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Robert kurman

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https://www.readbyqxmd.com/read/27836204/a-nationwide-study-of-ovarian-serous-borderline-tumors-in-denmark-1978-2002-risk-of-recurrence-and-development-of-ovarian-serous-carcinoma
#1
Charlotte Gerd Hannibal, Russell Vang, Jette Junge, Kirsten Frederiksen, Robert J Kurman, Susanne K Kjaer
OBJECTIVE: Absolute risk and risk factors for recurrence and ovarian serous carcinoma following ovarian serous borderline tumors (SBTs) is not well-established. METHODS: We included all women with SBTs in Denmark, 1978-2002. Diagnoses were confirmed by centralized pathology review and classified as atypical proliferative serous tumor (APST) or noninvasive low-grade serous carcinoma (LGSC). Implants were classified as noninvasive or invasive. Medical records were collected and reviewed, and follow-up was obtained...
November 8, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27443516/ccne1-amplification-and-centrosome-number-abnormality-in-serous-tubal-intraepithelial-carcinoma-further-evidence-supporting-its-role-as-a-precursor-of-ovarian-high-grade-serous-carcinoma
#2
Elisabetta Kuhn, Tian-Li Wang, Kai Doberstein, Asli Bahadirli-Talbott, Ayse Ayhan, Ann Smith Sehdev, Ronny Drapkin, Robert J Kurman, Ie-Ming Shih
Aberration in chromosomal structure characterizes almost all cancers and has profound biological significance in tumor development. It can be facilitated by various mechanisms including overexpression of cyclin E1 and centrosome amplification. As ovarian high-grade serous carcinoma has pronounced chromosomal instability, in this study we sought to determine whether increased copy number of CCNE1 which encodes cyclin E1 and centrosome amplification (>2 copies) occurs in its putative precursor, serous tubal intraepithelial carcinoma...
October 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27421040/diagnostic-potential-of-tumor-dna-from-ovarian-cyst-fluid
#3
Yuxuan Wang, Karin Sundfeldt, Constantina Mateoiu, Ie-Ming Shih, Robert J Kurman, Joy Schaefer, Natalie Silliman, Isaac Kinde, Simeon Springer, Michael Foote, Björg Kristjansdottir, Nathan James, Kenneth W Kinzler, Nickolas Papadopoulos, Luis A Diaz, Bert Vogelstein
We determined whether the mutations found in ovarian cancers could be identified in the patients' ovarian cyst fluids. Tumor-specific mutations were detectable in the cyst fluids of 19 of 23 (83%) borderline tumors, 10 of 13 (77%) type I cancers, and 18 of 18 (100%) type II cancers. In contrast, no mutations were found in the cyst fluids of 18 patients with benign tumors or non-neoplastic cysts. Though large, prospective studies are needed to demonstrate the safety and clinical utility of this approach, our results suggest that the genetic evaluation of cyst fluids might be able to inform the management of the large number of women with these lesions...
2016: ELife
https://www.readbyqxmd.com/read/27362903/pd-l1-expression-in-human-placentas-and-gestational-trophoblastic-diseases
#4
Emanuela Veras, Robert J Kurman, Tian-Li Wang, Ie-Ming Shih
One of the major immune checkpoints responsible for immune evasion in cancer cells is the interaction between programmed cell death-1 (PD-1) and its ligand (PD-L1). As human trophoblastic cells display many of the features of malignant cells such as the ability to invade normal tissue including blood vessels and are apparently not eradicated by the host immune system, we undertook the present study to determine whether PD-L1 was upregulated in different types of trophoblastic cells during normal pregnancy and in gestational trophoblastic diseases...
June 29, 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/27012190/the-dualistic-model-of-ovarian-carcinogenesis-revisited-revised-and-expanded
#5
REVIEW
Robert J Kurman, Ie-Ming Shih
Since our proposal of a dualistic model of epithelial ovarian carcinogenesis more than a decade ago, a large number of molecular and histopathologic studies were published that have provided important insights into the origin and molecular pathogenesis of this disease. This has required that the original model be revised and expanded to incorporate these findings. The new model divides type I tumors into three groups: i) endometriosis-related tumors that include endometrioid, clear cell, and seromucinous carcinomas; ii) low-grade serous carcinomas; and iii) mucinous carcinomas and malignant Brenner tumors...
