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CD173

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https://www.readbyqxmd.com/read/21418181/expression-of-blood-group-genes-by-mesenchymal-stem-cells
#1
Richard Schäfer, Martina Schnaidt, Roland A Klaffschenkel, Georg Siegel, Michael Schüle, Maria Anna Rädlein, Ursula Hermanutz-Klein, Miriam Ayturan, Marine Buadze, Christoph Gassner, Lusine Danielyan, Torsten Kluba, Hinnak Northoff, Willy A Flegel
Incompatible blood group antigens are highly immunogenic and can cause graft rejections. Focusing on distinct carbohydrate- and protein-based membrane structures, defined by blood group antigens, we investigated human bone marrow-derived mesenchymal stem cells (MSCs) cultured in human serum. The presence of H (CD173), ABO, RhD, RhCE, RhAG, Kell, urea transporter type B (SLC14A1, previously known as JK), and Duffy antigen receptor of chemokines (DARC) was evaluated at the levels of genome, transcriptome and antigen...
May 2011: British Journal of Haematology
https://www.readbyqxmd.com/read/20300773/co-expression-of-cd173-h2-and-cd174-lewis-y-with-cd44-suggests-that-fucosylated-histo-blood-group-antigens-are-markers-of-breast-cancer-initiating-cells
#2
Wei-Ming Lin, Uwe Karsten, Steffen Goletz, Ruo-Chuan Cheng, Yi Cao
Histo-blood group antigens CD173 (H2) and CD174 (Lewis Y) are known to be developmentally regulated carbohydrate antigens which are expressed to a varying degree on many human carcinomas. We hypothesized that they might represent markers of cancer-initiating cells (or cancer stem cells, CSC). In order to test this hypothesis, we examined the co-expression of CD173 and CD174 with stem cell markers CD44 and CD133 by flow cytometry analysis, immunocytochemistry, and immunohistochemistry on cell lines and tissue sections from breast cancer...
April 2010: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/18205178/involvement-of-alpha-1-2-fucosyltransferase-i-fut1-and-surface-expressed-lewis-y-cd174-in-first-endothelial-cell-cell-contacts-during-angiogenesis
#3
Thomas M Moehler, Sandra Sauer, Maximilian Witzel, Mindaugas Andrulis, Juan J Garcia-Vallejo, Rainer Grobholz, Martina Willhauck-Fleckenstein, Axel Greiner, Hartmut Goldschmidt, Reinhard Schwartz-Albiez
During the initiation of tumor associated angiogenesis endothelial cells migrate, adhere to extracellular matrix and form cell-cell contacts. Humoral factors of malignant cells conduct this process. We investigated whether cell surface expression of the carbohydrate blood group determinant Lewis(y) (CD174) and its precursor structure H2 (CD173) on endothelial cells is influenced by soluble factors of tumor cells. Using a bone marrow derived endothelial cell line we observed an enhanced expression of CD173/CD174 and transcription of FUT1, the key enzyme for their synthesis, after treatment with tumor necrosis factor-alpha (TNF-alpha) or conditioned supernatants of the leukemia cell line KG1a...
April 2008: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/11479278/the-fucosylated-histo-blood-group-antigens-h-type-2-blood-group-o-cd173-and-lewis-y-cd174-are-expressed-on-cd34-hematopoietic-progenitors-but-absent-on-mature-lymphocytes
#4
Y Cao, A Merling, U Karsten, R Schwartz-Albiez
The expression of LeY, H2, H3, and H4 on a broad variety of human leukemia cell lines and native lymphocytes as well as on CD34+ hematopoietic progenitor cells was examined by flow cytometry and immunocytochemistry. CD34+ leukemia cell lines (KG1, KG1a, and TF1) and native CD34+ hematopoietic progenitor cells expressed H2 (CD173) and LeY (CD174). In contrast, CD34(-) cell lines (HL-60, U937, JOK-1, Raji, Molt-3, Jurkat, and CEM-C7) and mature lymphocytes from peripheral blood and tonsils lacked CD173 and CD174...
August 2001: Glycobiology
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