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JOURNAL ARTICLE
Simona Stolnicu, Aaron M Praiss, Douglas Allison, Basile Tessier-Cloutier, Jessica Flynn, Alexia Iasonos, Lien Hoang, Cristina Terinte, Anna Pesci, Claudia Mateoiu, Ricardo R Lastra, Takako Kiyokawa, Rouba Ali-Fehmi, Mira Kheil, Esther Oliva, Kyle Devins, Nadeem Abu-Rustum, Robert A Soslow
We compared grading systems and examined associations with tumor stroma and survival in patients with cervical squamous cell carcinoma. Available tumor slides were collected from 10 international institutions. Broders tumor grade, Jesinghaus grade (informed by the pattern of tumor invasion), Silva pattern, and tumor stroma were retrospectively analyzed; associations with overall survival (OS), progression-free survival (PFS), and presence of lymph node metastases were examined. Binary grading systems incorporating tumor stromal changes into Broders and Jesinghaus grading systems were developed...
November 9, 2023: International Journal of Gynecological Pathology
#2
JOURNAL ARTICLE
Simona Stolnicu, Andrei Patrichi, Francisc Rozsnyai, Robert A Soslow
We present the case of a 71-year-old patient, with vaginal bleeding, dyspnea, headache, loss of appetite and weakness. Clinical examination revealed a pediculated vaginal mass of 25 mm diameter, of dark-red color and soft spongy consistency, with an ulcerated surface and originating from the anterior wall, which was surgically removed. The morphology was dominanted by large, round to polygonal tumor cells, arranged in a predominantly tubulo-cystic architecture, surrounding numerous blood vessels that dominated the appearance, suggesting a perivascular epithelioid cell tumor (PEComa) or hemangioblastoma but the presence of pleomorphic nuclei, numerous mitoses together with immunohistochemistry helped for a correct diagnosis of vaginal ...
2023: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
#3
JOURNAL ARTICLE
Simona Stolnicu, Douglas Allison, Aaron M Praiss, Basile Tessier-Cloutier, Amir Momeni Boroujeni, Jessica Flynn, Alexia Iasonos, Rene Serrette, Lien Hoang, Andrei Patrichi, Cristina Terinte, Anna Pesci, Claudia Mateoiu, Ricardo R Lastra, Takako Kiyokawa, Rouba Ali-Fehmi, Mira Kheil, Esther Oliva, Kyle M Devins, Nadeem R Abu-Rustum, Robert A Soslow
We aimed to determine the frequency of human papillomavirus-independent (HPVI) cervical squamous cell carcinoma (SCC) and to describe clinicopathologic characteristics. Among 670 patients with surgically treated SCCs in an established multi-institutional cohort, 447 had available tissue. Tissue microarrays were constructed and studied by in situ hybridization (ISH) for high-risk and low-risk human papillomavirus (HPV) mRNA and immunohistochemistry for p16 and p53. Tumors were HPVI if negative by HPV ISH and they failed to show diffuse p16 positivity by immunohistochemistry, and human papillomavirus-associated (HPVA) if positive by HPV ISH...
December 1, 2023: American Journal of Surgical Pathology
#4
REVIEW
Simona Stolnicu, Douglas Allison, Andrei Patrichi, Jessica Flynn, Alexia Iasonos, Robert A Soslow
Cervical cancer is the fourth most common cancer among women globally. Historically, human papillomavirus (HPV) infection was considered necessary for the development of both precursor and invasive epithelial tumors of the cervix; however, studies in the last decade have shown that a significant proportion of cervical carcinomas are HPV-independent (HPVI). The 2020 World Health Organization (WHO) Classification of Female Genital Tumors separates both squamous cell carcinomas (SCCs) and endocervical adenocarcinomas (ECAs) by HPV status into HPV-associated (HPVA) and HPVI tumors...
