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Teri longacre

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https://www.readbyqxmd.com/read/27863403/enumeration-and-targeted-analysis-of-kras-braf-and-pik3ca-mutations-in-ctcs-captured-by-a-label-free-platform-comparison-to-ctdna-and-tissue-in-metastatic-colorectal-cancer
#1
Evelyn Kidess-Sigal, Haiyan E Liu, Melanie M Triboulet, James Che, Vishnu C Ramani, Brendan C Visser, George A Poultsides, Teri A Longacre, Andre Marziali, Valentina Vysotskaia, Matthew Wiggin, Kyra Heirich, Violet Hanft, Ulrich Keilholz, Ingeborg Tinhofer, Jeffrey A Norton, Mark Lee, Elodie Sollier-Christen, Stefanie S Jeffrey
Treatment of advanced colorectal cancer (CRC) requires multimodal therapeutic approaches and need for monitoring tumor plasticity. Liquid biopsy biomarkers, including CTCs and ctDNA, hold promise for evaluating treatment response in real-time and guiding therapeutic modifications. From 15 patients with advanced CRC undergoing liver metastasectomy with curative intent, we collected 41 blood samples at different time points before and after surgery for CTC isolation and quantification using label-free Vortex technology...
November 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27575375/pancreatic-cancer-surgical-resection-margins-molecular-assessment-by-mass-spectrometry-imaging
#2
Livia S Eberlin, Katherine Margulis, Ivette Planell-Mendez, Richard N Zare, Robert Tibshirani, Teri A Longacre, Moe Jalali, Jeffrey A Norton, George A Poultsides
BACKGROUND: Surgical resection with microscopically negative margins remains the main curative option for pancreatic cancer; however, in practice intraoperative delineation of resection margins is challenging. Ambient mass spectrometry imaging has emerged as a powerful technique for chemical imaging and real-time diagnosis of tissue samples. We applied an approach combining desorption electrospray ionization mass spectrometry imaging (DESI-MSI) with the least absolute shrinkage and selection operator (Lasso) statistical method to diagnose pancreatic tissue sections and prospectively evaluate surgical resection margins from pancreatic cancer surgery...
August 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27487741/low-grade-serous-carcinoma-of-the-ovary-clinicopathologic-analysis-of-52-invasive-cases-and-identification-of-a-possible-noninvasive-intermediate-lesion
#3
Geunghwan Ahn, Ann K Folkins, Jesse K McKenney, Teri A Longacre
Low-grade serous carcinoma (LGSC) is an uncommon but distinct histologic subtype of ovarian carcinoma. Although the histologic features and natural history of LGSC have been described in the literature, there is no robust correlative study that has specifically addressed histologic features in correlation with clinical follow-up. To refine the criteria for invasion patterns of LGSC and determine additional clinically pertinent morphologic features of LGSC predisposing to a more aggressive clinical course, the clinicopathologic features of 52 LGSCs were evaluated and compared with those of a large series of serous borderline tumors (SBT), with and without invasive implants...
September 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27428735/classification-of-extraovarian-implants-in-patients-with-ovarian-serous-borderline-tumors-tumors-of-low-malignant-potential-based-on-clinical-outcome
#4
Jesse K McKenney, C Blake Gilks, Steve Kalloger, Teri A Longacre
The classification of extraovarian disease into invasive and noninvasive implants predicts patient outcome in patients with high-stage ovarian serous borderline tumors (tumors of low malignant potential). However, the morphologic criteria used to classify implants vary between studies. To date, there has been no large-scale study with follow-up data comparing the prognostic significance of competing criteria. Peritoneal and/or lymph node implants from 181 patients with high-stage serous borderline tumors were evaluated independently by 3 pathologists for the following 8 morphologic features: micropapillary architecture; glandular architecture; nests of epithelial cells with surrounding retraction artifact set in densely fibrotic stroma; low-power destructive tissue invasion; single eosinophilic epithelial cells within desmoplastic stroma; mitotic activity; nuclear pleomorphism; and nucleoli...
