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https://www.readbyqxmd.com/read/29348251/reducing-cardiovascular-disparities-through-community-engaged-implementation-research-a-national-heart-lung-and-blood-institute-workshop-report
#1
George A Mensah, Richard S Cooper, Anna Maria Siega-Riz, Lisa A Cooper, Justin D Smith, C Hendricks Brown, John M Westfall, Elizabeth O Ofili, LeShawndra N Price, Sonia Arteaga, Melissa C Green Parker, Cheryl R Nelson, Bradley J Newsome, Nicole Redmond, Rebecca A Roper, Bettina M Beech, Jada L Brooks, Debra Furr-Holden, Samson Y Gebreab, Wayne H Giles, Regina Smith James, Tené T Lewis, Ali H Mokdad, Kari D Moore, Joseph E Ravenell, Al Richmond, Nancy E Schoenberg, Mario Sims, Gopal K Singh, Anne E Sumner, Roberto P Treviño, Karriem S Watson, M Larissa Avilés-Santa, Jared P Reis, Charlotte A Pratt, Michael M Engelgau, David C Goff, Eliseo J Pérez-Stable
Cardiovascular disparities remain pervasive in the United States. Unequal disease burden is evident among population groups based on sex, race, ethnicity, socioeconomic status, educational attainment, nativity, or geography. Despite the significant declines in cardiovascular disease mortality rates in all demographic groups during the last 50 years, large disparities remain by sex, race, ethnicity, and geography. Recent data from modeling studies, linked micromap plots, and small-area analyses also demonstrate prominent variation in cardiovascular disease mortality rates across states and counties, with an especially high disease burden in the southeastern United States and Appalachia...
January 19, 2018: Circulation Research
https://www.readbyqxmd.com/read/29345510/preliminary-evaluation-of-the-viability-of-peritoneal-drainage-catheters-implanted-in-rats-for-extended-durations
#2
Nathan Legband, Arielle Black, Craig Kreikemeier-Bower, Benjamin S Terry
Purpose/Aim: In developing a novel peritoneal oxygenation therapy, catheters implanted into the peritoneal cavity became obstructed with omental tissue and prevented the infusion and removal of fluid from the peritoneal cavity. The obstruction of peritoneal catheters is a significant failure in researching various peritoneal treatments as further fluid administration is no longer possible. The purpose of this preliminary study was to determine the most effective catheter design for infusion and removal of fluid into the peritoneal cavity of rats...
January 18, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29344696/reconstruction-of-the-medial-patellotibial-ligament-results-in-favorable-clinical-outcomes-a-systematic-review
#3
Charles A Baumann, Eli L Pratte, Seth L Sherman, Elizabeth A Arendt, Betina B Hinckel
PURPOSE: The medial patellotibial ligament (MPTL), the medial patellofemoral ligament (MPFL), and the medial patellomeniscal ligament (MPML) support the stability of the patellofemoral joint. The purpose of this systematic review was to report the surgical techniques and clinical outcomes of the repair or reconstruction of the MPTL in isolation or concomitant with the MPFL and/or other procedures. METHODS: A systematic review of the literature was conducted. Inclusion criteria were articles in the English language that reported clinical outcomes of the reconstruction of the MPTL in isolation or in combination with the MPFL and/or other procedures...
January 17, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29342358/synthesis-and-biological-characterization-of-aryl-uracil-inhibitors-of-hepatitis-c-virus-ns5b-polymerase-discovery-of-abt-072-a-trans-stilbene-analog-with-good-oral-bioavailability
#4
John Randolph, A Chris Krueger, Pamela Donner, John K Pratt, Dachun Liu, Christopher E Motter, Todd W Rockway, Mike D Tufano, Rolf Wagner, Hock B Lim, Jill M Beyer, Rubina Mondal, Neeta S Panchal, Lynn Colletti, Yaya Liu, Gennadiy Koev, Warren M Kati, Lisa E Hernandez, David W A Beno, Kenton L Longenecker, Kent D Stewart, Emily O Dumas, Akhteruzzaman Molla, Clarence Maring
ABT-072 is a non-nucleoside HCV NS5B polymerase inhibitor that was discovered as part of a program to identify new direct-acting antivirals (DAAs) for the treatment of HCV infection. This compound was identified during a medicinal chemistry effort to improve on an original lead, inhibitor 1, which we described in a previous publication. Replacement of the amide linkage in 1 with a trans-olefin resulted in improved compound permeability and solubility, and provided much better pharmacokinetic properties in preclinical species...
