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https://www.readbyqxmd.com/read/28899431/the-role-of-perfusion-and-diffusion-mri-in-the-assessment-of-patients-affected-by-probable-idiopathic-normal-pressure-hydrocephalus-a-cohort-prospective-preliminary-study
#1
Francesco Tuniz, Maria Caterina Vescovi, Daniele Bagatto, Daniela Drigo, Maria Cristina De Colle, Marta Maieron, Miran Skrap
BACKGROUND: Invasive tests measuring resistance to cerebral spinal fluid (CSF) outflow and the effect of temporary drainage of CSF are used to select candidates affected by idiopathic normal pressure hydrocephalus (iNPH) for shunt surgery. Neither test, however, completely excludes patients from treatment. Perfusion and diffusion magnetic resonance imaging (MRI) are non-invasive techniques that might be of value in selecting patients for surgical treatment and understanding brain changes in iNPH patients...
September 12, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28898433/changes-in-parameters-of-right-ventricular-function-with-cardiac-resynchronization-therapy
#2
Abhishek Sharma, Carl J Lavie, Ajay Vallakati, Akash Garg, Sunny Goel, Jason Lazar, Gregg C Fonarow
BACKGROUND: Studies have shown that cardiac resynchronization therapy (CRT) significantly improves right ventricle (RV) size and function in patients with heart failure (HF). HYPOTHESIS: CRT does not lead to improvement in RV function independent of baseline clinical variables. METHODS: A systematic search of studies published between 1966 to August 31, 2015 was conducted using Pub Med, CINAHL, Cochrane CENTRAL and the Web of Science databases...
September 12, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28893516/interleukin-6-is-independently-associated-with-right-ventricular-function-in-pulmonary-arterial-hypertension
#3
Kurt W Prins, Stephen L Archer, Marc Pritzker, Lauren Rose, E Kenneth Weir, Alok Sharma, Thenappan Thenappan
BACKGROUND: An elevated serum level of interleukin-6 (IL-6) in pulmonary arterial hypertension (PAH) patients results in a greater symptom burden and increased mortality; however, the mechanisms underlying these observations remain unclear. Because both pre-clinical and clinical data associate elevated IL-6 levels with impaired cardiac function, we hypothesized that the adverse effects of IL-6 in PAH result, in part, from right ventricular (RV) dysfunction. METHODS: We analyzed the relationship between IL-6 and RV function in 40 patients with PAH identified in our institutional PAH registry...
September 1, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28888837/left-ventricular-device-implantation-impacts-on-hospitalisation-rates-length-of-stay-and-out-of-hospital-time
#4
Roslyn Prichard, Louise Kershaw, Stephen Goodall, Patricia Davidson, Phillip Newton, Frederick McNeil, Timothy Homer, Christopher Hayward
BACKGROUND: Widespread application of left ventricular assist devices (LVADs) in advanced heart failure, is limited by costs, and access to technical expertise. Hospitalisation drives both cost and inversely, quality of life - but cross institutional and pre-surgical inpatient length of stay data is missing in the Australian literature. We describe changes in hospitalisation rates, in the year before and after bridge to transplant LVAD therapy and preceding heart transplant (HTX). METHODS: Hospitalisation, Australian refined diagnosis group (ArDRG), and clinical data were assessed for 77/100 consecutive patients listed for heart transplant between July of 2009 and June of 2012...
July 18, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28888274/blood-pressure-reactivity-to-psychological-stress-is-associated-with-clinical-outcomes-in-patients-with-heart-failure
#5
Andrew Sherwood, LaBarron K Hill, James A Blumenthal, Kirkwood F Adams, Nicola J Paine, Gary G Koch, Christopher M O'Connor, Kristy S Johnson, Alan L Hinderliter
INTRODUCTION: Cardiovascular (CV) reactivity to psychological stress has been implicated in the development and exacerbation of cardiovascular disease (CVD). Although high CV reactivity traditionally is thought to convey greater risk of CVD, the relationship between reactivity and clinical outcomes is inconsistent and may depend on the patient population under investigation. The present study examined CV reactivity in patients with heart failure (HF) and its potential association with long-term clinical outcomes...
