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Vaccine AND side effects

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https://www.readbyqxmd.com/read/28548686/studies-on-the-antibody-response-and-side-effects-after-intramuscular-and-intraperitoneal-injection-of-atlantic-lumpfish-cyclopterus-lumpus-l-with-different-oil-based-vaccines
#1
T Erkinharju, M R Lundberg, E Isdal, I Hordvik, R A Dalmo, T Seternes
Atlantic lumpfish (Cyclopterus lumpus L.) is used as a biological delousing agent for sea lice (Lepeophtheirus salmonis K.) infestations in Norwegian aquaculture. Here, we present a study on the antibody response and vaccine side effects after intramuscular and intraperitoneal injection of lumpfish with two vaccines. Both vaccines contained bacterial antigens from atypical Aeromonas salmonicida A-layer types V and VI, Vibrio anguillarum serotype O1 and Moritella viscosa sp., but one vaccine contained a vegetable oil-based adjuvant, while the other contained a mineral oil-based adjuvant...
May 26, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28545902/uptake-of-influenza-vaccination-awareness-and-its-associated-barriers-among-medical-students-of-a-university-hospital-in-central-saudi-arabia
#2
Mohammed S Abalkhail, Mohannad S Alzahrany, Khaled A Alghamdi, Muath A Alsoliman, Mosa A Alzahrani, Badr S Almosned, Ibrahim M Gosadi, Shabana Tharkar
Outbreaks of influenza epidemics are common but influenza vaccination is sub-optimal among the healthcare staff including the medical students. The study aims to assess the rate of vaccine uptake among medical students, its associated barriers and levels of awareness. A cross sectional study was done at a University Hospital in Saudi Arabia on 421 medical students by self administered questionnaire from February to March 2015. The immunization rate of seasonal influenza vaccine was just 20.7% in 2015, while it was 57% for cumulative of previous three-year period...
May 22, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28526972/patient-experiences-attitudes-and-expectations-towards-receiving-information-about-anti-tnf-medication-a-quantitative-study
#3
Jon Packham, Paul Arkell, Tom Sheeran, Ann Brownfield, Anthony Cadwgan, Sarah Ryan
The objective of the study was to measure patient attitudes and experience of information received during drug counselling for rheumatoid arthritis (RA) medications. This is a cross-sectional UK postal questionnaire study. Three RA patient groups-disease-modifying antirheumatic drugs (DMARDs) only, first anti-tumour necrosis factor (anti-TNF) and failed anti-TNF-were sent postal questionnaires. Data on patient history/demographics, drug counselling experience, knowledge of drug side effects, attitudes to vaccinations, cancer screening and blood borne virus testing was collected; 264/679 (39%) patients responded (median age 65 years, 66% female, median disease duration 15 years)...
May 19, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28526059/severe-polyserositis-induced-by-the-13-valent-pneumococcal-conjugate-vaccine-a-case-report
#4
Pierre Tawfik, Elie Gertner, Charlene E McEvoy
BACKGROUND: The United States Advisory Committee on Immunization Practices recommends administration of the 13-valent pneumococcal conjugate vaccine in series with the 23-valent pneumococcal polysaccharide vaccine for prevention of pneumonia in the elderly. Reports of autoimmune or auto-inflammatory diseases as a result of pneumococcal vaccination, especially pneumococcal conjugate vaccine, are extremely rare. CASE PRESENTATION: We present a case of severe serositis in a 75-year-old Caucasian woman complicated by pericardial and pleural effusions in the setting of recent 13-valent pneumococcal conjugate vaccine vaccination and no other obvious etiology...
May 20, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28516208/safety-and-efficiency-of-active-immunization-with-detoxified-antigen-against-scorpion-venom-side-effect-evaluation
#5
Nassrine Bachsais, Lila Boussag-Abib, Fatima Laraba-Djebari
OBJECTIVE: The efficiency and safety of vaccine are the most important properties, however, as any medication, it can induce side effects. This prophylactic therapy could be used to prevent the lethal and pathophysiological effects induced after scorpion envenomation. METHODS: In this study, detoxified venom associated to alum adjuvant (V*alum) is used as a vaccine against scorpion venom for immunization of mice. We evaluate the safety and the inflammatory response of this vaccine...
