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Vaccine AND side effects

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https://www.readbyqxmd.com/read/28324748/influenza-vaccination-in-adult-patients-with-solid-tumours-treated-with-chemotherapy
#1
REVIEW
Albert Vollaard, Imke Schreuder, Lizzy Slok-Raijmakers, Wim Opstelten, Guus Rimmelzwaan, Hans Gelderblom
Patients with solid tumours receiving chemotherapy are at risk for influenza complications. Yearly influenza vaccination is recommended to patients treated with chemotherapy. However, adherence to vaccination is low, most likely due to lack of data on efficacy, optimal timing and safety of vaccination. There is scarce evidence for the effectiveness of the influenza vaccine in adult patients with solid tumours and chemotherapy on reduction of pneumonia, decreased mortality and fewer interruptions of oncological treatment...
March 16, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28317886/systems-pharmacology-based-strategy-to-screen-new-adjuvant-for-hepatitis-b-vaccine-from-traditional-chinese-medicine-ophiocordyceps-sinensis
#2
Jingbo Wang, Rui Liu, Baoxiu Liu, Yan Yang, Jun Xie, Naishuo Zhu
Adjuvants are common component for many vaccines but there are still few licensed for human use due to low efficiency or side effects. The present work adopted Systems Pharmacology analysis as a new strategy to screen adjuvants from traditional Chinese medicine. Ophiocordyceps sinensis has been used for many years in China and other Asian countries with many biological properties, but the pharmacological mechanism has not been fully elucidated. First in this study, 190 putative targets for 17 active compounds in Ophiocordyceps sinensis were retrieved and a systems pharmacology-based approach was applied to provide new insights into the pharmacological actions of the drug...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28314047/the-role-of-risk-perception-in-flu-vaccine-behavior-among-african-american-and-white-adults-in-the-united-states
#3
Vicki S Freimuth, Amelia Jamison, Gregory Hancock, Donald Musa, Karen Hilyard, Sandra Crouse Quinn
Seasonal flu vaccination rates are low for U.S. adults, with significant disparities between African and white Americans. Risk perception is a significant predictor of vaccine behavior but the research on this construct has been flawed. This study addressed critical research questions to understand the differences between African and white Americans in the role of risk perception in flu vaccine behavior: (1) What is the dimensionality of risk perception and does it differ between the two races?  (2) Were risk perceptions of white and African-American populations different and how were sociodemographic characteristics related to risk for each group? (3) What is the relation between risk perception and flu vaccine behaviors for African Americans and whites? The sample, drawn from GfK's Knowledge Panel, consisted of 838 whites and 819 African Americans...
March 17, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28304339/the-five-immune-forces-impacting-dna-based-cancer-immunotherapeutic-strategy
#4
REVIEW
Suneetha Amara, Venkataswarup Tiriveedhi
DNA-based vaccine strategy is increasingly realized as a viable cancer treatment approach. Strategies to enhance immunogenicity utilizing tumor associated antigens have been investigated in several pre-clinical and clinical studies. The promising outcomes of these studies have suggested that DNA-based vaccines induce potent T-cell effector responses and at the same time cause only minimal side-effects to cancer patients. However, the immune evasive tumor microenvironment is still an important hindrance to a long-term vaccine success...
March 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28302411/immunogenicity-and-safety-of-a-quadrivalent-inactivated-influenza-vaccine-compared-with-two-trivalent-inactivated-influenza-vaccines-containing-alternate-b-strains-in-adults-a-phase-3-randomized-noninferiority-study
#5
John T Treanor, Frank R Albano, Daphne C Sawlwin, Alison Graves Jones, Jolanta Airey, Neil Formica, Vince Matassa, Jane Leong
BACKGROUND: Vaccination is the most effective means of influenza prevention. Efficacy of trivalent vaccines may be enhanced by including both B strain lineages. This phase 3, double-blind study assessed the immunogenicity and safety/tolerability of a quadrivalent inactivated influenza vaccine (IIV4) versus the United States (US)-licensed 2014-2015 trivalent inactivated influenza vaccine (IIV3-Yamagata [IIV3-YAM]; Afluria) and IIV3 containing the alternate Victoria B strain (IIV3-VIC) in adults ≥18years...
