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https://www.readbyqxmd.com/read/29765078/tdp-43-regulation-of-stress-granule-dynamics-in-neurodegenerative-disease-relevant-cell-types
#1
Yousra Khalfallah, Rachel Kuta, Camille Grasmuck, Alexandre Prat, Heather D Durham, Christine Vande Velde
Stress granules (SGs) are cytoplasmic foci that form in response to various external stimuli and are essential to cell survival following stress. SGs are studied in several diseases, including ALS and FTD, which involve the degeneration of motor and cortical neurons, respectively, and are now realized to be linked pathogenically by TDP-43, originally discovered as a component of ubiquitin-positive aggregates within patients' neurons and some glial cells. So far, studies to undercover the role of TDP-43 in SGs have used primarily transformed cell lines, and thus rely on the extrapolation of the mechanisms to cell types affected in ALS/FTD, potentially masking cell specific effects...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29763807/positional-scanning-library-applied-to-the-human-eosinophil-cationic-protein-rnase3-n-terminus-reveals-novel-and-potent-anti-biofilm-peptides
#2
David Pulido, Guillem Prats-Ejarque, Clara Villalba, Marcel Albacar, Mohammed Moussaoui, David Andreu, Rudolf Volkmer, Marc Torrent, Ester Boix
Eradication of established biofilm communities of pathogenic bacteria is one of the pending challenges in the development of new antimicrobial agents. In particular, the dreaded nosocomial Pseudomonas aeruginosa forms microbial communities that offer an enhanced resistance to conventional antibiotics. Recently, we have described an engineered antimicrobial peptide derived from the human RNase3, also named the eosinophil cationic protein (ECP), RN3 (5-36), which combines bactericidal activity with high cell agglutination and lipopolysaccharide (LPS) affinity...
May 8, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29763779/clinical-implications-of-the-non-luminal-intrinsic-subtypes-in-hormone-receptor-positive-breast-cancer
#3
REVIEW
Juan Miguel Cejalvo, Tomás Pascual, Aranzazu Fernández-Martínez, Fara Brasó-Maristany, Roger R Gomis, Charles M Perou, Montserrat Muñoz, Aleix Prat
Gene expression profiling has had a considerable impact on our understanding ofbreastcancer biology. Duringthelast decade, 4 intrinsic molecular subtypes of breast cancer (Luminal A, Luminal B, HER2-enriched [HER2-E] and Basal-like) have been identified and intensively studied. In this article, we review and discuss the clinical implications of the 2 non-luminal subtypes (i.e. HER2-E and Basal-like) identified within hormone receptor (HR)-positive disease. After reviewing 32 studies for a total of 13,091 samples, ∼8% and ∼ 15% of early and metastatic HR+/HER2-negative breast cancer, respectively, were found to be non-luminal...
May 7, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29757456/cancer-research-in-the-united-states-a-critical-review-of-current-status-and-proposal-for-alternative-models
#4
Hagop M Kantarjian, Ferran Prat, David P Steensma, Razelle Kurzrock, David J Stewart, Mikkael A Sekeres, Joseph Leveque
No abstract text is available yet for this article.
May 14, 2018: Cancer
https://www.readbyqxmd.com/read/29750275/endoscopic-endonasal-transclival-approach-to-the-ventral-brainstem-anatomic-study-of-the-safe-entry-zones-combining-fiber-dissection-technique-with-7-tesla-magnetic-resonance-guided-neuronavigation
#5
Alessandro Weiss, Paolo Perrini, Matteo De Notaris, Guadalupe Soria, Alarcon Carlos, Maura Castagna, Lodovico Lutzemberger, Orazio Santo Santonocito, Giuseppe Catapano, Amin Kassam, Alberto Prats Galino
BACKGROUND: Treatment of intrinsic lesions of the ventral brainstem is a surgical challenge that requires complex skull base antero- and posterolateral approaches. More recently, endoscopic endonasal transclival approach (EETA) has been reported in the treatment of selected ventral brainstem lesions. OBJECTIVE: In this study we explored the endoscopic ventral brainstem anatomy with the aim to describe the degree of exposure of the ventral safe entry zones. In addition, we used a newly developed method combining traditional white matter dissection with high-resolution 7T magnetic resonance imaging (MRI) of the same specimen coregistered using a neuronavigation system...
