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https://www.readbyqxmd.com/read/27926777/a-prospective-multicenter-cohort-study-to-validate-a-simple-performance-status-based-survival-prediction-system-for-oncologists
#1
Takeshi Yamada, Tatsuya Morita, Isseki Maeda, Satoshi Inoue, Masayuki Ikenaga, Yoshihisa Matsumoto, Mika Baba, Ryuichi Sekine, Takashi Yamaguchi, Takeshi Hirohashi, Tsukasa Tajima, Ryohei Tatara, Hiroaki Watanabe, Hiroyuki Otani, Chizuko Takigawa, Yoshinobu Matsuda, Shigeki Ono, Taketoshi Ozawa, Ryo Yamamoto, Hideki Shishido, Naoki Yamamoto
BACKGROUND: Survival prediction systems such as the Palliative Prognostic Index (PPI), which includes the Palliative Performance Scale (PPS), are used to estimate survival for terminally ill patients. Oncologists are, however, less familiar with the PPS in comparison with the Eastern Cooperative Oncology Group (ECOG) performance status (PS). This study was designed to validate a simple survival prediction system for oncologists, the Performance Status-Based Palliative Prognostic Index (PS-PPI), which is a modified form of the PPI based on the ECOG PS...
December 7, 2016: Cancer
https://www.readbyqxmd.com/read/27923968/exploring-gender-differences-in-a-randomized-trial-of-weight-loss-maintenance
#2
Melissa M Crane, Robert W Jeffery, Nancy E Sherwood
The purpose of this study is to explore gender differences in reasons for losing weight, weight loss methods, and weight loss behaviors prior to and during a weight loss maintenance trial. This is a secondary analysis of data from a 24-month randomized controlled trial comparing Self-Directed or Guided phone-based weight loss maintenance interventions among adults who had intentionally lost ≥10% of their body weight in the year prior to enrollment. Participants reported their weight loss methods and reasons for recently losing weight at baseline...
December 5, 2016: American Journal of Men's Health
https://www.readbyqxmd.com/read/27923791/reduced-density-and-altered-regulation-of-rat-atrial-l-type-ca2-current-in-rat-heart-failure
#3
Richard C Bond, Simon M Bryant, Judy J Watson, Jules C Hancox, Clive H Orchard, Andrew F James
Atrial L-type Ca(2+) current (ICaL) downregulation in heart failure contributes to the pathogenesis of atrial fibrillation and is proposed to involve reduction in channel phosphorylation by PKA. The regulation of atrial ICaL was examined in heart failure. Anesthetized adult male Wistar rats underwent surgical coronary artery ligation (CAL, N=10) or equivalent sham-operation (Sham, N=12). Left atrial myocytes were isolated ~18 weeks post-surgery and whole-cell currents recorded (holding potential=-80 mV). ICaL activated by depolarizing pulses to voltages from -40 to +50 mV were normalized to cell capacitance and current density-voltage relations plotted...
December 6, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27923110/impact-of-oligonucleotide-structure-chemistry-and-delivery-method-on-in-vitro-cytotoxicity
#4
Maja M Janas, Yongfeng Jiang, Mark K Schlegel, Scott Waldron, Satya Kuchimanchi, Scott A Barros
Single-stranded (ss) 2'-fluoro (2'-F)-modified oligonucleotides (ONs) with a full phosphorothioate (PS) backbone have been reported to be cytotoxic and cause DNA double-strand breaks (DSBs) when transfected into HeLa cells. However, the molecular determinants of these effects have not been fully explored. In this study, we investigated the impact of ON structure, chemistry, delivery method, and cell type on in vitro cytotoxicity and DSBs. We found that ss PS-ONs were more cytotoxic than double-stranded (ds) PS-ONs, irrespective of the 2'-ribose chemistry, inclusive of the 2'-F modification...
December 6, 2016: Nucleic Acid Therapeutics
https://www.readbyqxmd.com/read/27922935/enhancing-memory-self-efficacy-during-menopause-through-a-group-memory-strategies-program
#5
Anne E Unkenstein, Bei Bei, Christina A Bryant
OBJECTIVE: Anxiety about memory during menopause can affect quality of life. We aimed to improve memory self-efficacy during menopause using a group memory strategies program. METHODS: The program was run five times for a total of 32 peri- and postmenopausal women, age between 47 and 60 years, recruited from hospital menopause and gynecology clinics. The 4-week intervention consisted of weekly 2-hour sessions, and covered how memory works, memory changes related to ageing, health and lifestyle factors, and specific memory strategies...
