keyword
MENU ▼
Read by QxMD icon Read
search

IBD-associated colorectal cancer

keyword
https://www.readbyqxmd.com/read/28333358/cancer-risk-in-the-early-stages-of-inflammatory-bowel-disease-in-korean-patients-a-nationwide-population-based-study
#1
Yoon Suk Jung, Minkyung Han, Won Ho Kim, Sohee Park, Jae Hee Cheon
Background and Aims: The association between inflammatory bowel disease (IBD) and cancer remains poorly defined in Asian populations. Therefore, we conducted a nationwide population-based study to determine the cancer risk in Korean patients with IBD. Methods: Using the National Health Insurance claims data, we collected data on patients diagnosed with IBD (5,595 Crohn's disease [CD] and 10,049 ulcerative colitis [UC]) from 2011 to 2014. Standardized incidence ratios (SIRs) of overall and site-specific cancers in IBD patients in comparison with the general population were calculated...
March 16, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28301579/a-novel-model-of-colitis-associated-cancer-in-samp1-yitfc-mice-with-crohn-s-disease-like-ileitis
#2
Paola Menghini, Luca Di Martino, Loris R Lopetuso, Daniele Corridoni, Joshua C Webster, Wei Xin, Kristen O Arseneau, Minh Lam, Theresa T Pizarro, Fabio Cominelli
Patients with inflammatory bowel disease (IBD) are at increased risk for developing colorectal cancer. Evidence suggests that colonic dysplasia and colitis-associated cancer (CAC) are often linked to repeated cycles of epithelial cell injury and repair in the context of chronic production of inflammatory cytokines. Several mouse models of CAC have been proposed, including chemical induction through exposure to dextran sulfate sodium (DSS) with the genotoxic agents azoxymethane (AOM), 1,2-dymethylhydrazine (DHM) or targeted genetic mutations...
2017: PloS One
https://www.readbyqxmd.com/read/28278072/chronic-inflammation-confers-to-the-metabolic-reprogramming-associated-with-tumorigenesis-of-colorectal-cancer
#3
Dingding Qu, Liangliang Shen, Shaoqing Liu, Huichen Li, Yongzheng Ma, Ruohan Zhang, Kaichun Wu, Libo Yao, Jipeng Li, Jian Zhang
It's well known that microenvironment inflammatory signals could promote cancer development and progression. In colorectal cancer (CRC), chronic inflammation is a major driving mechanism for the development of CRC in patients having long-standing inflammatory bowel disease (IBD). Though it has been addressed that cancer cells ferment much of their glucose supply into lactate regardless of the presence of oxygen, it is unclear whether cell metabolism has been reprogramed during the process from IBD to CRC. Herein, with dextran sulfate sodium (DSS)-induced mouse colitis model, we found that inflammation upregulated key glycolytic enzymes expression via activation of STAT3/c-Myc signaling pathway...
February 25, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28261835/systematic-review-with-meta-analysis-use-of-5-aminosalicylates-and-risk-of-colorectal-neoplasia-in-patients-with-inflammatory-bowel-disease
#4
REVIEW
S Bonovas, G Fiorino, T Lytras, G Nikolopoulos, L Peyrin-Biroulet, S Danese
BACKGROUND: The relationship of 5-aminosalicylates' use with the risk of colorectal neoplasia in patients with inflammatory bowel disease (IBD) has been the focus of a growing body of research. AIM: To investigate this association through an updated meta-analysis of observational studies. METHODS: PubMed, Scopus and major conference proceedings were searched up to December 2016. The identified studies were evaluated for publication bias and heterogeneity...
March 6, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28243990/associations-between-single-nucleotide-polymorphisms-and-inflammatory-bowel-disease-associated-colorectal-cancers-in-inflammatory-bowel-disease-patients-a-meta-analysis
#5
REVIEW
H Li, Z Jin, X Li, L Wu, J Jin
PURPOSE: To assess the correlation between single-nucleotide polymorphisms (SNPs) and inflammatory bowel disease (IBD)-associated colorectal cancer (CRC) in IBD patients. METHODS: A systematic search of PubMed, EmBase, and Cochrane databases was performed. Five genetic models (allelic, dominant, recessive, heterozygous and homozygous models) were used to analyze the associations, and trial sequential analysis was used to analyze the robustness of the results. RESULTS: We collected and analyzed the results of seven trials including a total of 2287 patients in our meta-analysis...
