keyword
https://read.qxmd.com/read/38615479/endometrial-carcinoma-10%C3%A2-years-of-tcga-the-cancer-genome-atlas-a-critical-reappraisal-with-comments-on-figo-2023-staging
#1
REVIEW
Iñigo Espinosa, Emanuela D'Angelo, Jaime Prat
The Cancer Genome Atlas (TCGA) Research Network described 4 molecular subgroups of endometrial carcinomas with different outcome: 1) POLE ultramutated endometrioid carcinomas which have an indolent behavior; 2) microsatellite instability hypermutated endometrioid carcinomas associated with intermediate prognosis; 3) copy-number low endometrioid carcinomas also with intermediate prognosis; and 4) copy-number high predominantly serous (non-endometrioid) but also serous-like endometrioid carcinomas, almost always carrying TP53 mutations, with poor clinical outcome...
April 13, 2024: Gynecologic Oncology
https://read.qxmd.com/read/38588960/genomic-evolution-of-human-respiratory-syncytial-virus-during-a-decade-2013-2023-bridging-the-path-to-monoclonal-antibody-surveillance
#2
JOURNAL ARTICLE
Maria Piñana, Alejandra González-Sánchez, Cristina Andrés, Jorgina Vila, Anna Creus-Costa, Ignasi Prats-Méndez, Maria Arnedo-Muñoz, Narcís Saubi, Juliana Esperalba, Ariadna Rando, Patricia Nadal-Baron, Josep Quer, Juan José González-López, Pere Soler-Palacín, Jaime Martínez-Urtaza, Nieves Larrosa, Tomàs Pumarola, Andrés Antón
OBJECTIVES: This study investigated the prevalence, genetic diversity, and evolution of human respiratory syncytial virus (HRSV) in Barcelona from 2013 to 2023. METHODS: Respiratory specimens from patients with RTI suspicion at Hospital Universitari Vall d'Hebron were collected from October/2013 to May/2023 for laboratory-confirmation of respiratory viruses. Next-generation sequencing was performed in randomly-selected samples with Illumina technology. Phylogenetic analyses of whole genome sequences were performed with BEAST v1...
April 6, 2024: Journal of Infection
https://read.qxmd.com/read/38569228/expanding-the-phenotypic-spectrum-of-traf7-related-cardiac-facial-and-digital-anomalies-with-developmental-delay-report-of-11-new-cases-and-literature-review
#3
JOURNAL ARTICLE
Carmen Palma-Milla, Aina Prat-Planas, Emma Soengas-Gonda, Mónica Centeno-Pla, Jaime Sánchez-Pozo, Irene Lazaro-Rodriguez, Juan F Quesada-Espinosa, Ana Arteche-Lopez, Jonathan Olival, Marta Pacio-Miguez, María Palomares-Bralo, Fernando Santos-Simarro, Ramón Cancho-Candela, María Vázquez-López, Veronica Seidel, Antonio F Martinez-Monseny, Didac Casas-Alba, Daniel Grinberg, Susanna Balcells, Mercedes Serrano, Raquel Rabionet, Miguel A Martin, Roser Urreizti
BACKGROUND: TRAF7-related cardiac, facial, and digital anomalies with developmental delay (CAFDADD), a multisystemic neurodevelopmental disorder caused by germline missense variants in the TRAF7 gene, exhibits heterogeneous clinical presentations. METHODS: We present a detailed description of 11 new TRAF7-related CAFDADD cases, featuring eight distinct variants, including a novel one. RESULTS: Phenotypic analysis and a comprehensive review of the 58 previously reported cases outline consistent clinical presentations, emphasizing dysmorphic features, developmental delay, endocrine manifestations, and cardiac defects...
