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https://www.readbyqxmd.com/read/29141062/management-of-severe-acne-vulgaris-with-topical-therapy
#1
Linda Stein Gold, Hilary E Baldwin, Tina Lin
<p>Acne vulgaris (acne) is the most common skin disease we see in dermatology practice. Although rare in childhood, severe acne can affect up to 12% of the adolescent population. A chronic disease, it requires both aggressive management and effective maintenance strategies. Oral antibiotics, in combination with topical agents are recommended for treatment, with topical agents being continued as maintenance therapy to minimize resistance and recurrence. However, concerns with systemic side effects have recently resulted in a greater focus on the potential of fixed combination topical therapies to treat severe acne...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29141057/lasers-light-and-the-treatment-of-acne-a-comprehensive-review-of-the-literature
#2
Lana X Tong, Jeremy A Brauer
INTRODUCTION: Acne vulgaris is common dermatologic condition with an estimated prevalence of 70 to 87%. Acne has been shown to have a significant impact on patient quality of life and mental health, especially as inflammatory lesions typically occur on cosmetically sensitive areas with the potential for permanent scarring. There have been numerous advances in the treatment of inflammatory acne with light-based and laser devices. OBJECTIVE: To review the current evidence for light-based and laser treatments in the management of inflammatory acne...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29140537/using-normal-and-high-pulse-coverage-with-picosecond-laser-treatment-of-wrinkles-and-acne-scarring-long-term-clinical-observations
#3
Christine Dierickx
OBJECTIVE: The picosecond 755 nm alexandrite laser using a diffractive lens array has demonstrated consistent clinical efficacy for improving the appearance of acne scarring and wrinkles amongst other benefits. This small pilot study is to assess the difference, if any, in clinical benefit if a higher than the standard protocol for number of pulses delivered to a tissue area is used compared to the standard protocol guidelines. METHOD: Seven subjects received treatment to one side of the face with a standard protocol number of laser pulses with the other side of the face receiving higher than standard number of pulses from the same 755 nm picosecond laser using an additional diffractive lens array...
November 15, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29137705/novel-approach-to-high-throughput-determination-of-endocrine-disruptors-using-recycled-diatomaceous-earth-as-a-green-sorbent-phase-for-thin-film-solid-phase-microextraction-combined-with-96-well-plate-system
#4
Nicolas Kirschner, Adriana Neves Dias, Dilma Budziak, Cristian Berto da Silveira, Josias Merib, Eduardo Carasek
A sustainable approach to TF-SPME is presented using recycled diatomaceous earth, obtained from a beer purification process, as a green sorbent phase for the determination of bisphenol A (BPA), benzophenone (BzP), triclocarban (TCC), 4-methylbenzylidene camphor (4-MBC) and 2-ethylhexyl-p-methoxycinnamate (EHMC) in environmental water samples. TF-SPME was combined with a 96-well plate system allowing for high-throughput analysis due to the simultaneous extraction/desorption up to 96 samples. The proposed sorbent phase exhibited good stability in organic solvents, as well as satisfactory analytical performance...
December 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29136261/decrease-in-diversity-of-propionibacterium-acnes-phylotypes-in-patients-with-severe-acne-on-the-back
#5
Marie-Ange Dagnelie, Stéphane Corvec, Mélanie Saint-Jean, Valérie Bourdès, Jean-Michel Nguyen, Amir Khammari, Brigitte Dréno
Propionibacterium acnes, a major member of normal skin microbiota, is subdivided into 6 phylotypes: IA1, IA2, IB, IC, II and III. This study investigated P. acnes subgroups on the face and back in patients with severe acne and in healthy controls. In 71.4% of patients with severe acne, P. acnes phylotypes were identical on the face and back, whereas this was the case in only 45.5% of healthy controls. The healthy group carried phylotypes IA1 (39.1%) and II (43.4%), whereas the acne group carried a high predominance of IA1 (84...
