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https://www.readbyqxmd.com/read/28502871/a-leadless-pacemaker-in-the-real-world-setting-the-micra-transcatheter-pacing-system-post-approval-registry
#1
Paul R Roberts, Nicolas Clementy, Faisal Al Samadi, Christophe Garweg, Jose Luis Martinez-Sande, Saverio Iacopino, Jens Brock Johansen, Xavier Vinolas Prat, Robert Kowal, Didier Klug, Lluis Mont, Jan Steffel, Shelby Li, Dirk Van Osch, Mikhael F El-Chami
BACKGROUND: First-in-man studies of leadless pacemakers have demonstrated high implant success rates, and safety and efficacy objectives were achieved. Outside of the investigational setting, there are particular concerns over cardiac effusion/perforation, device dislodgement, infection, telemetry, and battery issues. OBJECTIVE: The acute performance of the Micra transcatheter pacemaker from a worldwide post-approval registry is reported. METHODS: The registry is an ongoing prospective single-arm observational study designed to assess the safety and effectiveness of Micra in the post-approval setting...
May 11, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28502757/the-placental-imprinted-dlk1-dio3-domain-a-new-link-to-pre-and-postnatal-growth-in-humans
#2
Anna Prats-Puig, Gemma Carreras-Badosa, Judit Bassols, Patricia Cavelier, Agnés Magret, Cristina Sabench, Francis de Zegher, Lourdes Ibáñez, Robert Feil, Abel López-Bermejo
BACKGROUND: The developmentally important DLK1-DIO3 imprinted domain on human chromosome 14 is regulated by two differentially methylated regions(DMRs), the IG-DMR and the MEG3 DMR. OBJECTIVES: The aim was to determine the natural variation in DNA methylation at these DMRs in human placentas, and to determine its link to gene expression levels at the domain. Second, to explore whether the domain's methylation and gene expression correlate with pre- and early-postnatal growth of the conceptus...
May 11, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28502639/too-much-ophthalmology-ophthalmology-in-the-era-of-over-diagnosis-and-over-treatment
#3
R Vallès Fernández, J González Martín-Moro, N Prat Gil, J M Bonet Simó, D Mingo-Botín
No abstract text is available yet for this article.
May 11, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28499481/-supporting-the-parental-function-in-the-case-of-child-placement
#4
Annie Prat
When a child is placed in care, it is important that the parents' access visit can take place in an environment which helps to support the parental function. Time remains a major component which professionals must understand in order to support the children and their parents along this long pathway. This article presents the experience of the Diapason service, a meeting place for parents of children in care.
May 2017: Soins. Pédiatrie, Puériculture
https://www.readbyqxmd.com/read/28499274/api5-a-new-cofactor-of-estrogen-receptor-alpha-involved-in-breast-cancer-outcome
#5
Céline Basset, Florence Bonnet-Magnaval, Marina Garcia-Jove Navarro, Christian Touriol, Monique Courtade, Hervé Prats, Barbara Garmy-Susini, Eric Lacazette
Api5 (Apoptosis inhibitor 5) is an anti-apoptotic factor that confers resistance to genotoxic stress in human cancer. Api5 is also expressed in endothelial cells and participates to the Estrogen Receptor α (ERα) signaling to promote cell migration. In this study, we found an over expression of Api5 in human breast cancer. Given that we show that high expression of Api5 in breast cancer patients is associated with shorter recurrence free survival, we investigated the relationship between ERα and Api5 at the molecular level...