March 14, 2024: Pediatric Neurology
https://read.qxmd.com/read/38275289/bcas1-defines-a-heterogeneous-cell-population-in-diffuse-gliomas
#4
JOURNAL ARTICLE
Raquel Morales-Gallel, María José Ulloa-Navas, Patricia García-Tárraga, Ricardo Prat-Acín, Gaspar Reynés, Pedro Pérez-Borredá, Luis Rubio, Vivian Capilla-González, Jaime Ferrer-Lozano, José Manuel García-Verdugo
Oligodendrocyte precursor markers have become of great interest to identify new diagnostic and therapeutic targets for diffuse gliomas, since state-of-the-art studies point towards immature oligodendrocytes as a possible source of gliomagenesis. Brain enriched myelin associated protein 1 (BCAS1) is a novel marker of immature oligodendrocytes and was proposed to contribute to tumorigenesis in non-central nervous system tumors. However, BCAS1 role in diffuse glioma is still underexplored. This study analyzes the expression of BCAS1 in different tumor samples from patients with diffuse gliomas (17 oligodendrogliomas; 8 astrocytomas; 60 glioblastomas) and uncovers the molecular and ultrastructural features of BCAS1+ cells by immunostaining and electron microscopy...
January 24, 2024: Oncotarget
https://read.qxmd.com/read/37758451/gestational-choriocarcinoma
#5
REVIEW
Giorgio Bogani, Isabelle Ray-Coquard, David Mutch, Ignace Vergote, Pedro T Ramirez, Jaime Prat, Nicole Concin, Natalie Yan Li Ngoi, Robert L Coleman, Takayuki Enomoto, Kazuhiro Takehara, Hannelore Denys, Domenica Lorusso, Masashi Takano, Satoru Sagae, Pauline Wimberger, Yakir Segev, Se Ik Kim, Jae-Weon Kim, Fernanda Herrera, Andrea Mariani, Rebecca A Brooks, David Tan, Biagio Paolini, Valentina Chiappa, Mariangela Longo, Francesco Raspagliesi, Pierluigi Benedetti Panici, Violante Di Donato, Giuseppe Caruso, Nicoletta Colombo, Sandro Pignata, Gianfranco Zannoni, Giovanni Scambia, Bradley J Monk
Gestational choriocarcinoma accounts for 5% of gestational trophoblastic neoplasms. Approximately 50%, 25%, and 25% of gestational choriocarcinoma occur after molar pregnancies, term pregnancies, and other gestational events, respectively. The FIGO scoring system categorizes patients into low (score 0 to 6) and high risk (score 7 or more) choriocarcinoma. Single-agent and multi-agent chemotherapy are used in low- and high-risk patients, respectively. Chemotherapy for localized disease has a goal of eradication of disease without surgery and is associated with favorable prognosis and fertility preservation...
October 2, 2023: International Journal of Gynecological Cancer
https://read.qxmd.com/read/37673346/ovarian-high-grade-serous-carcinoma-with-transitional-like-set-morphology-a-homologous-recombination-deficient-tumor
#6
JOURNAL ARTICLE
Emanuela D'Angelo, Iñigo Espinosa, Lara Felicioni, Fiamma Buttitta, Jaime Prat
Thirteen years ago, we pointed out that ovarian transitional cell carcinomas (TCCs) and conventional high-grade serous carcinomas (HGSCs) had similar genetic alterations and clinical behavior. Consequently, ovarian TCC is now classified as a morphologic variant of HGSC. Defective homologous recombination, resulting from genetic or epigenetic inactivation of DNA damage repair genes, such as BRCA1/2, occurs in approximately 50% of the HGSCs. Although BRCA mutations have been associated with HGSCs with solid, pseudoendometrioid or transitional (SET) features, little is known about the role of non-BRCA homologous recombinationrepair (HRR) genes and the HRR status in these tumors...
November 2023: Human Pathology
https://read.qxmd.com/read/37446361/the-prognostic-significance-of-tumor-infiltrating-lymphocytes-pd-l1-brca-mutation-status-and-tumor-mutational-burden-in-early-stage-high-grade-serous-ovarian-carcinoma-a-study-by-the-spanish-group-for-ovarian-cancer-research-geico
#7
JOURNAL ARTICLE
David Pizarro, Ignacio Romero, Belén Pérez-Mies, Andrés Redondo, Tamara Caniego-Casas, Irene Carretero-Barrio, Eva Cristóbal, Ana Gutiérrez-Pecharromán, Ana Santaballa, Emanuela D'Angelo, David Hardisson, Begoña Vieites, Xavier Matías-Guiu, Purificación Estévez, Eva Guerra, Jaime Prat, Andrés Poveda, José Antonio López-Guerrero, José Palacios
Early stages are under-represented in studies on the molecular and immune features of high-grade serous ovarian carcinoma (HGSOC), and specific studies focused on early-stage HGSOC are required for a better prognostic stratification and to personalize chemotherapy. The aim of this study was to determine the prognostic significance of CD8+ and CD4+ tumor-infiltrating lymphocytes (TILs), tumoral cell PD-L1 expression, BRCA mutational status and tumor mutation burden (TMB) in early-stage HGSOC. A retrospective study was performed on stage I and II HGSOC from the Molecular Reclassification of Early Stages of Ovarian Cancer (RECLAMO) cohort from the Spanish Group of Ovarian Cancer Research (GEICO)...
