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atopic dermatitis in children

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https://www.readbyqxmd.com/read/27931973/effect-of-probiotics-in-prevention-of-atopic-dermatitis-is-dependent-on-the-intrinsic-microbiota-at-early-infancy
#1
Ekaterina Avershina, Raul Cabrera-Rubio, Krister Lundgård, Gaspar Perez-Martinez, Maria Carmen Collado, Ola Storrø, Torbjørn Øien, Christian Kvikne Dotterud, Roar Johnsen, Knut Rudi
Although a link between probiotic intervention and reduction in atopic disease has been documented, no consistent associations with microbiota has yet been established. Here we have conducted an extensive analysis of the microbiota from more than 250 mother child pairs from a probiotic intervention cohort, where we previously have shown 40 % reduction in atopic dermatitis. Within the probiotic intervention group at the age of 10 days we found that the atopic children had a deviating microbiota (p = 0.028, BH-FDR corrected Kruskal Wallis) with high levels (> 10 %) of a bacterium related to Bifidobacterium dentium (p=0...
December 5, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27920408/asthma-and-other-allergic-diseases-among-saudi-schoolchildren-in-najran-the-need-for-a-comprehensive-intervention-program
#2
Jobran M Alqahtani
BACKGROUND: In the last three decades, an increasing incidence of allergic diseases has been associated with increasing morbidity and mortality in children and young adults. OBJECTIVES: The study aimed to investigate the prevalence and risk factors associated with allergic diseases among Saudi schoolchildren in the southwestern Saudi region of Najran, and to determine the sensitization of patients to a set of allergens. DESIGN: Cross-sectional observational study...
November 2016: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/27918476/antenatal-dexamethasone-exposure-in-preterm-infants-is-associated-with-allergic-diseases-and-the-mental-development-index-in-children
#3
Wan-Ning Tseng, Chih-Cheng Chen, Hong-Ren Yu, Li-Tung Huang, Ho-Chang Kuo
Background: Antenatal steroid administration may benefit fetal lung maturity in preterm infants. Although some studies have shown that this treatment may increase asthma in childhood, the correlation between antenatal dexamethasone exposure and allergic diseases remains unclear. The purpose of this study is to investigate the association between antenatal dexamethasone and T cell expression in childhood allergic diseases. Methods: We recruited a cohort of preterm infants born at Kaohsiung Chang Gung Memorial Hospital between 2007 and 2010 with a gestational age of less than 35 weeks and body weight at birth of less than 1500 g...
December 3, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27914645/comparison-of-diverse-estimation-methods-for-personal-exposure-to-air-pollutants-and-associations-with-allergic-symptoms-the-allergy-gene-environment-link-angel-study
#4
Young-Min Kim, Jihyun Kim, Youngshin Han, Byung-Jae Lee, Dong-Chull Choi, Hae-Kwan Cheong, Byoung-Hak Jeon, Inbo Oh, Gwi-Nam Bae, Jae Young Lee, Chang-Heok Kim, SungChul Seo, Su Ryeon Noh, Kangmo Ahn
We estimated the exposure to ambient air pollutants and analyzed the associations with allergic diseases. We enrolled 177 children with atopic dermatitis (AD) and 70 asthmatic adults living in Seoul Metropolitan Area, Korea, and followed for 17months between August 2013 and December 2014. Parents or patients recorded symptom scores on a daily basis. Exposure to particulate matter with a diameter <10μm (PM10) and nitrogen dioxide (NO2) was estimated in four different ways in each individual, using the AQ1 (measurements from the nearest air quality monitoring station to residential houses), AQ2 (measurements modified from AQ1 with the indoor level of air pollutants and time activity of each individual), AQ1-DI, and AQ2-DI (measurements modified from AQ1 and AQ2, respectively, with daily inhalation intakes of air pollutants)...
