keyword
https://read.qxmd.com/read/38496155/profile-of-acute-kidney-injury-in-the-pediatric-age-group-in-a-tertiary-care-hospital-a-prospective-observational-study
#21
JOURNAL ARTICLE
Ishan Kapil, Anil Kumar Goel, Manas R Sahoo
BACKGROUND AND OBJECTIVES: Acute kidney injury (AKI) is a menace in the pediatric intensive care unit (PICU) and is responsible for significant morbidity and mortality all over the world. There are limited data available on pediatric AKI in central India. Our primary objective is to determine the clinical, etiological, and outcome profile of AKI in the pediatric age group of 3 months to 15 years admitted to the All India Institute of Medical Sciences (AIIMS), Raipur. The secondary objective(s) is to predict the association of mortality in children diagnosed with AKI and to estimate the number of patients developing chronic kidney disease (CKD) at three-month follow-up...
February 2024: Curēus
https://read.qxmd.com/read/38492030/clinical-course-and-peculiarities-of-parechovirus-and-enterovirus-central-nervous-system-infections-in-newborns-a-single-center-experience
#22
JOURNAL ARTICLE
Giacomo Brisca, Tommaso Bellini, Mattia Pasquinucci, Marcello Mariani, Marta Romanengo, Isabella Buffoni, Domenico Tortora, Alessandro Parodi, Elena Fueri, Alessio Mesini, Jessica Tibaldi, Emanuela Piccotti, Luca Antonio Ramenghi, Andrea Moscatelli
Parechovirus (HpEV) and Enterovirus (EV) infections in children mostly have a mild course but are particularly fearsome in newborns in whom they may cause aseptic meningitis, encephalitis, and myocarditis. Our study aimed to describe the clinical presentations and peculiarities of CNS infection by HpEV and EV in neonates. This is a single-center retrospective study at Istituto Gaslini, Genoa, Italy. Infants aged ≤ 30 days with a CSF RTq-PCR positive for EV or HpEV from January 1, 2022, to December 1, 2023, were enrolled...
March 16, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38491449/the-footprint-of-sars-cov-2-infection-in-neonatal-late-sepsis
#23
JOURNAL ARTICLE
Zahra Jamali, Najmeh Mohammadpour, Reza Sinaei, Maedeh Jafari, Fatemeh Sabzevari, Mohammad Hasannejad
BACKGROUND: Predicting and finding the viral agents responsible for neonatal late-sepsis has always been challenging. METHOD: In this cross-sectional study, which has been done from September 2020 to December 2022, 145 hospitalized neonates suspected to late-onset sepsis alongside routine sepsis workup, were also evaluated for severe acute respiratory syndrome-coronavirus-2 (SARS-COV-2) infection, by nasopharyngeal real-time polymerase chain reaction (RT-PCR) or serological tests...
March 16, 2024: BMC Pediatrics
https://read.qxmd.com/read/38491391/risk-factors-for-venous-thromboembolism-in-a-single-pediatric-intensive-care-unit-in-china
#24
JOURNAL ARTICLE
Jintuo Zhou, Yanting Zhu, Ying Liu, Hairong Zhan, Peiguang Niu, Huajiao Chen, Jinhua Zhang
BACKGROUND: Analyses of extensive, nationally representative databases indicate a rising prevalence of venous thromboembolism (VTE) among critically ill children. However, the majority of studies on childhood VTE have primarily concentrated on Caucasian populations in the United States and European countries. There is a lack of epidemiological studies on VTE in Chinese children. METHODS: We conducted a retrospective cohort study of data from the Pediatric Intensive Care (PIC) database...
March 15, 2024: Thrombosis Journal
https://read.qxmd.com/read/38489000/diagnostic-accuracy-of-endotoxin-and-endotoxin-binding-protein-in-late-onset-neonatal-sepsis
#25
JOURNAL ARTICLE
Divya Katta, Kopula Satyamoorthy Sridharan, UmaMaheswari Balakrishnan, Prakash Amboiram, Gopi Dhivya, Kennedy Kumar Palraj
OBJECTIVES: To evaluate the diagnostic utility of endotoxin and endotoxin binding protein (EBP) for the diagnosis of late-onset neonatal sepsis (LOS) and compare it with the diagnostic utility of C-reactive protein (CRP). METHODS: This diagnostic study of neonates, both term and preterm, with clinical suspicion of LOS was conducted in a tertiary care institute in India between January 2021 and March 2023. Blood samples were collected for evaluating endotoxin and EBP along with culture...
