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Shipra Arya, Anjali Khakharia, Zachary O Binney, Randall R DeMartino, Luke P Brewster, Philip P Goodney, Peter W F Wilson
Background -Statin dose guidelines for Peripheral Artery Disease (PAD) patients are largely based on coronary artery disease and stroke data. The aim of this study is to determine the effect of statin intensity on PAD outcomes of amputation and mortality. Methods -Using an observational cohort study design and a validated algorithm we identified incident PAD patients (2003-2014) in the national Veterans Affairs data. Highest statin intensity exposure [high intensity vs low- moderate intensity vs antiplatelet therapy but no statin use (AP only)] was determined within one year of diagnosis of PAD...
January 12, 2018: Circulation
Arya Haj-Mirzaian, Ali Guermazi, Frank W Roemer, Mike A Bowes, Philip G Conaghan, Shadpour Demehri
OBJECTIVE: To determine the association between bisphosphonate treatment with the change of periarticular bone area and three-dimensional (3D) shape in participants of the Osteoarthritis Initiative (OAI) study. DESIGN: Using propensity score (PS) matching method in females, 48 bisphosphonate users and 105 non-users, who were matched for OA and osteoporosis related factors were included. Baseline and 24-month MRI-based periarticular bone area and 3D shape measurements were used...
January 9, 2018: Osteoarthritis and Cartilage
Leslie R Harrold, Heather J Litman, Katherine C Saunders, Kimberly J Dandreo, Bernice Gershenson, Jeffrey D Greenberg, Robert Low, Jeffrey Stark, Robert Suruki, Srihari Jaganathan, Joel M Kremer, Mohamed Yassine
BACKGROUND: Registry studies provide a valuable source of comparative safety data for tumor necrosis factor inhibitors (TNFi) used in rheumatoid arthritis (RA), but they are subject to channeling bias. Comparing safety outcomes without accounting for channeling bias can lead to inaccurate comparisons between TNFi prescribed at different stages of the disease. In the present study, we examined the incidence of serious infection and other adverse events during certolizumab pegol (CZP) use vs other TNFi in a U...
January 2, 2018: Arthritis Research & Therapy
Molly M Crenshaw, Cara G Goerlich, Lauren E Ivey, Julie C Sapp, Kim M Keppler-Noreuil, Allison C Scott, Leslie G Biesecker, Laura L Tosi
INTRODUCTION: Proteus syndrome (PS) is a rare mosaic disorder comprising asymmetric bony and soft tissue overgrowth leading to significant morbidity. Placement of growth inhibition hardware with subsequent epiphyseal arrest improves leg-length and angular deformities in pediatric patients without PS. The purpose of this study was to review the surgical approach and present outcomes, complications, and recommendations in 8 patients with PS and leg-length discrepancy (LLD). METHODS: We conducted a retrospective chart review of 8 patients with PS whose primary reason for surgery was LLD...
January 11, 2018: Journal of Pediatric Orthopedics
J Zopes, K Sasaki, K S Cujia, J M Boss, K Chang, T F Segawa, K M Itoh, C L Degen
We investigate the application of amplitude-shaped control pulses for enhancing the time and frequency resolution of multipulse quantum sensing sequences. Using the electronic spin of a single nitrogen-vacancy center in diamond and up to 10 000 coherent microwave pulses with a cosine square envelope, we demonstrate 0.6-ps timing resolution for the interpulse delay. This represents a refinement by over 3 orders of magnitude compared to the 2-ns hardware sampling. We apply the method for the detection of external ac magnetic fields and nuclear magnetic resonance signals of ^{13}C spins with high spectral resolution...
December 29, 2017: Physical Review Letters
Zia Ur Rahman, Ning Wei, Yange Feng, Xiaolong Zhang, Daoai Wang
A facile method was used to prepare hollow mesoporous TiO2 and Au@TiO2 spheres using polystyrene (PS) templates. Au nanoparticles (NPs) were simultaneously synthesized and attached on the surface of PS spheres by reducing AuCl4- ions using sodium citrate which resulted in the uniform deposition of Au NPs. The outer coating of titania via sol-gel produced PS@Au@TiO2 core-shell spheres. Removing the templates from these core-shell spheres through calcination produced hollow mesoporous and crystalline Au@TiO2 spheres with Au NPs inside the TiO2 shell in a single step...