July 6, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37311694/clinical-and-cost-outcomes-of-a-polyethylene-glycol-peg-coated-patch-versus-drainage-after-axillary-lymph-node-dissection-in-breast-cancer-results-from-a-multicentre-randomized-clinical-trial
#8
RANDOMIZED CONTROLLED TRIAL
Elvira Buch-Villa, Carlos Castañer-Puga, Silvia Delgado-Garcia, Carlos Fuster-Diana, Beatriz Vidal-Herrador, Francisco Ripoll-Orts, Tania Galeote-Quecedo, Antonio Prat, Myrian Andrés-Matias, Jaime Jimeno-Fraile, Ernesto Muñoz-Sorsona, Giovani Vento, Verónica Gumbau-Puchol, Marcos Adrianzen, Vicente López-Flor, Joaquín Ortega
BACKGROUND: The aim of this study was to compare the clinical outcomes between breast cancer patients who underwent axillary lymph node dissection with postoperative management using a polyethylene glycol-coated patch versus axillary drainage. The direct costs associated with both postoperative management strategies were also evaluated. METHODS: This was a multicentre RCT in women with breast cancer who underwent axillary lymph node dissection (ClinicalTrials.gov identifier: NCT04487561)...
August 11, 2023: British Journal of Surgery
https://read.qxmd.com/read/37114629/placental-site-trophoblastic-tumor-pstt-a-case-report-and-review-of-the-literature
#9
Claudia Zampacorta, Maria Paola Pasciuto, Benedetta Ferro, Alessandro Lucidi, Angel Sanchez Maestro, Inigo Espinosa, Emanuela D'Angelo, Jaime Prat
Placental site trophoblastic tumor (PSTT), also known as atypical choriocarcinoma, syncytioma, chorioepitheliosis or trophoblastic pseudotumor, is a rare gestational trophoblastic disease (0.25-5% of all trophoblastic tumors) and it is composed by neoplastic proliferation of intermediate trophoblasts at placental implantation site. It consists of aggregates or sheets of large, polyhedral to round, predominantly mononucleated cells with a characteristic vascular and myometrial invasion. Main differential diagnoses are gestational choriocarcinoma (GC) and epitelioid trophoblastic tumor (ETT)...
April 2023: Pathologica
https://read.qxmd.com/read/36863690/malignant-rhabdoid-tumors-of-the-vulva-versus-epithelioid-sarcomas-a-clinicopathologic-immunohistochemical-and-molecular-genetics-study
#10
JOURNAL ARTICLE
Iñigo Espinosa, Emanuela D'Angelo, Louise De Brot, Jaime Prat
It has been suggested that most, if not all, extrarenal rhabdoid tumors of the vulva represent "proximal-type" epithelioid sarcomas. To better understand rhabdoid tumors of the vulva, we studied the clinicopathologic, immunohistochemical (IHC), and molecular features of 8 of these tumors and 13 extragenital epithelioid sarcomas. IHC analysis for cytokeratin AE1/AE3, EMA, S100, CD34, ERG, smooth muscle actin, desmin, and SMARCB1 (INI1) was performed. Ultrastructural study was done in one vulvar rhabdoid tumor...