January 1, 2024: Advances in Anatomic Pathology
#5
JOURNAL ARTICLE
Ian S Hagemann, Wei Deng, Richard J Zaino, Matthew A Powell, Camille Gunderson Jackson, Casey Cosgrove, Cara Mathews, Michael L Pearl, Steven Waggoner, Rahel Ghebre, Shashikant Lele, Saketh Guntupalli, Angeles Alvarez Secord, Olga Ioffe, Golnar Rasty, Meenakshi Singh, Robert Soslow, William Creasman, David G Mutch
OBJECTIVES: Clear cell carcinoma is a high-risk subtype of endometrial cancer. Some patients have a mixture of clear cell carcinoma with other histologic types (endometrioid or serous) or cannot be neatly assigned to one of these types. Protocol GOG-8032 within GOG-210 was designed to determine whether these tumors differ from pure clear cell carcinoma in stage at diagnosis, initial pattern of spread, or patient survival. METHODS: The term "mixed" was applied to tumors with multiple identifiable components, and "indeterminate" was applied to tumors with features intermediate between different histologic types...
October 2023: Gynecologic Oncology
#6
JOURNAL ARTICLE
Aaron M Praiss, Douglas Allison, Basile Tessier-Cloutier, Jessica Flynn, Alexia Iasonos, Lien Hoang, Andrei Patrichi, Cristina Terinte, Anna Pesci, Claudia Mateoiu, Ricardo R Lastra, Lucian Puscasiu, Takako Kiyokawa, Rouba Ali-Fehmi, Mira Kheil, Esther Oliva, Kyle M Devins, Nadeem R Abu-Rustum, Robert A Soslow, Simona Stolnicu
OBJECTIVE: We evaluated clinicopathologic parameters of patients with cervical squamous cell carcinoma (SCC) who were treated with initial surgical management and assessed their relation to survival outcomes. Specifically, we evaluated the relation between extent of lymphovascular invasion (LVI) and survival outcomes. METHODS: All available tumor slides from patients with initially surgically treated cervical SCC were collected from 10 institutions and retrospectively analyzed...
September 2023: Gynecologic Oncology
#7
JOURNAL ARTICLE
A preoperative nomogram incorporating CT to predict the probability of ovarian clear cell carcinoma.
Natally Horvat, Pamela Causa Andrieu, Andreas Meier, Xinge Ji, Yulia Lakhman, Robert Soslow, Douglas Allison, Natalie Gangai, Lee Rodriguez, Michael W Kattan, Dennis S Chi, Hedvig Hricak
OBJECTIVES: To evaluate clinical, laboratory, and radiological variables from preoperative contrast-enhanced computed tomography (CECT) for their ability to distinguish ovarian clear cell carcinoma (OCCC) from non-OCCC and to develop a nomogram to preoperatively predict the probability of OCCC. METHODS: This IRB-approved, retrospective study included consecutive patients who underwent surgery for an ovarian tumor from 1/1/2000 to 12/31/2016 and CECT of the abdomen and pelvis ≤90 days before primary debulking surgery...
July 19, 2023: Gynecologic Oncology
#8
JOURNAL ARTICLE
Roisin E O'Cearbhaill, Austin Miller, Robert A Soslow, Heather A Lankes, Deborah DeLair, Sheila Segura, Shweta Chavan, Dmitriy Zamarin, Robert DeBernardo, Kathleen Moore, John Moroney, Mark Shahin, Premal H Thaker, Andrea E Wahner-Hendrickson, Carol Aghajanian
OBJECTIVE: Gynecologic cancers are traditionally managed according to their presumed site of origin, without regard to the underlying histologic subtype. Clear cell histology is associated with chemotherapy refractoriness and poor survival. Mutations in SWI/SNF chromatin remodeling complex member ARID1A, which encodes for BAF250a protein, are common in clear cell and endometriosis-associated endometrioid carcinomas. High-throughput cell-based drug screening predicted activity of dasatinib, a tyrosine kinase inhibitor, in ARID1A-mutant clear cell carcinoma...