May 17, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28507496/safety-and-efficacy-of-venom-immunotherapy-a-real-life-study
#6
Agnieszka Kołaczek, Dawid Skorupa, Monika Antczak-Marczak, Piotr Kuna, Maciej Kupczyk
INTRODUCTION: Venom immunotherapy (VIT) is recommended as the first-line treatment for patients allergic to Hymenoptera venom. AIM: To analyze the safety and efficacy of VIT in a real life setting. MATERIAL AND METHODS: One hundred and eighty patients undergoing VIT were studied to evaluate the safety, efficacy, incidence and nature of symptoms after field stings and adverse reactions to VIT. RESULTS: Significantly more patients were allergic to wasp than bee venom (146 vs...
April 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28490039/the-implications-of-immunization-in-the-daily-practice-of-pediatric-anesthesia
#7
Gianluca Bertolizio, Marinella Astuto, Pablo Ingelmo
PURPOSE OF REVIEW: Vaccination is an important prevention measure, but requires an intact immune system. Surgery and anesthesia suppress the immune system and may interfere with the benefits of immunization. Moreover, common vaccine side-effects may be misinterpreted as postsurgical complications. This review summarizes the essential basis of immunization and its potential interactions with anesthesia. RECENT FINDINGS: Vaccines have mild side-effects, such as fever, but may lead to serious complications in immunocompromised patients...
June 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28480274/comparison-of-side-effects-of-the-2015-2016-high-dose-inactivated-trivalent-influenza-vaccine-and-standard-dose-inactivated-trivalent-influenza-vaccine-in-adults-%C3%A2-65-years
#8
Anjum S Kaka, Gregory A Filice, Sharon Myllenbeck, Kristin L Nichol
BACKGROUND: High-dose, inactivated, trivalent influenza vaccine (HD) is associated with higher rates of side effects than standard dose (SD) vaccine, which may represent a barrier to use. METHODS: We surveyed subjects ≥65 years who received either HD or SD vaccine at the Minneapolis Veteran Affairs Health Care System clinics on October 27, 28, or 29, 2015. Research assistants conducted a 17-item telephone survey of influenza vaccine recipients to inquire about self-reported health and symptoms experienced the week after vaccination...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28472641/recombinant-allergy-vaccines-based-on-allergen-derived-b-cell-epitopes
#9
REVIEW
Rudolf Valenta, Raffaela Campana, Verena Niederberger
Immunoglobulin E (IgE)-associated allergy is the most common immunologically-mediated hypersensitivity disease. It affects more than 25% of the population. In IgE-sensitized subjects, allergen encounter can causes a variety of symptoms ranging from hayfever (allergic rhinoconjunctivitis) to asthma, skin inflammation, food allergy and severe life-threatening anaphylactic shock. Allergen-specific immunotherapy (AIT) is based on vaccination with the disease-causing allergens. AIT is an extremely effective, causative and disease-modifying treatment...
May 1, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28471617/causality-assessment-of-serious-neurologic-adverse-events-following-bopv-national-vaccination-campaign-in-israel
#10
Diana Tasher, Eran Kopel, Emilia Anis, Zachi Grossman, Eli Somekh
BACKGROUND: During 2013-2014 Israel experienced a continuous circulation of wild poliovirus type 1 (WPV1) but with no clinical cases. WPV1 circulation was gradually terminated following a national vaccination campaign of bivalent oral poliovirus vaccine (bOPV) for 943,587 children < 10 years. Four cases of children with neurological manifestations that appeared following bOPV vaccinations were reported during the campaign: three of Guillain-Barré syndrome (GBS) and one of acute disseminated encephalomyelitis (ADEM)...
