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https://www.readbyqxmd.com/read/27915441/ovarian-metastasis-from-uveal-melanoma-with-mlh1-pms2-protein-loss-in-a-patient-with-germline-mlh1-mutated-lynch-syndrome-consequence-or-coincidence
#1
João Lobo, Carla Pinto, Micaela Freitas, Manuela Pinheiro, Rámon Vizcaino, Esther Oliva, Manuel R Teixeira, Carmen Jerónimo, Carla Bartosch
Currently, uveal melanoma is not considered within the Lynch syndrome tumor spectrum. However, there are studies suggesting a contribution of microsatellite instability in sporadic uveal melanoma tumorigenesis. We report a 45-year-old woman who was referred for genetic counseling due to a family history of Lynch syndrome caused by a MLH1 mutation. She originally underwent enucleation of the right eye secondary to a uveal spindle cell melanoma diagnosed at age 25. The tumor recurred 22 years later presenting as an ovarian metastasis and concurrently a microscopic endometrial endometrioid carcinoma, grade 1/3 was diagnosed...
December 3, 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27895324/molecular-genetic-heterogeneity-in-undifferentiated-endometrial-carcinomas
#2
Juan M Rosa-Rosa, Susanna Leskelä, Eva Cristóbal-Lana, Almudena Santón, Ma Ángeles López-García, Gloria Muñoz, Belen Pérez-Mies, Michele Biscuola, Jaime Prat, Oliva E Esther, Robert A Soslow, Xavier Matias-Guiu, Jose Palacios
No abstract text is available yet for this article.
December 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27801954/the-who-2016-classification-of-testicular-non-germ-cell-tumours-a-review-and-update-from-the-international-society-of-urological-pathology-testis-consultation-panel
#3
REVIEW
Muhammad T Idrees, Thomas M Ulbright, Esther Oliva, Robert H Young, Rodolfo Montironi, Lars Egevad, Daniel Berney, John R Srigley, Jonathan I Epstein, Satish K Tickoo
The World Health Organization (WHO) released a new tumour classification for the genitourinary system in early 2016 after consensus by pathologists with expertise in these organs. It utilized the framework of the 2004 classification and incorporated the most up-to-date information concerning these tumours. In testicular tumours, the majority of the changes occurred in the nomenclature and classification of the germ cell tumours; however, several modifications were also initiated for the non-germ cell tumours...
November 1, 2016: Histopathology
https://www.readbyqxmd.com/read/27743968/-respiratory-viral-infections-in-a-cohort-of-children-during-the-first-year-of-life-and-their-role-in-the-development-of-wheezing
#4
Cristina Calvo, Isabel Aguado, María Luz García-García, Esther Ruiz-Chercoles, Eloisa Díaz-Martinez, Rosa María Albañil, Olga Campelo, Antonio Olivas, Luisa Muñóz-Gonzalez, Francisco Pozo, Rosa Fernandez-Arroyo, Adelaida Fernandez-Rincón, Ana Calderon, Inmaculada Casas
INTRODUCTION: It is known that infants with viral respiratory infections severe enough to require hospital admission have a high risk of developing recurrent wheezing. Few data have been published on unselected populations. The main aim of this study was to analyse symptomatic and asymptomatic respiratory viral infections during the first year of life in a cohort of infants, recruited at birth, and the development of recurrent wheezing. PATIENTS AND METHODS: A total of 302 newborns were recruited...
October 13, 2016: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/27677378/advancing-vector-biology-research-a-community-survey-for-future-directions-research-applications-and-infrastructure-requirements
#5
Alain Kohl, Emilie Pondeville, Esther Schnettler, Andrea Crisanti, Clelia Supparo, George K Christophides, Paul J Kersey, Gareth L Maslen, Willem Takken, Constantianus J M Koenraadt, Clelia F Oliva, Núria Busquets, F Xavier Abad, Anna-Bella Failloux, Elena A Levashina, Anthony J Wilson, Eva Veronesi, Maëlle Pichard, Sarah Arnaud Marsh, Frédéric Simard, Kenneth D Vernick
Vector-borne pathogens impact public health, animal production, and animal welfare. Research on arthropod vectors such as mosquitoes, ticks, sandflies, and midges which transmit pathogens to humans and economically important animals is crucial for development of new control measures that target transmission by the vector. While insecticides are an important part of this arsenal, appearance of resistance mechanisms is increasingly common. Novel tools for genetic manipulation of vectors, use of Wolbachia endosymbiotic bacteria, and other biological control mechanisms to prevent pathogen transmission have led to promising new intervention strategies, adding to strong interest in vector biology and genetics as well as vector-pathogen interactions...
