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Inhibin B

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https://www.readbyqxmd.com/read/29668033/sexual-dimorphism-in-postnatal-gonadotropin-levels-in-infancy-reflects-diverse-maturation-of-the-ovarian-and-testicular-hormone-synthesis
#1
Tanja Kuiri-Hänninen, Leo Dunkel, Ulla Sankilampi
BACKGROUND: The postnatal gonadotropin surge is sexually dimorphic: FSH levels predominate in girls and LH levels in boys. However, in preterm (PT) girls, both gonadotropin levels are higher than in PT boys. OBJECTIVE: To evaluate how gonadal maturation contributes to the sex differences in FSH and LH. DESIGN: Monthly follow-up of 58 full-term (FT, 29 boys) and 67 PT (33 boys) infants from one week (D7) to six months of age (M1-M6). Analyses were also done according to postmenstrual (PM) age in PT infants...
April 18, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29618062/45-x-46-xy-mosaicism-presenting-with-isolated-unilateral-cryptorchidism-and-a-normal-blood-karyotype
#2
Grazia Morandi, Manuela Cerbone, Elisa B Lamback, Eleni Rapti, Mehul T Dattani
Context: 45,X/46,XY mosaicism is a disorder of sex development leading to abnormal gonadal development and to unpredictable genital phenotype, growth and pubertal development. Case Description: A two year old male presented with a right impalpable testis. Blood karyotype was 46,XY. A laparoscopy performed for right orchidopexy revealed a right streak gonad with Mullerian structures, while on the left side a normal descended testis was present. The karyotype of the removed gonad was 45,X/46,XY...
March 30, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29575864/demographic-characteristics-and-amh-levels-in-rural-and-urban-women-participating-in-an-ivf-programme
#3
Michał Kunicki, Krzysztof Łukaszuk, Joanna Liss, Grzegorz Jakiel, Patrycja Skowrońska
OBJECTIVE: The primary aim of this preliminary study was to compare the IVF results of couples living in rural and urban areas. Additionally, the ovarian reserve parameters, such as AMH concentrations, were compared for the same groups. MATERIAL AND METHODS: The database of 1,265 women undergoing in vitro fertilization at the Invicta Fertility Center between May 2011-July 2012 were retrospectively analyzed. Women undergoing their first assisted reproductive technology cycle with ICSI, stimulated according to the long protocol, and whose AMH levels were measured using the same DSL kit, were selected...
March 14, 2018: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29546931/-granulosa-cell-ovarian-tumor-precocious-puberty-in-infant-less-than-1-year-of-age-case-report
#4
Patricia Lacourt, Julio Soto, Hana Rumié, Roger Gejman, Juan Carlos Pattillo, Cristián García, Hernán García
INTRODUCTION: Juvenile granulosa cell tumors (JGCT) are very rare, especially in infants under the age of one. The most frequent presentation is with signs of precocious puberty. OBJECTIVE: Present an in fant with peripheral precocious puberty, diagnosis of JGCT and follow up. CLINICAL CASE: 10-month-old female infant with thelarche, pubic hair and palpable abdominal mass accompanied with eleva ted levels of estradiol, very low gonadotrophins and images that show a very large ovarian mass...
December 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29535220/inhibin-is-a-novel-paracrine-factor-for-tumor-angiogenesis-and-metastasis
#5
Priyanka Singh, Laura M Jenkins, Ben Horst, Victoria Alers, Shrikant Pradhan, Prabhjot Kaur, Tapasya Srivastava, Nadine Hempel, Balázs Győrffy, Eugenia V Broude, Nam Y Lee, Karthikeyan Mythreye
Inhibin is a heterodimeric TGF-β family ligand that is expressed in many cancers and is a selective biomarker for ovarian cancers, however its tumor-specific functions remain unknown. Here we demonstrate that the α subunit of Inhibin (INHA), which is critical for the functionality of dimeric Inhibin A/B, correlates with microvessel density (MVD) in human ovarian tissues and xenografts and is predictive of poor clinical outcomes in multiple cancers. We demonstrate that Inhibin regulated angiogenesis is necessary for metastasis...