May 2023: Human Pathology
https://read.qxmd.com/read/36270281/deciphering-the-roadmap-of-in-vivo-reprogramming-toward-pluripotency
#11
JOURNAL ARTICLE
Dafni Chondronasiou, Jaime Martínez de Villarreal, Elena Melendez, Cian J Lynch, Natalia Del Pozo, Marta Kovatcheva, Mònica Aguilera, Neus Prats, Francisco X Real, Manuel Serrano
Differentiated cells can be converted into pluripotent stem cells by expressing the transcription factors OCT4, SOX2, KLF4, and MYC (OSKM) in a process known as reprogramming. Here, using single-cell RNA sequencing of pancreas undergoing reprogramming, we identify markers along the trajectory from acinar cell identity to pluripotency. These markers allow direct in situ visualization of cells undergoing dedifferentiation and acquiring features of early and advanced intermediate reprogramming. We also find that a fraction of cells do not dedifferentiate upon OSKM expression and are characterized by stress markers of the REG3 and AP-1 families...
October 7, 2022: Stem Cell Reports
https://read.qxmd.com/read/35022757/loss-of-humoral-response-3-months-after-sars-cov-2-vaccination-in-the-ckd-spectrum-the-multicentric-sencovac-study
#12
LETTER
Borja Quiroga, María José Soler, Alberto Ortiz, Amparo Bernat, Ana Beatriz Muñoz Díaz, Carlos Jesús Jarava Mantecón, Virginia Olinda Gómez Pérez, Carmen Calderón González, Michal Cervienka, Auxiliadora Mazuecos, Juan Manuel Cazorla, Manuel Carnerero Di Riso, Shaira Martínez, Mayra Ortega Diaz, Rafael Lucena Valverde, María Gabriela Sánchez Márquez, Carolina Lancho Novillo, Emilio González Parra, Carolina Gracia-Iguacel, María Teresa Rodrigo De Tomas, María Cinta Aguilar Cervera, Martín Giorgi, Patricia Muñoz Ramos, Nicolás Macías Carmona, Néstor Toapanta, Secundino Cigarrán, Juan Carlos Ruiz San Millán, Raquel Santana Estupiñán, Marta Crespo, Blanca Villacorta Linaza, María Isabel Jimeno Martín, Laura Rodríguez-Osorio Jiménez, Sagrario Soriano, Dioné González Ferri, María Soledad Pizarro Sánchez, Alejandra Yugueros, Alba Leyva, José Rojas, Ron T Gansevoort, Patricia de Sequera
No abstract text is available yet for this article.
April 25, 2022: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/34105519/atypical-endometrial-hyperplasia-low-grade-much-ado-about-nothing
#13
COMPARATIVE STUDY
Emanuela D'Angelo, Iñigo Espinosa, Valentina Cipriani, Justyna Szafranska, Mattia Barbareschi, Jaime Prat
Atypical endometrial hyperplasia (AEH) is considered a precursor of endometrioid carcinoma. The 2020 World Health Organization (WHO) classification divides endometrial hyperplasia into 2 categories: hyperplasia without atypia and atypical hyperplasia/endometrioid intraepithelial neoplasia (EIN); however, this classification does not consider the degree of nuclear atypia. We graded nuclear atypia for estimating the risk of finding carcinoma at hysterectomy. Also, we investigated genes involved in endometrial carcinogenesis including mismatch repair (MMR) genes and ARID1A, PIK3CA, PTEN, KRAS, and CTNNB1...
July 1, 2021: American Journal of Surgical Pathology
https://read.qxmd.com/read/34061701/dr-juan-rosai-1940-2020
#14
JOURNAL ARTICLE
Jaime Prat
No abstract text is available yet for this article.
June 1, 2021: International Journal of Surgical Pathology
https://read.qxmd.com/read/33627643/flexible-categorization-in-perceptual-decision-making
#15
JOURNAL ARTICLE
Genís Prat-Ortega, Klaus Wimmer, Alex Roxin, Jaime de la Rocha
Perceptual decisions rely on accumulating sensory evidence. This computation has been studied using either drift diffusion models or neurobiological network models exhibiting winner-take-all attractor dynamics. Although both models can account for a large amount of data, it remains unclear whether their dynamics are qualitatively equivalent. Here we show that in the attractor model, but not in the drift diffusion model, an increase in the stimulus fluctuations or the stimulus duration promotes transitions between decision states...
