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https://www.readbyqxmd.com/read/29915083/early-loss-of-mitochondrial-complex-i-and-rewiring-of-glutathione-metabolism-in-renal-oncocytoma
#1
Raj K Gopal, Sarah E Calvo, Angela R Shih, Frances L Chaves, Declan McGuone, Eran Mick, Kerry A Pierce, Yang Li, Andrea Garofalo, Eliezer M Van Allen, Clary B Clish, Esther Oliva, Vamsi K Mootha
Renal oncocytomas are benign tumors characterized by a marked accumulation of mitochondria. We report a combined exome, transcriptome, and metabolome analysis of these tumors. Joint analysis of the nuclear and mitochondrial (mtDNA) genomes reveals loss-of-function mtDNA mutations occurring at high variant allele fractions, consistent with positive selection, in genes encoding complex I as the most frequent genetic events. A subset of these tumors also exhibits chromosome 1 loss and/or cyclin D1 overexpression, suggesting they follow complex I loss...
June 18, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29895954/a-phase-3-randomized-placebo-controlled-study-assessing-the-efficacy-and-safety-of-epoetin-%C3%AE-in-anemic-patients-with-low-risk-mds
#2
Pierre Fenaux, Valeria Santini, Maria Antonietta Aloe Spiriti, Aristoteles Giagounidis, Rudolf Schlag, Atanas Radinoff, Liana Gercheva-Kyuchukova, Achilles Anagnostopoulos, Esther Natalie Oliva, Argiris Symeonidis, Mathilde Hunault Berger, Katharina S Götze, Anna Potamianou, Hari Haralampiev, Robert Wapenaar, Iordanis Milionis, Uwe Platzbecker
Erythropoiesis-stimulating agents are first choice for treating anemia in low-risk MDS. This double-blind, placebo-controlled study assessed the efficacy and safety of epoetin-α in IPSS low- or intermediate-1 risk (i.e., low-risk) MDS patients with Hb ≤ 10.0 g/dL, with no or moderate RBC transfusion dependence (≤4 RBC units/8 weeks). Patients were randomized, 2:1, to receive epoetin-α 450 IU/kg/week or placebo for 24 weeks, followed by treatment extension in responders. The primary endpoint was erythroid response (ER) through Week 24...
March 30, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29877920/international-endocervical-adenocarcinoma-criteria-and-classification-validation-and-interobserver-reproducibility
#3
Anjelica Hodgson, Kay J Park, Bojana Djordjevic, Brooke E Howitt, Marisa R Nucci, Esther Oliva, Simona Stolnicu, Bin Xu, Robert A Soslow, Carlos Parra-Herran
The current World Health Organization (WHO) classification for endocervical adenocarcinoma (EA) is based on descriptive morphologic characteristics; however, it does not fully reflect our current knowledge of the diverse pathogenesis of cervical glandular neoplasia. A novel classification system, the International Endocervical Adenocarcinoma Criteria and Classification (IECC), which incorporates etiology and biological behavior into the morphologic scheme, has been recently proposed. We aimed to validate the IECC by assessing its interobserver reproducibility in comparison to the WHO system...
June 5, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29851704/diagnostic-algorithmic-proposal-based-on-comprehensive-immunohistochemical-evaluation-of-297-invasive-endocervical-adenocarcinomas
#4
Simona Stolnicu, Iulia Barsan, Lien Hoang, Prusha Patel, Luis Chiriboga, Cristina Terinte, Anna Pesci, Sarit Aviel-Ronen, Takako Kiyokawa, Isabel Alvarado-Cabrero, Malcolm C Pike, Esther Oliva, Kay J Park, Robert A Soslow
The International Endocervical Adenocarcinoma Criteria and Classification was developed to separate endocervical adenocarcinomas (ECAs) into 2 main categories on the basis of morphology such as human papilloma virus-associated (HPVA) and non-human papilloma virus-associated adenocarcinomas. We aimed to improve the diagnostic accuracy of International Endocervical Adenocarcinoma Criteria and Classification by performing a comprehensive immunohistochemical evaluation and constructing objective immunohistochemical-based algorithms for the classification of these tumors...
