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Inhibin b in girls

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https://www.readbyqxmd.com/read/28593614/circulating-anti-m%C3%A3-llerian-hormone-amh-associates-with-the-maturity-of-boys-drawings-does-amh-slow-cognitive-development-in-males
#1
Kirstie Morgan, Ted Ruffman, David K Bilkey, Ian S McLennan
PURPOSE: High levels of circulating anti-Müllerian hormone are unique to developing males, but the function of anti-Müllerian hormone in boys is unknown. In mice, anti-Müllerian hormone contributes to the male biases in the brain, but its receptors are present throughout non-sexually dimorphic portions of the brain. In humans, the speed of maturation is the most overt difference between girls and boys. We postulate that this is because anti-Müllerian hormone slows the maturation of the male human brain...
June 7, 2017: Endocrine
https://www.readbyqxmd.com/read/28438374/validity-of-self-assessed-sexual-maturation-against-physician-assessments-and-hormone-levels
#2
Jorge E Chavarro, Deborah J Watkins, Myriam C Afeiche, Zhenzhen Zhang, Brisa N Sánchez, David Cantonwine, Adriana Mercado-García, Clara Blank-Goldenberg, John D Meeker, Martha María Téllez-Rojo, Karen E Peterson
OBJECTIVE: To compare self-report and physician assessments of sexual maturation against serum hormone markers to evaluate the hypothesis that the validity of self-assessed sexual maturation is underestimated in traditional validation studies. STUDY DESIGN: We adapted a self-assessment instrument that 248 Mexican children and adolescents, aged 8-13 years, completed. The participants were examined by a trained pediatrician and provided fasting blood samples for measurement of reproductive hormones (eg, testosterone, estradiol, sex hormone-binding globulin, inhibin B) and other hormones (eg, C-peptide, insulin-like growth factor 1, leptin, dehydroepiandrosterone sulfate) known to change during adolescence...
April 21, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28161677/serum-anti-m%C3%A3-llerian-hormone-and-inhibin-b-as-potential-markers-for-progressive-central-precocious-puberty-in-girls
#3
Ting Chen, Haiying Wu, Rongrong Xie, Fengyun Wang, Xiuli Chen, Hui Sun, Linqi Chen
STUDY OBJECTIVE: To investigate the potential of serum anti-Müllerian hormone (AMH) and inhibin B (INHB) levels as markers for pubertal progression rate in girls with central precocious puberty (CPP). DESIGN, SETTING, PARTICIPANTS, INTERVENTIONS, AND MAIN OUTCOME MEASURES: A total of 148 girls were enrolled, including 65 girls with premature thelarche and 83 girls with CPP, grouped on the basis of the results of gonadotropin-releasing hormone stimulation tests. Girls with CPP underwent a 6-month follow-up, and were further divided into 2 subgroups: the progressive CPP (P-CPP) group (n = 55) and the slowly P-CPP (SP-CPP) group (n = 28)...
February 1, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/27927844/congenital-hypogonadotropic-hypogonadism-functional-hypogonadotropism-or-constitutional-delay-of-growth-and-puberty-an-analysis-of-a-large-patient-series-from-a-single-tertiary-center
#4
Tero Varimo, Päivi J Miettinen, Johanna Känsäkoski, Taneli Raivio, Matti Hero
STUDY QUESTION: What diagnoses underlie delayed puberty (DP) and predict its outcome? SUMMARY ANSWER: A multitude of different diagnoses underlie DP, and in boys a history of cryptorchidism, small testicular size and slow growth velocity (GV) predict its clinical course. WHAT IS KNOWN ALREADY: DP is caused by a variety of underlying etiologies. Hormonal markers can be used in the differential diagnosis of DP but none of them have shown complete diagnostic accuracy...
January 2017: Human Reproduction
https://www.readbyqxmd.com/read/27680030/gonadal-function-in-boys-with-newly-diagnosed-cancer-before-the-start-of-treatment
#5
Kiki M G J Wigny, Wendy van Dorp, Anne-Lotte L F van der Kooi, Yolanda B de Rijke, Andrica C H de Vries, Marij Smit, Saskia M F Pluijm, Erica L T van den Akker, Rob Pieters, Joop S E Laven, Marry M van den Heuvel-Eibrink
STUDY QUESTION: Are Inhibin B and testosterone levels reduced in boys with newly diagnosed cancer prior to therapy? SUMMARY ANSWER: Pretreatment serum levels of Inhibin B and testosterone are significantly reduced in boys with newly diagnosed cancer, compared to reference values. WHAT IS ALREADY KNOWN: Disease-related gonadal impairment has been demonstrated in girls and young women diagnosed with cancer, prior to therapy. STUDY DESIGN, SIZE, DURATION: We conducted a descriptive study in boys newly diagnosed with cancer between January 2006 and February 2014...