November 30, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27908570/sleep-related-disorders-in-latin-american-children-with-atopic-dermatitis-a-case-control-study
#5
M Urrutia-Pereira, D Solé, N A Rosario, H J C Neto, V Acosta, C F Almendarez, M M Avalos, H Badellino, F Berroa, M Álvarez-Castelló, A J Castillo, R L Castro-Almarales, M M De la Cruz, A M Cepeda, C Fernandez, M González-León, J Lozano-Saenz, C Sanchez-Silot, J C Sisul-Alvariza, M Valentin-Rostan, R O S Sarni
BACKGROUND: Atopic dermatitis (AD) has been associated with impairment of sleep. The aim of this study was to evaluate sleep disorders in AD Latin-American children (4-10 years) from nine countries, and in normal controls (C). METHODS: Parents from 454 C and 340 AD children from referral clinics answered the Children Sleep Habits Questionnaire (CSHQ), a one-week retrospective 33 questions survey under seven items (bedtime resistance, sleep duration, sleep anxiety, night awakening, parasomnias, sleep-disordered breathing and daytime sleepiness)...
November 28, 2016: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/27904272/awareness-of-atopic-dermatitis-and-attitudes-toward-different-types-of-medical-institutions-for-its-treatment-among-adult-patients-and-the-parents-of-pediatric-patients-a-survey-of-500-participants
#6
Nam Kyung Roh, Song Hee Han, Min Jung Kim, Gyeong-Hun Park, Bark-Lynn Lew, Eung Ho Choi, Hyun Chang Ko, Young Lip Park, Sang Wook Son, Young Jun Seo, Yang Won Lee, Sang Hyun Cho, Chun Wook Park
BACKGROUND: Physicians can play a crucial role in the knowledge that patients have about a disease and its prognosis. Recently, patients with atopic dermatitis (AD) are increasingly turning from western medicine to oriental herbal medicine. However, their awareness of AD and attitude toward Western medicine and oriental herbal medicine clinics are scarcely reported. OBJECTIVE: The aim of this study was to determine the understanding of AD among patients and their parents and to identify their awareness of and attitude toward Western medicine and oriental herbal medicine as treatments for AD...
December 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27904266/four-years-prospective-study-of-natural-history-of-atopic-dermatitis-aged-7-8-years-at-an-individual-level-a-community-based-survey-by-dermatologists-skin-examination-in-childhood
#7
Young Jee Kim, Sook Jung Yun, Jee-Bum Lee, Seong Jin Kim, Young Ho Won, Seung-Chul Lee
BACKGROUND: The age-dependent change in atopic dermatitis (AD) at an individual level has mostly performed in a hospital-setting. OBJECTIVE: We evaluated the age-dependent change of AD symptoms at an individual level in a community-setting. METHODS: For the diagnostic accuracy, all participants of schoolchildren were received skin examination by dermatologists (twice a year for the same group), instead of questionnaire-based surveys. For this study, sequential check-ups of 273 elementary school children, aged 7~8 years, were performed for 4 years up to the age of 10~11 years...
December 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27904185/topical-therapy-in-atopic-dermatitis-in-children
#8
Dharshini Sathishkumar, Celia Moss
Atopic dermatitis (AD) is a common, chronic childhood skin disorder caused by complex genetic, immunological, and environmental interactions. It significantly impairs quality of life for both child and family. Treatment is complex and must be tailored to the individual taking into account personal, social, and emotional factors, as well as disease severity. This review covers the management of AD in children with topical treatments, focusing on: education and empowerment of patients and caregivers, avoidance of trigger factors, repair and maintenance of the skin barrier by correct use of emollients, control of inflammation with topical corticosteroids and calcineurin inhibitors, minimizing infection, and the use of bandages and body suits...
November 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27902816/association-of-filaggrin-loss-of-function-and-thymic-stromal-lymphopoietin-variation-with-treatment-use-in-pediatric-atopic-dermatitis
#9
Joshua Chang, Nandita Mitra, Ole Hoffstad, David J Margolis
Importance: Atopic dermatitis (AD) is a common illness of childhood. Objective: To determine whether variations in FLG and TSLP genotype corresponded to differences in treatment use over time. Design, Setting, and Participants: This prospective cohort study recruited and followed a volunteer sample of 842 children enrolled in the Pediatric Eczema Elective Registry who provided saliva samples for DNA extraction for 10 years. Eligibility criteria included age 2 to 17 years, AD diagnosis without cancer, and prior pimecrolimus use...