April 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28498710/charge-induced-force-noise-on-free-falling-test-masses-results-from-lisa-pathfinder
#6
M Armano, H Audley, G Auger, J T Baird, P Binetruy, M Born, D Bortoluzzi, N Brandt, A Bursi, M Caleno, A Cavalleri, A Cesarini, M Cruise, K Danzmann, M de Deus Silva, I Diepholz, R Dolesi, N Dunbar, L Ferraioli, V Ferroni, E D Fitzsimons, R Flatscher, M Freschi, J Gallegos, C García Marirrodriga, R Gerndt, L Gesa, F Gibert, D Giardini, R Giusteri, C Grimani, J Grzymisch, I Harrison, G Heinzel, M Hewitson, D Hollington, M Hueller, J Huesler, H Inchauspé, O Jennrich, P Jetzer, B Johlander, N Karnesis, B Kaune, C J Killow, N Korsakova, I Lloro, L Liu, J P López-Zaragoza, R Maarschalkerweerd, S Madden, D Mance, V Martín, L Martin-Polo, J Martino, F Martin-Porqueras, I Mateos, P W McNamara, J Mendes, L Mendes, A Moroni, M Nofrarias, S Paczkowski, M Perreur-Lloyd, A Petiteau, P Pivato, E Plagnol, P Prat, U Ragnit, J Ramos-Castro, J Reiche, J A Romera Perez, D I Robertson, H Rozemeijer, F Rivas, G Russano, P Sarra, A Schleicher, J Slutsky, C Sopuerta, T J Sumner, D Texier, J I Thorpe, C Trenkel, D Vetrugno, S Vitale, G Wanner, H Ward, P J Wass, D Wealthy, W J Weber, A Wittchen, C Zanoni, T Ziegler, P Zweifel
We report on electrostatic measurements made on board the European Space Agency mission LISA Pathfinder. Detailed measurements of the charge-induced electrostatic forces exerted on free-falling test masses (TMs) inside the capacitive gravitational reference sensor are the first made in a relevant environment for a space-based gravitational wave detector. Employing a combination of charge control and electric-field compensation, we show that the level of charge-induced acceleration noise on a single TM can be maintained at a level close to 1...
April 28, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28498284/undifferentiated-and-dedifferentiated-endometrial-carcinomas-with-pole-exonuclease-domain-mutations-have-a-favorable-prognosis
#7
Iñigo Espinosa, Cheng-Han Lee, Emanuela D'Angelo, José Palacios, Jaime Prat
POLE exonuclease domain mutations have recently been described in undifferentiated endometrial carcinoma but, because of the rarity of this aggressive type of endometrial cancer, their prognostic significance is unknown. We have analyzed the immunophenotype (ARID1A, MLH1, PMS2, MSH2, MSH6, p53, β-catenin, and SMARCB1) and mutational status (POLE, PIK3CA, and PTEN) of 21 undifferentiated carcinomas (8 undifferentiated and 13 dedifferentiated carcinomas). Loss of ARID1A expression was observed in 9 of 19 cases (47%), loss of expression of at least 1 DNA mismatch repair protein in 7 (7/21; 33%), and p53 immunoreaction was aberrant (mutated/inactivated) in 11 cases (11/21; 52%)...
May 11, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28498025/understanding-meaning-in-life-interventions-in-patients-with-advanced-disease-a-systematic-review-and-realist-synthesis
#8
Mariona Guerrero-Torrelles, Cristina Monforte-Royo, Andrea Rodríguez-Prat, Josep Porta-Sales, Albert Balaguer
BACKGROUND: Among patients with advanced disease, meaning in life is thought to enhance well-being, promote coping and improve the tolerance of physical symptoms. It may also act as a buffer against depression and hopelessness. As yet, there has been no synthesis of meaning in life interventions in which contextual factors, procedures and outcomes are described and evaluated. AIMS: To identify meaning in life interventions implemented in patients with advanced disease and to describe their context, mechanisms and outcomes...
February 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/28495878/local-amplifiers-of-il-4r%C3%AE-mediated-macrophage-activation-promote-repair-in-lung-and-liver
#9
Carlos M Minutti, Lucy H Jackson-Jones, Belén García-Fojeda, Johanna A Knipper, Tara E Sutherland, Nicola Logan, Emma Rinqvist, Raquel Guillamat-Prats, David A Ferenbach, Antonio Artigas, Cordula Stamme, Zissis C Chroneos, Dietmar M Zaiss, Cristina Casals, Judith E Allen
The type 2 immune response controls helminth infection and maintains tissue homeostasis but can lead to allergy and fibrosis if not adequately regulated. We have discovered local tissue-specific amplifiers of type-2 mediated-macrophage activation. In the lung, surfactant protein A (SP-A) enhanced IL-4-dependent macrophage proliferation and activation, accelerating parasite clearance and reducing pulmonary injury following infection with a lung-migrating helminth. In the peritoneal cavity and liver, C1q enhancement of type 2 macrophage activation was required for liver repair following bacterial infection, but resulted in fibrosis following peritoneal dialysis...
