keyword
MENU ▼
Read by QxMD icon Read
search

Jaime prat

keyword
https://www.readbyqxmd.com/read/27895324/molecular-genetic-heterogeneity-in-undifferentiated-endometrial-carcinomas
#1
Juan M Rosa-Rosa, Susanna Leskelä, Eva Cristóbal-Lana, Almudena Santón, Ma Ángeles López-García, Gloria Muñoz, Belen Pérez-Mies, Michele Biscuola, Jaime Prat, Oliva E Esther, Robert A Soslow, Xavier Matias-Guiu, Jose Palacios
No abstract text is available yet for this article.
December 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27491810/molecular-genetic-heterogeneity-in-undifferentiated-endometrial-carcinomas
#2
Juan M Rosa-Rosa, Susanna Leskelä, Eva Cristóbal-Lana, Almudena Santón, Ma Ángeles López-García, Gloria Muñoz, Belen Pérez-Mies, Michele Biscuola, Jaime Prat, Oliva E Esther, Robert A Soslow, Xavier Matias-Guiu, Jose Palacios
Undifferentiated and dedifferentiated endometrial carcinomas are rare and highly aggressive subtypes of uterine cancer, not well characterized at a molecular level. To investigate whether dedifferentiated carcinomas carry molecular genetic alterations similar to those of pure undifferentiated carcinomas, and to gain insight into the pathogenesis of these tumors, we selected a cohort of 18 undifferentiated endometrial carcinomas, 8 of them with a well-differentiated endometrioid carcinoma component (dedifferentiated endometrioid carcinomas), and studied them by immunohistochemistry and massive parallel and Sanger sequencing...
August 5, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27346574/cd8-down-regulation-on-cytotoxic-t-lymphocytes-of-patients-with-endometrioid-endometrial-carcinomas
#3
Mónica Pascual-García, Cristina Bértolo, Juan C Nieto, Neus Serrat, Íñigo Espinosa, Emanuela D'Angelo, Raquel Muñoz, Ramón Rovira, Silvia Vidal, Jaime Prat
Carcinogenesis is a multistep process in which cancer cells and tumor stroma cells play important roles. T lymphocytes are immune constituents of tumor stroma and play a crucial function in anti-tumor response. By immunohistochemistry and flow cytometry, we studied T cytotoxic (CTLs) and T helper lymphocyte distribution and percentage in the tumor microenvironment and peripheral blood from 35 patients with endometrioid endometrial carcinomas (EEC). We also studied 23 healthy donors' blood samples as a control group...
October 2016: Human Pathology
https://www.readbyqxmd.com/read/26975040/mixed-and-ambiguous-endometrial-carcinomas-a-heterogenous-group-of-tumors-with-different-clinicopathologic-and-molecular-genetic-features
#4
Iñigo Espinosa, Emanuela D'Angelo, José Palacios, Jaime Prat
Besides endometrioid, serous, and clear cell carcinomas, there are endometrial carcinomas exhibiting mixed and ambiguous morphologic features. We have analyzed the immunophenotype (p53, p16, β-catenin, ER, HNF-1B, MLH1, and Ki-67) and mutational status (PTEN, KRAS, PIK3CA, and POLE) of 7 mixed carcinomas and 13 ambiguous carcinomas, all of them classified initially as mixed carcinomas. Only 2 of the 7 (28%) mixed carcinomas showed different immunophenotypes in different components. All but 2 tumors (5/7, 71%) overexpressed p53 and p16 and were negative for ER...
July 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/26961430/-in-memoriam-jaime-campos-castello-1940-2015
#5
José M Prats-Viñas
No abstract text is available yet for this article.
March 16, 2016: Revista de Neurologia
https://www.readbyqxmd.com/read/26433670/pathology-of-cancers-of-the-female-genital-tract
#6
Jaime Prat
No abstract text is available yet for this article.
October 2015: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/26433669/the-future-role-of-molecular-staging-in-gynecologic-cancer
#7
Pratibha S Binder, Jaime Prat, David G Mutch
No abstract text is available yet for this article.
October 2015: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/26433666/uterine-sarcomas
#8
Jaime Prat, 'Nomonde Mbatani
No abstract text is available yet for this article.