February 27, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28219317/dietary-fiber-gap-and-host-gut-microbiota
#6
Meng Han, Ping Liu, Defa Li, Yuan Li, Xi Ma
Accumulating evidence are dramatically increasing access to the facts that the gut microbiota plays a pivotal role in host metabolism and health, which revealed the possibility of a plethora of associations between gut bacteria and human diseases. Several functional roles carried out by a major class of host's diet, such as fiber. Fiber is the main source of microbiota-accessible carbohydrate in the diet of humans. In modern diet, it is difficult to intake dietary fiber as enough as recommended standard. The low-fiber diet in the modern life, known as fiber gap, can trigger to a substantial depletion of the human gut microbiota diversity and beneficial metabolites...
February 20, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28193514/microrna-301a-promotes-intestinal-inflammation-and-colitis-associated-cancer-development-by-inhibiting-btg1
#7
Chong He, Tianming Yu, Yan Shi, Caiyun Ma, Wenjing Yang, Leilei Fang, Mingming Sun, Wei Wu, Fei Xiao, Feifan Guo, Minhu Chen, Hong Yang, Jiaming Qian, Yingzi Cong, Zhanju Liu
BACKGROUND & AIMS: Intestinal tissues from patients with inflammatory bowel disease (IBD) and colorectal cancer have increased expression of microRNA-301a (MIR301A), compared to tissues from patients without IBD. We studied the mechanisms of MIR301A in progression of IBD in human tissues and mice. METHODS: We isolated intestinal epithelial cells (IECs) from colon biopsy samples of 153 patients with different stages of IBD activity, 6 patients with colitis-associated cancer (CAC), and 35 healthy individuals (controls), enrolled in the study in Shanghai, China...
February 10, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28160571/the-oncoprotein-gankyrin-promotes-the-development-of-colitis-associated-cancer-through-activation-of-stat3
#8
Toshiharu Sakurai, Hiroaki Higashitsuji, Hiroshi Kashida, Tomohiro Watanabe, Yoriaki Komeda, Tomoyuki Nagai, Satoru Hagiwara, Masayuki Kitano, Naoshi Nishida, Takaya Abe, Hiroshi Kiyonari, Katsuhiko Itoh, Jun Fujita, Masatoshi Kudo
Although long-standing colonic inflammation due to refractory inflammatory bowel disease (IBD) promotes the development of colitis-associated cancer (CAC), the molecular mechanisms accounting for the development of CAC remains largely unknown. In this study, we investigated the role of gankyrin in the development of CAC since gankyrin is overexpressed in sporadic colorectal cancers. We analyzed gene expression of colon tissues obtained from 344 patients with IBD and CAC and found that expression of gankyrin was much higher in colonic mucosa of patients with refractory IBD than in those with IBD in remission...
February 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28155620/nlrp3-inhibitors-as-potential-therapeutic-agents-for-treatment-of-inflammatory-bowel-disease
#9
Agampodi Promoda Perera, Dale Kunde, Rajaraman Eri
BACKGROUND: Inflammatory bowel disease (IBD) is a group of intestinal disorders characterised by chronic relapsing inflammation of the small intestine and colon. IBD manifests as either ulcerative colitis or Crohn's disease and increases the risk of developing colorectal cancer. METHODS: Here, we have reviewed current treatment regimen for IBD utilising anti-inflammatory drugs, immune system suppressors and antibiotics or a combination of these. However, these therapeutics lead to a number of adverse effects, remission or significant non-responsiveness creating an urgent need to develop potent drugs with novel mechanisms of action for IBD...
February 1, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28089111/the-molecular-landscape-of-colitis-associated-carcinogenesis
#10
Deborah Saraggi, Matteo Fassan, Claudia Mescoli, Marco Scarpa, Nicola Valeri, Andrea Michielan, Renata D'Incá, Massimo Rugge
In spite of the well-established histopathological phenotyping of IBD-associated preneoplastic and neoplastic lesions, their molecular landscape remains to be fully elucidated. Several studies have pinpointed the initiating role of longstanding/relapsing inflammatory insult on the intestinal mucosa, with the activation of different pro-inflammatory cytokines (TNF-α, IL-6, IL-10, IFN-γ), chemokines and metabolites of arachidonic acid resulting in the activation of key transcription factors such as NF-κB. Longstanding inflammation may also modify the intestinal microbiota, prompting the overgrowth of genotoxic microorganisms, which may act as further cancer promoters...
