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Vaccine AND side effects

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https://www.readbyqxmd.com/read/28933619/african-american-adults-and-seasonal-influenza-vaccination-changing-our-approach-can-move-the-needle
#1
Sandra Crouse Quinn
Consistent disparities in influenza (flu) vaccine uptake among African Americans, coupled with a disproportionate burden of chronic diseases, places too many African Americans at high risk for complications, hospitalizations and premature mortality. This disparity is the result of individual attitudes and beliefs, social norms, and health care practices. Recent research identifies critical factors affecting vaccine uptake among African American adults including perceived risk of vaccine side effects, social norms that do not support for vaccination, and lower knowledge of the flu and the vaccine...
September 21, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28933242/the-hpv-vaccine-knowledge-and-attitudes-among-public-health-nurses-and-general-practitioners-in-northern-norway-after-introduction-of-the-vaccine-in-the-school-based-vaccination-programme
#2
Karin Nilsen, Olaf Gjerløw Aasland, Elise Klouman
OBJECTIVE: To investigate knowledge of and attitudes to human papillomavirus (HPV) infection, HPV vaccination, cervical cancer, related sources of information and factors associated with willingness to vaccinate one's own daughter among primary health care (PHC) personnel. DESIGN: Cross-sectional study. SETTING: PHC. SUBJECTS: All public health nurses (PHNs) and general practitioners (GPs) in Northern Norway were invited to answer a structured electronic questionnaire; 31% participated (N = 220)...
September 21, 2017: Scandinavian Journal of Primary Health Care
https://www.readbyqxmd.com/read/28930585/leishmaniasis-treatment-update-of-possibilities-for-drug-repurposing
#3
Valter Viana Andrade-Neto, Edezio Ferreira Cunha-Junior, Viviane Dos Santos Faioes, Thaís Martins Pereira, Raphaela Lopes Silva, Leonor Laura Leon, Eduardo Caio Torres-Santos
The leishmaniases represent a public health problem in under-developed countries and are considered a neglected disease by the World Health Organization (WHO). They are cuased by Leishmania  parasites with different clinical manifestations. Currently, there is no vaccine, and treatment is in-efficient and is associated with both serious side effects often leading to resistance to the parasites. Thus, it is essential to search for new treatment strategies, such as drug repurposing, i.e., the use of drugs that are already used for other diseases...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28925936/an-atypical-local-vesicular-reaction-to-the-yellow-fever-vaccine
#4
Robert H Wauters, Camellia L Hernandez, Maureen M Petersen
Yellow fever vaccine is a live attenuated viral inoculation indicated for patients traveling to endemic areas. The vaccine is generally well tolerated with minimal adverse effects. Typical side effects include malaise, pain at the injection site, and, albeit rarely, immediate hypersensitivity reactions. We present a case of a rare adverse reaction to yellow fever vaccine in which a patient developed vesicular lesions resulting in bullae and circumferential hyperpigmentation.
September 19, 2017: Vaccines
https://www.readbyqxmd.com/read/28922786/relapse-free-survival-as-a-surrogate-for-overall-survival-in-the-evaluation-of-stage-ii-iii-melanoma-adjuvant-therapy
#5
Stefan Suciu, Alexander M M Eggermont, Paul Lorigan, John M Kirkwood, Svetomir N Markovic, Claus Garbe, David Cameron, Srividya Kotapati, Tai-Tsang Chen, Keith Wheatley, Natalie Ives, Gaetan de Schaetzen, Achmad Efendi, Marc Buyse
Background: We assessed whether relapse-free survival (RFS; time until recurrence/death) is a valid surrogate for overall survival (OS) among resected stage II-III melanoma patients through a meta-analysis of randomized controlled trials. Methods: Individual patient data (IPD) on RFS and OS were collected from 5826 patients enrolled in 11 randomized adjuvant trials comparing interferon (IFN) to observation. In addition, IPD from two studies comparing IFN and vaccination in 989 patients were included...