March 15, 2024: Indian Journal of Pediatrics
https://read.qxmd.com/read/38476806/novel-two-infusion-pump-technique-for-exchange-transfusion-in-a-hyperbilirubinemic-neonate
#26
Naramreddy Sudheesh Reddy, Aditi Rawat, Sagar Karotkar, Ashish Varma, Amar Taksande, Revat J Meshram, Chaitanya Kumar Javvaji, SreeHarsha Damam
Neonatal hyperbilirubinemia is a common concern in newborns, with ABO blood group incompatibility serving as a significant risk factor for severe jaundice. This case report outlines the successful management of a 2.5 kg female infant born to a primigravida mother with ABO incompatibility-induced hyperbilirubinemia. The neonate, born at 38.4 weeks via lower segment cesarean section, exhibited signs of jaundice at 91 hours of life, prompting screening and subsequent confirmation of serum bilirubin levels 26...
February 2024: Curēus
https://read.qxmd.com/read/38476465/assessing-long-term-vestibulotoxic-side-effects-after-gentamicin-therapy-in-neonatal-sepsis-or-infection-using-video-head-impulse-test
#27
JOURNAL ARTICLE
Lena Zaubitzer, Anja Kotzur, Stefan Hegemann, Nicole Rotter, Angela Schell
STUDY BACKGROUND: Newborn infection and sepsis remain serious problems. Guideline-compliant therapy includes, among other therapeutics, calculated intravenous antibiosis with gentamicin. One of the known side effects of gentamicin is severe vestibulotoxicity, which can be detected using the video head impulse test (VHIT), which is a sensitive examination method for the detection of vestibular hypofunction in children and adults. Previous studies on the vestibulotoxicity of gentamicin in newborns were carried out using caloric testing, rotary testing, and electronystagmography...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38471759/emergency-department-sepsis-triage-scoring-tool-elements-associated-with-hypotension-within-24-hours-in-children-with-fever-and-tachycardia
#28
JOURNAL ARTICLE
Alexandra H Baker, Vanessa M Mazandi, Jackson S Norton, Elliot Melendez
OBJECTIVE: Pediatric sepsis screening is becoming the standard of care for children presenting to the emergency department (ED) and has been shown to improve recognition of severe sepsis, but it is unknown if these screening tools can predict progression of disease. The objective of this study was to determine if any elements of a sepsis triage trigger tool were predictive of progression to hypotensive shock in children presenting to the ED with fever and tachycardia. METHODS: This study is a retrospective case-control study of children ≤18 years presenting to an ED with fever and tachycardia, comparing those who went on to develop hypotensive shock in the subsequent 24 hours (case) to those who did not (control)...
March 13, 2024: Pediatric Emergency Care
https://read.qxmd.com/read/38471259/data-quality-review-of-the-brazilian-nosocomial-infections-surveillance-system
#29
JOURNAL ARTICLE
Alice Ramos Silva, Nicolas Guedes Hoffmann, Fernando Fernandez-Llimos, Elisangela Costa Lima
BACKGROUND: Surveillance of healthcare-associated infections (HAIs) is an essential component of hospital infection prevention and control systems. We aimed to assess the quality of the data compiled by the Brazilian HAI Surveillance System from pediatric (PICUs) and neonatal intensive care units (NICUs), between 2012 and 2021. METHODS: Data Quality Review, including adherence, completeness, internal consistency, consistency over time, and consistency of population trend, were computed at both national and state levels based on quality metrics from World Health Organization Toolkit...
February 27, 2024: Journal of Infection and Public Health
https://read.qxmd.com/read/38470629/impact-of-rapid-response-teams-on-pediatric-care-an-interrupted-time-series-analysis-of-unplanned-picu-admissions-and-cardiac-arrests
#30
JOURNAL ARTICLE
Samah Al-Harbi
Pediatric rapid response teams (RRTs) are expected to significantly lower pediatric mortality in healthcare settings. This study evaluates RRTs' effectiveness in decreasing cardiac arrests and unexpected Pediatric Intensive Care Unit (PICU) admissions. A quasi-experimental study (2014-2017) at King Abdulaziz University Hospital, Jeddah, Saudi Arabia, involved 3261 pediatric inpatients, split into pre-intervention (1604) and post-intervention (1657) groups. Baseline pediatric warning scores and monthly data on admissions, transfers, arrests, and mortality were analyzed pre- and post-intervention...
