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https://www.readbyqxmd.com/read/29468794/multiarm-polyethylene-glycol-polyglutamic-acid-peptide-dendrimer-design-synthesis-and-dissolving-thrombus
#1
Shao-Fei Zhang, Shaoyu Lü, Chunmei Gao, Jiandong Yang, Xiang Yan, Tao Li, Na Wen, Mengjie Huang, Mingzhu Liu
Thrombotic events affect many individuals in a number of ways, all of which can cause significant morbidity and mortality. Nattokinase (NK), as a novel thrombolytic drug, has been used for thrombolytic therapy. It not only possesses plasminogen activator activity, but also directly digests fibrin through limited proteolysis. However, it may undergo inactivation and denaturation in the harsh external environment. In this study, a multiarm-polyethylene glycol-polyglutamic acid peptide dendrimer was fabricated and used as a carrier for NK protection and delivery...
February 22, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29468393/growth-performance-metal-accumulation-and-biochemical-responses-of-palak-beta-vulgaris-l-var-allgreen-h-1-grown-on-soil-amended-with-sewage-sludge-fly-ash-mixtures
#2
Bhavisha Sharma, Richa Kothari, Rajeev Pratap Singh
Agricultural utilization of sewage sludge (SS) and fly ash (FA) has become both, a common practice and an alternative disposal method for these wastes all around the world. The present study was conducted to assess the effect and viability of co-application of SS and FA (SLASH) in four mixing ratios denoted as A [4 (SS): 1(FA)], B [4 (SS): 2 (FA)], C [4 (SS): 3 (FA)] and D [4 (SS): 4(FA)] at three application rates viz. 20, 40 and 60% (w/w) with agricultural soil on biochemical, physiological and growth response of Palak (Beta vulgaris L...
February 21, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29467903/effect-of-selective-inhibition-of-aquaporin-1-on-chemotherapy-sensitivity-of-j82-human-bladder-cancer-cells
#3
Xuefeng Zhang, Yun Chen, Liming Dong, Benkang Shi
The occurrence of resistance to mitomycin C (MMC) often limits its clinical effectiveness. Combination therapy thus is employed to overcome this treatment resistance. The present study aimed to establish a novel J82 bladder cancer cell line so as to study the effect of inhibition of aquaporin 1 (AQP-1) on chemotherapy sensitivity of J82 bladder cancer cells. A novel J82 bladder cancer cell line whose expression of AQP-1 is inhibited was established through transfection of J82 cells with newly constructed recombinant plasmid...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29467862/lentivirus-mediated-silencing-of-hotair-lncrna-restores-gefitinib-sensitivity-by-activating-bax-caspase-3-and-suppressing-tgf-%C3%AE-egfr-signaling-in-lung-adenocarcinoma
#4
Yuanshun Liu, Hua Jiang, Hongbin Zhou, Xiwang Ying, Zhehua Wang, Yang Yang, Wulin Xu, Xujun He, Yaqing Li
Secondary resistance is a major limitation in the efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor treatment of lung cancer. Previous studies have shown that expression of the long non-coding RNA HOX transcript antisense RNA (HOTAIR) is upregulated in lung cancer, which is correlated with metastasis and poor prognosis. However, the precise role of HOTAIR and its effects on gefitinib resistance in human lung adenocarcinoma are not known. To address this issue, in the present study we established a gefitinib-resistant (R)PC-9 human lung adenocarcinoma cell line and examined cell viability with the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium assay...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29467014/a-biomaterials-approach-to-influence-stem-cell-fate-in-injectable-cell-based-therapies
#5
Mahetab H Amer, Felicity R A J Rose, Kevin M Shakesheff, Lisa J White
BACKGROUND: Numerous stem cell therapies use injection-based administration to deliver high-density cell preparations. However, cell retention rates as low as 1% have been observed within days of transplantation. This study investigated the effects of varying administration and formulation parameters of injection-based administration on cell dose recovery and differentiation fate choice of human mesenchymal stem cells. METHODS: The impact of ejection rate via clinically relevant Hamilton micro-syringes and biomaterial-assisted delivery was investigated...
