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https://www.readbyqxmd.com/read/28817352/arhgap29-mutation-is-associated-with-abnormal-oral-epithelial-adhesions
#1
B J Paul, K Palmer, J C Sharp, C H Pratt, S A Murray, M Dunnwald
Nonsyndromic cleft lip and/or palate (NSCL/P) is a prevalent birth defect of complex etiology. Previous studies identified mutations in ARHGAP29 associated with an increased risk for NSCL/P. To investigate the effects of ARHGAP29 in vivo, we generated a novel murine allele by inserting a point mutation identified in a patient with NSCL/P. This single-nucleotide variation of ARHGAP29 translates to an early nonsense mutation (K326X), presumably resulting in loss-of-function (LoF). Embryos from Arhgap29(K326X/+) intercrosses were harvested at various time points...
August 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28815136/design-recommendations-for-pharmacogenomics-clinical-decision-support-systems
#2
Maher Khelifi, Peter Tarczy-Hornoch, Emily B Devine, Wanda Pratt
The use of pharmacogenomics (PGx) in clinical practice still faces challenges to fully adopt genetic information in targeting drug therapy. To incorporate genetics into clinical practice, many support the use of Pharmacogenomics Clinical Decision Support Systems (PGx-CDS) for medication prescriptions. This support was fueled by new guidelines to incorporate genetics for optimizing drug dosage and reducing adverse events. In addition, the complexity of PGx led to exploring CDS outside the paradigm of the basic CDS tools embedded in commercial electronic health records...
2017: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/28815022/modeling-of-ras-complexes-supports-roles-in-cancer-for-less-studied-partners
#3
H Billur Engin, Daniel Carlin, Dexter Pratt, Hannah Carter
BACKGROUND: RAS protein interactions have predominantly been studied in the context of the RAF and PI3kinase oncogenic pathways. Structural modeling and X-ray crystallography have demonstrated that RAS isoforms bind to canonical downstream effector proteins in these pathways using the highly conserved switch I and II regions. Other non-canonical RAS protein interactions have been experimentally identified, however it is not clear whether these proteins also interact with RAS via the switch regions...
2017: BMC Biophysics
https://www.readbyqxmd.com/read/28813142/atomic-force-microscopy-infrared-spectroscopy-of-individual-atmospheric-aerosol-particles-sub-diffraction-limit-vibrational-spectroscopy-and-morphological-analysis
#4
Amy Lynne Bondy, Rachel M Kirpes, Rachel Leah Merzel, Kerri A Pratt, Mark M Banaszak Holl, Andrew P Ault
Chemical analysis of atmospheric aerosols is an analytical challenge, as aerosol particles are complex chemical mixtures that can contain hundreds to thousands of species in attoliter volumes at the most abundant sizes in the atmosphere (~100 nm). These particles have global impacts on climate and health, but there are few methods available that combine imaging and the detailed molecular information from vibrational spectroscopy for individual particles <500 nm. Herein, we show the first application of atomic force microscopy with infrared spectroscopy (AFM-IR) to detect trace organic and inorganic species and probe intraparticle chemical variation in individual particles down to 150 nm...
August 16, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28810452/structure-coercive-control-and-autonomy-promotion-a-comparison-of-fathers-and-mothers-food-parenting-strategies
#5
Mercedes Pratt, Debra Hoffmann, Maija Taylor, Dara Musher-Eizenman
This study explored differences in mothers' and fathers' food parenting strategies, specifically coercive control, structure, and autonomy promotion, and whether parenting style and parental responsibility for food parenting related to the use of these strategies. Parents of children aged 2.5-7.5 years ( N = 497) reported about their parenting practices and food parenting strategies. Parenting style accounted for the majority of the variance in food parenting. Fathers were more authoritarian than mothers...
May 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28793835/culturally-tailoring-a-patient-empowerment-and-diabetes-education-curriculum-for-the-african-american-church
#6
Eric Whitney, Elijah Kindred, Abdullah Pratt, Yolanda O'Neal, Rev Chauncey P Harrison, Monica E Peek
Purpose The African American church has long been recognized as a valuable partner for health interventions in the community. While an extensive literature exists documenting the potential efficacy of diabetes education programs in church settings, there has yet to be an effort to leverage spiritual beliefs and practices to promote diabetes self-management and shared decision making within a faith-based framework that is culturally tailored to the African American church. The purpose of this article is to describe the translation of a clinic-based diabetes education program into faith-based education curriculum tailored for use in the African American church...