March 13, 2018: Cancer Research
https://www.readbyqxmd.com/read/29514896/semen-quality-in-patients-with-pituitary-disease-and-adult-onset-hypogonadotropic-hypogonadism
#6
Mikkel Andreassen, Anders Juul, Ulla Feldt-Rasmussen, Niels Joergensen
Gonadotropins (luteinizing hormone (LH) and follicle stimulating hormone (FSH)) are released from the pituitary gland and stimulate Leydig cells to produce testosterone and initiates spermatogenesis. Little is known about how and when the deterioration of semen quality occurs in patients with adult onset gonadotropin insufficiency Design and methods: A retrospective study comprising 20 testosterone deficient men (median age 29 years) with acquired pituitary disease, who delivered semen for cryopreservation before initiation of testosterone therapy...
March 7, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29509595/25-hydroxyvitamin-d-25-oh-d-and-biomarkers-of-ovarian-reserve
#7
Anne Marie Z Jukic, Donna D Baird, Allen J Wilcox, Clarice R Weinberg, Anne Z Steiner
OBJECTIVE: The aim of the study was to examine the associations between 25-hydroxyvitamin D (25(OH)D) and biomarkers of ovarian reserve in a large community-based sample of women. METHODS: In 2010 to 2016, women aged 30 to 44 years without any known fertility problems were recruited from the Chapel Hill, NC area for a prospective time-to-pregnancy cohort study. At enrollment 561 women provided a blood sample that was used to measure 25(OH)D, anti-Müllerian hormone (AMH), follicle-stimulating hormone, and inhibin-B...
March 5, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29496177/berberine-reinforces-sertoli-cells-niche-and-accelerates-spermatogonial-stem-cells-renewal-in-experimentally-induced-varicocele-condition-in-rats
#8
Hamid Rashtbari, Mazdak Razi, Hassan Hassani-Bafrani, Hamed Najaran
BACKGROUND: Varicocele is present in 10-20% of the male infertile population. PURPOSE: Present study was done to demonstrate the reinforcing effect of berberine (BBR), as an antioxidant and anti-inflammatory agent, on Sertoli cells-related niche and spermatogonial stem cells (SSCs) self-renewal in experimentally-induced VCL condition. STUDY DESIGN: 50 mature male Wistar rats were divided into control, control-sham, non-treated VCL-induced, 50 mg kg-1 and 100 mg kg-1 BBR-treated VCL-induced groups...
February 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29471860/urinary-phthalate-metabolites-in-relation-to-serum-anti-m%C3%A3-llerian-hormone-and-inhibin-b-levels-among-women-from-a-fertility-center-a-retrospective-analysis
#9
Yao-Yao Du, Na Guo, Yi-Xin Wang, Xiang Hua, Tao-Ran Deng, Xue-Mei Teng, Yang-Cheng Yao, Yu-Feng Li
BACKGROUND: Phthalates, a class of endocrine disruptors, have been demonstrated to accelerate loss of ovarian follicle pool via disrupting folliculogenesis, and lead to diminished ovarian reserve. However, human data are limited. Here, we aimed to examine whether urinary phthalate metabolites are correlated with markers of ovarian reserve among women attending a fertility clinic. METHODS: We measured eight phthalate metabolites in urine samples collected from 415 women seeking infertility treatment at the Reproductive Medicine Center of Tongji Hospital, Wuhan, China...
February 23, 2018: Reproductive Health
https://www.readbyqxmd.com/read/29471425/foxl2c134w-induced-cyp19-expression-via-cooperation-with-smad3-in-hgrc1-cells
#10
Martina Belli, Nahoko Iwata, Tomoko Nakamura, Akira Iwase, Dwayne Stupack, Shunichi Shimasaki
Germline knockout studies in female mice demonstrated an essential role for FOXL2 in early follicle development, while an inducible granulosa cell (GC) specific deletion of Foxl2 in adults has shown ovary-to-testis somatic sex reprogramming. In women, over 120 different germline mutations in the FOXL2 gene have been shown to cause blepharophimosis/ptosis/epicantus inversus syndrome associated with or without primary ovarian insufficiency. By contrast, a single somatic mutation (FOXL2C134W) accounts for almost all adult-type GC tumors (aGCTs)...
