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neil3 and cancer

Y S Kim, Y Kim, J W Choi, H E Oh, J H Lee
This study explored candidate causal single nucleotide polymorphisms (SNPs) to clarify the biological mechanism of prostate cancer (PCa). Identify candidate Causal SNPs and Pathways (ICSNPathway) analysis was applied using a PCa genome-wide association study (GWAS) dataset that included 473,736 SNPs in 1151 cases of PCa and 1156 controls of European ancestry. Five candidate causal SNPs, three candidate causal genes, and two candidate causal pathways were identified using integrating linkage disequilibrium analysis, functional SNP annotation, and pathway-based analysis...
2016: Neoplasma
Monica Cipollini, Gisella Figlioli, Giuseppe Maccari, Sonia Garritano, Chiara De Santi, Ombretta Melaiu, Elisa Barone, Franco Bambi, Stefano Ermini, Giovanni Pellegrini, Alfonso Cristaudo, Rudy Foddis, Alessandra Bonotti, Cristina Romei, Agnese Vivaldi, Laura Agate, Eleonora Molinari, Roberto Barale, Asta Forsti, Kari Hemminki, Rossella Elisei, Federica Gemignani, Stefano Landi
The thyrocytes are exposed to high levels of oxidative stress which could induce DNA damages. Base excision repair (BER) is one of the principal mechanisms of defense against oxidative DNA damage, however recent evidences suggest that also nucleotide excision repair (NER) could be involved. The aim of present work was to identify novel differentiated thyroid cancer (DTC) risk variants in BER and NER genes. For this purpose, the most strongly associated SNPs within NER and BER genes found in our previous GWAS on DTC were selected and replicated in an independent series of samples for a new case-control study...
May 2016: DNA Repair
Kazuya Shinmura, Hisami Kato, Yuichi Kawanishi, Hisaki Igarashi, Masanori Goto, Hong Tao, Yusuke Inoue, Satoki Nakamura, Kiyoshi Misawa, Hiroyuki Mineta, Haruhiko Sugimura
The effects of abnormalities in the DNA glycosylases NEIL1, NEIL2, and NEIL3 on human cancer have not been fully elucidated. In this paper, we found that the median somatic total mutation loads and the median somatic single nucleotide mutation loads exhibited significant inverse correlations with the median NEIL1 and NEIL2 expression levels and a significant positive correlation with the median NEIL3 expression level using data for 13 cancer types from the Cancer Genome Atlas (TCGA) database. A subset of the cancer types exhibited reduced NEIL1 and NEIL2 expressions and elevated NEIL3 expression, and such abnormal expressions of NEIL1, NEIL2, and NEIL3 were also significantly associated with the mutation loads in cancer...
2016: Oxidative Medicine and Cellular Longevity
Aaron M Fleming, Jia Zhou, Susan S Wallace, Cynthia J Burrows
Uncontrolled inflammation or oxidative stress generates electron-deficient species that oxidize the genome increasing its instability in cancer. The G-quadruplex (G4) sequences regulating the c-MYC, KRAS, VEGF, BCL-2, HIF-1α, and RET oncogenes, as examples, are targets for oxidation at loop and 5'-core guanines (G) as showcased in this study by CO3(•-) oxidation of the VEGF G4. Products observed include 8-oxo-7,8-dihydroguanine (OG), spiroiminodihydantoin (Sp), and 5-guanidinohydantoin (Gh). Our previous studies found that OG and Gh, when present in the four G-tracks of the solved structure for VEGF and c-MYC, were not substrates for the base excision repair (BER) DNA glycosylases in biologically relevant KCl solutions...
August 26, 2015: ACS Central Science
Jaime Matta, Luisa Morales, Julie Dutil, Manuel Bayona, Carolina Alvarez, Erick Suarez
Previous studies have found a link between a low DNA repair capacity (DRC) level and increased risk for breast cancer (BC). A recent study by Matta et al. 2012 showed that women with BC have an average reduction of 60% in DRC compared to controls (P < 0.001). Using the same group of Hispanic women, we selected a subgroup of cases (n=35) and controls (n=2) who donated their tumors and normal tissue for performing molecular studies in order to 1) compare the expression of DNA repair genes in breast tissue between BC cases and controls without this disease, 2) assess the correlation between gene expression and DRC levels, 3) examine whether DRC levels are associated with tumor DNA repair gene expression profiling when women were stratified according to their hormone receptor status...