June 2016: Pathogens and Global Health
https://www.readbyqxmd.com/read/27575783/usefulness-of-speckle-myocardial-imaging-modalities-for-differential-diagnosis-of-left-ventricular-non-compaction-of-the-myocardium
#6
Marcelino Cortés, María Reyes Oliva, Miguel Orejas, Miguel Angel Navas, Rosa María Rábago, Maria Esther Martínez, Mikel Taibo, Julia Palfy, Manuel Rey, Jerónimo Farré
BACKGROUND/OBJECTIVES: Current diagnostic criteria for left ventricular non-compaction (LVNC) may result in over-diagnosis of the disease. We evaluate the role of speckle imaging in differential diagnosis of LVNC. METHODS AND RESULTS: We included all patients who, between January 2012 and May 2015, fulfilled currently accepted criteria for LVNC (28 patients). A control group of 28 healthy individuals and a third group of 13 patients with dilated cardiomyopathy (DCM) were created...
November 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27491810/molecular-genetic-heterogeneity-in-undifferentiated-endometrial-carcinomas
#7
Juan M Rosa-Rosa, Susanna Leskelä, Eva Cristóbal-Lana, Almudena Santón, Ma Ángeles López-García, Gloria Muñoz, Belen Pérez-Mies, Michele Biscuola, Jaime Prat, Oliva E Esther, Robert A Soslow, Xavier Matias-Guiu, Jose Palacios
Undifferentiated and dedifferentiated endometrial carcinomas are rare and highly aggressive subtypes of uterine cancer, not well characterized at a molecular level. To investigate whether dedifferentiated carcinomas carry molecular genetic alterations similar to those of pure undifferentiated carcinomas, and to gain insight into the pathogenesis of these tumors, we selected a cohort of 18 undifferentiated endometrial carcinomas, 8 of them with a well-differentiated endometrioid carcinoma component (dedifferentiated endometrioid carcinomas), and studied them by immunohistochemistry and massive parallel and Sanger sequencing...
August 5, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27365458/patient-centered-research-and-practice-in-the-era-of-genomics-a-novel-approach
#8
EDITORIAL
Sam Salek, Esther Oliva, Tatyana Ionova
No abstract text is available yet for this article.
July 2016: Haematologica
https://www.readbyqxmd.com/read/27340748/primary-endometrial-marginal-zone-lymphoma-malt-lymphoma-a-unique-clinicopathologic-entity
#9
Jennifer A Bennett, Esther Oliva, Valentina Nardi, Neal Lindeman, Judith A Ferry, Abner Louissaint
Primary lymphoma of the endometrium is exceptionally rare. Several cases of distinctly nodular lymphoid proliferations confined to the endometrium have previously been described and reported as lymphomas of mucosa-associated lymphoid tissue (MALT). We report the largest series (n=8) of these lymphomas, further defining their morphologic, immunohistochemical, and molecular spectrum. Patients ranged in age from 50 to 87 (median, 62) years. None had a prior history of lymphoma, and lesions were incidental in all but 1 in which a polyp was noted on macroscopic examination...
September 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27340747/pathologic-findings-in-prophylactic-and-nonprophylactic-hysterectomy-specimens-of-patients-with-lynch-syndrome
#10
Carla Bartosch, Ana S Pires-Luís, Catarina Meireles, Manuela Baptista, Alfredo Gouveia, Carla Pinto, Kristen M Shannon, Carmen Jerónimo, Manuel R Teixeira, José M Lopes, Esther Oliva
Women with Lynch syndrome (LS) have a high risk of developing endometrial carcinoma (EC) and, less frequently, ovarian carcinoma. As EC not uncommonly is the first malignancy, prophylactic hysterectomy (PH) has been increasingly implemented. In this study, we report the clinicopathologic features of a series of 70 LS patients who underwent either PH (n=39) or nonprophylactic hysterectomy (NPH) (n=31) at 3 tertiary referral centers. Among the 39 patients with PH, 2 had endometrial tumors seen grossly, whereas 37 showed no macroscopic lesions...