March 13, 2017: Vaccine
https://www.readbyqxmd.com/read/28301479/ligb-subunit-vaccine-confers-sterile-immunity-against-challenge-in-the-hamster-model-of-leptospirosis
#6
Neida L Conrad, Flávia W Cruz McBride, Jéssica D Souza, Marcelle M Silveira, Samuel Félix, Karla S Mendonça, Cleiton S Santos, Daniel A Athanazio, Marco A Medeiros, Mitermayer G Reis, Odir A Dellagostin, Alan J A McBride
Neglected tropical diseases, including zoonoses such as leptospirosis, have a major impact on rural and poor urban communities, particularly in developing countries. This has led to major investment in antipoverty vaccines that focus on diseases that influence public health and thereby productivity. While the true, global, impact of leptospirosis is unknown due to the lack of adequate laboratory diagnosis, the WHO estimates that incidence has doubled over the last 15 years to over 1 million cases that require hospitalization every year...
March 16, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28293422/regional-disparities-in-immunization-services-in-ghana-through-a-bottleneck-analysis-approach-implications-for-sustaining-national-gains-in-immunization
#7
A E Yawson, G Bonsu, L K Senaya, A O Yawson, J B Eleeza, J K Awoonor-Williams, H K Banskota, E E A Agongo
BACKGROUND: Immunization is considered one of the most cost effective public health interventions for reducing child morbidity, mortality and disability. The aim of this work is to describe the application of the Bottleneck analysis (BNA) process to assess gaps in immunization services in Ghana and implications for sustaining the gains in Immunization coverage. METHODS: A national assessment was conducted in May 2015, through use of desk reviews, field visits and key informant interviews...
2017: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/28291647/health-professional-feedback-on-hpv-vaccination-roll-out-in-a-developing-country
#8
Collette Venturas, Kanayo Umeh
BACKGROUND: Worldwide, Zambia has the highest cervical cancer incidence rates (58.4/100,000 per year) and mortality rates (36.2/100,000 per year). The human papilloma virus (HPV) vaccine is considered a vital preventative measure against cervical cancer, particularly in sub-Saharan countries, such as Zambia. Past research suggests health professionals' experiences with HPV vaccination rollout can have practical implications for effective delivery. OBJECTIVE: To explore health professionals' perspectives on the HPV vaccination programme in Zambia...
March 10, 2017: Vaccine
https://www.readbyqxmd.com/read/28284680/psychological-factors-associated-with-uptake-of-the-childhood-influenza-vaccine-and-perception-of-post-vaccination-side-effects-a-cross-sectional-survey-in-england
#9
Louise E Smith, Rebecca K Webster, John Weinman, Richard Amlôt, Jenny Yiend, G James Rubin
OBJECTIVES: To identify predictors of: uptake of the childhood influenza vaccine in the 2015-2016 influenza season, parental perceptions of side-effects from the influenza vaccine and intention to vaccinate one's child for influenza in the 2016-2017 influenza season. DESIGN: Cross-sectional online survey. SETTING: Data were collected in England shortly after the end of the 2015-2016 immunization campaign. PARTICIPANTS: 1001 parents or guardians of children aged between two and seven...
February 24, 2017: Vaccine
https://www.readbyqxmd.com/read/28249006/assessments-of-global-drivers-of-vaccine-hesitancy-in-2014-looking-beyond-safety-concerns
#10
Melanie Marti, Monica de Cola, Noni E MacDonald, Laure Dumolard, Philippe Duclos
Vaccine hesitancy has become the focus of growing attention and concern globally despite overwhelming evidence of the value of vaccines in preventing disease and saving the lives of millions of individuals every year. Measuring vaccine hesitancy and its determinants worldwide is important in order to understand the scope of the problem and for the development of evidence-based targeted strategies to reduce hesitancy. Two indicators to assess vaccine hesitancy were developed to capture its nature and scope at the national and subnational level to collect data in 2014: 1) The top 3 reasons for not accepting vaccines according to the national schedule in the past year and whether the response was opinion- or assessment-based and 2) Whether an assessment (or measurement) of the level of confidence in vaccination had taken place at national or subnational level in the previous 5 years...
2017: PloS One
https://www.readbyqxmd.com/read/28246143/parents-views-of-including-young-boys-in-the-swedish-national-school-based-hpv-vaccination-programme-a-qualitative-study
#11
Maria Gottvall, Christina Stenhammar, Maria Grandahl
OBJECTIVE: To explore parents' views of extending the human papillomavirus (HPV) vaccination programme to also include boys. DESIGN: Explorative qualitative design using individual, face-to-face, interviews and inductive thematic analysis. SETTING: 11 strategically chosen municipalities in central Sweden. PARTICIPANTS: Parents (n=42) who were offered HPV vaccination for their 11-12 years old daughter in the national school-based vaccination programme...
