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https://www.readbyqxmd.com/read/28516333/risk-of-hip-fracture-in-older-people-using-selective-serotonin-reuptake-inhibitors-and-other-psychoactive-medicines-concurrently-a-matched-case-control-study-in-australia
#1
Michael J Leach, Nicole L Pratt, Elizabeth E Roughead
BACKGROUND: Few studies have assessed the risk of hip fracture following concurrent use of psychoactive medicines, and none has investigated combinations with selective serotonin reuptake inhibitors. OBJECTIVES: To assess the risk of hip fracture in older people as a result of concurrent use of selective serotonin reuptake inhibitors and other psychoactive medicines. METHODS: A matched case-control design was employed. Cases were Australian Government Department of Veterans' Affairs beneficiaries aged over 65 years who experienced a hip fracture between 2009 and 2012...
May 17, 2017: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/28513338/worldwide-surveillance-policy-and-research-on-physical-activity-and-health-the-global-observatory-for-physical-activity-gopa
#2
Andrea Ramirez Varela, Michael Pratt, Kenneth Powell, I-Min Lee, Adrian Bauman, Gregory Heath, Rafaela Costa Martins, Harold Kohl, Pedro C Hallal
BACKGROUND: The Global Observatory for Physical Activity-GoPA! was launched in response to the physical inactivity pandemic. The aim of this article is to present current information about surveillance, policy, and research on physical activity (PA) and health worldwide. METHODS: Information was collected for 217 countries. For 139 of these nations we identified a contact who confirmed information's accuracy and completeness. Associations were calculated among surveillance, policy and research categories...
May 17, 2017: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/28509715/epidemic-of-isothiazolinone-allergy-in-north-america-prevalence-data-from-the-north-american-contact-dermatitis-group-2013-2014
#3
Matthew J Zirwas, Dathan Hamann, Erin M Warshaw, Howard I Maibach, James S Taylor, Denis Sasseville, Joel G DeKoven, Anthony F Fransway, C G Toby Mathias, Kathryn A Zug, Vincent A DeLeo, Joseph F Fowler, James G Marks, Melanie D Pratt, Donald V Belsito
BACKGROUND: Preservative sensitivity patterns evolve with changing use patterns in products. During the last decade, the use of methylisothiazolinone (MI) at higher concentrations in both leave-on and rinse-off products has significantly increased. This is the first North American Contact Dermatitis Group reporting cycle that includes both methylchloroisothiazolinone (MCI)/MI and MI data. OBJECTIVE: The aim of this study was to report the prevalence of isothiazolinone allergy (MCI/MI and MI) in the North American Contact Dermatitis Group patch-test population from January 1, 2013, to December 31, 2014...
May 2017: Dermatitis
https://www.readbyqxmd.com/read/28509366/on-the-quality-of-adjustment-to-retirement-the-longitudinal-role-of-personality-traits-and-generativity
#4
Rodrigo Serrat, Feliciano Villar, Michael W Pratt, Arthur A Stukas
OBJECTIVE: Although psychological factors have been explored in relation to other life transitions, their influence on retirement adjustment quality has been largely overlooked. This study assessed the contribution of personality traits and generativity before retirement in the prediction of hedonic and eudaimonic wellbeing at two temporal points after retirement. METHOD: This article analyses data from the MIDUS (Midlife in the United States) longitudinal sample...
May 16, 2017: Journal of Personality
https://www.readbyqxmd.com/read/28508615/a-multidisciplinary-approach-to-puberty-and-fertility-in-girls-with-turner-syndrome
#5
Johanna Viau Colindres, Krista J Childress, Marni Axelrad, Laurence B McCullough, Yunru Shao, Charles Macias, Jennifer Loveless, Sheila K Gunn, Jennifer Bercaw-Pratt, Reid Sutton, Lefkothea P Karaviti, Jennifer E Dietrich
Women with Turner Syndrome (TS) have a variety of medical needs throughout their lives; however, the peripubertal years are particularly challenging. From a medical perspective, the burden of care increases during this time due to growth optimization strategies, frequent health screenings, and puberty induction. Psychologically, girls begin to comprehend the long-term implications of the condition, including their diminished fertility potential. Unfortunately, clear guidelines for how to best approach this stage have not been established...