December 21, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28078433/a-meta-analysis-of-the-clinicopathological-characteristics-and-survival-outcomes-of-inflammatory-bowel-disease-associated-colorectal-cancer
#11
REVIEW
Ian S Reynolds, Aobhlinn O'Toole, Joseph Deasy, Deborah A McNamara, John P Burke
PURPOSE: The current study aims to use meta-analytical techniques to compare the clinicopathological characteristics and survival outcomes of inflammatory bowel disease (IBD) associated and sporadic colorectal carcinoma (CRC). Patients with IBD have an established increased risk of developing CRC. There is no consensus, however, on the clinicopathological characteristics and survival outcomes of IBD associated CRC when compared to sporadic CRC. METHODS: A comprehensive search for published studies comparing IBD associated and sporadic CRC was performed...
January 11, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28077799/kras-and-tp53-mutations-in-inflammatory-bowel-disease-associated-colorectal-cancer-a-meta-analysis
#12
Lijun Du, John J Kim, Jinhua Shen, Binrui Chen, Ning Dai
Although KRAS and TP53 mutations are common in both inflammatory bowel disease-associated colorectal cancer (IBD-CRC) and sporadic colorectal cancer (S-CRC), molecular events leading to carcinogenesis may be different. Previous studies comparing the frequency of KRAS and TP53 mutations in IBD-CRC and S-CRC were inconsistent. We performed a meta-analysis to compare the presence of KRAS and TP53 mutations among patients with IBD-CRC, S-CRC, and IBD without dysplasia. A total of 19 publications (482 patients with IBD-CRC, 4,222 with S-CRC, 281 with IBD without dysplasia) met the study inclusion criteria...
January 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28050782/colorectal-cancer-in-inflammatory-bowel-diseases-a-population-based-study-in-utah
#13
N Jewel Samadder, John F Valentine, Stephen Guthery, Harminder Singh, Charles N Bernstein, Yuan Wan, Jathine Wong, Kenneth Boucher, Lisa Pappas, Kerry Rowe, Mary Bronner, Cornelia M Ulrich, Randall W Burt, Karen Curtin, Ken R Smith
BACKGROUND AND AIMS: The molecular, endoscopic, and histological features of IBD-associated CRC differ from sporadic CRC. The objective of this study was to describe the prevalence, clinical features, and prognosis of IBD-associated CRC compared to patients with sporadic CRC in a US statewide population-based cohort. METHODS: All newly diagnosed cases of CRC between 1996 and 2011 were obtained from Utah Cancer Registry. IBD was identified using a previously validated algorithm, from statewide databases of Intermountain Healthcare, University of Utah Health Sciences, and the Utah Population Database...
January 3, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28045548/vitamin-d-reduces-colitis-and-inflammation-associated-colorectal-cancer-in-mice-independent-of-nod2
#14
Ihsan Elimrani, Jamie Koenekoop, Serge Dionne, Valerie Marcil, Edgar Delvin, Emile Levy, Ernest G Seidman
Inflammatory bowel disease (IBD) patients are at increased risk of developing colorectal cancer (CRC). Vitamin D (vD) induces NOD2 gene expression, enhancing immunity, while deficiency impairs intestinal epithelial integrity, increasing inflammation. This study investigated the effect of vD on CRC in colitis, and if preventive benefits are mediated via NOD2. Inflammation-associated CRC was induced by treating C57BL/6J and Nod2(-/-) mice with azoxymethane (AOM) and dextran sodium sulfate (DSS) cycles (×3). vD-deficient mice displayed more severe colitis compared to vD-supplemented mice, with greater weight loss, higher colitis activity index, increased colonic weight/length ratios, and lower survival rates...
January 3, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28028368/nodular-lymphoid-hyperplasia-a-marker-of-low-grade-inflammation-in-irritable-bowel-syndrome
#15
Anna Chiara Piscaglia, Lucrezia Laterza, Valentina Cesario, Viviana Gerardi, Rosario Landi, Loris Riccardo Lopetuso, Giovanni Calò, Giovanna Fabbretti, Massimo Brisigotti, Maria Loredana Stefanelli, Antonio Gasbarrini
AIM: To evaluate the prevalence of nodular lymphoid hyperplasia (NLH) in adult patients undergoing colonoscopy and its association with known diseases. METHODS: We selected all cases showing NLH at colonoscopy in a three-year timeframe, and stratified them into symptomatic patients with irritable bowel syndrome (IBS)-type symptoms or suspected inflammatory bowel disease (IBD), and asymptomatic individuals undergoing endoscopy for colorectal cancer screening. Data collection included medical history and final diagnosis...