September 2017: American Heart Journal
https://www.readbyqxmd.com/read/28888273/multinational-and-multiethnic-variations-in-health-related-quality-of-life-in-patients-with-chronic-heart-failure
#6
Nancy Luo, Tiew-Hwa Katherine Teng, Wan Ting Tay, Inder S Anand, William E Kraus, Houng Bang Liew, Lieng Hsi Ling, Christopher M O'Connor, Ileana L Piña, A Mark Richards, Wataru Shimizu, David J Whellan, Jonathan Yap, Carolyn S P Lam, Robert J Mentz
BACKGROUND: Assessing health-related quality of life (HRQoL) in patients with heart failure (HF) is an important goal of clinical care and HF research. We sought to investigate ethnic differences in perceived HRQoL and its association with mortality among patients with HF and left ventricular ejection fraction ≤35%, controlling for demographic characteristics and HF severity. METHODS AND RESULTS: We compared 5697 chronic HF patients of Indian (26%), white (23%), Chinese (17%), Japanese/Koreans (12%), black (12%), and Malay (10%) ethnicities from the HF-ACTION and ASIAN-HF multinational studies using the Kansas City Cardiomyopathy Questionnaire (KCCQ; range 0-100; higher scores reflect better health status)...
September 2017: American Heart Journal
https://www.readbyqxmd.com/read/28884121/contrast-microsphere-destruction-by-a-continuous-flow-ventricular-assist-device-an-in-vitro-evaluation-using-a-mock-circulation-loop
#7
David G Platts, Nicole Bartnikowski, Shaun D Gregory, Gregory M Scalia, John F Fraser
OBJECTIVES: Transthoracic echocardiography (TTE) is fundamental in managing patients supported with ventricular assist devices (VAD). However imaging can be difficult in these patients. Contrast improves image quality but they are hydrodynamically fragile agents. The aim was to assess contrast concentration following passage through a VAD utilising a mock circulation loop (MCL). METHODS: Heartware continuous flow (CF) VAD was incorporated into a MCL. Definity® contrast was infused into the MCL with imaging before and after CF-VAD...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28882338/relationship-of-cardiorespiratory-fitness-and-adiposity-with-left-ventricular-strain-in-middle-age-adults-from-the-dallas-heart-study
#8
Ambarish Pandey, Bryan Park, Spencer Martens, Colby Ayers, Ian J Neeland, Mark J Haykowsky, Michael D Nelson, Satyam Sarma, Jarett D Berry
Low cardiorespiratory fitness (CRF) and obesity are significant risk factors for heart failure (HF). However, given the inverse association between CRF and obesity, the independent contributions of low CRF and adiposity toward HF risk are not well established. We evaluated the association of CRF and measures of adiposity with left ventricular (LV) peak systolic strain-a subclinical measure of LV dysfunction-among the Dallas Heart Study phase II participants without cardiovascular disease who had CRF estimated using a submaximal treadmill test and LV systolic circumferential strain assessment by tissue-tagged cardiac magnetic resonance imaging...
July 25, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28882231/hemodynamic-response-to-nitroprusside-in-patients-with-low-gradient-severe-aortic-stenosis-and-preserved-ejection-fraction
#9
James W Lloyd, Rick A Nishimura, Barry A Borlaug, Mackram F Eleid
BACKGROUND: Low-gradient severe aortic stenosis (LGSAS) with preserved ejection fraction (EF) is incompletely understood. The influence of arterial afterload and diastolic dysfunction on the hemodynamic presentation of LGSAS remains unknown. OBJECTIVES: The authors sought to determine the acute hemodynamic response to sodium nitroprusside in LGSAS with preserved EF. METHODS: Symptomatic patients with LGSAS and preserved EF underwent cardiac catheterization with comparison of hemodynamic measurements before and after nitroprusside...
September 12, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28874384/heart-failure-is-common-and-under-recognized-in-patients-with-arrhythmogenic-right-ventricular-cardiomyopathy-dysplasia
#10
Nisha A Gilotra, Aditya Bhonsale, Cynthia A James, Anneline S J Te Riele, Brittney Murray, Crystal Tichnell, Abhishek Sawant, Chin Siang Ong, Daniel P Judge, Stuart D Russell, Hugh Calkins, Ryan J Tedford
BACKGROUND: Heart failure (HF) prevalence in arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) varies depending on study cohort and is not well characterized. This study sought to determine prevalence and predictors of HF in ARVC/D. METHODS AND RESULTS: Clinical HF, defined as at least 1 HF sign or symptom, was retrospectively adjudicated for 289 patients meeting ARVC/D Task Force Criteria. HF was present in 142 patients (49%): 113 had isolated RV involvement and 29 had evidence of LV dysfunction...