November 30, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27896861/cyclosporine-a-for-severe-atopic-dermatitis-in-children-efficacy-and-safety-in-a-retrospective-study-of-63-patients
#10
A Hernández-Martín, L Noguera-Morel, B Bernardino-Cuesta, A Torrelo, M A Pérez-Martin, C Aparicio-López, C de Lucas-Collantes
BACKGROUND: Cyclosporin A (CSA) is an immunosuppressant agent widely used in severe atopic dermatitis (AD). However, experience in children is limited. OBJECTIVES: To assess the efficacy and adverse events of CSA therapy in children. METHODS: Retrospective study of children with severe AD treated with CSA between January 2009 and December 2015. RESULTS: Data from 63 patients were collected. Mean age at the beginning of treatment was 8...
November 29, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27865579/impact-of-childhood-psoriasis-on-parents-of-affected-children
#11
Megha M Tollefson, Dawn M Finnie, Jennifer J Schoch, David T Eton
BACKGROUND: Childhood diseases, such as atopic dermatitis, have a negative impact on quality of life (QoL) of parents. How pediatric psoriasis affects a parent's QoL is unknown. OBJECTIVE: To explore the impact of childhood psoriasis on the lives of the parents. METHODS: Semistructured interviews were conducted with 31 parents of children with psoriasis. Narrative data were analyzed and a conceptual framework of the effects of childhood psoriasis on parents was developed...
November 16, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27861990/contact-sensitization-in-dutch-children-and-adolescents-with-and-without-atopic-dermatitis%C3%A2-%C3%A2-a-retrospective-analysis
#12
Stefanie Lubbes, Thomas Rustemeyer, Johannes H Sillevis Smitt, Marie-Louise A Schuttelaar, Maritza A Middelkamp-Hup
BACKGROUND: Allergic contact dermatitis is known to occur in children with and without atopic dermatitis, but more data are needed on contact sensitization profiles in these two groups. OBJECTIVES: To identify frequent allergens in children with and without atopic dermatitis suspected of having allergic contact dermatitis. METHODS: A retrospective analysis of children aged 0-17 years patch tested between 1996 and 2013 was performed. RESULTS: Of all 1012 children tested because of suspected contact dermatitis, 46% developed one or more positive reactions, the proportions for children with (n = 526) and without (n = 395) atopic dermatitis being 48% and 47%, respectively...
November 11, 2016: Contact Dermatitis
https://www.readbyqxmd.com/read/27861978/circulating-cla-t-cells-in-atopic-dermatitis-and-their-possible-role-as-peripheral-biomarkers
#13
REVIEW
Tali Czarnowicki, Luis F Santamaria-Babí, Emma Guttman-Yassky
Cutaneous lymphocyte-associated antigen (CLA(+) ) T-cells are specialized for skin homing and represent the main T-cell population in atopic dermatitis (AD) lesions. CLA(+) is expressed on the surface of circulating CD45RO(+) memory T-cells and most skin infiltrating T-cells. Mechanistic studies and thus treatment advancements are limited by the need of large number of skin biopsies. Circulating CLA(+) T-cells may be a reliable surrogate marker of the inflammatory events occurring in the skin, and thus the evaluation of CLA(+) T-cells in the blood may eliminate the need for skin biopsies...
November 8, 2016: Allergy
https://www.readbyqxmd.com/read/27861727/efficacy-and-safety-of-wet-wrap-therapy-for-patients-with-atopic-dermatitis-a-systematic-review-and-meta-analysis
#14
REVIEW
G González-López, R M Ceballos-Rodríguez, J J González-López, M Feito Rodríguez, P Herranz-Pinto
BACKGROUND: Wet wrap therapy (WWT) consists of topical steroids administered under a layer of wet cotton bandages or garments. Several trials with WWT have reported promising results in atopic dermatitis (AD). However, no systematic review and meta-analysis on its efficacy and safety has been published. OBJECTIVES: To systematically review the literature on WWT in AD to assess its efficacy and safety. METHODS: We included randomized controlled trials among patients of all ages with a diagnosis of AD based on predefined criteria or performed by a dermatologist...