May 11, 2017: Science
https://www.readbyqxmd.com/read/28494996/prediction-of-labor-onset-type-spontaneous-vs-induced-role-of-electrohysterography
#10
Jose Alberola-Rubio, Javier Garcia-Casado, Gema Prats-Boluda, Yiyao Ye-Lin, Domingo Desantes, Javier Valero, Alfredo Perales
BACKGROUND AND OBJECTIVE: Induction of labor (IOL) is a medical procedure used to initiate uterine contractions to achieve delivery. IOL entails medical risks and has a significant impact on both the mother's and newborn's well-being. The assistance provided by an automatic system to help distinguish patients that will achieve labor spontaneously from those that will need late-term IOL would help clinicians and mothers to take an informed decision about prolonging pregnancy. With this aim, we developed and evaluated predictive models using not only traditional obstetrical data but also electrophysiological parameters derived from the electrohysterogram (EHG)...
June 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28487385/immune-related-gene-expression-profiling-after-pd-1-blockade-in-non-small-cell-lung-carcinoma-head-and-neck-squamous-cell-carcinoma-and-melanoma
#11
Aleix Prat, Alejandro Navarro, Laia Paré, Noemí Reguart, Patricia Galvan, Tomás Pascual, Alex Martínez, Paolo Nuciforo, Laura Comerma, Llucia Alos, Nuria Pardo, Susana Cedrés, Cheng Fan, Joel S Parker, Lydia Gaba, Ivan Victoria, Nuria Viñolas, Ana Vivancos, Ana Arance, Enriqueta Felip
Antibody targeting of the immune checkpoint receptor PD1 produces therapeutic activity in a variety of solid tumors, but most patients exhibit partial or complete resistance to treatment for reasons that are unclear. In this study, we evaluated tumor speciments from 65 patients with melanoma, lung non-squamous, squamous cell lung or head and neck cancers who were treated with the approved PD1 targeting antibodies pembrolizumab or nivolumab. Tumor RNA before anti-PD1 therapy was analyzed on the nCounter system using the PanCancer 730-Immune Panel, and we identified 23 immune-related genes or signatures linked to response and progression-free survival (PFS)...
May 9, 2017: Cancer Research
https://www.readbyqxmd.com/read/28486961/role-of-heparin-in-pulmonary-cell-populations-in-an-in-vitro-model-of-acute-lung-injury
#12
Marta Camprubí-Rimblas, Raquel Guillamat-Prats, Thomas Lebouvier, Josep Bringué, Laura Chimenti, Manuela Iglesias, Carme Obiols, Jessica Tijero, Lluís Blanch, Antonio Artigas
BACKGROUND: In the early stages of acute respiratory distress syndrome (ARDS), pro-inflammatory mediators inhibit natural anticoagulant factors and initiate an increase in procoagulant activity. Previous studies proved the beneficial effects of heparin in pulmonary coagulopathy, which derive from its anticoagulant and anti-inflammatory activities, although it is uncertain whether heparin works. Understanding the specific effect of unfractioned heparin on cell lung populations would be of interest to increase our knowledge about heparin pathways and to treat ARDS...
May 10, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28482036/stability-of-second-line-tuberculosis-medications-mixed-with-milk-or-yogurt
#13
Elizabeth P Harausz, Jessica Leigh, Anthony J Garcia-Prats, Jennifer Furin, Charles A Peloquin
No abstract text is available yet for this article.
May 6, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28479187/brain-based-individual-difference-measures-of-reading-skill-in-deaf-and-hearing-adults
#14
Alison S Mehravari, Karen Emmorey, Chantel S Prat, Lindsay Klarman, Lee Osterhout
Most deaf children and adults struggle to read, but some deaf individuals do become highly proficient readers. There is disagreement about the specific causes of reading difficulty in the deaf population, and consequently, disagreement about the effectiveness of different strategies for teaching reading to deaf children. Much of the disagreement surrounds the question of whether deaf children read in similar or different ways as hearing children. In this study, we begin to answer this question by using real-time measures of neural language processing to assess if deaf and hearing adults read proficiently in similar or different ways...