October 2015: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/26362254/molecular-analyses-of-juvenile-granulosa-cell-tumors-bearing-akt1-mutations-provide-insights-into-tumor-biology-and-therapeutic-leads
#9
Aurélie Auguste, Laurianne Bessière, Anne-Laure Todeschini, Sandrine Caburet, Sabine Sarnacki, Jaime Prat, Emanuela D'angelo, Pierre De La Grange, Olivier Ariste, Fréderic Lemoine, Bérangère Legois, Charles Sultan, Alain Zider, Louise Galmiche, Nicolas Kalfa, Reiner A Veitia
Juvenile granulosa cell tumors (JGCTs) of the ovary are pediatric neoplasms representing 5% of all granulosa cell tumors (GCTs). Most GCTs are of adult type (AGCTs) and bear a mutation in the FOXL2 gene. The molecular basis of JGCTs is poorly understood, although mutations in the GNAS gene have been reported. We have detected in-frame duplications within the oncogene AKT1 in >60% of the JGCTs studied. Here, to evaluate the functional impact of these duplications and the existence of potential co-driver alterations, we have sequenced the transcriptome of four JGCTs and compared them with control transcriptomes...
December 1, 2015: Human Molecular Genetics
https://www.readbyqxmd.com/read/26356327/dual-loss-of-the-swi-snf-complex-atpases-smarca4-brg1-and-smarca2-brm-is-highly-sensitive-and-specific-for-small-cell-carcinoma-of-the-ovary-hypercalcaemic-type
#10
Anthony N Karnezis, Yemin Wang, Pilar Ramos, William Pd Hendricks, Esther Oliva, Emanuela D'Angelo, Jaime Prat, Marisa R Nucci, Torsten O Nielsen, Christine Chow, Samuel Leung, Friedrich Kommoss, Stefan Kommoss, Annacarolina Silva, Brigitte M Ronnett, Joseph T Rabban, David D Bowtell, Bernard E Weissman, Jeffrey M Trent, C Blake Gilks, David G Huntsman
Small cell carcinoma of the ovary, hypercalcaemic type (SCCOHT) is a lethal and sometimes familial ovarian tumour of young women and children. We and others recently discovered that over 90% of SCCOHTs harbour inactivating mutations in the chromatin remodelling gene SMARCA4 with concomitant loss of its encoded protein SMARCA4 (BRG1), one of two mutually exclusive ATPases of the SWI/SNF chromatin remodelling complex. To determine the specificity of SMARCA4 loss for SCCOHT, we examined the expression of SMARCA4 by immunohistochemistry in more than 3000 primary gynaecological tumours...
February 2016: Journal of Pathology
https://www.readbyqxmd.com/read/26241270/staging-classification-for-cancer-of-the-ovary-fallopian-tube-and-peritoneum-abridged-republication-of-guidelines-from-the-international-federation-of-gynecology-and-obstetrics-figo
#11
https://www.readbyqxmd.com/read/26110780/abridged-republication-of-figo-s-staging-classification-for-cancer-of-the-ovary-fallopian-tube-and-peritoneum
#12
Jaime Prat
Ovarian, fallopian tube, and peritoneal cancers have a similar clinical presentation and are treated similarly, and current evidence supports staging all 3 cancers in a single system. The primary site (i.e. ovary, fallopian tube, or peritoneum) should be designated where possible. The histologic type should be recorded. Intraoperative rupture ("surgical spill") is IC1; capsule ruptured before surgery or tumor on ovarian or fallopian tube surface is IC2; and positive peritoneal cytology with or without rupture is IC3...
October 1, 2015: Cancer
https://www.readbyqxmd.com/read/25934522/molecular-staging-of-gynecological-cancer-what-is-the-future
#13
REVIEW
Pratibha S Binder, Jaime Prat, David G Mutch
The purpose of cancer staging is to classify cancers into prognostic groups and to allow for comparison of treatment results and survival between patients and institutions. Staging for gynecologic cancers is based on extent of disease and metastasis, which was historically determined by physical examination and is now based on surgical and histologic examination of tumor specimens. Although the extent of disease is currently considered the most important predictor of recurrence and survival, current staging does not include molecular features that are associated with tumor aggressiveness, response to therapy, and prognosis...
August 2015: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/25890882/ovarian-fallopian-tube-and-peritoneal-cancer-staging-rationale-and-explanation-of-new-figo-staging-2013
#14
REVIEW
Jaime Prat
Ovarian, fallopian tube, and peritoneal cancers have a similar clinical presentation and are treated similarly, and current evidence supports staging all three cancers in a single system. The primary site (i.e., ovary, fallopian tube, or peritoneum) should be designated where possible. The histologic type should be recorded. Intraoperative rupture ("surgical spill") is IC1; capsule ruptured before surgery or tumor on ovarian or fallopian tube surface is IC2; and positive peritoneal cytology with or without rupture is IC3...
