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https://www.readbyqxmd.com/read/28336204/n-terminal-pro-brain-natriuretic-peptide-is-related-with-coronary-flow-velocity-reserve-and-diastolic-dysfunction-in-patients-with-asymmetric-hypertrophic-cardiomyopathy
#1
Milorad Tesic, Jelena Seferovic, Danijela Trifunovic, Ana Djordjevic-Dikic, Vojislav Giga, Ivana Jovanovic, Olga Petrovic, Jelena Marinkovic, Sanja Stankovic, Jelena Stepanovic, Arsen Ristic, Milan Petrovic, Nebojsa Mujovic, Bosiljka Vujisic-Tesic, Branko Beleslin, Vladan Vukcevic, Goran Stankovic, Petar Seferovic
BACKGROUND: The relations of elevated N-terminal pro-brain natriuretic peptide (NT-pro-BNP) and cardiac ischemia in hypertrophic cardiomyopathy (HCM) patients is uncertain. Therefore we designed the study with the following aims: (1) to analyze plasma concentrations of NT-pro-BNP in various subsets of HCM patients; (2) to reveal the correlations of NT-pro-BNP, myocardial ischemia, and diastolic dysfunction; (3) to assess predictors of the elevated plasma levels of NT-pro-BNP. METHODS AND RESULTS: In 61 patients (mean age 48...
March 20, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28327992/cyst-fluid-from-cystic-malignant-brain-tumors-a-reservoir-of-nutrients-including-growth-factor-like-nutrients-for-tumor-cells
#2
Daniel Dahlberg, Eduard A Struys, Erwin E Jansen, Lars Mørkrid, Øivind Midttun, Bjørnar Hassel
BACKGROUND: Brain tumors may have cysts, whose content of nutrients could influence tumor cell microenvironment and growth. OBJECTIVE: To measure nutrients in cyst fluid from glioblastoma multiforme (GBM) and metastatic brain tumors. METHODS: Quantification of nutrients in cyst fluid from 12 to 18 GBMs and 4 to 10 metastatic brain tumors. RESULTS: GBM cysts contained glucose at 2.2 mmol/L (median value; range <0.8-3...
January 25, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28325570/gender-differences-in-left-ventricular-ejection-fraction-and-outcomes-among-patients-hospitalized-for-acute-decompensated-heart-failure
#3
Katsuya Kajimoto, Yuichiro Minami, Naoki Sato, Shigeru Otsubo, Hiroshi Kasanuki
In patients with acute decompensated heart failure (HF), the association of gender and left ventricular ejection fraction (LVEF) with clinical outcomes has not been fully investigated. The aim of this study was to evaluate gender differences in LVEF and adverse outcomes across the full spectrum of LVEF in patients hospitalized for acute decompensated HF. Of the 4,842 patients enrolled in the Acute Decompensated Heart Failure Syndromes registry, 4,231 patients (2,461 men and 1,770 women) discharged alive after hospitalization for acute decompensated HF were investigated to assess the association of gender and LVEF with the primary end point (all-cause death and readmission for HF)...
March 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28323379/effects-of-short-term-levothyroxine-therapy-on-myocardial-injuries-in-patients-with-severe-overt-hypothyroidism-evidence-from-a-cardiac-mri-study
#4
Xia Gao, Zhe Chen, Min Liu, Yu-Mei Jia, Ning Yang, Zhi Yao, Xiao-Meng Feng, Yuan Xu, Guang Wang
PURPOSE: To investigate using magnetic resonance imaging (MRI) myocardial injuries and cardiac function in patients with newly diagnosed severe primary overt hypothyroidism (HT) before and after achieving euthyroidism by short-term levothyroxine treatment. Levothyroxine treatment improves cardiovascular performance and ventricular remodeling in patients with HT, but diffuse myocardial injuries induced by HT are difficult to detect clinically. MATERIALS AND METHODS: Myocardial longitudinal relaxation time (T1 ) mapping using the modified Look-Locker inversion-recovery (MOLLI) sequences at 3...
March 21, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28320747/association-of-cardiovascular-health-with-subclinical-disease-and-incident-events-the-multi-ethnic-study-of-atherosclerosis
#5
Tamar S Polonsky, Hongyan Ning, Martha L Daviglus, Kiang Liu, Gregory L Burke, Mary Cushman, John Eng, Aaron R Folsom, Pamela L Lutsey, Jennifer A Nettleton, Wendy S Post, Ralph L Sacco, Moyses Szklo, Donald M Lloyd-Jones
BACKGROUND: Few adults have ideal cardiovascular health (CVH). We studied associations of an overall CVH score with subclinical cardiovascular disease and events. We assessed whether associations varied by race/ethnicity. METHODS AND RESULTS: Among 5961 participants in the Multi-Ethnic Study of Atherosclerosis, components of CVH were measured at baseline, 2000-2002: systolic blood pressure, total cholesterol, fasting glucose, smoking, physical activity, diet, and body mass index...