September 2016: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28499343/knee-loading-deficits-during-dynamic-tasks-in-individuals-following-acl-reconstruction
#6
Kristamarie A Pratt, Susan M Sigward
Study Design Controlled laboratory study, cross-sectional. Background Well documented deficits in sagittal plane knee loading, during dynamic tasks indicate individuals limit the magnitude of knee loading following anterior cruciate ligament reconstruction (ACLR). It is unknown how these individuals modulate the speed of knee flexion during loading, which is particularly important as they progress to running during rehabilitation. Objective To investigate how individuals following anterior cruciate ligament reconstruction perform dynamic knee loading tasks compared to healthy controls...
May 12, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28496009/dynamic-changes-in-clonal-cytogenetic-architecture-during-progression-of-chronic-lymphocytic-leukemia-in-patients-and-patient-derived-murine-xenografts
#7
Nicholas J Davies, Marwan Kwok, Clive Gould, Ceri E Oldreive, Jingwen Mao, Helen Parry, Edward Smith, Angelo Agathanggelou, Guy Pratt, Alexander Malcolm R Taylor, Paul Moss, Mike Griffiths, Tatjana Stankovic
Subclonal heterogeneity and clonal selection influences disease progression in chronic lymphocytic leukemia (CLL). It is therefore important that therapeutic decisions are made based on an understanding of the CLL clonal architecture and its dynamics in individual patients. Identification of cytogenetic abnormalities by FISH remains the cornerstone of contemporary clinical practice and provides a simple means for prognostic stratification. Here, we demonstrate that multiplexed-FISH can enhance recognition of CLL subclonal repertoire and its dynamics during disease progression, both in patients and CLL patient-derived xenografts (PDX)...
April 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/28495793/usp7-inhibition-alters-homologous-recombination-repair-and-targets-cll-cells-independent-of-atm-p53-functional-status
#8
Angelo Agathanggelou, Edward Smith, Nicholas J Davies, Marwan Kwok, Anastasia Zlatanou, Ceri E Oldreive, Jingwen Mao, David Da Costa, Sina Yadollahi, Tracey Perry, Pamela Kearns, Anna Skowronska, Elliot Yates, Helen Parry, Peter Hillmen, Celine Reverdy, Remi Delansorne, Shankara Paneesha, Guy Pratt, Paul Moss, A Malcolm R Taylor, Grant S Stewart, Tatjana Stankovic
The role of the deubiquitylase ubiquitin-specific protease 7 (USP7) in the regulation of the p53-dependent DNA damage response (DDR) pathway is well established. Whilst previous studies have mostly focused on the mechanisms underlying how USP7 directly controls p53 stability, we have recently shown that USP7 modulates the stability of the DNA damage responsive E3 ubiquitin ligase, RAD18. This suggests that targeting USP7 may have therapeutic potential even in tumors with defective p53 or ibrutinib resistance...
May 11, 2017: Blood
https://www.readbyqxmd.com/read/28488302/the-big-d-eal-professional-identity-through-discursive-constructions-of-patient
#9
Brett Schrewe, Joanna Bates, Dan Pratt, Claudia W Ruitenberg, William H McKellin
CONTEXT: Professional identity formation has become a key focus for medical education. Who one becomes as a physician is contingent upon learning to conceptualise who the other is as a patient, yet, at a time when influential ideologies such as patient-centred care have become espoused values, there has been little empirical investigation into assumptions of 'patient' that trainees take up as they progress through their training. METHODS: Our team employed a critical discourse analysis approach to transcripts originally produced from a micro-ethnography of medical student learning on an acute care in-patient paediatric ward...
