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Vaccine AND side effects

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https://www.readbyqxmd.com/read/28103328/a-pre-clinical-safety-evaluation-of-sbp-hbsag-binding-protein-adjuvant-for-hepatitis-b-vaccine
#1
Jingbo Wang, Caixia Su, Rui Liu, Baoxiu Liu, Inam Ullah Khan, Jun Xie, Naishuo Zhu
Although adjuvants are a common component of many vaccines, there are few adjuvants licensed for use in humans due to concerns about their toxic effects. There is a need to develop new and safe adjuvants, because some existing vaccines have low immunogenicity among certain patient groups. In this study, SBP, a hepatitis B surface antigen binding protein that was discovered through screening a human liver cDNA expression library, was introduced into hepatitis B vaccine. A good laboratory practice, non-clinical safety evaluation was performed to identify the side effects of both SBP and SBP-adjuvanted hepatitis B vaccine...
2017: PloS One
https://www.readbyqxmd.com/read/28093104/faecal-shedding-of-canine-parvovirus-after-modified-live-vaccination-in-healthy-adult-dogs
#2
M Freisl, S Speck, U Truyen, S Reese, A-L Proksch, K Hartmann
Since little is known about the persistence and faecal shedding of canine parvovirus (CPV) in dogs after modified-live vaccination, diagnostic tests for CPV can be difficult to interpret in the post-vaccination period. The primary aim of this study was to determine the incidence, duration and extent of CPV vaccine virus shedding in adult dogs and to investigate related factors, including the presence of protective antibodies, increase in anti-CPV antibody titres and development of any gastrointestinal side-effects...
January 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28092214/treatment-of-delta-hepatitis-today-and-in-the-future-a-review
#3
Ibrahim Halil Bahcecioglu, Abdurrahman Sahin
Hepatitis delta virus (HDV) is a defective satellite virus and propagates in the presence of Hepatitis B virus (HBV) surface antigen (HBsAg). Approximately 5% of the people who infected with HBV are also infected with HDV. Chronic hepatitis caused by delta is the most severe form of chronic viral hepatitis including accelerated fibrosis, liver decompensation and development of hepatocellular carcinoma. Interferon-based therapies still remain the only treatment option of the hepatitis delta. The beneficiary effects of the interferon-based therapies, however, stop frequently with termination of the given therapy and relapse rate is very high...
January 16, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28088990/prevention-and-management-of-glucocorticoid-induced-side-effects-a-comprehensive-review-infectious-complications-and-vaccination-recommendations
#4
REVIEW
Avrom Caplan, Nicole Fett, Misha Rosenbach, Victoria P Werth, Robert G Micheletti
Part 3 of this 4-part continuing medical education series reviews several important infectious complications of corticosteroid use, including a focus on pneumocystis pneumonia (PCP) prophylaxis, tuberculosis, viral hepatitis, and other infections, followed by a discussion of vaccination recommendations in immunosuppressed patients.
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28076955/post-translational-modifications-of-trypanosoma-cruzi-canonical-and-variant-histones
#5
Gisele F A Picchi, Vanessa Zulkievicz, Marco Aurelio Krieger, Nilson T Zanchin, Samuel Goldenberg, Lyris M F de Godoy
Chagas disease, caused by Trypanosoma cruzi, still affects millions of people around the world. No vaccines neither treatment for chronic Chagas disease are available, and chemotherapy for the acute phase is hindered by limited efficacy and severe side effects. The processes by which the parasite acquires infectivity and survives in different hosts involve tight regulation of gene expression, mainly post-transcriptionally. Nevertheless, chromatin structure/organization of trypanosomatids is similar to other eukaryotes, including histone variants and post-translational modifications...