February 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/28245825/predictors-of-correct-technique-in-patients-using-pressurized-metered-dose-inhalers
#12
Kyra Bartolo, Martin Balzan, Emma Louise Schembri, Rachelle Asciak, Darlene Mercieca Balbi, Michael Pace Bardon, Stephen Montefort
BACKGROUND: Corret inhaler technique is recommended by guidelines for optimum asthma care. The objective of the study is to determine real life predictors of correct pressurized metered dose inhaler (pMDI) technique in Asthma and COPD patients. METHODS: Two hundred eight adult patients aged 18+ from respiratory outpatients (69.2%) and the community on regular pMDI for a diagnosis of Asthma (78.9%) or COPD, were recruited. A questionnaire containing 31 possible predictors was administered and pMDI technique with or without spacer was observed by trained researchers on 12 point steps, of which 4 were considered critical...
February 28, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28242152/-post-licensure-safety-surveillance-for-prevenar-13-%C3%A2-in-france
#13
M-S Agier, S Marchand, N Paret, S Gautier, A-P Jonville-Béra
OBJECTIVE: To describe the profile and the incidence of adverse events (AEs) reported with Prevenar 13(®) since its commercialization. METHOD: Analysis of all adverse events reported with Prevenar 13(®) in France between 1st July 2010 and 31 October 2014. RESULTS: In 4 years and 4 months, 376 AEs, including 252 severe (67%), were recorded, 83 of which occurred following an injection of Prevenar 13(®) alone: 39 cutaneous AEs, 16 neurological AEs, four cases of collapse or shock, nine cases of fever, and one of thrombocytopenia...
February 24, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28237943/kinome-profiling-identifies-druggable-targets-for-novel-hcmv-antivirals
#14
Kyle C Arend, Erik M Lenarcic, Heather A Vincent, Naim Rashid, Eric Lazear, Ian M McDonald, Thomas S K Gilbert, Michael P East, Laura E Herring, Gary L Johnson, Lee Graves, Nathaniel J Moorman
Human cytomegalovirus (HCMV) is a significant cause of disease in immunecompromised adults and immune naive newborns. No vaccine exists to prevent HCMV infection, and current antiviral therapies have toxic side effects that limit the duration and intensity of their use. There is thus an urgent need for new strategies to treat HCMV infection. Repurposing existing drugs as antivirals is an attractive approach to limit the time and cost of new antiviral drug development. Virus-induced changes in infected cells are often driven by changes in cellular kinase activity, which led us to hypothesize that defining the complement of kinases (the kinome), whose abundance or expression is altered during infection would identify existing kinase inhibitors that could be repurposed as new antivirals...
February 25, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28237636/vaccine-education-of-medical-students-a-nationwide-cross-sectional-survey
#15
Solen Kernéis, Caroline Jacquet, Aurélie Bannay, Thierry May, Odile Launay, Pierre Verger, Céline Pulcini, Pierre Abgueguen, Séverine Ansart, Firouzé Bani-Sadr, Aurélie Bannay, Louis Bernard, Elisabeth Botelho-Nevers, David Boutoille, Nadim Cassir, Charles Cazanave, Elisa Demonchy, Olivier Epaulard, Manuel Etienne, Emmanuel Faure, Caroline Jacquet, Odile Launay, Vincent Le Moing, Xavier Lescure, Zoha Maakaroun-Vermesse, Guillaume Martin-Blondel, Thierry May, Frédéric Méchai, Guillaume Mellon, Marie-Caroline Meyohas, Lionel Piroth, Céline Pulcini, France Roblot, Jean-Luc Schmit, Albert Sotto, Pierre Tattevin, Renaud Verdon, Pierre Verger, Benjamin Wyplosz
Physicians play a primary role in vaccination of the population. Strong initial training of medical students is therefore essential to enable them to fulfill this role. This cross-sectional nationwide online survey conducted between September 2015 and January 2016 obtained 2,118 completed surveys from 6,690 eligible respondents (response rate, 32%) at 27 of 32 medical schools in France regarding their education about vaccination. The data were analyzed in April-June 2016. The survey covered their knowledge, attitudes, practices, and perceptions, and assessed their level of perceived preparedness for their future practice as interns...