September 2023: Gynecologic Oncology
#9
JOURNAL ARTICLE
Elizabeth Kertowidjojo, Amir Momeni-Boroujeni, Eric Rios-Doria, Nadeem Abu-Rustum, Robert A Soslow
With the advancement of diagnostic molecular technology and the molecular classification of endometrial endometrioid carcinoma (EEC), it remains to be seen whether conventional International Federation of Gynecology and Obstetrics (FIGO) grading retains clinical significance in certain molecular subtypes of EECs. In this study, we explored the clinical significance of FIGO grading in microsatellite instability-high (MSI-H) and POLE-mutant EECs. A total of 162 cases of MSI-H EECs and 50 cases of POLE-mutant EECs were included in the analysis...
September 2023: Modern Pathology
#10
JOURNAL ARTICLE
Tiffany Y Sia, Derman Basaran, Christian Dagher, Dib Sassine, Benny Brandt, Kendall Rosalik, Jennifer J Mueller, Vance Broach, Vicky Makker, Robert A Soslow, Nadeem R Abu-Rustum, Mario M Leitao
OBJECTIVES: We sought to compare outcomes between minimally invasive surgery (MIS) and laparotomy in patients with clinical stage I uterine serous carcinoma (USC). METHODS: Patients who underwent surgery for newly diagnosed USC between 11/1/1993 and 12/31/2017 were retrospectively identified and assigned to either the MIS cohort or the laparotomy cohort. Patients with conversion to laparotomy were analyzed with the MIS cohort. Chi-square and Mann-Whitney tests were used to compare categorical and continuous variables, respectively...
May 31, 2023: Gynecologic Oncology
#11
JOURNAL ARTICLE
Amir Momeni-Boroujeni, Chad Vanderbilt, Elham Yousefi, Nadeem R Abu-Rustum, Carol Aghajanian, Robert A Soslow, Lora H Ellenson, Britta Weigelt, Rajmohan Murali
OBJECTIVE: Chromatin remodeling genes (CRGs) encode components of epigenetic regulatory mechanisms and alterations in these genes have been identified in several tumor types, including gynecologic cancers. In this study, we sought to investigate the prevalence and clinicopathological associations of CRG alterations in endometrial carcinoma (EC). METHODS: We performed a retrospective analysis of 660 ECs sequenced using a clinical massively parallel sequencing assay targeting up to 468 genes, including 25 CRGs, and defined the presence of somatic CRG alterations...
March 20, 2023: Gynecologic Oncology
#12
JOURNAL ARTICLE
M Herman Chui, Rajmohan Murali, Robert A Soslow, Cathleen Matrai, Deyin Xing, Russell Vang
Ovarian serous borderline tumors (SBTs) harboring the BRAFV600E mutation are associated with decreased risk of progression to low-grade serous carcinoma, and often prominently feature tumor cells with abundant eosinophilic cytoplasm. Since eosinophilic cells (ECs) may be a marker of the underlying genetic driver, we proposed morphologic criteria and evaluated the interobserver reproducibility for assessing this histologic feature. Following the completion of an online training module, representative tumor slides from 40 SBTs (BRAFV600E-mutated, n=18, BRAF-wildtype, n=22) were independently reviewed by 5 pathologists...
January 23, 2023: International Journal of Gynecological Pathology
#13
COMMENT
Seyram A Doe-Tetteh, Sabrina Y Camp, Dalicia Reales, Jett Crowdis, Anne Marie Noronha, Bernadette Wolff, Tina Alano, Jesse Galle, S Duygu Selcuklu, Agnes Viale, Nicholas D Socci, Ying L Liu, William P Tew, Carol Aghajanian, Marc Ladanyi, Meng Xiao He, Saud H AlDubayan, Roei David Mazor, Ofer Shpilberg, Oshrat Hershkovitz-Rokah, Jose A Riancho, Jose L Hernandez, M Carmen Gonzalez-Vela, Justin J Buthorn, Manda Wilson, Amy E Webber, Mariko Yabe, Kseniya Petrova-Drus, Marc Rosenblum, Benjamin H Durham, Omar Abdel-Wahab, Michael F Berger, Mark T A Donoghue, Andrew L Kung, Julia Glade Bender, Neerav N Shukla, Samuel A Funt, Ahmet Dogan, Robert A Soslow, Hikmat Al-Ahmadie, Darren R Feldman, Eliezer M Van Allen, Eli L Diamond, David B Solit
PURPOSE: To overcome barriers to genomic testing for patients with rare cancers, we initiated a program to offer free clinical tumor genomic testing worldwide to patients with select rare cancer subtypes. EXPERIMENTAL DESIGN: Patients were recruited through social media outreach and engagement with disease-specific advocacy groups, with a focus on patients with histiocytosis, germ cell tumors (GCT), and pediatric cancers. Tumors were analyzed using the MSK-IMPACT next-generation sequencing assay with the return of results to patients and their local physicians...