February 24, 2021: Nature Communications
https://read.qxmd.com/read/33513811/crystallization-luminescence-and-cytocompatibility-of-hexagonal-calcium-doped-terbium-phosphate-hydrate-nanoparticles
#16
JOURNAL ARTICLE
Jaime Gómez-Morales, Raquel Fernández-Penas, Ismael Romero-Castillo, Cristóbal Verdugo-Escamilla, Duane Choquesillo-Lazarte, Annarita D'Urso, Maria Prat, Jorge Fernando Fernández-Sánchez
Luminescent lanthanide-containing biocompatible nanosystems represent promising candidates as nanoplatforms for bioimaging applications. Herein, citrate-functionalized calcium-doped terbium phosphate hydrate nanophosphors of the rhabdophane type were prepared at different synthesis times and different Ca2+ /Tb3+ ratios by a bioinspired crystallization method consisting of thermal decomplexing of Ca2+ /Tb3+ /citrate/phosphate/carbonate solutions. Nanoparticles were characterized by XRD, TEM, SEM, HR-TEM, FTIR, Raman, Thermogravimetry, inductively coupled plasma spectroscopy, thermoanalysis, dynamic light scattering, electrophoretic mobility, and fluorescence spectroscopy...
January 27, 2021: Nanomaterials
https://read.qxmd.com/read/32482579/talipes-equinovarus-treatment-in-infants-treated-by-the-ponseti-method-compared-with-posterior-only-release-a-mid-childhood-comparison-of-results
#17
JOURNAL ARTICLE
Albert Ferrando, Marta Salom, Alvaro Page, Alexandre Perez-Girbes, Carlos Atienza, M Fe Minguez, Jaime Prat
The aim of this study is to evaluate children in middle childhood with clubfoot treated with Ponseti method vs posterior-only release and to compare their results to a control group with 4 modules (physical examination, gait study, radiographic measurements, and questionnaires). From 01/01/2004 until 01/01/2009, 31 children (45 feet) were treated with the posterior-only release protocol and 22 patients (34 feet) were treated with the Ponseti method. In 2016, patients were evaluated and compared with 25 children without neuromuscular disorders...
September 2020: Journal of Foot and Ankle Surgery
https://read.qxmd.com/read/32341498/molecular-and-clinicopathologic-characterization-of-intravenous-leiomyomatosis
#18
JOURNAL ARTICLE
Zehra Ordulu, Hongyan Chai, Gang Peng, Anna G McDonald, Michele De Nictolis, Eugenia Garcia-Fernandez, David Hardisson, Jaime Prat, Peining Li, Pei Hui, Esther Oliva, Natalia Buza
Intravenous leiomyomatosis (IVL) is an unusual uterine smooth muscle proliferation that can be associated with aggressive clinical behavior despite a histologically benign appearance. It has some overlapping molecular characteristics with both uterine leiomyoma and leiomyosarcoma based on limited genetic data. In this study, we assessed the clinical and morphological characteristics of 28 IVL and their correlation with molecular features and protein expression, using array comparative genomic hybridization (aCGH) and Cyclin D1, p16, phosphorylated-Rb, SMARCB1, SOX10, CAIX, SDHB and FH immunohistochemistry...
September 2020: Modern Pathology
https://read.qxmd.com/read/32105305/global-retinoblastoma-presentation-and-analysis-by-national-income-level
#19
JOURNAL ARTICLE
