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atopic dermatitis in children

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https://www.readbyqxmd.com/read/28346719/reduced-th22-cell-proportion-and-prevention-of-atopic-dermatitis-in-infants-following-maternal-probiotic-supplementation
#1
Anne Dorthea Bjerkenes Rø, Melanie Rae Simpson, Torstein Baade Rø, Ola Storrø, Roar Johnsen, Vibeke Videm, Torbjørn Øien
In the randomized, controlled study Probiotics in the Prevention of Allergy among Children in Trondheim (ProPACT), maternal probiotic supplementation reduced the incidence of atopic dermatitis (AD) in the offspring. In the current study, we hypothesized that the effect was mediated by a shift in the T helper (Th) cells in the children. OBJECTIVE: To examine whether Th cell proportions were affected by maternal probiotic supplementation and thus could mediate the preventive effect of probiotics on AD...
March 27, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28333952/adjuvant-treatment-with-the-bacterial-lysate-om-85-improves-management-of-atopic-dermatitis-a-randomized-study
#2
Christine Bodemer, Gerard Guillet, Frederic Cambazard, Franck Boralevi, Stefania Ballarini, Christian Milliet, Paola Bertuccio, Carlo La Vecchia, Jean-François Bach, Yves de Prost
BACKGROUND: Environmental factors play a major role on atopic dermatitis (AD) which shows a constant rise in prevalence in western countries over the last decades. The Hygiene Hypothesis suggesting an inverse relationship between incidence of infections and the increase in atopic diseases in these countries, is one of the working hypothesis proposed to explain this trend. OBJECTIVE: This study tested the efficacy and safety of oral administration of the bacterial lysate OM-85 (Broncho-Vaxom®, Broncho-Munal®, Ommunal®, Paxoral®, Vaxoral®), in the treatment of established AD in children...
2017: PloS One
https://www.readbyqxmd.com/read/28330497/atopic-dermatitis-anti-ige-paediatric-trial-adapt-the-role-of-anti-ige-in-severe-paediatric-eczema-study-protocol-for-a-randomised-controlled-trial
#3
Susan Chan, Victoria Cornelius, Tao Chen, Suzana Radulovic, Mandy Wan, Rahi Jahan, Gideon Lack
BACKGROUND: The evidence for systemic treatments for severe childhood eczema is limited and largely based on extrapolation of data from adult studies. Current therapies are often immunosuppressant and may be associated with both short- and long-term side effects. There is increasing in vitro and murine-model evidence for the role of IgE in the immunopathogenesis of atopic eczema. The aim of the study is to assess whether anti-IgE treatment (omalizumab) improves eczema, compared to placebo...
March 22, 2017: Trials
https://www.readbyqxmd.com/read/28329641/differences-in-incidence-and-persistence-of-atopic-dermatitis-by-race-ethnicity
#4
M Blomberg, S L Rifas-Shiman, Ca Jr Camargo, D R Gold, J P Thyssen, A A Litonjua, M W Gillman, M M Asgari, E Oken
BackgroundMost studies on racial disparities in childhood atopic dermatitis (AD) did not consider persistent AD or account for differences in vitamin D status.MethodsAmong 1418 children recruited from a Massachusetts HMO into the pre-birth Project Viva cohort, we examined associations of child's race/ethnicity with maternal report of child's AD diagnosis by annual questionnaires. We used multivariable logistic regression adjusted for socio- demographics (maternal education, household income, smoking exposure, parental atopy, breastfeeding duration, child sex) and cord blood 25-hydroxyvitamin D, to estimate odds ratios (OR) of incident AD by early childhood (median age 3...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329627/association-of-atopic-dermatitis-with-tobacco-smoke-exposure-a-systematic-review-and-meta-analysis
#5
Robert Kantor, Ashley Kim, Jacob Thyssen, Jonathan I Silverberg
Previous studies found conflicting results about whether exposure to tobacco smoke is associated with increased atopic dermatitis (AD). We examined this association by systematic review and meta-analysis of MEDLINE, EMBASE, Scopus, and Cochrane Library and identified 86 studies, including 680,176 patients from 39 countries. A meta-analysis was performed using random-effects models to estimate pooled odds ratios (OR). Subset analyses were performed for different ages (children or adult), regions, study designs (cross-sectional vs...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28318051/atopic-dermatitis-in-israeli-adolescents-from-1998-to-2013-trends-in-time-and-association-with-migraine
#6
Rony Shreberk-Hassidim, Ayal Hassidim, Yoav Gronovich, Adam Dalal, Vered Molho-Pessach, Abraham Zlotogorski
BACKGROUND: Recent data have shown an increasing occurrence of atopic dermatitis (AD) in children and adolescents, as well as in adults. Most of the epidemiologic research on AD is limited to pediatric and youth populations and is based on self-reported questionnaires. METHODS: A nationwide, population-based, cross-sectional retrospective study of adolescents with AD was performed to estimate its prevalence, trends, and association with demographic factors and comorbidities...
