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https://www.readbyqxmd.com/read/27797160/pathogenesis-of-central-and-complex-sleep-apnoea
#1
REVIEW
Jeremy E Orr, Atul Malhotra, Scott A Sands
Central sleep apnoea (CSA) - the temporary absence or diminution of ventilatory effort during sleep - is seen in a variety of forms including periodic breathing in infancy and healthy adults at altitude and Cheyne-Stokes respiration in heart failure. In most circumstances, the cyclic absence of effort is paradoxically a consequence of hypersensitive ventilatory chemoreflex responses to oppose changes in airflow, that is elevated loop gain, leading to overshoot/undershoot ventilatory oscillations. Considerable evidence illustrates overlap between CSA and obstructive sleep apnoea (OSA), including elevated loop gain in patients with OSA and the presence of pharyngeal narrowing during central apnoeas...
October 31, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27707442/nasal-dilator-strip-is-an-effective-placebo-intervention-for-severe-obstructive-sleep-apnea
#2
Fabiana Yagihara, Geraldo Lorenzi-Filho, Rogerio Santos-Silva
STUDY OBJECTIVES: The aim of this study was to evaluate the effects of nasal dilator strip (NDS) as a placebo intervention compared with continuous positive airway pressure (CPAP) treatment in patients with severe obstructive sleep apnea (OSA). METHODS: Patients were treated with both NDS and nasal CPAP. The sequence was randomized and interposed by 15 days of washout. Polysomnography was performed at baseline and on the first night of intervention with NDS and CPAP (titration)...
September 29, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/27583668/residual-excessive-sleepiness-in-patients-with-obstructive-sleep-apnea-on-treatment-with-continuous-positive-airway-pressure
#3
Eptehal M Dongol, Adrian J Williams
PURPOSE OF REVIEW: One of the most common causes of excessive daytime sleepiness in clinical practice is obstructive sleep apnea syndrome (OSAS). So far, continuous positive airway pressure (CPAP) is the most effective treatment for OSA. Some of the patients do not improve on CPAP and remain sleepy despite using CPAP.This review provides updated information about the possible causes of residual sleepiness whilst using the CPAP in patients with OSAS. RECENT FINDINGS: Prevalence of OSAS has increased recently to 23...
November 2016: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/27334512/upper-airway-variation-and-frequent-alcohol-consumption-can-affect-compliance-with-continuous-positive-airway-pressure
#4
Jong In Jeong, Hyo Yeol Kim, Sang Duk Hong, Gwanghui Ryu, Su Jin Kim, Kyung Eun Lee, Hun-Jong Dhong, Seung-Kyu Chung
OBJECTIVES: Compliance with continuous positive airway pressure (CPAP) treatment remains a primary concern for improving treatment outcomes of obstructive sleep apnea. There are few studies that have considered the role of upper airway anatomy on the compliance with CPAP. We hypothesized that upper airway anatomy would influence the compliance with CPAP. METHODS: One hundred out of 161 consecutive patients were enrolled in this study. The following possible determinants were tested against CPAP use: demographic and anthropometric data, minimal cross-sectional area on acoustic rhinometry, cephalometric and polysomnographic data, questionnaires of Epworth sleepiness scale and Beck depression index, and histories of previous upper airway surgery, degree of nasal obstruction, daily cigarette consumption, and weekly frequency of alcohol intake...
December 2016: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/27181196/continuous-positive-airway-pressure-improves-quality-of-life-in-women-with-osa-a-randomized-controlled-trial
#5
Francisco Campos-Rodriguez, Carlos Queipo-Corona, Carmen Carmona-Bernal, Bernabe Jurado-Gamez, Jose Cordero-Guevara, Nuria Reyes-Nuñez, Fernanda Troncoso-Acevedo, Araceli Abad-Fernandez, Joaquin Teran-Santos, Julian Caballero-Rodriguez, Mercedes Martin-Romero, Ana Encabo-Motiño, Lirios Sacristan-Bou, Javier Navarro-Esteva, Maria Somoza-Gonzalez, Juan F Masa, Maria A Sanchez-Quiroga, Beatriz Jara-Chinarro, Belen Orosa-Bertol, Miguel A Martinez-Garcia
RATIONALE: Continuous positive airway pressure (CPAP) is the treatment of choice in patients with symptomatic obstructive sleep apnea (OSA). CPAP improves quality of life (QoL) in men with OSA but its role in women has not yet been assessed. OBJECTIVE: To investigate the effect of CPAP on QoL in women with moderate-to-severe OSA. METHODS: Multicenter, open-label, randomized controlled trial conducted in 307 consecutive women diagnosed with moderate-to-severe OSA (apnea-hypopnea index [AHI] ≥15) in 19 Spanish Sleep Units...