November 8, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27855965/prescribing-practices-for-systemic-agents-in-the-treatment-of-severe-pediatric-atopic-dermatitis-in-the-us-and-canada-the-pedra-treat-survey
#15
Christine R Totri, Lawrence F Eichenfield, Kirsty Logan, Laura Proudfoot, Jochen Schmitt, Irene Lara-Corrales, Jeffrey Sugarman, Wynnis Tom, Elaine Siegfried, Kelly Cordoro, Amy S Paller, Carsten Flohr
BACKGROUND: There is a paucity of literature to direct physicians in the prescribing of immunomodulators for patients with severe atopic dermatitis (AD). OBJECTIVE: To survey systemic agent prescribing practices for severe childhood AD among clinicians in the United States and Canada. METHODS: The TREatment of severe Atopic dermatitis in children Taskforce (TREAT), US&CANADA, a project of the Pediatric Dermatology Research Alliance (PeDRA), developed an online multiple-response survey to assess clinical practice, gather demographic information and details of systemic agent selection, and identify barriers to their use in patients with recalcitrant pediatric AD...
November 14, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27846627/targeting-the-t-helper-2-inflammatory-axis-in-atopic-dermatitis
#16
Adriana S Moreno, Roderick McPhee, Luisa Karla Arruda, Michael D Howell
Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects up to 25% of children and 10% of adults. The skin of patients with moderate to severe AD is characterized by significant barrier disruption and T helper 2 (Th2)-driven inflammation, which are thought to play a significant role in the pathogenesis of AD. Current management of AD is aimed at suppressing the inflammatory response and restoring the barrier function of the skin, reducing exacerbations, and preventing secondary skin infections...
November 16, 2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/27843531/erratum-to-debates-in-allergy-medicine-specific-immunotherapy-efficiency-in-children-with-atopic-dermatitis
#17
Tatiana A Slavyanskaya, Vladislava V Derkach, Revaz I Sepiashvili
[This corrects the article DOI: 10.1186/s40413-016-0106-3.].
2016: World Allergy Organization Journal
https://www.readbyqxmd.com/read/27832218/guidelines-for-the-management-of-atopic-dermatitis-in-singapore
#18
Yong Kwang Tay, Yuin Chew Chan, Nisha Suyien Chandran, Madeline Sl Ho, Mark Ja Koh, Yen Loo Lim, Mark By Tang, Thamotharampillai Thirumoorthy
INTRODUCTION: Atopic dermatitis is a common, chronic pruritic condition affecting both children and adults, which has a negative impact on the quality of life. These guidelines were developed by an expert workgroup appointed by the Dermatological Society of Singapore, to provide doctors with information to assist in the management of their patients with atopic dermatitis. The workgroup members are experienced dermatologists with interest and expertise in eczemas. MATERIALS AND METHODS: Workgroup members arrived at a consensus on the topics to be included...
October 2016: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/27828633/staphylococcus-aureus-resistance-to-topical-antimicrobials-in-atopic-dermatitis
#19
Giancarlo Rezende Bessa, Vanessa Petry Quinto, Daiane Corrêa Machado, Caroline Lipnharski, Magda Blessmann Weber, Renan Rangel Bonamigo, Pedro Alves D'Azevedo
Background: Topical antimicrobial drugs are indicated for limited superficial pyodermitis treatment, although they are largely used as self-prescribed medication for a variety of inflammatory dermatoses, including atopic dermatitis. Monitoring bacterial susceptibility to these drugs is difficult, given the paucity of laboratory standardization. Objective: To evaluate the prevalence of Staphylococcus aureus topical antimicrobial drug resistance in atopic dermatitis patients...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27803881/family-quality-of-life-among-families-of-children-with-atopic-dermatitis
#20
Hae Ji Jang, Seonyeong Hwang, Youngmee Ahn, Dae Hyun Lim, Min Sohn, Jeong Hee Kim
BACKGROUND: Atopic dermatitis (AD) may cause emotional distress and impairs the quality of life (QoL) in children and their families. OBJECTIVE: We examined family QoL of children with AD and explored associated factors such as disease severity and psychosocial factors among parents of children with AD. METHODS: Study participants were 78 children (1 month to 16 years old) diagnosed with AD and their parents visiting an outpatient clinic of the Department of Pediatrics in Inha University Hospital...
October 2016: Asia Pacific Allergy
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