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Jaime prat

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https://www.readbyqxmd.com/read/28806082/the-discovery-of-novel-antimalarial-aminoxadiazoles-as-a-promising-nonendoperoxide-scaffold
#1
Elena Sandoval, María José Lafuente-Monasterio, María J Almela, Pablo Castañeda, María Belén Jiménez Díaz, María S Martínez-Martínez, Jaume Vidal, Íñigo Angulo-Barturen, Paul Bamborough, Jeremy Burrows, Nicholas Cammack, María J Chaparro, José M Coterón, Cristina de Cozar, Benigno Crespo, Beatriz Díaz, Gerard Drewes, Esther Fernández, Santiago Ferrer-Bazaga, María Teresa Fraile, Francisco J Gamo, Sonja Ghidelli-Disse, Rubén Gómez, John Haselden, Sophie Huss, María Luisa León, Jaime de Mercado, Simon J F Macdonald, José Ignacio Martín Hernando, Sara Prats, Margarita Puente, Anne Rodríguez, Juan C de la Rosa, Lourdes Rueda, Carolyn Selenski, Paul Willis, David M Wilson, Michael Witty, Félix Calderón
Since the appearance of resistance to the current front-line antimalarial treatments, ACTs (artemisinin combination therapies), the discovery of novel chemical entities to treat the disease is recognized as a major global health priority. From the GSK antimalarial set, we identified an aminoxadiazole with an antiparasitic profile comparable with artemisinin (1), with no cross-resistance in a resistant strains panel and a potential new mode of action. A medicinal chemistry program allowed delivery of compounds such as 19 with high solubility in aqueous media, an acceptable toxicological profile, and oral efficacy...
August 14, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28601659/endometrioid-endometrial-carcinomas-with-melf-type-of-myoinvasion-role-of-immunohistochemistry-in-the-detection-of-occult-lymph-node-metastases-and-their-clinical-significance
#2
Iñigo Espinosa, Neus Serrat, Gian Franco Zannoni, Ramón Rovira, Emanuela D'Angelo, Jaime Prat
In endometrioid endometrial carcinomas (EEC), MELF (microcystic, elongated and fragmented) myoinvasion is associated with easily overlooked lymph node metastases; however, the role of immunohistochemistry in their detection and their clinical significance have not been addressed. We identified MELF in 43 of 101 (43%) myoinvasive EECs. Nodes were removed in 49 (49%), 25 with MELF and 24 without MELF. Metastases were initially reported in 3 of the former (12%) and 2 of the latter (8%). All negative nodes were reviewed and cytokeratin immunohistochemistry was performed...
June 7, 2017: Human Pathology
https://www.readbyqxmd.com/read/28498284/undifferentiated-and-dedifferentiated-endometrial-carcinomas-with-pole-exonuclease-domain-mutations-have-a-favorable-prognosis
#3
Iñigo Espinosa, Cheng-Han Lee, Emanuela D'Angelo, José Palacios, Jaime Prat
POLE exonuclease domain mutations have recently been described in undifferentiated endometrial carcinoma but, because of the rarity of this aggressive type of endometrial cancer, their prognostic significance is unknown. We have analyzed the immunophenotype (ARID1A, MLH1, PMS2, MSH2, MSH6, p53, β-catenin, and SMARCB1) and mutational status (POLE, PIK3CA, and PTEN) of 21 undifferentiated carcinomas (8 undifferentiated and 13 dedifferentiated carcinomas). Loss of ARID1A expression was observed in 9 of 19 cases (47%), loss of expression of at least 1 DNA mismatch repair protein in 7 (7/21; 33%), and p53 immunoreaction was aberrant (mutated/inactivated) in 11 cases (11/21; 52%)...
August 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28277307/pathology-of-borderline-and-invasive-cancers
#4
REVIEW
Jaime Prat
Epithelial ovarian tumors are heterogeneous neoplasms primarily classified according to cell type. They are further subdivided into benign, borderline, and malignant (carcinomas), and this subdivision is very important as it correlates with behavior. Borderline ovarian tumors show epithelial proliferation higher than that seen in their benign counterparts and variable nuclear atypia; however, in contrast to carcinomas, there is no destructive stromal invasion, and their prognosis is much better. Ovarian carcinomas are the most common ovarian cancers and the most lethal gynecological malignancies...
May 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28078436/adhering-to-the-2014-who-terminology-on-borderline-ovarian-tumors
#5
COMMENT
Jaime Prat
No abstract text is available yet for this article.