May 15, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27171827/continuous-positive-airway-pressure-mitigates-opioid-induced-worsening-of-sleep-disordered-breathing-early-after-bariatric-surgery
#6
Sebastian Zaremba, Christina H Shin, Matthew M Hutter, Sanjana A Malviya, Stephanie D Grabitz, Teresa MacDonald, Daniel Diaz-Gil, Satya Krishna Ramachandran, Dean Hess, Atul Malhotra, Matthias Eikermann
BACKGROUND: Bariatric surgery patients are vulnerable to sleep-disordered breathing (SDB) early after recovery from surgery and anesthesia. The authors hypothesized that continuous positive airway pressure (CPAP) improves postoperative oxygenation and SDB and mitigates opioid-induced respiratory depression. METHODS: In a randomized crossover trial, patients after bariatric surgery received 30% oxygen in the postanesthesia care unit (PACU) under two conditions: atmospheric pressure and CPAP (8 to 10 cm H2O)...
July 2016: Anesthesiology
https://www.readbyqxmd.com/read/27075687/efficacy-of-daytime-transcutaneous-electrical-stimulation-of-the-genioglossus-muscle-in-patients-with-obstructive-sleep-apnea-syndrome-short-report
#7
Sylwia Chwieśko-Minarowska, Łukasz Minarowski, Wojciech Aleksander Szewczak, Elżbieta Chyczewska, Anna Kuryliszyn-Moskal
Obstructive sleep apnea syndrome (OSAS) is characterized by hypotonia of lingual and suprahyoid muscles. Genioglossus muscle is responsible for protrusion and depression of the tongue. Its dysfunction results in occlusion of the upper airways and greater incidence of apnea-hypopnea events during sleep. The aim of this prospective study was to compare the effects of daytime transcutaneous electrical stimulation of the genioglossus muscle and standard continuous positive airway pressure (CPAP) therapy on the quality of sleep, in patients with OSAS...
April 13, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/26998379/respiratory-support-for-pharmacologically-induced-hypoxia-in-neonatal-calves
#8
C G Donnelly, C T Quinn, S G Nielsen, S L Raidal
Practical methods to provide respiratory support to bovine neonates in a field setting are poorly characterised. This study evaluated the response of healthy neonatal calves with pharmacologically induced respiratory suppression to nasal oxygen insufflation and to continuous positive airway pressure (CPAP) delivered via an off-the-shelf device. Ten calves were randomised to receive either nasal oxygen insufflation (Group 1, n = 5) or CPAP (Group 2, n = 5) as a first treatment after induction of respiratory depression by intravenous administration of xylazine, fentanyl, and diazepam...
2016: Veterinary Medicine International
https://www.readbyqxmd.com/read/26265560/a-pathway-underlying-the-impact-of-cpap-adherence-on-intimate-relationship-with-bed-partner-in-men-with-obstructive-sleep-apnea
#9
Agnes Y K Lai, Mary S M Ip, Jamie C M Lam, Terri E Weaver, Daniel Y T Fong
PURPOSE: Our aim was to determine the pathway underlying the effects of continuous positive airway pressure (CPAP) adherence on intimate relationship with bed partner in men with obstructive sleep apnea (OSA). We hypothesized that CPAP with good adherence affected the intimate relationship with bed partner directly and indirectly, and it was mediated through daytime sleepiness and activity level in men with OSA. METHODS: Data were obtained from an education program for enhancing CPAP adherence...
May 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/26156890/comorbid-depression-in-obstructive-sleep-apnea-an-under-recognized-association
#10
REVIEW
Ahmed S BaHammam, Tetyana Kendzerska, Ravi Gupta, Chellamuthu Ramasubramanian, David N Neubauer, Meera Narasimhan, Seithikurippu R Pandi-Perumal, Adam Moscovitch
BACKGROUND: Obstructive sleep apnea (OSA) and depression may coexist in the same patient. This article aims to review the link between OSA and comorbid depression and critically evaluate the results of studies that assessed the correlation between OSA and depression, the impact of OSA treatment on comorbid depression, and the impact of comorbid depression on continuous positive airway pressure (CPAP) adherence. METHODS: An integrative review was conducted on English language studies and reports that assessed the relationship between OSA and depression...
