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atopic dermatitis in children

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https://www.readbyqxmd.com/read/28523849/validation-of-a-parent-reported-diagnostic-instrument-in-a-u-s-referral-population-the-childhood-eczema-questionnaire
#1
Sabra Leitenberger, Tamar Hajar, Eric L Simpson, Laura von Kobyletzki, Jon M Hanifin
BACKGROUND/OBJECTIVES: There is a paucity of validated tools for diagnosing atopic dermatitis (AD) in very young children that do not rely on clinical evaluation. The Childhood Eczema Questionnaire (CEQ)-a diagnostic tool for AD in children younger than 2 years that a caretaker can complete-was recently validated in Sweden. The objective of this study was to validate the tool in a U.S. POPULATION: As a substudy, we added an additional question that was independently assessed...
May 19, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28521317/mechanisms-of-tolerance-induction
#2
Anna Nowak-Węgrzyn, Pantipa Chatchatee
Food allergy results from failure in oral tolerance that usually occurs in infancy or early childhood. Exposure to peanut and hen's egg via the inflamed and disrupted epithelial barrier in children with severe atopic dermatitis is a risk factor for the development of allergy to these foods and supports the hypothesis that epicutaneous exposure in the absence of oral feeding is an important pathway of allergic IgE sensitization in infants. In recent years, the collective evidence has pointed toward the protective effect of an early feeding with peanut and egg in children with eczema, taking advantage of the pathways underlying oral tolerance to counteract epicutaneous exposure...
May 19, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28512681/evaluation-of-immune-indices-and-serum-vitamin-d-content-in-children-with-atopic-dermatitis
#3
Agnieszka Lipińska-Opałka, Agata Wawrzyniak, Sławomir Lewicki, Robert Zdanowski, Bolesław Kalicki
The influence of vitamin D on allergic diseases, including atopic dermatitis, is linked to the presence of vitamin D nuclear receptors in immune cells. The present study seeks to determine the possible relationship between serum vitamin D content and immune indices in children with atopic dermatitis. The study was conducted in 19 children with atopic dermatitis. The control consisted of 17 age-matched healthy children. A single significant finding was a distinctly lower number of serum regulatory T cells in atopic dermatitis compared with controls (p < 0...
May 17, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28511614/a-new-topical-panthenol-containing-emollient-for-maintenance-treatment-of-childhood-atopic-dermatitis-results-from-a-multicenter-prospective-study
#4
Hans Stettler, Peter Kurka, Johannes Kandzora, Viktoria Pavel, Marion Breuer, Anna Macura-Biegun
PURPOSE: A study was conducted with a new topical panthenol-containing emollient (NTP-CE) to investigate the efficacy and safety of a 3-month maintenance treatment in infants and children with stabilized mild atopic dermatitis (AD). METHODS: After the stabilization phase (up to 2 months) using a corticosteroid-free topical medical device, 108 subjects (aged 2-49 months) with a SCORing AD (SCORAD) on the target area of < 5, were randomized to receive NTP-CE (N = 52) or reference emollient (N = 56) twice-daily for approximately 3 months...
May 17, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28507494/sleep-patterns-of-young-children-with-newly-diagnosed-atopic-dermatitis
#5
Derya Gumus Dogan, Sinem Kortay Canaloglu, Meltem Kivilcim, Yunus Emre Kum, Erdem Topal, Ferhat Catal
INTRODUCTION: Even though atopic dermatitis (AD) most often begins in the first year of life, it is not well known whether sleep disturbances occur following the onset of the disease or whether they develop later. AIM: To determine the sleep patterns of young children already diagnosed with AD in comparison to a control group by using a validated questionnaire, the Brief Infant Sleep Questionnaire (BISQ). MATERIAL AND METHODS: Forty-six children with a new diagnosis of AD and 60 healthy children, aged 3-36 months, participated in the study...