September 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27294874/a-calcium-and-calpain-dependent-pathway-determines-the-response-to-lenalidomide-in-myelodysplastic-syndromes
#11
Jing Fang, Xiaona Liu, Lyndsey Bolanos, Brenden Barker, Carmela Rigolino, Agostino Cortelezzi, Esther N Oliva, Maria Cuzzola, H Leighton Grimes, Celia Fontanillo, Kakajan Komurov, Kyle MacBeth, Daniel T Starczynowski
Despite the high response rates of individuals with myelodysplastic syndrome (MDS) with deletion of chromosome 5q (del(5q)) to treatment with lenalidomide (LEN) and the recent identification of cereblon (CRBN) as the molecular target of LEN, the cellular mechanism by which LEN eliminates MDS clones remains elusive. Here we performed an RNA interference screen to delineate gene regulatory networks that mediate LEN responsiveness in an MDS cell line, MDSL. We identified GPR68, which encodes a G-protein-coupled receptor that has been implicated in calcium metabolism, as the top candidate gene for modulating sensitivity to LEN...
July 2016: Nature Medicine
https://www.readbyqxmd.com/read/27268231/-poisoning-by-illegal-drugs-in-young-children-in-spanish-paediatric-emergency-departments
#12
Beatriz Azkunaga, Esther Crespo, Silvia Oliva, Javier Humayor, Liliana Mangione
No abstract text is available yet for this article.
June 4, 2016: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/27097978/differential-expression-of-e-cadherin-and-catenins-in-ovarian-sex-cord-stromal-tumours
#13
Stavroula Stavrinou, Ashleigh Clark, Julie Irving, Cheng-Han Lee, Esther Oliva, Robert Young, Ruethairat Sriraksa, Nesreen Magdy, Susan Van Noorden, W Glenn McCluggage, Mona El-Bahrawy
AIMS: Sex cord stromal tumours (SCSTs) of the ovary encompass several histological tumour subtypes that are defined by characteristic histological features. Some can show morphological overlap with other subtypes of SCSTs, as well as with non-SCSTs. The E-cadherin/catenin complex constitutes the adherens junction, which is well developed in epithelial tissue, but the constituent molecules are also expressed in several non-epithelial tumours. The aim of this study was to determine whether the expression patterns of E-cadherin and catenins in ovarian SCSTs can be of diagnostic utility...
August 2016: Histopathology
https://www.readbyqxmd.com/read/26838783/preface
#14
EDITORIAL
Esther Oliva
No abstract text is available yet for this article.
December 2009: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/26838778/miscellaneous-pseudotumors-and-mesenchymal-tumors-of-the-female-genital-tract
#15
REVIEW
Koen K Van de Vijver, Esther Oliva
Benign and malignant soft tissue tumors and pseudotumors can rarely arise anywhere in the female genital tract. Their pathologic features as well as behavior typically overlap with those described in tumors involving typical locations. However, due to their rarity, not infrequently these tumors represent a diagnostic challenge. Their diagnosis should be based on careful gross examination, thorough sampling, and morphologic evaluation, applying a selected immunohistochemical panel and molecular studies. Accurate classification of these tumors is important because their clinical behavior, prognosis, and therapy differ markedly...
December 2009: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/26838775/endometrial-ioid-stromal-tumors-and-related-neoplasms-of-the-female-genital-tract
#16
REVIEW
Esther Oliva, Patricia M Baker
Endometrial/ioid stromal tumors comprise a spectrum of mesenchymal neoplasms, ranging from benign to low-grade malignancy to undifferentiated sarcomas, which occur predominantly in the uterus but may rarely originate at extrauterine sites, most commonly in the ovary. These tumors and their morphologic variants are important to recognize as they often cause diagnostic difficulties. This review focuses on the diagnostic criteria and differential diagnosis, including the role of immunohistochemistry.