May 30, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29750335/universal-screening-of-both-endometrial-and-colon-cancers-increases-the-detection-of-lynch-syndrome
#5
Tomer Adar, Linda H Rodgers, Kristen M Shannon, Makoto Yoshida, Tianle Ma, Anthony Mattia, Gregory Y Lauwers, Anthony J Iafrate, Nicole M Hartford, Esther Oliva, Daniel C Chung
BACKGROUND: Lynch syndrome (LS) is the most common hereditary cause of colorectal cancer (CRC) and endometrial cancer (EC). Screening of all CRCs for LS is currently recommended, but screening of ECs is inconsistent. The objective of this study was to determine the added value of screening both CRC and EC tumors in the same population. METHODS: A prospective, immunohistochemistry (IHC)-based screening program for all patients with newly diagnosed CRCs and ECs was initiated in 2011 and 2013, respectively, at 2 centers (primary and tertiary)...
May 11, 2018: Cancer
https://www.readbyqxmd.com/read/29728212/-admission-discharge-and-triage-guidelines-for-paediatric-intensive-care-units-in-spain
#6
Pedro de la Oliva, Francisco José Cambra-Lasaosa, Manuel Quintana-Díaz, Corsino Rey-Galán, Juan Ignacio Sánchez-Díaz, María Cruz Martín-Delgado, Juan Carlos de Carlos-Vicente, Ramón Hernández-Rastrollo, María Soledad Holanda-Peña, Francisco Javier Pilar-Orive, Esther Ocete-Hita, Antonio Rodríguez-Núñez, Ana Serrano-González, Luis Blanch
A paediatric intensive care unit (PICU) is a separate physical facility or unit specifically designed for the treatment of paediatric patients who, because of the severity of illness or other life-threatening conditions, require comprehensive and continuous inten-sive care by a medical team with special skills in paediatric intensive care medicine. Timely and personal intervention in intensive care reduces mortality, reduces length of stay, and decreases cost of care. With the aim of defending the right of the child to receive the highest attainable standard of health and the facilities for the treatment of illness and rehabilitation, as well as ensuring the quality of care and the safety of critically ill paediatric patients, the Spanish Association of Paediatrics (AEP), Spanish Society of Paediatric Intensive Care (SECIP) and Spanish Society of Critical Care (SEMICYUC) have approved the guidelines for the admission, discharge and triage for Spanish PICUs...
May 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29699643/admission-discharge-and-triage-guidelines-for-paediatric-intensive-care-units-in-spain
#7
Pedro de la Oliva, Francisco José Cambra-Lasaosa, Manuel Quintana-Díaz, Corsino Rey-Galán, Juan Ignacio Sánchez-Díaz, María Cruz Martín-Delgado, Juan Carlos de Carlos-Vicente, Ramón Hernández-Rastrollo, María Soledad Holanda-Peña, Francisco Javier Pilar-Orive, Esther Ocete-Hita, Antonio Rodríguez-Núñez, Ana Serrano-González, Luis Blanch
A paediatric intensive care unit (PICU) is a separate physical facility or unit specifically designed for the treatment of paediatric patients who, because of the severity of illness or other life-threatening conditions, require comprehensive and continuous inten-sive care by a medical team with special skills in paediatric intensive care medicine. Timely and personal intervention in intensive care reduces mortality, reduces length of stay, and decreases cost of care. With the aim of defending the right of the child to receive the highest attainable standard of health and the facilities for the treatment of illness and rehabilitation, as well as ensuring the quality of care and the safety of critically ill paediatric patients, the Spanish Association of Paediatrics (AEP), Spanish Society of Paediatric Intensive Care (SECIP) and Spanish Society of Critical Care (SEMICYUC) have approved the guidelines for the admission, discharge and triage for Spanish PICUs...