February 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27997699/chromatin-remodelling-and-dna-repair-genes-are-frequently-mutated-in-endometrioid-endometrial-carcinoma
#6
Pablo García-Sanz, Juan Carlos Triviño, Alba Mota, María Pérez López, Eva Colás, Alejandro Rojo-Sebastián, Ángel García, Sonia Gatius, María Ruiz, Jaime Prat, Rafael López-López, Miguel Abal, Antonio Gil-Moreno, Jaume Reventós, Xavier Matias-Guiu, Gema Moreno-Bueno
In developed countries, endometrial carcinoma is the most common cancer that affects the female genital tract. Endometrial carcinoma is divided into two main histological types, type I or endometrioid and type II or non-endometrioid, each of which have characteristic, although not exclusive, molecular alterations and mutational profiles. Nevertheless, information about the implication and relevance of some of these genes in this disease is lacking. We sought here to identify new recurrently mutated genes in endometrioid cancers that play a role in tumourigenesis and that influence the clinical outcome...
April 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27895324/molecular-genetic-heterogeneity-in-undifferentiated-endometrial-carcinomas
#7
Juan M Rosa-Rosa, Susanna Leskelä, Eva Cristóbal-Lana, Almudena Santón, Ma Ángeles López-García, Gloria Muñoz, Belen Pérez-Mies, Michele Biscuola, Jaime Prat, Oliva E Esther, Robert A Soslow, Xavier Matias-Guiu, Jose Palacios
No abstract text is available yet for this article.
December 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27491810/molecular-genetic-heterogeneity-in-undifferentiated-endometrial-carcinomas
#8
Juan M Rosa-Rosa, Susanna Leskelä, Eva Cristóbal-Lana, Almudena Santón, Ma Ángeles López-García, Gloria Muñoz, Belen Pérez-Mies, Michele Biscuola, Jaime Prat, Oliva E Esther, Robert A Soslow, Xavier Matias-Guiu, Jose Palacios
Undifferentiated and dedifferentiated endometrial carcinomas are rare and highly aggressive subtypes of uterine cancer, not well characterized at a molecular level. To investigate whether dedifferentiated carcinomas carry molecular genetic alterations similar to those of pure undifferentiated carcinomas, and to gain insight into the pathogenesis of these tumors, we selected a cohort of 18 undifferentiated endometrial carcinomas, 8 of them with a well-differentiated endometrioid carcinoma component (dedifferentiated endometrioid carcinomas), and studied them by immunohistochemistry and massive parallel and Sanger sequencing...
November 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27346574/cd8-down-regulation-on-cytotoxic-t-lymphocytes-of-patients-with-endometrioid-endometrial-carcinomas
#9
Mónica Pascual-García, Cristina Bértolo, Juan C Nieto, Neus Serrat, Íñigo Espinosa, Emanuela D'Angelo, Raquel Muñoz, Ramón Rovira, Silvia Vidal, Jaime Prat
Carcinogenesis is a multistep process in which cancer cells and tumor stroma cells play important roles. T lymphocytes are immune constituents of tumor stroma and play a crucial function in anti-tumor response. By immunohistochemistry and flow cytometry, we studied T cytotoxic (CTLs) and T helper lymphocyte distribution and percentage in the tumor microenvironment and peripheral blood from 35 patients with endometrioid endometrial carcinomas (EEC). We also studied 23 healthy donors' blood samples as a control group...
October 2016: Human Pathology
https://www.readbyqxmd.com/read/26975040/mixed-and-ambiguous-endometrial-carcinomas-a-heterogenous-group-of-tumors-with-different-clinicopathologic-and-molecular-genetic-features
#10
Iñigo Espinosa, Emanuela D'Angelo, José Palacios, Jaime Prat
Besides endometrioid, serous, and clear cell carcinomas, there are endometrial carcinomas exhibiting mixed and ambiguous morphologic features. We have analyzed the immunophenotype (p53, p16, β-catenin, ER, HNF-1B, MLH1, and Ki-67) and mutational status (PTEN, KRAS, PIK3CA, and POLE) of 7 mixed carcinomas and 13 ambiguous carcinomas, all of them classified initially as mixed carcinomas. Only 2 of the 7 (28%) mixed carcinomas showed different immunophenotypes in different components. All but 2 tumors (5/7, 71%) overexpressed p53 and p16 and were negative for ER...
July 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/26961430/-in-memoriam-jaime-campos-castello-1940-2015
#11
José M Prats-Viñas
No abstract text is available yet for this article.
March 16, 2016: Revista de Neurologia
https://www.readbyqxmd.com/read/26433670/pathology-of-cancers-of-the-female-genital-tract
#12
Jaime Prat
No abstract text is available yet for this article.
October 2015: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/26433669/the-future-role-of-molecular-staging-in-gynecologic-cancer
#13
Pratibha S Binder, Jaime Prat, David G Mutch
No abstract text is available yet for this article.
October 2015: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/26433666/uterine-sarcomas
#14
Jaime Prat, 'Nomonde Mbatani
No abstract text is available yet for this article.
