Ling Li, Bao-Jia Zou, Juan-Zhi Zhao, Jia-Bi Liang, Zi-Yue She, Wen-Ying Zhou, Si-Xiao Lin, Lin Tian, Wen-Ji Luo, Fa-Zhong He
DNA damage repair (DDR) is essential for maintaining genome integrity and modulating cancer risk, progression, and therapeutic response. DDR defects are common among non-small lung cancer (NSCLC), resulting in new challenge and promise for NSCLC treatment. Thus, a thorough understanding of the molecular characteristics of DDR in NSCLC is helpful for NSCLC treatment and management. Here, we systematically analyzed the relationship between DDR alterations and NSCLC prognosis, and successfully established and validated a six-DDR gene prognostic model via LASSO Cox regression analysis based on the expression of prognostic related DDR genes, CDC25C , NEIL3 , H2AFX , NBN , XRCC5 , RAD1 ...
2022: Frontiers in Oncology