November 2016: Human Reproduction
https://www.readbyqxmd.com/read/27384405/glandular-breast-tissue-volume-by-magnetic-resonance-imaging-in-100-healthy-peripubertal-girls-evaluation-of-clinical-tanner-staging
#6
Louise Fugl, Casper P Hagen, Mikkel G Mieritz, Jeanette Tinggaard, Eva Fallentin, Katharina M Main, Anders Juul
BACKGROUND: Appearance of glandular breast tissue may be difficult to distinguish from fat tissue by palpation, especially in obese girls. To our knowledge, validation of the clinical assessment of pubertal breast stages by magnetic resonance imaging (MRI) has never been performed. Our objective was to report normative data of glandular breast tissue volume and validate the clinical evaluation of pubertal breast staging by MRI of breast tissue and to evaluate circulating reproductive hormone levels and estrogen-dependent transabdominal ultrasound (TAUS) parameters as markers of glandular breast tissue...
October 2016: Pediatric Research
https://www.readbyqxmd.com/read/27270476/genetic-variations-in-fsh-action-affect-sex-hormone-levels-and-breast-tissue-size-in-infant-girls-a-pilot-study
#7
Louise Scheutz Henriksen, Casper P Hagen, Maria Assens, Alexander S Busch, Niels E Skakkebæk, Kristian Almstrup, Katharina M Main
CONTEXT: Single nucleotide polymorphisms altering FSH action (FSHB -211G>T, FSHR -29G>A, and FSHR 2039A>G) are associated with peripubertal and adult levels of reproductive hormones and age at pubertal onset in girls. OBJECTIVE: To investigate whether genetic polymorphisms altering FSH action affect serum levels of female reproductive hormones and breast development as early as during minipuberty. DESIGN: Longitudinal study. SETTING: Population-based cohort study...
August 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27125339/anti-m%C3%A3-llerian-hormone-and-inhibin-a-but-not-inhibin-b-or-insulin-like-peptide-3-may-be-used-as-surrogates-in-the-diagnosis-of-polycystic-ovary-syndrome-in-adolescents-preliminary-results
#8
Aylin Yetim, Çağcıl Yetim, Firdevs Baş, Oğuz Bülent Erol, Gülnaz Çığ, Ahmet Uçar, Feyza Darendeliler
OBJECTIVE: Polycystic ovary syndrome (PCOS) is a common endocrine problem in adolescents with an increasing prevalence of 30%. Pursuing new biomarkers with high specificity and sensitivity in the diagnosis of PCOS in adolescents is currently an active area of research. We aimed to investigate the diagnostic value of anti-Müllerian hormone (AMH), insulin-like peptide-3 (INSL3), inhibin-A (INH-A), and inhibin-B (INH-B) in adolescents with PCOS and also to determine the association, if any, between these hormones and clinical/laboratory findings related with hyperandrogenism...
September 1, 2016: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/27025240/circulating-makorin-ring-finger-protein-3-levels-decline-in-boys-before-the-clinical-onset-of-puberty
#9
RANDOMIZED CONTROLLED TRIAL
Tero Varimo, Leo Dunkel, Kirsi Vaaralahti, Päivi J Miettinen, Matti Hero, Taneli Raivio
OBJECTIVE: Makorin ring finger protein 3 (MKRN3) gene restrains the hypothalamic-pituitary-gonadal axis. In girls, peripheral levels of MKRN3 decline prior to the onset of puberty. We described longitudinal changes in serum MKRN3 levels in boys before and during puberty and assessed the effect of inhibition of estrogen biosynthesis on MKRN3 levels. DESIGN: Longitudinal serum samples from a double-blind, randomized controlled study in 30 boys (age range: 9.1-14.2years) with idiopathic short stature who received placebo (Pl; n=14) or aromatase inhibitor letrozole (Lz; 2...
June 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/26905078/genetic-variations-altering-fsh-action-affect-circulating-hormone-levels-as-well-as-follicle-growth-in-healthy-peripubertal-girls
#10
Alexander S Busch, Casper P Hagen, Kristian Almstrup, Katharina M Main, Anders Juul
STUDY QUESTION: Do variants of the genes encoding follicle stimulating hormone (FSH) beta subunit (B) and FSH receptor (R) impact circulating reproductive hormone levels and ovarian follicle maturation in healthy peripubertal girls? SUMMARY ANSWER: FSHB and FSHR genetic variants exert, alone or their combination, distinct effects on reproductive hormone levels as well as ovarian follicle maturation in healthy peripubertal girls. WHAT IS KNOWN ALREADY: FSHB and FSHR genetic variants impact reproductive hormone levels as well as associated pathologies in women...
