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https://www.readbyqxmd.com/read/28434413/drug-evaluation-and-decision-making-in-catalonia-development-and-validation-of-a-methodological-framework-based-on-multi-criteria-decision-analysis-mcda-for-orphan-drugs
#1
Antoni Gilabert-Perramon, Josep Torrent-Farnell, Arancha Catalan, Alba Prat, Manel Fontanet, Ruth Puig-Peiró, Sandra Merino-Montero, Hanane Khoury, Mireille M Goetghebeur, Xavier Badia
OBJECTIVES: The aim of this study was to adapt and assess the value of a Multi-Criteria Decision Analysis (MCDA) framework (EVIDEM) for the evaluation of Orphan drugs in Catalonia (Catalan Health Service). METHODS: The standard evaluation and decision-making procedures of CatSalut were compared with the EVIDEM methodology and contents. The EVIDEM framework was adapted to the Catalan context, focusing on the evaluation of Orphan drugs (PASFTAC program), during a Workshop with sixteen PASFTAC members...
April 24, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28431051/safety-long-term-outcomes-and-predictors-of-recurrence-after-first-line-combined-endoepicardial-ventricular-tachycardia-substrate-ablation-in-arrhythmogenic-cardiomyopathy-impact-of-arrhythmic-substrate-distribution-pattern-a-prospective-multicentre-study
#2
Antonio Berruezo, Juan Acosta, Juan Fernández-Armenta, Alonso Pedrote, Alberto Barrera, Eduardo Arana-Rueda, Andrés Ignacio Bodegas, Ignasi Anguera, Luis Tercedor, Diego Penela, David Andreu, Rosario Jesus Perea, Susana Prat-González, Lluis Mont
Background: First-line endoepicardial ventricular tachycardia (VT) ablation has been proposed for patients with arrhythmogenic cardiomyopathy (AC). This study reports procedural safety, outcomes, and predictors of recurrence. Methods and Results: Forty-one consecutive patients [12 with left ventricle (LV) involvement, 7 left-dominant] underwent first-line endoepicardial VT substrate ablation. Standard bipolar and unipolar thresholds were used to define low-voltage areas (LVA)...
April 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28430721/outcomes-of-reverse-total-shoulder-arthroplasty-for-proximal-humeral-fractures-primary-arthroplasty-versus-secondary-arthroplasty-following-failed-proximal-humeral-locking-plate-fixation
#3
Emilio Sebastia-Forcada, Alejandro Lizaur-Utrilla, Román Cebrian-Gomez, Francisco A Miralles-Muñoz, Fernando A Lopez-Prats
OBJECTIVE: To compare the outcomes of reverse shoulder arthroplasty (RSA) between patients with failed proximal humeral locking plate (PHLP) fixation and those with acute fractures. DESIGN: Matched case-control study. SETTING: University hospital, level I trauma center. PATIENTS: 30 consecutive patients with fracture sequelae due to failed PHLP fixation (mean age 73) were age- and gender-matched to 30 patients with acute fracture (mean age 75)...
April 6, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28429028/experimental-separation-steps-influence-the-protein-content-of-corona-around-mesoporous-silica-nanoparticles
#4
C Pisani, J C Gaillard, C Dorandeu, C Charnay, Y Guari, J Chopineau, J M Devoisselle, J Armengaud, O Prat
In order to direct nanocarriers to their targets efficiently, we have to understand the interactions occurring at the nano-bio interface between nanocarriers and human proteins, which forms the layer called the corona. However, experiments aiming to identify and quantify the proteins in the corona, especially critical steps in the separation of nanoparticles from biological media may affect the corona composition. Here, we used nano-LC MS/MS to compare the protein corona contents obtained after using two different separation methods...