June 2017: Medical Education
https://www.readbyqxmd.com/read/28488253/increase-in-total-joint-arthroplasty-projected-from-2014-to-2046-in-australia-a-conservative-local-model-with-international-implications
#10
Maria C S Inacio, Stephen E Graves, Nicole L Pratt, Elizabeth E Roughead, Szilard Nemes
BACKGROUND: The incidence of joint arthroplasty is increasing worldwide. International estimates of future demand for joint arthroplasty have used models that propose either an exponential future increase, despite obvious system constraints, or static increases, which do not account for past trends. Country-specific projection estimates that address limitations of past projections are necessary. In Australia, a high-income country with the 7th highest incidence of TKA and 15th highest incidence of THA of the Organization for Economic Cooperation and Development (OECD) countries, the volume of TKAs and THAs increased 198% between 1994 and 2014...
May 9, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28487126/o-glcnac-modification-inhibits-the-calpain-mediated-cleavage-of-%C3%AE-synuclein
#11
Paul M Levine, Cesar A De Leon, Ana Galesic, Aaron Balana, Nicholas P Marotta, Yuka E Lewis, Matthew R Pratt
The major protein associated with Parkinson's disease (PD) is α-synuclein, as it can form toxic amyloid-aggregates that are a hallmark of many neurodegenerative diseases. α-Synuclein is a substrate for several different posttranslational modifications (PTMs) that have the potential to affect its biological functions and/or aggregation. However, the biophysical effects of many of these modifications remain to be established. One such modification is the addition of the monosaccharide N-acetyl-glucosamine, O-GlcNAc, which has been found on several α-synuclein serine and threonine residues in vivo...
April 29, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28476723/ethics-considerations-in-global-mobile-phone-based-surveys-of-noncommunicable-diseases-a-conceptual-exploration
#12
Joseph Ali, Alain B Labrique, Kara Gionfriddo, George Pariyo, Dustin G Gibson, Bridget Pratt, Molly Deutsch-Feldman, Adnan A Hyder
Mobile phone coverage has grown, particularly within low- and middle-income countries (LMICs), presenting an opportunity to augment routine health surveillance programs. Several LMICs and global health partners are seeking opportunities to launch basic mobile phone-based surveys of noncommunicable diseases (NCDs). The increasing use of such technology in LMICs brings forth a cluster of ethical challenges; however, much of the existing literature regarding the ethics of mobile or digital health focuses on the use of technologies in high-income countries and does not consider directly the specific ethical issues associated with the conduct of mobile phone surveys (MPS) for NCD risk factor surveillance in LMICs...
May 5, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28464660/pupillometry-shows-the-effort-of-auditory-attention-switching
#13
Daniel R McCloy, Bonnie K Lau, Eric Larson, Katherine A I Pratt, Adrian K C Lee
Successful speech communication often requires selective attention to a target stream amidst competing sounds, as well as the ability to switch attention among multiple interlocutors. However, auditory attention switching negatively affects both target detection accuracy and reaction time, suggesting that attention switches carry a cognitive cost. Pupillometry is one method of assessing mental effort or cognitive load. Two experiments were conducted to determine whether the effort associated with attention switches is detectable in the pupillary response...
April 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28456695/paratubal-cyst-size-correlates-with-obesity-and-dysregulation-of-the-wnt-signaling-pathway
#14
Jennifer E Dietrich, Oluyemisi Adeyemi, Julie Hakim, Xiomara Santos, Jennifer L Bercaw-Pratt, Juan C Bournat, Ching H Chen, Carolina J Jorgez
BACKGROUND: Paratubal cysts (PTC) occur in 7-10% of females, regardless of ages. Although common, PTCs often are found incidentally because of the potential for these cysts to be asymptomatic. SPECIFIC AIMS: To determine if PTC number and size correlated with signs of hyperandrogenism and obesity, as well as to investigate the molecular profiles of these PTCs in samples derived from adolescent females. METHODS: A prospective cohort study was performed in a single children's hospital...