January 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28915908/advances-in-paediatrics-in-2016-current-practices-and-challenges-in-allergy-autoimmune-diseases-cardiology-endocrinology-gastroenterology-infectious-diseases-neonatology-nephrology-neurology-nutrition-pulmonology
#6
REVIEW
Carlo Caffarelli, Francesca Santamaria, Dora Di Mauro, Carla Mastrorilli, Silvia Montella, Sergio Bernasconi
This review reports main progresses in various pediatric issues published in Italian Journal of Pediatrics and in international journals in 2016. New insights in clinical features or complications of several disorders may be useful for our better understanding. They comprise severe asthma, changing features of lupus erythematosus from birth to adolescence, celiac disease, functional gastrointestinal disorders, Moebius syndrome, recurrent pneumonia. Risk factors for congenital heart defects, Kawasaki disease have been widely investigated...
September 16, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28915100/promotion-of-immunizations-for-health-professionals-in-europe-a-qualitative-study-in-seven-european-member-states
#7
Archontoula Dalma, Pania Karnaki, Agoritsa Baka, Vasilios Raftopoulos, Dina Zota, Afroditi Veloudaki, Amanda Garrison, Paloma Ellis Montalban, Zainub Dhanani, Athena Linos
Health Care Workers (HCWs) are a high-risk group for contracting Vaccine-Preventable Diseases who, despite legislation and guidance, remain undervaccinated. In order to understand their barriers and needs, focus groups were formed with 278 physicians, nurses, infection-control personnel, and policy-makers in 7 EU MS. Several implications for the development of promotional initiatives were identified including the need to overcome organizational barriers, to sensitize HCWs about the importance of immunization and to provide specific up-to-date information about vaccinations covering prevalence of diseases, protection years, side effects, administration times, antibody examinations, costs and immunization settings...
September 15, 2017: Hospital Topics
https://www.readbyqxmd.com/read/28900348/improvement-in-vaccination-knowledge-among-health-students-following-an-integrated-extra-curricular-intervention-an-explorative-study-in-the-university-of-palermo
#8
REVIEW
C Marotta, D D Raia, G Ventura, N Casuccio, F Dieli, C D'Angelo, V Restivo, C Costantino, F Vitale, A Casuccio
INTRODUCTION: Vaccination coverages threaten to decrease because of false beliefs in their unsafety and inefficacy. Therefore formation of future health-care workers on this topic is fundamental to deal with any doubt and to promote active immunization among general population. METHODS: In order to assess health-care students' knowledge about vaccination before an integrated seminar on this topic, and to evaluate their improvement after the educational intervention, an integrated educational intervention was held by a multidisciplinary team...
June 2017: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/28898512/knowledge-attitudes-and-opinions-towards-measles-and-the-mmr-vaccine-across-two-nsw-cohorts
#9
Daniel Brieger, Matthew Edwards, Poonam Mudgil, John Whitehall
OBJECTIVE: Although the number of national measles cases has greatly decreased since 1980s, there has been resurgence in disease incidence in recent years. While parental knowledge and attitudes toward both disease and vaccinations are known to influence vaccine uptake, the contribution of these factors toward vaccination rates in NSW populations has not been studied. The aim of this study was to investigate the knowledge and opinions on measles and MMR vaccine in NSW Central and North Coast regions...
September 12, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/28894188/second-generation-flagellin-rpac-fusion-protein-kfd2-rpac-shows-high-protective-efficacy-against-dental-caries-with-low-potential-side-effects
#10
Jingyi Yang, Ying Sun, Rong Bao, Dihan Zhou, Yi Yang, Yuan Cao, Jie Yu, Bali Zhao, Yaoming Li, Huimin Yan, Maohua Zhong
Dental caries is one of the most common global chronic diseases affecting all ages of the population; thus a vaccine against caries is urgently needed. Our previous studies demonstrated that a fusion protein, KF-rPAc, in which rPAc of S. mutans is directly fused to the C-terminal of E. coli-derived flagellin (KF), could confer high prophylactic and therapeutic efficiency against caries. However, possible side effects, including the high antigenicity of flagellin and possible inflammatory injury induced by flagellin, may restrict its clinical usage...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28892673/human-papillomavirus-knowledge-and-vaccine-acceptability-among-adolescents-in-a-greek-region
#11
P A Anagnostou, V H Aletras, D A Niakas
OBJECTIVES: The aim of this research was twofold: (1) develop an instrument to assess knowledge regarding human papillomavirus (HPV) and its vaccine and utilize this instrument to measure knowledge levels of Greek adolescents in Lyceum schools of Western Thessaloniki; and (2) examine the associations of the resultant knowledge measure scores with sociodemographic characteristics. STUDY DESIGN: Cross-sectional survey with complex sampling design. METHODS: A total of 268 students of three Lyceum schools in Western Thessaloniki responded anonymously to a questionnaire during February-March 2013...