May 10, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29744645/reasons-for-delaying-surgery-following-hip-fractures-and-its-impact-on-one-year-mortality
#6
Alejandro Lizaur-Utrilla, Blanca Gonzalez-Navarro, Maria F Vizcaya-Moreno, Francisco A Miralles Muñoz, Santiago Gonzalez-Parreño, Fernando A Lopez-Prats
PURPOSE: The purposes of this study were to identify the reasons for delayed surgery following hip fractures and analyze the impact of these reasons on 1-year mortality. METHODS: A prospective cohort study of 1234 patients with mean age of 83.1 (range 65-92, SD 8.0) who underwent hip fracture surgery compared three subgroups: (1) surgery within two days from admission (609 patients); (2) delayed surgery for medical reasons (286); and (3) delayed surgery for organizational causes (339)...
May 9, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29742699/effect-of-photobiomodulation-treatment-in-the-sublingual-radial-artery-region-and-along-the-spinal-column-in-individuals-with-multiple-sclerosis-protocol-for-a-randomized-controlled-double-blind-clinical-trial
#7
RANDOMIZED CONTROLLED TRIAL
Tamiris da Silva, Fernanda Cordeiro da Silva, Andréa Oliver Gomes, Ariane Oliveira Viana, Marcela Letícia Leal Gonçalves, Maria Fernanda Setúbal Destro Rodrigues, Anna Carolina Ratto Tempestini Horliana, Daniela de Fátima Teixeira da Silva, Maria Cristina Chavantes, Yara Dadalti Fragoso, Luciana Prats Branco, Lara Jansiski Motta, Kristianne Porta Santos Fernandes, Raquel Agnelli Mesquita-Ferrari, Sandra Kalil Bussadori
BACKGROUND: Multiple sclerosis (MS) is an autoimmune disease, for which the forms of treatment are medication and rehabilitation. However, in vitro and in vivo studies have demonstrated that photobiomodulation can be an effective treatment modality for inflammatory diseases, including MS. Photobiomodulation has a broad range of benefits, such as the avoidance of cell and tissue death, the stimulation of healing and injury repair, reductions in pain, edema and inflammation, cell proliferation, and even apoptosis...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29742640/treatment-of-multidrug-resistant-tuberculosis-infection-in-children
#8
Andrea T Cruz, Anthony J Garcia-Prats, Jennifer Furin, James A Seddon
No abstract text is available yet for this article.
May 4, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29726023/the-determination-of-capreomycin-in-human-plasma-by-lc-ms-ms-using-ion-pairing-chromatography-and-solid-phase-extraction
#9
Blessings Thuboy, Tracy Kellermann, Sandra Castel, Jennifer Norman, Anton Joubert, Anthony J Garcia-Prats, Anneke C Hesseling, Lubbe Wiesner
A bioanalytical method was developed and validated for the quantification of Capreomycin (Cm) analogues, Cm IA and Cm IB, in human plasma. This implemented ion-pairing solid phase extraction (IP-SPE), followed by ion-pairing high performance liquid chromatography (IP-HPLC), with tandem mass spectrometry detection. Chromatographic separation was achieved using a Discovery C18, 5μm, 4.6 mm x 50 mm analytical column. An isocratic mobile phase consisting of water and acetonitrile with 0.1% formic acid and 4 mM Heptafluorobutyric acid (80,20; v/v), was used at a flow-rate of 500 μl per minute...