January 17, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29341265/cicatricial-alopecia-research-foundation-meeting-may-2016-progress-towards-the-diagnosis-treatment-and-cure-of-primary-cicatricial-alopecias
#5
John P Sundberg, Maria K Hordinsky, Wilma Bergfeld, Yolanda M Lenzy, Amy J McMichael, Angela M Christiano, Tracy McGregor, Kurt S Stenn, Raja K Sivamani, C Herbert Pratt, Lloyd E King
Primary Cicatricial Alopecias (PCAs) are a group of skin diseases in which there is progressive and permanent destruction of hair follicles followed by replacement with fibrous tissue. Unfortunately, by the time patients seek clinical evaluation of their hair loss, the skin is already inflamed and/or scarred, so there is little hope for a return to their normal hair growth pattern. Clinical and basic science investigations are now focusing on three forms of human PCA, lichen planopilaris (LPP), frontal fibrosing alopecia (FFA), and central centrifugal cicatricial alopecia (CCCA)...
January 16, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29340588/antimicrobial-resistant-klebsiella-pneumoniae-carriage-and-infection-in-specialized-geriatric-care-wards-linked-to-acquisition-in-the-referring-hospital
#6
Claire L Gorrie, Mirjana Mirceta, Ryan R Wick, Louise M Judd, Kelly L Wyres, Nicholas R Thomson, Richard A Strugnell, Nigel F Pratt, Jill S Garlick, Kerrie M Watson, Peter C Hunter, Steve A McGloughlin, Denis W Spelman, Adam W J Jenney, Kathryn E Holt
Background: Klebsiella pneumoniae is a leading cause of extended-spectrum beta-lactamase (ESBL) producing hospital-associated infections, for which elderly patients are at increased risk. Methods: We conducted a 1-year prospective cohort study, in which a third of patients admitted to two geriatric wards in a specialized hospital were recruited and screened for carriage of K. pneumoniae by microbiological culture. Clinical isolates were monitored via the hospital laboratory...
January 11, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29330680/the-illusion-of-control-sequential-dependencies-underlie-contingent-attentional-capture
#7
Greg Huffman, Victoria M Antinucci, Jay Pratt
The degree to which humans have top-down control over which information they process remains a central debate within the attention literature. Most of the evidence supporting the top-down control of visuospatial attention has come from cueing paradigms in which target stimuli are preceded by cues that are similar or dissimilar from the target. These studies find that the cues similar to targets capture attention, but dissimilar cues do not, suggesting the top-down control of attention. Here, we used a modified cueing paradigm to investigate an alternative possibility that the cue type differences are due to sequential dependency effects occurring between cue and target processing rather than the top-down control of attention...
January 12, 2018: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/29328357/sensitizing-inpatient-mental-health-staff-to-the-challenges-of-aging
#8
Michelle R Zechner, Joseph C Birkmann, Jennifer Sperduto, Carlos Pratt
Although the aging inpatient population in state psychiatric hospitals is growing significantly, there are few examples of available training to improve staff knowledge and practice. The current article describes a 10-week training series developed through a university and psychiatric hospital collaboration. Training was attended by 135 direct care nursing and rehabilitation staff and focused on improving aging awareness, problem solving, using person-centered therapeutic techniques, and engaging older adults...
January 11, 2018: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/29326776/aorto-right-ventricular-fistula-following-percutaneous-transcatheter-aortic-valve-replacement-case-report-and-literature-review
#9
Monoj K Konda, Jagadeesh K Kalavakunta, Jerry W Pratt, David Martin, Vishal Gupta
An 88-year-old woman with a prior history of aortic stenosis and history of valvuloplasty presented with worsening symptoms of heart failure and dizziness. She underwent successful transcatheter aortic valve replacement (TAVR) without complications. Follow-up echocardiograms revealed a small fistula connecting aorta to the right ventricle. The patient was initially asymptomatic but 3 months later developed overload of the right ventricle and heart failure and chose to continue medical therapy. She died of progressive heart failure at 9 months from onset of fistula...
October 2017: Heart Views: the Official Journal of the Gulf Heart Association
https://www.readbyqxmd.com/read/29323876/revolutionizing-our-understanding-of-amyloidogenic-proteins-by-cryo-electron-microscopy
#10
Paul M Levine, Matthew R Pratt
No abstract text is available yet for this article.