October 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28468973/il-1r-type-1-deficient-mice-demonstrate-an-impaired-host-immune-response-against-cutaneous-vaccinia-virus-infection
#11
Tian Tian, Michelle Qiushuang Jin, Krista Dubin, Sandra L King, Wolfram Hoetzenecker, George F Murphy, Chen Amy Chen, Thomas S Kupper, Robert C Fuhlbrigge
The IL-1 superfamily of cytokines and receptors has been studied extensively. However, the specific roles of IL-1 elements in host immunity to cutaneous viral infection remain elusive. In this study, we applied vaccinia virus (VACV) by scarification to IL-1R1 knockout mice (IL-1R1(-/-)) and found that these mice developed markedly larger lesions with higher viral genome copies in skin than did wild-type mice. The phenotype of infected IL-1R1(-/-) mice was similar to eczema vaccinatum, a severe side effect of VACV vaccination that may develop in humans with atopic dermatitis...
May 3, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28465096/immunological-considerations-regarding-parental-concerns-on-pediatric-immunizations
#12
REVIEW
Francesco Nicoli, Victor Appay
Despite the fundamental role of vaccines in the decline of infant mortality, parents may decide to decline vaccination for their own children. Many factors may influence this decision, such as the belief that the infant immune system is weakened by vaccines, and concerns have been raised about the number of vaccines and the early age at which they are administered. Studies focused on the infant immune system and its reaction to immunizations, summarized in this review, show that vaccines can overcome those suboptimal features of infant immune system that render them more at risk of infections and of their severe manifestations...
April 29, 2017: Vaccine
https://www.readbyqxmd.com/read/28464951/hepatitis-c-virus-management-potential-impact-of-nanotechnology
#13
REVIEW
Mostafa H Elberry, Noureldien H E Darwish, Shaker A Mousa
Around 170-200 million individuals have hepatitis C virus (HCV), which represents ~ 3% of the world population, including ~ 3-5 million people in the USA. According to the WHO regional office in the Middle East, Egypt has the highest prevalence in the world, with 7% prevalence in adults. There had been no effective vaccine for HCV; a combination of PEG-Interferon and ribavirin for at least 48 weeks was the standard therapy, but it failed in more than 40% of the patients and has a high cost and serious side effects...
May 2, 2017: Virology Journal
https://www.readbyqxmd.com/read/28457885/genome-engineering-of-stem-cells-for-autonomously-regulated-closed-loop-delivery-of-biologic-drugs
#14
Jonathan M Brunger, Ananya Zutshi, Vincent P Willard, Charles A Gersbach, Farshid Guilak
Chronic inflammatory diseases such as arthritis are characterized by dysregulated responses to pro-inflammatory cytokines such as interleukin-1 (IL-1) and tumor necrosis factor α (TNF-α). Pharmacologic anti-cytokine therapies are often effective at diminishing this inflammatory response but have significant side effects and are used at high, constant doses that do not reflect the dynamic nature of disease activity. Using the CRISPR/Cas9 genome-engineering system, we created stem cells that antagonize IL-1- or TNF-α-mediated inflammation in an autoregulated, feedback-controlled manner...
May 9, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28454674/immunogenicity-and-safety-of-three-aluminium-hydroxide-adjuvanted-vaccines-with-reduced-doses-of-inactivated-polio-vaccine-ipv-al-compared-with-standard-ipv-in-young-infants-in-the-dominican-republic-a-phase-2-non-inferiority-observer-blinded-randomised-and
#15
Luis Rivera, Rasmus S Pedersen, Lourdes Peña, Klaus J Olsen, Lars V Andreasen, Ingrid Kromann, Pernille I Nielsen, Charlotte Sørensen, Jes Dietrich, Ananda S Bandyopadhyay, Birgit Thierry-Carstensen
BACKGROUND: Cost and supply constraints are key challenges in the use of inactivated polio vaccine (IPV). Dose reduction through adsorption to aluminium hydroxide (Al) is a promising option, and establishing its effectiveness in the target population is a crucial milestone in developing IPV-Al. The aim of this clinical trial was to show the non-inferiority of three IPV-Al vaccines to standard IPV. METHODS: In this phase 2, non-inferiority, observer-blinded, randomised, controlled, single-centre trial in the Dominican Republic, healthy infants aged 6 weeks, not previously polio vaccinated, were allocated after computer-generated randomisation by block-size of four, to receive one of four IPV formulations (three-times reduced dose [1/3 IPV-Al], five-times reduced dose [1/5 IPV-Al], ten-times reduced dose [1/10 IPV-Al], or IPV) intramuscularly in the thigh at 6, 10, and 14 weeks of age...