February 19, 2018: Endocrinology
https://www.readbyqxmd.com/read/29456864/curative-gnrha-treatment-has-an-unexpected-repressive-effect-on-sertoli-cell-specific-genes
#11
Katharina Gegenschatz-Schmid, Gilvydas Verkauskas, Philippe Demougin, Vytautas Bilius, Darius Dasevicius, Michael B Stadler, Faruk Hadziselimovic
Background: Follicle stimulating hormone and testosterone stimulate Sertoli cells to support germ cell function and differentiation. During mini-puberty, when gonadotropin (GnRH) stimulates increases in plasma luteinizing hormone (LH) and testosterone levels, gonocytes are transformed into Ad spermatogonia. In cryptorchidism, impaired gonadotropin secretion during mini-puberty results in insufficient LH and testosterone secretion, impaired gonocyte transition to Ad spermatogonia, and perturbed Sertoli cell proliferation...
2018: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/29449081/urinary-concentrations-of-benzophenone-type-ultra-violet-light-filters-and-reproductive-parameters-in-young-men
#12
Evdochia Adoamnei, Jaime Mendiola, Miriam Moñino-García, Fernando Vela-Soria, Luz M Iribarne-Durán, Mariana F Fernández, Nicolás Olea, Niels Jørgensen, Shanna H Swan, Alberto M Torres-Cantero
BACKGROUND: Benzophenone (BP)-type ultraviolet (UV) light filters are chemicals frequently added to personal care products, insect repellents, sunscreens, and beverage and food packaging to diminish the harmful effects of UV sunlight on human skin or foodstuffs. BP-type UV filters have shown negative effects on male reproduction function in in vitro and animal models, but human epidemiologic studies are limited. The goal of this study was to examine associations between urinary concentrations of BP-type UV filters and semen quality and reproductive hormone levels...
February 9, 2018: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29446833/body-fat-content-fat-distribution-and-adipocytokine-production-and-their-correlation-with-fertility-markers-in-young-adult-men-and-women-conceived-by-icsi
#13
F Belva, J De Schepper, M Roelants, H Tournaye, M Bonduelle, S Provyn
OBJECTIVE: Differences in body fat content during childhood and adolescence have been described in offspring conceived by In Vitro Fertilisation (IVF) and Intracytoplasmic Sperm Injection (ICSI). However, data on body fat and its distribution as well as on adipocytokine production in young adults conceived by ICSI are non-existent. We investigated if young adult men and women conceived by ICSI have a normal body fat patterning and adipocytokine production. DESIGN: Cohort study...
February 15, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29420188/human-3beta-hydroxysteroid-dehydrogenase-deficiency-associated-with-normal-spermatic-numeration-despite-a-severe-enzyme-deficit
#14
Bruno Donadille, Muriel Houang, Irene Netchine, Jean-Pierre Siffroi, Sophie Christin-Maitre
Human 3 beta-hydroxysteroid dehydrogenase deficiency (3b-HSD) is a very rare form of congenital adrenal hyperplasia resulting from HSD3B2 gene mutations. Its estimated prevalence is less than 1/1,000,000 male neonates. It leads to steroidogenesis impairment in both adrenals and gonads. Few data are available on adult testicular function in such patients. Therefore, we evaluated gonadal axis and testicular function in a 46,XY adult patient, carrying a HSD3B2 mutation. The patient presented at birth with neonatal salt wasting syndrome, a micropenis, perineal hypospadias and intrascrotal testes...
February 2, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29409132/leydig-cell-insufficiency-in-hypospermatogenesis-a-paracrine-effect-of-activin-inhibin-signaling
#15
REVIEW
S J Winters, J P Moore, B J Clark
Clinical findings and a variety of experimental models indicate that Leydig cell dysfunction accompanies damage to the seminiferous tubules with increasing severity. Most studies support the idea that intratesticular signaling from the seminiferous tubules to Leydig cells regulates steroidogenesis, which is disrupted when hypospermatogenesis occurs. Sertoli cells seem to play a pivotal role in this process. In this review, we summarize relevant clinical and experimental observations and present evidence to support the hypothesis that testicular activin signaling and its regulation by testicular inhibin may link seminiferous tubular dysfunction to reduced testosterone biosynthesis...
