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JOURNAL ARTICLE
Esther García-Díez, María Elvira López-Oliva, Francisco Perez-Vizcaino, Jara Pérez-Jiménez, Sonia Ramos, María Ángeles Martín
We have recently developed a cocoa-carob blend (CCB) rich in polyphenols with antidiabetic properties. In this study, we investigated whether its benefits could be related to gut health and gut microbiota (GM) composition and the likely phenolic metabolites involved. Zucker diabetic fatty rats were fed on a standard or a CCB-rich diet for 12 weeks. Intestinal barrier structure and oxidative and inflammatory biomarkers were analyzed in colonic samples. GM composition and phenolic metabolites were evaluated from feces...
July 29, 2023: Antioxidants (Basel, Switzerland)
#22
JOURNAL ARTICLE
Baris Boyraz, Arnaud da Cruz Paula, Kelly A Deveraux, Ivy Tran, Edaise M da Silva, Robert H Young, Matija Snuderl, Britta Weigelt, Esther Oliva
Endometrial/endometrioid stromal tumors are rare and morphologically heterogenous, and their diagnosis may be challenging. We identified 3 endometrial/endometrioid stromal tumors with identical and previously undescribed histologic features and herein report their morphologic, immunohistochemical, and molecular profiles. Patients were 53, 62, and 79 years. Tumors were well-circumscribed, tan-yellow solid masses measuring 10.0, 11.0, and 18.7 cm, and were intramyometrial (n=2) or in the broad ligament (n=1)...
August 15, 2023: American Journal of Surgical Pathology
#23
JOURNAL ARTICLE
Varvara Mazina, Kyle Devins, Lauren Philp, Alexandra S Bercow, Kaitlyn James, Amy Bregar, Rachel Clark Sisodia, Esther Oliva, Marcela Del Carmen
OBJECTIVE: The primary objective was to characterize the rate of lymph node involvement in a cohort of patients with primary ovarian endometrioid adenocarcinoma. Additionally, we sought to quantify the recurrence rate, genetic alterations, and impact of lymphadenectomy on survival in this group of patients. METHODS: Patients diagnosed with primary endometrioid adenocarcinoma of the ovary without synchronous carcinomas of the female genital tract between 2012 and 2021 were identified...
August 11, 2023: International Journal of Gynecological Cancer
#24
JOURNAL ARTICLE
Loreley Betancourt, Sandy Pico, Estefania Rojas, Maria Jose Gordo, Juan Carlos Oliva, Jaume Almirall, Esther Ponz
BACKGROUND: Intraperitoneal pressure (IPP) in peritoneal dialysis (PD) is an individual characteristic that can be modified by posture and intraperitoneal volume (IPV). It is considered one of the predisposing factors for complications in the abdominal wall, such as the appearance of hernias. No studies to date have confirmed this. The main aim of this study was to assess the relationship between the development of hernia in incident PD patients and IPP measured at PD onset. METHODS: A prospective observational study of incident patients in a PD programme between 2010 and 2020...
August 11, 2023: International Urology and Nephrology
#25
Miguel Ángel Martínez-García, Grace Oscullo, Jose Daniel Gómez-Olivas, Casilda Olveira, Rosa Girón, Marta García-Clemente, Luis Máiz, Oriol Sibila, Rafael Golpe, Juan Luis Rodríguez-Hermosa, Esther Barreiro, Raúl Méndez, Concepción Prados, Juan Rodríguez-López, David de la Rosa
No abstract text is available yet for this article.
July 27, 2023: Archivos de Bronconeumología
#26
JOURNAL ARTICLE
Aaron M Praiss, Douglas Allison, Basile Tessier-Cloutier, Jessica Flynn, Alexia Iasonos, Lien Hoang, Andrei Patrichi, Cristina Terinte, Anna Pesci, Claudia Mateoiu, Ricardo R Lastra, Lucian Puscasiu, Takako Kiyokawa, Rouba Ali-Fehmi, Mira Kheil, Esther Oliva, Kyle M Devins, Nadeem R Abu-Rustum, Robert A Soslow, Simona Stolnicu
OBJECTIVE: We evaluated clinicopathologic parameters of patients with cervical squamous cell carcinoma (SCC) who were treated with initial surgical management and assessed their relation to survival outcomes. Specifically, we evaluated the relation between extent of lymphovascular invasion (LVI) and survival outcomes. METHODS: All available tumor slides from patients with initially surgically treated cervical SCC were collected from 10 institutions and retrospectively analyzed...