May 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/26022945/obstructive-sleep-apnoea-in-the-elderly-role-of-continuous-positive-airway-pressure-treatment
#11
RANDOMIZED CONTROLLED TRIAL
Miguel Ángel Martínez-García, Eusebi Chiner, Luis Hernández, Jose Pascual Cortes, Pablo Catalán, Silvia Ponce, Jose Ramón Diaz, Ester Pastor, Laura Vigil, Carmen Carmona, Josep Maria Montserrat, Felipe Aizpuru, Patricia Lloberes, Mercedes Mayos, Maria José Selma, Jose Fernando Cifuentes, Alvaro Muñoz
Almost all the information about the effect of continuous positive airway pressure (CPAP) in patients with obstructive sleep apnoea (OSA) comes from clinical trials involving only middle-aged patients. The objective of this study was to assess the effect of CPAP treatment in elderly patients with severe OSA on clinical, quality-of-life and neurocognitive spheres. We performed an open-label, randomised, multicentre clinical trial in a consecutive clinical cohort of 224 elderly (≥70 years old) patients with confirmed severe OSA (apnoea-hypopnea index ≥30) randomised to receive CPAP (n=115) or no CPAP (n=109) for 3 months...
July 2015: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/25946388/chapter-8-military-personnel-with-traumatic-brain-injuries-and-insomnia-have-reductions-in-ptsd-and-improved-perceived-health-following-sleep-restoration-a-relationship-moderated-by-inflammation
#12
Taura Barr, Whitney Livingston, Pedro Guardado, Tristin Baxter, Vincent Mysliwiec, Jessica Gill
BACKGROUND: Up to one-third of deployed military personnel sustain a traumatic brain injury (TBI). TBIs and the stress of deployment contribute to the vulnerability for chronic sleep disturbance, resulting in high rates of insomnia diagnoses as well as symptoms of posttraumatic stress disorder (PTSD), depression, and declines in health-related quality of life (HRQOL). Inflammation is associated with insomnia; however, the impact of sleep changes on comorbid symptoms and inflammation in this population is unknown...
2015: Annual Review of Nursing Research
https://www.readbyqxmd.com/read/25902824/depressive-symptoms-before-and-after-treatment-of-obstructive-sleep-apnea-in-men-and-women
#13
Cass Edwards, Sutapa Mukherjee, Laila Simpson, Lyle J Palmer, Osvaldo P Almeida, David R Hillman
STUDY OBJECTIVES: To determine prevalence of depressive symptoms in obstructive sleep apnea (OSA) and the impact of OSA treatment on depression scores. METHODS: Consecutive new patients referred for investigation of suspected OSA were approached. Consenting patients completed a patient health questionnaire (PHQ-9) for depressive symptoms when attending for laboratory polysomnography. Those with moderate/severe (apneahypopnea index [AHI] ≥ 15 events/h) and/or symptomatic mild OSA (AHI 5-14...
September 15, 2015: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/25876002/effects-of-nasal-continuous-positive-airway-pressure-therapy-on-partners-sexual-lives
#14
Mustafa Acar, Coskun Kaya, Tolgahan Catli, Deniz Hancı, Ozge Bolluk, Yunus Aydin
To assess sexual functioning in male and female partners before and after nasal continuous positive airway pressure (CPAP) therapy in men with obstructive sleep apnea (OSA). Twenty-one male patients with moderate to severe OSA and erectile dysfunction, and their female partner, were recruited into this prospective study. Males diagnosed with OSA were treated with nasal CPAP therapy for 12 weeks. Women were assessed for sexual functioning using the Female Sexual Function Index (FSFI), and for mood status using the Beck Depression Inventory (BDI), before and after their male partner underwent nasal CPAP therapy...
January 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/25834546/obstructive-sleep-apnea-syndrome-and-erectile-dysfunction-does-long-term-continuous-positive-airway-pressure-therapy-improve-erections
#15
Tokgoz Husnu, Akyurek Ersoz, Erol Bulent, Ornek Tacettin, Altin Remzi, Akduman Bulent, Mungan Aydin
OBJECTIVES: The aim of this age-matched, controlled, prospective clinical study was to investigate frequency and degree of erectile dysfunction (ED) in patients with obstructive sleep apnea syndrome (OSAS) and to evaluate the results of only continuous positive airway pressure (CPAP) therapy on ED in patients with OSAS. MATERIALS AND METHODS: A total of 90 patients were evaluated for potential OSAS. They were given an International Index of Erectile Function questionnaire (IIEF) and Beck Depression Inventory...
