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Glenn mccluggage

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https://www.readbyqxmd.com/read/27866340/the-hereditary-nature-of-small-cell-carcinoma-of-the-ovary-hypercalcemic-type-two-new-familial-cases
#1
Leora Witkowski, Nancy Donini, Rebecca Byler-Dann, James A Knost, Steffen Albrecht, Andrew Berchuck, W Glenn McCluggage, Martin Hasselblatt, William D Foulkes
Small cell carcinoma of the ovary, hypercalcemic type, (SCCOHT) is the most common undifferentiated ovarian cancer in women aged under 40 years. SCCOHT is a monogenic disease, characterized by germline and somatic SMARCA4 mutations. Recent studies have stressed its morphological and clinical similarity to malignant rhabdoid tumours, which are usually caused by mutations in the related gene, SMARCB1. While familial tumours are rare, the incidence of germline mutations is relatively high, with up to 43% of SCCOHTs and 35% of rhabdoid tumours caused by germline mutations in SMARCA4 and SMARCB1, respectively...
November 19, 2016: Familial Cancer
https://www.readbyqxmd.com/read/27801763/unclassifiable-malignant-extraovarian-sex-cord-stromal-tumors-report-of-3-cases-and-review-of-extraovarian-sex-cord-stromal-tumors
#2
Rajeev Shah, W Glenn McCluggage
We report 3 cases of primary extraovarian unclassifiable malignant sex cord-stromal tumors. In all cases, the tumors involved the pelvis, peritoneum, and/or omentum and the morphologic features were essentially those of a poorly differentiated malignant neoplasm. A diagnosis of sex cord-stromal tumor was made on the basis of expression of several markers of ovarian sex cord-stromal tumors and exclusion of other neoplasms. In 1 case, an elevated serum testosterone was present at tumor progression. In reporting these cases, we draw attention to the problems in establishing a diagnosis that can be attributed to the extreme rarity of sex cord-stromal tumors in an extraovarian location and the rarity of unclassifiable malignant sex cord-stromal tumors in general, resulting in pathologists not considering this diagnosis...
October 31, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27801755/the-fallopian-tube-origin-and-primary-site-assignment-in-extrauterine-high-grade-serous-carcinoma-findings-of-a-survey-of-pathologists-and-clinicians
#3
W Glenn McCluggage, Lynn Hirschowitz, C Blake Gilks, Nafisa Wilkinson, Naveena Singh
Accumulating recent evidence suggests that the majority of extrauterine high-grade serous carcinomas (HGSCs) do not arise from the ovary as historically accepted but from the distal, fimbrial end of the fallopian tube from a precursor known as serous tubal intraepithelial carcinoma. There has been variable acceptance of this evidence among pathologists and clinicians dealing with "ovarian" cancer and this has resulted in wide variation in the assignment of primary site between different institutions when HGSC involves >1 anatomic site...
October 31, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27792064/seborrheic-keratosis-like-lesions-of-the-cervix-and-vagina-report-of-a-new-entity-possibly-related-to-low-risk-human-papillomavirus-infection
#4
Karen L Talia, W Glenn McCluggage
We report a series of 7 unusual and morphologically distinct cervical or upper vaginal lesions in women aged 41 to 70 years. The lesions involved the cervix in 3 cases, the upper vagina in 2, the cervix and vagina in 1, and in 1 case the site of origin could not be determined. The lesions had a consistent morphologic appearance with a surface "plaque-like" or "stuck-on" configuration apparent in those cases where surrounding normal tissues were present. Broad coalescing solid sheets and interconnecting trabeculae of cytologically bland cells with a rather "basaloid" appearance emanated from the surface and there were scattered squamous eddies...
October 27, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27787595/reproducibility-of-measurement-of-myometrial-invasion-in-endometrial-carcinoma
#5
Louis J M van der Putten, Koen van de Vijver, Carla Bartosch, Ben Davidson, Sonia Gatius, Xavier Matias-Guiu, W Glenn McCluggage, Gemma Toledo, Anneke A M van der Wurff, Johanna M A Pijnenborg, Leon F A G Massuger, Johan Bulten
Myometrial invasion (MI) as a percentage (%MI), categorized into <50 or ≥50 %, is an important predictor of prognosis in endometrial carcinoma. Recent studies suggest that tumor-free distance (TFD) to serosa and the absolute depth of invasion (DOI) might be stronger predictors of prognosis. Although reproducibility is important in clinical practice for patient prognostication and treatment, reproducibility of these methods for the measurement of MI is largely unknown. One or two slides from 50 patients with FIGO stage I endometrioid endometrial carcinoma were viewed by seven gynecological pathologists, who were requested to measure %MI, TFD, and DOI...