April 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/26894303/the-new-who-classification-of-ovarian-fallopian-tube-and-primary-peritoneal-cancer-and-its-clinical-implications
#6
Ivo Meinhold-Heerlein, Christina Fotopoulou, Philipp Harter, Christian Kurzeder, Alexander Mustea, Pauline Wimberger, Steffen Hauptmann, Jalid Sehouli
INTRODUCTION: Molecular pathological research has contributed to improving the knowledge of different subtypes of ovarian cancer. In parallel with the implementation of the new FIGO staging classification, the WHO classification was revised. The latter is mainly based on the histopathological findings and defines the actual type of tumor. It has, therefore, also an important impact on prognosis and therapy of the patient. MATERIALS AND METHODS: The new WHO Classification of Ovarian Cancer published 2014 by Robert Kurman and co-authors is summarized...
April 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/26598986/seromucinous-tumors-of-the-ovary-what-s-in-a-name
#7
Robert J Kurman, Ie-Ming Shih
The recent 2014 World Health Organization (WHO) Classification of Tumours of the Female Reproductive Organs introduced a new category of ovarian neoplasm designated "seromucinous tumours". The recognition of this distinctive group of tumors is an important addition to the classification but the term "seromucinous" has serious flaws that obscures the nature of these neoplasms. Morphologically, seromucinous tumors in addition to serous and endocervical-type mucinous epithelium, contain endometrioid, indifferent and squamous type epithelium...
January 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/26355245/molecular-analysis-of-ovarian-mucinous-carcinoma-reveals-different-cell-of-origins
#8
Yihong Wang, Lauren Ende Shwartz, Derek Anderson, Ming-Tseh Lin, Lisa Haley, Ren-Chin Wu, Russell Vang, Ie-Ming Shih, Robert J Kurman
It is believed that a subset of primary ovarian mucinous tumors is derived from mature teratomas [1-5]. To confirm this, we performed microsatellite genotyping using a variety of short tandem repeat makers and analyzed allelotypes of 8 mucinous tumors (4 mucinous carcinomas, 3 atypical proliferative mucinous tumors and 1 mucinous cystadenoma) associated with a teratoma to determine whether they were clonally related. 7 of the 8 mucinous tumors showed complete or a high degree of homozygosity. Among the 6 pairs of tumors with teratoma tissue available for comparison, 5 of 6 showed a high or complete degree of allelotypes matching, which differed from the somatic allelotypes of the normal control tissue...
September 8, 2015: Oncotarget
https://www.readbyqxmd.com/read/26166714/molecular-alterations-of-tp53-are-a-defining-feature-of-ovarian-high-grade-serous-carcinoma-a-rereview-of-cases-lacking-tp53-mutations-in-the-cancer-genome-atlas-ovarian-study
#9
Russell Vang, Douglas A Levine, Robert A Soslow, Charles Zaloudek, Ie-Ming Shih, Robert J Kurman
The Cancer Genome Atlas has reported that 96% of ovarian high-grade serous carcinomas (HGSCs) have TP53 somatic mutations suggesting that mutation of this gene is a defining feature of this neoplasm. In the current study, 5 gynecologic pathologists independently evaluated hematoxylin and eosin slides of 14 available cases from The Cancer Genome Atlas classified as HGSC that lacked a TP53 mutation. The histologic diagnoses rendered by these pathologists and the accompanying molecular genetic data are the subject of this report...
January 2016: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/26095692/clonality-analysis-of-combined-brenner-and-mucinous-tumours-of-the-ovary-reveals-their-monoclonal-origin
#10
Yihong Wang, Ren-chin Wu, Lauren Ende Shwartz, Lisa Haley, Ming-tse Lin, Ie-ming Shih, Robert J Kurman
The derivation of ovarian intestinal-type mucinous tumours is not well established. Some are derived from teratomas but the origin of the majority is not clear. It has been recently proposed that the non-germ cell group may be derived from Brenner tumours, as the association of a mucinous tumour with a Brenner tumour is frequently observed. In order to explore the histogenesis of these neoplasms, we undertook a clonality analysis of the two components of ten combined Brenner and mucinous tumours using a human androgen receptor gene (HUMARA) assay...
October 2015: Journal of Pathology
https://www.readbyqxmd.com/read/25473746/two-types-of-ovarian-cortical-inclusion-cysts-proposed-origin-and-possible-role-in-ovarian-serous-carcinogenesis
#11
COMPARATIVE STUDY
Natalie Banet, Robert J Kurman
Ovarian cortical inclusion cysts (CICs) have been long regarded as a possible site of origin of epithelial ovarian carcinoma. It has been proposed that they develop from invagination of ovarian surface epithelium (OSE) which then undergoes metaplasia to form mullerian-type tissue and then undergoes neoplastic transformation. Recent studies have challenged this view, at least for high-grade serous carcinoma, proposing that the latter arise from occult carcinomas in the fallopian tube. Although there is compelling evidence supporting this view, it does not account for the origin of all high-grade serous carcinomas...