February 21, 2024: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/38469841/time-to-attain-full-enteral-feeds-among-preterm-fetal-growth-restricted-neonates-with-absent-reversed-end-diastolic-flow
#31
JOURNAL ARTICLE
Veena Anand, S Geetha, Priya Sreenivasan, Sobha Kumar, K Rajamohanan
OBJECTIVES: To determine the difference in time to attainment of full enteral feeds between fetal growth restricted (FGR) preterm neonates with and without absent/reversed end-diastolic flow (AREDF). Secondary objectives were to compare the short-term outcomes including the incidence of necrotizing enterocolitis (NEC) and feed intolerance between the two groups and to determine the factors affecting the time to attainment of full enteral feeds (FEF) among preterm FGR neonates. METHODS: A prospective cohort study was conducted among consecutive preterm FGR neonates delivered at 28-36 weeks gestation admitted in level III NICU...
March 15, 2024: Indian Pediatrics
https://read.qxmd.com/read/38469402/retrospective-analysis-of-pediatric-sepsis-and-the-burden-of-antimicrobial-resistance-in-duhok-kurdistan-region-of-iraq
#32
JOURNAL ARTICLE
Delveen R Ibrahim, Abdulrhaman T Saadi, Nizar B Yahya, Marwa S Ibrahim, Ali Y Saeed, Sawsan S Abdulaziz, Revan Y Hasqyal, Berivan K Alarsalani, Khalid S Ibrahim
Introduction: Sepsis is a life-threatening complication in pediatric patients. This study primarily aimed to investigate sepsis-causing bacteria and their antimicrobial resistance profile and check the change in the antimicrobial resistance trend for some selected bacteria. In addition, we evaluated the incidence of sepsis, the related mortality rate, and the effectiveness and outcome of the treatment regimes in sepsis pediatric patients. Methods: A retrospective analysis was conducted on 4-year data (2018-2021) collected from three intensive care units at the Hevi Pediatric Teaching Hospital...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38465952/biomarker-assessment-of-a-high-risk-data-driven-pediatric-sepsis-phenotype-characterized-by-persistent-hypoxemia-encephalopathy-and-shock
#33
JOURNAL ARTICLE
Mihir R Atreya, Tellen D Bennett, Alon Geva, E Vincent S Faustino, Colin M Rogerson, Riad Lutfi, Natalie Z Cvijanovich, Michael T Bigham, Jeffrey Nowak, Adam J Schwarz, Torrey Baines, Bereketeab Haileselassie, Neal J Thomas, Yuan Luo, L Nelson Sanchez-Pinto
OBJECTIVES: Identification of children with sepsis-associated multiple organ dysfunction syndrome (MODS) at risk for poor outcomes remains a challenge. We sought to the determine reproducibility of the data-driven "persistent hypoxemia, encephalopathy, and shock" (PHES) phenotype and determine its association with inflammatory and endothelial biomarkers, as well as biomarker-based pediatric risk strata. DESIGN: We retrained and validated a random forest classifier using organ dysfunction subscores in the 2012-2018 electronic health record (EHR) dataset used to derive the PHES phenotype...
March 11, 2024: Pediatric Critical Care Medicine
https://read.qxmd.com/read/38460893/the-landscape-of-immune-dysregulation-in-pediatric-sepsis-at-a-single-cell-resolution
#34
JOURNAL ARTICLE
Fahd Alhamdan, Sophia Koutsogiannaki, Koichi Yuki
Recognizing immune dysregulation as a hallmark of sepsis pathophysiology, leukocytes have attracted major attention of investigation. While adult and pediatric sepsis are clinically distinct, their immunological delineation remains limited. Single cell technologies facilitated the characterization of immune signatures. We tackled to delineate immunological profiles of pediatric sepsis at a single-cell level by analyzing blood samples from six septic children, at both acute and recovery phases, and four healthy children...
March 7, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38459470/mortality-and-associated-factors-among-children-admitted-to-an-intensive-care-unit-in-muhimbili-national-hospital-from-the-time-of-admission-to-three-months-after-discharge-a-prospective-cohort-study
#35
JOURNAL ARTICLE
Rehema E Lyimo, Yasser H Said, Sokoine L Kivuyo, Deogratias Nkya, Francis F Furia
BACKGROUND: Mortality of children admitted to Intensive Care Units (ICU) is higher in low-to-middle-income countries (LMICs) as compared to high-income countries (HICs). There is paucity of information on outcomes following discharge from ICU, especially from sub-Saharan Africa region. This study was conducted to determine mortality and its associated factors among children admitted to Pediatric ICU (PICU) at Muhimbili National Hospital, from admission to three months after discharge...
