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Vaccine AND side effects

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https://www.readbyqxmd.com/read/28425901/a-systematic-review-and-meta-analysis-for-the-adverse-effects-immunogenicity-and-efficacy-of-lyme-disease-vaccines-guiding-novel-vaccine-development
#1
Alaa Badawi, Maria Shering, Shusmita Rahman, L Robbin Lindsay
BACKGROUND: Lyme borreliosis (LB) is the most prevalent arthropod-borne infectious disease in North America. Currently, no vaccine is available to prevent LB in humans, although monovalent and multivalent vaccines have been developed in the past. OBJECTIVE: The aim of the current study is to conduct a systematic review and meta-analysis to evaluate and compare the findings from these two classes of vaccines for their reactogenicity, immunogenicity and efficacy, in the hope this may assist in the development of future vaccines...
April 20, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28410814/the-effects-of-convenience-and-quality-on-the-demand-for-vaccination-results-from-a-discrete-choice-experiment
#2
Na Guo, Guojie Zhang, Dawei Zhu, Jian Wang, Luwen Shi
BACKGROUND: Vaccination is an effective way to prevent infectious diseases. Most studies analysed people's vaccine decisions, but few studies have analysed the effects of convenience such as immunisation schedule and distance and the quality of vaccination service on vaccination uptake. OBJECTIVE: The aim of this paper was to investigate adults' preferences for convenience and quality of vaccination service, calculate the private economic benefit from convenience (vaccination schedule and distance) and quality, and predict the uptake rate for different vaccine scenarios...
April 12, 2017: Vaccine
https://www.readbyqxmd.com/read/28408120/quantifying-population-preferences-around-vaccination-against-severe-but-rare-diseases-a-conjoint-analysis-among-french-university-students-2016
#3
Joy Seanehia, Carole Treibich, Christine Holmberg, Jacqueline Müller-Nordhorn, Valerie Casin, Jocelyn Raude, Judith E Mueller
BACKGROUND: Several concepts are available to explain vaccine decision making by individual and inter-individual factors, including risk perception, social conformism and altruism. However, only a few studies have quantified the weight of these determinants in vaccine acceptance. Using a conjoint analysis tool, we aimed at eliciting preferences in a student population regarding vaccination against a rare, severe and rapidly evolving hypothetical disease, similar to meningococcal serogroup C meningitis or measles...
April 10, 2017: Vaccine
https://www.readbyqxmd.com/read/28390901/bcg-vaccine-powder-laden-and-dissolvable-microneedle-arrays-for-lesion-free-vaccination
#4
Fan Chen, Qinying Yan, Yang Yu, Mei X Wu
Live attenuated Bacille Calmette-Guerin (BCG) bacillus is the only licensed vaccine for tuberculosis prevention worldwide to date. It must be delivered intradermally to be effective, which causes severe skin inflammation and sometimes, permanent scars. To minimize the side effects, we developed a novel microneedle array (MNA) that could deliver live attenuated freeze-dried BCG powder into the epidermis in a painless, lesion-free, and self-applicable fashion. The MNA was fabricated with biocompatible and dissolvable hyaluronic acid with a deep cave formed in the basal portion of each microneedle, into which BCG powder could be packaged directly...