September 8, 2017: Public Health
https://www.readbyqxmd.com/read/28888648/evaluation-of-the-effect-of-a-porcine-reproductive-and-respiratory-syndrome-prrs-modified-live-virus-vaccine-on-sow-reproductive-performance-in-endemic-prrs-farms
#12
Jiwoon Jeong, Seeun Kim, Kee Hwan Park, Ikjae Kang, Su-Jin Park, Changhoon Park, Chanhee Chae
The efficacy of a porcine reproductive and respiratory syndrome (PRRS) modified-live virus vaccine in reproductive performance was evaluated under field conditions. Three PRRS endemic farms were selected based on their history of PRRS-associated reproductive failures. On each farm, a total of 40 sows were randomly allocated to either vaccinated (n=20) or unvaccinated (n=20) groups. Sows were vaccinated six weeks prior to breeding. Clinical data showed a significant improvement in reproductive performance in vaccinated sows...
September 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28886882/insights-into-defective-serological-memory-after-acute-lymphoblastic-leukaemia-treatment-the-role-of-the-plasma-cell-survival-niche-memory-b-cells-and-gut-microbiota-in-vaccine-responses
#13
REVIEW
Shanie Saghafian-Hedengren, Ismael Söderström, Eva Sverremark-Ekström, Anna Nilsson
Acute lymphoblastic leukaemia (ALL) is the most common type of cancer in children, accounting for approximately 25% of childhood cancer cases. As a result of effective treatments over the past decades, paediatric ALL mortality has been greatly reduced. Chemotherapy, however, has a range of harmful side effects including the loss of protective antibodies against vaccine-preventable diseases. Since ALL survivors have an increased risk of health problems including organ insufficiencies, acquired vaccine-preventable infections subsequent to clinical remission could become life threatening to these individuals...
August 26, 2017: Blood Reviews
https://www.readbyqxmd.com/read/28882437/dna-vaccines-against-leptospirosis-a-literature-review
#14
REVIEW
Marcelle Moura Silveira, Thaís Larré Oliveira, Rodrigo Andrade Schuch, Alan John Alexander McBride, Odir Antônio Dellagostin, Daiane Drawanz Hartwig
Leptospirosis is an infectious disease caused by pathogenic Leptospira species. The vaccines that are currently available for leptospirosis are composed of whole-cell preparations and suffer from limitations such as low efficacy, multiple side-effects, poor immunological memory and lack of cross-protection against different serovars of Leptospira spp. In light of the global prevalence of this disease, the development of a more effective vaccine against leptospirosis is of paramount importance. Genetic immunization is a promising alternative to conventional vaccine development...
September 4, 2017: Vaccine
https://www.readbyqxmd.com/read/28866467/cta1-purified-and-display-onto-gram-positive-enhancer-matrix-gem-particles-as-mucosal-adjuvant
#15
Yuanpeng Zhang, Xiaoming Yu, Liting Hou, Jin Chen, Pengcheng Li, Xuwen Qiao, Qisheng Zheng, Jibo Hou
The A1 subunit of cholera toxin (CTA1) retains the adjuvant function of CT, without its toxic side effects, making the molecule a promising mucosal adjuvant. However, the methods required to obtain a pure product are both complicated and expensive, constricting its potential commercial applicability. Here, we fused the peptidoglycan binding domain (PA) to the C-terminus of CTA1, which enabled the fusion protein to be expressed by Bacillus subtilis, and secreted into the culture medium. CTA1 was then purified and displayed on GEM particles using a one step process, which resulted in the formation of CTA1-GEM complexes...