March 8, 2024: BMC Pediatrics
https://read.qxmd.com/read/38459440/the-role-of-nutrition-in-analysis-of-risk-factors-and-short-term-outcomes-for-late-onset-necrotizing-enterocolitis-among-very-preterm-infants-%C3%A2-a-nationwide-multicenter-study-in-china
#36
MULTICENTER STUDY
Kun-Yao Hong, Yao Zhu, Fan Wu, Jian Mao, Ling Liu, Rong Zhang, Yan-Mei Chang, Wei Shen, Li-Xia Tang, Xiu-Zhen Ye, Yin-Ping Qiu, Li Ma, Rui Cheng, Hui Wu, Dong-Mei Chen, Ling Chen, Ping Xu, Hua Mei, San-Nan Wang, Fa-Lin Xu, Rong Ju, Zhi Zheng, Xiao-Mei Tong, Xin-Zhu Lin
BACKGROUND: Necrotizing enterocolitis (NEC) is a serious gastrointestinal disease, primarily affects preterm newborns and occurs after 7 days of life (late-onset NEC, LO-NEC). Unfortunately, over the past several decades, not much progress has been made in its treatment or prevention. This study aimed to analyze the risk factors for LO-NEC, and the impact of LO-NEC on short-term outcomes in very preterm infants (VPIs) with a focus on nutrition and different onset times. METHOD: Clinical data of VPIs were retrospectively collected from 28 hospitals in seven different regions of China from September 2019 to December 2020...
March 8, 2024: BMC Pediatrics
https://read.qxmd.com/read/38456989/risk-factors-for-infant-hearing-loss-a-meta-analysis
#37
JOURNAL ARTICLE
Yiwei Han, Shangbin Li, Yankun Song, Jingfei Sun, Weichen Yan, Jie Wang, Xiong Gao, Xueying Li, Changjun Ren, Qian Zhao
Hearing loss is a common disability in infants that significantly impacts their cognitive, language, and literacy development. This study aimed to systematically assess the risk factors for the early identification and intervention in infant hearing loss. Databases were searched for meta-analyses of observational studies until November 2023. The quality assessment was performed using the Cochrane risk of bias tool, and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach was used to assess the certainty of the evidence...
March 8, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38454423/pediatric-sepsis-inflammatory-blood-biomarkers-that-correlate-with-clinical-variables-and-severity-of-illness-scores
#38
JOURNAL ARTICLE
Sean Leonard, Hailey Guertin, Natalya Odoardi, Michael R Miller, Maitray A Patel, Mark Daley, Gediminas Cepinskas, Douglas D Fraser
BACKGROUND: Sepsis is a dysregulated systemic inflammatory response triggered by infection, resulting in organ dysfunction. A major challenge in clinical pediatrics is to identify sepsis early and then quickly intervene to reduce morbidity and mortality. As blood biomarkers hold promise as early sepsis diagnostic tools, we aimed to measure a large number of blood inflammatory biomarkers from pediatric sepsis patients to determine their predictive ability, as well as their correlations with clinical variables and illness severity scores...
March 7, 2024: Journal of Inflammation
https://read.qxmd.com/read/38452183/outcomes-for-pediatric-oncology-and-hematopoietic-stem-cell-transplantation-patients-who-undergo-tracheostomy-placement-a-pediatric-health-information-system-database-cohort-study-2009-2020
#39
JOURNAL ARTICLE
Sinead L Murphy Salem, Jennifer M Perez, Steven J Staffa, Christine N Duncan, Robert J Graham
OBJECTIVES: To describe the epidemiology, surgical complications, and long-term outcomes after tracheostomy in pediatric oncology and/or hematopoietic stem cell transplantation (HSCT) patients in U.S. Children's Hospitals. DESIGN: Retrospective cohort from the Pediatric Health information System (PHIS) database, 2009-2020. SETTING: The PHIS dataset incorporates data from 48 pediatric hospitals in the Children's Hospital Association. PATIENTS: Patients 0-21 years old with an oncologic diagnosis and/or underwent HSCT, received a tracheostomy, and were discharged from hospital between January 1, 2009, and December 31, 2020...
March 7, 2024: Pediatric Critical Care Medicine
https://read.qxmd.com/read/38451061/catheter-salvage-from-central-line-related-bloodstream-infections-in-pediatric-intestinal-failure
#40
JOURNAL ARTICLE
Catherine Larson-Nath, Linder Wendt, Riad Rahhal
OBJECTIVES: Patients with intestinal failure require central venous access which puts them at risk for central line-associated bloodstream infections (CLABSI). Maintaining vascular patency is critical for this population to receive nutrition support. When CLABSIs occur line salvage can help maintain vascular access. The aim of this study is to assess factors associated with safe and successful central venous catheter salvage. METHODS: Retrospective cohort study of patients with intestinal failure at two tertiary care institutions between 2012 and 2020...
March 7, 2024: Journal of Pediatric Gastroenterology and Nutrition
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