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https://www.readbyqxmd.com/read/29440699/vascular-dysfunction-in-obese-diabetic-db-db-mice-involves-the-interplay-between-aldosterone-mineralocorticoid-receptor-and-rho-kinase-signaling
#1
Aurelie Nguyen Dinh Cat, Glaucia E Callera, Malou Friederich-Persson, Ana Sanchez, Maria Gabriela Dulak-Lis, Sofia Tsiropoulou, Augusto C Montezano, Ying He, Ana M Briones, Frederic Jaisser, Rhian M Touyz
Activation of aldosterone/mineralocorticoid receptors (MR) has been implicated in vascular dysfunction of diabetes. Underlying mechanisms are elusive. Therefore, we investigated the role of Rho kinase (ROCK) in aldosterone/MR signaling and vascular dysfunction in a model of diabetes. Diabetic obese mice (db/db) and control counterparts (db/+) were treated with MR antagonist (MRA, potassium canrenoate, 30 mg/kg/day, 4 weeks) or ROCK inhibitor, fasudil (30 mg/kg/day, 3 weeks). Plasma aldosterone was increased in db/db versus db/+...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29439489/the-low-renin-hypertension-phenotype-genetics-and-the-role-of-the-mineralocorticoid-receptor
#2
REVIEW
Rene Baudrand, Anand Vaidya
A substantial proportion of patients with hypertension have a low or suppressed renin. This phenotype of low-renin hypertension (LRH) may be the manifestation of inherited genetic syndromes, acquired somatic mutations, or environmental exposures. Activation of the mineralocorticoid receptor is a common final mechanism for the development of LRH. Classically, the individual causes of LRH have been considered to be rare diseases; however, recent advances suggest that there are milder and "non-classical" variants of many LRH-inducing conditions...
February 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29437893/selective-mineralocorticoid-receptor-cofactor-modulation-as-molecular-basis-for-finerenone-s-antifibrotic-activity
#3
Jana Grune, Niklas Beyhoff, Elia Smeir, Remigiusz Chudek, Annelie Blumrich, Zsofia Ban, Sarah Brix, Iris R Betz, Michael Schupp, Anna Foryst-Ludwig, Robert Klopfleisch, Philipp Stawowy, René Houtman, Peter Kolkhof, Ulrich Kintscher
Mineralocorticoid receptor antagonists (MRAs) reduce morbidity and mortality in chronic heart failure. Novel nonsteroidal MRAs are currently developed and need to be pharmacologically characterized in comparison to classical steroidal MRAs. A mouse model of cardiac fibrosis induced by short-term isoproterenol injection was used to compare the nonsteroidal MRA finerenone and the steroidal MRA eplerenone in equi-efficient systemic MR blocking dosages. Molecular mechanisms were studied in MR-expressing H9C2/MR+ cardiomyocytes and in MR transcriptional cofactor binding assays...
February 5, 2018: Hypertension
https://www.readbyqxmd.com/read/29430402/effects-of-mineralocorticoid-receptor-antagonists-on-responses-to-hemorrhagic-shock-in-rats
#4
Kanako Yamamoto, Takashi Yamamoto, Masayuki Takamura, Soichiro Usui, Hisayoshi Murai, Shuichi Kaneko, Takumi Taniguchi
AIM: To evaluate the effects of mineralocorticoid receptor (MR) antagonists on mortality and inflammatory responses after hemorrhagic shock (HS) in rats. METHODS: One hundred and two male Sprague-Dawley rats were randomly assigned to one of the following three groups: Control, spironolactone (SPL), and eplerenone (EP) groups. HS was induced by the removal of blood. One half of rats were evaluated to determine mortality, hemodynamics, plasma tumor necrosis factor-alpha (TNF-α) concentrations, and arterial blood gas at 8 h after HS recovery...
February 4, 2018: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29428549/importance-of-the-brain-corticosteroid-receptor-balance-in-metaplasticity-cognitive-performance-and-neuro-inflammation
#5
REVIEW
E R de Kloet, O C Meijer, A F de Nicola, R H de Rijk, M Joëls
Bruce McEwen's discovery of receptors for corticosterone in the rat hippocampus introduced higher brain circuits in the neuroendocrinology of stress. Subsequently, these receptors were identified as mineralocorticoid receptors (MRs) that are involved in appraisal processes, choice of coping style, encoding and retrieval. The MR-mediated actions on cognition are complemented by slower actions via glucocorticoid receptors (GRs) on contextualization, rationalization and memory storage of the experience. These sequential phases in cognitive performance depend on synaptic metaplasticity that is regulated by coordinate MR- and GR activation...