Ido Didi Fabian, Elhassan Abdallah, Shehu U Abdullahi, Rula A Abdulqader, Sahadatou Adamou Boubacar, Dupe S Ademola-Popoola, Adedayo Adio, Armin R Afshar, Priyanka Aggarwal, Ada E Aghaji, Alia Ahmad, Marliyanti N R Akib, Lamis Al Harby, Mouroge H Al Ani, Aygun Alakbarova, Silvia Alarcón Portabella, Safaa A F Al-Badri, Ana Patricia A Alcasabas, Saad A Al-Dahmash, Amanda Alejos, Ernesto Alemany-Rubio, Amadou I Alfa Bio, Yvania Alfonso Carreras, Christiane Al-Haddad, Hamoud H Y Al-Hussaini, Amany M Ali, Donjeta B Alia, Mazin F Al-Jadiry, Usama Al-Jumaily, Hind M Alkatan, Charlotta All-Eriksson, Ali A R M Al-Mafrachi, Argentino A Almeida, Khalifa M Alsawidi, Athar A S M Al-Shaheen, Entissar H Al-Shammary, Primawita O Amiruddin, Romanzo Antonino, Nicholas J Astbury, Hatice T Atalay, La-Ongsri Atchaneeyasakul, Rose Atsiaya, Taweevat Attaseth, Than H Aung, Silvia Ayala, Baglan Baizakova, Julia Balaguer, Ruhengiz Balayeva, Walentyna Balwierz, Honorio Barranco, Covadonga Bascaran, Maja Beck Popovic, Raquel Benavides, Sarra Benmiloud, Nissrine Bennani Guebessi, Rokia C Berete, Jesse L Berry, Anirban Bhaduri, Sunil Bhat, Shelley J Biddulph, Eva M Biewald, Nadia Bobrova, Marianna Boehme, H C Boldt, Maria Teresa B C Bonanomi, Norbert Bornfeld, Gabrielle C Bouda, Hédi Bouguila, Amaria Boumedane, Rachel C Brennan, Bénédicte G Brichard, Jassada Buaboonnam, Patricia Calderón-Sotelo, Doris A Calle Jara, Jayne E Camuglia, Miriam R Cano, Michael Capra, Nathalie Cassoux, Guilherme Castela, Luis Castillo, Jaume Català-Mora, Guillermo L Chantada, Shabana Chaudhry, Sonal S Chaugule, Argudit Chauhan, Bhavna Chawla, Violeta S Chernodrinska, Faraja S Chiwanga, Tsengelmaa Chuluunbat, Krzysztof Cieslik, Ruellyn L Cockcroft, Codruta Comsa, Zelia M Correa, Maria G Correa Llano, Timothy W Corson, Kristin E Cowan-Lyn, Monika Csóka, Xuehao Cui, Isac V Da Gama, Wantanee Dangboon, Anirban Das, Sima Das, Jacquelyn M Davanzo, Alan Davidson, Patrick De Potter, Karina Q Delgado, Hakan Demirci, Laurence Desjardins, Rosdali Y Diaz Coronado, Helen Dimaras, Andrew J Dodgshun, Craig Donaldson, Carla R Donato Macedo, Monica D Dragomir, Yi Du, Magritha Du Bruyn, Kemala S Edison, I Wayan Eka Sutyawan, Asmaa El Kettani, Amal M Elbahi, James E Elder, Dina Elgalaly, Alaa M Elhaddad, Moawia M Ali Elhassan, Mahmoud M Elzembely, Vera A Essuman, Ted Grimbert A Evina, Zehra Fadoo, Adriana C Fandiño, Mohammad Faranoush, Oluyemi Fasina, Delia D P G Fernández, Ana Fernández-Teijeiro, Allen Foster, Shahar Frenkel, Ligia D Fu, Soad L Fuentes-Alabi, Brenda L Gallie, Moira Gandiwa, Juan L Garcia, David García Aldana, Pascale Y Gassant, Jennifer A Geel, Fariba Ghassemi, Ana V Girón, Zelalem Gizachew, Marco A Goenz, Aaron S Gold, Maya Goldberg-Lavid, Glen A Gole, Nir Gomel, Efren Gonzalez, Graciela Gonzalez Perez, Liudmira González-Rodríguez, Henry N Garcia Pacheco, Jaime Graells, Liz Green, Pernille A Gregersen, Nathalia D A K Grigorovski, Koffi M Guedenon, D Sanjeeva Gunasekera, Ahmet K Gündüz, Himika Gupta, Sanjiv Gupta, Theodora Hadjistilianou, Patrick Hamel, Syed A Hamid, Norhafizah Hamzah, Eric D Hansen, J William Harbour, M Elizabeth Hartnett, Murat Hasanreisoglu, Sadiq Hassan, Shadab Hassan, Stanislava Hederova, Jose Hernandez, Lorelay Marie Carcamo