November 14, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29130770/transition-state-analogue-imprinted-polymers-as-artificial-amidases-for-amino-acid-p-nitroanilides-morphological-effects-of-polymer-network-on-catalytic-efficiency
#6
Divya Mathew, Benny Thomas, K S Devaky
The morphology of the polymer network - porous/less porous - plays predominant role in the amidase activities of the polymer catalysts in the hydrolytic reactions of amino acid p-nitroanilides. Polymers with the imprints of stable phosphonate analogue of the intermediate of hydrolytic reactions were synthesized as enzyme mimics. Molecular imprinting was carried out in thermodynamically stable porogen dimethyl sulphoxide and unstable porogen chloroform, to investigate the morphological effects of polymers on catalytic amidolysis...
November 13, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29123243/immunohistochemical-detection-of-propionibacterium-acnes-in-the-retinal-granulomas-in-patients-with-ocular-sarcoidosis
#7
Kenji Nagata, Yoshinobu Eishi, Keisuke Uchida, Kazuhito Yoneda, Hiroki Hatanaka, Toru Yasuhara, Maho Nagata, Chie Sotozono, Shigeru Kinoshita
The etiology of sarcoidosis is still obscure; however, Mycobacteria and Propionibacterium acnes are considered the most implicated etiological agent for sarcoidosis. To investigate whether P. acnes is an etiological agent for sarcoid uveitis, we analyzed the frequency of P. acnes detected within the biopsied retinas from patients with ocular sarcoidosis by immunohistochemistry with a P. acnes-specific monoclonal antibody (PAB antibody). Eleven patients (12 eyes) with sarcoid uveitis were enrolled in this study...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29111493/lateral-cutaneous-nerve-entrapment-syndrome-lacnes-a-previously-unrecognized-cause-of-intractable-flank-pain
#8
R C Maatman, N E Papen-Botterhuis, M R M Scheltinga, R M H Roumen
BACKGROUND AND AIMS: Chronic abdominal pain may occasionally be due to terminal endings of intercostal nerves (ACNES, abdominal cutaneous nerve entrapment syndrome) that are entrapped in the abdominal wall. Spontaneous neuropathic flank pain may also be caused by involvement of branches of these intercostal nerves. Aim is to describe a series of patients with flank pain due to nerve entrapment and to increase awareness for an unknown condition coined Lateral Cutaneous Nerve Entrapment Syndrome (LACNES)...
October 27, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29110752/heritability-and-gwas-analyses-of-acne-in-australian-adolescent-twins
#9
Angela Mina-Vargas, Lucía Colodro-Conde, Katrina Grasby, Gu Zhu, Scott Gordon, Sarah E Medland, Nicholas G Martin
Acne vulgaris is a skin disease with a multifactorial and complex pathology. While several twin studies have estimated that acne has a heritability of up to 80%, the genomic elements responsible for the origin and pathology of acne are still undiscovered. Here we performed a twin-based structural equation model, using available data on acne severity for an Australian sample of 4,491 twins and their siblings aged from 10 to 24. This study extends by a factor of 3 an earlier analysis of the genetic factors of acne...
November 7, 2017: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/29108811/the-antimicrobial-effect-of-cen1hc-br-against-propionibacterium-acnes-and-its-therapeutic-and-anti-inflammatory-effects-on-acne-vulgaris
#10
Rui Han, Hans-Matti Blencke, Hao Cheng, Chun Li
Propionibacterium acnes is a commensal bacterium, which is involved in acne inflammation. An antimicrobial peptide named CEN1HC-Br, which was isolated and characterized form the green sea urchin, has been shown to possess broad-spectrum antibacterial activity. Little is known concerning the potential effects of its antibacterial and anti-inflammatory properties against P. acnes. To examine the potency of CEN1HC-Br in acne treatment, we conducted experiments to analyze the antibacterial and anti-inflammatory activities of CEN1HC-Br both in vitro and in vivo...
