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https://www.readbyqxmd.com/read/29150159/diagnostic-performance-of-pulmonary-capacitance-at-rest-and-during-exercise-in-idiopathic-pulmonary-arterial-hypertension
#1
Pankaj Jain, Sriram Rao, Peter Macdonald, Eugene Kotlyar, Andrew Jabbour, Christopher Hayward, Anne Keogh
BACKGROUND: Reliable markers of early disease are needed in pulmonary arterial hypertension (PAH). As measures of the contribution of abnormal vascular compliance to overall vascular resistance, resting and exercise pulmonary capacitance-defined as the stroke volume divided by the change in pulmonary pulse pressure-may be sensitive markers of early disease. METHODS: We examined all patients in our pulmonary hypertension database with idiopathic PAH, who had undergone rest and exercise right heart catheterisation in one sitting...
November 8, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29146482/impaired-left-atrial-strain-as-a-predictor-of-new-onset-atrial-fibrillation-after-aortic-valve-replacement-independently-of-left-atrial-size
#2
Guilherme Pessoa-Amorim, Jennifer Mancio, Luís Vouga, José Ribeiro, Vasco Gama, Nuno Bettencourt, Ricardo Fontes-Carvalho
INTRODUCTION AND OBJECTIVES: Left atrial dysfunction in aortic stenosis may precede atrial enlargement and predict the occurrence of atrial fibrillation (AF). To test this hypothesis, we assessed left atrial function and determined its impact on the incidence of AF after aortic valve replacement. METHODS: A total of 149 severe aortic stenosis patients (74±8.6 years, 51% men) with no prior AF were assessed using speckle-tracking echocardiography. Left atrial function was evaluated using peak atrial longitudinal strain (PALS), peak atrial contraction strain (PACS), and phasic left atrial volumes...
November 13, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29142154/the-choroid-plexus-of-the-lateral-ventricle-as-the-origin-of-csf-pulsation-is-questionable
#3
Ken Takizawa, Mitsunori Matsumae, Naokazu Hayashi, Akihiro Hirayama, Fumiya Sano, Satoshi Yatsushiro, Kagayaki Kuroda
The advent of magnetic resonance imaging (MRI) enables noninvasive measurement of cerebrospinal fluid (CSF) motion, and new information about CSF motion has now been acquired. The driving force of the CSF has long been thought to be choroid plexus (CP) pulsation, but to investigate whether this phenomenon actually occurs, CSF motion was observed in the ventricular system and subarachnoid space using MRI. Eleven healthy volunteers, ranging in age from 23 to 58 years, participated in this study. The MRI sequences used were four-dimensional phase-contrast (4D-PC) and time-spatial labeling inversion pulse (t-SLIP)...
November 16, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/29131444/native-t1-reference-values-for-nonischemic-cardiomyopathies-and-populations-with-increased-cardiovascular-risk-a-systematic-review-and-meta-analysis
#4
REVIEW
Maaike van den Boomen, Riemer H J A Slart, Enzo V Hulleman, Rudi A J O Dierckx, Birgitta K Velthuis, Pim van der Harst, David E Sosnovik, Ronald J H Borra, Niek H J Prakken
BACKGROUND: Although cardiac MR and T1 mapping are increasingly used to diagnose diffuse fibrosis based cardiac diseases, studies reporting T1 values in healthy and diseased myocardium, particular in nonischemic cardiomyopathies (NICM) and populations with increased cardiovascular risk, seem contradictory. PURPOSE: To determine the range of native myocardial T1 value ranges in patients with NICM and populations with increased cardiovascular risk. STUDY TYPE: Systemic review and meta-analysis...
November 13, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29130772/assessment-of-left-ventricular-function-using-the-myocardial-performance-index-in-term-fetuses-that-develop-intrapartum-compromise
#5
Amal A Alsolai, Larissa N Bligh, Ristan M Greer, Alexander Gooi, Sailesh Kumar
OBJECTIVE: To investigate the relationship between the prelabour left ventricular myocardial Performance Index (LVMPI) and intrapartum fetal compromise (IFC) in low risk term pregnancies. METHODS: A blinded, prospective observational cohort study at the Mater Mother's Hospital, Brisbane, Australia. A cohort of 284 women with uncomplicated singleton pregnancies underwent fortnightly ultrasound from 36 weeks until delivery. The LVMPI was assessed by conventional Doppler ultrasound and correlated with intrapartum outcomes...