January 11, 2018: Biochemistry
https://www.readbyqxmd.com/read/29316189/acute-lumbar-paraspinal-compartment-syndrome-a-systematic-review
#11
REVIEW
William Alexander, Nelson Low, George Pratt
While still a rare entity, acute lumbar paraspinal compartment syndrome has an increasing incidence. Similar to other compartment syndromes, acute lumbar paraspinal compartment syndrome is defined by raised pressure within a closed fibro-osseous space, limiting tissue perfusion within that space. The resultant tissue ischaemia presents as acute pain, and if left untreated, it may result in permanent tissue damage. A literature search of 'paraspinal compartment syndrome' revealed 21 articles. The details from a case encountered by the authors are also included...
January 8, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29314498/design-of-aminobenzothiazole-inhibitors-of-rho-kinases-1-and-2-utilizing-pka-as-a-structure-surrogate
#12
Russell Judge, Victoria Scott, Gricelda Simler, Steve Pratt, Marian Namovic, Brent Putman, Ana Aguirre, Vincent Stoll, Mulugeta Mamo, Steve Swann, Adrian D Hobson
We describe the design, synthesis and SAR of a series of 2-aminobenzothiazole inhibitors of Rho Kinase (ROCK) 1 and 2 which were optimized to low nanomolar potencies using structure-based design. Protein Kinase A was used as a surrogate protein structure to guide compound design. A subset of these molecules also showed robust activity in a myosin phosphatase cell based assay and in a mechanical hyperalgesia in vivo pain model.
January 4, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29301973/association-between-hyperacute-stage-blood-pressure-variability-and-outcome-in-patients-with-spontaneous-intracerebral-hemorrhage
#13
Pil-Wook Chung, Joon-Tae Kim, Nerses Sanossian, Sidney Starkmann, Scott Hamilton, Jeffrey Gornbein, Robin Conwit, Marc Eckstein, Frank Pratt, Sam Stratton, David S Liebeskind, Jeffrey L Saver
BACKGROUND AND PURPOSE: Increased blood pressure (BP) variability, in addition to high BP, may contribute to adverse outcome in intracerebral hemorrhage. However, degree and association with outcome of BP variability (BPV) in the hyperacute period, 15 minutes to 5 hours after onset, have not been delineated. METHODS: Among consecutive patients with intracerebral hemorrhage enrolled in the FAST-MAG trial (Field Administration of Stroke Therapy-Magnesium), BPs were recorded by paramedics in the field and during the first 24 hours of hospital course...
January 4, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29298120/dissociating-orienting-biases-from-integration-effects-with-eye-movements
#14
Matthew D Hilchey, Jason Rajsic, Greg Huffman, Raymond M Klein, Jay Pratt
Despite decades of research, the conditions under which shifts of attention to prior target locations are facilitated or inhibited remain unknown. This ambiguity is a product of the popular feature discrimination task, in which attentional bias is commonly inferred from the efficiency by which a stimulus feature is discriminated after its location has been repeated or changed. Problematically, these tasks lead to integration effects; effects of target-location repetition appear to depend entirely on whether the target feature or response also repeats, allowing for several possible inferences about orienting bias...
January 1, 2018: Psychological Science
https://www.readbyqxmd.com/read/29287958/fragment-based-discovery-of-a-potent-nampt-inhibitor
#15
Alla Korepanova, Kenton L Longenecker, Steve D Pratt, Sanjay C Panchal, Richard F Clark, Marc Lake, Sujatha M Gopalakrishnan, Diana Raich, Chaohong Sun, Andrew M Petros
NAMPT expression is elevated in many cancers, making this protein a potential target for anticancer therapy. We have carried out both NMR based and TR-FRET based fragment screens against human NAMPT and identified six novel binders with a range of potencies. Co-crystal structures were obtained for two of the fragments bound to NAMPT while for the other four fragments force-field driven docking was employed to generate a bound pose. Based on structural insights arising from comparison of the bound fragment poses to that of bound FK866 we were able to synthetically elaborate one of the fragments into a potent NAMPT inhibitor...
