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https://www.readbyqxmd.com/read/29781587/patients-concerns-and-perceptions-regarding-biologic-therapies-in-ankylosing-spondylitis-insights-from-a-large-scale-survey-of-social-media-platforms
#1
Eldin Dzubur, Carine Khalil, Christopher V Almario, Benjamin Noah, Deeba Minhas, Mariko Ishimori, Corey Arnold, Yujin Park, Jonathan Kay, Michael H Weisman, Brennan M R Spiegel
OBJECTIVE: Few studies have examined ankylosing spondylitis (AS) patients' concerns and perceptions of biologic therapies outside of traditional surveys. In this study, we used social media data to examine AS patients' knowledge, attitudes, and beliefs regarding biologic therapies. METHODS: We collected posts from 601 social media sites made between 1/1/06-4/26/17. Each post mentioned both an AS keyword and a biologic. To explore themes within the collection in an unsupervised manner, a latent Dirichlet allocation topic model was fit to the dataset...
May 21, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29770477/braf-v-600e-mutations-and-immunohistochemical-expression-of-ve1-protein-in-low-grade-serous-neoplasms-of-the-ovary
#2
Gulisa Turashvili, Rachel N Grisham, Sarah Chiang, Deborah F Delair, Kay J Park, Robert A Soslow, Rajmohan Murali
AIMS: The most common BRAF mutation in ovarian low-grade serous neoplasms (LGSNs) involves substitution of valine by glutamic acid at position 600 (V600E). Small studies have demonstrated high specificity of immunohistochemistry with mutation-specific monoclonal antibody VE1. We sought to investigate expression of VE1 protein in LGSNs and its correlation with BRAF mutation-associated histological features and BRAF mutation status. METHODS AND RESULTS: We reviewed pathology reports and available slides from ovarian serous borderline tumours (SBTs) and low-grade serous carcinomas (LGSCs) diagnosed between 2000-2012...
May 16, 2018: Histopathology
https://www.readbyqxmd.com/read/29765038/quantifying-climate-feedbacks-in-polar-regions
#3
REVIEW
Hugues Goosse, Jennifer E Kay, Kyle C Armour, Alejandro Bodas-Salcedo, Helene Chepfer, David Docquier, Alexandra Jonko, Paul J Kushner, Olivier Lecomte, François Massonnet, Hyo-Seok Park, Felix Pithan, Gunilla Svensson, Martin Vancoppenolle
The concept of feedback is key in assessing whether a perturbation to a system is amplified or damped by mechanisms internal to the system. In polar regions, climate dynamics are controlled by both radiative and non-radiative interactions between the atmosphere, ocean, sea ice, ice sheets and land surfaces. Precisely quantifying polar feedbacks is required for a process-oriented evaluation of climate models, a clear understanding of the processes responsible for polar climate changes, and a reduction in uncertainty associated with model projections...
May 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29750702/morphologic-features-of-gastric-type-cervical-adenocarcinoma-in-small-surgical-and-cytology-specimens
#4
Gulisa Turashvili, Elizabeth G Morency, Mihaela Kracun, Deborah F DeLair, Sarah Chiang, Robert A Soslow, Kay J Park, Rajmohan Murali
Gastric-type cervical adenocarcinoma (GCA) is a human papillomavirus-unassociated, aggressive, chemorefractory tumor. Well-differentiated examples may exhibit bland morphologic appearances, which could potentially lead to misdiagnosis, particularly in limited material. We sought to characterize the morphologic features of GCA in surgical biopsy and cytology specimens. We identified patients with histologic diagnoses of GCA or minimal-deviation adenocarcinoma between 2004 and 2017. Available slides from biopsy, curettage, and cytology specimens were reviewed...
May 10, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29672399/minimally-invasive-lobectomy-is-associated-with-lower-noncancer-specific-mortality-in-elderly-patients-a-propensity-score-matched-competing-risks-analysis
#5
Boris Hristov, Takashi Eguchi, Sarina Bains, Joe Dycoco, Kay See Tan, James M Isbell, Bernard J Park, David R Jones, Prasad S Adusumilli
OBJECTIVE: To investigate cancer- and noncancer-specific mortality following lobectomy by minimally invasive surgery (MIS) versus open thoracotomy in elderly patients with nonsmall cell lung cancer (NSCLC). BACKGROUND: Two-thirds of patients with NSCLC are ≥65 years of age. As age increases, the risk of competing events, such as noncancer death, also increases. METHODS: Elderly patients (≥65 yrs of age) who have undergone curative-intent lobectomy for stage I-III NSCLC without induction therapy (2002-2013) were included (n=1,303)...
