, Silvia Baroni
Recent evidences suggest that hypogonadism is an important risk factor for lower urinary tract symptoms and benign prostatic hyperplasia. Several papers have discussed the role of chronic inflammation in the development of BPH, which may be modulated by the hypogonadal state. Soluble urokinase-type plasminogen activator receptor (suPAR), known protein marker of systemic inflammation, can be assayed in the seminal plasma and represents a reliable and sensitive marker of inflammation for the male accessory gland inflammation (MAGI)...
April 18, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29667485/amino-acid-kinetics-and-the-response-to-nutrition-in-patients-with-cancer
#18
Barbara S van der Meij, Laisa Teleni, Marielle Pkj Engelen, Nicolaas Ep Deutz
PURPOSE: Amino acids are involved in many physiological processes in the body and serve as building blocks of proteins which are the main component of muscle mass. Often patients with cancer experience muscle wasting, which is associated with poor outcomes. The purpose of this paper is to discuss amino acid kinetics in cancer, review the evidence on the response to nutrition in patients with cancer, and to give recommendations on the appropriate level of amino acid or protein intake in cancer...
April 18, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29667462/glucosamine-for-the-treatment-of-osteoarthritis-the-time-has-come-for-higher-dose-trials
#19
Mark F McCarty, James H O'Keefe, James J DiNicolantonio
Although clinical trials with glucosamine in osteoarthritis have yielded mixed results, leading to doubts about its efficacy, the utility of glucosamine for preventing joint destruction and inflammation is well documented in rodent models of arthritis, including models of spontaneous osteoarthritis. The benefit of oral glucosamine in adjuvant arthritis is markedly dose dependent, likely reflecting a modulation of tissue levels of UDP-N-acetylglucosamine that in turn influences mucopolysaccharide synthesis and the extent of protein O-GlcNAcylation...
April 18, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29667449/predicting-rapid-analgesic-onset-of-ibuprofen-salts-compared-with-ibuprofen-acid-t-lag-t-low-t-med-and-a-novel-parameter-t-cmaxref
#20
Lisa Miles, Jessica Hall, Bartosz Jenner, Richard Addis, Simon Hutchings
OBJECTIVE: This study evaluated the early absorption characteristics of ibuprofen salt formulations and standard ibuprofen acid (the reference). METHODS: In this open-label, crossover, single-center study (NCT02452450) in 32 healthy, fasted adults receiving single oral doses (400 mg ibuprofen) of ibuprofen lysine, ibuprofen liquid capsule, ibuprofen sodium, ibuprofen acid, and paracetamol, intensive blood sampling was conducted for up to 6 hours. Time between dosing and the start of absorption (Tlag ); a novel parameter, time at which the test formulations (ibuprofen salts) reached the observed maximum plasma concentration (Cmax ) of the reference (standard ibuprofen acid) (TCmaxRef ); and time to achieve therapeutic plasma concentration were measured...
April 18, 2018: Current Medical Research and Opinion
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