October 27, 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27776011/uterine-serous-carcinomas-frequently-metastasize-to-the-fallopian-tube-and-can-mimic-serous-tubal-intraepithelial-carcinoma
#6
Friedrich Kommoss, Asma Faruqi, C Blake Gilks, Sarah Lamshang Leen, Naveena Singh, Nafisa Wilkinson, W Glenn McCluggage
We investigated the frequency, histopathologic, and immunohistochemical characteristics of tubal involvement in uterine serous carcinoma (USC) and aimed to clarify the relationship between "serous tubal intraepithelial carcinoma (STIC)" and USC in these cases. Cases of USC with complete tubal examination were prospectively collected and reviewed for the presence of tubal involvement. Immunohistochemical analysis for p53 and WT1 was performed on the endometrial and tubal tumor in cases with tubal involvement...
October 21, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27656868/loss-of-expression-of-smarca4-brg1-smarca2-brm-and-smarcb1-ini1-in-undifferentiated-carcinoma-of-the-endometrium-is-not-uncommon-and-is-not-always-associated-with-rhabdoid-morphology
#7
Preetha Ramalingam, Sabrina Croce, W Glenn McCluggage
AIM: Abnormalities of SMARCB1 (INI1), which encodes a member of the SWI/SNF pathway, are found in neoplasms with rhabdoid morphology, such as malignant rhabdoid tumour of the kidney and atypical teratoid/rhabdoid tumour of the central nervous system. SMARCA4 (BRG1), which encodes another member of the SWI/SNF pathway, and which is mutated in almost all small-cell carcinomas of the ovary, hypercalcaemic type, has been investigated in endometrial carcinomas, and mutations with resultant loss of immunohistochemical staining have been demonstrated in some endometrial undifferentiated carcinomas/dedifferentiated carcinomas...
September 22, 2016: Histopathology
https://www.readbyqxmd.com/read/27504996/recently-characterized-molecular-events-in-uncommon-gynaecological-neoplasms-and-their-clinical-importance
#8
Leora Witkowski, W Glenn McCluggage, William D Foulkes
The introduction of new sequencing technologies has resulted in the discovery of commonly mutated genes in uncommon cancers, including non-epithelial ovarian neoplasms and other rare gynaecological tumours, such as cervical embryonal rhabdomyosarcoma. In some of these neoplasms, mutations in certain genes are both frequent and specific enough for the genomic mutations and sometimes their associated protein loss or overexpression to be used as an aid to diagnosis. In this review, we contrast previous gene identification methods with newer ones, and discuss how the new sequencing technologies (collectively referred to as 'next-generation sequencing') have permitted the identification of specific molecular events that characterize several rare gynaecological neoplasms...
August 9, 2016: Histopathology
https://www.readbyqxmd.com/read/27362902/the-chemotherapy-response-score-crs-interobserver-reproducibility-in-a-simple-and-prognostically-relevant-system-for-reporting-the-histologic-response-to-neoadjuvant-chemotherapy-in-tuboovarian-high-grade-serous-carcinoma
#9
Ian Said, Steffen Böhm, Joanne Beasley, Peter Ellery, Asma Z Faruqi, Raji Ganesan, Lynn Hirshowitz, Sharanpal Jeetle, Sarah Lam Shang Leen, W Glenn McCluggage, Jacqueline McDermott, Reena Merard, Thomas O Millner, Giorgia Trevisan, Jo Vella, C Blake Gilks, Naveena Singh
A 3-tier histopathologic scoring system, the chemotherapy response score (CRS), was previously devised for reporting the histologic response to neoadjuvant chemotherapy in interval debulking surgery specimens of stage IIIc/IV tuboovarian high-grade serous carcinoma. This has been shown to predict the outcome and offer additional information to other methods of assessing the treatment response. In the present study, the reproducibility of this scoring system was assessed by determining the interobserver agreement among reporting pathologists...