March 20, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28300440/review-of-atopic-dermatitis-and-topical-therapies
#7
Julia N Mayba, Melinda J Gooderham
Atopic dermatitis is one of the most common skin disorders in the developed world, affecting up to 20% of children and 1% to 3% of adults. This review concisely explains the pathophysiology and epidemiology of atopic dermatitis, as well as potential challenges facing its successful treatment. Furthermore, mainstay topical treatment modalities are evaluated, such as emollients, topical corticosteroids, and topical calcineurin inhibitors. The use of topical corticosteroids and topical calcineurin inhibitors in combination is discussed, as studies have indicated encouraging results...
December 1, 2016: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28281298/children-with-atopic-dermatitis-and-frequent-emollient-use-have-increased-urinary-levels-of-low-molecular-weight-phthalate-metabolites-and-parabens
#8
Line E K Overgaard, Katharina M Main, Hanne Frederiksen, Steen Stender, Pal B Szecsi, Hywel C Williams, Jacob P Thyssen
BACKGROUND: Parabens may be added to cosmetic and personal care products for preservation purposes. Low-molecular weight (LMW) phthalate diesters function as plasticizers, fixatives or solvents in such products, but may also be found in small quantities as contaminants from plastic containers. OBJECTIVE: To evaluate the association between emollient use, atopic dermatitis and FLG mutations, respectively, with urinary concentrations of phthalate metabolites and parabens in Danish children...
March 9, 2017: Allergy
https://www.readbyqxmd.com/read/28279075/establishing-a-role-for-interleukin-17-in-atopic-dermatitis-related-skin-inflammation
#9
Qi Tan, Huan Yang, En-Mei Liu, Hua Wang
BACKGROUND: Although CD4(+) T cells are known to contribute to the pathology of atopic dermatitis (AD), the role of T helper 17 cells and interleukin (IL)-17 in skin inflammation remains poorly understood. The aim of this study was to characterize the role of IL-17 in AD-related inflammation and immunopathology. METHODS: Blood samples were collected from 87 children with AD and 60 healthy control subjects. In addition, 10 skin biopsies from each group were collected...
March 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28276107/prenatal-antibiotics-and-atopic-dermatitis-among-18-month-old-children-in-the-danish-national-birth-cohort
#10
Signe Timm, Vivi Schlünssen, Jørn Olsen, Cecilia Høst Ramlau-Hansen
BACKGROUND: Despite extensive research, the aetiology of atopic dermatitis remains largely unknown, but reduced intestinal microbiota diversity in neonates has been linked to subsequent atopic dermatitis. Consequently, postnatal antibiotics have been proposed as a risk factor, but a potential association between prenatal antibiotics and atopic dermatitis is not well studied. Overall, the current evidence suggests a positive association between exposure to prenatal antibiotics and atopic dermatitis...