December 2009: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/26837293/high-grade-endometrial-carcinomas
#17
REVIEW
Esther Oliva, Robert A Soslow
High-grade endometrial carcinomas are a heterogeneous group of clinically aggressive tumors. They include FIGO grade 3 endometrioid carcinoma, serous carcinoma, clear cell carcinoma, undifferentiated carcinoma, and malignant mixed Müllerian tumor (MMMT). Epidemiologic, genetic, biologic prognostic and morphologic differences between these entities are striking in prototypic cases, yet substantial overlap exists and diagnostic criteria and therapeutic approaches that account for the group's diversity are currently insufficient...
March 2011: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/26818147/real-life-experience-with-liver-iron-concentration-r2-mri-measurement-in-patients-with-hemoglobinopathies-baseline-data-from-licnet
#18
Angela Vitrano, Giuseppina Calvaruso, Lorenzo Tesé, Francesco Gioia, Filippo Cassarà, Saveria Campisi, Franco Butera, Valeria Commendatore, Michele Rizzo, Vincenzo Santoro, Valeria Cigna, Alessandra Quota, Sabrina Bagnato, Crocetta Argento, Carmelo Fidone, Dario Schembari, Calogera Gerardi, Filippo Barbiera, Giuseppe Bellisssima, Giovanni Giugno, Gesualdo Polizzi, Rosamaria Rosso, Giovanna Abbate, Vincenzo Caruso, Elisabetta Chiodi, Maria Rita Gamberini, Benedetta Giorgi, Maria Caterina Putti, Aldo Filosa, Maria Rosaria De Ritis, Esther Oliva, Nicola Arcadi, Maria Fustaneo, Laura Mistretta, Rosario Di Maggio, Massimiliano Sacco, Di Salvo Veronica, Antonino Giangreco, Aurelio Maggio
BACKGROUND: Real-life data on the use of R2 MRI for the assessment of liver iron concentration (LIC) remain limited. METHODS: We conducted a cross-sectional analysis on 363 patients (mean age 35.6 yr, 44.1% men) with hemoglobinopathies (204 β-thalassemia major [TM], 102 β-thalassemia intermedia [TI], and 57 sickle cell disease [SCD]) that were evaluated with R2 MRI as part of LICNET, an MRI network of 13 Italian treatment centers. RESULTS: The mean LIC was 7...
October 2016: European Journal of Haematology
https://www.readbyqxmd.com/read/26813747/mismatch-repair-protein-expression-in-clear-cell-carcinoma-of-the-ovary-incidence-and-morphologic-associations-in-109-cases
#19
MULTICENTER STUDY
Jennifer A Bennett, Vicente Morales-Oyarvide, Sharon Campbell, Teri A Longacre, Esther Oliva
Several morphologic features have been reported to be predictive of abnormal expression of mismatch repair (MMR) proteins in endometrial and colon carcinomas. Although it is known that abnormal MMR expression is increased in frequency in ovarian endometrioid and clear cell carcinomas, no such histologic correlation has been identified. We reviewed 109 unselected ovarian clear cell carcinomas for specific tumor characteristics (architecture, nuclear atypia, signet ring cells, stromal hyalinization, background precursor) and inflammatory response (peritumoral lymphocytes found along the leading edge of the tumor, intratumoral stromal inflammation found within the tumor, percentage of plasma cells in the intratumoral stromal inflammation, tumor-infiltrating lymphocytes) and performed immunohistochemistry for all 4 MMR proteins...
May 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/26715170/practical-issues-in-uterine-pathology-from-banal-to-bewildering-the-remarkable-spectrum-of-smooth-muscle-neoplasia
#20
REVIEW
Esther Oliva
Among mesenchymal tumors of the uterus, smooth muscle neoplasms are most common. The wide morphologic spectrum, especially within the category of leiomyomas, is responsible for diagnostic problems more frequently with leiomyosarcoma (including mitotically active, apoplectic, and leiomyoma with bizarre nuclei) but also with endometrial stromal tumors. In the former scenario, clinical information, gross appearance as well as strict utilization of morphologic criteria including cytologic atypia, mitotic activity, and tumor cell necrosis are clues in establishing the correct diagnosis...
January 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
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