February 21, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29463472/interferon-gamma-induces-reversible-metabolic-reprogramming-of-m1-macrophages-to-sustain-cell-viability-and-pro-inflammatory-activity
#6
Feilong Wang, Song Zhang, Ryounghoon Jeon, Ivan Vuckovic, Xintong Jiang, Amir Lerman, Clifford D Folmes, Petras D Dzeja, Joerg Herrmann
Classical activation of M1 macrophages with lipopolysaccharide (LPS) is associated with a metabolic switch from oxidative phosphorylation to glycolysis. However, the generalizability of such metabolic remodeling to other modes of M1 macrophage stimulation, e.g. type II interferons (IFNs) such as IFNγ, has remained unknown as has the functional significance of aerobic glycolysis during macrophage activation. Here we demonstrate that IFNγ induces a rapid activation of aerobic glycolysis followed by a reduction in oxidative phosphorylation in M1 macrophages...
February 13, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29460842/engineering-principles-for-guiding-spheroid-function-in-the-regeneration-of-bone-cartilage-and-skin
#7
Marissa Gionet-Gonzales, Kent Leach
There is a critical need for strategies that effectively enhance cell viability and post-implantation performance in order to advance cell-based therapies. Spheroids, which are dense cellular aggregates, overcome many current limitations with transplanting individual cells. Compared to individual cells, the aggregation of cells into spheroids results in increased cell viability, together with enhanced proangiogenic, anti-inflammatory, and tissue-forming potential. Furthermore, the transplantation of cells using engineered materials enables localized delivery to the target site while providing an opportunity to guide cell fate in situ, resulting in improved therapeutic outcomes compared to systemic or localized injection...
February 20, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/29460046/multiparametric-us-for-scrotal-diseases
#8
Michele Bertolotto, Matilda Muça, Francesca Currò, Stefano Bucci, Laurence Rocher, Maria Assunta Cova
Multiparametric US is increasingly recognized as a valuable problem-solving technique in scrotal pathologies. Compared to conventional Doppler modes, contrast-enhanced ultrasonography (CEUS) has higher sensitivity in assessing the presence or absence of flows, and to improve differentiation between poorly vascularized tumors and non-neoplastic, avascular lesions. Characterization of benign and malignant complex cysts is improved. In trauma patients, CEUS can help evaluating the viability of testicular parenchyma...
February 19, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29459236/toward-rapid-analysis-forecast-and-discovery-of-bioactive-compounds-from-herbs-by-jointly-using-thin-layer-chromatography-and-ratiometric-surface-enhanced-raman-spectroscopy-technique
#9
Xiaoling Gu, Yang Jin, Fang Dong, Yueqing Cai, Zhengyi You, Junhui You, Liying Zhang, Shuhu Du
Conventional isolation and identification of active compounds from herbs have been extensively reported by using various chromatographic and spectroscopic techniques. However, how to quickly discover new bioactive ingredients from natural sources still remains a challenging task due to the interference of their similar structures or matrices. Here, we present a grand approach for rapid analysis, forecast and discovery of bioactive compounds from herbs based on a hyphenated strategy of thin layer chromatography and ratiometric surface-enhanced Raman spectroscopy...
February 11, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29459203/comprehensive-evaluation-on-effective-leaching-of-critical-metals-from-spent-lithium-ion-batteries
#10
Wenfang Gao, Chenming Liu, Hongbin Cao, Xiaohong Zheng, Xiao Lin, Haijuan Wang, Yi Zhang, Zhi Sun
Recovery of metals from spent lithium-ion batteries (LIBs) has attracted worldwide attention because of issues from both environmental impacts and resource supply. Leaching, for instance using an acidic solution, is a critical step for effective recovery of metals from spent LIBs. To achieve both high leaching efficiency and selectivity of the targeted metals, improved understanding on the interactive features of the materials and leaching solutions is highly required. However, such understanding is still limited at least caused by the variation on physiochemical properties of different leaching solutions...