April 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28425913/loss-of-dnmt3a-and-dnmt3b-does-not-affect-epidermal-homeostasis-but-promotes-squamous-transformation-through-ppar-%C3%AE
#5
Lorenzo Rinaldi, Alexandra Avgustinova, Mercé Martin, Debayan Datta, Guiomar Solanas, Neus Prats, Salvador Aznar Benitah
The DNA methyltransferase Dnmt3a suppresses tumorigenesis in models of leukemia and lung cancer. Conversely, deregulation of Dnmt3b is thought to generally promote tumorigenesis. However, the role of Dnmt3a and Dnmt3b in many types of cancer remains undefined. Here we show that Dnmt3a and Dnmt3b are dispensable for homeostasis of the murine epidermis. However, loss of Dnmt3a-but not Dnmt3b-increases the number of carcinogen-induced squamous tumors, without affecting tumor progression. Only upon combined deletion of Dnmt3a and Dnmt3b, squamous carcinomas become more aggressive and metastatic...
April 20, 2017: ELife
https://www.readbyqxmd.com/read/28423537/limitations-in-predicting-pam50-intrinsic-subtype-and-risk-of-relapse-score-with-ki67-in-estrogen-receptor-positive-her2-negative-breast-cancer
#6
Aranzazu Fernandez-Martinez, Tomás Pascual, Giuseppe Perrone, Serafin Morales, Juan de la Haba, Milagros González-Rivera, Patricia Galván, Francesca Zalfa, Michela Amato, Lucia Gonzalez, Miquel Prats, Federico Rojo, Luis Manso, Laia Paré, Immaculada Alonso, Joan Albanell, Ana Vivancos, Antonio González, Judit Matito, Sonia González, Pedro Fernandez, Barbara Adamo, Montserrat Muñoz, Margarita Viladot, Carme Font, Francisco Aya, Maria Vidal, Rosalía Caballero, Eva Carrasco, Vittorio Altomare, Giuseppe Tonini, Aleix Prat, Miguel Martin
PAM50/Prosigna gene expression-based assay identifies three categorical risk of relapse groups (ROR-low, ROR-intermediate and ROR-high) in post-menopausal patients with estrogen receptor estrogen receptor-positive (ER+)/ HER2-negative (HER2-) early breast cancer. Low risk patients might not need adjuvant chemotherapy since their risk of distant relapse at 10-years is below 10% with endocrine therapy only. In this study, 517 consecutive patients with ER+/HER2- and node-negative disease were evaluated for Ki67 and Prosigna...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28410390/accessory-gene-regulator-agr-functionality-in-staphylococcus-aureus-derived-from-lower-respiratory-tract-infections
#7
Meissiner Gomes-Fernandes, Maisem Laabei, Natalia Pagan, Jessica Hidalgo, Sònia Molinos, Raquel Villar Hernandez, Dídac Domínguez-Villanueva, A Toby A Jenkins, Alicia Lacoma, Cristina Prat
OBJECTIVE: Characterization of Staphylococcus aureus clinical isolates derived from lower respiratory tract infections (LRTIs), and correlation between the functionality of the accessory gene regulator (Agr) and genotypic and phenotypic characteristics, clinical variables and clinical outcome. METHODS: S aureus isolates derived from LRTIs and control groups (nasal carriage and bacteraemia) were genotyped using StaphyType DNA microarray. Agr activity was evaluated using the CAMP synergistic haemolysis assay and the Vesicle Lysis Test (VLT)...
2017: PloS One
https://www.readbyqxmd.com/read/28405946/new-generation-of-three-dimensional-tools-to-learn-anatomy
#8
Roberto D Tabernero Rico, Juan A Juanes Méndez, Alberto Prats Galino
We present a new generation tool based of interactive 3D models. This models are based on the radiological two-dimensional images by computed tomography imaging. Our article focuses on the anatomical region of the skull base. These new three-dimensional models offer a wide field of application in the learning, as they offer multiple visualization tools (rotation, scrolling, zoom…). In this way, understanding of the anatomical region is facilitated. A feature to be dismissed is that a professional workstation is not required to work with three-dimensional models, since a personal computer can be viewed and interacted with the models...