December 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27995656/the-effects-of-aminosalicylates-or-thiopurines-on-the-risk-of-colorectal-cancer-in-inflammatory-bowel-disease
#16
F Carrat, P Seksik, J-F Colombel, L Peyrin-Biroulet, L Beaugerie
BACKGROUND: Whether aminosalicylates or thiopurines reduce the risk of colorectal cancer (CRC) in inflammatory bowel (IBD) disease is controversial. AIM: To assess simultaneously the chemopreventive effect of aminosalicylates or thiopurines in a case-control study nested in the CESAME observational cohort that enrolled consecutive patients with IBD between May 2004 and June 2005. Patients were followed up to December 2007. METHODS: Study population comprised 144 case patients who developed CRC from the diagnosis of IBD (65 and 79 cases diagnosed, respectively, before and from 2004, starting year of the prospective observational period of CESAME) and 286 controls matched for gender, age, IBD subtype and year of diagnosis, and cumulative extent of colitis...
December 19, 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27939424/enhanced-mucosal-defense-and-reduced-tumor-burden-in-mice-with-the-compromised-negative-regulator-irak-m
#17
Daniel E Rothschild, Yao Zhang, Na Diao, Christina K Lee, Keqiang Chen, Clayton C Caswell, Daniel J Slade, Richard F Helm, Tanya LeRoith, Liwu Li, Irving C Allen
Aberrant inflammation is a hallmark of inflammatory bowel disease (IBD) and colorectal cancer. IRAK-M is a critical negative regulator of TLR signaling and overzealous inflammation. Here we utilize data from human studies and Irak-m(-/-) mice to elucidate the role of IRAK-M in the modulation of gastrointestinal immune system homeostasis. In human patients, IRAK-M expression is up-regulated during IBD and colorectal cancer. Further functional studies in mice revealed that Irak-m(-/-) animals are protected against colitis and colitis associated tumorigenesis...
February 2017: EBioMedicine
https://www.readbyqxmd.com/read/27938789/surveillance-of-patients-with-inflammatory-bowel-disease
#18
REVIEW
Jessica X Yu, James E East, Tonya Kaltenbach
Patients with inflammatory bowel disease involving the colon are at increased risk for developing colorectal cancer. Colonoscopy surveillance is important to identify and treat IBD associated dysplasia. The SCENIC consensus provides evidence-based recommendations for optimal surveillance and management of dysplasia in IBD. Chromoendoscopy, with the surface application of dyes to enhance mucosal visualization, is the superior endoscopic surveillance strategy to detect dysplasia. Most dysplasia is visible, and can be endoscopically resected...
December 2016: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/27926694/involvement-of-activated-cdc42-kinase1-in-colitis-and-colorectal-neoplasms
#19
Chaolan Lv, Xinmei Zhao, Hongxiang Gu, Liyun Huang, Sanxi Zhou, Fachao Zhi
BACKGROUND Activated Cdc42 kinase1 (ACK1) is a non-receptor tyrosine kinase which is critical for cell survival, proliferation, and migration. Genomic amplification of ACK1 has been reported in multiple human cancers. We aimed to investigate ACK1 protein expression in colorectal mucosa with inflammation and neoplasm, and to evaluate its correlation with disease activity and severity. MATERIAL AND METHODS A total of 250 individuals who underwent total colonoscopy were collected randomly from January 2007 to May 2013 in Nanfang Hospital, Guangzhou, China...
December 7, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27915991/control-of-inflammatory-bowel-disease-and-colorectal-cancer-by-synthetic-vitamin-d-receptor-ligands
#20
Ichiro Takada, Makoto Makishima
Vitamin D deficiency and insufficiency are associated with an increased risk of cancer, autoimmune disease, inflammation, infection, cardiovascular disease and metabolic disease, as well as bone and mineral disorders. The vitamin D receptor (VDR), a member of the nuclear receptor superfamily, is a receptor for the active form of vitamin D, 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3], and mediates vitamin D regulation of specific target gene expression. The secondary bile acid lithocholic acid, which is produced by intestinal bacteria, is another natural VDR ligand...
December 2, 2016: Current Medicinal Chemistry
keyword
keyword
12051
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"