September 2023: Gynecologic Oncology
#27
JOURNAL ARTICLE
Ting Zhao, Melanie Kwan, Christian A Barrera, Stuti Shroff, Esther Oliva
Foregut duplication cyst is most commonly seen in the posterior mediastinum without communication with adjacent organs or presence of other malformations and typically shows ectopic gastric or respiratory epithelium. The finding of ectopic pancreatic tissue is extremely rare. A 15-year-old female patient presented with elevated blood pressure, intermittent right flank pain for 18 months. An abdominal MRI revealed a 4 cm right cystic retroperitoneal mass, initially thought to arise from the right adrenal gland...
July 31, 2023: International Journal of Surgical Pathology
#28
RANDOMIZED CONTROLLED TRIAL
Esther Natalie Oliva, Marta Riva, Pasquale Niscola, Valeria Santini, Massimo Breccia, Valentina Giai, Antonella Poloni, Andrea Patriarca, Elena Crisà, Isabella Capodanno, Prassede Salutari, Gianluigi Reda, Nicola Cascavilla, Dario Ferrero, Attilio Guarini, Giovanni Tripepi, Giuseppe Iannì, Emilio Russo, Andrea Castelli, Bruno Fattizzo, Germana Beltrami, Monica Bocchia, Alfredo Molteni, Pierre Fenaux, Ulrich Germing, Alessandra Ricco, Giuseppe A Palumbo, Stefana Impera, Nicola Di Renzo, Flavia Rivellini, Francesco Buccisano, Aspasia Stamatoullas-Bastard, Anna Marina Liberati, Anna Candoni, Ilaria Maria Delfino, Maria Teresa Arcadi, Patrizia Cufari, Lorenzo Rizzo, Irene Bova, Maria Grazia D'Errigo, Gina Zini, Roberto Latagliata
PURPOSE: In myelodysplastic syndromes (MDS), severe thrombocytopenia is associated with poor prognosis. This multicenter trial presents the second-part long-term efficacy and safety results of eltrombopag in patients with low-risk MDS and severe thrombocytopenia. METHODS: In this single-blind, randomized, placebo-controlled, phase-II trial of adult patients with International Prognostic Scoring System low- or intermediate-1-risk MDS, patients with a stable platelet (PLT) count (<30 × 103 /mm3 ) received eltrombopag or placebo until disease progression...
October 1, 2023: Journal of Clinical Oncology
#29
JOURNAL ARTICLE
Junbing Zhang, Claire M Simpson, Jacqueline Berner, Harrison B Chong, Jiafeng Fang, Zehra Ordulu, Tommy Weiss-Sadan, Anthony P Possemato, Stefan Harry, Mariko Takahashi, Tzu-Yi Yang, Marianne Richter, Himani Patel, Abby E Smith, Alexander D Carlin, Adriaan F Hubertus de Groot, Konstantin Wolf, Lei Shi, Ting-Yu Wei, Benedikt R Dürr, Nicholas J Chen, Tristan Vornbäumen, Nina O Wichmann, Mohammed S Mahamdeh, Venkatesh Pooladanda, Yusuke Matoba, Shaan Kumar, Eugene Kim, Sara Bouberhan, Esther Oliva, Bo R Rueda, Roy J Soberman, Nabeel Bardeesy, Brian B Liau, Michael Lawrence, Matt P Stokes, Sean A Beausoleil, Liron Bar-Peled
Multiple anticancer drugs have been proposed to cause cell death, in part, by increasing the steady-state levels of cellular reactive oxygen species (ROS). However, for most of these drugs, exactly how the resultant ROS function and are sensed is poorly understood. It remains unclear which proteins the ROS modify and their roles in drug sensitivity/resistance. To answer these questions, we examined 11 anticancer drugs with an integrated proteogenomic approach identifying not only many unique targets but also shared ones-including ribosomal components, suggesting common mechanisms by which drugs regulate translation...
