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atopic dermatitis in children

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https://www.readbyqxmd.com/read/29791750/tiled-array-based-sequencing-identifies-enrichment-of-loss-of-function-variants-in-the-highly-homologous-filaggrin-gene-in-african-american-children-with-severe-atopic-dermatitis
#1
Mary Elizabeth Mathyer, Ashley M Quiggle, X F Colin C Wong, Simon L I J Denil, Monique G Kumar, Heather M Ciliberto, Susan J Bayliss, John E Common, Cristina de Guzman Strong
Filaggrin (FLG) loss of function (LOF) variants are a major risk factor for the common inflammatory skin disease, atopic dermatitis (AD), and are often population-specific. African American (AA) children are disproportionately affected with AD, often later developing asthma and/or allergic rhinitis and comprise an atopy health disparity group for which the role of FLG LOF is not well known. Discovery of FLG LOF using exome sequencing is challenging given the known difficulties for accurate short-read alignment to FLG's high homology repeat variation...
May 23, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29786146/awareness-of-and-phobias-about-topical-corticosteroids-in-parents-of-infants-with-eczema-in-hangzhou-china
#2
Yunling Li, Ting Han, Wei Li, Yin Li, Xiaoxuan Guo, Lei Zheng
BACKGROUND/OBJECTIVES: Knowledge of and phobias about topical corticosteroids in parents of infants with eczema affect efficacy of eczema treatment. METHODS: We surveyed 300 parents of children with eczema using a questionnaire to investigate knowledge of and phobias about topical corticosteroids. RESULTS: Overall, 85.7% (n = 257) of children had used topical corticosteroids, with 12.8% (n = 33) of children having steroids applied for only 1-3 days per episode; 79...
May 22, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29785236/the-efficacy-of-a-ceramide-based-cream-in-mild-to-moderate-atopic-dermatitis
#3
Zoe Diana Draelos, Isabelle Raymond
Objective: The goal of this study was to determine if a therapeutic cream containing PC-104 synthetic ceramides and other ingredients could help to ameliorate signs and symptoms of mild-to-moderate atopic dermatitis and other xerotic or pruritic dermatoses. Design: In this single-site, four-week study, subjects (n=50) were instructed to apply the study product three times daily to all affected areas, including a target site for evaluation and photography at baseline, Week 2, and Week 4 visits. Setting: This study took place in the private practice of the senior author...
May 2018: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29783251/prevalence-of-risk-factors-of-allergic-diseases-among-children-aged-8-9-years-in-poltava-region-the-results-of-the-first-stage-of-the-research
#4
Tetyana O Kryuchko, Iryna A Holovanova, Olha Y Tkachenko, Mariya O Melnyk, Kateryna V Pocheniuk
OBJECTIVE: Introduction: According to the European Academy of Allergology and Clinical Immunology (EAACI, 2016), allergy is the most common chronic disease in Europe. The aim: The aim of the investigation is to study the spread of risk factors of allergic reactions in children who are 8-9 years old of Poltava region. PATIENTS AND METHODS: Materials and methods: The investigation included two stages: the 1st contained interviewing; the 2nd one - additional clinical and lab investigation of children, who require the further diagnosis specification...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29766369/nutritional-issues-in-food-allergy
#5
REVIEW
Isabel J Skypala, Rebecca McKenzie
Diet and nutrition play an important role in the development and management of food allergy. The diet of expectant mothers can have an effect on their offspring in terms of allergic outcomes. A host of confounding factors may influence this, with a maternal diet rich in fruits and vegetables, fish, vitamin D-rich foods associated with a lower risk of allergic disease in their children. More surprisingly, the consumption of milk and butter has also been shown to have a protective effect, especially in a farm environment...