Hernandez, Laila Hessissen, Diriba F Hordofa, Laura C Huang, G B Hubbard, Marlies Hummlen, Kristina Husakova, Allawi N Hussein Al-Janabi, Russo Ida, Vesna R Ilic, Vivekaraj Jairaj, Irfan Jeeva, Helen Jenkinson, Xunda Ji, Dong Hyun Jo, Kenneth P Johnson, William J Johnson, Michael M Jones, Theophile B Amani Kabesha, Rolande L Kabore, Swathi Kaliki, Abubakar Kalinaki, Mehmet Kantar, Ling-Yuh Kao, Tamar Kardava, Rejin Kebudi, Tomas Kepak, Naama Keren-Froim, Zohora J Khan, Hussain A Khaqan, Phara Khauv, Wajiha J Kheir, Vikas Khetan, Alireza Khodabande, Zaza Khotenashvili, Jonathan W Kim, Jeong Hun Kim, Hayyam Kiratli, Tero T Kivelä, Artur Klett, Jess Elio Kosh Komba Palet, Dalia Krivaitiene, Mariana Kruger, Kittisak Kulvichit, Mayasari W Kuntorini, Alice Kyara, Eva S Lachmann, Carol P S Lam, Geoffrey C Lam, Scott A Larson, Slobodanka Latinovic, Kelly D Laurenti, Bao Han A Le, Karin Lecuona, Amy A Leverant, Cairui Li, Ben Limbu, Quah Boon Long, Juan P López, Robert M Lukamba, Livia Lumbroso, Sandra Luna-Fineman, Delfitri Lutfi, Lesia Lysytsia, George N Magrath, Amita Mahajan, Abdul Rahim Majeed, Erika Maka, Mayuri Makan, Emil K Makimbetov, Chatonda Manda, Nieves Martín Begue, Lauren Mason, John O Mason, Ibrahim O Matende, Miguel Materin, Clarissa C D S Mattosinho, Marchelo Matua, Ismail Mayet, Freddy B Mbumba, John D McKenzie, Aurora Medina-Sanson, Azim Mehrvar, Aemero A Mengesha, Vikas Menon, Gary John V D Mercado, Marilyn B Mets, Edoardo Midena, Divyansh K C Mishra, Furahini G Mndeme, Ahmed A Mohamedani, Mona T Mohammad, Annette C Moll, Margarita M Montero, Rosa A Morales, Claude Moreira, Prithvi Mruthyunjaya, Mchikirwa S Msina, Gerald Msukwa, Sangeeta S Mudaliar, Kangwa I Muma, Francis L Munier, Gabriela Murgoi, Timothy G Murray, Kareem O Musa, Asma Mushtaq, Hamzah Mustak, Okwen M Muyen, Gita Naidu, Akshay Gopinathan Nair, Larisa Naumenko, Paule Aïda Ndoye Roth, Yetty M Nency, Vladimir Neroev, Hang Ngo, Rosa M Nieves, Marina Nikitovic, Elizabeth D Nkanga, Henry Nkumbe, Murtuza Nuruddin, Mutale Nyaywa, Ghislaine Obono-Obiang, Ngozi C Oguego, Andrzej Olechowski, Scott C N Oliver, Peter Osei-Bonsu, Diego Ossandon, Manuel A Paez-Escamilla, Halimah Pagarra, Sally L Painter, Vivian Paintsil, Luisa Paiva, Bikramjit P Pal, Mahesh Shanmugam Palanivelu, Ruzanna Papyan, Raffaele Parrozzani, Manoj Parulekar, Claudia R Pascual Morales, Katherine E Paton, Katarzyna Pawinska-Wasikowska, Jacob Pe'er, Armando Peña, Sanja Peric, Chau T M Pham, Remezo Philbert, David A Plager, Pavel Pochop, Rodrigo A Polania, Vladimir G Polyakov, Manca T Pompe, Jonathan J Pons, Daphna Prat, Vireak Prom, Ignatius Purwanto, Ali O Qadir, Seema Qayyum, Jiang Qian, Ardizal Rahman, Salman Rahman, Jamalia Rahmat, Purnima Rajkarnikar, Rajesh Ramanjulu, Aparna Ramasubramanian, Marco A Ramirez-Ortiz, Léa Raobela, Riffat Rashid, M Ashwin Reddy, Ehud Reich, Lorna A Renner, David Reynders, Dahiru Ribadu, Mussagy M Riheia, Petra Ritter-Sovinz, Duangnate Rojanaporn, Livia Romero, Soma R Roy, Raya H Saab, Svetlana Saakyan, Ahmed H Sabhan, Mandeep S Sagoo, Azza M A Said, Rohit Saiju, Beatriz Salas, Sonsoles San Román Pacheco, Gissela L Sánchez, Phayvanh Sayalith, Trish A Scanlan, Amy C Schefler, Judy