March 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28320124/the-p-wave-terminal-force-in-embolic-strokes-of-undetermined-source
#6
Simona Lattanzi, Claudia Cagnetti, Alessandra Pulcini, Marco Morelli, Simone Maffei, Leandro Provinciali, Mauro Silvestrini
BACKGROUND: The Embolic Stroke of Undetermined Source (ESUS) is a recently developed clinical construct which describes stroke patients for whom the embolic source remains undetermined despite recommended investigations. The aim of the study was to characterize the ESUS population according to the abnormality in the P-wave terminal force in lead V1 (PTFV1). METHODS: We retrospectively identified consecutive patients hospitalized for acute ischemic stroke who met the ESUS diagnostic criteria...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28315504/association-of-triiodothyronine-levels-with-left-ventricular-function-cardiovascular-events-and-mortality-in-hemodialysis-patients
#7
Jianjun Gao, Yongxing Xu, Deyang Kong, Lei Zhou, Huaping Jia, Boran Liang, Zhaoyan Gu
BACKGROUND: Hemodialysis (HD) patients have altered free triiodothyronine (fT3) levels. A low fT3 level is a strong and inverse mortality predictor in HD patients. However, little is known about the relationship between fT3 and left ventricular function in HD patients. METHODS: A total of 128 maintenance HD patients were enrolled in this study. A thyroid function test with blood sampling and echocardiography was conducted. Low-T3 syndrome was defined as fT3 level <3...
March 16, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28302766/csf-clearance-in-alzheimer-disease-measured-with-dynamic-pet
#8
Mony J de Leon, Yi Li, Nobuyuki Okamura, Wai H Tsui, Les A Saint Louis, Lidia Glodzik, Ricardo S Osorio, Juan Fortea, Tracy Butler, Elizabeth Pirraglia, Silvia Fossati, Hee-Jin Kim, Roxana O Carare, Maiken Nedergaard, Helene Benveniste, Henry Rusinek
Evidence supporting the hypothesis that reduced cerebrospinal fluid (CSF) clearance is involved in the pathophysiology of Alzheimer's disease (AD) comes from primarily from rodent models. However, unlike rodents where predominant extra-cranial CSF egress is via olfactory nerves traversing the cribriform plate, human CSF clearance pathways are not well characterized. Using dynamic Positron Emission Tomography (PET) with (18)F-THK5117 a tracer for tau pathology, the ventricular CSF time activity was used as a biomarker for CSF clearance...
March 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28292861/assessment-of-diffuse-ventricular-myocardial-fibrosis-using-native-t1-in-children-with-repaired-tetralogy-of-fallot
#9
Deane Yim, Eugenie Riesenkampff, Pablo Caro-Dominguez, Shi-Joon Yoo, Mike Seed, Lars Grosse-Wortmann
BACKGROUND: Myocardial fibrosis is linked with adverse clinical outcomes in adults after tetralogy of Fallot repair (rTOF). Native T1 times (T1) by cardiac magnetic resonance have been shown to be a surrogate marker of diffuse myocardial fibrosis. The objective was to quantify native T1 in children post-rTOF and to evaluate their relationship with surgical, imaging, and clinical factors. METHODS AND RESULTS: A retrospective cross-sectional study was performed. Midventricular native T1 were obtained in 100 children post-rTOF using a modified look-locker inversion recovery cardiac magnetic resonance sequence and compared with 35 pediatric controls...
March 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28290816/-effects-of-amlodipine-lisinopril-fixed-dose-combination-on-severity-of-left-ventricular-hypertrophy-and-parameters-of-myocardial-stiffness-in-patients-with-hypertension
#10
O D Ostroumova, A I Kochetkov
AIM: To assess effects of 12 weeks treatment with the amlodipine/lisinopril fixed-dose combination (ALFDC) on the left ventricular (LV) mass index (LVMI), parameters of LV and left atrial stiffness. METHODS: At phase 1 of the study we examined 44 healthy subjects (21 men, 23 women, mean age 51.5+/-1.0 years) and 60 untreated patients (31 men, 29 women, mean age 53.6+/-0.8 years) with stage II grade 1-2hypertension. Myocardial stiffness parameters, LVMI were calculated using data of transthoracic echocardiography...