April 2016: Human Reproduction
https://www.readbyqxmd.com/read/26608409/assessment-of-ovarian-reserve-in-euthyroid-adolescents-with-hashimoto-thyroiditis
#11
Ozgur Pirgon, Cigdem Sivrice, Hakan Demirtas, Bumin Dundar
AIM: We aimed to investigate the ovarian function and reserve in euthyroid adolescents (TSH < 2.5 mIU/L) diagnosed with Hashimoto thyroiditis (HT). METHODS: This case-control study included 30 adolescent girls (mean age 15.1 ± 1.4 years) newly diagnosed as HT with presence of high thyroid antibodies with gland heterogeneity in ultrasound and age-matched 30 healthy female subjects. Anti-ovarian antibody (AOAb), LH/FSH ratio, estradiol, anti-mullerian hormone (AMH), inhibin-B, total testosterone, antral follicle count, ovarian volumes and uterine length were measured...
2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/26411956/management-of-ovarian-cancer-in-younger-women
#12
REVIEW
K Uma Devi, N Purushotham, N Jayashree
BACKGROUND: Ovarian Cancer is a broad spectrum of diseases comprising several subtypes. Three major categories in younger women are germ cell tumor, sex cord stromal tumor and epithelial ovarian neoplasia. OBJECTIVE: literature search was for an update on management of ovarian cancer in young women. CONTEXT: Germ cell tumor is suspected in young girls presenting with solid ovarian neoplasm as abdominal mass, discomfort, dyspnea or pain abdomen...
2015: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/26355950/hypogonadotropic-hypogonadism-in-infants-with-congenital-hypopituitarism-a-challenge-to-diagnose-at-an-early-stage
#13
Débora Braslavsky, Romina Paula Grinspon, María Gabriela Ballerini, Patricia Bedecarrás, Nazareth Loreti, Gabriela Bastida, María Gabriela Ropelato, Ana Keselman, Stella Campo, Rodolfo Alberto Rey, Ignacio Bergadá
BACKGROUND: Combined pituitary hormone deficiency (CPHD) presents a wide spectrum of pituitary gland disorders. The postnatal gonadotropic surge provides a useful period to explore the gonadotropic axis for assessing the presence of congenital hypogonadotropic hypogonadism (CHH). AIM: To explore the functioning of the hypothalamic-pituitary-gonadal axis in the postnatal gonadotropic surge for an early diagnosis of CHH in newborns or infants suspected of having CPHD...
2015: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/26095287/accuracy-of-endocrine-tests-for-detecting-hypogonadotropic-hypogonadism-in-girls
#14
Gerhard Binder, Roland Schweizer, Peter Haber, Gunnar Blumenstock, Regina Braun
OBJECTIVE: To assess the accuracy of inhibin B and the gonadotropin releasing hormone agonist test for the diagnosis of hypogonadotropic hypogonadism (HH). STUDY DESIGN: We performed a retrospective analysis of data collected 2009-2014 using a strict clinical protocol. All prepubertal nonunderweight girls, aged 13-17.5 years with Tanner breast stage B1/B2 and low estradiol levels, were tested and re-examined at 6-month intervals (n = 21). Constitutional delay of growth and puberty was defined by spontaneous menarche; HH was identified by association with specific causes of HH or no spontaneous progress of puberty during follow-up...
September 2015: Journal of Pediatrics
https://www.readbyqxmd.com/read/25978111/amh-as-predictor-of-premature-ovarian-insufficiency-a-longitudinal-study-of-120-turner-syndrome-patients
#15
Stine Aa Lunding, Lise Aksglaede, Richard A Anderson, Katharina M Main, Anders Juul, Casper P Hagen, Anette T Pedersen
CONTEXT: The majority of Turner syndrome (TS) patients suffer from accelerated loss of primordial follicles. Low circulating levels of anti-Müllerian hormone (AMH) may predict the lack of spontaneous puberty in prepubertal girls and imminent premature ovarian insufficiency (POI) in TS women with preserved ovarian function. OBJECTIVES: To evaluate the association between circulating AMH and ovarian status in TS patients. DESIGN: Longitudinal observational cohort study...