March 9, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28274229/exposure-to-phthalates-and-bisphenol-a-are-associated-with-atopic-dermatitis-symptoms-in-children-a-time-series-analysis
#11
Eun-Hye Kim, Byoung-Hak Jeon, Jihyun Kim, Young-Min Kim, Youngshin Han, Kangmo Ahn, Hae-Kwan Cheong
BACKGROUND: Despite increasing evidence on the relationship between exposure to phthalates and bisphenol A with allergies and asthma, reports on atopic dermatitis (AD) with these chemicals are few. We assessed the association between AD symptoms and the exposure to phthalates and bisphenol A and in children. METHODS: We surveyed 18 boys with AD (age 3-7 years) in a day care center in Seoul between May 2009 and April 2010. AD symptoms were recorded by using a daily symptom diary...
March 9, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28271540/prevention-of-flares-in-children-with-atopic-dermatitis-with-regular-use-of-an-emollient-containing-glycerol-and-paraffin-a-randomized-controlled-study
#12
George Sorin Tiplica, Andrzej Kaszuba, Laura Malinauskienė, Pille Konno, Franck Boralevi, Eric Garrigue, Markéta Saint-Aroman, Alain Delarue
BACKGROUND/OBJECTIVES: Emollients are part of the standard treatment for atopic dermatitis (AD), although there is limited evidence that regular use of emollients as management therapy reduces the frequency of flares and corticosteroid consumption. The objective of this study was to evaluate the benefit of emollient use in the management of mild to moderate AD in children by assessing the ability of two different emollients (particularly V0034CR) to prevent flares and to reduce the use of corticosteroids...
March 7, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28271213/the-influence-of-probiotics-for-preterm-neonates-on-the-incidence-of-atopic-dermatitis-results-from-a-historically-controlled-cohort-study
#13
Julie A Damm, Birgitte Smith, Gorm Greisen, Karen A Krogfelt, Maja-Lisa Clausen, Tove Agner
Probiotic supplementation is a promising preventive strategy for atopic dermatitis (AD). To help clarifying the significance of timing with respect to prevention of AD, we here evaluate the benefit of prophylactic use of probiotic supplementation in neonates younger than 30 weeks of gestation. Preterm children from the Department of Neonatology, Rigshospitalet, Denmark from two different admission periods were included in a historically controlled cohort study. Neonates from January 2007 to February 2010, not treated with and neonates from March 2010 to February 2013 treated with probiotic were enrolled...
March 7, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28270741/sensitization-to-secretoglobin-and-lipocalins-in-a-group-of-young-children-with-risk-of-developing-respiratory-allergy
#14
Mizuho Nagao, Magnus P Borres, Mayumi Sugimoto, Carl Johan Petersson, Satoshi Nakayama, Yu Kuwabara, Sawako Masuda, Patrik Dykiel, Takao Fujisawa
BACKGROUND: Multiple sensitizations in early age have been reported to be a risk for development of asthma. This study evaluates the emergence and evolution of IgE to aeroallergens among a cohort of children with physician-diagnosed atopic dermatitis and/or showing food allergy symptoms and to examine the relation to asthma development. METHODS: Three-hundred and four children (median age 13.4 months at entry) with food allergy symptoms and/or atopic dermatitis without asthma at inclusion were analysed for IgE antibodies against food-, indoor- and outdoor-allergens and pet allergen components and correlated to the individuals' outcome on asthma inception...
2017: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/28259851/study-protocol-to-investigate-the-environmental-and-genetic-aetiology-of-atopic-dermatitis-the-indonesian-prospective-study-of-atopic-dermatitis-in-infants-isadi
#15
Conny Tanjung, Peter Rzehak, Muchtaruddin Mansyur, Zakiudin Munasir, Herawati Sudoyo, Suzanna Immanuel, Roedi Irawan, Eva Reischl, Hans Demmelmair, Berthold Koletzko, Sri Rezeki Hadinegoro, Damayanti Rusli Sjarif
INTRODUCTION: Atopic dermatitis (AD) is the most common skin disorder in young children worldwide, with a high impact on morbidity and quality of life. To date, no prospective study has been published on the incidence and potential predictors of AD in South East Asian populations. The Indonesian Prospective Study of Atopic Dermatitis in Infants (ISADI) will address the genetic, metabolic and dietary characteristics of mothers and their offspring, as well as potential determinants of AD within the first year of infant life...