December 2016: Kardiologiia
https://www.readbyqxmd.com/read/28288987/plasma-and-cardiac-galectin-3-in-patients-with-heart-failure-reflects-both-inflammation-and-fibrosis-implications-for-its-use-as-a-biomarker
#11
Christian Besler, David Lang, Daniel Urban, Karl-Philipp Rommel, Maximilian von Roeder, Karl Fengler, Stephan Blazek, Reinhard Kandolf, Karin Klingel, Holger Thiele, Axel Linke, Gerhard Schuler, Volker Adams, Philipp Lurz
BACKGROUND: Galectin (Gal)-3 is a β-galactoside-binding lectin and currently intensely studied as a biomarker in heart failure. Gal-3 also exerts proinflammatory effects, at least in extracardiac tissues. Objective of this study was to characterize the relationship of plasma and myocardial Gal-3 levels with cardiac fibrosis and inflammation in patients with nonischemic dilated cardiomyopathy and inflammatory cardiomyopathy (iCMP). METHODS AND RESULTS: Endomyocardial biopsies and blood samples were obtained from patients with newly diagnosed cardiomyopathy and clinical suspicion of myocarditis...
March 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28288574/association-of-global-and-disease-specific-health-status-with-outcomes-following-continuous-flow-left-ventricular-assist-device-implantation
#12
Kelsey M Flint, John A Spertus, Fengming Tang, Philip Jones, Timothy J Fendler, Larry A Allen
BACKGROUND: The prognostic value of heart failure specific and global health status before and after left ventricular assist device (LVAD) implantation in the usual care setting is not well studied. METHODS: We included 3,836 continuous-flow LVAD patients in the INTERMACS registry. Health status was measured pre-operatively and 3 months post-LVAD using the Kansas City Cardiomyopathy Questionnaire (KCCQ) and EuroQol visual analog scale (VAS). Primary outcomes were mortality/rehospitalization...
March 14, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28288162/left-ventricular-long-axis-tissue-doppler-systolic-velocity-is-independently-related-to-heart-rate-and-body-size
#13
Roger E Peverill, Bon Chou, Lesley Donelan
BACKGROUND: The physiological factors which affect left ventricular (LV) long-axis function are not fully defined. We investigated the relationships of resting heart rate and body size with the peak velocities and amplitudes of LV systolic and early diastolic long axis motion, and also with long-axis contraction duration. METHODS: Two groups of adults free of cardiac disease underwent pulsed-wave tissue Doppler imaging at the septal and lateral mitral annular borders...
2017: PloS One
https://www.readbyqxmd.com/read/28285972/tp-e-interval-and-tp-e-qt-ratio-in-patients-with-human-immunodeficiency-virus
#14
Sefa Ünal, Çağrı Yayla, Burak Açar, Ahmet G Ertem, Mehmet K Akboğa, Serkan Gökaslan, Mehmet A Erdöl, Meliha Ç Sönmezer, Esra Kaya Kiliç, Çiğdem Ataman Hatipoğlu, Sinan Aydoğdu, Ahmet Temizhan
Human Immunodeficiency Virus (HIV) infection and AIDS are known to cause cardiovascular diseases such as premature coronary artery disease, cardiomyopathy, and arrhythmias. Recently, Tp-e interval and Tp-e/QT ratio has been shown as a novel marker of ventricular repolarization. We aimed to evaluate the ventricular repolarization using Tp-e interval and Tp-e/QT ratio in patients with Human Immunodeficiency Virus (HIV) infection. Totally 48 patients with HIV and 60 control subjects were enrolled to the study...
March 9, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28285119/fitness-in-young-adulthood-and-long-term-cardiac-structure-and-function-the-cardia-study
#15
Ambarish Pandey, Norrina B Allen, Colby Ayers, Jared P Reis, Henrique T Moreira, Stephen Sidney, Jamal S Rana, David R Jacobs, Lisa S Chow, James A de Lemos, Mercedes Carnethon, Jarett D Berry
OBJECTIVES: This study sought to evaluate the association between early-life cardiorespiratory fitness (CRF) and measures of left ventricular (LV) structure and function in midlife. BACKGROUND: Low CRF in midlife is associated with a higher risk of heart failure. However, the unique contributions of early-life CRF toward measures of LV structure and function in middle age are not known. METHODS: CARDIA (Coronary Artery Risk Development in Young Adults) study participants with a baseline maximal treadmill test and an echocardiogram at year 25 were included...