May 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28405321/the-expansion-of-endoscopic-submucosal-dissection-in-france-a-prospective-nationwide-survey
#9
Maximilien Barret, Vincent Lepilliez, Dimitri Coumaros, Stanislas Chaussade, Sarah Leblanc, Thierry Ponchon, Fabien Fumex, Edouard Chabrun, Paul Bauret, Christophe Cellier, Emmanuel Coron, Philippe Bichard, Philippe Bulois, Antoine Charachon, Gabriel Rahmi, Serge Bellon, Marc Lerhun, Jean-Pierre Arpurt, Stéphane Koch, Bertrand Napoleon, Eric Vaillant, Anouk Esch, Said Farhat, Francoise Robin, Nadira Kaddour, Frédéric Prat
INTRODUCTION: Early reports of endoscopic submucosal dissection (ESD) in Europe suggested high complication rates and disappointing outcomes compared to publications from Japan. Since 2008, we have been conducting a nationwide survey to monitor the outcomes and complications of ESD over time. MATERIAL AND METHODS: All consecutive ESD cases from 14 centers in France were prospectively included in the database. Demographic, procedural, outcome and follow-up data were recorded...
February 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28398265/a-waist-worn-inertial-measurement-unit-for-long-term-monitoring-of-parkinson-s-disease-patients
#10
Daniel Rodríguez-Martín, Carlos Pérez-López, Albert Samà, Andreu Català, Joan Manuel Moreno Arostegui, Joan Cabestany, Berta Mestre, Sheila Alcaine, Anna Prats, María de la Cruz Crespo, Àngels Bayés
Inertial measurement units (IMUs) are devices used, among other fields, in health applications, since they are light, small and effective. More concretely, IMUs have been demonstrated to be useful in the monitoring of motor symptoms of Parkinson's disease (PD). In this sense, most of previous works have attempted to assess PD symptoms in controlled environments or short tests. This paper presents the design of an IMU, called 9 × 3, that aims to assess PD symptoms, enabling the possibility to perform a map of patients' symptoms at their homes during long periods...
April 11, 2017: Sensors
https://www.readbyqxmd.com/read/28390882/risk-benefit-on-quality-of-life-after-total-knee-arthroplasty-in-octogenarians
#11
Alejandro Lizaur-Utrilla, Daniel Martinez-Mendez, Francisco A Miralles-Muñoz, Luis Marco-Gomez, Fernando A Lopez-Prats
BACKGROUND: Clinical outcomes of total knee arthroplasty (TKA) in very older patients have been widely studied, but the available evidence on quality of life (QOL) is limited. The objective was to evaluate the impact of TKA on the QOL in octogenarian patients and assess whether the risk-benefit justified surgery. METHODS: Prospective study comparing 143 octogenarian and 149 septuagenarian patients. QOL was assessed with the Short Form-12 (SF-12) and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) questionnaires and functional outcomes with the Knee Society score (KSS)...
March 16, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28383897/topological-transformation-of-a-metal-organic-framework-triggered-by-ligand-exchange
#12
Greco González Miera, Antonio Bermejo Gómez, Peter J Chupas, Belén Martín-Matute, Karena W Chapman, Ana E Platero-Prats
Here we describe the topological transformation of the pores of a new framework in the bio-MOF-100 family (dia-c) into the known isomer (lcs) by doubling the pore volume, which occurs during postsynthesis modifications. During this transformation, reassembling of the metal-organic framework (MOF) building blocks into a completely different framework occurs, involving breaking/forming of metal-ligand bonds. MOF crystallinity and local structure are retained, as determined by powder X-ray diffraction (PXRD) and pair distribution function (PDF) analyses, respectively...