September 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28874030/synergistic-effects-of-remote-perconditioning-with-terminal-blood-cardioplegia-in-an-in-vivo-piglet-model
#11
Takayuki Abe, Kiyozo Morita, Gen Shinohara, Kazuhiro Hashimoto, Masako Nishikawa
OBJECTIVES: This study tested the hypothesis that remote perconditioning offers effective and synergistic cardioprotection to terminal warm blood cardioplegia for prompt ventricular recovery after prolonged cardioplegic arrest in an in vivo piglet model. METHODS: Twenty-four piglets were subjected to 120 min of single-dose cardioplegic arrest and were divided into 4 groups according to the mode of reperfusion: control (simple aortic unclamp), remote perconditioning, terminal warm blood cardioplegia or remote perconditioning + terminal warm blood cardioplegia; remote perconditioning (4 cycles of 5-min ischaemia-reperfusion of the lower limb) was applied prior to aortic unclamping...
September 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28861630/an-integrated-inverse-model-experimental-approach-to-determine-soft-tissue-three-dimensional-constitutive-parameters-application-to-post-infarcted-myocardium
#12
Reza Avazmohammadi, David S Li, Thomas Leahy, Elizabeth Shih, João S Soares, Joseph H Gorman, Robert C Gorman, Michael S Sacks
Knowledge of the complete three-dimensional (3D) mechanical behavior of soft tissues is essential in understanding their pathophysiology and in developing novel therapies. Despite significant progress made in experimentation and modeling, a complete approach for the full characterization of soft tissue 3D behavior remains elusive. A major challenge is the complex architecture of soft tissues, such as myocardium, which endows them with strongly anisotropic and heterogeneous mechanical properties. Available experimental approaches for quantifying the 3D mechanical behavior of myocardium are limited to preselected planar biaxial and 3D cuboidal shear tests...
August 31, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28860731/egfrs-from-asian-modified-ckd-epi-and-chinese-modified-ckd-epi-equations-were-associated-better-with-hypertensive-target-organ-damage-in-the-community-dwelling-elderly-chinese-the-northern-shanghai-study
#13
Hongwei Ji, Han Zhang, Jing Xiong, Shikai Yu, Chen Chi, Bin Bai, Jue Li, Jacques Blacher, Yi Zhang, Yawei Xu
BACKGROUND: With increasing age, estimated glomerular filtration rate (eGFR) decline is a frequent manifestation and is strongly associated with other preclinical target organ damage (TOD). In literature, many equations exist in assessing patients' eGFR. However, these equations were mainly derived and validated in the population from Western countries, which equation should be used for risk stratification in the Chinese population remains unclear, as well as their comparison. Considering that TOD is a good marker for risk stratification in the elderly, in this analysis, we aimed to investigate whether the recent eGFR equations derived from Asian and Chinese are better associated with preclinical TOD than the other equations in elderly Chinese...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28860011/the-relationship-between-chronic-health-conditions-and-outcome-following-out-of-hospital-ventricular-fibrillation-cardiac-arrest
#14
Florence Dumas, Jennifer Blackwood, Lindsay White, Carol Fahrenbruch, Xavier Jouven, Alain Cariou, Thomas Rea
INTRODUCTION: The cumulative burden of chronic health conditions could contribute to out-of-hospital cardiac arrest (OHCA) physiology and response to attempted resuscitation. Yet little is known about how chronic health conditions influence prognosis. We evaluated the relationship between cumulative comorbidity and outcome following ventricular fibrillation OHCA using 3 different scales. METHODS: We performed a cohort investigation of persons >=18years who suffered non-traumatic OHCA and presented with ventricular fibrillation between January 1, 2007 and December 31, 2013 in a metropolitan emergency medical service (EMS) system...
August 30, 2017: Resuscitation
https://www.readbyqxmd.com/read/28859681/factors-affecting-affect-cardiovascular-health-in-indonesian-hiv-patients-beginning-art
#15
Birry Karim, Ika Praseya Wijaya, Rizky Rahmaniyah, Ibnu Ariyanto, Shelley Waters, Riwanti Estiasari, Patricia Price
BACKGROUND: We present a small longitudinal study of how demographic factors and persistent burdens of HIV and cytomegalovirus (CMV) influence cardiovascular health in young adults beginning ART in an inner-city clinic in Jakarta, Indonesia. METHODS: ART-naïve HIV patients [n = 67; aged 31 (19 to 48) years] were enrolled in the JakCCANDO Project. Echocardiography and carotid Doppler ultrasonography were performed before ART (V0) and after 3, 6, and 12 months (V3-12)...