May 4, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28479042/baseline-characteristics-and-outcomes-after-transcatheter-aortic-valve-implantation-in-patients-with-or-without-previous-balloon-aortic-valvuloplasty-insights-from-the-france-2-registry
#15
Loïc Bière, Amélie Durfort, Olivier Fouquet, Jean-François Hamel, Pascal Leprince, Karine Chevreul, Alain Prat, Michel Lievre, Patrick Donzeau-Gouge, Jean Fajadet, Emmanuel Teiger, Hélène Eltchaninoff, Bernard Iung, Alain Leguerrier, Martine Gilard, Alain Furber
BACKGROUND: Some patients who are at high surgical risk because of multiple co-morbidities undergo balloon aortic valvuloplasty (BAV) as a bridge therapy towards transcatheter aortic-valve implantation (TAVI). AIM: The aim of this study was to compare the clinical course of patients with or without previous BAV who underwent TAVI and were included in the FRANCE 2 registry. METHODS: From January 2010 to December 2011, 3953 patients underwent TAVI...
May 3, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28476289/statin-associated-muscle-symptoms-beware-of-the-nocebo-effect
#16
Juan Pedro-Botet, Juan Rubiés-Prat
No abstract text is available yet for this article.
May 2, 2017: Lancet
https://www.readbyqxmd.com/read/28475885/proteostatic-and-metabolic-control-of-stemness
#17
REVIEW
Laura García-Prat, Pedro Sousa-Victor, Pura Muñoz-Cánoves
Adult stem cells, particularly those resident in tissues with little turnover, are largely quiescent and only activate in response to regenerative demands, while embryonic stem cells continuously replicate, suggesting profoundly different regulatory mechanisms within distinct stem cell types. In recent years, evidence linking metabolism, mitochondrial dynamics, and protein homeostasis (proteostasis) as fundamental regulators of stem cell function has emerged. Here, we discuss new insights into how these networks control potency, self-renewal, differentiation, and aging of highly proliferative embryonic stem cells and quiescent adult stem cells, with a focus on hematopoietic and muscle stem cells and implications for anti-aging research...
May 4, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28468879/regulation-of-tacaribe-mammarenavirus-translation-positive-5-and-negative-3-elements-and-role-of-key-cellular-factors
#18
Sabrina Foscaldi, Alejandra D'Antuono, María Gabriela Noval, Gonzalo de Prat Gay, Luis Scolaro, Nora Lopez
Mammarenaviruses are enveloped viruses with a bisegmented negative-stranded RNA genome that encodes the nucleocapsid protein (NP), the envelope glycoprotein precursor (GPC), the RNA polymerase (L), and a RING matrix protein (Z). Viral proteins are synthesized from subgenomic messenger RNAs bearing a capped 5' untranslated region (UTR), and lacking 3' poly(A) tail. We analyzed the translation strategy of Tacaribe virus (TCRV), a prototype of the New World mammarenaviruses. A virus-like transcript that carries a reporter gene in place of the NP open-reading frame as well as transcripts bearing modified 5' and/or 3' UTRs were evaluated in a cell-based translation assay...
May 3, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28468828/thrombin-activation-of-protein-c-requires-prior-processing-by-a-liver-proprotein-convertase
#19
Rachid Essalmani, Delia Susan-Resiga, Johann Guillemot, Kim WooJin, Vatsal Sachan, Zuhier Awan, Ann Chamberland, Marie-Claude Asselin, Kévin Ly, Roxanne Desjardins, Robert Day, Annik Prat, Nabil G Seidah
Protein C, a secretory vitamin K-dependent anticoagulant serine protease, inactivates factors Va/VIIIa. It is exclusively synthesized in liver hepatocytes as an inactive zymogen (proProtein C). In human, thrombin cleavage of the propeptide at PR221↓ results in activated Protein C (APC; residues 222-461). However, the propeptide is also cleaved by a furin-like proprotein convertase(s) at KKRSHLKR199↓, but the order of cleavage is unknown. Herein, we present evidence that at the cell surface of Cos-1 cells, mouse proProtein C is first cleaved by the convertases furin, PC5/6A and PACE4...
May 3, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28464200/submucosal-tunneling-endoscopic-septum-division-for-zenker-s-diverticulum-a-reproducible-procedure-for-endoscopists-who-perform-peroral-endoscopic-myotomy
#20
Bertrand Brieau, Sarah Leblanc, Benoit Bordacahar, Maximillien Barret, Romain Coriat, Frederic Prat, Stanislas Chaussade
No abstract text is available yet for this article.
May 2, 2017: Endoscopy
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