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https://www.readbyqxmd.com/read/29773998/larger-gray-matter-volume-in-the-basal-ganglia-of-heavy-cannabis-users-detected-by-voxel-based-morphometry-and-subcortical-volumetric-analysis
#1
Ana Moreno-Alcázar, Begoña Gonzalvo, Erick J Canales-Rodríguez, Laura Blanco, Diana Bachiller, Anna Romaguera, Gemma C Monté-Rubio, Carlos Roncero, Peter J McKenna, Edith Pomarol-Clotet
Background: Structural imaging studies of cannabis users have found evidence of both cortical and subcortical volume reductions, especially in cannabinoid receptor-rich regions such as the hippocampus and amygdala. However, the findings have not been consistent. In the present study, we examined a sample of adult heavy cannabis users without other substance abuse to determine whether long-term use is associated with brain structural changes, especially in the subcortical regions. Method: We compared the gray matter volume of 14 long-term, heavy cannabis users with non-using controls...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29770305/the-prostate-cancer-focal-therapy
#2
REVIEW
Filippo Pesapane, Francesca Patella, Enrico Maria Fumarola, Edoardo Zanchetta, Chiara Floridi, Gianpaolo Carrafiello, Chloë Standaert
Despite prostate cancer (PCa) is the leading form of non-cutaneous cancer in men, most patients with PCa die with disease rather than of the disease. Therefore, the risk of overtreatment should be considered by clinicians who have to distinguish between patients with high risk PCa (who would benefit from radical treatment) and patients who may be managed more conservatively, such as through active surveillance or emerging focal therapy (FT). The aim of FT is to eradicate clinically significant disease while protecting key genito-urinary structures and function from injury...
April 2018: Gland Surgery
https://www.readbyqxmd.com/read/29768414/adipose-derived-mesenchymal-stem-cells-admsc-for-the-treatment-of-secondary-progressive-multiple-sclerosis-a-triple-blinded-placebo-controlled-randomized-phase-i-ii-safety-and-feasibility-study
#3
Oscar Fernández, Guillermo Izquierdo, Victoria Fernández, Laura Leyva, Virginia Reyes, Miguel Guerrero, Antonio León, Carlos Arnaiz, Guillermo Navarro, Maria Dolores Páramo, Antonio De la Cuesta, Bernat Soria, Abdelkrim Hmadcha, David Pozo, Rafael Fernandez-Montesinos, Maria Leal, Itziar Ochotorena, Patricia Gálvez, Maria Angeles Geniz, Francisco Javier Barón, Rosario Mata, Cristina Medina, Carlos Caparrós-Escudero, Ana Cardesa, Natividad Cuende
BACKGROUND: Currently available treatments for secondary progressive multiple sclerosis(SPMS) have limited efficacy and/or safety concerns. Adipose-mesenchymal derived stem cells(AdMSCs) represent a promising option and can be readily obtained using minimally invasive procedures. PATIENTS AND METHODS: In this triple-blind, placebo-controlled study, cell samples were obtained from consenting patients by lipectomy and subsequently expanded. Patients were randomized to a single infusion of placebo, low-dose(1x106cells/kg) or high-dose(4x106cells/kg) autologous AdMSC product and followed for 12 months...
2018: PloS One
https://www.readbyqxmd.com/read/29761009/hippocampal-gray-matter-increases-following-multimodal-psychological-treatment-for-combat-related-post-traumatic-stress-disorder
#4
Oisin Butler, Gerd Willmund, Tobias Gleich, Jürgen Gallinat, Simone Kühn, Peter Zimmermann
Introduction: Smaller hippocampal volumes are one of the most consistent findings in neuroimaging studies of post-traumatic stress disorder (PTSD). However, very few prospective studies have assessed changes in hippocampal gray matter prior to and following therapy for PTSD, and no neuroimaging studies to date have longitudinally assessed military populations. Methods: A pilot study was conducted, assessing patients with combat-related PTSD with structural MRI. Participants were then assigned either to a treatment group or waiting-list control group...
May 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29753641/consistency-of-normalized-cerebral-blood-volume-values-in-glioblastoma-using-different-leakage-correction-algorithms-on-dynamic-susceptibility-contrast-magnetic-resonance-imaging-data-without-and-with-prebolus
#5
Dennis Hedderich, Anne Kluge, Thomas Pyka, Claus Zimmer, Jan S Kirschke, Benedikt Wiestler, Christine Preibisch
BACKGROUND AND PURPOSE: Several leakage correction algorithms for dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI)-based cerebral blood volume (CBV) measurement have been proposed, and combination with a preload of contrast agent is generally recommended. A single bolus application scheme would largely simplify and facilitate standardized clinical applications, while reducing contrast agent (CA) dose. The aim of this study was, therefore, to investigate whether appropriate leakage correction redundantizes prebolus application by comparing normalized DSC-based CBV (nCBV) measures of two consecutive CA boli...
