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Glenn mccluggage

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https://www.readbyqxmd.com/read/28622684/the-association-between-mad2-and-prognosis-in-cancer-a%C3%A2-systematic-review-and-meta-analyses
#1
Tara Byrne, Helen G Coleman, Janine A Cooper, W Glenn McCluggage, Amanda McCann, Fiona Furlong
This systematic review and meta-analyses investigates the expression of the cell checkpoint regulator, mitotic arrest deficiency protein 2 (MAD2) in cancerous tissue and examines whether an association exists between MAD2 levels and cancer survival and recurrence. Studies investigating MAD2 expression in cancer tissue utilising immunohistochemistry (IHC) were identified by systematic literature searches of Medline, Embase and Web of Science databases by October 2015. Random effects meta-analyses were performed to generate pooled hazard ratios (HRs) with 95% confidence intervals (CIs) of overall and progression-free survival according to MAD2 expression...
June 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28582340/a-report-of-ovarian-sertoli-leydig-cell-tumors-with-heterologous-intestinal-type-glands-and-alpha-fetoprotein-elevation-and-review-of-the-literature
#2
Maysa Al-Hussaini, Yazan Al-Othman, Eman Hijazi, W Glenn McCluggage
Ovarian Sertoli-Leydig cell tumors (SLCTs) are uncommon neoplasms that are occasionally associated with an elevated level of serum alpha fetoprotein (AFP), a marker of germ cell neoplasms, particularly yolk sac tumor (YST). We report 7 cases of ovarian SLCT (3 moderately differentiated, 2 poorly differentiated, 2 retiform) with heterologous intestinal-type glands, 6 of which were associated with elevated serum AFP. The intestinal-type mucinous glands were immunoreactive for SALL4 (4 cases), AFP (4 cases), glypican 3 (1 case), CDX2 (6 cases), and villin (7 cases), markers that are commonly expressed in YSTs, although the latter 2 markers would be expected to be positive in intestinal-type glands...
June 2, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28490045/uterine-inflammatory-myofibroblastic-tumors-frequently-harbor-alk-fusions-with-igfbp5-and-thbs1
#3
Josh D Haimes, Colin J R Stewart, Brian A Kudlow, Brady P Culver, Bo Meng, Eleanor Koay, Ann Whitehouse, Nichola Cope, Jen-Chieh Lee, Tony Ng, W Glenn McCluggage, Cheng-Han Lee
Inflammatory myofibroblastic tumor (IMT) can occur in a number of anatomic sites, including the uterus. Like its soft tissue counterpart, uterine IMT frequently expresses ALK and harbors ALK genetic rearrangements. The aim of this study is to fully characterize the genetic fusions that occur in uterine IMT. We studied 11 uterine IMTs with typical histology and 8 uterine myxoid smooth muscle tumors (5 leiomyomas, 1 smooth muscle tumor of uncertain malignant potential, and 2 leiomyosarcomas) in which the differential of IMT was considered, using a RNA-sequencing-based fusion assay to detect genetic fusions involving ALK, ROS1, RET, NTRK1/3, and other genes...
June 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28477361/high-grade-serous-carcinoma-hgsc-of-tubo-ovarian-origin-recent-developments
#4
REVIEW
Naveena Singh, W Glenn McCluggage, C Blake Gilks
Extra-uterine high-grade serous carcinoma (HGSC) accounts for most of the morbidity and mortality associated with ovarian carcinoma, and is one of the leading causes of cancer death in women. Until recently our understanding of HGSC was very limited, compared to other common cancers, and it has only been in the last 15 years that we have learned how to accurately diagnose this ovarian carcinoma histotype. Since then, however, there has been rapid progress, with identification of a precursor lesion in the fallopian tube, development of prevention strategies for both those with inherited susceptibility (Hereditary Breast and Ovarian Cancer Syndrome) and without the syndrome, and elucidation of the molecular events important in oncogenesis...
May 6, 2017: Histopathology
https://www.readbyqxmd.com/read/28463909/fibroadenoma-like-lesion-of-the-vagina-a-description-of-2-cases-of-a-previously-unreported-entity
#5
Michelle Moore, Michael McKenna, Srinivas Mandavilli, W Glenn McCluggage
We report 2 cases of a previously undescribed vaginal lesion, which we term "fibroadenoma-like lesion of the vagina" because of the close morphologic resemblance to breast fibroadenoma. Both lesions arose in the upper vagina and exhibited a biphasic appearance with benign epithelial and stromal elements. The glandular epithelium comprised a double layer of luminal and basal cells with focal squamous differentiation in 1 case. The stromal component was fibroblastic and morphologically bland for the most part, although occasional atypical symplastic-like cells were present in 1 case...