November 12, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29129394/angiotensin-ii-receptor-blockers-suppress-the-release-of-stromal-cell-derived-factor-1%C3%AE-from-infarcted-myocardium-in-patients-with-acute-myocardial-infarction
#6
Toru Yoshizaki, Manabu Uematsu, Jun-Ei Obata, Takamitsu Nakamura, Daisuke Fujioka, Kazuhiro Watanabe, Kazuto Nakamura, Kiyotaka Kugiyama
BACKGROUND: Although angiotensin II receptor blockers (ARBs) have been shown to have anti-inflammatory effects on infarcted myocardium in experimental models, little is known in humans. Stromal cell-derived factor-1α (SDF-1α), a pro-inflammatory chemokine, is released from infarcted tissue in patients with acute myocardial infarction (AMI). This study examined whether ARBs suppress SDF-1α production in the infarcted lesion in patients with AMI. METHODS: SDF-1α levels were measured by enzyme-linked immunosorbent assays in plasma obtained from the aortic root (AO) and the anterior interventricular vein (AIV) in 50 patients with an anterior AMI...
November 9, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29127648/serum-apolipoprotein-b-is-inversely-associated-with-eccentric-left-ventricular-hypertrophy-in-peritoneal-dialysis-patients
#7
Min Ye, Yanqiu Liu, Haoyu Wang, Na Tian, Wei Li, Wei He, Hong Lin, Rui Fan, Cuiling Li, Donghong Liu, Fengjuan Yao
OBJECTIVES: The study aimed to examine the relationship of serum apolipoprotein B level with left ventricular (LV) structural and functional characteristics, in particular, LV remodeling parameters in peritoneal dialysis (PD) patients. METHODS: A total of 182 patients with end-stage renal disease (ESRD) receiving PD were identified. Conventional echocardiography was performed for each patient, and echocardiographic characteristics were analyzed according to apo B quartile groups...
November 10, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29125447/multiple-echocardiography-abnormalities-associated-with-endoscopic-third-ventriculostomy-failure
#8
Ashish H Shah, George M Ibrahim, Jun Sasaki, John Ragheb, Sanjiv Bhatia, Toba N Niazi
OBJECTIVE Although endoscopic third ventriculostomy (ETV) with choroid plexus cauterization (CPC) has gained increasing prominence in the management of hydrocephalus caused by intraventricular hemorrhage of prematurity, the rates of long-term shunt independence remain low. Furthermore, limited evidence is available to identify infants who might benefit from the procedure. The authors tested the hypothesis that elevated venous pressure that results from comorbid cardiac disease might predispose patients to ETV/CPC failure and shunt dependence...
November 10, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29118892/apical-hypertrophic-cardiomyopathy-a-case-report
#9
Ashraf Abugroun, Fatima Ahmed, Daniel Vilchez, Lalita Turaga
Apical hypertrophic cardiomyopathy (ApHCM) is a rare variant of hypertrophic cardiomyopathy, characterized by a spade-like left ventricular cavity. A 58-year-old African-American female with past medical history of hypertension presented for evaluation of recurrent exertional chest tightness, palpitations and headache. Prior workup including multiple stress tests and angiogram was non-conclusive. Electrocardiogram (EKG) showed characteristic marked T-waves inversions in inferior leads and left ventriculography revealed left ventricle apical hypertrophy with spade like left ventricular cavity that was typical of Yamaguchi syndrome...
October 2017: Cardiology Research
https://www.readbyqxmd.com/read/29118305/association-of-age-at-menarche-with-left-ventricular-diastolic-dysfunction-in-middle-aged-women
#10
Seungho Ryu, Yoosoo Chang, Jeong Gyu Kang, Jidong Sung, Jang-Young Kim, Hyun-Suk Jung, Kyung Eun Yun, Chan-Won Kim, Juhee Cho, Min-Jung Kwon, Kye-Hyun Kim, Hocheol Shin, Ki-Chul Sung
BACKGROUND: There is sparse research on whether if early menarche is related to left ventricular (LV) diastolic dysfunction. The present study examined this relationship in Korean women.Methods and Results:In a cross-sectional study we analyzed the records of 18,910 Korean women (≥30 years) who underwent echocardiography as part of a comprehensive health examination. Age at menarche was assessed using standardized, self-administered questionnaires. Presence of LV diastolic dysfunction was determined from the echocardiographic findings...