June 29, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27353327/prior-knowledge-transfer-across-transcriptional-data-sets-and-technologies-using-compositional-statistics-yields-new-mislabelled-ovarian-cell-line
#10
Jaine K Blayney, Timothy Davison, Nuala McCabe, Steven Walker, Karen Keating, Thomas Delaney, Caroline Greenan, Alistair R Williams, W Glenn McCluggage, Amanda Capes-Davis, D Paul Harkin, Charlie Gourley, Richard D Kennedy
Here, we describe gene expression compositional assignment (GECA), a powerful, yet simple method based on compositional statistics that can validate the transfer of prior knowledge, such as gene lists, into independent data sets, platforms and technologies. Transcriptional profiling has been used to derive gene lists that stratify patients into prognostic molecular subgroups and assess biomarker performance in the pre-clinical setting. Archived public data sets are an invaluable resource for subsequent in silico validation, though their use can lead to data integration issues...
September 30, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27334714/yolk-sac-tumours-of-the-female-genital-tract-in-older-adults-derive-commonly-from-somatic-epithelial-neoplasms-somatically-derived-yolk-sac-tumours
#11
Tamara McNamee, Stephen Damato, W Glenn McCluggage
AIMS: To report 18 yolk sac tumours (YSTs) of the female genital tract (17 ovary, one uterus) in patients aged 40 years or over, most arising from a somatic epithelial neoplasm. METHODS AND RESULTS: Six patients had pure YST, two were associated with immature teratoma (one with an endometrioid adenocarcinoma) and in 11 there was an epithelial neoplasm comprising high-grade serous carcinoma (HGSC) (n = 5), clear cell carcinoma (n = 1), borderline clear cell adenofibroma (n = 1), endometrioid adenocarcinoma (n = 2), serous tubal intra-epithelial carcinoma (n = 1) and large-cell neuroendocrine carcinoma (n = 1)...
November 2016: Histopathology
https://www.readbyqxmd.com/read/27241113/gynecologic-pathology
#12
EDITORIAL
Blaise A Clarke, W Glenn McCluggage
No abstract text is available yet for this article.
June 2016: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/27241105/small-cell-carcinoma-of-the-ovary-of-hypercalcemic-type-malignant-rhabdoid-tumor-of-the-ovary-a-review-with-recent-developments-on-pathogenesis
#13
REVIEW
Leora Witkowski, Catherine Goudie, William D Foulkes, W Glenn McCluggage
Small-cell carcinoma of the ovary of hypercalcemic type (SCCOHT) is a highly malignant and aggressive tumor and is the most common undifferentiated ovarian malignancy to occur in women younger than 40. SCCOHT is characterized by deleterious germline or somatic mutations in SMARCA4. Given the striking morphologic and molecular similarities between SCCOHT and atypical teratoid/malignant rhabdoid tumor, we propose this should be reflected in a nomenclature change and that SCCOHT be renamed malignant rhabdoid tumor of the ovary...
June 2016: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/27171540/an-unusual-case-of-ywhae-nutm2a-b-endometrial-stromal-sarcoma-with-confinement-to-the-endometrium-and-lack-of-high-grade-morphology
#14
Ayoma D Attygalle, Katherine Vroobel, Dorte Wren, Desmond P J Barton, Stephen J Hazell, Paola Dal Cin, Konrad Koelble, W Glenn McCluggage
Endometrial stromal sarcoma (ESS) characterized by YWHAE-NUTM2A/B genetic fusion is a recently recognized entity that is classified as a high-grade (HG) ESS in the 2014 World Health Organization Classification. These are myoinvasive neoplasms and typically contain a monomorphous HG round-cell cyclinD1-positive component with or without an accompanying low-grade (LG) component that is only focally positive/negative for cyclinD1. We report a case of YWHAE-NUTM2A/B ESS in a 46-yr-old woman that showed a number of unusual histologic features, including being entirely confined to the endometrium with no myoinvasion or lymphovascular space invasion...
May 11, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27167675/endocervical-polyp-with-florid-epidermal-metaplasia-report-of-a-previously-undescribed-phenomenon
#15
Seema Angra, W Glenn McCluggage
Endocervical polyps are common benign lesions which rarely result in diagnostic problems, although a variety of alterations occasionally complicate histologic interpretation. We report an unusual, and not previously described, finding of florid "epidermal" metaplasia with keratinization and extensive formation of skin appendages structures (sebaceous and sweat glands and hair follicles) within an endocervical polyp. The features closely resembled an epidermal inclusion cyst. We speculate on the possible pathogenesis of this rare phenomenon and review unusual findings in endocervical polyps...