August 1, 2017: Diabetes Educator
https://www.readbyqxmd.com/read/28790018/variation-in-single-nucleotide-sensitivity-of-eclip-derived-from-reverse-transcription-conditions
#7
REVIEW
Eric L Van Nostrand, Alexander Shishkin, Gabriel A Pratt, Thai B Nguyen, Gene W Yeo
Crosslinking and immunoprecipitation (CLIP) followed by high-throughput sequencing identifies the binding sites of RNA binding proteins on RNAs. The covalent RNA-amino acid adducts produced by UV irradiation can cause premature reverse transcription termination and deletions (referred to as crosslink-induced mutation sites (CIMS)), which may decrease overall cDNA yield but are exploited in state-of-the-art CLIP methods to identify these crosslink sites at single-nucleotide resolution. Here, we show the ratio of both crosslinked base deletions and read-through versus termination are highly dependent on the identity of the reverse transcriptase enzyme as well as on buffer conditions used...
August 5, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28782434/high-leptospira-seroprevalence-in-captive-and-wild-caught-vervet-monkeys-chlorocebus-sabeus-on-the-caribbean-island-of-saint-kitts
#8
Sreekumari Rajeev, Anne Conan, Nicola Pratt, Amy Beierschmitt, Roberta Palmour
Leptospirosis is a zoonotic disease of global importance. Very little information is available on Leptospira infection in nonhuman primates. We report herein a high seroprevalence (49.4%; 95% confidence interval: 41.6-57.2%) to Leptospira serovars in vervet monkeys ( Chlorocebus sabeus) on the Caribbean island of Saint Kitts. Monkeys bred in captivity ( n = 81) had a significantly higher seroprevalence compared to wild-caught monkeys ( n = 81; p < 0.05). Seroprevalence to serovar Bataviae was significantly higher in monkeys bred in captivity and was higher to serovar Bratislava in wild-caught monkeys ( p < 0...
August 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28778065/1-25d3-differentially-suppresses-bladder-cancer-cell-migration-and-invasion-through-the-induction-of-mir-101-3p
#9
Yingyu Ma, Wei Luo, Brittany L Bunch, Rachel N Pratt, Donald L Trump, Candace S Johnson
Metastasis is the major cause of bladder cancer death. 1,25D3, the active metabolite of vitamin D, has shown anti-metastasis activity in several cancer model systems. However, the role of 1,25D3 in migration and invasion in bladder cancer is unknown. To investigate whether 1,25D3 affects migration and invasion, four human bladder cell lines with different reported invasiveness were selected: low-invasive T24 and 253J cells and highly invasive 253J-BV and TCCSUP cells. All of the four bladder cancer cells express endogenous and inducible vitamin D receptor (VDR) as examined by immunoblot analysis...
July 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28777007/sink-or-collaborate-how-the-immersive-model-has-helped-address-typical-adolescent-and-young-adult-barriers-at-a-single-institution-and-kept-the-adolescent-and-young-adult-program-afloat
#10
Damon R Reed, Benjamin Oshrine, Christie Pratt, Olivia Fridgen, Cathy Elstner, Leila Wilson, Hatem Soliman, Marie C Lee, Howard L McLeod, Bijal Shah, Kristine A Donovan, Smitha Pabbathi, Mary Turney, Odion Binitie, Christine Healy, Michael Nieder, Peter H Shaw, Andrew Galligan, G Douglas Letson, Marilyn Stern, Gwendolyn P Quinn, Simon Davies
No abstract text is available yet for this article.
August 4, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28771876/i-was-yelled-at-intimidated-and-treated-unfairly-nursing-students-experiences-of-being-bullied-in-clinical-and-academic-settings
#11
Helen Courtney-Pratt, Jacqueline Pich, Tracy Levett-Jones, Annette Moxey
AIM: To present findings from a study that explored nursing students' experiences of bullying in clinical and academic settings, the strategies used to negotiate bullying, and recommendations for empowering future students. BACKGROUND: Nursing students are identified as a group who are at particular risk of bullying. Numerous studies have examined students' experiences of bullying in clinical contexts by qualified nurses, however, there has been far less attention to the bullying that occurs in academic settings where the perpetrators are university staff and other students...
August 3, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28767493/transgender-and-gender-nonconforming-patient-experiences-at-a-family-medicine-clinic
#12
Amanda Hinrichs, Carrie Link, Lea Seaquist, Peek Ehlinger, Stephanie Aldrin, Rebekah Pratt
PURPOSE: Transgender and gender nonconforming (TGNC) patients have a wide array of often negative experiences when accessing health care, and may encounter insensitive or subcompetent care; thus, the authors conducted a qualitative study with patients at one family medicine residency clinic to assess how primary care clinics can improve care for TGNC patients. METHOD: In 2015, the authors held three separate focus groups at Smiley's Family Medicine Clinic in Minneapolis, Minnesota...