November 9, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29117120/increased-serum-levels-of-fetal-tenascin-c-variants-in-patients-with-pulmonary-hypertension-novel-biomarkers-reflecting-vascular-remodeling-and-right-ventricular-dysfunction
#11
Ilonka Rohm, Katja Grün, Linda Marleen Müller, Daniel Kretzschmar, Michael Fritzenwanger, Atilla Yilmaz, Alexander Lauten, Christian Jung, P Christian Schulze, Alexander Berndt, Marcus Franz
Pulmonary vascular remodeling is a pathophysiological feature that common to all classes of pulmonary hypertension (PH) and right ventricular dysfunction, which is the major prognosis-limiting factor. Vascular, as well as cardiac tissue remodeling are associated with a re-expression of fetal variants of cellular adhesion proteins, including tenascin-C (Tn-C). We analyzed circulating levels of the fetal Tn-C splicing variants B⁺ and C⁺ Tn-C in serum of PH patients to evaluate their potential as novel biomarkers reflecting vascular remodeling and right ventricular dysfunction...
November 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29116137/cardiovascular-consequences-of-myocardial-bridging-a-meta-analysis-and-meta-regression
#12
Sorin Hostiuc, Mugurel Constantin Rusu, Mihaela Hostiuc, Ruxandra Irina Negoi, Ionuț Negoi
Myocardial bridging, a congenital abnormality in which a coronary artery tunnels through the myocardial fibres was usually considered a benign condition. Many studies suggested a potential hemodynamic significance of myocardial bridging and some, usually case reports, implied a possible correlation between it and various cardiovascular pathologies like acute myocardial infarction, ventricular rupture, life-threatening arrhythmias, hypertrophic cardiomyopathy, apical ballooning syndrome or sudden death. The main objective of this article is to evaluate whether myocardial bridging may be associated with significant cardiac effects or if it is strictly a benign anatomical variation...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29116020/assessment-of-safety-and-efficacy-of-mesenchymal-stromal-cell-therapy-in-preclinical-models-of-acute-myocardial-infarction-a-systematic-review-protocol
#13
Carly C Barron, Manoj M Lalu, Duncan J Stewart, Dean Fergusson, Homer Yang, David Moher, Peter Liu, David Mazer, P J Devereaux, Lauralyn McIntyre
BACKGROUND: Despite advances in treatment, acute myocardial infarction (MI) is still associated with significant morbidity and mortality, especially in patients with extensive damage and scar formation. Based on some promising preclinical studies, there is interest in the use of mesenchymal stromal cells (MSCs) to promote cardiac repair after acute MI. However, there is a need for a systematic review of this evidence to summarize the efficacy and safety of MSCs in preclinical models of MI...
November 7, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29112315/reverse-double-inversion-recovery-improving-motion-robustness-of-cardiac-t2-weighted-dark-blood-turbo-spin-echo-sequence
#14
Chenxi Hu, Steffen Huber, Syed R Latif, Guido Santacana-Laffitte, Hamid R Mojibian, Lauren A Baldassarre, Dana C Peters
BACKGROUND: Cardiac dark-blood turbo spin-echo (TSE) imaging is sensitive to through-plane motion, resulting in myocardial signal reduction. PURPOSE: To propose and validate reverse double inversion-recovery (RDIR)-a dark-blood preparation with improved motion robustness for the cardiac dark-blood TSE sequence. STUDY TYPE: Prospective. POPULATION: Healthy volunteers (n = 10) and patients (n = 20). FIELD STRENGTH: 1...
November 7, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29106765/relative-identifiability-of-anisotropic-properties-from-magnetic-resonance-elastography
#15
Renee Miller, Arunark Kolipaka, Martyn P Nash, Alistair A Young
Although magnetic resonance elastography (MRE) has been used to estimate isotropic stiffness in the heart, myocardium is known to have anisotropic properties. This study investigated the determinability of global transversely isotropic material parameters using MRE and finite-element modeling (FEM). A FEM-based material parameter identification method, using a displacement-matching objective function, was evaluated in a gel phantom and simulations of a left ventricular (LV) geometry with a histology-derived fiber field...
November 6, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29106524/cardiac-myocyte-%C3%AE-3-adrenergic-receptors-prevent-myocardial-fibrosis-by-modulating-oxidant-stress-dependent-paracrine-signaling
#16
Nerea Hermida, Lauriane Michel, Hrag Esfahani, Emilie Dubois-Deruy, Joanna Hammond, Caroline Bouzin, Andreas Markl, Henri Colin, Anne Van Steenbergen, Christophe De Meester, Christophe Beauloye, Sandrine Horman, Xiaoke Yin, Manuel Mayr, Jean-Luc Balligand
Aims: Human and mouse cardiac beta3-adrenergic receptors (beta3AR) exert antipathetic effects to those of beta1-2AR stimulation. We examined their role in modulating myocardial remodelling, particularly fibrosis in response to haemodynamic stress. Methods and results: Mice with cardiac myocyte-specific expression of beta3AR (ADRB3-tg) or tamoxifen-inducible homozygous deletion (c-Adrb3-ko, with loxP-targeted Adrb3) were submitted to transaortic constriction. A superfusion assay was used for proteomic analysis of paracrine mediators between beta3AR-expressing cardiac myocytes and cardiac fibroblasts cultured separately...