July 5, 2023: Clinical Cancer Research
#14
JOURNAL ARTICLE
Simona Stolnicu, Rolland-Jozsef Bartalis, Qiqi Ye, Arnaud Da Cruz Paula, Britta Weigelt, Robert A Soslow
Gynecologic carcinomas with RAS mutations may show a wide spectrum of histologic types, including mixed types. We present the case of a 63-yr-old patient diagnosed with an ovarian tumor harboring a mesonephric-like adenocarcinoma in a background of mixed mesonephric-like, mucinous, and endometrioid components. Molecular analysis revealed that all 3 components shared the same clonal KRAS mutation (p.G12A) and chromosome 1q gain. Based on shifts in clonality, copy number gains, and acquisition of an additional mutation, our data suggest that the mucinous component likely constituted the substrate from which the mesonephric-like and endometrioid components arose...
January 9, 2023: International Journal of Gynecological Pathology
#15
JOURNAL ARTICLE
Ignacio Vázquez-García, Florian Uhlitz, Nicholas Ceglia, Jamie L P Lim, Michelle Wu, Neeman Mohibullah, Juliana Niyazov, Arvin Eric B Ruiz, Kevin M Boehm, Viktoria Bojilova, Christopher J Fong, Tyler Funnell, Diljot Grewal, Eliyahu Havasov, Samantha Leung, Arfath Pasha, Druv M Patel, Maryam Pourmaleki, Nicole Rusk, Hongyu Shi, Rami Vanguri, Marc J Williams, Allen W Zhang, Vance Broach, Dennis S Chi, Arnaud Da Cruz Paula, Ginger J Gardner, Sarah H Kim, Matthew Lennon, Kara Long Roche, Yukio Sonoda, Oliver Zivanovic, Ritika Kundra, Agnes Viale, Fatemeh N Derakhshan, Luke Geneslaw, Shirin Issa Bhaloo, Ana Maroldi, Rahelly Nunez, Fresia Pareja, Anthe Stylianou, Mahsa Vahdatinia, Yonina Bykov, Rachel N Grisham, Ying L Liu, Yulia Lakhman, Ines Nikolovski, Daniel Kelly, Jianjiong Gao, Andrea Schietinger, Travis J Hollmann, Samuel F Bakhoum, Robert A Soslow, Lora H Ellenson, Nadeem R Abu-Rustum, Carol Aghajanian, Claire F Friedman, Andrew McPherson, Britta Weigelt, Dmitriy Zamarin, Sohrab P Shah
High-grade serous ovarian cancer (HGSOC) is an archetypal cancer of genomic instability1-4 patterned by distinct mutational processes5,6 , tumour heterogeneity7-9 and intraperitoneal spread7,8,10 . Immunotherapies have had limited efficacy in HGSOC11-13 , highlighting an unmet need to assess how mutational processes and the anatomical sites of tumour foci determine the immunological states of the tumour microenvironment. Here we carried out an integrative analysis of whole-genome sequencing, single-cell RNA sequencing, digital histopathology and multiplexed immunofluorescence of 160 tumour sites from 42 treatment-naive patients with HGSOC...