May 2018: Medicina Intensiva
https://www.readbyqxmd.com/read/29620586/predictive-histologic-factors-in-carcinosarcomas-of-the-uterus-a-multiinstitutional-study
#8
Eman Abdulfatah, Leonardo Lordello, Muhammad Khurram, Koen Van de Vijver, Baraa Alosh, Sudeshna Bandyopadhyay, Esther Oliva, Rouba Ali-Fehmi
Uterine carcinosarcomas are rare aggressive biphasic neoplasms. Because of its rarity, limited data are available on potential prognostic parameters. While several studies support that carcinomatous components predict outcomes, others do not. In this study, we evaluated the clinical and histopathologic features of 196 uterine carcinosarcomas to identify potential prognostic factors. Patients' ages ranged from 34 to 95 yr (median, 68 yr). Seventy-three (38%) patients experienced tumor recurrence during follow-up...
April 3, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29553955/ntrk-fusions-define-a-novel-uterine-sarcoma-subtype-with-features-of-fibrosarcoma
#9
Sarah Chiang, Paolo Cotzia, David M Hyman, Alexander Drilon, William D Tap, Lei Zhang, Jaclyn F Hechtman, Denise Frosina, Achim A Jungbluth, Rajmohan Murali, Kay J Park, Robert A Soslow, Esther Oliva, A John Iafrate, Ryma Benayed, Marc Ladanyi, Cristina R Antonescu
Tropomyosin receptor kinase (Trk) inhibitors have shown high response rates in patients with tumors harboring NTRK fusions. We identified 4 NTRK fusion-positive uterine sarcomas that should be distinguished from leiomyosarcoma and undifferentiated uterine sarcoma. NTRK rearrangements were detected by fluorescence in situ hybridization (FISH) and/or targeted RNA or DNA sequencing in 4 undifferentiated uterine sarcomas with spindle cell morphology. Because of histologic overlap with leiomyosarcoma, TrkA and pan-Trk immunohistochemistry was performed in 97 uterine leiomyosarcomas...
June 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29521846/withdrawn-international-society-of-gynecological-pathologists-isgyp-endometrial-cancer-project-guidelines-from-the-special-techniques-and-ancillary-studies-group
#10
Kathleen R Cho, Kumarasen Cooper, Sabrina Croce, Bojana Djordevic, Simon Herrington, Brooke Howitt, Pei Hui, Philip Ip, Martin Koebel, Sigurd Lax, Bradley J Quade, Patricia Shaw, August Vidal, Anna Yemelyanova, Blaise Clarke, Lora Hedrick Ellenson, Teri A Longacre, Ie-Ming Shih, W Glenn McCluggage, Anais Malpica, Esther Oliva, Vinita Parkash, Xavier Matias-Guiu
Ahead of Print article withdrawn by publisher.
April 11, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29505428/molecular-classification-of-grade-3-endometrioid-endometrial-cancers-identifies-distinct-prognostic-subgroups
#11
Tjalling Bosse, Remi A Nout, Jessica N McAlpine, Melissa K McConechy, Heidi Britton, Yaser R Hussein, Carlene Gonzalez, Raji Ganesan, Jane C Steele, Beth T Harrison, Esther Oliva, August Vidal, Xavier Matias-Guiu, Nadeem R Abu-Rustum, Douglas A Levine, C Blake Gilks, Robert A Soslow
Our aim was to investigate whether molecular classification can be used to refine prognosis in grade 3 endometrial endometrioid carcinomas (EECs). Grade 3 EECs were classified into 4 subgroups: p53 abnormal, based on mutant-like immunostaining (p53abn); MMR deficient, based on loss of mismatch repair protein expression (MMRd); presence of POLE exonuclease domain hotspot mutation (POLE); no specific molecular profile (NSMP), in which none of these aberrations were present. Overall survival (OS) and recurrence-free survival (RFS) rates were compared using the Kaplan-Meier method (Log-rank test) and univariable and multivariable Cox proportional hazard models...