September 1, 2017: Protein Expression and Purification
https://www.readbyqxmd.com/read/28857349/factors-that-influence-influenza-vaccination-rates-among-the-elderly-nurses-perspectives
#16
Moriah Ellen
AIMS: To explore which factors nurses perceive to help and hinder influenza vaccination rates among the elderly. BACKGROUND: Influenza-related illnesses and deaths have disproportionately high prevalence among the elderly. Vaccination is an effective tool to prevent complications. METHODS: Semistructured interviews were conducted with nurses focusing on barriers, facilitators and health care providers' roles in influencing patients to be vaccinated...
August 30, 2017: Journal of Nursing Management
https://www.readbyqxmd.com/read/28856597/chemical-genetics-based-development-of-small-molecules-targeting-hepatitis-c-virus
#17
REVIEW
Guanghai Jin, Jisu Lee, Kyeong Lee
Hepatitis C virus (HCV) infection is a major worldwide problem that has emerged as one of the most significant diseases affecting humans. There are currently no vaccines or efficient therapies without side effects, despite today's advanced medical technology. Currently, the common therapy for most patients (i.e. genotype 1) is combination of HCV-specific direct-acting antivirals (DAAs). Up to 2011, the standard of care (SOC) was a combination of peg-IFNα with ribavirin (RBV). After approval of NS3/4A protease inhibitor, SOC was peg-IFNα and RBV with either the first-generation DAAs boceprevir or telaprevir...
August 30, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28854964/perceptions-of-human-papillomavirus-vaccination-of-adolescent-schoolgirls-in-western-uganda-and-their-implications-for-acceptability-of-hpv-vaccination-a-qualitative-study
#18
Andrew Kampikaho Turiho, Elialilia Sarikieli Okello, Wilson Winstons Muhwezi, Anne Ruhweza Katahoire
BACKGROUND: Human papillomavirus (HPV) vaccination has been perceived in diverse ways some of which encourage its uptake while others could potentially deter its acceptability. This study explored community member's perceptions about HPV vaccination in Ibanda district and the implications of the perceptions for acceptability of HPV vaccination. The study was conducted following initial vaccination of adolescent schoolgirls in the district between 2008 and 2011. METHODS: This qualitative study employed focus group discussions (FGDs) and key informant interviews (KIIs)...
August 30, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28853984/next-generation-immunotherapy-for-tree-pollen-allergies
#19
Yan Su, Eliezer Romeu-Bonilla, Teri Heiland
Tree pollen induced allergies are one of the major medical and public health burdens in the industrialized world. Allergen-Specific Immunotherapy (AIT) through subcutaneous injection or sublingual delivery is the only approved therapy with curative potential to pollen induced allergies. AIT often is associated with severe side effects and requires long-term treatment. Safer, more effective and convenient allergen specific immunotherapies remain an unmet need. In this review article, we discuss the current progress in applying protein and peptide-based approaches and DNA vaccines to the clinical challenges posed by tree pollen allergies through the lens of preclinical animal models and clinical trials, with an emphasis on the birch and Japanese red cedar pollen induced allergies...
August 30, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28842994/safety-and-immunogenicity-of-the-novel-seasonal-preservative-and-adjuvant-free-influenza-vaccine-blind-randomized-and-placebo-controlled-trial
#20
Gulbanu Sarsenbayeva, Yevgeniy Volgin, Markhabat Kassenov, Timur Issagulov, Nikolay Bogdanov, Abylay Sansyzbay, Ruslan Abitay, Ainur Nurpeisova, Altynay Sagymbay, Zhumagali Koshemetov, Marina Stukova, Zhanna Buzitskaya, Ilyas Кulmagambetov, Dinara Karabayeva, Timur Davlyatshin, Berik Khairullin
The producers of influenza vaccines are not capable today to meet the global demand for an influenza vaccine in case of pandemic, so the World Health Organization recommends to develop the own influenza vaccine production in each country. A domestic preservative- and adjuvant-free trivalent split vaccine against seasonal influenza was developed at the Research Institute for Biological Safety Problems. The paper presents the results of assessing safety and immunogenicity of the influenza split vaccine after single immunization of healthy volunteers aged 18-50 years in the course of Phase I Clinical Trials...
August 26, 2017: Journal of Medical Virology
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