April 6, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28382837/long-term-disability-trajectories-in-primary-progressive-ms-patients-a-latent-class-growth-analysis
#13
Alessio Signori, Guillermo Izquierdo, Alessandra Lugaresi, Raymond Hupperts, Francois Grand'Maison, Patrizia Sola, Dana Horakova, Eva Havrdova, Alexandre Prat, Marc Girard, Pierre Duquette, Cavit Boz, Pierre Grammond, Murat Terzi, Bhim Singhal, Raed Alroughani, Thor Petersen, Cristina Ramo, Celia Oreja-Guevara, Daniele Spitaleri, Vahid Shaygannejad, Helmut Butzkueven, Tomas Kalincik, Vilija Jokubaitis, Mark Slee, Ricardo Fernandez Bolaños, Jose Luis Sanchez-Menoyo, Eugenio Pucci, Franco Granella, Jeannette Lechner-Scott, Gerardo Iuliano, Stella Hughes, Roberto Bergamaschi, Bruce Taylor, Freek Verheul, Maria Edite Rio, Maria Pia Amato, Seyed Aidin Sajedi, Nastaran Majdinasab, Vincent Van Pesch, Maria Pia Sormani, Maria Trojano
BACKGROUND: Several natural history studies on primary progressive multiple sclerosis (PPMS) patients detected a consistent heterogeneity in the rate of disability accumulation. OBJECTIVES: To identify subgroups of PPMS patients with similar longitudinal trajectories of Expanded Disability Status Scale (EDSS) over time. METHODS: All PPMS patients collected within the MSBase registry, who had their first EDSS assessment within 5 years from onset, were included in the analysis...
April 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28382371/characteristics-of-dyspnoea-and-associated-clinical-outcomes-in-the-champion-phoenix-study
#14
William A Parker, Deepak L Bhatt, Jayne Prats, Jonathan R S Day, Philippe Gabriel Steg, Gregg W Stone, Christian W Hamm, Kenneth W Mahaffey, Matthew J Price, C Michael Gibson, Harvey D White, Robert F Storey
Dyspnoea may be induced by some reversibly-binding P2Y12 inhibitors, including cangrelor and ticagrelor. Dyspnoea was not associated with any compromise to the efficacy of ticagrelor in the PLATO study. The CHAMPION PHOENIX study (NCT01156571) compared initial treatment with cangrelor versus initial treatment with clopidogrel in patients undergoing PCI. We investigated the incidence, characteristics, and associated clinical outcomes in patients with dyspnoea in CHAMPION PHOENIX. Adverse events (AEs) of dyspnoea to 48 hours were recorded in patients randomised to cangrelor or clopidogrel in CHAMPION PHOENIX...
April 6, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28379456/patterns-of-polymorphism-at-the-self-incompatibility-locus-in-1-083-arabidopsis-thaliana-genomes
#15
Takashi Tsuchimatsu, Pauline M Goubet, Sophie Gallina, Anne-Catherine Holl, Isabelle Fobis-Loisy, Hélène Bergès, William Marande, Elisa Prat, Dazhe Meng, Quan Long, Alexander Platzer, Magnus Nordborg, Xavier Vekemans, Vincent Castric
Although the transition to selfing in the model plant Arabidopsis thaliana involved the loss of the self-incompatibility (SI) system, it clearly did not occur due to the fixation of a single inactivating mutation at the locus determining the specificities of SI (the S-locus). At least three groups of divergent haplotypes (haplogroups), corresponding to ancient functional S-alleles, have been maintained at this locus, and extensive functional studies have shown that all three carry distinct inactivating mutations...
April 4, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28375444/self-assembling-peptide-matrix-for-the-prevention-of-esophageal-stricture-after-endoscopic-resection-a-randomized-controlled-trial-in-a-porcine-model
#16
M Barret, B Bordaçahar, F Beuvon, B Terris, M Camus, R Coriat, S Chaussade, F Batteux, F Prat
Esophageal stricture formation after extensive endoscopic resection remains a major limitation of endoscopic therapy for early esophageal neoplasia. This study assessed a recently developed self-assembling peptide (SAP) matrix as a wound dressing after endoscopic resection for the prevention of esophageal stricture. Ten pigs were randomly assigned to the SAP or the control group after undergoing a 5-cm-long circumferential endoscopic submucosal dissection of the lower esophagus. Esophageal diameter on endoscopy and esophagogram, weight variation, and histological measurements of fibrosis, granulation tissue, and neoepithelium were assessed in each animal...