April 18, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29667874/evaluation-of-a-test-and-cull-strategy-for-reducing-prevalence-of-chronic-wasting-disease-in-mule-deer-odocoileus-hemionus
#6
Lisa L Wolfe, Mary Kay Watry, Michael A Sirochman, Tracey M Sirochman, Michael W Miller
  We evaluated a test and cull strategy for lowering chronic wasting disease (CWD) prevalence in a naturally-infected, free-ranging mule deer ( Odocoileus hemionus) herd wintering in the town of Estes Park, Colorado, USA and in nearby Rocky Mountain National Park. We tested 48-68% of the estimated number of adult (≥1 yr old) deer annually for 5 yr via tonsil biopsy immunohistochemistry (IHC), collecting 1,251 samples from >700 individuals and removing IHC-positive deer. Among males, CWD prevalence during the last 3 yr of selective culling was lower (one-sided Fisher's exact test P=0...
April 18, 2018: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29619213/pet-owner-and-vet-interactions-exploring-the-drivers-of-amr
#7
Matt Smith, Caroline King, Mark Davis, Adele Dickson, Jeni Park, Fraser Smith, Kay Currie, Paul Flowers
Background: Antimicrobial resistance (AMR) is a growing public health problem across the world. As the negative consequences of AMR become apparent at local, national and international levels, more attention is being focussed on the variety of mechanisms by which AMR is potentiated. We explore how interactions between pet owners and veterinarians represent a key arena in which AMR-related behaviours can be shaped. Methods: In depth semi-structured interviews were carried out with pet owners ( n  = 23) and vets ( n  = 16) across the UK in 2017...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29599409/functional-precision-medicine-identifies-novel-druggable-targets-and-therapeutic-options-in-head-and-neck-cancer
#8
Chang Xu, Olga Nikolova, Ryan S Basom, Ryan M Mitchell, Reid Shaw, Russell D Moser, Heuijoon Park, Kay E Gurley, Michael C Kao, Carlos L Green, Franz X Schaub, Robert L Diaz, Hallie A Swan, In S Jang, Justin Guinney, Vijayakrishna K Gadi, Adam A Margolin, Carla Grandori, Christopher J Kemp, Eduardo Méndez
Purpose: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, with high mortality and a lack of targeted therapies. To identify and prioritize druggable targets, we performed genome analysis together with genome-scale siRNA and oncology drug profiling using low-passage tumor cells derived from a patient with treatment-resistant HPV-negative HNSCC. Experimental Design: A tumor cell culture was established and subjected to whole-exome sequencing, RNA sequencing, comparative genome hybridization, and high-throughput phenotyping with a siRNA library covering the druggable genome and an oncology drug library...
March 29, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29596818/clinical-outcomes-of-root-reimplantation-and-bentall-procedure-propensity-score-matching-analysis
#9
Heemoon Lee, Yang Hyun Cho, Kiick Sung, Wook Sung Kim, Kay-Hyun Park, Dong Seop Jeong, Pyo Won Park, Young Tak Lee
BACKGROUND: This study aimed to evaluate the clinical outcomes of aortic root replacement(ARR) surgery:Root reimplantation as valve-sparing root replacement(VSR) and the Bentall procedure. METHODS: We retrospectively reviewed 216 patients who underwent ARR between 1995 and 2013 at Samsung Medical Center. Patients were divided into two groups, depending on the procedure they underwent: Bentall(n=134) and VSR(n=82). The mean follow-up duration was 100.9±56.4 months...
March 26, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29575152/assessing-the-release-of-copper-from-nanocopper-treated-and-conventional-copper-treated-lumber-into-marine-waters-1-concentrations-and-rates
#10
Ashley N Parks, Mark G Cantwell, David R Katz, Michaela A Cashman, Todd P Luxton, Kay T Ho, Robert M Burgess
Little is known about the release of metal engineered nanomaterials (ENMs) from consumer goods including lumber treated with micronized copper. Micronized copper is a recent form of anti-fouling wood preservative containing nano-sized copper particles for use in pressure treated lumber. This study investigated the concentrations released and release rate of total copper over 133 days under freshwater, estuarine, and marine salinity conditions (0, 1, 10, and 30‰) for several commercially available pressure treated lumbers: micronized copper azole (MCA) at 0...
March 25, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29575127/assessing-the-release-of-copper-from-nanocopper-treated-and-conventional-copper-treated-lumber-into-marine-waters-2-forms-and-bioavailability
#11
Ashley N Parks, Mark G Cantwell, David R Katz, Michaela A Cashman, Todd P Luxton, Justin G Clar, Monique M Perron, Lisa Portis, Kay T Ho, Robert M Burgess
One application of nanocopper is as a wood-preserving pesticide in pressure treated lumber. Recent research has shown that pressure treated lumber amended with micronized copper azole (MCA), which contains nano-sized copper, releases copper under estuarine and marine conditions. The form of copper released (i.e., ionic, nanocopper (1 to 100 nm in size)) is not fully understood but will affect the bioavailability and toxicity of the metal. In this investigation, multiple lines of evidence, including size fractionation, ion selective electrode (ISE) electrochemistry, comparative toxicity, and copper speciation were used to determine the form of copper released from lumber blocks and sawdust...