January 12, 2018: Chemistry, An Asian Journal
So Jung Park, Seyong Kim, Daeseong Yong, Youngson Choe, Joona Bang, Jaeup U Kim
We systematically examined the polymer-mediated interparticle interactions between polymer-grafted nanoparticles (NPs) within chemically identical homopolymer matrices through experimental and computational efforts. In experiments, we prepared thermally stable gold NPs grafted with polystyrene (PS) or poly(methyl methacrylate) (PMMA), and they were mixed with corresponding homopolymers. The nanocomposites are well dispersed when the molecular weight ratio of free to grafted polymers, α, is small. For α above 10, NPs are partially aggregated or clumped within the polymer matrix...
January 12, 2018: Soft Matter
Chenhui Xie, Zexin Chen, Songnian Fu, Wu Liu, Zhixue He, Lei Deng, Ming Tang, Deming Liu
We present the first experimental demonstration of orthogonal frequency division multiplexed (OFDM) modulation using the probabilistic shaping (PS) technique in visible light communication (VLC) systems, in order to increase the achievable information rate (AIR) according to the pre-estimated signal to noise ratio (SNR) of VLC channel. We numerically investigate the performance of PS technique and make a fair comparison with bit-loading technique under different scenarios. By using a phosphor-LED based VLC system with available bandwidth of ~45-MHz, OFDM with PS technique can experimentally realize an AIR of 204...
January 8, 2018: Optics Express
Nan Deng, Zhangweiyi Liu, Xiaocheng Wang, Tiantian Fu, Weilin Xie, Yi Dong
We report a long-distance phase-stabilized millimeter-wave distribution over optical fibers, where the optical-link-induced phase noise is compensated with a high-precision photonic-generated millimeter-wave (mm-wave) voltage-controlled oscillator (VCO). The mm-wave VCO is realized based on pre-filtering and re-modulating optical spectral lines of an optical frequency comb (OFC). By adjusting the frequency spacing of the optical spectral lines extracted from the OFC, the phase error of the transmitted optical mm-wave signal can be compensated precisely...
January 8, 2018: Optics Express
Hengyun Jiang, Lianshan Yan, Wei Pan, Bing Luo, Xihua Zou
Radio frequency (RF) filtering switch is highly desired for signal routing or manipulation in the RF system. Based on the stimulated Brillouin scattering effect and the electro-optics Pockels effect, we propose a novel RF filtering switch with a high-frequency filtering precision and a fast switching speed. We have experimentally demonstrated the RF filtering with a high precision of ∼34  MHz, a wide operation bandwidth of ∼18  GHz, and the RF switching at a speed of <100  ps, which is hundreds of times faster than the traditional RF switch...
January 15, 2018: Optics Letters
Junqing Zhao, Lei Li, Luming Zhao, Dingyuan Tang, Deyuan Shen
We report on a type of 2 μm h-shaped pulse generation in a thulium-holmium-doped fiber laser and experimentally investigate its cavity birefringence and pump power dependences. An asymmetric nonlinear optical loop mirror is employed as an artificial saturable absorber, which incorporates ∼52.7  m dispersion-shifted fiber and ∼3.8  m ultra-high numerical aperture fiber to enhance the nonlinearity. The h-shaped pulse shows both a polarization state (PS) and pump power related evolutions, even when randomly weak birefringence fibers are employed...
January 15, 2018: Optics Letters
Jun Zhang, Hao Ouyang, Xin Zheng, Jie You, Runze Chen, Tong Zhou, Yizhen Sui, Yu Liu, Xiang'ai Cheng, Tian Jiang
The newly raised two-dimensional material MoS2 is regarded as an ideal candidate for saturated absorbers. Here, the open-aperture Z-scan method is used to study the saturation absorption (SA) response of monolayer and multilayer MoS2, considering laser irradiation with different pulse widths. Specifically, in cases of 10 ns and 10 ps laser pulses, the accumulative nonlinearity [e.g., free carrier absorption (FCA)] coupled with SA is found in both monolayer and multilayer MoS2. However, under a 65 fs pulse laser, the instantaneous nonlinearity [e...