April 29, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28418164/molecular-subtyping-of-mammary-like-adenocarcinoma-of-the-vulva-shows-molecular-similarity-to-breast-carcinomas
#6
Basile Tessier-Cloutier, Karama Asleh-Aburaya, Varsha Shah, W Glenn McCluggage, Anna Tinker, C Blake Gilks
AIMS: Mammary-like adenocarcinoma (MLA) of the vulva is thought to be derived from vulvar mammary-like glands. We characterized a series of MLA using an immunohistochemical algorithm that identifies the major molecular subtypes of breast cancer. METHODS AND RESULTS: Seven cases of vulval MLA were stained for ER, PR, HER2, Ki-67, EGFR, CK5, nestin and INPP4b. 17 cases of vulval extramammary Paget disease (EMPD), 7 with invasion, were studied for comparison. The median age of patients with MLA was 72 years...
April 18, 2017: Histopathology
https://www.readbyqxmd.com/read/28394803/hpv-negative-gastric-type-adenocarcinoma-in-situ-of-the-cervix-a-spectrum-of-rare-lesions-exhibiting-gastric-and-intestinal-differentiation
#7
Karen L Talia, Colin J R Stewart, Brooke E Howitt, Marisa R Nucci, W Glenn McCluggage
In recent years, a number of benign and malignant cervical glandular lesions exhibiting gastric differentiation have been described but premalignant gastric-type lesions have not been well characterized. We report a series of 9 cases of a rare form of cervical adenocarcinoma in situ (AIS) distinguished by gastric and sometimes intestinal differentiation and lack of association with human papillomavirus (HPV) infection. The lesions occurred in women aged 25 to 73 years (mean age 51 y). All cases were located at (or just proximal to) the cervical transformation zone and there was extension to the lower uterine segment in 3 cases, 2 of which also involved the endometrium...
April 7, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28221217/interobserver-reproducibility-among-gynecologic-pathologists-in-diagnosing-heterologous-osteosarcomatous-component-in-gynecologic-tract-carcinosarcomas
#8
Ankur R Sangoi, Malti Kshirsagar, Andres A Roma, Andrew E Horvai, Mamatha Chivukula, Lora H Ellenson, Oluwole Fadare, Ann K Folkins, Karuna Garg, Krisztina Hanley, Teri A Longacre, Jacqueline Haas, W Glenn McCluggage, Jesse K McKenney, Marisa R Nucci, Esther Oliva, Kay J Park, Vinita Parkash, Charles M Quick, Joseph T Rabban, Joanne K L Rutgers, Robert Soslow, Russell Vang, Anna Yemelyanova, Charles Zaloudek, Andrew H Beck
Distinguishing hyalinized stroma from osteoid production by a heterologous osteosarcomatous component can be challenging in gynecologic tract carcinosarcomas. As heterologous components in a carcinosarcoma may have prognostic and therapeutic implications, it is important that these are recognized. This study examines interobserver reproducibility among gynecologic pathologists in the diagnosis of osteosarcomatous components, and its correlation with expression of the novel antibody SATB2 (marker of osteoblastic differentiation) in these osteosarcomatous foci...
July 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28181955/minutes-of-the-business-meeting-of-the-international-society-of-gynecological-pathologists-isgyp-seattle-13th-march-2016
#9
Esther Oliva, W Glenn McCluggage
No abstract text is available yet for this article.
March 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28130795/clinical-morphological-and-immunohistochemical-evidence-that-small-cell-carcinoma-of-the-ovary-of-hypercalcaemic-type-sccoht-may-be-a-primitive-germ-cell-neoplasm
#10
W Glenn McCluggage, Leora Witkowski, Blaise A Clarke, William D Foulkes
AIMS: The histogenesis and cell lineage of small-cell carcinoma of the ovary of hypercalcaemic type (SCCOHT) is unknown. We aim to provide evidence that this may be a primitive germ-cell neoplasm arising from a teratoma. METHODS AND RESULTS: Following the identification of two cases of SCCOHT associated with germ-cell tumours (one dermoid cyst, one immature teratoma with a focus of yolk sac tumour), we undertook a literature review to look for any prior reports of SCCOHT in association with other neoplasms or elements...