March 25, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29553955/ntrk-fusions-define-a-novel-uterine-sarcoma-subtype-with-features-of-fibrosarcoma
#12
Sarah Chiang, Paolo Cotzia, David M Hyman, Alexander Drilon, William D Tap, Lei Zhang, Jaclyn F Hechtman, Denise Frosina, Achim A Jungbluth, Rajmohan Murali, Kay J Park, Robert A Soslow, Esther Oliva, A John Iafrate, Ryma Benayed, Marc Ladanyi, Cristina R Antonescu
Tropomyosin receptor kinase (Trk) inhibitors have shown high response rates in patients with tumors harboring NTRK fusions. We identified 4 NTRK fusion-positive uterine sarcomas that should be distinguished from leiomyosarcoma and undifferentiated uterine sarcoma. NTRK rearrangements were detected by fluorescence in situ hybridization (FISH) and/or targeted RNA or DNA sequencing in 4 undifferentiated uterine sarcomas with spindle cell morphology. Because of histologic overlap with leiomyosarcoma, TrkA and pan-Trk immunohistochemistry was performed in 97 uterine leiomyosarcomas...
June 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29550207/safety-and-feasibility-of-lung-resection-after-immunotherapy-for-metastatic-or-unresectable-tumors
#13
Matthew J Bott, Jonathan Cools-Lartigue, Kay See Tan, Joseph Dycoco, Manjit S Bains, Robert J Downey, James Huang, James M Isbell, Daniela Molena, Bernard J Park, Valerie W Rusch, Smita Sihag, David R Jones, Prasad S Adusumilli
BACKGROUND: Surgeons are increasingly asked to operate on patients with residual disease after immunotherapy. The safety and utility of lung resection in this setting are unknown. METHODS: We performed a retrospective review of patients who underwent lung resection within 6 months of treatment with checkpoint blockade agents for metastatic or unresectable cancer. Survival was estimated from first resection using the Kaplan-Meier approach. RESULTS: Database query identified 19 patients who underwent 22 resections for suspected residual disease with therapeutic intent following immunotherapy between 2012 and 2016...
March 14, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29548582/definitive-chemoradiotherapy-versus-neoadjuvant-chemoradiotherapy-followed-by-surgery-for-stage-ii-to-iii-esophageal-squamous-cell-carcinoma
#14
Arianna Barbetta, Meier Hsu, Kay See Tan, Dessislava Stefanova, Koby Herman, Prasad S Adusumilli, Manjit S Bains, Matthew J Bott, James M Isbell, Yelena Y Janjigian, Geoffrey Y Ku, Bernard J Park, Abraham J Wu, David R Jones, Daniela Molena
OBJECTIVE: Definitive chemoradiotherapy (CRT) remains the most commonly used treatment for locally advanced esophageal squamous cell carcinoma (SCC), because of perceptions that esophagectomy offers an unclear survival advantage. We compare recurrence, overall survival (OS), and disease-free survival (DFS) in patients treated with definitive CRT or neoadjuvant CRT followed by surgery (trimodality). METHODS: This was a retrospective cohort study of patients with stage II and III SCC of the middle and distal esophagus in patients who completed CRT...