September 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27149006/mitotically-active-sclerosing-stromal-tumor-of-the-ovary-report-of-a-case-series-with-parallels-to-mitotically-active-cellular-fibroma
#16
Emily A Goebel, W Glenn McCluggage, Joanna C Walsh
Sclerosing stromal tumor of the ovary is a rare neoplasm that typically occurs in the second and third decades of life. To date, all reported cases have behaved in a benign manner. In their usual form, these neoplasms exhibit scant, if any, mitotic activity. Herein, we report a case series of 6 sclerosing stromal tumors with increased mitotic activity (between 7 and 12 mitoses per 10 high-power fields in the most mitotically active areas). Follow-up is available in 4 of 6 cases (ranging from 3 wk to 68 mo) and 1 tumor recurred within the pelvis...
May 4, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27100627/loss-of-smarca4-brg1-protein-expression-by-immunohistochemistry-in-small-cell-carcinoma-of-the-ovary-hypercalcemic-type-distinguishes-these-tumors-from-their-mimics
#17
Blaise A Clarke, Leora Witkowski, Tuyet Nhung Ton Nu, Patricia A Shaw, C Blake Gilks, David Huntsman, Tony Karnezis, Neil Sebire, Janez Lamovec, Lawrence M Roth, Colin Jr Stewart, Martin Hasselblatt, William D Foulkes, W Glenn McCluggage
AIMS: Molecular interrogation of small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) has revealed that it is a monogenetic tumor characterized by alteration of SMARCA4 (BRG1), a member of the Switch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex. A large majority of cases show loss of expression of the corresponding SMARCA4/BRG1 protein. Furthermore, three cases of SCCOHT with retained SMARCA4 protein expression demonstrated loss of expression of SMARCB1/ INI1...
April 21, 2016: Histopathology
https://www.readbyqxmd.com/read/27097978/differential-expression-of-e-cadherin-and-catenins-in-ovarian-sex-cord-stromal-tumours
#18
Stavroula Stavrinou, Ashleigh Clark, Julie Irving, Cheng-Han Lee, Esther Oliva, Robert Young, Ruethairat Sriraksa, Nesreen Magdy, Susan Van Noorden, W Glenn McCluggage, Mona El-Bahrawy
AIMS: Sex cord stromal tumours (SCSTs) of the ovary encompass several histological tumour subtypes that are defined by characteristic histological features. Some can show morphological overlap with other subtypes of SCSTs, as well as with non-SCSTs. The E-cadherin/catenin complex constitutes the adherens junction, which is well developed in epithelial tissue, but the constituent molecules are also expressed in several non-epithelial tumours. The aim of this study was to determine whether the expression patterns of E-cadherin and catenins in ovarian SCSTs can be of diagnostic utility...
August 2016: Histopathology
https://www.readbyqxmd.com/read/27079213/rare-non-epithelial-ovarian-neoplasms-pathology-genetics-and-treatment
#19
REVIEW
William D Foulkes, Martin Gore, W Glenn McCluggage
Rare non-epithelial ovarian neoplasms have posed management challenges for many years. Their rarity means that most specialist practitioners will see one such case every several years, and most generalists may never see a case. The first step in management is to establish the correct diagnosis and this may necessitate specialist pathology review. Here, we review recent developments in the pathology, genetics and treatment of small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) and sex cord-stromal tumours...
July 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/26977579/adopting-a-uniform-approach-to-site-assignment-in-tubo-ovarian-high-grade-serous-carcinoma-the-time-has-come
#20
Naveena Singh, C Blake Gilks, Lynn Hirshowitz, Nafisa Wilkinson, W Glenn McCluggage
There is currently sufficient evidence that nonuterine high-grade serous carcinoma (HGSC) originates in the fallopian tube in the majority of cases, but this is not uniformly reflected in our diagnostic terminology. This is because there remains wide variation in awareness and acceptance of this evidence, which conflicts with traditional views on origin. Accurate disease classification is fundamental to routine clinical practice and research, particularly at a time when exciting new approaches to therapy, early detection, and prevention are appearing on the horizon...
May 2016: International Journal of Gynecological Pathology
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