December 5, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27922077/mast-cell-phenotype-tnf%C3%AE-expression-and-degranulation-status-in-non-small-cell-lung-cancer
#6
A Shikotra, C M Ohri, R H Green, D A Waller, P Bradding
Mast cell infiltration of tumour islets represents a survival advantage in non-small cell lung cancer (NSCLC). The phenotype and activation status of these mast cells is unknown. We investigated the mast cell phenotype in terms of protease content (tryptase-only [MCT], tryptase + chymase [MCTC]) and tumour necrosis factor-alpha (TNFα) expression, and extent of degranulation, in NSCLC tumour stroma and islets. Surgically resected tumours from 24 patients with extended survival (ES; mean survival 86.5 months) were compared with 25 patients with poor survival (PS; mean survival 8...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27922062/enhanced-self-organized-dewetting-of-ultrathin-polymer-blend-film-for-large-area-fabrication-of-sers-substrate
#7
Huanhuan Zhang, Lin Xu, Yabo Xu, Gang Huang, Xueyu Zhao, Yuqing Lai, Tongfei Shi
We study the enhanced dewetting of ultrathin Polystyrene (PS)/Poly (methyl methacrylate) (PMMA) blend films in a mixed solution, and reveal the dewetting can act as a simple and effective method to fabricate large-area surface-enhanced Raman scattering (SERS) substrate. A bilayer structure consisting of under PMMA layer and upper PS layer forms due to vertical phase separation of immiscible PS/PMMA during the spin-coating process. The thicker layer of the bilayer structure dominates the dewetting structures of PS/PMMA blend films...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27921225/dimensional-changes-in-the-kolahoi-glacier-from-1857-to-2014
#8
Aparna Shukla, Iram Ali, Nazia Hasan, Shakil A Romshoo
This study assimilates data from historical records (1857-1961/84), survey of India topographic maps, and a series of multispectral satellite data (1962-2014) for analyzing the shrinkage and dimensional changes of the Kolahoi glacier, Jammu and Kashmir, between 1857 and 2014. The composite results show that the glacier has receded by ∼3423 m (21.8 m/year) in the past 157 years. The historical records reveal that the glacier retreated by >1609 m from 1857 to 1909, 800 m from 1912 to 1961, and 210 m from 1961 to 1984...
December 2016: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/27921107/hollow-carbon-nanospheres-using-an-asymmetric-triblock-copolymer-structure-directing-agent
#9
Yunqi Li, Haibo Tan, Rahul R Salunkhe, Jing Tang, Lok Kumar Shrestha, Bishnu Prasad Bastakoti, Hongpan Rong, Toshiaki Takei, Joel Henzie, Yusuke Yamauchi, Katsuhiko Ariga
We introduce a simple method to prepare hollow carbon nanospheres (HCNs) by using triblock copolymer poly(styrene-b-2-vinylpyridine-b-ethylene oxide) (PS-b-P2VP-b-PEO) micelles as a new class of soft-templates. Simply by changing the solvent we can prepare ultra-small sized micelles of the triblock copolymer PS-b-P2VP-b-PEO soft template to obtain HCNs with ultra-small diameters (43 nm) and hollow cores (19 nm). Furthermore, we use these HCNs to make electric double-layer capacitors (EDLCs) that exhibit superior performance...
December 6, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27921074/initial-performance-studies-of-a-wearable-brain-positron-emission-tomography-camera-based-on-autonomous-thin-film-digital-geiger-avalanche-photodiode-arrays
#10
Charles R Schmidtlein, James N Turner, Michael O Thompson, Krishna C Mandal, Ida Häggström, Jiahan Zhang, John L Humm, David H Feiglin, Andrzej Krol
Using analytical and Monte Carlo modeling, we explored performance of a lightweight wearable helmet-shaped brain positron emission tomography (PET), or BET camera, based on thin-film digital Geiger avalanche photodiode arrays with Lutetium-yttrium oxyorthosilicate (LYSO) or [Formula: see text] scintillators for imaging in vivo human brain function of freely moving and acting subjects. We investigated a spherical cap BET and cylindrical brain PET (CYL) geometries with 250-mm diameter. We also considered a clinical whole-body (WB) LYSO PET/CT scanner...