February 16, 2018: Waste Management
https://www.readbyqxmd.com/read/29459128/clinical-viability-of-single-implant-retained-mandibular-overdentures-a-systematic-review-and-meta-analysis
#11
REVIEW
V E de Souza Batista, A J Vechiato-Filho, J F Santiago, M V Sonego, F R Verri, D M Dos Santos, M C Goiato, E P Pellizzer
The aim of this meta-analysis was to verify the clinical viability of single implant-retained mandibular overdentures (SIMO). An electronic search of the PubMed and Cochrane databases was performed (end date July 2017); this was supplemented by a manual search of the literature. Only prospective clinical trials and randomized controlled trials (RCTs) that evaluated SIMO with a minimum follow-up of 12 months were included. The meta-analysis was based on the Mantel-Haenszel method. Dental implant and prosthetic failure were the dichotomous outcome measures; these were evaluated through the risk ratio (RR) and odds ratio (OR), with corresponding 95% confidence intervals (CI)...
February 16, 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29458341/correction-to-preferred-prenatal-counselling-at-the-limits-of-viability-a-survey-among-dutch-perinatal-professionals
#12
Ms Rosa Geurtzen, Arno Van Heijst, Rosella Hermens, Hubertina Scheepers, Mallory Woiski, Jos Draaisma, Marije Hogeveen
Following publication of the original article [1], the corresponding authors wrote to say that there was a mistake in the transfer of her article to PubMed: her name is R Geurtzen, but the pdf-file names her as ms R Geurtzen and pubmed names her as MR Geurtzen.
February 19, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29458042/pretreatment-with-cholesterol-loaded-cyclodextrins-prevents-loss-of-motility-associated-proteins-during-cryopreservation-of-addra-gazelle-nanger-dama-ruficollis-spermatozoa
#13
Jessye Wojtusik, Yan Wang, Budhan S Pukazhenthi
Sperm cryopreservation is challenging, often resulting in irreversible damage to spermatozoa, as indicated by decreased motility, viability, and/or acrosomal integrity. Developing cryopreservation protocols for gametes of endangered species compounds the complexity of technique optimization; samples are difficult to obtain and numbers are limited. Cryopreservation of sperm collected from the critically endangered addra gazelle (Nanger dama ruficollis), a member of the Bovidae family, resulted in significant loss of motility, which was prevented by pretreatment with cholesterol-loaded cyclodextrin (CLC)...
February 16, 2018: Cryobiology
https://www.readbyqxmd.com/read/29455258/effects-of-capsaicin-on-ovarian-granulosa-cell-proliferation-and-apoptosis
#14
Sabire Güler, Berrin Zik
Capsaicin is the pungent ingredient in red peppers. Due to the effects on the sensory nerve fibers, capsaicin has been used to treat pain and inflammation associated with a variety of diseases including rheumatoid arthritis and diabetic neuropathy, obesity, and cardiovascular and gastrointestinal conditions. Despite the extensive publications on different systems, the studies of the effects on the ovary are very limited. The present study was conducted to examine the possible proliferative and/or apoptotic effects of various doses of capsaicin on primarily derived granulosa cells...
February 17, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29454751/strain-dependent-variation-in-acute-ischemic-muscle-injury
#15
Cameron A Schmidt, Adam J Amorese, Terence E Ryan, Emma J Goldberg, Michael D Tarpey, Thomas D Green, Reema R Karnekar, Dean J Yamaguchi, Espen E Spangenburg, Joseph M McClung
Limited efficacy of clinical interventions for peripheral arterial disease (PAD) necessitates a better understanding of the environmental and genetic determinants of tissue pathology. Existing research has largely ignored the early skeletal muscle injury response during hindlimb ischemia (HLI). We compared the hindlimb muscle response, following six hours of ischemia, in two mouse strains that differ dramatically in their post-ischemic extended recovery: C57BL/6J and BALB/cJ. Perfusion, measured by laser Doppler and normalized to the control limb, differed only slightly between strains following HLI (<12% across all measures)...