February 6, 2018: Andrology
https://www.readbyqxmd.com/read/29408984/postnatal-changes-in-testicular-position-are-associated-with-igf-i-and-function-of-sertoli-and-leydig-cells
#16
Jaakko J Koskenniemi, Helena E Virtanen, Christine Wohlfahrt-Veje, Eliisa Löyttyniemi, Niels E Skakkebaek, Anders Juul, Anna-Maria Andersson, Katharina M Main, Jorma Toppari
Context: Despite clinical guidelines calling for repetitive examination of testicular position during childhood, little is known of normal changes in testicular position during childhood, let alone factors that control it. Objective: To assess changes in, and factors associated with testicular position during childhood. Design: Testicular position (the distance from the pubic bone to the upper pole of the testes) at birth, 3 months, 18 months, 36 months, 7 years and reproductive hormones at three months were measured...
February 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29378377/anti-mullerian-hormone-and-inhibin-b-levels-in-obese-boys-relations-with-cardiovascular-risk-factors
#17
Muammer Buyukinan, Muge Atar, Ozgur Pirgon, Huseyin Kurku, S Sami Erdem, Isa Deniz
OBJECTIVE: Obesity may reduce sertoli cell functions in men. The aim of the study was to investigate antimullerian hormone (AMH) and inhibin B levels (sertoli cell markers) in obese boys and their relations to cardiovascular risk factors such as insulin sensitivity index, aortic intima media thickness (aIMT) and high sensitive c-reactive protein (hsCRP). PATIENTS, METHODS: 121 obese and 38 healthy lean adolescents were included in the study. Serum AMH, inhibin B, gonadotropins, total testosterone, lipids, hsCRP, glucose and insulin levels were detected and analyzed...
January 29, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29371337/endocrine-and-metabolic-evaluation-of-classic-klinefelter-syndrome-and-high-grade-aneuploidies-of-sexual-chromosomes-with-male-phenotype-are-they-different-clinical-conditions
#18
Matteo Spaziani, Benedetta Mileno, Fabio Rossi, Simona Granato, Natascia Tahani, Antonella Anzuini, Andrea Lenzi, Antonio F Radicioni
OBJECTIVE: Klinefelter syndrome (KS) is the most common sex chromosome aneuploidy in males. As well as classic KS, less frequent higher-grade aneuploidies (HGAs) are also possible. While KS and HGAs both involve testicular dysgenesis with hypergonadotropic hypogonadism, they differ in many clinical features. The aim of this study was to investigate the endocrinal and metabolic differences between KS and HGAs. DESIGN: Cross-sectional, case-control study. METHODS: 88 patients with KS, 24 with an HGA and 60 healthy controls...
April 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29354933/-clinical-therapeutic-effects-of-acupuncture-combined-with-chinese-herbal-medicine-on-infertility-of-polycystic-ovary-syndrome-in-the-patients-with-ovulation-induction-with-letrozole
#19
Yan Yin, Yingchun Zhang, Hua Zhang, Duosheng Jiang, Guirong Guo
OBJECTIVE: To evaluate the clinical therapeutic effects and safety on infertility of polycystic ovary syndrome (PCOS) in the patients with ovulation induction with letrozole in the treatment with the formula for regulating menstruation and removing phlegm and electroacupuncture (EA). METHODS: A total of 120 patients of PCOS infertility were randomized into 3 groups, 40 cases in each one. In the group A, diane-35 was prescribed for oral administration (one tablet a day since the 5th day of menstruation, continuously for 21 days)...
January 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29334660/global-proteomic-analysis-of-water-buffalo-bubalus-bubalis-saliva-at-different-stages-of-estrous-cycle-using-high-throughput-mass-spectrometry
#20
N G Shashikumar, R K Baithalu, S Bathla, S A Ali, P Rawat, A Kumaresan, S Kumar, B R Maharana, G Singh, D S Puneeth Kumar, S K Singh, S S Lathwal, L Jaiswal, T K Mohanty, A K Mohanty
Accurate and efficient detection of estrus is one of the major constraints for exploitation of the production potential of buffalo owing to its poor manifestation of estrus signs, seasonal differences in expression and higher incidences of silent estrus (29%). The current study focused on identification of estrus specific candidate proteins in saliva of buffaloes. Estrus was detected based on behavioral signs in response to the teaser and changes in reproductive organs and confirmed by per-rectal examination, trans-rectal USG of reproductive organs, cervico-vaginal mucus characteristics and blood serum progesterone estimation...
April 1, 2018: Theriogenology
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