October 2015: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/26362254/molecular-analyses-of-juvenile-granulosa-cell-tumors-bearing-akt1-mutations-provide-insights-into-tumor-biology-and-therapeutic-leads
#15
Aurélie Auguste, Laurianne Bessière, Anne-Laure Todeschini, Sandrine Caburet, Sabine Sarnacki, Jaime Prat, Emanuela D'angelo, Pierre De La Grange, Olivier Ariste, Fréderic Lemoine, Bérangère Legois, Charles Sultan, Alain Zider, Louise Galmiche, Nicolas Kalfa, Reiner A Veitia
Juvenile granulosa cell tumors (JGCTs) of the ovary are pediatric neoplasms representing 5% of all granulosa cell tumors (GCTs). Most GCTs are of adult type (AGCTs) and bear a mutation in the FOXL2 gene. The molecular basis of JGCTs is poorly understood, although mutations in the GNAS gene have been reported. We have detected in-frame duplications within the oncogene AKT1 in >60% of the JGCTs studied. Here, to evaluate the functional impact of these duplications and the existence of potential co-driver alterations, we have sequenced the transcriptome of four JGCTs and compared them with control transcriptomes...
December 1, 2015: Human Molecular Genetics
https://www.readbyqxmd.com/read/26356327/dual-loss-of-the-swi-snf-complex-atpases-smarca4-brg1-and-smarca2-brm-is-highly-sensitive-and-specific-for-small-cell-carcinoma-of-the-ovary-hypercalcaemic-type
#16
Anthony N Karnezis, Yemin Wang, Pilar Ramos, William Pd Hendricks, Esther Oliva, Emanuela D'Angelo, Jaime Prat, Marisa R Nucci, Torsten O Nielsen, Christine Chow, Samuel Leung, Friedrich Kommoss, Stefan Kommoss, Annacarolina Silva, Brigitte M Ronnett, Joseph T Rabban, David D Bowtell, Bernard E Weissman, Jeffrey M Trent, C Blake Gilks, David G Huntsman
Small cell carcinoma of the ovary, hypercalcaemic type (SCCOHT) is a lethal and sometimes familial ovarian tumour of young women and children. We and others recently discovered that over 90% of SCCOHTs harbour inactivating mutations in the chromatin remodelling gene SMARCA4 with concomitant loss of its encoded protein SMARCA4 (BRG1), one of two mutually exclusive ATPases of the SWI/SNF chromatin remodelling complex. To determine the specificity of SMARCA4 loss for SCCOHT, we examined the expression of SMARCA4 by immunohistochemistry in more than 3000 primary gynaecological tumours...
February 2016: Journal of Pathology
https://www.readbyqxmd.com/read/26241270/staging-classification-for-cancer-of-the-ovary-fallopian-tube-and-peritoneum-abridged-republication-of-guidelines-from-the-international-federation-of-gynecology-and-obstetrics-figo
#17
https://www.readbyqxmd.com/read/26110780/abridged-republication-of-figo-s-staging-classification-for-cancer-of-the-ovary-fallopian-tube-and-peritoneum
#18
Jaime Prat
Ovarian, fallopian tube, and peritoneal cancers have a similar clinical presentation and are treated similarly, and current evidence supports staging all 3 cancers in a single system. The primary site (i.e. ovary, fallopian tube, or peritoneum) should be designated where possible. The histologic type should be recorded. Intraoperative rupture ("surgical spill") is IC1; capsule ruptured before surgery or tumor on ovarian or fallopian tube surface is IC2; and positive peritoneal cytology with or without rupture is IC3...
October 1, 2015: Cancer
https://www.readbyqxmd.com/read/25934522/molecular-staging-of-gynecological-cancer-what-is-the-future
#19
REVIEW
Pratibha S Binder, Jaime Prat, David G Mutch
The purpose of cancer staging is to classify cancers into prognostic groups and to allow for comparison of treatment results and survival between patients and institutions. Staging for gynecologic cancers is based on extent of disease and metastasis, which was historically determined by physical examination and is now based on surgical and histologic examination of tumor specimens. Although the extent of disease is currently considered the most important predictor of recurrence and survival, current staging does not include molecular features that are associated with tumor aggressiveness, response to therapy, and prognosis...
August 2015: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/25890882/ovarian-fallopian-tube-and-peritoneal-cancer-staging-rationale-and-explanation-of-new-figo-staging-2013
#20
REVIEW
Jaime Prat
Ovarian, fallopian tube, and peritoneal cancers have a similar clinical presentation and are treated similarly, and current evidence supports staging all three cancers in a single system. The primary site (i.e., ovary, fallopian tube, or peritoneum) should be designated where possible. The histologic type should be recorded. Intraoperative rupture ("surgical spill") is IC1; capsule ruptured before surgery or tumor on ovarian or fallopian tube surface is IC2; and positive peritoneal cytology with or without rupture is IC3...
August 2015: Best Practice & Research. Clinical Obstetrics & Gynaecology
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