Jie Fu, Xin Zong, Mingliang Jin, Junxia Min, Fudi Wang, Yizhen Wang
As a family of cationic host defense peptides, defensins are mainly synthesized by Paneth cells, neutrophils, and epithelial cells, contributing to host defense. Their biological functions in innate immunity, as well as their structure and activity relationships, along with their mechanisms of action and therapeutic potential, have been of great interest in recent years. To highlight the key research into the role of defensins in human and animal health, we first describe their research history, structural features, evolution, and antimicrobial mechanisms...
August 14, 2023: Signal Transduction and Targeted Therapy