January 11, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28057259/modified-vaccinia-virus-ankara-history-value-in-basic-research-and-current-perspectives-for-vaccine-development
#6
REVIEW
A Volz, G Sutter
Safety tested Modified Vaccinia virus Ankara (MVA) is licensed as third-generation vaccine against smallpox and serves as a potent vector system for development of new candidate vaccines against infectious diseases and cancer. Historically, MVA was developed by serial tissue culture passage in primary chicken cells of vaccinia virus strain Ankara, and clinically used to avoid the undesirable side effects of conventional smallpox vaccination. Adapted to growth in avian cells MVA lost the ability to replicate in mammalian hosts and lacks many of the genes orthopoxviruses use to conquer their host (cell) environment...
2017: Advances in Virus Research
https://www.readbyqxmd.com/read/28038325/synthesis-biological-characterisation-and-structure-activity-relationships-of-aromatic-bisamidines-active-against-plasmodium-falciparum
#7
B Sauer, T S Skinner-Adams, A Bouchut, M J Chua, C Pierrot, F Erdmann, D Robaa, M Schmidt, J Khalife, K T Andrews, W Sippl
Malaria is one of the most significant tropical diseases and remains a major challenge due to the lack of a broadly effective vaccine and parasite resistance to current drugs. This means there is a need for new drug candidates with novel modes of action. Aromatic bisamidines, such as furamidine (DB75), were initially developed as anti-Trypanosoma agents however as clinical trials with furamidine highlighted potential side effects they were not pursued further in that setting. Despite apparent cytotoxicity liabilities the potency of furamidine against Plasmodium falciparum makes it a promising scaffold for the development of new anti-Plasmodium agents with improved selectivity...
December 23, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28035738/predictors-for-and-coverage-of-influenza-vaccination-among-hiv-positive-patients-a-cross-sectional-survey
#8
N Harrison, W Poeppl, H Herkner, K D Tillhof, K Grabmeier-Pfistershammer, A Rieger, C Forstner, H Burgmann, H Lagler
OBJECTIVES: Influenza vaccination is recommended for HIV-infected patients, but limited data about vaccination rates are available. The aim of this study was to evaluate the coverage of and predictors for influenza vaccination among HIV-positive patients. METHODS: All HIV-positive patients who visited the HIV out-patient department of the University Hospital of Vienna, Austria, between June and August 2015 were asked to participate in this survey by completing a questionnaire...
December 30, 2016: HIV Medicine
https://www.readbyqxmd.com/read/28035107/antimalarial-efficacy-of-low-molecular-weight-chitosan-against-plasmodium-berghei-infection-in-mice
#9
Aref Teimouri, Afsane Motevalli Haghi, Mehdi Nateghpour, Leila Farivar, Haleh Hanifian, Sara Ayazian Mavi, Roghayeh Zare
BACKGROUND & OBJECTIVES: Despite continuous global attempts to fight parasitic infections, malaria still remains one of the major human life threatening diseases. Difficulty of producing efficient antimalaria vaccines and increasing drug-resistant strains, highlight the urgent need to search for a new alternative antimalaria drug. The aim of this study was to find a new agent against malaria parasite with maximum efficacy and minimum range of side-effects. For this, the antiplasmodial activity of commercial chitosan, a natural carbohydrate polymer, was evaluated on Plasmodium berghei via in vivo experiments...
October 2016: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/27993173/the-immunological-characteristics-and-probiotic-function-of-recombinant-bacillus-subtilis-spore-expressing-clonorchis-sinensis-cysteine-protease
#10
Zeli Tang, Mei Shang, Tingjin Chen, Pengli Ren, Hengchang Sun, Hongling Qu, Zhipeng Lin, Lina Zhou, Jinyun Yu, Hongye Jiang, Xinyi Zhou, Xuerong Li, Yan Huang, Jin Xu, Xinbing Yu
BACKGROUND: Clonorchiasis, a food-borne zoonosis, is caused by Clonorchis sinensis. The intestinal tract and bile ducts are crucial places for C. sinensis metacercariae to develop into adult worms. The endospore of Bacillus subtilis is an ideal oral immunization vehicle for delivery of heterologous antigens to intestine. Cysteine protease of C. sinensis (CsCP) is an endogenous key component in the excystment of metacercariae and other physiological or pathological processes. METHODS: We constructed a fusion gene of CotC (a coat protein)-CsCP and obtained B...