March 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/28259687/inpatient-financial-burden-of-atopic-dermatitis-in-the-united-states
#16
Shanthi Narla, Derek Y Hsu, Jacob P Thyssen, Jonathan I Silverberg
Little is known about the inpatient burden of atopic dermatitis (AD). We sought to determine some risk factors and financial-burden of hospitalizations for AD in the US. Data were analyzed from the 2002-2012 National Inpatient Sample, including of a 20% representative sample of all hospitalizations in the US. Hospitalization rates for AD or eczema (AD-E) were highest in the northeast during the winter and south during the summer. Geometric mean cost of care [95% CI] was lower for a primary diagnosis of AD-E vs...
March 1, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28258632/methylprednisolone-aceponate-for-atopic-dermatitis
#17
Antonio Torrelo
BACKGROUND: The 4th generation topical corticosteroids (TCS) have demonstrated a most favorablerisk-benefit ratio. Methylprednisolone aceponate (MPA) is a non-halogenated corticosteroid with a methyl group at C6, which confers higher intrinsic activity. MPA is included in the group of potent TCS (category III/IV). METHODS: A literature review is carried out of the clinical efficacy, pharmacokinetics, and adverse effects of MPA, especially for the treatment of atopic dermatitis (AD)...
March 4, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28257631/clinical-practice-recommendations-for-allergen-specific-immunotherapy-in-children-the-italian-consensus-report
#18
REVIEW
Giovanni Battista Pajno, Roberto Bernardini, Diego Peroni, Stefania Arasi, Alberto Martelli, Massimo Landi, Giovanni Passalacqua, Antonella Muraro, Stefania La Grutta, Alessandro Fiocchi, Luciana Indinnimeo, Carlo Caffarelli, Elisabetta Calamelli, Pasquale Comberiati, Marzia Duse
Allergen-specific immunotherapy (AIT) is currently recognized as a clinically effective treatment for allergic diseases, with a unique disease-modifying effect. AIT was introduced in clinical practice one century ago, and performed in the early years with allergenic extracts of poor quality and definition. After the mechanism of allergic reaction were recognized, the practice of AIT was refined, leading to remarkable improvement in the efficacy and safety profile of the treatment. Currently AIT is accepted and routinely prescribed worldwide for respiratory allergies and hymenoptera venom allergy...
January 23, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28250923/prenatal-exposure-to-selenium-may-protect-against-wheezing-in-children-by-the-age-of-3
#19
Nour Baïz, Julie Chastang, Gladys Ibanez, Isabella Annesi-Maesano
INTRODUCTION: It has been suggested that human in utero exposure to heavy metals such as selenium can reduce the prevalence of childhood asthma and allergic diseases. However, data on this topic are scarce. The objective of the present study was to assess the putative associations between maternal selenium level during pregnancy and the risk of asthma, wheezing, allergic rhinitis, and atopic dermatitis in children from the EDEN birth cohort by the age of 1 and 3 years. METHODS: Plasma selenium concentrations were measured in maternal blood during mid-pregnancy (24-28 weeks of gestation) in 861 mothers...
March 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28245844/topical-corticosteroid-phobia-in-parents-of-pediatric-patients-with-atopic-dermatitis-a-multicentre-survey
#20
Maya El Hachem, Francesco Gesualdo, Giampaolo Ricci, Andrea Diociaiuti, Loredana Giraldi, Orsola Ametrano, Corrado Occella, Anna Belloni Fortina, Mirella Milioto, Fabio Arcangeli, Oriana Simonetti, Simona Giancristoforo, Elisabetta Calamelli, Carlo Mazzatenta, Iria Neri
BACKGROUND: Families of children affected with atopic dermatitis (AD) often report fear and anxiety regarding treatment with topical corticosteroids (TCS), which may lead to reduced compliance. The objective of our study was to measure, through a standardized questionnaire, fear of TCS in families of pediatric patients with AD and to identify items associated with fear. METHODS: Families of pediatric patients with AD were enrolled in 9 Italian centers of pediatric dermatology...
February 28, 2017: Italian Journal of Pediatrics
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