January 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/27921069/reaching-200-ps-timing-resolution-in-a-time-of-flight-and-depth-of-interaction-positron-emission-tomography-detector-using-phosphor-coated-crystals-and-high-density-silicon-photomultipliers
#11
Sun Il Kwon, Alessandro Ferri, Alberto Gola, Eric Berg, Claudio Piemonte, Simon R Cherry, Emilie Roncali
Current research in the field of positron emission tomography (PET) focuses on improving the sensitivity of the scanner with thicker detectors, extended axial field-of-view, and time-of-flight (TOF) capability. These create the need for depth-of-interaction (DOI) encoding to correct parallax errors. We have proposed a method to encode DOI using phosphor-coated crystals. Our initial work using photomultiplier tubes (PMTs) demonstrated the possibilities of the proposed method, however, a major limitation of PMTs for this application is poor quantum efficiency in yellow light, corresponding to the wavelengths of the converted light by the phosphor coating...
October 2016: Journal of Medical Imaging
https://www.readbyqxmd.com/read/27921006/survival-and-control-prognosticators-of-recurrent-gynecological-malignancies-of-the-pelvis-and-para-aortic-region-treated-with-stereotactic-body-radiation-therapy
#12
Shaakir Hasan, Anthony Ricco, Kaylette Jenkins, Rachelle Lanciano, Alexandra Hanlon, John Lamond, Jun Yang, Jing Feng, Michael Good, Joel Noumoff, Luther Brady
PURPOSE: To define prognostic factors associated with improved survival and local control (LC) for gynecologic cancer recurrences limited to the pelvis and para-aortic (PA) region using stereotactic body radiation therapy (SBRT). METHODS: Between 2/2008 and 7/2014, 30 women (35 targets) with pelvic or PA recurrence of endometrioid (n = 12), cervical (n = 11), ovarian (n = 3), uterine-serous (n = 2), or carcinosarcoma (n = 2) cancer were treated with SBRT...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27919850/detection-and-differentiation-of-early-hepatocellular-carcinoma-from-cirrhosis-using-ct-perfusion-in-a-rat-liver-model
#13
Jin-Ping Li, Guang-Long Feng, Da-Qing Li, Hai-Bo Wang, De-Li Zhao, Yong Wan, Hui-Jie Jiang
BACKGROUND: Functional imaging such as CT perfusion can detect morphological and hemodynamic changes in hepatocellular carcinoma (HCC). Pre-carcinoma and early HCC nodules are difficult to differentiate by observing only their hemodynamics changes. The present study aimed to investigate hemodynamic parameters and evaluate their differential diagnostic cut-off between pre-carcinoma and early HCC nodules using CT perfusion and receiver operating characteristic (ROC) curves. METHODS: Male Wistar rats were randomly divided into control (n=20) and experimental (n=70) groups...
December 2016: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/27919685/programmed-cell-clearance-from-nematodes-to-humans
#14
Katharina Klöditz, Yu-Zen Chen, Ding Xue, Bengt Fadeel
Programmed cell clearance is a highly regulated physiological process of elimination of dying cells that occurs rapidly and efficiently in healthy organisms. It thus ensures proper development as well as homeostasis. Recent studies have disclosed a considerable degree of conservation of cell clearance pathways between nematodes and higher organisms. The externalization of the anionic phospholipid phosphatidylserine (PS) has emerged as an important "eat-me" signal for phagocytes and its exposition on apoptotic cells is controlled by phospholipid translocases and scramblases...