February 8, 2018: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/29427591/steroid-regulation-an-overlooked-aspect-of-tolerance-and-chronic-rejection-in-kidney-transplantation
#6
Sofia Christakoudi, Manohursingh Runglall, Paula Mobillo, Irene Rebollo-Mesa, Tjir-Li Tsui, Estefania Nova-Lamperti, Sonia Norris, Yogesh Kamra, Rachel Hilton
Steroid conversion (HSD11B1, HSD11B2, H6PD) and receptor genes (NR3C1, NR3C2) were examined in kidney-transplant recipients with "operational tolerance" and chronic rejection (CR), independently and within the context of 88 tolerance-associated genes. Associations with cellular types were explored. Peripheral whole-blood gene-expression levels (RT-qPCR-based) and cell counts were adjusted for immunosuppressant drug intake. Tolerant (n = 17), stable (n = 190) and CR patients (n = 37) were compared...
February 7, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29422652/rage-aptamer-attenuates-deoxycorticosterone-acetate-salt-induced-renal-injury-in-mice
#7
Kensei Taguchi, Sho-Ichi Yamagishi, Miyuki Yokoro, Sakuya Ito, Goh Kodama, Yusuke Kaida, Yosuke Nakayama, Ryotaro Ando, Nana Yamada-Obara, Katsuhiko Asanuma, Takanori Matsui, Yuichiro Higashimoto, Craig R Brooks, Seiji Ueda, Seiya Okuda, Kei Fukami
The mineralocorticoid receptor (MR) and its downstream signaling play an important role in hypertensive renal injury. The interaction of advanced glycation end products (AGE) with their receptor (RAGE) is involved in the progression of renal disease. However, the pathological crosstalk between AGE-RAGE axis and MR system in kidney derangement remains unclear. We screened DNA-aptamer directed against RAGE (RAGE-apt) in vitro and examined its effects on renal injury in uninephrectomized deoxycorticosterone acetate (DOCA)/salt-induced hypertensive mice...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29421306/prenatal-cold-stress-effect-on-maternal-hippocampus-and-offspring-behavior-in-rats
#8
Shuai Lian, Di Wang, Bin Xu, Wenjin Guo, Lipeng Wang, Wenjie Li, Hong Ji, Jianfa Wang, Fanzhi Kong, Li Zhen, Shize Li, Liping Zhang, Jingru Guo, Huanmin Yang
In mammals, environmental factors including cold stress exert dramatic effects on adult health during late gestation, the cold stress response refers to an organism's response to cold. Indeed, cells and organs, including the hippocampus, are coordinated to respond to prevent hypothermia. The hippocampus act as an important brain structure that regulates the activity of the hypothalamic-pituitary-adrenal (HPA) axis, and suppress the stress reaction through feedback regulation of the HPA axis. To evaluate the response of the hippocampus during prenatal cold stress, we established a prenatal cold stress rat model...
February 5, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29416526/aldosterone-blocks-rat-stem-leydig-cell-development-in-vitro
#9
Jingwei Zhang, Bisheng Huang, Guanghui Hu, Xiangcheng Zhan, Tiancheng Xie, Saiyang Li, Xiaolu Zhang, Huitao Li, Ren-Shan Ge, Yunfei Xu
Aldosterone (ALDO) is a primary endogenous mineralocorticoid, appearing as the main hormone controlling sodium and water homeostasis. Its emerging role in the development of many organs has gained interest over the past few years. In the testis, Leydig cells contain mineralocorticoid receptors and ALDO stimulates androgen synthesis via the mineralocorticoid receptors in rat adult Leydig cells. Although ALDO pharmacologically promoted the Leydig cell function, its role in Leydig cell development was unclear...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29414008/analysis-by-lc-ms-ms-of-endogenous-steroids-from-human-serum-plasma-endometrium-and-endometriotic-tissue
#10
Merja R Häkkinen, Taija Heinosalo, Niina Saarinen, Tero Linnanen, Raimo Voutilainen, Timo Lakka, Jarmo Jääskeläinen, Matti Poutanen, Seppo Auriola
An LC-MS/MS method was developed and validated to analyze simultaneously estrogens (estradiol, E2; estrone, E1), androgens (testosterone, T; androstenedione, A4; dehydroepiandrosterone, DHEA), progestagens (17a-hydroxypregnenolone, 17OHP5; 17a-hydroxyprogesterone, 17OHP4; progesterone, P4), glucocorticoids (cortisol, F; cortisone E; corticosterone, B; 11-deoxycortisol, S; 21-hydroxyprogesterone, 21OHP4), and mineralocorticoids (aldosterone, A) from 150 μl of human serum, plasma, or endometrium and endometriotic tissue homogenates...