July 6, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29101164/mathematical-modeling-physiological-effects-of-the-overexpression-of-%C3%AE-2-adrenoceptors-in-mouse-ventricular-myocytes
#17
Kelvin Rozier, Vladimir E Bondarenko
Transgenic (TG) mice overexpressing β2-adrenergic receptors (β2-ARs) demonstrate enhanced myocardial function, which manifests in increased basal adenylyl cyclase activity, enhanced atrial contractility, and increased left ventricular function in vivo. To gain insights into the mechanisms of these effects, we developed a comprehensive mathematical model of the mouse ventricular myocyte overexpressing β2-ARs. We found that most of the β2-ARs are active in control conditions in TG mice. Simulations describe the dynamics of major signaling molecules in different subcellular compartments; increased basal adenylyl cyclase activity; modifications of action potential shape and duration; the effects on the L-type Ca(2+) current and [Ca(2+)]i transients upon stimulation of β2-ARs in control, after the application of pertussis toxin (PTX), upon stimulation with a specific β2-AR agonist zinterol, and upon stimulation with zinterol in the presence of PTX...
November 3, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29099830/disfunci%C3%A3-n-ventricular-subcl%C3%A3-nica-por-speckle-tracking-en-pacientes-adultos-con-coartaci%C3%A3-n-de-aorta
#18
Nilda Espinola-Zavaleta, José Carlos Rúan-Díaz, María Elena Soto, Nydia Ávila-Vanzzini, Guillermo Bracamontes-Castelo, Leonel Avendaño-Pérez
Objective: The aim of this study was to investigate the presence of early left ventricular (LV) systolic dysfunction in adult patients with aortic coarctation (AoCo) and systemic arterial hypertension (SAH) compared to systemic hypertensive patients without coarctation and healthy controls by speckle tracking. Methods: Sixty-one subjects were studied, who attended consecutively to external consultation. All were submitted to clinical history, resting electrocardiogram, conventional echocardiogram and with Speckle Tracking...
2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/29093735/myocardial-expression-of-ppar%C3%AE-and-exercise-capacity-in-patients-after-coronary-artery-bypass-surgery
#19
Izabela Wojtkowska, Tomasz A Bonda, Jadwiga Wolszakiewicz, Jerzy Osak, Andrzej Tysarowski, Katarzyna Seliga, Janusz A Siedlecki, Maria M Winnicka, Ryszard Piotrowicz, Janina Stępińska
Activation of PPARs may be involved in the development of heart failure (HF). We evaluated the relationship between expression of PPARγ in the myocardium during coronary artery bypass grafting (CABG) and exercise tolerance initially and during follow-up. 6-minute walking test was performed before CABG, after 1, 12, 24 months. Patients were divided into two groups (HF and non-HF) based on left ventricular ejection fraction and plasma proBNP level. After CABG, 67% of patients developed HF. The mean distance 1 month after CABG in HF was 397 ± 85 m versus 420 ± 93 m in non-HF...
2017: PPAR Research
https://www.readbyqxmd.com/read/29089830/qualitative-and-quantitative-comparison-of-contrast-enhanced-fluid-attenuated-inversion-recovery-magnetization-transfer-spin-echo-and-fat-saturation-t1-weighted-sequences-in-infectious-meningitis
#20
Rajiv Azad, Mohit Tayal, Sheenam Azad, Garima Sharma, Rajendra Kumar Srivastava
OBJECTIVE: To compare the contrast-enhanced fluid-attenuated inversion recovery (CE-FLAIR), the CE T1-weighted (CE-T1W) sequence with fat suppression (FS) and magnetization transfer (MT) for early detection and characterization of infectious meningitis. MATERIALS AND METHODS: Fifty patients and 10 control subjects were evaluated with the CE-FLAIR and the CE-T1W sequences with FS and MT. Qualitative assessment was done by two observers for presence and grading of abnormal leptomeningeal enhancement...
November 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
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