December 2022: Nature
#16
JOURNAL ARTICLE
Simona Stolnicu, Maria J Brito, Georgia Karpathiou, Lynn Hoang, Ana Felix, Claudia Mateoiu, Daniela Fanni, Armando Reques, Angel Garcia, David Hardisson, Canan K Talu, Antonia Furtado, Nadeem Abu-Rustum, Robert A Soslow, Kay J Park
Villoglandular adenocarcinoma of the cervix is a rare histologic entity that typically develops in young women, characterized by an association with oral contraceptives and excellent prognosis, though this point is controversial. These tumors have not been studied in the context of the International Endocervical Adenocarcinoma Criteria and Classification (IECC) or Silva Pattern Classification. We analyzed 31 cases that met strict diagnostic criteria, including being completely excised with negative margins...
November 15, 2022: International Journal of Gynecological Pathology
#17
JOURNAL ARTICLE
Xavier Matias-Guiu, Christina I Selinger, Lyndal Anderson, Natalia Buza, Lora H Ellenson, Oluwole Fadare, Raji Ganesan, Philip P C Ip, Jose Palacios, Carlos Parra-Herran, Maria R Raspollini, Robert A Soslow, Henrica M J Werner, Sigurd F Lax, W Glenn McCluggage
Endometrial cancer is one of the most common cancers among women. The International Collaboration on Cancer Reporting (ICCR) developed a standardized endometrial cancer data set in 2011, which provided detailed recommendations for the reporting of resection specimens of these neoplasms. A new data set has been developed, which incorporates the updated 2020 World Health Organization Classification of Female Genital Tumors, the Cancer Genome Atlas (TCGA) molecular classification of endometrial cancers, and other major advances in endometrial cancer reporting, all of which necessitated a major revision of the data set...
November 1, 2022: International Journal of Gynecological Pathology
#18
JOURNAL ARTICLE
Marisa R Nucci, Fleur Webster, Sabrina Croce, Suzanne George, Brooke E Howitt, Philip P C Ip, Cheng-Han Lee, Joseph T Rabban, Robert A Soslow, Rachael van der Griend, Sigurd F Lax, W Glenn McCluggage
The International Collaboration on Cancer Reporting (ICCR) seeks to produce standardized, evidence-based protocols for the reporting of tumors with the aim of ensuring that all cancer reports generated worldwide will be of similar high quality and record the same elements. Herein, we describe the development of the data set for the reporting of uterine malignant and potentially malignant mesenchymal tumors by a panel of expert pathologists and a single clinician and provide the commentary and rationale for the inclusion of core and noncore elements...
November 1, 2022: International Journal of Gynecological Pathology
#19
JOURNAL ARTICLE
Simona Stolnicu, Rolland-Jozsef Bartalis, Emilia Mihut, Bela Szabo, Arnaud Da Cruz Paula, Qiqi Ye, Vinita Parkash, Britta Weigelt, Robert A Soslow
We describe a very unusual cervical tumor in a 12-yr-old patient with a clinical history indicative of DICER1 syndrome. Morphologic, immunohistochemical, and molecular genetic analysis together helped to diagnose this lesion as a cervical pleuropulmonary blastoma-like tumor, associated with TP53 and DICER1 mutations. The tumor displayed usual histologic features including mixtures of embryonal rhabdomyosarcoma, sarcomatous cartilage, compact blastema, primitive spindle cells and anaplasia, akin to type III pleuropulmonary blastoma, and trabecular and retiform patterns...
October 20, 2022: International Journal of Gynecological Pathology
#20
JOURNAL ARTICLE
Amir Momeni Boroujeni, Elizabeth Kertowidjojo, Xinyu Wu, Robert A Soslow, Sarah Chiang, Edaise M Da Silva, Britta Weigelt, M Herman Chui
Mullerian adenosarcoma is an uncommon mesenchymal tumor of the gynecologic tract. Most cases are low-grade, while high-grade adenosarcomas are rare and not well studied. Herein, we characterize the clinicopathologic and molecular features of 27 adenosarcomas of gynecologic origin, enriched for high-grade tumors subjected to targeted panel sequencing. Sarcomatous overgrowth was more frequently seen in high-grade compared to low-grade tumors (12/17, 71%, vs 1/10, 10%, p = 0.004) and heterologous elements were exclusive to high-grade cases (n = 7, p = 0...
November 2022: Modern Pathology
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