May 3, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29724856/rewiring-of-auxin-signaling-under-persistent-shade
#10
Ornella Pucciariello, Martina Legris, Cecilia Costigliolo Rojas, María José Iglesias, Carlos Esteban Hernando, Carlos Dezar, Martín Vazquez, Marcelo J Yanovsky, Scott A Finlayson, Salomé Prat, Jorge J Casal
Light cues from neighboring vegetation rapidly initiate plant shade-avoidance responses. Despite our detailed knowledge of the early steps of this response, the molecular events under prolonged shade are largely unclear. Here we show that persistent neighbor cues reinforce growth responses in addition to promoting auxin-responsive gene expression in Arabidopsis and soybean. However, while the elevation of auxin levels is well established as an early event, in Arabidopsis , the response to prolonged shade occurs when auxin levels have declined to the prestimulation values...
May 3, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29722466/post-procedural-lge-cmr-comparison-of-laser-and-radiofrequency-ablation-lesions-after-pulmonary-vein-isolation
#11
Rosa M Figueras I Ventura, Andrei D Mǎrgulescu, Eva M Benito, Francisco Alarcón, Norihiro Enomoto, Susanna Prat-Gonzalez, Rosario J Perea, Roger Borràs, Fredy Chipa, Elena Arbelo, Jose M Tolosana, Josep Brugada, Antonio Berruezo, Lluis Mont
INTRODUCTION: The purpose of this study was to compare the anatomical characteristics of scar formation achieved by visual guided laser balloon (Laser) and radiofrequency (RF) pulmonary vein isolation (PVI), using late-gadolinium-enhanced cardiac magnetic resonance imaging (LGE-CMR). METHODS AND RESULTS: We included 17 patients with paroxysmal or early persistent drug resistant AF who underwent Laser ablation; 2 were excluded due to procedure-related complications...
May 3, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29720850/diagnosis-and-treatment-of-superficial-esophageal-cancer
#12
REVIEW
Maximilien Barret, Frédéric Prat
Endoscopy allows for the screening, early diagnosis, treatment and follow up of superficial esophageal cancer. Endoscopic submucosal dissection has become the gold standard for the resection of superficial squamous cell neoplasia. Combinations of endoscopic mucosal resection and radiofrequency ablation are the mainstay of the management of Barrett's associated neoplasia. However, protruded, non-lifting or large lesions may be better managed by endoscopic submucosal dissection. Novel ablation tools, such as argon plasma coagulation with submucosal lifting and cryoablation balloons, are being developed for the treatment of residual Barrett's esophagus, since iatrogenic strictures still hamper the development of extensive circumferential resections in the esophagus...
May 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29717694/vaccines-trust-and-european-public-health
#13
Andrea Ammon, Xavier Prats Monné
No abstract text is available yet for this article.
April 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29712965/head-to-head-comparison-of-two-engineered-cardiac-grafts-for-myocardial-repair-from-scaffold-characterization-to-pre-clinical-testing
#14
Isaac Perea-Gil, Carolina Gálvez-Montón, Cristina Prat-Vidal, Ignasi Jorba, Cristina Segú-Vergés, Santiago Roura, Carolina Soler-Botija, Oriol Iborra-Egea, Elena Revuelta-López, Marco A Fernández, Ramon Farré, Daniel Navajas, Antoni Bayes-Genis
Cardiac tissue engineering, which combines cells and supportive scaffolds, is an emerging treatment for restoring cardiac function after myocardial infarction (MI), although, the optimal construct remains a challenge. We developed two engineered cardiac grafts, based on decellularized scaffolds from myocardial and pericardial tissues and repopulated them with adipose tissue mesenchymal stem cells (ATMSCs). The structure, macromechanical and micromechanical scaffold properties were preserved upon the decellularization and recellularization processes, except for recellularized myocardium micromechanics that was ∼2-fold stiffer than native tissue and decellularized scaffolds...