December 19, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27983896/how-often-people-google-for-vaccination-qualitative-and-quantitative-insights-from-a-systematic-search-of-the-web-based-activities-using-google-trends
#11
Nicola Luigi Bragazzi, Ilaria Barberis, Roberto Rosselli, Vincenza Gianfredi, Daniele Nucci, Massimo Moretti, Tania Salvatori, Gianfranco Martucci, Mariano Martini
Nowadays, more and more people surf the Internet seeking health-related information. Information and communication technologies (ICTs) can represent an important opportunities in the field of Public Health and vaccinology. The aim of our current research was to investigate a) how often people search the Internet for vaccination-related information, b) if this search is spontaneous or induced by media, and c) which kind of information is in particular searched. We used Google Trends (GT) for monitoring the interest for preventable infections and related vaccines...
December 16, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27978802/novel-antibacterial-compounds-and-their-drug-targets-successes-and-challenges
#12
Agnieszka A Kaczor, Andrzej Polski, Karolina Sobótka-Polska, Anna Pachuta-Stec, Magdalena Makarska-Bialokoz, Monika Pitucha
Infectious diseases are one of the most important and urgent health problems in the world. According to the World Health Organization (WHO) statistics, infectious and parasitic diseases are a cause of about 16% of all deaths worldwide and over 40% of deaths in Africa. A considerable progress that has been made during last hundred years in the fight against infectious diseases, in particular bacterial infections, can be attributed mainly to three factors: (1) the general improvement of living conditions, in particular sanitation; (2) development of vaccines and (3) development of efficient antibacterial drugs...
December 12, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27974063/leishmaniasis-and-various-immunotherapeutic-approaches
#13
Y Taslimi, F Zahedifard, S Rafati
Leishmaniasis is a vector-borne infectious disease caused by multiple Leishmania (L.) species with diverse clinical manifestations. There is currently no vaccine against any form of the disease approved in humans, and chemotherapy is the sole approach for treatment. Unfortunately, treatment options are limited to a small number of drugs, partly due to high cost and significant adverse effects. The other obstacle in leishmaniasis treatment is the potential for drug resistance, which has been observed in multiple endemic countries...
December 15, 2016: Parasitology
https://www.readbyqxmd.com/read/27957697/benefit-of-slit-and-scit-for-allergic-rhinitis-and-asthma
#14
REVIEW
Giovanni Passalacqua, Giorgio Walter Canonica, Diego Bagnasco
Allergen immunotherapy (AIT) has been in use since more than one century, when Leonard Noon experimentally proved its efficacy in hayfever (Noon, in Lancet 1:1572-3, 1911). Since then, AIT was administered only as subcutaneous injections (SCIT) until the sublingual route (SLIT) was proposed in 1986. The use of SLIT was proposed following several surveys from the USA and UK that repeatedly reported fatalities due to SCIT (Lockey et al. in J Allergy Clin Immunol 75(1): 166, 1985; Lockey et al. in J Allergy Clin Immunol 660-77, 1985; Committee on the safety of medicines...
November 2016: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/27932052/factors-associated-with-parents-attitudes-to-the-hpv-vaccination-of-their-adolescent-sons-a-systematic-review
#15
REVIEW
Gorjana Radisic, Janine Chapman, Ingrid Flight, Carlene Wilson
OBJECTIVE: The objective of the study was to identify factors associated with human papilloma virus (HPV) vaccine acceptability in parents of adolescent boys. This information is critical to the development of approaches to optimise HPV vaccine uptake among this population group. METHODS: We performed a systematic search of the literature in addressing factors influencing parental attitudes to and beliefs about HPV vaccine and its acceptability for use. The findings were organised within the framework of the Health Belief Model (HBM) and summarised using a semi quantitative method...