April 5, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28377769/antibody-dependent-cell-mediated-cytotoxicity-epitopes-on-the-hemagglutinin-head-region-of-pandemic-h1n1-influenza-virus-play-detrimental-roles-in-h1n1-infected-mice
#5
Zi-Wei Ye, Shuofeng Yuan, Kwok-Man Poon, Lei Wen, Dong Yang, Zehua Sun, Cun Li, Meng Hu, Huiping Shuai, Jie Zhou, Mei-Yun Zhang, Bo-Jian Zheng, Hin Chu, Kwok-Yung Yuen
Engaging the antibody-dependent cell-mediated cytotoxicity (ADCC) for killing of virus-infected cells and secretion of antiviral cytokines and chemokines was incorporated as one of the important features in the design of universal influenza vaccines. However, investigation of the ADCC epitopes on the highly immunogenic influenza hemagglutinin (HA) head region has been rarely reported. In this study, we determined the ADCC and antiviral activities of two putative ADCC epitopes, designated E1 and E2, on the HA head of a pandemic H1N1 influenza virus in vitro and in a lethal mouse model...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28376806/improving-immunization-in-afghanistan-results-from-a-cross-sectional-community-based-survey-to-assess-routine-immunization-coverage
#6
Raveesha R Mugali, Farooq Mansoor, Sardar Parwiz, Fazil Ahmad, Najibullah Safi, Ariel Higgins-Steele, Sherin Varkey
BACKGROUND: Despite progress in recent years, Afghanistan is lagging behind in realizing the full potential of immunization. The country is still endemic for polio transmission and measles outbreaks continue to occur. In spite of significant reductions over the past decade, the mortality rate of children under 5 years of age continues to remain high at 91 per 1000 live births. METHODS: The study was a descriptive community-based cross sectional household survey...
April 4, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28366139/-attitudes-of-adult-asthma-patients-towards-influenza-vaccination
#7
Zeynep Çelebi Sözener, Mehmet Mısırlıgil, Pamir Çerçi, Ömür Aydın, Reşat Kendirlinan, Betül Sin, Zeynep Mısırlıgil
Introduction: It is known that viral infections trigger exacerbations in asthma patients.There are conflicting reports on whether influenza vaccine is preventive or not. In this study, we aimed to evaluate asthmatic patient's attitude towards influenza vaccine and to determine which factors affect this attitude. Materials and Methods: A questionnaire involving data about demographic information, co-morbidities, frequency of viral upper respiratory tract infections, subject's influenza vaccination status and attitude towards vaccination had been filled for our outpatient clinic asthma patients and also for healthy controls...
December 2016: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/28352933/erythema-multiforme-following-pneumococcal-vaccination
#8
Alexandra Monastirli, Efstathia Pasmatzi, George Badavanis, Dionysios Tsambaos
Erythema multiforme (EM) is an acute and usually self-limited immune-mediated mucocutaneous disorder that is a hypersensitivity reaction to drugs, infections, and vaccines. Clinically, it is characterized by maculopapular, target-like lesions symmetrically distributed on the extremities (minor form) or additionally affecting one or more mucous membranes and causing epidermal detachment involving < 10% of the total body surface area (major form). We report a novel association between pneumococcal vaccination and the development of EM in a 2...
March 2017: Acta Dermatovenerologica Alpina, Panonica, et Adriatica
https://www.readbyqxmd.com/read/28337203/a-universal-vaccine-against-leptospirosis-are-we-going-in-the-right-direction
#9
André Alex Grassmann, Jéssica Dias Souza, Alan John Alexander McBride
Leptospirosis is the most widespread zoonosis in the world and a neglected tropical disease estimated to cause severe infection in more than one million people worldwide every year that can be combated by effective immunization. However, no significant progress has been made on the leptospirosis vaccine since the advent of bacterins over 100 years. Although protective against lethal infection, particularly in animals, bacterin-induced immunity is considered short term, serovar restricted, and the vaccine can cause serious side effects...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28324748/influenza-vaccination-in-adult-patients-with-solid-tumours-treated-with-chemotherapy
#10
REVIEW
Albert Vollaard, Imke Schreuder, Lizzy Slok-Raijmakers, Wim Opstelten, Guus Rimmelzwaan, Hans Gelderblom
Patients with solid tumours receiving chemotherapy are at risk for influenza complications. Yearly influenza vaccination is recommended to patients treated with chemotherapy. However, adherence to vaccination is low, most likely due to lack of data on efficacy, optimal timing and safety of vaccination. There is scarce evidence for the effectiveness of the influenza vaccine in adult patients with solid tumours and chemotherapy on reduction of pneumonia, decreased mortality and fewer interruptions of oncological treatment...