November 3, 2017: Peptides
https://www.readbyqxmd.com/read/29104722/skin-surface-ph-in-acne-vulgaris-insights-from-an-observational-study-and-review-of-the-literature
#11
Chaitra Prakash, Puneet Bhargava, Siddhi Tiwari, Banashree Majumdar, Rishi Kumar Bhargava
OBJECTIVE: Recurrent and chronic course of acne vulgaris, despite effect-proven therapies, point to an underfocused aspect in its pathogenesis and management. This study aims to assess in subjects with and without acne, the skin surface pH, a parameter that cumulatively represents functioning of various units of skin, including the barrier. METHODS: A total of 200 patients with acne and 200 age- and sex-matched controls were included. Under basal conditions, facial skin pH was derived from five sites using a skin pH-meter...
July 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29104719/discovering-black-soap-a-survey-on-the-attitudes-and-practices-of-black-soap-users
#12
Ann Lin, Adam Nabatian, Caroline P Halverstam
OBJECTIVE: The purpose of this study was to discover the general attitudes and practices of black soap users with regard to amelioration of various dermatologic conditions. DESIGN: This was a prospective questionnaire-based study with a sample size of 100 black soap users. Setting: Outpatient dermatology clinics of Montefiore Medical Center and other Albert Einstein affiliated dermatology clinics in Bronx, New York. PARTICIPANTS: One hundred subjects who have used black soap were recruited. MEASUREMENTS: The participants evaluated and reported their attitudes and applications of black soap...
July 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29095531/low-level-red-led-light-inhibits-hyperkeratinization-and-inflammation-induced-by-unsaturated-fatty-acid-in-an-in-vitro-model-mimicking-acne
#13
Wen-Hwa Li, Ali Fassih, Curt Binner, Ramine Parsa, Michael D Southall
BACKGROUND AND OBJECTIVE: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous units (PSU), associated with increased sebum production, abnormal follicular keratinization (hyperkeratinization), follicular overgrowth of Propionibacterium acnes (P. acnes), and increased inflammatory mediator release. Light therapy has attracted medical interests as a safe alternative treatment for acne. Both blue and red light therapies at high doses >10 J/cm(2) have demonstrated marked effects on inflammatory acne lesions...
November 2, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29091937/phenome-wide-association-study-using-research-participants-self-reported-data-provides-insight-into-the-th17-and-il-17-pathway
#14
Margaret G Ehm, Jennifer L Aponte, Mathias N Chiano, Laura M Yerges-Armstrong, Toby Johnson, Jonathan N Barker, Suzanne F Cook, Akanksha Gupta, David A Hinds, Li Li, Matthew R Nelson, Michael A Simpson, Chao Tian, Linda C McCarthy, Deepak K Rajpal, Dawn M Waterworth
A phenome-wide association study of variants in genes in the Th17 and IL-17 pathway was performed using self-reported phenotypes and genetic data from 521,000 research participants of 23andMe. Results replicated known associations with similar effect sizes for autoimmune traits illustrating self-reported traits can be a surrogate for clinically assessed conditions. Novel associations controlling for a false discovery rate of 5% included the association of the variant encoding p.Ile684Ser in TYK2 with increased risk of tonsillectomy, strep throat occurrences and teen acne, the variant encoding p...
2017: PloS One
https://www.readbyqxmd.com/read/29072375/efficacy-of-microneedling-with-70-glycolic-acid-peel-vs-microneedling-alone-in-treatment-of-atrophic-acne-scars-a-randomized-controlled-trial
#15
Shiwangi Rana, Vibhu Mendiratta, Ram Chander
BACKGROUND: Microneedling with dermaroller and glycolic acid peels is commonly used for treatment of acne scars. OBJECTIVE: To compare efficacy of microneedling alone versus combination of microneedling with serial 70% glycolic acid peel in management of atrophic acne scars. METHODS & MATERIALS: Sixty patients with atrophic acne scars were randomized into group 1 receiving microneedling at 0, 6, and 12 weeks and group 2 receiving microneedling at 0, 6, and 12 weeks along with 70% glycolic acid peel at 3, 9, and 15 weeks...