June 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29448738/synthesis-and-electroluminescent-properties-of-new-dibenzo-diazocine-derivatives
#15
Hyocheol Jung, Hayoon Lee, Jaemin Ryu, Donghee Shin, Miyeon Park, Kwang-Yol Kay, Jongwook Park
AK-1NA and AK-2NA based on dibenzo-diazocine and anthracene moieties were designed and synthesized. Normalized UV-visible spectra of AK-1NA and AK-2NA in film state showed maximum absorption wavelength of 394 and 393 nm. PL spectra of AK-1NA and AK-2NA showed maximum emission wavelength of 429 and 444 nm. At a current density of 10 mA/cm2, OLED devices of AK-1NA and AK-2NA exhibited luminance efficiency of 2.39 and 1.50 cd/A, power efficiency of 1.01 and 0.81 lm/W. Also, OLED devices of AK-1NA and AK-2NA devices exhibited CIE(x, y ) of (0...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448736/synthesis-and-electroluminescence-properties-of-new-type-multi-chromophore-emitting-materials-for-organic-light-emitting-diodes
#16
Seokwoo Kang, Hayoon Lee, Hyocheol Jung, Donghee Shin, Miyeon Park, Kwang-Yol Kay, Jongwook Park
New three emitting compounds, AK-1, AK-2 and AK-3 including diazocine moiety were synthesized through Suzuki-coupling reaction. Physical properties such as optical, electroluminescent properties were investigated. UV-visible spectrum of AK-1, AK-2 and AK-3 in film state showed maximum 392, 393 and 401 nm. PL spectrum of AK-1, AK-2 and AK-3 showed maximum emission wavelength of 472, 473 and 435 nm. Three compounds were used as EML in OLED device: ITO/2-TNATA (60 nm)/NPB (15 nm)/EML (35 nm)/Alq3 (20 nm)/LiF (1 nm)/Al (200 nm)...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29439692/automated-chart-review-utilizing-natural-language-processing-algorithm-for-asthma-predictive-index
#17
Harsheen Kaur, Sunghwan Sohn, Chung-Il Wi, Euijung Ryu, Miguel A Park, Kay Bachman, Hirohito Kita, Ivana Croghan, Jose A Castro-Rodriguez, Gretchen A Voge, Hongfang Liu, Young J Juhn
BACKGROUND: Thus far, no algorithms have been developed to automatically extract patients who meet Asthma Predictive Index (API) criteria from the Electronic health records (EHR) yet. Our objective is to develop and validate a natural language processing (NLP) algorithm to identify patients that meet API criteria. METHODS: This is a cross-sectional study nested in a birth cohort study in Olmsted County, MN. Asthma status ascertained by manual chart review based on API criteria served as gold standard...
February 13, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29438695/eradication-of-triple-negative-breast-cancer-cells-by-targeting-glycosylated-pd-l1
#18
Chia-Wei Li, Seung-Oe Lim, Ezra M Chung, Yong-Soo Kim, Andrew H Park, Jun Yao, Jong-Ho Cha, Weiya Xia, Li-Chuan Chan, Taewan Kim, Shih-Shin Chang, Heng-Huan Lee, Chao-Kai Chou, Yen-Liang Liu, Hsin-Chih Yeh, Evan P Perillo, Andrew K Dunn, Chu-Wei Kuo, Kay-Hooi Khoo, Jennifer L Hsu, Yun Wu, Jung-Mao Hsu, Hirohito Yamaguchi, Tzu-Hsuan Huang, Aysegul A Sahin, Gabriel N Hortobagyi, Stephen S Yoo, Mien-Chie Hung
Protein glycosylation provides proteomic diversity in regulating protein localization, stability, and activity; it remains largely unknown whether the sugar moiety contributes to immunosuppression. In the study of immune receptor glycosylation, we showed that EGF induces programmed death ligand 1 (PD-L1) and receptor programmed cell death protein 1 (PD-1) interaction, requiring β-1,3-N-acetylglucosaminyl transferase (B3GNT3) expression in triple-negative breast cancer. Downregulation of B3GNT3 enhances cytotoxic T cell-mediated anti-tumor immunity...
February 12, 2018: Cancer Cell
https://www.readbyqxmd.com/read/29438362/gene-and-pathway-level-analyses-of-germline-dna-repair-gene-variants-and-prostate-cancer-susceptibility-using-the-icogs-genotyping-array
#19
Edward J Saunders, Tokhir Dadaev, Daniel A Leongamornlert, Ali Amin Al Olama, Sara Benlloch, Graham G Giles, Fredrik Wiklund, Henrik Grönberg, Christopher A Haiman, Johanna Schleutker, Børge G Nordestgaard, Ruth C Travis, David Neal, Nora Pasayan, Kay-Tee Khaw, Janet L Stanford, William J Blot, Stephen N Thibodeau, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Jong Y Park, Radka Kaneva, Jyotsna Batra, Manuel R Teixeira, Hardev Pandha, Koveela Govindasami, Ken Muir, Douglas F Easton, Rosalind A Eeles, Zsofia Kote-Jarai
This corrects the article DOI: 10.1038/bjc.2016.50.
March 20, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29438173/fallopian-tube-mucosal-involvement-in-cervical-gastric-type-adenocarcinomas-report-of-a-series-with-discussion-of-the-distinction-from-synchronous-in-situ-tubal-lesions
#20
Simon Rajendran, Yaser Hussein, Kay J Park, W Glenn McCluggage
Cervical gastric-type adenocarcinomas are aggressive non-human papillomavirus-related carcinomas with a propensity for extracervical spread, including unusual sites such as the omentum, peritoneum, and ovary. We report 7 cases of cervical gastric-type adenocarcinoma with fallopian tube involvement predominantly in the form of mucosal colonization without underlying invasion. As far as we are aware, this has not been previously described and this report adds to the literature regarding metastatic neoplasms, which may exhibit tubal mucosal involvement and mimic an in situ lesion at this site...
February 12, 2018: American Journal of Surgical Pathology
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