September 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27255163/pattern-classification-of-endocervical-adenocarcinoma-reproducibility-and-review-of-criteria
#5
Joanne K L Rutgers, Andres A Roma, Kay J Park, Richard J Zaino, Abbey Johnson, Isabel Alvarado, Dean Daya, Golnar Rasty, Teri A Longacre, Brigitte M Ronnett, Elvio G Silva
Previously, our international team proposed a three-tiered pattern classification (Pattern Classification) system for endocervical adenocarcinoma of the usual type that correlates with nodal disease and recurrence. Pattern Classification-A tumors have well-demarcated glands lacking destructive stromal invasion or lymphovascular invasion, Pattern Classification-B tumors show localized, limited destructive invasion arising from A-type glands, and Pattern Classification-C tumors have diffuse destructive stromal invasion, significant (filling a 4 × field) confluence, or solid architecture...
September 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27241104/lynch-syndrome-female-genital-tract-cancer-diagnosis-and-screening
#6
REVIEW
Anne M Mills, Teri A Longacre
Lynch syndrome is responsible for approximately 5% of endometrial cancers and 1% of ovarian cancers. The molecular basis for Lynch syndrome is a heritable functional deficiency in the DNA mismatch repair system, typically due to a germline mutation. This review discusses the rationales and relative merits of current Lynch syndrome screening tests for endometrial and ovarian cancers and provides pathologists with an informed algorithmic approach to Lynch syndrome testing in gynecologic cancers. Pitfalls in test interpretation and strategies to resolve discordant test results are presented...
June 2016: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/27035983/identification-of-tumorigenic-cells-and-therapeutic-targets-in-pancreatic-neuroendocrine-tumors
#7
Geoffrey Wayne Krampitz, Benson M George, Stephen B Willingham, Jens-Peter Volkmer, Kipp Weiskopf, Nadine Jahchan, Aaron M Newman, Debashis Sahoo, Allison J Zemek, Rebecca L Yanovsky, Julia K Nguyen, Peter J Schnorr, Pawel K Mazur, Julien Sage, Teri A Longacre, Brendan C Visser, George A Poultsides, Jeffrey A Norton, Irving L Weissman
Pancreatic neuroendocrine tumors (PanNETs) are a type of pancreatic cancer with limited therapeutic options. Consequently, most patients with advanced disease die from tumor progression. Current evidence indicates that a subset of cancer cells is responsible for tumor development, metastasis, and recurrence, and targeting these tumor-initiating cells is necessary to eradicate tumors. However, tumor-initiating cells and the biological processes that promote pathogenesis remain largely uncharacterized in PanNETs...
April 19, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/26872009/lynch-syndrome-screening-in-the-gynecologic-tract-current-state-of-the-art
#8
REVIEW
Anne M Mills, Teri A Longacre
Lynch syndrome underlies approximately 5% of endometrial cancers and ∼1% of ovarian cancers. Gynecologic malignancies are often the presenting cancer in these patients. Therefore, there is considerable benefit to identifying these patients and enrolling them and affected family members in surveillance programs for secondary malignancies. The molecular basis for Lynch syndrome is a defect in the DNA mismatch repair (MMR) system. Tumors can be screened for these defects using immunohistochemistry to identify loss of MMR proteins or by enlisting polymerase chain reaction to identify the microsatellite instability that attends dysfunctional MMR...
April 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/26856716/adenovirus-hepatic-abscess-a-novel-source-of-fever-of-unknown-origin-in-a-pediatric-liver-transplant-recipient
#9
Kelly Haas, Teri Longacre, Ricardo O Castillo
No abstract text is available yet for this article.