January 31, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29411216/pharmacological-treatments-for-heart-failure-with-preserved-ejection-fraction-a-systematic-review-and-indirect-comparison
#11
REVIEW
Kwadwo Osei Bonsu, Poukwan Arunmanakul, Nathorn Chaiyakunapruk
Pharmacological interventions for heart failure with preserved ejection fraction (HFpEF) have failed to reduce mortality and hospitalization. Evidence for mineralocorticoid antagonists (MRAs), β-adrenoceptor blockers (β-blockers), and angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEIs/ARBs)-to reduce clinical outcomes in HFpEF remains unclear. We conducted a systematic search of MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and Clinical Trials.gov for randomized controlled trials (RCTs) assessing pharmacological treatments in HFpEF diagnosed according the recommendations of the European Society of Cardiology (ESC) 2016 guidelines from inception to August, 2017...
February 7, 2018: Heart Failure Reviews
https://www.readbyqxmd.com/read/29408681/housing-environment-influences-stress-related-hippocampal-substrates-and-depression-like-behavior
#12
Archana Ashokan, Akshaya Nagrajan Hegde, Anushanthy Balasingham, Rupshi Mitra
Rats are widely used animal models for biological psychiatry and neuroscience. Laboratory rats are typically housed in impoverished sensory environments. The lack of species-typical sensory environment might radically change the response of individual animals to stressful and/or threatening episodes. In this report, we demonstrate that behavioral and neural sequelae of chronic stress were modified by sensory environment of adult male rats. This includes effects of stress on the density of spines on CA3 hippocampal neurons, hippocampal neurogenesis and abundance of glucocorticoid or mineralocorticoid receptors...
February 1, 2018: Brain Research
https://www.readbyqxmd.com/read/29408274/running-exercise-mitigates-the-negative-consequences-of-chronic-stress-on-dorsal-hippocampal-long-term-potentiation-in-male-mice
#13
Roxanne M Miller, David Marriott, Jacob Trotter, Tyler Hammond, Dane Lyman, Timothy Call, Bethany Walker, Nathanael Christensen, Deson Haynie, Zoie Badura, Morgan Homan, Jeffrey G Edwards
In the hippocampus, learning and memory are likely mediated by synaptic plasticity, known as long-term potentiation (LTP). While chronic intermittent stress is negatively correlated, and exercise positively correlated to LTP induction, we examined whether exercise could mitigate the negative consequences of stress on LTP when co-occurring with stress. Mice were divided into four groups: sedentary no stress, exercise no stress, exercise with stress, and sedentary with stress. Field electrophysiology performed on brain slices confirmed that stress alone significantly reduced dorsal CA1 hippocampal LTP and exercise alone increased LTP compared to controls...
February 9, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29407214/impaired-glucocorticoid-mediated-hpa-axis-negative-feedback-induced-by-juvenile-social-isolation-in-male-rats
#14
Giorgia Boero, Maria Giuseppina Pisu, Francesca Biggio, Laura Muredda, Gianfranca Carta, Sebastiano Banni, Elena Paci, Paolo Follesa, Alessandra Concas, Patrizia Porcu, Mariangela Serra
We previously demonstrated that socially isolated rats at weaning showed a significant decrease in corticosterone and adrenocorticotropic hormone (ACTH) levels, associated with an enhanced response to acute stressful stimuli. Here we shown that social isolation decreased levels of total corticosterone and of its carrier corticosteroid-binding globulin, but did not influence the availability of the free active fraction of corticosterone, both under basal conditions and after acute stress exposure. Under basal conditions, social isolation increased the abundance of glucocorticoid receptors, while it decreased that of mineralocorticoid receptors...
January 31, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29403490/corticosterone-preexposure-increases-nf-%C3%AE%C2%BAb-translocation-and-sensitizes-il-1%C3%AE-responses-in-bv2-microglia-like-cells
#15
JiaJun Liu, Sanam Mustafa, Daniel Thomas Barratt, Mark Rowland Hutchinson
Corticosterone (CORT), a critical mediator of the hypothalamus pituitary adrenal axis in rodents, is a stress hormone that is classically viewed as possessing immune-suppressive properties. CORT is now appreciated to also mediate the neuroimmune-priming effect of stress to innate-immune stimulation, and hence serves as a mechanistic link to the neuroimmune involvement in stress-related disorders. However, these dichotomous actions of CORT remain poorly defined. This study investigated the conditions and concentration dependency of CORT's actions required to prime the innate-immune system...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29402648/treatment-of-cardiovascular-diseases-among-elderly-residents-of-long-term-care-facilities
#16
Anna Kańtoch, Barbara Gryglewska, Jadwiga Wójkowska-Mach, Piotr Heczko, Tomasz Grodzicki
BACKGROUND: The prevalence of cardiovascular diseases among nursing home residents is high but little is known whether pharmacologic therapy recommended by actual medication guidelines is followed by facility's staff. AIM: To evaluate the adherence to actual guidelines for treatment of cardiovascular diseases among older adult residents of long-term care (LTC) facilities. MATERIAL AND METHODS: The cross-sectional study was performed from December 2009 to November 2010 among 189 elderly residents aged ≥60 years in 3 LTC facilities in Poland: 1 long-term care hospital (LTCH) and 2 nursing homes (NHs)...