January 2015: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/25272297/characterization-of-the-immune-cell-repertoire-in-the-normal-fallopian-tube
#12
Laura Ardighieri, Silvia Lonardi, Daniele Moratto, Fabio Facchetti, Ie-Ming Shih, William Vermi, Robert J Kurman
Recent studies implicating the fallopian tube as the site of putative precursors of ovarian serous carcinoma, and the hypothesis that injury, inflammation, and repair of the ovarian surface epithelium at the time of ovulation, may be contributing factors to ovarian carcinogenesis, prompted us to undertake a comprehensive analysis of the immune cells in the normal fallopian tube. Accordingly, the aim of this study was to provide a baseline for future studies exploring the relationship of inflammation with the early events of ovarian carcinogenesis by characterizing the immune cell repertoire in 13 normal human fallopian tubes, combining digital microscopy of immunostained slides and flow cytometry of fresh single-cell suspensions, with a panel of markers that identify the most important adaptive and innate immune cells...
November 2014: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/25216223/loss-of-aldh1a1-expression-is-an-early-event-in-the-pathogenesis-of-ovarian-high-grade-serous-carcinoma
#13
M Herman Chui, Yihong Wang, Ren-Chin Wu, Jeffrey Seidman, Robert J Kurman, Tian-Li Wang, Ie-Ming Shih
Tumor-initiating cells are thought to share features with normal somatic stem cells. In mice, stem cells at the ovarian hilum have been shown to express the stem cell marker, aldehyde dehydrogenase isoform 1A1 (ALDH1A1), and are prone to malignant transformation. The potential relevance of this finding to humans has not been established. In this study, we used immunohistochemistry to assess the distribution of ALDH1A1 staining in the epithelium of human fallopian tubes, with particular reference to the transition of tubal epithelium to mesothelium (ie, tubal-mesothelial junction), ovarian surface epithelium, as well as putative precursors of ovarian high-grade serous carcinoma, namely, serous tubal intraepithelial carcinoma and 'p53 signatures,' and overt serous carcinoma...
March 2015: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/25188864/braf-mutation-is-associated-with-a-specific-cell-type-with-features-suggestive-of-senescence-in-ovarian-serous-borderline-atypical-proliferative-tumors
#14
Felix Zeppernick, Laura Ardighieri, Charlotte G Hannibal, Russell Vang, Jette Junge, Susanne K Kjaer, Rugang Zhang, Robert J Kurman, Ie-Ming Shih
Serous borderline tumor also known as atypical proliferative serous tumor (APST) is the precursor of ovarian low-grade serous carcinoma (LGSC). In this study, we correlated the morphologic and immunohistochemical phenotypes of 71 APSTs and 18 LGSCs with the mutational status of KRAS and BRAF, the most common molecular genetic changes in these neoplasms. A subset of cells characterized by abundant eosinophilic cytoplasm (EC), discrete cell borders, and bland nuclei was identified in all (100%) 25 BRAF-mutated APSTs but in only 5 (10%) of 46 APSTs without BRAF mutations (P<0...
December 2014: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/24924123/a-nationwide-study-of-serous-borderline-ovarian-tumors-in-denmark-1978-2002-centralized-pathology-review-and-overall-survival-compared-with-the-general-population
#15
COMPARATIVE STUDY
Charlotte Gerd Hannibal, Russell Vang, Jette Junge, Kirsten Frederiksen, Anette Kjaerbye-Thygesen, Klaus Kaae Andersen, Ann Tabor, Robert J Kurman, Susanne K Kjaer
OBJECTIVE: To describe the study population and estimate overall survival of women with a serous "borderline" ovarian tumor (SBT) in Denmark over 25 years relative to the general population. METHODS: The Danish Pathology Data Bank and the Danish Cancer Registry were used to identify 1487 women diagnosed with SBTs from 1978 to 2002. The histologic slides were collected from Danish pathology departments and reviewed by expert pathologists and classified as SBT/atypical proliferative serous tumor (APST) or noninvasive low-grade serous carcinoma (LGSC)...