February 8, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/26838774/smooth-muscle-tumors-of-the-female-genital-tract
#10
REVIEW
Anne M Mills, Teri A Longacre
Smooth muscle tumors are the most common among mesenchymal tumors in the female genital tract. The vast majority of these neoplasms are clinically benign and easy to diagnose. In contrast, leiomyosarcomas are highly aggressive tumors that may pose considerable diagnostic problems when they display unusual (myxoid or epithelioid) morphology, ambiguous histologic features for malignancy, or an unusual anatomic distribution. Diagnostic criteria for these problematic tumors vary depending on the site and type of histologic differentiation, and are based on a combination of 3 major criteria: (1) moderate to severe cytologic atypia; (2) increased mitotic index; and (3) tumor cell necrosis...
December 2009: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/26837298/benign-and-low-grade-serous-epithelial-tumors-recent-developments-and-diagnostic-problems
#11
REVIEW
Teri A Longacre
This review focuses on recent advances in the area of low-grade ovarian serous neoplasia with emphasis on key diagnostic criteria, differential diagnosis, and disease classification based on current understanding of low-grade serous carcinogenesis. Despite considerable controversy surrounding serous tumors of low malignant potential (S-LMP) or borderline tumors, there have been great strides in our understanding of the serous group of borderline and malignant pelvic epithelial neoplasms in the past decade. Most S-LMP have a favorable prognosis, but recurrences and progression to carcinoma occur, sometimes following a protracted clinical course...
March 2011: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/26837292/atypical-endometrial-hyperplasia-and-well-differentiated-endometrioid-adenocarcinoma-of-the-uterine-corpus
#12
REVIEW
Anne M Mills, Teri A Longacre
The distinction between atypical endometrial hyperplasia and well differentiated adenocarcinoma of the endometrium is one of the more difficult differential diagnoses in gynecologic pathology. Different pathologists apply different histologic criteria, often with different individual thresholds for atypical endometrial hyperplasia and grade 1 adenocarcinoma. While some classifications are based on a series of molecular genetic alterations (which may or may not translate into biologically or clinically relevant risk lesions), almost all current diagnostic criteria use a series of histologic features - usually a combination of architecture and cytology - for diagnosing atypical hyperplasia and adenocarcinoma...
March 2011: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/26813747/mismatch-repair-protein-expression-in-clear-cell-carcinoma-of-the-ovary-incidence-and-morphologic-associations-in-109-cases
#13
MULTICENTER STUDY
Jennifer A Bennett, Vicente Morales-Oyarvide, Sharon Campbell, Teri A Longacre, Esther Oliva
Several morphologic features have been reported to be predictive of abnormal expression of mismatch repair (MMR) proteins in endometrial and colon carcinomas. Although it is known that abnormal MMR expression is increased in frequency in ovarian endometrioid and clear cell carcinomas, no such histologic correlation has been identified. We reviewed 109 unselected ovarian clear cell carcinomas for specific tumor characteristics (architecture, nuclear atypia, signet ring cells, stromal hyalinization, background precursor) and inflammatory response (peritumoral lymphocytes found along the leading edge of the tumor, intratumoral stromal inflammation found within the tumor, percentage of plasma cells in the intratumoral stromal inflammation, tumor-infiltrating lymphocytes) and performed immunohistochemistry for all 4 MMR proteins...
May 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/26469398/intraductal-papillary-mucinous-neoplasms-often-contain-epithelium-from-multiple-subtypes-and-or-are-unclassifiable
#14
REVIEW
Kurt B Schaberg, Michael A DiMaio, Teri A Longacre
Pancreatic intraductal papillary mucinous neoplasms (IPMNs) are subclassified into gastric, intestinal, pancreatobiliary, and oncocytic subtypes based on histologic features. The WHO classification scheme suggests use of immunohistochemical stains to help subtype IPMNs with ambiguous histology. Seventy-two pancreatic IPMN resections between 2008 and 2014 were retrospectively evaluated. Immunohistochemistry for CDX2, MUC2, and MUC5AC was performed on cases where the histologic subtype could not be determined on routine hematoxylin and eosin (H&E) sections...