February 1, 2013: Molecular Cancer Biology
Sanja A Farkas, Veronika Vymetalkova, Ludmila Vodickova, Pavel Vodicka, Torbjörn K Nilsson
AIM: The onset and progression of colorectal cancer (CRC) involves a cascade of genetic and/or epigenetic events. The aim of the present study was to address the DNA methylation status of genes relevant in colorectal carcinogenesis and its progression, such as genes frequently mutated in CRC, genes involved in the DNA repair and Wnt signaling pathway. MATERIAL & METHODS: We analyzed methylation status in totally 160 genes in 12 paired colorectal tumors and adjacent healthy mucosal tissues using the Illumina Infinium Human Methylation 450 BeadChip...
April 2014: Epigenomics
Jian Gong, Li Hsu, Tabitha Harrison, Irena B King, Stefan Stürup, Xiaoling Song, David Duggan, Yan Liu, Carolyn Hutter, Stephen J Chanock, Charles B Eaton, James R Marshall, Ulrike Peters
Selenium is an essential trace element and circulating selenium concentrations have been associated with a wide range of diseases. Candidate gene studies suggest that circulating selenium concentrations may be impacted by genetic variation; however, no study has comprehensively investigated this hypothesis. Therefore, we conducted a two-stage genome-wide association study to identify genetic variants associated with serum selenium concentrations in 1203 European descents from two cohorts: the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening and the Women's Health Initiative (WHI)...
May 2013: Nutrients
Veslemøy Rolseth, Silje Zandstra Krokeide, David Kunke, Christine Gran Neurauter, Rajikala Suganthan, Yngve Sejersted, Gunn Annette Hildrestrand, Magnar Bjørås, Luisa Luna
7,8-Dihydro-8-oxoguanine (8-oxoG) is one of the most common oxidative base lesions in normal tissues induced by a variety of endogenous and exogenous agents. Hydantoins are products of 8-oxoG oxidation and as 8-oxoG, they have been shown to be mutagenic lesions. Oxidative DNA damage has been implicated in the etiology of various age-associated pathologies, such as cancer, cardiovascular diseases, arthritis, and several neurodegenerative diseases. The mammalian endonuclease VIII-like 3 (Neil3) is one of the four DNA glycosylases found to recognize and remove hydantoins in the first step of base excision repair (BER) pathway...
May 2013: Biochimica et Biophysica Acta
Kathryn Hughes Barry, Stella Koutros, Sonja I Berndt, Gabriella Andreotti, Jane A Hoppin, Dale P Sandler, Laurie A Burdette, Meredith Yeager, Laura E Beane Freeman, Jay H Lubin, Xiaomei Ma, Tongzhang Zheng, Michael C R Alavanja
BACKGROUND: Previous research indicates increased prostate cancer risk for pesticide applicators and pesticide manufacturing workers. Although underlying mechanisms are unknown, evidence suggests a role of oxidative DNA damage. OBJECTIVES: Because base excision repair (BER) is the predominant pathway involved in repairing oxidative damage, we evaluated interactions between 39 pesticides and 394 tag single-nucleotide polymorphisms (SNPs) for 31 BER genes among 776 prostate cancer cases and 1,444 male controls in a nested case-control study of white Agricultural Health Study (AHS) pesticide applicators...
December 2011: Environmental Health Perspectives
A R Dallosso, S Dolwani, N Jones, S Jones, J Colley, J Maynard, S Idziaszczyk, V Humphreys, J Arnold, A Donaldson, D Eccles, A Ellis, D G Evans, I M Frayling, F J Hes, R S Houlston, E R Maher, M Nielsen, S Parry, E Tyler, V Moskvina, J P Cheadle, J R Sampson
BACKGROUND: MUTYH-associated polyposis (MAP) is a recessive trait characterised by multiple colorectal adenomas and a high risk of colorectal cancer. MUTYH functions in the DNA base excision repair pathway and has a key role in the repair of oxidative DNA damage. OBJECTIVES: To assess the contribution of inherited variants in genes involved in base excision repair and oxidative DNA damage including MUTYH, OGG1, NEIL1, NEIL2, NEIL3, NUDT1 and NTH1 to the multiple colorectal adenoma phenotype...
September 2008: Gut
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