August 1, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28766614/rotationally-resolved-electronic-spectroscopy-of-the-rotamers-of-1-3-dimethoxybenzene
#13
Michael Schneider, Martin Wilke, Marie-Luise Hebestreit, José Arturo Ruiz-Santoyo, Leonardo Álvarez-Valtierra, John T Yi, W Leo Meerts, David W Pratt, Michael Schmitt
Conformational assignments in molecular beam experiments are often based on relative energies, although there are many other relevant parameters, such as conformer-dependent oscillator strengths, Franck-Condon factors, quantum yields and vibronic couplings. In the present contribution, we investigate the conformational landscape of 1,3-dimethoxybenzene using a combination of rotationally resolved electronic spectroscopy and high level ab initio calculations. The electronic origin of one of the three possible planar rotamers (rotamer (0,180) with both substituents pointing at each other) has not been found...
August 16, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28766298/robust-cost-effective-profiling-of-rna-binding-protein-targets-with-single-end-enhanced-crosslinking-and-immunoprecipitation-seclip
#14
Eric L Van Nostrand, Thai B Nguyen, Chelsea Gelboin-Burkhart, Ruth Wang, Steven M Blue, Gabriel A Pratt, Ashley L Louie, Gene W Yeo
Profiling of RNA binding protein targets in vivo provides critical insights into the mechanistic roles they play in regulating RNA processing. The enhanced crosslinking and immunoprecipitation (eCLIP) methodology provides a framework for robust, reproducible identification of transcriptome-wide protein-RNA interactions, with dramatically improved efficiency over previous methods. Here we provide a step-by-step description of the eCLIP method, along with insights into optimal performance of critical steps in the protocol...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28760614/regulatory-considerations-in-development-of-vaccines-to-prevent-disease-caused-by-chikungunya-virus
#15
REVIEW
Sixun Yang, Doran Fink, Andrea Hulse, R Douglas Pratt
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus. Chikungunya disease (CHIK) in humans is characterized by sudden onset of high fever, cutaneous rash, myalgia and debilitating polyarthralgia. Until recently the virus was considered endemic to only Africa and Asia, but since 2004 CHIK has spread to previously non-endemic regions, including Europe and the Americas, thereby emerging as a global health threat. Although a variety of CHIKV vaccine candidates have been tested in animals, and a few have advanced to human clinical trials, no licensed vaccine is currently available for prevention of disease...
July 28, 2017: Vaccine
https://www.readbyqxmd.com/read/28754738/why-are-we-embarrassed-by-our-costs
#16
Adrian Pratt
No abstract text is available yet for this article.
July 29, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28750142/feline-leukocyte-adhesion-cd18-deficiency-caused-by-a-deletion-in-the-integrin-%C3%AE-2-itgb2-gene
#17
Thomas R Bauer, Suzanne M Pratt, Christina M Palena, Karthik Raj, Urs Giger
BACKGROUND: Leukocyte adhesion deficiency (LAD) or CD18 deficiency is an autosomal recessive immunodeficiency which has been described in people, cattle, dogs, and knockout mice. OBJECTIVES: The study goals were to characterize the clinicopathologic, immunologic, and molecular genetic features of feline LAD (FLAD) in a neutered male adult Domestic Longhair cat with severe leukocytosis and recurrent infections. METHODS: Flow cytometry evaluated surface expression of CD18 on neutrophils...
July 27, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28748143/successful-fluoroless-ablation-of-an-incessant-atypical-atrial-flutter-attributed-to-atriclip-usage-during-mini-maze-surgery-for-persistent-atrial-fibrillation
#18
Xiaoke Liu, Jerry Pratt, James Palmer
No abstract text is available yet for this article.
July 2017: HeartRhythm Case Reports
https://www.readbyqxmd.com/read/28741908/research-capacity-for-childhood-obesity-prevention-in-latin-america-an-area-for-growth
#19
Diana C Parra, Susan Vorkoper, Harold W Kohl, Benjamin Caballero, Carolina Batis, Alejandra Jauregui, Jessica Mason, Michael Pratt
BACKGROUND: The rise of childhood obesity in Latin America calls for research capacity to understand, monitor and implement strategies, policies and programmes to address it. OBJECTIVE: The objective of the study was to assess current research capacity in Latin America related to childhood obesity, nutrition and physical activity. METHODS: We conducted a search of peer-reviewed articles on childhood obesity in Latin America with at least one Latin American author from 2010 to May 2015...
July 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28741906/a-research-agenda-to-guide-progress-on-childhood-obesity-prevention-in-latin-america
#20
L Kline, J Jones-Smith, J Jaime Miranda, M Pratt, R S Reis, J A Rivera, J F Sallis, B M Popkin
Childhood obesity rates in Latin America are among the highest in the world. This paper examines and evaluates the many efforts underway in the region to reduce and prevent further increases in obesity, identifies and discusses unique research challenges and opportunities in Latin America, and proposes a research agenda in Latin America for the prevention of childhood obesity and concomitant non-communicable diseases. Identified research gaps include biological challenges to healthy growth across the life cycle, diet and physical activity dynamics, community interventions promoting healthy child growth, and rigorous evaluation of national food and activity programs and regulatory actions...
July 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
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