May 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28368446/dysregulation-of-placental-mirna-in-maternal-obesity-is-associated-with-pre-and-post-natal-growth
#17
Gemma Carreras-Badosa, Alexandra Bonmatí, Francisco-Jose Ortega, Josep-Maria Mercader, Marta Guindo-Martínez, David Torrents, Anna Prats-Puig, Jose-Maria Martinez-Calcerrada, Francis DE Zegher, Lourdes Ibáñez, Jose-Manuel Fernandez-Real, Abel Lopez-Bermejo, Judit Bassols
Context: Human placenta exhibits a specific miRNA expression pattern. Some of these miRNAs are dysregulated in pregnancy disorders like preeclampsia and intrauterine growth restriction, and are potential biomarkers for these pathologies. Objective: To study the placental miRNA profile in pregnant women with pregestational (preOB) or gestational obesity (gestOB) and explore the associations of placental miRNAs dysregulated in maternal obesity with pre- and post-natal growth...
March 20, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28366379/femtosecond-laser-assisted-capsulotomy-for-treatment-of-bilateral-anterior-capsule-contraction
#18
Marta Ibarz, Jose Luis Rodríguez-Prats, Pedro Tañá
A 51-year-old woman developed severe fibrosis and occlusion of the visual axis in 1 eye, maintaining a pinhole aperture in the fellow eye, 2 months after uneventful cataract surgery and implantation of a hydrophilic trifocal intraocular lens in the capsular bag. She had not exhibited any risk factor for anterior capsule contraction preoperatively. Femtosecond laser-assisted capsulotomy with a fluid-filled interface system was used to perform a simultaneous anterior capsulotomy in both eyes. Preoperative calculations of the incision depth of the capsulotomy were performed using optical coherence tomography (OCT) and adjusted intraoperatively with the OCT system of the femtosecond laser...
February 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28365069/quality-of-life-and-prognostic-factors-after-intra-articular-tibial-pilon-fracture
#19
Jorge De-Las-Heras-Romero, Ana M Lledo-Alvarez, Alejandro Lizaur-Utrilla, Fernando A Lopez-Prats
BACKGROUND: Intra-articular tibial plafond fractures are a challenge for the surgeon with generally poor functional outcomes. The purpose was to assess the impact of this injury on patient quality of life (QOL), as well as analyzed the predictor factors. METHODS: Retrospective study of 47 patients with mean age of 44.4 (range 18-79) years. Patients were also invited for new clinical and radiological assessments. QOL was evaluated by the Short Form-36 questionnaire and compared to the standard in the age-matched general population...
March 22, 2017: Injury
https://www.readbyqxmd.com/read/28363106/individual-differences-in-the-simon-effect-are-underpinned-by-differences-in-the-competitive-dynamics-in-the-basal-ganglia-an-experimental-verification-and-a-computational-model
#20
Andrea Stocco, Nicole L Murray, Brianna L Yamasaki, Taylor J Renno, Jimmy Nguyen, Chantel S Prat
Cognitive control is thought to be made possible by the activity of the prefrontal cortex, which selectively uses task-specific representations to bias the selection of task-appropriate responses over more automated, but inappropriate, ones. Recent models have suggested, however, that prefrontal representations are in turn controlled by the basal ganglia. In particular, neurophysiological considerations suggest that the basal ganglia's indirect pathway plays a pivotal role in preventing irrelevant information from being incorporated into a task, thus reducing response interference due to the processing of inappropriate stimuli dimensions...
March 28, 2017: Cognition
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