April 25, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28450651/the-immunogenicity-and-safety-of-cyd-tetravalent-dengue-vaccine-cyd-tdv-in-children-and-adolescents-a-systematic-review
#16
Raksheeth Agarwal, Mardiastuti H Wahid, Oliver E Yausep, Sharon H Angel, Angga W Lokeswara
AIM: to assess the immunogenicity and safety of CYD-tetravalent dengue vaccine (CYD-TDV) in children. METHODS: comprehensive literature searches were conducted on various databases. Randomized-controlled trials on children with CYD-TDV as intervention were selected based on inclusion and exclusion criteria. Data extracted from selected trials included safety of vaccine and immunogenicity in terms of Geometric Mean Titres (GMT) of antibodies. RESULTS:   six clinical trials were selected based on preset criteria...
January 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28449918/better-knowledge-and-regular-vaccination-practices-correlate-well-with-higher-seasonal-influenza-vaccine-uptake-in-people-at-risk-promising-survey-results-from-a-university-outpatient-clinic
#17
Işıl Adadan Güvenç, Hülya Parıldar, Mustafa Kürşat Şahin, Selim Sermed Erbek
BACKGROUND: The knowledge, beliefs, opinions, and attitudes of patients and their relatives regarding seasonal influenza vaccination were evaluated. METHODS: This descriptive study was undertaken in the outpatient clinics of Baskent University Hospital. There were 566 responders who completed a self-administered questionnaire. RESULTS: The mean age of participants was 48.35 years, and 16.8% were ≥65 years. Of the responders, 21.7% were vaccinated this year, whereas 57...
April 24, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28434403/immunotherapy-in-genitourinary-malignancies
#18
REVIEW
Kathan Mehta, Keyur Patel, Rahul A Parikh
Treatment of cancer patients involves a multidisciplinary approach including surgery, radiotherapy, and chemotherapy. Traditionally, patients with metastatic disease are treated with combination chemotherapies or targeted agents. These cytotoxic agents have good response rates and achieve palliation; however, complete responses are rarely seen. The field of cancer immunology has made rapid advances in the past 20 years. Recently, a number of agents and vaccines, which modulate the immune system to allow it to detect and target cancer cells, are being developed...
April 24, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28433563/aryl-thiosemicarbazones-in%C3%A2-vitro-and-immunomodulatory-activities-against-l-%C3%A2-amazonensis
#19
Aline Caroline da Silva, Thiago André Ramos Dos Santos, Isis Viviane Bezerra da Silva, Marcos Victor Gregório de Oliveira, Diogo Rodrigo Magalhães Moreira, Ana Cristina Lima Leite, Valéria Rêgo Alves Pereira
Leishmaniasis is an infection caused by different species of Leishmania genus. Currently, there is no vaccine available for Leishmania infections in humans and conventional treatments are limited due to side effects. Therefore, the development of new antileishmanial drugs is an urgent need. In present study, we evaluated the cytotoxicity in host cells, leishmanicidal activity and immunomodulatory potential of seven aryl thiosemicarbazones. Host cell cytotoxicity was determined in peritoneal macrophages of BALB/c mouse, antiparasitic activity was determined against promastigotes and amastigotes of WHOM/00LTB 0016 strain of L...
April 19, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28425901/a-systematic-review-and-meta-analysis-for-the-adverse-effects-immunogenicity-and-efficacy-of-lyme-disease-vaccines-guiding-novel-vaccine-development
#20
Alaa Badawi, Maria Shering, Shusmita Rahman, L Robbin Lindsay
BACKGROUND: Lyme borreliosis (LB) is the most prevalent arthropod-borne infectious disease in North America. Currently, no vaccine is available to prevent LB in humans, although monovalent and multivalent vaccines have been developed in the past. OBJECTIVE: The aim of the current study is to conduct a systematic review and meta-analysis to evaluate and compare the findings from these two classes of vaccines for their reactogenicity, immunogenicity and efficacy, in the hope this may assist in the development of future vaccines...
April 20, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
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