December 2, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27919497/comparative-efficacy-and-discontinuation-of-dimethyl-fumarate-and-fingolimod-in-clinical-practice-at-12-month-follow-up
#15
Carrie M Hersh, Thomas E Love, Samuel Cohn, Claire Hara-Cleaver, Robert A Bermel, Robert J Fox, Jeffrey A Cohen, Daniel Ontaneda
BACKGROUND: Dimethyl fumarate (DMF) and fingolimod (FTY) are approved oral disease modifying therapies (DMT) for relapsing multiple sclerosis (MS). Phase 3 trials established these agents as effective and generally well tolerated, though comparative efficacy and discontinuation remain unknown. OBJECTIVE: To assess real-world efficacy and discontinuation of DMF and FTY over 12 months in patients with MS. METHODS: We identified 458 DMF-treated and 317 FTY-treated patients in a large academic MS center...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27918492/xanthines-studied-via-femtosecond-fluorescence-spectroscopy
#16
Pascale Changenet-Barret, Lajos Kovács, Dimitra Markovitsi, Thomas Gustavsson
Xanthines represent a wide class of compounds closely related to the DNA bases adenine and guanine. Ubiquitous in the human body, they are capable of replacing natural bases in double helices and give rise to four-stranded structures. Although the use of their fluorescence for analytical purposes was proposed, their fluorescence properties have not been properly characterized so far. The present paper reports the first fluorescence study of xanthine solutions relying on femtosecond spectroscopy. Initially, we focus on 3-methylxanthine, showing that this compound exhibits non-exponential fluorescence decays with no significant dependence on the emission wavelength...
December 3, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27918337/the-effects-of-a-genital-vibratory-stimulation-device-on-sexual-function-and-genital-sensation
#17
Marsha K Guess, Kathleen A Connell, Scott Chudnoff, Olusola Adekoya, Cherrilyn Richmond, Kayla E Nixon, Katherine Freeman, Arnold Melman
OBJECTIVE: The aim of this study was to evaluate the effectiveness of a genital vibratory stimulation device in improving sexual function in women with arousal and orgasm disorders. METHODS: In this single-arm, prospective study, baseline and 1- and 3-month assessments were performed to evaluate women with sexual arousal and/or orgasmic disorders, who received therapy using a genital vibratory stimulation device. Sexual function, satisfaction, and distress were evaluated using the Female Sexual Function Index (FSFI), the Female Sexual Distress Scale, and the Female Intervention Efficacy Index questionnaires...
December 1, 2016: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/27918331/growth-of-nonoperating-room-anesthesia-care-in-the-united-states-a-contemporary-trends-analysis
#18
Alexander Nagrebetsky, Rodney A Gabriel, Richard P Dutton, Richard D Urman
BACKGROUND: Although previous publications suggest an increasing demand and volume of nonoperating room anesthesia (NORA) cases in the United States, there is little factual information on either volume or characteristics of NORA cases at a national level. Our goal was to assess the available data using the National Anesthesia Clinical Outcomes Registry (NACOR). METHODS: We performed a retrospective analysis of NORA volume and case characteristics using NACOR data for the period 2010-2014...
December 1, 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27918104/quality-of-life-following-trauma-before-and-after-implementation-of-a-physician-staffed-helicopter
#19
K S Funder, L S Rasmussen, R Hesselfeldt, V Siersma, N Lohse, A Sonne, S Wulffeld, J Steinmetz
BACKGROUND: Implementation of a physician-staffed helicopter emergency medical service (PS-HEMS) in Denmark was associated with lower 30-day mortality in severely injured trauma patients and less time on social subsidy. However, the reduced 30-day mortality in severely injured patients might be at the expense of a worse functional outcome and quality of life (QoL) in those who survive. The aim of this study was to investigate the effect of a physician-staffed helicopter on long-term QoL in trauma patients...
January 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/27917862/purslane-portulaca-oleracea-seed-consumption-and-aerobic-training-improves-biomarkers-associated-with-atherosclerosis-in-women-with-type-2-diabetes-t2d
#20
Firouzeh Dehghan, Rahman Soori, Khadijeh Gholami, Mitra Abolmaesoomi, Ashril Yusof, Sekaran Muniandy, Sara Heidarzadeh, Parvin Farzanegi, Mohammad Ali Azarbayjani
The aim of this study was to investigate the responses of atherosclerosis plaque biomarkers to purslane seed consumption and aerobic training in women with T2D. 196 women with T2D were assigned into; (1) placebo (PL), (2) aerobic training+placebo (AT + PL), 3) purslane seeds (PS), aerobic training+purslane seeds (AT + PS). The training program and purslane seeds consumption (2.5 g lunch and 5 g dinner) were carried out for 16 weeks. The components of purslane seed were identified and quantified by GC-MS...
December 5, 2016: Scientific Reports
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