January 28, 2017: Histopathology
https://www.readbyqxmd.com/read/28125452/morphologic-reproducibility-genotyping-and-immunohistochemical-profiling-do-not-support-a-category-of-seromucinous-carcinoma-of-the-ovary
#11
COMPARATIVE STUDY
Peter F Rambau, John B McIntyre, Jennifer Taylor, Sandra Lee, Travis Ogilvie, Anna Sienko, Don Morris, Máire A Duggan, W Glenn McCluggage, Martin Köbel
The 2014 World Health Organization Classification of Tumors of Female Reproductive Organs endorsed the new category of seromucinous carcinoma, a neoplasm that exhibits morphologic and immunophenotypic overlap with other histotypes of ovarian carcinoma. The goal of this study was to determine whether seromucinous carcinoma was a distinct histotype by assessing its diagnostic reproducibility and comparing its molecular composition to the 5 major histotypes of ovarian carcinoma. Thirty-two tumors diagnosed as seromucinous carcinomas from 2 centers were studied...
May 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28118159/clear-cell-carcinoma-of-the-cervix-with-choriocarcinomatous-differentiation-report-of-an-extremely-rare-phenomenon-associated-with-mismatch-repair-protein-abnormality
#12
Pinias Mukonoweshuro, W Glenn McCluggage
The presence of trophoblastic differentiation or nongestational choriocarcinoma in a carcinoma is rare but has been described in various organs, including in the female genital tract. We report a cervical clear cell carcinoma admixed with a component of choriocarcinoma in a 52-year-old woman, only the second report of this combination in the literature. Immunohistochemically, the tumor exhibited isolated loss of staining with the mismatch repair protein MSH6. We review the literature on trophoblastic differentiation in cervical carcinoma...
July 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27866340/the-hereditary-nature-of-small-cell-carcinoma-of-the-ovary-hypercalcemic-type-two-new-familial-cases
#13
Leora Witkowski, Nancy Donini, Rebecca Byler-Dann, James A Knost, Steffen Albrecht, Andrew Berchuck, W Glenn McCluggage, Martin Hasselblatt, William D Foulkes
Small cell carcinoma of the ovary, hypercalcemic type, (SCCOHT) is the most common undifferentiated ovarian cancer in women aged under 40 years. SCCOHT is a monogenic disease, characterized by germline and somatic SMARCA4 mutations. Recent studies have stressed its morphological and clinical similarity to malignant rhabdoid tumours, which are usually caused by mutations in the related gene, SMARCB1. While familial tumours are rare, the incidence of germline mutations is relatively high, with up to 43% of SCCOHTs and 35% of rhabdoid tumours caused by germline mutations in SMARCA4 and SMARCB1, respectively...
November 19, 2016: Familial Cancer
https://www.readbyqxmd.com/read/27801763/unclassifiable-malignant-extraovarian-sex-cord-stromal-tumors-report-of-3-cases-and-review-of-extraovarian-sex-cord-stromal-tumors
#14
Rajeev Shah, W Glenn McCluggage
We report 3 cases of primary extraovarian unclassifiable malignant sex cord-stromal tumors. In all cases, the tumors involved the pelvis, peritoneum, and/or omentum and the morphologic features were essentially those of a poorly differentiated malignant neoplasm. A diagnosis of sex cord-stromal tumor was made on the basis of expression of several markers of ovarian sex cord-stromal tumors and exclusion of other neoplasms. In 1 case, an elevated serum testosterone was present at tumor progression. In reporting these cases, we draw attention to the problems in establishing a diagnosis that can be attributed to the extreme rarity of sex cord-stromal tumors in an extraovarian location and the rarity of unclassifiable malignant sex cord-stromal tumors in general, resulting in pathologists not considering this diagnosis...
October 31, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27801755/the-fallopian-tube-origin-and-primary-site-assignment-in-extrauterine-high-grade-serous-carcinoma-findings-of-a-survey-of-pathologists-and-clinicians
#15
W Glenn McCluggage, Lynn Hirschowitz, C Blake Gilks, Nafisa Wilkinson, Naveena Singh
Accumulating recent evidence suggests that the majority of extrauterine high-grade serous carcinomas (HGSCs) do not arise from the ovary as historically accepted but from the distal, fimbrial end of the fallopian tube from a precursor known as serous tubal intraepithelial carcinoma. There has been variable acceptance of this evidence among pathologists and clinicians dealing with "ovarian" cancer and this has resulted in wide variation in the assignment of primary site between different institutions when HGSC involves >1 anatomic site...