August 31, 2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28859128/plasma-microvesicle-analysis-identifies-microrna-129-5p-as-a-biomarker-of-heart-failure-in-univentricular-heart-disease
#16
Sweta Ramachandran, Alexander Lowenthal, Carissa Ritner, Shiri Lowenthal, Harold S Bernstein
Biomarkers of heart failure in adults have been extensively studied. However, biomarkers to monitor the progression of heart failure in children with univentricular physiology are less well understood. We proposed that as mediators of diverse pathophysiology, miRNAs contained within circulating microvesicles could serve as biomarkers for the presence and progression of heart failure in univentricular patients. To test this, we studied the association of heart failure with elevations in specific miRNAs isolated from circulating microvesicles in a cohort of children with univentricular heart disease and heart failure...
2017: PloS One
https://www.readbyqxmd.com/read/28855597/dynamics-and-implications-of-circulating-anti-angiogenic-vegf-a165b-isoform-in-patients-with-st-elevation-myocardial-infarction
#17
Luisa Hueso, Cesar Rios-Navarro, Amparo Ruiz-Sauri, Francisco Javier Chorro, Julio Nunez, Maria Jesus Sanz, Vicente Bodi, Laura Piqueras
Angiogenesis is crucial to restore microvascular perfusion in the jeopardized myocardium in the weeks following reperfused ST-segment elevation myocardial infarction (STEMI). (VEGF)-A165b, an anti-angiogenic factor, has been identified as a regulator of vascularization; however, it has not been previously implicated in acute myocardial infarction. We sought to investigate the dynamics of circulating VEGF-A165b and its association with cardiac magnetic resonance-derived infarct size and left ventricular ejection fraction (LVEF)...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28853674/mr-imaging-based-multimodal-autoidentification-of-perivascular-spaces-mmaps-automated-morphologic-segmentation-of-enlarged-perivascular-spaces-at-clinical-field-strength
#18
Erin L Boespflug, Daniel L Schwartz, David Lahna, Jeffrey Pollock, Jeffrey J Iliff, Jeffrey A Kaye, William Rooney, Lisa C Silbert
Purpose To describe a fully automated segmentation method that yields object-based morphologic estimates of enlarged perivascular spaces (ePVSs) in clinical-field-strength (3.0-T) magnetic resonance (MR) imaging data. Materials and Methods In this HIPAA-compliant study, MR imaging data were obtained with a 3.0-T MR imager in research participants without dementia (mean age, 85.3 years; range, 70.4-101.2 years) who had given written informed consent. This method is built on (a) relative normalized white matter, ventricular and cortical signal intensities within T1-weighted, fluid-attenuated inversion recovery, T2-weighted, and proton density data and (b) morphologic (width, volume, linearity) characterization of each resultant cluster...
August 29, 2017: Radiology
https://www.readbyqxmd.com/read/28852203/presence-of-obesity-is-associated-with-lower-mortality-in-elderly-patients-with-implantable-cardioverter-defibrillator
#19
A Jahangir, M Mirza, M Shahreyar, T Mengesha, R Shearer, S Sultan, A Jahangir, I Choudhuri, V Nangia, A Dhala, A Bhatia, I Niazi, J Sra, A J Tajik
BACKGROUND: Higher body mass index (BMI) is associated with greater prevalence of cardiovascular risk factors, yet an inverse relationship between obesity and survival after cardiovascular events has been described. It is unclear whether a similar relationship exists for patients with implantable cardioverter defibrillators (ICD) at high risk for mortality. We aimed to assess the impact of BMI on mortality and cardiovascular hospitalization in patients with ICD. METHODS: Patients who underwent ICD implantation in 2010-2011 were divided into normal (<25 kg/m(2)), overweight (25-29...
August 30, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28847067/-prenatal-exposure-to-ambient-air-pollution-and-congenital-heart-disease-a-meta-analysis
#20
S S Li, R Zhang, X Lan, P F Qu, S N Dang, F Y Chen, H Yan
Objective: To explore the association between exposure to ambient air pollution during pregnancy and congenital heart disease so as to provide evidence for primary prevention of congenital heart disease. Methods: Epidemiologic studies on ambient air pollution and congenital heart diseases were reviewed. Summary risk estimates were calculated at high versus low exposure levels and risk per-unit-increase in continuous pollutant concentration. Meta-analysis was conducted with Stata 12.0 software. Results: A total of 20 articles in English were qualified for inclusion...
August 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
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