October 26, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29066297/medicinal-mascarene-aloes-an-audit-of-their-phytotherapeutic-potential
#16
D Lobine, I Cummins, J Govinden-Soulange, M Ranghoo-Sanmukhiya, K Lindsey, P L Chazot, C A Ambler, S Grellscheid, G Sharples, N Lall, I A Lambrechts, C Lavergne, M-J R Howes
A phytochemical and biological investigation of the endemic Mascarene Aloes (Aloe spp.), including A. tormentorii (Marais) L.E.Newton & G.D.Rowley, A. purpurea Lam, A. macra Haw., A. lomatophylloides Balf.f and A. vera (synonym A. barbadensis Mill.), which are used in the traditional folk medicine of the Mascarene Islands, was initiated. Methanolic extracts of the Aloes under study were analysed using high resolution LC-UV-MS/MS and compounds belonging to the class of anthraquinones, anthrones, chromones and flavone C-glycosides were detected...
October 21, 2017: Fitoterapia
https://www.readbyqxmd.com/read/29065893/neuropsychological-and-internalizing-problems-in-acute-central-nervous-system-infections-a-1-year-follow-up
#17
Bozzola Elena, Bergonzini Paola, Bozzola Mauro, Tozzi Alberto Eugenio, Masci Marco, Rossetti Chiara, Carloni Emanuela, Villani Alberto
BACKGROUND: Acute central nervous system (ACNS) infections such as meningitis, encephalitis and cerebellitis still cause morbidity and mortality among children. The aim of this study was to verify whether neuropsychological impairment may develop in ACNS survivors. METHODS: The study included pediatric patients affected by ACNS disorders, aged 3-16 years admitted to the Bambino Gesù Children Hospital, Rome from June 2013 till June 2015. The patients and their parents underwent a psychological interview and neuropsychological tests during the first week of hospital admission and 1 year after, during a follow-up control...
October 24, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29058290/mental-health-status-assessment-in-polycystic-ovarian-syndrome-infertility-patients-a-pilot-study
#18
Sai-Jiao Li, Dan-Ni Zhou, Wei Li, Jing Yang
Polycystic ovary syndrome (PCOS) is a major endocrine disorder afflicting women of reproductive age. Women with PCOS are more likely to suffer from mental health disturbances than healthy women. The "infertility" suffered by PCOS patients would also lead to mental health disturbances. Symptom Checklist 90 (SCL-90) and questionnaire which includes patients' socio-economic and demographic data were used to assess the mental health status of PCOS (n=103) and non-PCOS (n=110) infertile patients. Logistic regression analysis and t-tests were used for comparative analysis...
October 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/29052890/guidelines-for-the-management-of-acne-recommendations-from-a-french-multidisciplinary-group
#19
L Le Cleach, B Lebrun-Vignes, A Bachelot, F Beer, P Berger, S Brugère, M Chastaing, G Do-Pham, T Ferry, J Gand-Gavanou, B Guigues, O Join-Lambert, P Henry, R Khallouf, E Lavie, A Maruani, O Romain, B Sassolas, V T Tran, B Guillot
No abstract text is available yet for this article.
October 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29037535/performance-of-implant-sonication-culture-for-the-diagnosis-of-periprosthetic-shoulder-infection
#20
Matthew J Grosso, Salvatore J Frangiamore, George Yakubek, Thomas W Bauer, Joseph P Iannotti, Eric T Ricchetti
BACKGROUND: Diagnosing infection after shoulder arthroplasty can be a challenge because of the high prevalence of low-virulence organisms, such as Propionibacterium acnes. The purpose of this study was to evaluate the utility of implant sonication fluid cultures in the diagnosis of periprosthetic joint infection compared with standard culture techniques in patients undergoing revision shoulder arthroplasty. METHODS: Routine perioperative testing was performed in 53 patients who underwent revision shoulder arthroplasty...
October 13, 2017: Journal of Shoulder and Elbow Surgery
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