February 22, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28210633/potential-usefulness-of-streptococcus-pneumoniae-extracellular-membrane-vesicles-as-antibacterial-vaccines
#16
Chi-Won Choi, Edmond Changkyun Park, Sung Ho Yun, Sang-Yeop Lee, Seung Il Kim, Gun-Hwa Kim
The secretion of extracellular membrane vesicles (EMVs) is a common phenomenon that occurs in archaea, bacteria, and mammalian cells. The EMVs of bacteria play important roles in their virulence, biogenesis mechanisms, and host cell interactions. Bacterial EMVs have recently become the focus of attention because of their potential as highly effective vaccines that cause few side effects. Here, we isolated the EMVs of Streptococcus pneumoniae and examined their potential as new vaccine candidates. Although the S...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28202532/cd40-signaling-drives-potent-cellular-immune-responses-in-heterologous-cancer-vaccinations
#17
Supot Nimanong, Dmitrij Ostroumov, Jessica Wingerath, Sarah Knocke, Norman Woller, Engin Guerlevik, Christine Falk, Michael P Manns, Florian Kuehnel, Thomas C Wirth
Antagonistic antibodies targeting co-inhibitory receptors have revolutionized the treatment of cancer by inducing durable immune responses and clinical remissions in patients. In contrast, success of agonistic costimulatory antibodies has thus far been limited due to insufficient induction of adaptive immune responses. Here we describe a novel vaccination method consisting of a primary dendritic cell immunization followed by a composite vaccination including an agonistic CD40 antibody, soluble antigen and a TLR3 agonist, referred to as CoAT...
February 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28196736/influenza-vaccination-in-healthcare-workers-comparison-of-side-effects-and-preferred-route-of-administration-of-intradermal-versus-intramuscular-administration
#18
W J Meijer, A M J Wensing, A A Bos, J C F Kuiphuis, E M M Hagelen, J C Wilschut, M J T de Vries, A Riezebos-Brilman
OBJECTIVE: To explore the nature and severity of side effects and future preference of intradermal versus intramuscular influenza vaccination in healthcare workers. DESIGN: Prospective cohort study. SETTING: Two University Medical Centers in The Netherlands. PARTICIPANTS: Healthcare workers receiving an influenza vaccination. METHODS: Healthcare workers that were vaccinated during the influenza vaccination season of 2012-2013 were approached for participation in a questionnaire study...
February 10, 2017: Vaccine
https://www.readbyqxmd.com/read/28193663/results-from-a-patient-based-health-education-intervention-in-reducing-antibiotic-use-for-acute-upper-respiratory-tract-infections-in-the-private-sector-primary-care-setting-in-singapore
#19
Magdalene Hui Min Lee, Darius Shaw Teng Pan, Joyce Huixin Huang, Mark I-Cheng Chen, Joash Wen Chen Chong, Ee Hui Goh, Lili Jiang, Yee Sin Leo, Tau Hong Lee, Chia Siong Wong, Victor Weng Keong Loh, Fong Seng Lim, Adrian Zhongxian Poh, Tat Yean Tham, Wei Mon Wong, Yue Yu
We investigated the efficacy of patient-targeted education in reducing antibiotic prescriptions for upper respiratory tract infections (URTIs) amongst adults in the private primary care setting in Singapore. Our randomized controlled trial enrolled patients aged 21 years and above presenting at GP (general practitioner) clinics with URTI symptoms for 7 days or less. Intervention arm patients were verbally educated via pamphlets about the aetiology of URTIs, role of antibiotics in treating URTIs, and consequences of inappropriate antibiotic use...
February 13, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28186996/harnessing-rna-sequencing-for-global-unbiased-evaluation-of-two-new-adjuvants-for-dendritic-cell-immunotherapy
#20
Till S M Mathan, Johannes Textor, Annette E Sköld, Inge Reinieren-Beeren, Tom van Oorschot, Mareke Brüning, Carl G Figdor, Sonja I Buschow, Ghaith Bakdash, I Jolanda M de Vries
Effective stimulation of immune cells is crucial for the success of cancer immunotherapies. Current approaches to evaluate the efficiency of stimuli are mainly defined by known flow cytometry-based cell activation or cell maturation markers. This method however does not give a complete overview of the achieved activation state and may leave important side effects unnoticed. Here, we used an unbiased RNA sequencing (RNA-seq)-based approach to compare the capacity of four clinical-grade dendritic cell (DC) activation stimuli used to prepare DC-vaccines composed of various types of DC subsets; the already clinically applied GM-CSF and Frühsommer meningoencephalitis (FSME) prophylactic vaccine and the novel clinical grade adjuvants protamine-RNA complexes (pRNA) and CpG-P...
February 8, 2017: Oncotarget
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