May 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28317886/systems-pharmacology-based-strategy-to-screen-new-adjuvant-for-hepatitis-b-vaccine-from-traditional-chinese-medicine-ophiocordyceps-sinensis
#11
Jingbo Wang, Rui Liu, Baoxiu Liu, Yan Yang, Jun Xie, Naishuo Zhu
Adjuvants are common component for many vaccines but there are still few licensed for human use due to low efficiency or side effects. The present work adopted Systems Pharmacology analysis as a new strategy to screen adjuvants from traditional Chinese medicine. Ophiocordyceps sinensis has been used for many years in China and other Asian countries with many biological properties, but the pharmacological mechanism has not been fully elucidated. First in this study, 190 putative targets for 17 active compounds in Ophiocordyceps sinensis were retrieved and a systems pharmacology-based approach was applied to provide new insights into the pharmacological actions of the drug...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28314047/the-role-of-risk-perception-in-flu-vaccine-behavior-among-african-american-and-white-adults-in-the-united-states
#12
Vicki S Freimuth, Amelia Jamison, Gregory Hancock, Donald Musa, Karen Hilyard, Sandra Crouse Quinn
Seasonal flu vaccination rates are low for U.S. adults, with significant disparities between African and white Americans. Risk perception is a significant predictor of vaccine behavior but the research on this construct has been flawed. This study addressed critical research questions to understand the differences between African and white Americans in the role of risk perception in flu vaccine behavior: (1) What is the dimensionality of risk perception and does it differ between the two races?  (2) Were risk perceptions of white and African-American populations different and how were sociodemographic characteristics related to risk for each group? (3) What is the relation between risk perception and flu vaccine behaviors for African Americans and whites? The sample, drawn from GfK's Knowledge Panel, consisted of 838 whites and 819 African Americans...
March 17, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28304339/the-five-immune-forces-impacting-dna-based-cancer-immunotherapeutic-strategy
#13
REVIEW
Suneetha Amara, Venkataswarup Tiriveedhi
DNA-based vaccine strategy is increasingly realized as a viable cancer treatment approach. Strategies to enhance immunogenicity utilizing tumor associated antigens have been investigated in several pre-clinical and clinical studies. The promising outcomes of these studies have suggested that DNA-based vaccines induce potent T-cell effector responses and at the same time cause only minimal side-effects to cancer patients. However, the immune evasive tumor microenvironment is still an important hindrance to a long-term vaccine success...
March 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28302411/immunogenicity-and-safety-of-a-quadrivalent-inactivated-influenza-vaccine-compared-with-two-trivalent-inactivated-influenza-vaccines-containing-alternate-b-strains-in-adults-a-phase-3-randomized-noninferiority-study
#14
John T Treanor, Frank R Albano, Daphne C Sawlwin, Alison Graves Jones, Jolanta Airey, Neil Formica, Vince Matassa, Jane Leong
BACKGROUND: Vaccination is the most effective means of influenza prevention. Efficacy of trivalent vaccines may be enhanced by including both B strain lineages. This phase 3, double-blind study assessed the immunogenicity and safety/tolerability of a quadrivalent inactivated influenza vaccine (IIV4) versus the United States (US)-licensed 2014-2015 trivalent inactivated influenza vaccine (IIV3-Yamagata [IIV3-YAM]; Afluria) and IIV3 containing the alternate Victoria B strain (IIV3-VIC) in adults ≥18years...
March 13, 2017: Vaccine
https://www.readbyqxmd.com/read/28301479/ligb-subunit-vaccine-confers-sterile-immunity-against-challenge-in-the-hamster-model-of-leptospirosis
#15
Neida L Conrad, Flávia W Cruz McBride, Jéssica D Souza, Marcelle M Silveira, Samuel Félix, Karla S Mendonça, Cleiton S Santos, Daniel A Athanazio, Marco A Medeiros, Mitermayer G Reis, Odir A Dellagostin, Alan J A McBride
Neglected tropical diseases, including zoonoses such as leptospirosis, have a major impact on rural and poor urban communities, particularly in developing countries. This has led to major investment in antipoverty vaccines that focus on diseases that influence public health and thereby productivity. While the true, global, impact of leptospirosis is unknown due to the lack of adequate laboratory diagnosis, the WHO estimates that incidence has doubled over the last 15 years to over 1 million cases that require hospitalization every year...