April 26, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28449795/long-term-effect-of-endothelin-receptor-antagonism-with-bosentan-on-the-morbidity-and-mortality-of-patients-with-severe-chronic-heart-failure-primary-results-of-the-enable-trials
#15
Milton Packer, John J V McMurray, Henry Krum, Wolfgang Kiowski, Barry M Massie, Avi Caspi, Craig M Pratt, Mark C Petrie, David DeMets, Isaac Kobrin, Sebastien Roux, Karl Swedberg
OBJECTIVES: The objective of this clinical trial was to evaluate the long-term effect of endothelin receptor antagonism with bosentan on the morbidity and mortality of patients with severe chronic heart failure. BACKGROUND: Endothelin may play a role in heart failure, but short-term clinical trials with endothelin receptor antagonists have reported disappointing results. Long-term trials are lacking. METHODS: In 2 identical double-blind trials, we randomly assigned 1,613 patients with New York Heart Association functional class IIIb to IV heart failure and an ejection fraction <35% to receive placebo or bosentan (target dose 125 mg twice daily) for a median of 1...
May 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28446498/diet-quality-of-us-adolescents-during-the-transition-to-adulthood-changes-and-predictors
#16
Leah M Lipsky, Tonja R Nansel, Denise L Haynie, Danping Liu, Kaigang Li, Charlotte A Pratt, Ronald J Iannotti, Katherine W Dempster, Bruce Simons-Morton
Background: Influences on diet quality during the transition from adolescence to adulthood are understudied.Objective: This study examined association of 3 diet-quality indicators-Healthy Eating Index-2010 (HEI), Whole Plant Foods Density (WPF), and Empty Calories (EC; the percentage of calories from discretionary solid fat, added sugar and alcohol)-with lifestyle behaviors, baseline weight status, and sociodemographic characteristics in US emerging adults.Design: Data come from the first 4 waves (annual assessments) of the NEXT Plus Study, a population-based cohort of 10th graders enrolled in 2010 (n = 566)...
April 26, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28446455/the-economic-burden-of-physical-inactivity-a-systematic-review-and-critical-appraisal
#17
REVIEW
Ding Ding, Tracy Kolbe-Alexander, Binh Nguyen, Peter T Katzmarzyk, Michael Pratt, Kenny D Lawson
OBJECTIVE: To summarise the literature on the economic burden of physical inactivity in populations, with emphases on appraising the methodologies and providing recommendations for future studies. DESIGN: Systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PROSPERO registration number CRD42016047705). DATA SOURCES: Electronic databases for peer-reviewed and grey literature were systematically searched, followed by reference searching and consultation with experts...
April 26, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28432446/biasing-spatial-attention-with-semantic-information-an-event-coding-approach
#18
Tarek Amer, Davood G Gozli, Jay Pratt
We investigated the influence of conceptual processing on visual attention from the standpoint of Theory of Event Coding (TEC). The theory makes two predictions: first, an important factor in determining the influence of event 1 on processing event 2 is whether features of event 1 are bound into a unified representation (i.e., selection or retrieval of event 1). Second, whether processing the two events facilitates or interferes with each other should depend on the extent to which their constituent features overlap...
April 21, 2017: Psychological Research
https://www.readbyqxmd.com/read/28431816/role-of-controlled-human-malaria-infection-chmi-in-malaria-vaccine-development-a-u-s-food-drug-administration-fda-perspective
#19
Rana Chattopadhyay, Douglas Pratt
No abstract text is available yet for this article.
April 18, 2017: Vaccine
https://www.readbyqxmd.com/read/28431001/invasive-aspergillosis-in-patients-with-underlying-liver-cirrhosis-a-prospective-cohort-study
#20
Juergen Prattes, Martin Hoenigl, Robert Krause, Walter Buzina, Thomas Valentin, Frederike Reischies, Christoph Koidl, Ines Zollner-Schwetz
The aim of this study was to determine the prevalence of invasive aspergillosis (IA) in patients with liver cirrhosis and the performance of serum galactomannan (GM) screening. Patients with decompensated liver cirrhosis and patients with compensated liver cirrhosis presenting with fever and/or respiratory symptoms were prospectively enrolled. All patients were screened by serum GM twice weekly irrespective of clinical signs and symptoms. Positive serum GM triggered work-up consisting of chest computed tomography and in case of pathological findings bronchoscopy...
April 20, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
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