May 15, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29764626/25-hydroxvitamin-d-concentrations-are-not-lower-in-children-with-bronchial-asthma-atopic-dermatitis-obesity-or-attention-deficient-hyperactivity-disorder-than-in-healthy-children
#6
Thomas Reinehr, Christian Langrock, Eckard Hamelmann, Thomas Lücke, Cordula Koerner-Rettberg, Martin Holtmann, Tanja Legenbauer, Stephanie Gest, Mirjam Frank, Börge Schmidt, Katharina Radkowski, Karl-Heinz Jöckel
Vitamin D (vitD) is involved in immune regulation, and its receptor has been identified in several tissues including lung, adipose tissue, brain, and skin. Based on these observations, it has been suggested that vitD has an essential role not only in bone metabolism but also in other diseases such as atopic dermatitis (AD), bronchial asthma (BA), attention-deficit/hyperactivity disorder (ADHD), and obesity because the affected tissues express vitD receptors. Furthermore, obesity, AD, and BA are regarded as inflammatory diseases...
April 2018: Nutrition Research
https://www.readbyqxmd.com/read/29763349/molar-incisor-hypomineralization-positive-correlation-with-atopic-dermatitis-and-food-allergies
#7
Miguel Hernandez, Juan Boj, Enric Espasa, Paloma Planells, Benjamin Peretz
AIM: Molar-incisor hypomineralization is a disturbance in dental development that involves first permanent molars as well as permanent incisors with a prevalence that ranges from 2.5% to 40%. The objective of this study was to investigate the etiology of molar-incisor hypomineralization among school children from two randomly selected towns in the province of Barcelona, Spain. STUDY DESIGN: A cross-sectional study was conducted with 705 children ranging in age from six years-old to 14 years and 11 months-old...
May 15, 2018: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29762208/prevalence-of-atopic-dermatitis-and-pattern-of-drug-therapy-in-malaysian-children
#8
Yi-Yeong Goh, Fazlollah Keshavarzi, Yik Ling Chew
BACKGROUND: Atopic dermatitis (AD) is a chronic relapsing, noncontagious skin inflammation characterized by dry skin and itch. Mutation in filaggrin gene leads to defective skin barrier, allowing entry of allergen and eliciting immunological response. OBJECTIVES: The aims of this study were to investigate the prevalence of AD in Malaysian children and to understand the pattern of drug therapy. Such information could be useful to establish the relationship between ethnicity and family history of atopy and the development of associated signs and symptoms...
May 2018: Dermatitis
https://www.readbyqxmd.com/read/29748919/severe-atopic-dermatitis-in-children
#9
REVIEW
Evie Huang, Peck Y Ong
PURPOSE OF REVIEW: Severe atopic dermatitis (AD) in childhood leads to significant morbidity including psychosocial problems and infectious complications. There are only a few approved treatment options for these patients. These include topical corticosteroids and tacrolimus ointment, which are associated with potential side effects. RECENT FINDINGS: In order to find better and safer treatments, further understanding of AD mechanisms is needed. Primary skin barrier defects play an important role in the pathogenesis of AD...
May 10, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29732975/demystifying-dysbiosis-can-the-gut-microbiome-promote-oral-tolerance-over-ige-mediated-food-allergy
#10
Tom Marrs, K Sim
The growing burden of food allergy is being driven by environmental exposures and the potential role of gut micro-organisms (or 'microbiota') is hotly debated. Early culture-based studies outlined that imbalances between commensal gut constituents ('dysbiosis') early in life may raise the risk of developing allergic disease. A number of studies using animal models describe mechanisms by which specific bacterial taxa within the gut microbiota, their diversity and dietary substrates such as fibre may promote oral tolerance...
May 7, 2018: Current Pediatric Reviews
https://www.readbyqxmd.com/read/29731195/urban-particulate-matter-in-air-pollution-penetrates-into-the-barrier-disrupted-skin-and-produces-ros-dependent-cutaneous-inflammatory-response-in-vivo
#11
Seon-Pil Jin, Zhenyu Li, Eun Kyung Choi, Serah Lee, Yoen Kyung Kim, Eun Young Seo, Jin Ho Chung, Soyun Cho
BACKGROUND: Particulate matter (PM) is an integral part of air pollution, which is a mixture of particles suspended in the air. Recently, it has been reported that PM is associated with increased risks of skin diseases, especially atopic dermatitis in children. However, it is unclear if PM directly goes into the skin and what mechanisms are involved in response to PM. OBJECTIVE: To see whether PM could penetrate into the barrier-disrupted skin, produce reactive oxygen species (ROS), and elicit an inflammatory response...