May 25, 2023: Cell
#30
JOURNAL ARTICLE
Esther Natalie Oliva, Anna Candoni, Prassede Salutari, Giuseppe A Palumbo, Gianluigi Reda, Giuseppe Iannì, Giovanni Tripepi, Maria Cuzzola, Debora Capelli, Corrado Mammì, Caterina Alati, Maria Concetta Cannatà, Pasquale Niscola, Bianca Serio, Pellegrino Musto, Ernesto Vigna, Antonio Volpe, Lorella Maria Antonia Melillo, Maria Teresa Arcadi, Donato Mannina, Maria Elena Zannier, Roberto Latagliata
This phase-3 randomized multicenter trial evaluated the efficacy of subcutaneous azacitidine (AZA) post-remission therapy vs. best supportive care (BSC) in elderly acute myeloid leukemia (AML) patients. The primary endpoint was the difference in disease-free survival (DFS) from complete remission (CR) to relapse/death. Patients with newly diagnosed AML aged ≥61 years received two courses of induction chemotherapy ("3+7" daunorubicin and cytarabine) followed by consolidation (cytarabine). At CR, 54 patients were randomized (1:1) to receive BSC (N = 27) or AZA (N = 27) at a dose of 50 mg/m2 for 7 days every 28 days and the dose increased after the 1st cycle to 75 mg/m2 for a further 5 cycles, followed by cycles every 56 days for 4...
April 24, 2023: Cancers
#31
REVIEW
Madeleine Sertic, Kyle M Devins, Esther Oliva, Susanna I Lee, Aoife Kilcoyne
Ovarian sex cord-stromal tumors (OSCSTs) are a rare group of ovarian neoplasms that can be benign or malignant. They are classified into pure sex cord tumors, pure stromal tumors, and mixed SCST. The most common malignant OSCSTs are adult granulosa cell tumors. In contrast to the more common ovarian epithelial malignancies, OSCSTs present in younger patients, often at early stages, with better prognoses. Imaging features are variable, and pathology is required for diagnosis. However, certain tumors demonstrate characteristic imaging appearances that can be useful in narrowing the differential diagnosis...
July 2023: Radiologic Clinics of North America
#32
JOURNAL ARTICLE
Ana Fernández Montes, Vicente Alonso Orduña, Elena Asensio Martínez, Nuria Rodríguez Salas, Esperanza Torres, Diego Cacho Lavín, Rosa María Rodríguez Alonso, Esther Falcó, Joan Carles Oliva, Lluis Cirera, Jesus García Gómez, Carles Pericay
BACKGROUND: Patients with metastatic colorectal cancer (mCRC) and KRAS mutations have a poor prognosis, seemingly dependent on the location of the mutation. This multicenter, retrospective, cohort study assessed the frequency and prognostic value of specific KRAS mutation codon locations in mCRC patients, and survival outcomes in relation to treatment. MATERIALS AND METHODS: Data from mCRC patients treated in 10 Spanish hospitals between January 2011 and December 2015 were analyzed...
May 4, 2023: Oncologist
#33
JOURNAL ARTICLE
Maria Domenica Cappellini, Ali T Taher, Antonio Piga, Farrukh Shah, Ersi Voskaridou, Vip Viprakasit, John B Porter, Olivier Hermine, Ellis J Neufeld, Alexis A Thompson, Derek Tang, Aylin Yucel, Jennifer Lord-Bessen, Peiwen Yu, Shien Guo, Jeevan K Shetty, Dimana Miteva, Tatiana Zinger, Jay T Backstrom, Esther Natalie Oliva
BACKGROUND: Patients with transfusion-dependent (TD) β-thalassemia require long-term red blood cell transfusions (RBCTs) that lead to iron overload, impacting health-related quality of life (HRQoL). METHODS: The impact of luspatercept, a first-in-class erythroid maturation agent, versus placebo on HRQoL of patients with TD β-thalassemia was evaluated in the phase 3 BELIEVE trial. HRQoL was assessed at baseline and every 12 weeks using the 36-item Short Form Health Survey (SF-36) and Transfusion-dependent Quality of Life questionnaire (TranQol)...