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28293422/regional-disparities-in-immunization-services-in-ghana-through-a-bottleneck-analysis-approach-implications-for-sustaining-national-gains-in-immunization
#16
A E Yawson, G Bonsu, L K Senaya, A O Yawson, J B Eleeza, J K Awoonor-Williams, H K Banskota, E E A Agongo
BACKGROUND: Immunization is considered one of the most cost effective public health interventions for reducing child morbidity, mortality and disability. The aim of this work is to describe the application of the Bottleneck analysis (BNA) process to assess gaps in immunization services in Ghana and implications for sustaining the gains in Immunization coverage. METHODS: A national assessment was conducted in May 2015, through use of desk reviews, field visits and key informant interviews...
2017: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/28291647/health-professional-feedback-on-hpv-vaccination-roll-out-in-a-developing-country
#17
Collette Venturas, Kanayo Umeh
BACKGROUND: Worldwide, Zambia has the highest cervical cancer incidence rates (58.4/100,000 per year) and mortality rates (36.2/100,000 per year). The human papilloma virus (HPV) vaccine is considered a vital preventative measure against cervical cancer, particularly in sub-Saharan countries, such as Zambia. Past research suggests health professionals' experiences with HPV vaccination rollout can have practical implications for effective delivery. OBJECTIVE: To explore health professionals' perspectives on the HPV vaccination programme in Zambia...
March 10, 2017: Vaccine
https://www.readbyqxmd.com/read/28284680/psychological-factors-associated-with-uptake-of-the-childhood-influenza-vaccine-and-perception-of-post-vaccination-side-effects-a-cross-sectional-survey-in-england
#18
Louise E Smith, Rebecca K Webster, John Weinman, Richard Amlôt, Jenny Yiend, G James Rubin
OBJECTIVES: To identify predictors of: uptake of the childhood influenza vaccine in the 2015-2016 influenza season, parental perceptions of side-effects from the influenza vaccine and intention to vaccinate one's child for influenza in the 2016-2017 influenza season. DESIGN: Cross-sectional online survey. SETTING: Data were collected in England shortly after the end of the 2015-2016 immunization campaign. PARTICIPANTS: 1001 parents or guardians of children aged between two and seven...
February 24, 2017: Vaccine
https://www.readbyqxmd.com/read/28249006/assessments-of-global-drivers-of-vaccine-hesitancy-in-2014-looking-beyond-safety-concerns
#19
Melanie Marti, Monica de Cola, Noni E MacDonald, Laure Dumolard, Philippe Duclos
Vaccine hesitancy has become the focus of growing attention and concern globally despite overwhelming evidence of the value of vaccines in preventing disease and saving the lives of millions of individuals every year. Measuring vaccine hesitancy and its determinants worldwide is important in order to understand the scope of the problem and for the development of evidence-based targeted strategies to reduce hesitancy. Two indicators to assess vaccine hesitancy were developed to capture its nature and scope at the national and subnational level to collect data in 2014: 1) The top 3 reasons for not accepting vaccines according to the national schedule in the past year and whether the response was opinion- or assessment-based and 2) Whether an assessment (or measurement) of the level of confidence in vaccination had taken place at national or subnational level in the previous 5 years...
2017: PloS One
https://www.readbyqxmd.com/read/28246143/parents-views-of-including-young-boys-in-the-swedish-national-school-based-hpv-vaccination-programme-a-qualitative-study
#20
Maria Gottvall, Christina Stenhammar, Maria Grandahl
OBJECTIVE: To explore parents' views of extending the human papillomavirus (HPV) vaccination programme to also include boys. DESIGN: Explorative qualitative design using individual, face-to-face, interviews and inductive thematic analysis. SETTING: 11 strategically chosen municipalities in central Sweden. PARTICIPANTS: Parents (n=42) who were offered HPV vaccination for their 11-12 years old daughter in the national school-based vaccination programme...
February 28, 2017: BMJ Open
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