May 10, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29752976/can-dynamic-contrast-enhanced-mri-evaluate-vegf-expression-in-brain-glioma-an-mri-guided-stereotactic-biopsy-study
#6
Ningning Di, Wenna Cheng, Xingyue Jiang, Xinjiang Liu, Jinliang Zhou, Qian Xie, Zhihui Chu, Huacheng Chen, Bin Wang
PURPOSE: To investigate whether pharmacokinetic parameters derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can be used to evaluate vascular endothelial growth factor (VEGF) expression in brain glioma based on a point-to-point basis. MATERIALS AND METHODS: Forty-seven patients with treatment-naïve glioma received preoperative DCE-MRI before stereotactic biopsy. We histologically quantified VEGF from section of stereotactic biopsies, and co-registered biopsy locations with localized measurements of DCE-MRI parameters including volume transfer coefficient (Ktrans ), reverse reflux rate constant (Kep), extracellular extravascular volume fraction (Ve) and blood plasma volume (Vp)...
May 9, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29751184/usefulness-of-ultrasound-guided-microsurgery-in-cavernous-angiomas-removal
#7
Lina Raffaella Barzaghi, Jody Filippo Capitanio, Lodoviga Giudice, Pietro Panni, Stefania Acerno, Pietro Mortini
OBJECT: Primary steps in the cavernous angiomas (CAs) surgery are a precise lesion identification and an optimal trajectory definition. Doing so, navigation techniques allow better results compared to microsurgery alone. In this paper we define the benefits of Intra-Operative Ultra-Sound (IOUS) use in addition to standard localization systems. METHODS: We retrospectively analyzed 59 CAs comparing two groups: 34 cases of frame-based and frameless navigation-assisted microsurgery (no-IOUS group) versus 25 cases of IOUS-guided microsurgery associated with these techniques (IOUS group)...
May 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29748532/semaphorin-4d-correlates-with-increased-bone-resorption-hypercalcemia-and-disease-stage-in-newly-diagnosed-patients-with-multiple-myeloma
#8
Evangelos Terpos, Ioannis Ntanasis-Stathopoulos, Dimitrios Christoulas, Tina Bagratuni, Marios Bakogeorgos, Maria Gavriatopoulou, Evangelos Eleutherakis-Papaiakovou, Nikolaos Kanellias, Efstathios Kastritis, Meletios A Dimopoulos
Multiple myeloma (MM) is characterized by bone destruction due to increased bone resorption and decreased bone formation. Semaphorin 4D (CD100, Sema4D) is expressed by osteoclasts, binds to its receptor Plexin-B1, and acts as a mediator of osteoclast-osteoblast interaction that ultimately inhibits osteoblastic bone formation. Preclinical data suggest that Sema4D/Plexin-B1 pathway is implicated in MM-induced bone disease. However, there is no information on the role of Sema4D in MM patients. Thus, we evaluated Sema4D and Plexin-B1 in six myeloma cells lines in vitro; in the bone marrow plasma (BMP) and serum of 72 newly diagnosed symptomatic MM (NDMM) patients and in 25 healthy controls...
May 11, 2018: Blood Cancer Journal
https://www.readbyqxmd.com/read/29746391/magnetoencephalographic-mapping-of-epileptic-spike-population-using-distributed-source-analysis-comparison-with-intracranial-electroencephalographic-spikes
#9
Naoaki Tanaka, Christos Papadelis, Eleonora Tamilia, Joseph R Madsen, Phillip L Pearl, Steven M Stufflebeam
INTRODUCTION: This study evaluates magnetoencephalographic (MEG) spike population as compared with intracranial electroencephalographic (IEEG) spikes using a quantitative method based on distributed source analysis. METHODS: We retrospectively studied eight patients with medically intractable epilepsy who had an MEG and subsequent IEEG monitoring. Fifty MEG spikes were analyzed in each patient using minimum norm estimate. For individual spikes, each vertex in the source space was considered activated when its source amplitude at the peak latency was higher than a threshold, which was set at 50% of the maximum amplitude over all vertices...