April 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29703984/author-correction-unravelling-the-effects-of-mechanical-physiological-conditioning-on-cardiac-adipose-tissue-derived-progenitor-cells-in-vitro-and-in-silico
#15
Aida Llucià-Valldeperas, Ramon Bragós, Carolina Soler-Botija, Santiago Roura, Carolina Gálvez-Montón, Cristina Prat-Vidal, Isaac Perea-Gil, Antoni Bayes-Genis
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
April 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29703707/reliability-of-hiv-rapid-diagnostic-tests-for-self-testing-compared-with-testing-by-health-care-workers-a-systematic-review-and-meta-analysis
#16
Carmen Figueroa, Cheryl Johnson, Nathan Ford, Anita Sands, Shona Dalal, Robyn Meurant, Irena Prat, Karin Hatzold, Willy Urassa, Rachel Baggaley
BACKGROUND: The ability of individuals to use HIV self-tests correctly is debated. To inform the 2016 WHO recommendation on HIV self-testing, we assessed the reliability and performance of HIV rapid diagnostic tests when used by self-testers. METHODS: In this systematic review and meta-analysis, we searched PubMed, PopLine, and Embase, conference abstracts, and additional grey literature between Jan 1, 1995, and April 30, 2016, for observational and experimental studies reporting on HIV self-testing performance...
April 24, 2018: Lancet HIV
https://www.readbyqxmd.com/read/29699891/electrohysterographic-characterization-of-the-uterine-myoelectrical-response-to-labor-induction-drugs
#17
Carlos Benalcazar-Parra, Yiyao Ye-Lin, Javier Garcia-Casado, Rogelio Monfort-Orti, Jose Alberola-Rubio, Alfredo Perales, Gema Prats-Boluda
Labor induction is a common practice to promote uterine contractions and labor onset. Uterine electrohysterogram (EHG) has proved its suitability for characterizing the uterus electrophysiological condition in women with spontaneous labor. The aim of this study was to characterize and compare uterine myoelectrical activity during the first 4 h in response to labor induction drugs, Misoprostol (G1) and Dinoprostone (G2), by analyzing the differences between women who achieved active phase of labor and those who did not (successful and failed inductions)...
April 23, 2018: Medical Engineering & Physics
https://www.readbyqxmd.com/read/29697741/non-epithelial-ovarian-cancer-esmo-clinical-practice-guidelines-for-diagnosis-treatment-and-follow-up
#18
I Ray-Coquard, P Morice, D Lorusso, J Prat, A Oaknin, P Pautier, N Colombo
No abstract text is available yet for this article.
April 25, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29691173/cruciate-retaining-vs-posterior-stabilized-primary-total-arthroplasty-clinical-outcome-comparison-with-a-minimum-follow-up-of-10-years
#19
Ricardo Serna-Berna, Alejandro Lizaur-Utrilla, Maria F Vizcaya-Moreno, Francisco A Miralles Muñoz, Blanca Gonzalez-Navarro, Fernando A Lopez-Prats
BACKGROUND: Controversy continues regarding whether the posterior cruciate ligament should be retained or removed during total knee arthroplasty (TKA) procedure. The objective was to compare the clinical outcomes with a minimum follow-up of 10 years between patients who received contemporary cruciate-retaining or posterior-stabilized primary TKA. METHODS: Case-control study of 268 patients who underwent cruciate-retaining TKA vs 211 to posterior-stabilized design, with the same arthroplasty system, and a minimum follow-up of 10 years...
March 17, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29685294/epstein-barr-virus-associated-immune-reconstitution-inflammatory-syndrome-as-possible-cause-of-fulminant-multiple-sclerosis-relapse-after-natalizumab-interruption
#20
Barbara Serafini, Stephanie Zandee, Barbara Rosicarelli, Eleonora Scorsi, Caterina Veroni, Catherine Larochelle, Sandra D'Alfonso, Alexandre Prat, Francesca Aloisi
No abstract text is available yet for this article.
June 15, 2018: Journal of Neuroimmunology
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