August 2015: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/25872889/figo-s-staging-classification-for-cancer-of-the-ovary-fallopian-tube-and-peritoneum-abridged-republication
#15
REVIEW
Jaime Prat
No abstract text is available yet for this article.
April 2015: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/25844549/simultaneous-carcinomas-of-the-breast-and-ovary-utility-of-pax-8-wt-1-and-gata3-for-distinguishing-independent-primary-tumors-from-metastases
#16
Inigo Espinosa, Alberto Gallardo, Emanuela D'Angelo, Ana Mozos, Enrique Lerma, Jaime Prat
Breast carcinomas rarely metastasize to the ovary and are even more rarely present clinically as primary ovarian tumors. However, patients with breast cancer not infrequently develop independent primary ovarian carcinomas. In these cases, distinction between independent primaries and metastatic tumors is crucial. Several comparative immunohistochemical studies have been reported, but few included significant clinicopathologic data and none investigated cases of ovarian and breast carcinomas from the same patients...
May 2015: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/25819291/abridged-republication-of-figo-s-staging-classification-for-cancer-of-the-ovary-fallopian-tube-and-peritoneum
#17
Jaime Prat
No abstract text is available yet for this article.
May 2015: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/25602940/monoclonal-antibody-targeted-fluorescein-5-isothiocyanate-labeled-biomimetic-nanoapatites-a-promising-fluorescent-probe-for-imaging-applications
#18
Francesca Oltolina, Luca Gregoletto, Donato Colangelo, Jaime Gómez-Morales, José Manuel Delgado-López, Maria Prat
Multifunctional biomimetic nanoparticles (NPs) are acquiring increasing interest as carriers in medicine and basic research since they can efficiently combine labels for subsequent tracking, moieties for specific cell targeting, and bioactive molecules, e.g., drugs. In particular, because of their easy synthesis, low cost, good biocompatibility, high resorbability, easy surface functionalization, and pH-dependent solubility, nanocrystalline apatites are promising candidates as nanocarriers. This work describes the synthesis and characterization of bioinspired apatite nanoparticles to be used as fluorescent nanocarriers targeted against the Met/hepatocyte growth factor receptor, which is considered a tumor associated cell surface marker of many cancers...
February 10, 2015: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/25219463/annexin-a2-as-predictor-biomarker-of-recurrent-disease-in-endometrial-cancer
#19
Lorena Alonso-Alconada, Maria Santacana, Pablo Garcia-Sanz, Laura Muinelo-Romay, Eva Colas, Cristina Mirantes, Marta Monge, Juan Cueva, Esther Oliva, Robert A Soslow, Maria Angeles Lopez, Jose Palacios, Jaime Prat, Joan Valls, Camilla Krakstad, Helga Salvesen, Antonio Gil-Moreno, Rafael Lopez-Lopez, Xavier Dolcet, Gema Moreno-Bueno, Jaume Reventos, Xavier Matias-Guiu, Miguel Abal
Endometrial carcinomas, the most common malignant tumour of the female genital tract, are usually diagnosed at an early stage with uterine-confined disease and an overall favourable prognosis. However, up to 20% of endometrial carcinomas will end up in recurrent disease, associated with a drop in survival and representing the major clinical challenge. Management of this group of risk patients relies on robust biomarkers that may predict which endometrial carcinomas will relapse. For this, we performed a proteomic analysis comparing primary lesions with recurrences and identified ANXA2 as a potential biomarker associated with recurrent disease that we further validated in an independent series of samples by immunohistochemistry...
April 15, 2015: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/25082067/the-new-figo-staging-system-for-ovarian-fallopian-tube-and-primary-peritoneal-cancer
#20
F Zeppernick, I Meinhold-Heerlein
INTRODUCTION: Recent molecular research has revolutionized the understanding of ovarian cancer. It is now non-controversial that the term ovarian cancer summarizes a heterogenous group of malignant epithelial tumors. Findings of large clinical trials investigating surgical and systemic therapeutic approaches have defined the most important prognostic parameters. Therefore, the oncology committee of FIGO, headed by the South African gynecologic oncologist Lynette Denny, took the effort to revise the FIGO classification of ovarian cancer that was implemented in 1988...
November 2014: Archives of Gynecology and Obstetrics
keyword
keyword
120515
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"