April 27, 2018: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/29745514/-research-development-of-real-time-functional-magnetic-resonance-imaging-neuro-feedback-technology-based-on-brain-network-connectivity
#10
REVIEW
Wenjie He, Haibing Bu, Li Tong, Fuquan Liu, Ying Zeng, Linyuan Wang, Bin Yan
The emergence of real-time functional magnetic resonance imaging (rt-fMRI) has provided foundations for neurofeedback based on brain hemodynamics and has given the new opportunity and challenge to cognitive neuroscience research. Along with the study of advanced brain neural mechanisms, the regulation goal of rt-fMRI neurofeedback develops from the early specific brain region activity to the brain network connectivity more accordant with the brain functional activities, and the study of the latter may be a trend in the area...
June 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29744918/retrospective-analysis-of-rf-heating-measurements-of-passive-medical-implants
#11
Ting Song, Zhiheng Xu, Maria Ida Iacono, Leonardo M Angelone, Sunder Rajan
PURPOSE: The test reports for the RF-induced heating of metallic devices of hundreds of medical implants have been provided to the U.S. Food and Drug Administration as a part of premarket submissions. The main purpose of this study is to perform a retrospective analysis of the RF-induced heating data provided in the reports to analyze the trends and correlate them with implant geometric characteristics. METHODS: The ASTM-based RF heating test reports from 86 premarket U...
May 9, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29740273/childhood-emotional-abuse-moderates-associations-among-corticomotor-white-matter-structure-and-stress-neuromodulators-in-women-with-and-without-depression
#12
Carlton P Frost, M Elizabeth Meyerand, Rasmus M Birn, Roxanne M Hoks, Erin C Walsh, Heather C Abercrombie
Adverse caregiving during development can produce long-lasting changes to neural, endocrine, and behavioral responses to stress, and is strongly related to elevated risk of adult psychopathology. While prior experience of adversity is associated with altered sympathetic nervous system (SNS) and hypothalamic-pituitary-adrenal (HPA) axis activity, the underlying neural pathways are not completely understood. In a double-blind crossover study, we used diffusion tensor imaging (DTI) to examine whether variation in white matter structure predicts differences in HPA-SNS interactions as a function of early adversity...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29739827/hyperfiltration-in-ubiquitin-c-terminal-hydrolase-l1-deleted-mice
#13
Naomi C Boisvert, Chet E Holterman, Jean-François Thibodeau, Rania Nasrallah, Eldjonai Kamto, Cesar H Comin, Luciano da F Costa, Anthony Carter, Richard L Hébert, Alexey Gutsol, Gregory O Cron, Baptiste Lacoste, Douglas A Gray, Chris R Kennedy
Neuronal ubiquitin C-terminal hydrolase L1 (UCHL1) is a deubiquitinating enzyme that maintains intracellular ubiquitin pools and promotes axonal transport. Uchl1 deletion in mice leads to progressive axonal degeneration, affecting the dorsal root ganglion that harbours axons emanating to the kidney. Innervation is a crucial regulator of renal hemodynamics, though the contribution of neuronal UCHL1 to this is unclear. Immunofluorescence revealed significant neuronal UCHL1 expression in mouse kidney, including periglomerular axons...
May 8, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29738390/incidence-and-risk-factors-for-sigmoid-venous-thrombosis-following-cpa-tumor-resection
#14
Matthew Shew, Hannah Kavookjian, Kelly Dahlstrom, Thomas Muelleman, James Lin, Paul Camarata, Luke N Ledbetter, Hinrich Staecker
OBJECTIVE: Our primary aim was to determine the incidence of sigmoid venous thrombosis (SVT) and determine risks factors and sequelae of SVT following cerebellopontine angle tumor resection. STUDY DESIGN: Retrospective cohort study. SETTING: Academic tertiary care hospital. PATIENTS: Patients over 18 years of age who underwent resection of cerebellopontine angle meningioma or vestibular schwannoma from January 2005 to April 2016 who had postoperative magnetic resonance imaging...
June 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29728818/the-3d-reconstructions-of-female-pelvic-autonomic-nerves-and-their-related-organs-based-on-mri-a-first-step-towards-neuronavigation-during-nerve-sparing-radical-hysterectomy
#15
Pengfei Li, Ping Liu, Chunlin Chen, Hui Duan, Wenjun Qiao, Oldevie Hugueth Ognami
OBJECTIVES: To present in vivo female pelvic autonomous innervation and the relationship between nerves and their related organs by three-dimensional (3D) reconstruction based on magnetic resonance imaging (MRI). METHODS: Thirty patients with cervical cancer who underwent pelvic MRI and agreed to undergo additional magnetic resonance neurography (MRN) sequences were enrolled in the present study. MRI images from the same patient were acquired using T2-weighted fat saturation (T2W FS) and 3D-STIR-SPACE sequences...