July 2015: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/25746668/effects-of-prenatal-leydig-cell-function-on-the-ratio-of-the-second-to-fourth-digit-lengths-in-school-aged-children
#16
RANDOMIZED CONTROLLED TRIAL
Takahiko Mitsui, Atsuko Araki, Ayako Imai, Sakiko Sato, Chihiro Miyashita, Sachiko Ito, Seiko Sasaki, Takeya Kitta, Kimihiko Moriya, Kazutoshi Cho, Keita Morioka, Reiko Kishi, Katsuya Nonomura
Prenatal sex hormones can induce abnormalities in the reproductive system and adversely impact on genital development. We investigated whether sex hormones in cord blood influenced the ratio of the second to fourth digit lengths (2D/4D) in school-aged children. Of the 514 children who participated in a prospective cohort study on birth in Sapporo between 2002 and 2005, the following sex hormone levels were measured in 294 stored cord blood samples (135 boys and 159 girls); testosterone (T), estradiol (E), progesterone, LH, FSH, inhibin B, and insulin-like factor 3 (INSL3)...
2015: PloS One
https://www.readbyqxmd.com/read/25633306/in-utero-exposure-to-cigarette-smoking-environmental-tobacco-smoke-and-reproductive-hormones-in-us-girls-approaching-puberty
#17
Audra L Gollenberg, O Yaw Addo, Zhiwei Zhang, Mary L Hediger, John H Himes, Peter A Lee
BACKGROUND/AIMS: Evidence is unclear whether prenatal smoking affects age at menarche and pubertal development, and its impact upon hormones has not been well studied. We aim to identify potential pathways through which prenatal smoking and environmental tobacco smoke (ETS) affect reproductive hormones in girls approaching puberty. METHODS: We examined the association between prenatal smoking, current ETS and luteinizing hormone (LH) and inhibin B (InB) in 6- to 11-year-old girls in the 3rd National Health and Nutrition Examination Survey, 1988-1994...
2015: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/25585547/ovarian-and-uterine-development-and-hormonal-feedback-mechanism-in-a-46-xx-patient-with-cyp19a1-deficiency-under-low-dose-estrogen-replacement
#18
Marie-Anne Burckhardt, Verena Obmann, Rainer Wolf, Marco Janner, Christa E Flück, Primus E Mullis
BACKGROUND: Aromatase deficiency may result in a complete block of estrogen synthesis because of the failure to convert androgens to estrogens. In females, this results in virilisation at birth, ovarian cysts in prepuberty and lack of pubertal development but virilisation, thereafter. OBJECTIVE AND METHODS: We studied the impact of oral 17β-estradiol treatment on ovarian and uterine development, and on LH/FSH and inhibin B during the long-term follow-up of a girl harboring compound heterozygote point mutations in the CYP19A1 gene...
May 2015: Gynecological Endocrinology
https://www.readbyqxmd.com/read/25516081/longitudinal-assessment-of-circulating-insulin-like-peptide-3-levels-in-healthy-peripubertal-girls
#19
Casper P Hagen, Mikkel G Mieritz, John E Nielsen, Ravinder Anand-Ivell, Richard Ivell, Anders Juul
OBJECTIVE: To elucidate the natural course of circulating insulin-like peptide 3 (INSL3) levels according to puberty as well as its relation to other reproductive hormones. DESIGN: Population-based cohort study. SETTING: Not applicable. PATIENT(S): Healthy peripubertal girls (n = 10) examined every 6 months; total number of examinations was 84; median (range) per girl: 9 (4-10), including staging of pubertal breast development and blood samples...
March 2015: Fertility and Sterility
https://www.readbyqxmd.com/read/25485726/circulating-amh-reflects-ovarian-morphology-by-magnetic-resonance-imaging-and-3d-ultrasound-in-121-healthy-girls
#20
Casper P Hagen, Annette Mouritsen, Mikkel G Mieritz, Jeanette Tinggaard, Christine Wohlfart-Veje, Eva Fallentin, Vibeke Brocks, Karin Sundberg, Lisa Neerup Jensen, Richard A Anderson, Anders Juul, Katharina M Main
CONTEXT: In adult women, Anti-Müllerian hormone (AMH) is produced by small growing follicles, and circulating levels of AMH reflect the number of antral follicles as well as primordial follicles. Whether AMH reflects follicle numbers in healthy girls remains to be elucidated. OBJECTIVE: This study aimed to evaluate whether serum levels of AMH reflects ovarian morphology in healthy girls. DESIGN AND SETTING: This was a population-based cohort study involving the general community...
March 2015: Journal of Clinical Endocrinology and Metabolism
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