February 2, 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29402420/effect-of-optimization-of-medical-treatment-on-long-term-survival-of-patients-with-heart-failure-after-implantable-cardioverter-defibrillator-and-cardiac-resynchronization-device-implantation-from-the-french-national-egb-database
#17
Grégoire Massoullié, Chenaf Chouki, Aurélien Mulliez, Patrick Rossignol, Sylvain Ploux, Bruno Pereira, Adrien Reuillard, Fréderic Jean, Marius Andronache, Alain Eschalier, Pascal Motreff, Guillaume Clerfond, Pierre Bordachar, Nicolas Authier, Romain Eschalier
Prognosis of heart failure with reduced ejection fraction (HFrEF) is improved by drug optimization according to guidelines; however, little is known regarding such optimization in HFrEF patients with an implantable cardioverter defibrillator (ICD) or cardiac resynchronization therapy (CRT). This study aimed to describe implementation of this optimized strategy and its impact in patients implanted with an ICD/CRT. Using a 1/97th representative sample of the French national health-care insurance system claims database, a retrospective cohort study was conducted including HFrEF patients implanted with ICD or CRT between January 2009 and December 2014...
January 3, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29401591/the-glucocorticoid-antagonist-mifepristone-attenuates-sound-induced-long-term-deficits-in-auditory-nerve-response-and-central-auditory-processing-in-female-rats
#18
Wibke Singer, Kamyar Kasini, Marie Manthey, Philipp Eckert, Philipp Armbruster, Miriam Annika Vogt, Mirko Jaumann, Michela Dotta, Kohei Yamahara, Csaba Harasztosi, Ulrike Zimmermann, Marlies Knipper, Lukas Rüttiger
Systemic corticosteroids have been the mainstay of treatment for various hearing disorders for more than 30 yr. Accordingly, numerous studies have described glucocorticoids (GCs) and stressors to be protective in the auditory organ against damage associated with a variety of health conditions, including noise exposure. Conversely, stressors are also predictive risk factors for hearing disorders. How both of these contrasting stress actions are linked has remained elusive. Here, we demonstrate that higher corticosterone levels during acoustic trauma in female rats is highly correlated with a decline of auditory fiber responses in high-frequency cochlear regions, and that hearing thresholds and the outer hair cell functions (distortion products of otoacoustic emissions) are left unaffected...
January 12, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29401239/targeted-therapy-of-underlying-conditions-improves-sinus-rhythm-maintenance-in-patients-with-persistent-atrial-fibrillation-results-of-the-race-3-trial
#19
Michiel Rienstra, Anne H Hobbelt, Marco Alings, Jan G P Tijssen, Marcelle D Smit, Johan Brügemann, Bastiaan Geelhoed, Robert G Tieleman, Hans L Hillege, Raymond Tukkie, Dirk J Van Veldhuisen, Harry J G M Crijns, Isabelle C Van Gelder
Aims: Atrial fibrillation (AF) is a progressive disease. Targeted therapy of underlying conditions refers to interventions aiming to modify risk factors in order to prevent AF. We hypothesised that targeted therapy of underlying conditions improves sinus rhythm maintenance in patients with persistent AF. Methods and results: We randomized patients with early persistent AF and mild-to-moderate heart failure (HF) to targeted therapy of underlying conditions or conventional therapy...
February 1, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29400073/oral-hormonal-therapy-with-ethinylestradiol-levonorgestrel-improves-insulin-resistance-obesity-and-glycogen-synthase-kinase-3-independent-of-circulating-mineralocorticoid-in-estrogen-deficient-rats
#20
Oluwaseun Aremu Adeyanju, Olaniyi Soetan, Ayodele Soladoye, Lawrence A Aderemi Olatunji
Estrogen deficiency has been associated with increased cardiovascular diseases (CVD) and recent clinical trials of standard formulations of hormonal therapies have not demonstrated consistent beneficial effects. Estrogen-progestin therapy has been used as exogenous estrogen to normalise depressed estrogen level during menopause. Ovariectomized rodents mimic estrogen-deficient state in that they develop cardiometabolic dysfunction, including insulin resistance (IR).We therefore hypothesized that hormonal therapy with combined oral contraceptive steroids, ethinylestradiol/levonorgestrel (EEL) improves IR, obesity and glycogen synthase kinase-3 (GSK-3) through reduction in circulating mineralocorticoid level in ovariectomized rats...
February 3, 2018: Canadian Journal of Physiology and Pharmacology
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