January 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/26469323/utility-of-peripherin-versus-map-2-and-calretinin-in-the-evaluation-of-hirschsprung-disease
#15
Karen M Chisholm, Teri A Longacre
Hirschsprung disease (HD) is a congenital malformation resulting from the lack of migration of ganglion cells in the colon. The absence of ganglion cells in rectal suction biopsies aids in diagnosis, but evaluation of these small biopsies can be difficult. In this study, we compare the microtubule-associated protein-2 (MAP-2), calretinin, and peripherin immunohistochemical stains in 237 selected biopsies performed to rule out HD. By H&E stain, a total of 78 biopsies had ganglion cells, whereas 83 biopsies had no ganglion cells, and an additional 76 biopsies were equivocal for ganglion cells...
October 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/26426383/idelalisib-associated-enterocolitis-clinicopathologic-features-and-distinction-from-other-enterocolitides
#16
Christine Y Louie, Michael A DiMaio, Karen E Matsukuma, Steven E Coutre, Gerald J Berry, Teri A Longacre
Idelalisib is a highly specific small-molecule phosphoinositide-3-kinase δ inhibitor that was recently approved by the Food and Drug Administration for the treatment of chronic lymphocytic leukemia/small lymphocytic lymphoma and follicular lymphoma. The known side effects of idelalisib include severe diarrhea and colitis. Here we report the histologic findings in idelalisib-associated enterocolitis in 11 patients with chronic lymphocytic leukemia or follicular lymphoma receiving idelalisib over a 5-year period (2011 to 2015) at our institution...
December 2015: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/26157959/lanthanum-induced-gastrointestinal-histiocytosis
#17
Michael E Rothenberg, Hiwot Araya, Teri A Longacre, Pankaj J Pasricha
A patient with end-stage renal disease (ESRD) on hemodialysis presented with fever, anorexia, and nausea shortly after starting oral lanthanum carbonate for phosphate control. Gastric and duodenal biopsies demonstrated diffuse histiocytosis with intracellular aggregates of basophilic foreign material. Transmission electron microscopy, an underutilized diagnostic test, revealed the nature of the aggregates as heavy metal particles, consistent with lanthanum. Symptoms and histiocytosis improved after discontinuation of lanthanum...
April 2015: ACG Case Reports Journal
https://www.readbyqxmd.com/read/26127008/stereotactic-body-radiation-therapy-and-central-liver-toxicity-a-case-report
#18
Jenny L Shaffer, Evan C Osmundson, Brendan C Visser, Teri A Longacre, Albert C Koong, Daniel T Chang
No abstract text is available yet for this article.
September 2015: Practical Radiation Oncology
https://www.readbyqxmd.com/read/26026391/kit-signaling-promotes-growth-of-colon-xenograft-tumors-in-mice-and-is-up-regulated-in-a-subset-of-human-colon-cancers
#19
Evan C Chen, Taylor A Karl, Tomer Kalisky, Santosh K Gupta, Catherine A O'Brien, Teri A Longacre, Matt van de Rijn, Stephen R Quake, Michael F Clarke, Michael E Rothenberg
BACKGROUND & AIMS: Receptor tyrosine kinase (RTK) inhibitors have advanced colon cancer treatment. We investigated the role of the RTK KIT in development of human colon cancer. METHODS: An array of 137 patient-derived colon tumors and their associated xenografts were analyzed by immunohistochemistry to measure levels of KIT and its ligand KITLG. KIT and/or KITLG was stably knocked down by expression of small hairpin RNAs from lentiviral vectors in DLD1, HT29, LS174T, and COLO320 DM colon cancer cell lines, and in UM-COLON#8 and POP77 xenografts; cells transduced with only vector were used as controls...
September 2015: Gastroenterology
https://www.readbyqxmd.com/read/25824976/locally-advanced-intrahepatic-cholangiocarcinoma-complete-pathologic-response-to-neoadjuvant-chemotherapy-followed-by-left-hepatic-trisectionectomy-and-caudate-lobectomy
#20
Thuy B Tran, Chinmaya K Bal, Kurt Schaberg, Teri A Longacre, Bhupinder S Chatrath, George A Poultsides
No abstract text is available yet for this article.
November 2015: Digestive Diseases and Sciences
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