May 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29449679/tert-promoter-mutation-in-adult-granulosa-cell-tumor-of-the-ovary
#12
Jessica A Pilsworth, Dawn R Cochrane, Zhouchunyang Xia, Geraldine Aubert, Anniina E M Färkkilä, Hugo M Horlings, Satoshi Yanagida, Winnie Yang, Jamie L P Lim, Yi Kan Wang, Ali Bashashati, Jacqueline Keul, Adele Wong, Kevin Norris, Sara Y Brucker, Florin-Andrei Taran, Bernhard Krämer, Annette Staebler, Esther Oliva, Sohrab P Shah, Stefan Kommoss, Friedrich Kommoss, C Blake Gilks, Duncan M Baird, David G Huntsman
The telomerase reverse transcriptase (TERT) gene is highly expressed in stem cells and silenced upon differentiation. Cancer cells can attain immortality by activating TERT to maintain telomere length and telomerase activity, which is a crucial step of tumorigenesis. Two somatic mutations in the TERT promoter (C228T; C250T) have been identified as gain-of-function mutations that promote transcriptional activation of TERT in multiple cancers, such as melanoma and glioblastoma. A recent study investigating TERT promoter mutations in ovarian carcinomas found C228T and C250T mutations in 15...
February 15, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29440764/sperm-selection-by-thermotaxis-improves-icsi-outcome-in-mice
#13
Serafín Pérez-Cerezales, Ricardo Laguna-Barraza, Alejandro Chacón de Castro, María Jesús Sánchez-Calabuig, Esther Cano-Oliva, Francisco Javier de Castro-Pita, Luis Montoro-Buils, Eva Pericuesta, Raúl Fernández-González, Alfonso Gutiérrez-Adán
The ejaculate is a heterogeneous pool of spermatozoa containing only a small physiologically adequate subpopulation for fertilization. As there is no method to isolate this subpopulation, its specific characteristics are unknown. This is one of the main reasons why we lack effective tools to identify male infertility and for the low efficiency of assisted reproductive technologies. The aim of this study was to improve ICSI outcome by sperm selection through thermotaxis. Here we show that a specific subpopulation of mouse and human spermatozoa can be selected in vitro by thermotaxis and that this subpopulation is the one that enters the fallopian tube in mice...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29417399/melanoma-brain-metastases-local-therapies-targeted-therapies-immune-checkpoint-inhibitors-and-their-combinations-chances-and-challenges
#14
REVIEW
Marvin Kuske, Ricarda Rauschenberg, Marlene Garzarolli, Michelle Meredyth-Stewart, Stefan Beissert, Esther G C Troost, Oliva Isabella Claudia Glitza, Friedegund Meier
Recent phase II trials have shown that BRAF/MEK inhibitors and immune checkpoint inhibitors are active in patients with melanoma brain metastases (MBM), reporting intracranial disease control rates of 50-75%. Furthermore, retrospective analyses suggest that combining stereotactic radiosurgery with immune checkpoint inhibitors or BRAF/MEK inhibitors prolongs overall survival. These data stress the need for inter- and multidisciplinary cooperation that takes into account the individual prognostic factors in order to establish the best treatment for each patient...
February 7, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29275930/ovarian-sex-cord-stromal-tumours-an-update-in-recent-molecular-advances
#15
REVIEW
Diana Lim, Esther Oliva
Sex cord-stromal tumours (SCSTs) consist of a heterogeneous group of neoplasms with diverse clinicopathological features and biological behaviour. They often present as a diagnostic challenge as they have varied and occasionally overlapping histomorphology and some may even mimic non-SCSTs. An accurate diagnosis is important for therapeutic and prognostic purposes. The use of a panel of immunohistochemical markers which are sensitive and specific for sex cord-stromal differentiation such as α-inhibin, calretinin, SF-1 and FOXL2, may be helpful in confirming the cellular lineage of these tumours, but is of limited utility in distinguishing between the different tumour types within this category...
February 2018: Pathology
https://www.readbyqxmd.com/read/29258703/gynaecological-pathology-problematic-areas-new-concepts-and-emerging-developments
#16
EDITORIAL
W Glenn McCluggage, Esther Oliva
No abstract text is available yet for this article.