April 24, 2023: European Journal of Haematology
#34
JOURNAL ARTICLE
Kyle M Devins, Ayoma D Attygalle, Sabrina Croce, Katherine Vroobel, Esther Oliva, W Glenn McCluggage
Uterine endometrial stromal sarcomas (ESS) with YWHAE::NUTM2 gene fusions are typically morphologically high-grade tumors composed of atypical round cells, sometimes associated with a low-grade fibromyxoid component; they are currently included in the category of high-grade ESS (HGESS). We report 5 morphologically pure low-grade endometrial stromal tumors harboring YWHAE::NUTM2 fusions, including 1 endometrial stromal nodule (ESN) and 4 low-grade endometrial stromal sarcomas (LGESS), an association only occasionally reported previously...
June 1, 2023: American Journal of Surgical Pathology
#35
JOURNAL ARTICLE
Valentin Junet, Pedro Matos-Filipe, Juan Manuel García-Illarramendi, Esther Ramírez, Baldo Oliva, Judith Farrés, Xavier Daura, José Manuel Mas, Rafael Morales
Oncology treatments require continuous individual adjustment based on the measurement of multiple clinical parameters. Prediction tools exploiting the patterns present in the clinical data could be used to assist decision making and ease the burden associated to the interpretation of all these parameters. The goal of this study was to predict the evolution of patients with pancreatic cancer at their next visit using information routinely recorded in health records, providing a decision-support system for clinicians...
March 31, 2023: CPT: Pharmacometrics & Systems Pharmacology
#36
JOURNAL ARTICLE
Esther López Jiménez, Marta Neira Álvarez, Raquel Ramírez Martín, Cristina Alonso Bouzón, María Solange Amor Andrés, Cristina Bermejo Boixareu, Fátima Brañas, Rocío Menéndez Colino, Estefanía Arias Muñana, Marta Checa López, Concha Grau Jiménez, Patricia Pérez Rodríguez, María Alcantud Ibáñez, Brian Vasquez Brolen, Juan Oliva, Luz María Peña Longobardo, Rubén Alcantud Córcoles, Elisa Belén Cortés Zamora, Elena Gómez Jiménez, Luis Romero Rizos, Almudena Avendaño Céspedes, Carmen Rosa Hernández Socorro, Pedro Abizanda
BACKGROUND: Measurement of muscle mass and function, and thereafter, screening and diagnosis of sarcopenia, is a challenge and a need in hospitalized older adults. However, it is difficult in complex real-world old patients, because usually they are unable to collaborate with clinical, functional, and imaging testing. Ultrasound measurement of quadriceps rectus femoris (QRF) provides a non-invasive, real-time assessment of muscle quantity and quality, and is highly acceptable to participants with excellent inter-rater and intra-rater variability...