May 4, 2018: European Radiology
https://www.readbyqxmd.com/read/29728519/first-in-human-pet-study-of-3-novel-tau-radiopharmaceuticals-11-c-ro6924963-11-c-ro6931643-and-18-f-ro6958948
#16
Dean F Wong, Robert Comley, Hiroto Kuwabara, Paul B Rosenberg, Susan M Resnick, Susanne Ostrowitzki, Cristina Vozzi, Frank Boess, Esther Oh, Constantine G Lyketsos, Michael Honer, Luca Gobbi, Gregory Klein, Noble George, Lorena Gapasin, Kelly Kitzmiller, Joshua Roberts, Jeff Sevigny, Ayon Nandi, James R Brasic, Chakradhar Mishra, Madhav Thambisetty, Abhay Moghekar, Anil Mathur, Marilyn Albert, Robert F Dannals, Edilio Borroni
Background: [11 C]RO-963, [11 C]RO-643 and [18 F]RO-948 (previously referred as [11 C]RO6924963, [11 C]RO6931643, and [18 F]RO6958948, respectively) have been reported as promising PET tracers for tau imaging based on in vitro and preclinical PET data (1,2). Here we describe the first human evaluation of these novel radiotracers. Methods: Amyloid PET positive Alzheimer's disease (AD) patients and young healthy subjects (YC) each received two different tau tracers. Dynamic 90 min scans were obtained after bolus injection of [11 C]RO-963, [11 C]RO-643 or [18 F]RO-948...
May 4, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29725746/mri-analysis-of-peripheral-soft-tissue-composition-not-body-mass-index-correlates-with-outcomes-following-anterior-cruciate-ligament-reconstruction
#17
Michael T Milone, Kartik Shenoy, Hien Pham, Laith M Jazrawi, Eric J Strauss
PURPOSE: To utilize MRI to assess the relationship between BMI, peripheral soft tissue composition about the knee, and surgical outcomes in patients undergoing primary ACL reconstruction. It was hypothesized that a fatty periarticular soft tissue composition may be better than BMI at predicting poor outcomes after ACL reconstruction. METHODS: Fifty-eight patients who underwent primary acute ACL reconstruction were identified from the surgical database and their data were retrospectively reviewed...
May 3, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29725307/comparing-reentrant-drivers-predicted-by-image-based-computational-modeling-and-mapped-by-electrocardiographic-imaging-in-persistent-atrial-fibrillation
#18
Patrick M Boyle, Joe B Hakim, Sohail Zahid, William H Franceschi, Michael J Murphy, Edward J Vigmond, Rémi Dubois, Michel Haïssaguerre, Mélèze Hocini, Pierre Jaïs, Natalia A Trayanova, Hubert Cochet
Electrocardiographic mapping (ECGI) detects reentrant drivers (RDs) that perpetuate arrhythmia in persistent AF (PsAF). Patient-specific computational models derived from late gadolinium-enhanced magnetic resonance imaging (LGE-MRI) identify all latent sites in the fibrotic substrate that could potentially sustain RDs, not just those manifested during mapped AF. The objective of this study was to compare RDs from simulations and ECGI (RDsim /RDECGI ) and analyze implications for ablation. We considered 12 PsAF patients who underwent RDECGI ablation...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29722938/-diagnosis-and-treatment-of-ejaculatory-duct-obstruction-current-status-and-advances
#19
REVIEW
Zheng Li, Xiang-Ping Li, Hui-Xing Chen
Ejaculatory duct obstruction (EDO) is one of the obstructive factors for 1-5% of all cases of male infertility and it is, however, surgically correctable. Congenital developmental abnormality is a most common cause of EDO. The clinical manifestations of EDO are varied, typically with the decline of four semen parameters. Transrectal ultrasonography is an important imaging method for the diagnosis of EDO and guidance in its surgery. MRI provides high-resolution images of the reproductive system as evidence...
June 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29716239/reduction-of-sound-evoked-midbrain-responses-observed-by-functional-magnetic-resonance-imaging-following-acute-acoustic-noise-exposure
#20
Bin Yang, Eddie Wong, Wai Hong Ho, Condon Lau, Ying Shing Chan, Ed X Wu
Short duration and high intensity acoustic exposures can lead to temporary hearing loss and auditory nerve degeneration. This study investigates central auditory system function following such acute exposures after hearing loss recedes. Adult rats were exposed to 100 dB sound pressure level noise for 15 min. Auditory brainstem responses (ABRs) were recorded with click sounds to check hearing thresholds. Functional magnetic resonance imaging (fMRI) was performed with tonal stimulation at 12 and 20 kHz to investigate central auditory changes...
April 2018: Journal of the Acoustical Society of America
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