February 2018: Pathology
https://www.readbyqxmd.com/read/29192652/zc3h7b-bcor-high-grade-endometrial-stromal-sarcomas-a-report-of-17-cases-of-a-newly-defined-entity
#17
Natasha Lewis, Robert A Soslow, Deborah F Delair, Kay J Park, Rajmohan Murali, Travis J Hollmann, Ben Davidson, Francesca Micci, Ioannis Panagopoulos, Lien N Hoang, Javier A Arias-Stella, Esther Oliva, Robert H Young, Martee L Hensley, Mario M Leitao, Meera Hameed, Ryma Benayed, Marc Ladanyi, Denise Frosina, Achim A Jungbluth, Cristina R Antonescu, Sarah Chiang
High-grade endometrial stromal sarcoma likely encompasses underrecognized tumors harboring genetic abnormalities besides YWHAE-NUTM2 fusion. Triggered by three initial endometrial stromal sarcomas with ZC3H7B-BCOR fusion characterized by high-grade morphology and aggressive clinical behavior, we herein investigate the clinicopathologic features of this genetic subset by expanding the analysis to 17 such tumors. All of them occurred in adult women with a median age of 54 (range, 28-71) years. They were predominantly based in the endomyometrium and demonstrated tongue-like and/or pushing myometrial invasion...
April 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29137233/outcome-of-patients-treated-for-myelodysplastic-syndromes-with-5q-deletion-after-failure-of-lenalidomide-therapy
#18
Thomas Prebet, Thomas Cluzeau, Sophie Park, Mikkael A Sekeres, Ulrich Germing, Lionel Ades, Uwe Platzbecker, Katharina Gotze, Norbert Vey, Esther Oliva, Mary M Sugrue, Cecile Bally, Charikleia Kelaidi, Najla Al Ali, Pierre Fenaux, Steven D Gore, Rami Komrokji
While lenalidomide (LEN) is the standard of care for the lower-risk myelodysplastic syndromes (MDS) patients with deletion 5q, 35% will not respond to or do not tolerate the drug. Moreover, most of the patients will lose their response after a few years. Defining the outcome of patients with LEN failure and determining the impact of subsequent therapies is therefore important to develop alternative strategies. Based on an international collaboration, we were able to compile a total of 392 patient cases of lower-risk MDS patients with 5q deletion and to analyze their outcome after failure of lenalidomide...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29135516/international-endocervical-adenocarcinoma-criteria-and-classification-iecc-a-new-pathogenetic-classification-for-invasive-adenocarcinomas-of-the-endocervix
#19
Simona Stolnicu, Iulia Barsan, Lien Hoang, Prusha Patel, Cristina Terinte, Anna Pesci, Sarit Aviel-Ronen, Takako Kiyokawa, Isabel Alvarado-Cabrero, Malcolm C Pike, Esther Oliva, Kay J Park, Robert A Soslow
We sought to classify endocervical adenocarcinomas (ECAs) based on morphologic features linked to etiology (ie, human papillomavirus [HPV] infection), unlike the World Health Organization 2014 classification. The International Endocervical Adenocarcinoma Criteria and Classification (IECC criteria), described herein, distinguishes between human papillomavirus-associated adenocarcinoma (HPVA), recognized by the presence of luminal mitoses and apoptosis seen at scanning magnification, and no or limited HPVA features (nonhuman papillomavirus-associated adenocarcinoma [NHPVA])...
February 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29094403/longitudinal-changes-in-lic-and-other-parameters-in-patients-receiving-different-chelation-regimens-data-from-licnet
#20
Angela Vitrano, Massimiliano Sacco, Rosamaria Rosso, Alessandra Quota, Daniela Fiorino, Esther Oliva, Calogera Gerardi, Gaetano Roccamo, Vincenzo Spadola, Aldo Filosa, Lorenzo Tesé, Giuseppina Calvaruso, Lorella Pitrolo, Laura Mistretta, Filippo Cassarà, Rosario Di Maggio, Aurelio Maggio
OBJECTIVES: The liver remains the primary site of iron storage, with liver iron concentration (LIC) being a strong surrogate of total body iron. MRI-R2 can accurately measure LIC. The LICNET (Liver Iron Cutino Network) was established to diagnostics of liver iron overload by MRI-R2 subjects with hemochromatosis in hematological disorders. The aims of the study were to look at variation in LIC measurements during time across different chelation regimens. METHODS: This was a cross-sectional study of 130 patients attending 9 Italian centers participating in the LICNET...
February 2018: European Journal of Haematology
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