March 2015: African Health Sciences
https://www.readbyqxmd.com/read/25789439/pain-and-sleep-in-post-concussion-mild-traumatic-brain-injury
#16
REVIEW
Gilles Lavigne, Samar Khoury, Jean-Marc Chauny, Alex Desautels
Concussion after a force to the head is called mild traumatic brain injury (mTBI). Approximately 1 in 5 patients with mTBI will develop chronic pain (headache and widespread pain, possibly of central origin) and/or sleep problems (insomnia, disordered breathing, periodic limb movements). However, the predisposing mechanisms for chronic pain in patients with mTBI are unknown. Mild traumatic brain injury is a rare model to prospectively assess the risk factors and mechanisms for pain chronification from the injury onset in the absence of pretrauma comorbidity or medication...
April 2015: Pain
https://www.readbyqxmd.com/read/25423175/effect-of-treatment-of-obstructive-sleep-apnea-on-depressive-symptoms-systematic-review-and-meta-analysis
#17
REVIEW
Marcus Povitz, Carmelle E Bolo, Steven J Heitman, Willis H Tsai, JianLi Wang, Matthew T James
BACKGROUND: Obstructive sleep apnea (OSA) is associated with increased morbidity and mortality, and decreased quality of life. Treatment with continuous positive airway pressure (CPAP) or mandibular advancement devices (MADs) is effective for many symptoms of OSA. However, it remains controversial whether treatment with CPAP or MAD also improves depressive symptoms. METHODS AND FINDINGS: We performed a systematic review and meta-analysis of randomized controlled trials that examined the effect of CPAP or MADs on depressive symptoms in patients with OSA...
November 2014: PLoS Medicine
https://www.readbyqxmd.com/read/25406268/obstructive-sleep-apnea-and-psychiatric-disorders-a-systematic-review
#18
REVIEW
Madhulika A Gupta, Fiona C Simpson
STUDY OBJECTIVES: Obstructive sleep apnea (OSA) has been associated with psychiatric pathology. Psychiatric comorbidity in OSA may affect patient quality of life and adherence to CPAP. A focused evaluation of OSA in highly selected groups of primarily psychiatric patients may provide further insights into the factors contributing to comorbidity of OSA and psychopathology. The goal of this study is to examine the prevalence and treatment of OSA in psychiatric populations. METHODS: A systematic review following the PRISMA guidelines was conducted to determine the prevalence of OSA in schizophrenia and other psychotic disorders, mood disorders, and anxiety disorders, and to examine potential interventions...
February 15, 2015: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/25334582/effect-of-pap-compliance-on-sexual-quality-of-life
#19
Salman Alim, Rashid Nadeem, Imtiaz Kadri, Sipan Mathevosian, Vinod Khatri, Jose Antony Paul, Ahmet Copur, Ashok Fulambarker
Quality & Clinical Improvement ISESSION TYPE: Original Investigation SlidePRESENTED ON: Sunday, October 26, 2014 at 04:30 PM - 05:30 PMPURPOSE: Erectile Dysfunction (ED) is highly prevalent (22-64%) in obstructive sleep apnea (OSA) patients. Previous studies have reported improvement of ED with treatment of OSA with positive airway pressure (PAP) therapy. However, patients using PAP may find themselves less sexually attractive when they picture themselves with a hose and mask, PAP use may also interfere with foreplay...
October 1, 2014: Chest
https://www.readbyqxmd.com/read/25325491/psychometric-performance-and-responsiveness-of-the-functional-outcomes-of-sleep-questionnaire-and-sleep-apnea-quality-of-life-instrument-in-a-randomized-trial-the-homepap-study
#20
RANDOMIZED CONTROLLED TRIAL
Martha E Billings, Carol L Rosen, Dennis Auckley, Ruth Benca, Nancy Foldvary-Schaefer, Conrad Iber, Phyllis C Zee, Susan Redline, Vishesh K Kapur
STUDY OBJECTIVES: Measures of health-related quality of life (HRQL) specific for sleep disorders have had limited psychometric evaluation in the context of randomized controlled trials (RCTs). We investigated the psychometric properties of the Functional Outcomes of Sleep Questionnaire (FOSQ) and Sleep Apnea Quality of Life Instrument (SAQLI). We evaluated the FOSQ and SAQLI construct and criterion validity, determined a minimally important difference, and assessed for associations of responsiveness to baseline subject characteristics and continuous positive airway pressure (CPAP) adherence in a RCT population...
December 1, 2014: Sleep
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