February 15, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29454628/tunica-vaginalis-flap-for-salvaging-testicular-torsion-a-matched-cohort-analysis
#16
D I Chu, K Gupta, T Kawal, J P Van Batavia, D K Bowen, M R Zaontz, T F Kolon, D A Weiss, S A Zderic, D A Canning
INTRODUCTION: In testicular torsion, ischemia time from pain onset impacts testicular salvage. A tunica albuginea fasciotomy to relieve compartment pressure followed by a tunica vaginalis flap (TVF) may enhance salvage. OBJECTIVE: To define the optimal window of ischemia time during which TVF may be most beneficial to avoid orchiectomy. STUDY DESIGN: A retrospective cohort study of males presenting with testicular torsion at a single tertiary-care institution from January, 2003 to March, 2017...
February 6, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29454513/outcomes-and-related-factors-in-a-cohort-of-infants-born-in-taiwan-over-a-period-of-five-years-2007-2011-with-borderline-viability
#17
Jui-Hsing Chang, Chyong-Hsin Hsu, Kao-Inn Tsou, Wai-Tim Jim
BACKGROUND: Advances in perinatal and neonatal care have increased the survival of extremely preterm infants, but the viability limit is still debated. Here we assess the survival, neonatal morbidity, and neurodevelopmental outcomes at 2 years of age of infants born at 22-26 weeks of gestation in Taiwan between 2007 and 2011. METHODS: This is a prospective longitudinal multicenter cohort study on extremely preterm infants registered in the Taiwan Premature Infant Developmental Collaborative Study Group from 2007 to 2011, including 22 neonatal care centers...
February 14, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29454105/assessing-the-repeatability-of-absolute-cmro-2-oef-and-haemodynamic-measurements-from-calibrated-fmri
#18
Alberto Merola, Michael A Germuska, Kevin Murphy, Richard G Wise
As energy metabolism in the brain is largely oxidative, the measurement of cerebral metabolic rate of oxygen consumption (CMRO 2 ) is a desirable biomarker for quantifying brain activity and tissue viability. Currently, PET techniques based on oxygen isotopes are the gold standard for obtaining whole brain CMRO 2 maps. Among MRI techniques that have been developed as an alternative are dual calibrated fMRI (dcFMRI) methods, which exploit simultaneous measurements of BOLD and ASL signals during a hypercapnic-hyperoxic experiment to modulate brain blood flow and oxygenation...
February 14, 2018: NeuroImage
https://www.readbyqxmd.com/read/29453775/effect-of-pparg-on-ages-induced-akt-mtor-signaling-associated-human-chondrocytes-autophagy
#19
Zhao-Jun Wang, Hai-Bin Zhang, Cheng Chen, Hao Huang, Jian-Xia Liang
Accumulation of advanced glycation end products (AGEs) in articular cartilage is thought to represent a major risk factor for osteoarthritis development. In this study we aimed to probe the role of AGEs in human chondrocytes and to determine the impact of the peroxisome proliferator-activated receptor-γ (PPARG) on AGEs-induced cell autophagy. Cell viability was measured after human chondrocytes were treated with different concentrations of AGEs with or without the PPARG inhibitor, T0070907, or agonist, pioglitazone...
February 17, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29453235/a-workforce-survey-on-developmental-behavioral-pediatrics
#20
Carolyn Bridgemohan, Nerissa S Bauer, Britt A Nielsen, Anne DeBattista, Holly S Ruch-Ross, Linda B Paul, Nancy Roizen
BACKGROUND AND OBJECTIVES: Developmental-behavioral conditions are common, affecting ∼15% of US children. The prevalence and complexity of these conditions are increasing despite long wait times and a limited pipeline of new providers. We surveyed a convenience sample of the developmental-behavioral pediatric (DBP) workforce to determine current practices, workforce trends, and future needs. METHODS: An electronic survey was e-mailed to 1568 members of the American Academy of Pediatrics Section on Developmental and Behavioral Pediatrics and Council on Children with Disabilities, the Society for Developmental and Behavioral Pediatrics, and the National Association of Pediatric Nurse Practitioners Developmental and Behavioral Mental Health Special Interest Group...
February 16, 2018: Pediatrics
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