March 5, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28274575/relation-of-myocardial-contrast-enhanced-t1-mapping-by-cardiac-magnetic-resonance-to-left-ventricular-reverse-remodeling-after-cardiac-resynchronization-therapy-in-patients-with-nonischemic-cardiomyopathy
#16
Ulas Höke, Mand J H Khidir, Rob J van der Geest, Martin J Schalij, Jeroen J Bax, Victoria Delgado, Nina Ajmone Marsan
Myocardial scar is known to be associated with limited left ventricular (LV) reverse remodeling after cardiac resynchronization therapy (CRT). However, the impact of diffuse myocardial interstitial fibrosis, as assessed with myocardial T1 mapping cardiac magnetic resonance (CMR), has not been studied in patients with CRT. Therefore, we aimed at evaluating the association between diffuse myocardial interstitial fibrosis, in nonischemic cardiomyopathy patients, and LV reverse remodeling after CRT. A total of 40 patients (61 ± 11 years) with nonischemic cardiomyopathy who underwent CMR before CRT implantation were included...
February 9, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28262302/contraction-timing-patterns-in-patients-treated-for%C3%A2-breast-cancer-before-and-after-anthracyclines%C3%A2-therapy
#17
Kai-Hung Cheng, Mark D Handschumacher, Bruna Morhy Borges Leal Assuncao, Igal A Sebag, Elkan F Halpern, Marielle Scherrer-Crosbie
BACKGROUND: During the development of heart failure (HF), the changes of contraction timing pattern and temporal heterogeneity of segmental contraction happen early and may precede both symptomatic HF and the decrease in left ventricular ejection fraction (LVEF). In patients treated with anthracyclines, both symptomatic HF and the decrease of LVEF are detected once significant myocardial injury has occurred. The aim of the current study was to investigate whether changes in the timing of contraction can be detected early after anthracyclines therapy...
March 2, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28258906/association-between-subclinical-left-ventricular-systolic-dysfunction-and-glycemic-control-in-asymptomatic-type-2-diabetic-patients-with-preserved-left-ventricular-function
#18
Giacomo Zoppini, Corinna Bergamini, Stefano Bonapace, Andrea Rossi, Maddalena Trombetta, Alessandro Mantovani, Anna Toffalini, Laura Lanzoni, Lorenzo Bertolini, Luciano Zenari, Enzo Bonora, Giovanni Targher
BACKGROUND: Type 2 diabetes is strongly associated with the occurrence of cardiovascular diseases, especially heart failure. Some studies have suggested that subclinical systolic dysfunction as assessed by tissue Doppler imaging (TDI) is already present in uncomplicated diabetic patients with normal left ventricular ejection fraction (LVEF). Considering the importance of this aspect, the aim of this cross-sectional study was to examine the relationship between glycated hemoglobin and mean s' wave velocity (a reliable measure of early LV systolic dysfunction) in a cohort of type 2 diabetic outpatients with preserved LVEF and without ischemic heart disease...
February 13, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28248864/association-of-total-cholesterol-and-hdl-c-levels-and-outcome-in-coronary-heart-disease-patients-with-heart-failure
#19
Qin Zhao, Jianfei Li, Jin Yang, Rongshan Li
The aim of the study was to evaluate associations of total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) levels with prognosis in coronary heart disease (CHD) patients with heart failure (HF).Patients who were angiographical-diagnosis of CHD and echocardiographical-diagnosis of left ventricular ejection fraction (LVEF) < 45% were enrolled. Baseline characteristics were collected and association of TC and HDL-C levels with rehospitalization for HF and all-cause mortality was assessed...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28247527/association-of-left-atrial-enlargement-with-ventricular-remodeling-in-hypertensive-chinese-elderly
#20
Jing Peng, Jari A Laukkanen, Qianping Zhao, Liping Wang, Xu Zhang, Gang Li
BACKGROUND: It is not well known whether left atrial (LA) enlargement is associated with left ventricular (LV) remodeling in Asian subjects with preserved LV ejection fraction (LVEF ≥50%). Therefore, we studied whether LA enlargement is related to ventricular remodeling in hypertensive Chinese elderly with preserved LVEF. METHODS: Data of 480 hypertensive Chinese elderly (age from 65 to 94 years) with LVEF ≥50% were consecutively included in the study. RESULTS: We observed a total of 248 patients (51...
March 1, 2017: Echocardiography
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