April 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28507230/computational-design-of-treatment-strategies-for-proactive-therapy-on-atopic-dermatitis-using-optimal-control-theory
#6
Panayiotis Christodoulides, Yoshito Hirata, Elisa Domínguez-Hüttinger, Simon G Danby, Michael J Cork, Hywel C Williams, Kazuyuki Aihara, Reiko J Tanaka
Atopic dermatitis (AD) is a common chronic skin disease characterized by recurrent skin inflammation and a weak skin barrier, and is known to be a precursor to other allergic diseases such as asthma. AD affects up to 25% of children worldwide and the incidence continues to rise. There is still uncertainty about the optimal treatment strategy in terms of choice of treatment, potency, duration and frequency. This study aims to develop a computational method to design optimal treatment strategies for the clinically recommended 'proactive therapy' for AD...
June 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28501261/obsessive-compulsive-symptoms-and-quality-of-life-in-mothers-of-children-with-atopic-dermatitis
#7
S Gunduz, E Usak, S Ozen, C Gorpelioglu
BACKGROUND AND OBJECTIVES: Atopic dermatitis is one of the most common skin disorders in children and it can negatively affect both children and their families. The purpose of this study was to investigate the effect of atopic dermatitis on quality of life related to maternal health and maternal obsessive compulsive symptoms. METHODS: A cross-sectional study was conducted in the pediatric and dermatology polyclinics. The SCORAD index was used for determining the severity of disease, and the Maudsley Obsessive Compulsive Inventory (MOCI) and SF-36 form were applied to the participants' mothers...
May 10, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28497917/does-breast-feeding-relate-to-development-of-atopic-dermatitis-in-young-korean-children-based-on-the-fourth-and-fifth-korea-national-health-and-nutrition-examination-survey-2007-2012
#8
Kyung Suk Lee, Yeong Ho Rha, In Hwan Oh, Yong Sung Choi, Young Eun Kim, Sun Hee Choi
PURPOSE: There have been conflicting reports concerning the relationship between breast-feeding and the development of atopic dermatitis (AD) in early childhood. The objective of this study was to investigate the associations between breast-feeding and the risk of AD in early childhood in Korea. METHODS: We combined the fourth and fifth Korea National Health and Nutrition Examination Survey data collected from 2007 to 2012 and analyzed 2,015 children at 1 to 3 years old...
July 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28492291/crisaborole-phosphodiesterase-inhibitor-for-treatment-of-atopic-dermatitis
#9
D M Paton
Atopic dermatitis (AD) is an extremely common condition affecting as many as 10-20% of children and 2-10% of adults. A particularly distressing symptom of AD is pruritus. One of the important aspects of AD is inflammation associated with increased activity of phosphodiesterase 4 (PDE4), resulting in decreased intracellular levels of cyclic adenosine monophosphate, which in turn causes increased production of inflammatory cytokines. Crisaborole was developed as a small-molecule, boron-based, selective PDE4 inhibitor that can be used topically...
April 2017: Drugs of Today
https://www.readbyqxmd.com/read/28484688/what-are-the-effects-of-a-mediterranean-diet-on-allergies-and-asthma-in-children
#10
REVIEW
Jose A Castro-Rodriguez, Luis Garcia-Marcos
This review updates the relationship between the adherence to Mediterranean diet (MedDiet) assessed by questionnaire and asthma, allergic rhinitis, or atopic eczema in childhood. It deals with the effect of MedDiet in children on asthma/wheeze, allergic rhinitis, and atopic dermatitis/eczema, and also with the effect of MedDiet consumption by the mother during pregnancy on the inception of asthma/wheeze and allergic diseases in the offspring. Adherence to MedDiet by children themselves seems to have a protective effect on asthma/wheezing symptoms after adjustment for confounders, although the effect is doubtful on lung function and bronchial hyperresponsiveness...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28470762/contact-allergy-in-children-with-atopic-dermatitis-a-systematic-review
#11
REVIEW
A B Simonsen, J D Johansen, M Deleuran, C G Mørtz, M Sommerlund
The importance of contact allergy in children with atopic dermatitis is frequently debated. Previously, patients with atopic dermatitis were believed to have a reduced ability to produce a type IV immunologic response. However, this belief has been challenged and authors have highlighted the risk of underestimating and overlooking allergic contact dermatitis in children with atopic dermatitis. Several studies have been published aiming to shed light on this important question but results are contradictory. To provide an overview of the existing knowledge, we systematically reviewed studies that report frequencies of positive patch test reactions in children with atopic dermatitis...