Schoeman, Ahad Sedaghat, Stefan Seregard, Rachna Seth, Ankoor S Shah, Shawkat A Shakoor, Manoj K Sharma, Sadik T Sherief, Nandan G Shetye, Carol L Shields, Sorath Noorani Siddiqui, Sidi Sidi Cheikh, Sónia Silva, Arun D Singh, Niharika Singh, Usha Singh, Penny Singha, Rita S Sitorus, Alison H Skalet, Hendrian D Soebagjo, Tetyana Sorochynska, Grace Ssali, Andrew W Stacey, Sandra E Staffieri, Erin D Stahl, Christina Stathopoulos, Branka Stirn Kranjc, David K Stones, Caron Strahlendorf, Maria Estela Coleoni Suarez, Sadia Sultana, Xiantao Sun, Meryl Sundy, Rosanne Superstein, Eddy Supriyadi, Supawan Surukrattanaskul, Shigenobu Suzuki, Karel Svojgr, Fatoumata Sylla, Gevorg Tamamyan, Deborah Tan, Alketa Tandili, Fanny F Tarrillo Leiva, Maryam Tashvighi, Bekim Tateshi, Edi S Tehuteru, Luiz F Teixeira, Kok Hoi Teh, Tuyisabe Theophile, Helen Toledano, Doan L Trang, Fousseyni Traoré, Sumalin Trichaiyaporn, Samuray Tuncer, Harba Tyau-Tyau, Ali B Umar, Emel Unal, Ogul E Uner, Steen F Urbak, Tatiana L Ushakova, Rustam H Usmanov, Sandra Valeina, Milo van Hoefen Wijsard, Adisai Varadisai, Liliana Vasquez, Leon O Vaughan, Nevyana V Veleva-Krasteva, Nishant Verma, Andi A Victor, Maris Viksnins, Edwin G Villacís Chafla, Vicktoria Vishnevskia-Dai, Tushar Vora, Antonio E Wachtel, Werner Wackernagel, Keith Waddell, Patricia D Wade, Amina H Wali, Yi-Zhuo Wang, Avery Weiss, Matthew W Wilson, Amelia D C Wime, Atchareeya Wiwatwongwana, Damrong Wiwatwongwana, Charlotte Wolley Dod, Phanthipha Wongwai, Daoman Xiang, Yishuang Xiao, Jason C Yam, Huasheng Yang, Jenny M Yanga, Muhammad A Yaqub, Vera A Yarovaya, Andrey A Yarovoy, Huijing Ye, Yacoub A Yousef, Putu Yuliawati, Arturo M Zapata López, Ekhtelbenina Zein, Chengyue Zhang, Yi Zhang, Junyang Zhao, Xiaoyu Zheng, Katsiaryna Zhilyaeva, Nida Zia, Othman A O Ziko, Marcia Zondervan, Richard Bowman
IMPORTANCE: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale. OBJECTIVES: To report the retinoblastoma stage at diagnosis in patients across the world during a single year, to investigate associations between clinical variables and national income level, and to investigate risk factors for advanced disease at diagnosis...
May 1, 2020: JAMA Oncology
https://read.qxmd.com/read/31979272/eu-doped-citrate-coated-carbonated-apatite-luminescent-nanoprobes-for-drug-delivery
#20
JOURNAL ARTICLE
Ylenia Jabalera, Francesca Oltolina, Maria Prat, Concepcion Jimenez-Lopez, Jorge F Fernández-Sánchez, Duane Choquesillo-Lazarte, Jaime Gómez-Morales
In the field of Nanomedicine, there is an increasing demand for new inorganic nanophosphors with low cytotoxicity and efficient loading-release ability of drugs for applications in bioimaging and drug delivery. This work assesses the potentiality of matured Eu-doped citrate-coated carbonated apatite nanoparticles to be used as theranostic platforms, for bioimaging, as luminescent nanoprobes, and for drug delivery applications, using Doxorubicin as a model drug. The drug adsorption isotherm fits the Langmuir-Freundlich (LF) model, showing that the Eu:cit-cAp nanoparticles can carry a maximum of 0...
January 23, 2020: Nanomaterials
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