December 12, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29284416/preoperative-medication-use-and-postoperative-delirium-a-systematic-review
#16
Gizat M Kassie, Tuan A Nguyen, Lisa M Kalisch Ellett, Nicole L Pratt, Elizabeth E Roughead
BACKGROUND: Medications are frequently reported as both predisposing factors and inducers of delirium. This review evaluated the available evidence and determined the magnitude of risk of postoperative delirium associated with preoperative medication use. METHODS: A systematic search in Medline and EMBASE was conducted using MeSH terms and keywords for postoperative delirium and medication. Studies which included patients 18 years and older who underwent major surgery were included...
December 29, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29280137/multi-site-investigation-of-strategies-for-the-implementation-of-cyp2c19-genotype-guided-antiplatelet-therapy
#17
Philip E Empey, James M Stevenson, Sony Tuteja, Kristin W Weitzel, Dominick J Angiolillo, Amber L Beitelshees, James C Coons, Julio D Duarte, Francesco Franchi, Linda J B Jeng, Julie A Johnson, Rolf P Kreutz, Nita A Limdi, Kristin A Maloney, Aniwaa Owusu Obeng, Josh F Peterson, Natasha Petry, Victoria M Pratt, Fabiana Rollini, Stuart A Scott, Todd C Skaar, Mark R Vesely, George A Stouffer, Russell A Wilke, Larisa H Cavallari, Craig R Lee
CYP2C19 genotype-guided antiplatelet therapy following percutaneous coronary intervention is increasingly implemented in clinical practice. However, challenges such as selecting a testing platform, communicating test results, building clinical decision support processes, providing patient and provider education, and integrating methods to support the translation of emerging evidence to clinical practice are barriers to broad adoption. In this report, we compare and contrast implementation strategies of 12 early adopters, describing solutions to common problems and initial performance metrics for each program...
December 26, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29279785/leptospira-seroprevalence-in-domestic-dogs-and-cats-on-the-caribbean-island-of-saint-kitts
#18
Nicola Pratt, Anne Conan, Sreekumari Rajeev
Leptospirosis is an important bacterial zoonotic disease that affects humans and many animal species. Knowledge of prevalence of Leptospira in a given geographic region supports the implementation of effective control/prevention programmes and thus reduces the transmission risks. This study provides Leptospira seroprevalence and serovar distribution in dogs and cats on the Caribbean island of Saint Kitts. Convenient serum samples from domestic dogs (n = 101) and cats (n = 50) were tested by the microscopic agglutination test (MAT) using 21 Leptospira serovars belonging to 17 serogroups...
2017: Veterinary Medicine International
https://www.readbyqxmd.com/read/29275829/risk-modeling-to-optimize-patient-selection-for-management-of-the-descending-thoracic-aortic-aneurysm
#19
Akiko Tanaka, Harleen K Sandhu, Wande B Pratt, Rana Afifi, Charles C Miller, Kristofer Charlton-Ouw, Maria E Codreanu, Naveed U Saqib, Ali Azizzadeh, Hazim J Safi, Anthony L Estrera
BACKGROUND: A single-institutional study comparing early and long-term outcomes of thoracic endovascular aortic repair (TEVAR) and open surgical repair (OSR) was performed to determine the appropriate treatment option for descending thoracic aortic aneurysm (DTAA). METHODS: Between 2005 and 2014, 438 DTAA patients were treated (TEVAR, 88; OSR, 350). Acute dissection and traumatic injury were excluded. Perioperative and follow-up data were reviewed. Stratified analyses were conducted to identify patients most likely to benefit from TEVAR...
December 21, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29274640/effectiveness-of-the-malnutrition-quality-improvement-initiative-on-practitioner-malnutrition-knowledge-and-screening-diagnosis-and-timeliness-of-malnutrition-related-care-provided-to-older-adults-admitted-to-a-tertiary-care-facility-a-pilot-study
#20
Heidi J Silver, Kelsey Jones Pratt, Michelle Bruno, Joe Lynch, Kristi Mitchell, Sharon M McCauley
BACKGROUND: Malnutrition is present in 30% to 50% of hospitalized patients aged 60 years or older. As few as 3.2% of patients identified as high risk have a malnutrition diagnosis documented by medical providers. The Malnutrition Quality Improvement Initiative (MQii) aims to reduce the burden of hospital malnutrition by improving the process and delivery of care. OBJECTIVE: To evaluate implementing the MQii toolkit of best practice resources for screening, diagnosis, documentation, and timeliness of malnutrition care...
January 2018: Journal of the Academy of Nutrition and Dietetics
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