May 3, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28465037/is-there-any-difference-regarding-atopy-between-children-with-familial-mediterranean-fever-and-healthy-controls
#12
Ç Aydoğmuş, N A Ayaz, M Çakan, F Çipe, N Topal, Ö B Öner, G Keskindemirci, A Akçay
INTRODUCTION: There are only a few studies regarding the prevalence of atopy in Familial Mediterranean fever (FMF) patients, and their results are conflicting. METHODS: In this study children with the diagnosis of FMF were evaluated for the presence of atopy by comparing with controls. One hundred and eighteen children diagnosed as FMF and 50 healthy age and sex matched controls were enrolled. They were evaluated for the presence of rhinitis, atopic dermatitis, urticaria and asthma...
April 29, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28456621/ige-sensitization-in-relation-to-preschool-eczema-and-filaggrin-mutation
#13
Emma Kristin Johansson, Anna Bergström, Inger Kull, Tomas Lind, Cilla Söderhäll, Marianne van Hage, Magnus Wickman, Natalia Ballardini, Carl-Fredrik Wahlgren
BACKGROUND: Eczema (atopic dermatitis) is associated with an increased risk of having IgE antibodies. IgE sensitization may occur through an impaired skin barrier. Filaggrin (FLG) mutation is associated with eczema, and possibly also with IgE sensitization. OBJECTIVE: To explore the longitudinal relation between preschool eczema and/or FLG mutation and IgE sensitization in childhood. METHODS: A total of 3201 children from the BAMSE birth cohort recruited from the general population were included...
April 26, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28452068/an-evaluation-of-vitamin-d-levels-in-children-with-seasonal-allergic-rhinitis-during-pollen-season
#14
Şeyhan Kutluğ, Mehtap Kılıç, Birşen Bilgici, Şule Paksu, Alişan Yıldıran, Recep Sancak
BACKGROUND: Serum vitamin D levels have not been studied in children with seasonal allergic rhinitis (SAR). The aim of this study was to evaluate the vitamin D levels of children with SAR and to compare them to levels in healthy children during pollen season. METHODS: This study was conducted in 100 children with SAR and 100 healthy controls. Clinical and laboratory evaluations and vitamin D analyses of all the participants were performed between the months of April and July...
April 27, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28443596/lack-of-association-between-toll-like-receptor-2-polymorphisms-r753q-and-a-16934t-and-atopic-dermatitis-in-children-from-thrace-region-of-turkey
#15
Can Ceren, Mehtap Yazıcıoğlu, Hakan Gürkan, Adnan Görgülü, Necdet Süt
BACKGROUND: Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. A complex interaction of both genetic and environmental factors is thought to contribute to the disease. Recently relations between single nucleotide polymorphisms (SNPs) of toll-like receptors (TLRs) and AD have been reported. AIMS: The aim of the study was to evaluate whether SNPs in the TLR2 gene c.2258C>T (R753Q) (rs5743708) and TLR2 c.-148+1614T>A (A-16934T) (rs4696480) (NM_0032643) are associated with AD in Turkish children...
April 6, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28432437/an-italian-multicentre-study-on-adult-atopic-dermatitis-persistent-versus-adult-onset-disease
#16
Matteo Megna, Cataldo Patruno, Anna Balato, Franco Rongioletti, Luca Stingeni, Nicola Balato
Atopic dermatitis (AD) is a chronic, recurrent, inflammatory skin disease which predominantly affects children. However, AD may persist until adulthood (persistent AD), or directly start in adults (adult-onset AD). AD often shows a non-flexural rash distribution, and atypical morphologic variants in adults and specific diagnostic criteria are lacking. Moreover, adult AD prevalence as well as detailed data which can characterize persistent vs adult-onset subtype are scant. The aim of this study was to investigate on the main features of adult AD particularly highlighting differences between persistent vs adult-onset form...