March 22, 2023: BMC Geriatrics
#37
JOURNAL ARTICLE
Elisabetta Sauta, Marie Robin, Matteo Bersanelli, Erica Travaglino, Manja Meggendorfer, Lin-Pierre Zhao, Juan Carlos Caballero Berrocal, Claudia Sala, Giulia Maggioni, Massimo Bernardi, Carmen Di Grazia, Luca Vago, Giulia Rivoli, Lorenza Borin, Saverio D'Amico, Cristina Astrid Tentori, Marta Ubezio, Alessia Campagna, Antonio Russo, Daniele Mannina, Luca Lanino, Patrizia Chiusolo, Luisa Giaccone, Maria Teresa Voso, Marta Riva, Esther Natalie Oliva, Matteo Zampini, Elena Riva, Olivier Nibourel, Marilena Bicchieri, Niccolo' Bolli, Alessandro Rambaldi, Francesco Passamonti, Victor Savevski, Armando Santoro, Ulrich Germing, Shahram Kordasti, Valeria Santini, Maria Diez-Campelo, Guillermo Sanz, Francesc Sole, Wolfgang Kern, Uwe Platzbecker, Lionel Ades, Pierre Fenaux, Torsten Haferlach, Gastone Castellani, Matteo Giovanni Della Porta
PURPOSE: Myelodysplastic syndromes (MDS) are heterogeneous myeloid neoplasms in which a risk-adapted treatment strategy is needed. Recently, a new clinical-molecular prognostic model, the Molecular International Prognostic Scoring System (IPSS-M) was proposed to improve the prediction of clinical outcome of the currently available tool (Revised International Prognostic Scoring System [IPSS-R]). We aimed to provide an extensive validation of IPSS-M. METHODS: A total of 2,876 patients with primary MDS from the GenoMed4All consortium were retrospectively analyzed...
May 20, 2023: Journal of Clinical Oncology
#38
JOURNAL ARTICLE
Karima Al-Akioui Sanz, Carlos Echecopar Parente, Cristina Ferreras, Marta Menéndez Ribes, Alfonso Navarro, Carmen Mestre, Laura Clares, José Luis Vicario, Antonio Balas, Raquel De Paz, Eduardo López Granados, Elena Sánchez Zapardiel, Carlos Jiménez, María López-Oliva, Esther Ramos, Francisco Hernández-Oliveros, Antonio Pérez-Martínez
BACKGROUND: Immunocompromised patients are susceptible to high-risk opportunistic infections and malignant diseases. Most antiviral and antifungal drugs are quite toxic, relatively ineffective, and induce resistance in the long term. The transfer of pathogen-specific Cytotoxic T-Lymphocytes has shown a minimal toxicity profile and effectiveness in treating Cytomegalovirus, Adenovirus, Epstein - Barr virus, BK Virus and Aspergillus infections, but this therapy have the main limitations of regulatory issues, high cost, and absence of public cell banks...
2023: Frontiers in Medicine
#39
Miguel Ángel Frutos, Marta Crespo, María de la Oliva Valentín, Ángel Alonso-Melgar, Juana Alonso, Constantino Fernández, Gorka García-Erauzkin, Esther González, Ana M González-Rinne, Lluis Guirado, Alex Gutiérrez-Dalmau, Jorge Huguet, José Luis López Del Moral, Mireia Musquera, David Paredes, Dolores Redondo, Ignacio Revuelta, Carlos J Van-der Hofstadt, Antonio Alcaraz, Ángel Alonso-Hernández, Manuel Alonso, Purificación Bernabeu, Gabriel Bernal, Alberto Breda, Mercedes Cabello, José Luis Caro-Oleas, Joan Cid, Fritz Diekmann, Laura Espinosa, Carme Facundo, Marta García, Salvador Gil-Vernet, Miquel Lozano, Beatriz Mahillo, María José Martínez, Blanca Miranda, Federico Oppenheimer, Eduard Palou, María José Pérez-Saez, Lluis Peri, Oscar Rodríguez, Carlos Santiago, Guadalupe Tabernero, Domingo Hernández, Beatriz Domínguez-Gil, Julio Pascual
No abstract text is available yet for this article.
February 24, 2023: Nefrología
#40
JOURNAL ARTICLE
Parnian A Moghaddam, Robert H Young, Nadia D Ismiil, Jennifer A Bennett, Esther Oliva
Endometrial stromal tumors represent the second most common category of uterine mesenchymal tumors. Several different histologic variants and underlying genetic alterations have been recognized, one such being a group associated with BCORL1 rearrangements. They are usually high-grade endometrial stromal sarcomas, often associated with prominent myxoid background and aggressive behavior. Here, we report an unusual endometrial stromal neoplasm with JAZF1-BCORL1 rearrangement and briefly review the literature...
January 23, 2023: International Journal of Gynecological Pathology
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