December 6, 2016: Preventive Medicine
https://www.readbyqxmd.com/read/27919863/applying-multiple-data-collection-tools-to-quantify-human-papillomavirus-vaccine-communication-on-twitter
#16
Philip M Massey, Amy Leader, Elad Yom-Tov, Alexandra Budenz, Kara Fisher, Ann C Klassen
BACKGROUND: Human papillomavirus (HPV) is the most common sexually transmitted infection in the United States. There are several vaccines that protect against strains of HPV most associated with cervical and other cancers. Thus, HPV vaccination has become an important component of adolescent preventive health care. As media evolves, more information about HPV vaccination is shifting to social media platforms such as Twitter. Health information consumed on social media may be especially influential for segments of society such as younger populations, as well as ethnic and racial minorities...
December 5, 2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27914142/attitudes-regarding-hpv-vaccinations-of-children-among-mothers-with-adolescent-daughters-in-korea
#17
Kyong No Lee, Kylie Hae Jin Chang, Seong Sik Cho, Sung Ho Park, Sung Taek Park
The aim of this study, carried out before the beginning of human papillomavirus (HPV) vaccinations as a National Immunization Program (NIP) in Korea in 2016, is to assess the ranges of perceptions and personal experience and their influences on attitudes regarding HPV vaccinations of children, among mothers of adolescent (9-14 years of age) daughters in Korea. From November 2015 to February 2016, we distributed a written questionnaire to mothers who had daughters aged 9-14 years. The questionnaire consisted of several questions, related to knowledge of HPV, personal experiences of HPV vaccination, and attitudes toward HPV vaccinations of their adolescent daughters...
January 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27913692/factors-motivating-hpv-vaccine-uptake-among-vaccinated-and-nonvaccinated-hispanic-young-adult-women
#18
Dionne P Stephens, Hod Tamir, Tami L Thomas
INTRODUCTION: To identify factors influencing human papillomavirus (HPV) vaccination up taking decision making among vaccinated and nonvaccinated Hispanic college women. PARTICIPANTS: Hispanic young women between the ages of 18 and 24 years (N = 49). In total, 26 had not received the HPV vaccine, and 23 had started/completed the vaccine series. METHOD: Participants registered for the study via a psychology research pool at a large public university in the southeast United States after institutional review board approval...
December 2016: Hispanic Health Care International: the Official Journal of the National Association of Hispanic Nurses
https://www.readbyqxmd.com/read/27910798/a-qualitative-study-of-women-who-experience-side-effects-from-human-papillomavirus-vaccination
#19
Tina Sørensen, Pernille Tanggaard Andersen
INTRODUCTION: In Denmark, vaccination against human papillomavirus (HPV) is offered to girls and women to prevent cervical cancer. Unfortunately, reporting of possible side effects from vaccination has increased in recent years. Therefore, the present study examine women's experiences of side effects from the HPV vaccine. METHODS: In-depth qualitative interviews were conducted with eight HPV-vaccinated Danish women, aged 25-44 years, who experienced side effects from the vaccine...
December 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27893068/immunogenicity-of-the-9-valent-hpv-vaccine-using-2-dose-regimens-in-girls-and-boys-vs-a-3-dose-regimen-in-women
#20
Ole-Erik Iversen, Maria Jose Miranda, Angels Ulied, Terje Soerdal, Erica Lazarus, Kulkanya Chokephaibulkit, Stan L Block, Ales Skrivanek, Abdul Ghani Nur Azurah, Siew Moy Fong, Vladimir Dvorak, Kyung-Hyo Kim, Ramon M Cestero, Matitiahu Berkovitch, Mehmet Ceyhan, Misoo C Ellison, Michael A Ritter, Shuai S Yuan, Mark J DiNubile, Alfred J Saah, Alain Luxembourg
Importance: Human papillomavirus (HPV) infections cause anogenital cancers and warts. The 9-valent HPV vaccine provides protection against 7 high-risk types of HPV responsible for 90% of cervical cancers and 2 other HPV types accounting for 90% of genital warts. Objective: To determine whether HPV type-specific antibody responses would be noninferior among girls and boys aged 9 to 14 years after receiving 2 doses of the 9-valent HPV vaccine compared with adolescent girls and young women aged 16 to 26 years receiving 3 doses...
13, 2016: JAMA: the Journal of the American Medical Association
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