April 30, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29731129/early-onset-pediatric-atopic-dermatitis-is-characterized-by-t-h-2-t-h-17-t-h-22-centered-inflammation-and-lipid-alterations
#12
Patrick M Brunner, Ariel Israel, Ning Zhang, Alexandra Leonard, Huei-Chi Wen, Thy Huynh, Gary Tran, Sarah Lyon, Giselle Rodriguez, Supriya Immaneni, Annette Wagner, Xiuzhong Zheng, Yeriel D Estrada, Hui Xu, James G Krueger, Amy S Paller, Emma Guttman-Yassky
BACKGROUND: Although atopic dermatitis (AD) often starts in early childhood, detailed tissue profiling of early-onset AD in children is lacking, hindering therapeutic development for this patient population with a particularly high unmet need for better treatments. OBJECTIVE: We sought to globally profile the skin of infants with AD compared with that of adults with AD and healthy control subjects. METHODS: We performed microarray, RT-PCR, and fluorescence microscopy studies in infants and young children (<5 years old) with early-onset AD (<6 months disease duration) compared with age-matched control subjects and adults with longstanding AD...
April 19, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29730889/outdoor-environment-ozone-radionuclide-associated-aerosols-and-incidences-of-infantile-eczema-in-minsk-belarus
#13
I N Belugina, N Z Yagovdik, O S Belugina, S N Belugin
BACKGROUND: The early occurrence of atopic dermatitis in infants may be influenced by urban air pollution. OBJECTIVE: The aim of this study was to determine the relationship between incidences of infantile eczema in children under 2 years of age and urban outdoor environmental factors. METHODS: A 11-year population based study was conducted in retrospective design. The age/gender adjusted incidence rates of infantile eczema were determined using the data of outpatient visits...
May 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29729180/the-widespread-use-of-topical-antimicrobials-enriches-for-resistance-in-staphylococcus-aureus-isolated-from-atopic-dermatitis-patients
#14
C P Harkins, M A McAleer, D Bennett, M McHugh, O M Fleury, K A Pettigrew, K Oravcová, J Parkhill, C M Proby, R S Dawe, J A Geoghegan, A D Irvine, M T G Holden
BACKGROUND: Carriage rates of Staphylococcus aureus on affected skin in atopic dermatitis (AD) are approximately 70%. Increasing disease severity during flares and overall disease severity correlate with increased burden of S. aureus. Treatment in AD therefore often targets S. aureus, with topical and systemic antimicrobials. OBJECTIVES: To determine if antimicrobial sensitivities and genetic determinants of resistance differed in S. aureus isolates from the skin of children with AD compared with healthy child nasal carriers...
May 5, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29727479/a-randomised-controlled-trial-protocol-assessing-the-effectiveness-safety-and-cost-effectiveness-of-methotrexate-versus-ciclosporin-in-the-treatment-of-severe-atopic-eczema-in-children-the-treatment-of-severe-atopic-eczema-trial-treat
#15
A D Irvine, A P Jones, P Beattie, S Baron, F Browne, F Ashoor, L O'Neill, A Rosala-Hallas, T Sach, C Spowart, L Taams, C Walker, M Wan, N Webb, P Williamson, C Flohr
BACKGROUND: Oral systemic immuno-modulatory medication is regularly used off-licence in children with severe atopic eczema. However, there is no firm evidence regarding the effectiveness, safety, cost-effectiveness and impact on quality of life from an adequately powered randomised controlled trial (RCT) using systemic medication in children. PATIENTS/METHODS: Multi-centre, parallel group, assessor-blind, pragmatic RCT of 36 week duration with a 24 week follow-up period...