April 21, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28431963/expansion-of-circulating-follicular-t-helper-cells-associates-with-disease-severity-in-childhood-atopic-dermatitis
#17
Krisztina Szabó, Krisztián Gáspár, Zsolt Dajnoki, Gábor Papp, Beáta Fábos, Andrea Szegedi, Margit Zeher
Follicular helper T (TFH) cells play crucial role in B-cell differentiation and antibody production. Although, atopic dermatitis (AD) is often associated with increased serum IgE levels, B-cell mediated responses have not been studied thoroughly. The aim of our study was to investigate the proportion of TFH-like cells in the disease. Twelve children and 17 adults with AD as well as 14 healthy controls were enrolled in the study. The frequency of CD4(+)CXCR5(+)ICOS(+)PD-1(+) TFH-like cells and their IL-21 cytokine production were determined by flow cytometry...
April 18, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28426906/measuring-the-impact-of-dermatological-conditions-on-family-and-caregivers-a-review-of-dermatology-specific-instruments
#18
REVIEW
F Sampogna, A Y Finlay, S S Salek, P Chernyshov, F J Dalgard, A W M Evers, D Linder, L Manolache, S E Marron, F Poot, S Spillekom-van Koulil, Å Svensson, J C Szepietowski, L Tomas-Aragones, D Abeni
The patient is the centre of a web of relationships and the impact of his/her disease on family members and caregivers must be taken into account. The aim of this study was to identify the specific instruments that measure the impact of a dermatological disease on the quality of life (QoL) of family members, by performing a systematic search of the literature. Fifteen papers were identified, describing the creation and validation of nine instruments. Four of them concerned atopic dermatitis (Dermatitis Family Index, DFI; Parents' Index QoL Atopic Dermatitis, PiQoL-AD; QoL in Primary Caregivers of children with Atopic Dermatitis, QPCAD; Childhood Atopic Dermatits Impact Scale, CADIS), two measured the impact of psoriasis in family members (Psoriasis Family Index, PFI; FamilyPso), one the impact of epidermolysis bullosa (Epidermolysis Bullosa Burden of Disease, EB-BoD), one of ichthyosis (Family Burden Ichthyosis, FBI), and one was generic for dermatological conditions (Family Dermatology Life Quality Index, FDLQI)...
April 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28425237/the-efficacy-of-narrowband-uvb-treatment-in-pediatricvitiligo-a-retrospective-analysis-of-26-cases
#19
Serkan Yazici, Berrin Günay, Emel Bülbül Başkan, Kenan Aydoğan, Hayriye Saricaoğlu, Şükran Tunali
BACKGROUND/AIM: Narrowband UVB (Nb UVB) treatment is commonly used for the management of psoriasis and atopic dermatitis, and is less often used for vitiligo in children. The aim of this study was to evaluate the efficacy and short-term safety of Nb UVB phototherapy in children diagnosed with vitiligo retrospectively. MATERIALS AND METHODS: A total of 26 patients younger than 18 years with the diagnosis of vitiligo and managed with Nb UVB phototherapy as documented in archive records were evaluated...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28409557/randomised-controlled-trial-of-silk-therapeutic-garments-for-the-management-of-atopic-eczema-in-children-the-clothes-trial
#20
Kim S Thomas, Lucy E Bradshaw, Tracey H Sach, Fiona Cowdell, Jonathan M Batchelor, Sandra Lawton, Eleanor F Harrison, Rachel H Haines, Amina Ahmed, Taraneh Dean, Nigel P Burrows, Ian Pollock, Hannah K Buckley, Hywel C Williams, Joanne Llewellyn, Clare Crang, Jane D Grundy, Juliet Guiness, Andrew Gribbin, Eileen V Wake, Eleanor J Mitchell, Sara J Brown, Alan A Montgomery
BACKGROUND: Atopic eczema (AE) is a chronic, itchy, inflammatory skin condition that affects the quality of life of children and their families. The role of specialist clothing in the management of AE is poorly understood. OBJECTIVES: To assess the effectiveness and cost-effectiveness of silk garments for the management of AE in children with moderate to severe disease. DESIGN: Parallel-group, observer-blind, randomised controlled trial of 6 months' duration, followed by a 2-month observational period...
April 2017: Health Technology Assessment: HTA
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