August 2014: Gynecologic Oncology
https://www.readbyqxmd.com/read/24901393/discovery-of-a-cell-reflections-on-the-checkered-history-of-intermediate-trophoblast-and-update-on-its-nature-and-pathologic-manifestations
#16
Robert J Kurman, Ie-Ming Shih
In 1976, a series of 12 cases describing a lesion that had previously not been well characterized was reported as "trophoblastic pseudotumor of the uterus." Up until that time rare reports of the lesion had classified it most often as an unusual type of sarcoma associated with pregnancy. All patients in that series were alive and well except for one who died from complications of a uterine perforation occurring at the time of a diagnostic curettage. Thus, it appeared to be a benign neoplasm but subsequently it was found that some exhibited malignant behavior and the tumor was renamed "placental site trophoblastic tumor...
July 2014: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/24652535/a-genetically-engineered-ovarian-cancer-mouse-model-based-on-fallopian-tube-transformation-mimics-human-high-grade-serous-carcinoma-development
#17
Cheryl A Sherman-Baust, Elisabetta Kuhn, Blanca L Valle, Ie-Ming Shih, Robert J Kurman, Tian-Li Wang, Tomokazu Amano, Minoru S H Ko, Ichiro Miyoshi, Yoshihiko Araki, Elin Lehrmann, Yongqing Zhang, Kevin G Becker, Patrice J Morin
Recent evidence suggests that ovarian high-grade serous carcinoma (HGSC) originates from the epithelium of the fallopian tube. However, most mouse models are based on the previous prevailing view that ovarian cancer develops from the transformation of the ovarian surface epithelium. Here, we report the extensive histological and molecular characterization of the mogp-TAg transgenic mouse, which expresses the SV40 large T-antigen (TAg) under the control of the mouse müllerian-specific Ovgp-1 promoter. Histological analysis of the fallopian tubes of mogp-TAg mice identified a variety of neoplastic lesions analogous to those described as precursors to ovarian HGSC...
July 2014: Journal of Pathology
https://www.readbyqxmd.com/read/24487464/ki-67-index-as-an-ancillary-tool-in-the-differential-diagnosis-of-proliferative-endometrial-lesions-with-secretory-change
#18
Grzegorz T Gurda, Alexander S Baras, Robert J Kurman
"Secretory change" can accompany a variety of proliferative endometrial lesions, ranging from hyperplasia to carcinoma. It is characterized by subnuclear or supranuclear vacuolization, mimicking early secretory endometrium (SEM). As an additional diagnostic challenge, mitotic activity and cytologic atypia are often low in hyperplastic lesions with secretory change. As mitotic activity in lesions with secretory change is decreased, the mitotic index may not be useful to distinguish SEM with glandular crowding from hyperplasia with secretory change...
March 2014: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/24441661/evaluation-of-microinvasion-and-lymph-node-involvement-in-ovarian-serous-borderline-atypical-proliferative-serous-tumors-a-morphologic-and-immunohistochemical-analysis-of-37-cases
#19
Kruti P Maniar, Yihong Wang, Kala Visvanathan, Ie-Ming Shih, Robert J Kurman
Most of the literature on serous borderline/atypical proliferative serous tumors (SBT/APSTs) shows no effect of microinvasion or lymph node involvement on outcome. This study is a morphologic and immunohistochemical analysis of the cells comprising SBT/APSTs, microinvasion, lymph node involvement, and low-grade serous carcinoma (LGSC) in an attempt to explain this unusual behavior. We found that the cells in microinvasion and in lymph nodes were morphologically similar to the cells in SBT/APSTs but differed significantly from the cells in LGSCs...
June 2014: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/24316307/pathologic-features-associated-with-resolution-of-complex-atypical-hyperplasia-and-grade-1-endometrial-adenocarcinoma-after-progestin-therapy
#20
Camille C Gunderson, Sonia Dutta, Amanda Nickles Fader, Kruti P Maniar, Niloo Nasseri-Nik, Robert E Bristow, Teresa P Diaz-Montes, Robert Palermo, Robert J Kurman
OBJECTIVE: To determine the response of complex atypical hyperplasia (CAH) and well differentiated endometrioid adenocarcinoma of the uterus (WDC) to progestin therapy and whether pre-treatment estrogen and progesterone receptor status predicts outcome. METHODS: We performed a retrospective review encompassing women treated with progestin therapy for CAH or WDC at two institutions. Clinicopathologic, treatment, and recurrence data were recorded. Pre/post-treatment pathologic evaluation was performed...
January 2014: Gynecologic Oncology
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