October 31, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27792064/seborrheic-keratosis-like-lesions-of-the-cervix-and-vagina-report-of-a-new-entity-possibly-related-to-low-risk-human-papillomavirus-infection
#16
Karen L Talia, W Glenn McCluggage
We report a series of 7 unusual and morphologically distinct cervical or upper vaginal lesions in women aged 41 to 70 years. The lesions involved the cervix in 3 cases, the upper vagina in 2, the cervix and vagina in 1, and in 1 case the site of origin could not be determined. The lesions had a consistent morphologic appearance with a surface "plaque-like" or "stuck-on" configuration apparent in those cases where surrounding normal tissues were present. Broad coalescing solid sheets and interconnecting trabeculae of cytologically bland cells with a rather "basaloid" appearance emanated from the surface and there were scattered squamous eddies...
April 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27787595/reproducibility-of-measurement-of-myometrial-invasion-in-endometrial-carcinoma
#17
Louis J M van der Putten, Koen van de Vijver, Carla Bartosch, Ben Davidson, Sonia Gatius, Xavier Matias-Guiu, W Glenn McCluggage, Gemma Toledo, Anneke A M van der Wurff, Johanna M A Pijnenborg, Leon F A G Massuger, Johan Bulten
Myometrial invasion (MI) as a percentage (%MI), categorized into <50 or ≥50 %, is an important predictor of prognosis in endometrial carcinoma. Recent studies suggest that tumor-free distance (TFD) to serosa and the absolute depth of invasion (DOI) might be stronger predictors of prognosis. Although reproducibility is important in clinical practice for patient prognostication and treatment, reproducibility of these methods for the measurement of MI is largely unknown. One or two slides from 50 patients with FIGO stage I endometrioid endometrial carcinoma were viewed by seven gynecological pathologists, who were requested to measure %MI, TFD, and DOI...
January 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27776011/uterine-serous-carcinomas-frequently-metastasize-to-the-fallopian-tube-and-can-mimic-serous-tubal-intraepithelial-carcinoma
#18
Friedrich Kommoss, Asma Faruqi, C Blake Gilks, Sarah Lamshang Leen, Naveena Singh, Nafisa Wilkinson, W Glenn McCluggage
We investigated the frequency, histopathologic, and immunohistochemical characteristics of tubal involvement in uterine serous carcinoma (USC) and aimed to clarify the relationship between "serous tubal intraepithelial carcinoma (STIC)" and USC in these cases. Cases of USC with complete tubal examination were prospectively collected and reviewed for the presence of tubal involvement. Immunohistochemical analysis for p53 and WT1 was performed on the endometrial and tubal tumor in cases with tubal involvement...
February 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27656868/loss-of-expression-of-smarca4-brg1-smarca2-brm-and-smarcb1-ini1-in-undifferentiated-carcinoma-of-the-endometrium-is-not-uncommon-and-is-not-always-associated-with-rhabdoid-morphology
#19
Preetha Ramalingam, Sabrina Croce, W Glenn McCluggage
AIM: Abnormalities of SMARCB1 (INI1), which encodes a member of the SWI/SNF pathway, are found in neoplasms with rhabdoid morphology, such as malignant rhabdoid tumour of the kidney and atypical teratoid/rhabdoid tumour of the central nervous system. SMARCA4 (BRG1), which encodes another member of the SWI/SNF pathway, and which is mutated in almost all small-cell carcinomas of the ovary, hypercalcaemic type, has been investigated in endometrial carcinomas, and mutations with resultant loss of immunohistochemical staining have been demonstrated in some endometrial undifferentiated carcinomas/dedifferentiated carcinomas...
February 2017: Histopathology
https://www.readbyqxmd.com/read/27504996/recently-characterized-molecular-events-in-uncommon-gynaecological-neoplasms-and-their-clinical-importance
#20
REVIEW
Leora Witkowski, W Glenn McCluggage, William D Foulkes
The introduction of new sequencing technologies has resulted in the discovery of commonly mutated genes in uncommon cancers, including non-epithelial ovarian neoplasms and other rare gynaecological tumours, such as cervical embryonal rhabdomyosarcoma. In some of these neoplasms, mutations in certain genes are both frequent and specific enough for the genomic mutations and sometimes their associated protein loss or overexpression to be used as an aid to diagnosis. In this review, we contrast previous gene identification methods with newer ones, and discuss how the new sequencing technologies (collectively referred to as 'next-generation sequencing') have permitted the identification of specific molecular events that characterize several rare gynaecological neoplasms...
December 2016: Histopathology
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