May 4, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29724749/emollient-bath-additives-for-the-treatment-of-childhood-eczema-bathe-multicentre-pragmatic-parallel-group-randomised-controlled-trial-of-clinical-and-cost-effectiveness
#16
Miriam Santer, Matthew J Ridd, Nick A Francis, Beth Stuart, Kate Rumsby, Maria Chorozoglou, Taeko Becque, Amanda Roberts, Lyn Liddiard, Claire Nollett, Julie Hooper, Martina Prude, Wendy Wood, Kim S Thomas, Emma Thomas-Jones, Hywel C Williams, Paul Little
OBJECTIVES: To determine the clinical effectiveness and cost effectiveness of including emollient bath additives in the management of eczema in children. DESIGN: Pragmatic randomised open label superiority trial with two parallel groups. SETTING: 96 general practices in Wales and western and southern England. PARTICIPANTS: 483 children aged 1 to 11 years, fulfilling UK diagnostic criteria for atopic dermatitis. Children with very mild eczema and children who bathed less than once weekly were excluded...
May 3, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29722071/texting-atopic-dermatitis-patients-to-optimize-learning-and-eczema-area-and-severity-index-scores-a-pilot-randomized-control-trial
#17
Hannah M Singer, Laura E Levin, Kimberly D Morel, Maria C Garzon, Melissa S Stockwell, Christine T Lauren
BACKGROUND/OBJECTIVES: Atopic dermatitis is a common, chronic, debilitating disease. Poor adherence to treatment is the most important preventable contributor to adverse outcomes. Thus, improving adherence can improve patient outcomes. Text message reminders with embedded condition-specific information have been shown to improve pediatric immunization adherence but have not been assessed in atopic dermatitis. The objective was to assess the effect of daily text messages on Eczema Area Severity Index scores and caregiver knowledge of atopic dermatitis...
May 2, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29706022/terra-firma-forme-dermatosis-is-underestimated-in-children-and-is-associated-with-atopic-dermatitis
#18
I Neri, F Savoia, V Tengattini, A Sechi, P Rucci, A Patrizi
Terra firma-forme dermatosis (TFFD) is an acquired benign disorder that is characterized by brown-gray patches or plaques, presenting as dirt-like pigmented areas (1, 2). The diagnosis is usually confirmed by the clearing with isopropyl or 70% ethyl alcohol swab, that is also the gold standard of treatment. Dermoscopy of TFFD may show large polygonal plate-like brown scales arranged together giving a mosaic or cobblestone pattern (3) This article is protected by copyright. All rights reserved.
April 28, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29691836/early-life-regional-and-temporal-variation-in-filaggrin-derived-natural-moisturising-factor-filaggrin-processing-enzyme-activity-corneocyte-phenotypes-and-plasmin-activity-implications-for-atopic-dermatitis
#19
M A McAleer, I Jakasa, N Raj, C P F O'Donnell, M E Lane, A V Rawlings, R Voegeli, W H I McLean, S Kezic, A D Irvine
BACKGROUND: Filaggrin is central to the pathogenesis of atopic dermatitis (AD). The cheeks are a common initiation site of infantile AD. Regional and temporal expression of levels of filaggrin degradation products (natural moisturising factors, NMF), activities of filaggrin processing enzymes (bleomycin hydrolase; BH and calpain-1; C-1) and plasmin, and corneocyte envelope (CE) maturity in early life are largely unknown. OBJECTIVES: We did a cross-sectional, observational study investigating regional and age dependent variations in NMF levels, activity of proteases and CE maturity in stratum corneum (SC) from infants to determine if these could explain the observed predilection sites for AD in early life...
April 25, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29680987/slit-s-prevention-of-the-allergic-march
#20
REVIEW
Federica Porcaro, Giovanni Corsello, Giovanni Battista Pajno
PURPOSE OF REVIEW: The progression of atopic disorders from atopic dermatitis in infants to allergic rhinitis and asthma in children, adolescents, and adults defines the allergy march. Allergen immunotherapy is the only causal treatment altering the immunological mechanism underlying the allergic diseases. The sublingual administration route is more acceptable than the subcutaneous one in pediatric age. RECENT FINDINGS: Several studies show the efficacy and safety profile of sublingual immunotherapy (SLIT) for the treatment of respiratory allergy diseases, but few data are available on its effect of primary and secondary prevention of allergic disease...
April 21, 2018: Current Allergy and Asthma Reports
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