January 15, 2018: Optics Letters
Yan Zheng, Jilong Li, Yitang Dai, Feifei Yin, Kun Xu
We demonstrate a novel real-time Fourier transformation scheme with megahertz-level resolution realized by bandwidth magnification of radio frequency (RF) signals. Before the frequency-to-time mapping, the RF signal is modulated on an optical frequency comb, and then extracted by a Vernier comb filter. As a result, RF components can be separated in the spectrum with a greatly magnified optical bandwidth. Thus, even with limited dispersion provided by an ordinary optical fiber, the frequency-dependent pulses can be distinguished in the time domain...
January 15, 2018: Optics Letters
Sisi Tan, Xiaoming Wei, Jianglai Wu, Lingxiao Yang, Kevin K Tsia, Kenneth K Y Wong
Dispersive pulse-stretching at 2.0 μm has long been hindered by the high intrinsic optical loss from conventional dispersive media. Here a flexible pulse-stretching technique at 2.0 μm is demonstrated over a broad bandwidth with large-scale dispersion and low intrinsic optical loss. The technique employs the newly proposed pulse-stretching scheme, namely, free-space angular-chirp-enhanced delay. Both normal and anomalous temporal dispersion (up to ±500  ps/nm) with low intrinsic loss (<6  dB) over a spectral bandwidth of ∼84  nm at 2...
January 1, 2018: Optics Letters
Hee Jung Ryu, Jiyong Hwang, Jongyoon Kim, Ji-Hoon Lee
We investigated the dependence of the birefringence of polystyrene (PS) film with a negative optical birefringence on the stretching conditions. We varied the stretching ratio (SR), stretching speed (SS), and stretching temperature (ST), and measured the inplane birefringence and the Nz coefficient of the PS film. The inplane birefringence was increased with greater SR and SS but decreased with greater ST. The Nz coefficient of the stretched PS film was around zero and showed similar dependence on the stretching conditions like inplane birefringence...
January 10, 2018: Applied Optics
Akihisa Miayagawa, Makoto Harada, Tetsuo Okada
We present a novel analytical principle in which an analyte (according to its concentration) induces a change in the density of a microparticle, which is measured as a vertical coordinate in a coupled acoustic-gravitational (CAG) field. The density change is caused by the binding of gold nanoparticles (AuNPs) on a polystyrene (PS) microparticle through avidin-biotin association. The density of a 10-m PS particle increases by 2 % when 500 100-nm AuNPs are bound to the PS. The CAG can detect this density change as a 5-10-m shift of the levitation coordinate of the PS...
January 12, 2018: Analytical Chemistry
Rong Wu, Gao-Chao Fan, Li-Ping Jiang, Jun-Jie Zhu
The ability to rapidly detect apoptotic cells and accurately evaluate therapeutic effects is significant in cancer research. To address this target, a biocompatible, ultrasensitive photoelectrochemical (PEC) cytosensing platform was developed based on electrochemically reduced graphene (EG)/ZnIn2S4 co-sensitized TiO2 coupled with specific recognition between apoptotic cells and phosphatidylserine (PS)-binding peptide (PSBP). In this strategy, HL-60 cells were selected as a model, and C005, nilotinib and imatinib were selected as apoptosis inducers to show cytosensing performance...
January 12, 2018: ACS Applied Materials & Interfaces
Carlton F O Hoy, Keiichiro Kushiro, Madoka Takai
This study investigated the fabrication and proof of concept design demonstrating rapid and highly sensitive antigen capture utilizing electrospun polystyrene (PS) microfiber mat substrates paired with vacuum pump pressurization to induce bulk flow. In comparison with conventional flat PS surfaces used for immunoassay purposes, this system optimizes the increased surface area of the electrospun polystyrene (ESPS) fiber mat substrates and the accelerated propagation of the antigen through the detection platform by using a vacuum pump to enable efficient and rapid antigen capture...
January 12, 2018: Analyst
Wen Xiang Lim, Manukumara Manjappa, Yogesh Kumar Srivastava, Longqing Cong, Abhishek Kumar, Kevin F MacDonald, Ranjan Singh
Incorporating semiconductors as active media into metamaterials offers opportunities for a wide range of dynamically switchable/tunable, technologically relevant optical functionalities enabled by strong, resonant light-matter interactions within the semiconductor. Here, a germanium-thin-film-based flexible metaphotonic device for ultrafast optical switching of terahertz radiation is experimentally demonstrated. A resonant transmission modulation depth of 90% is achieved, with an ultrafast full recovery time of 17 ps...
January 12, 2018: Advanced Materials
Shinkichi Takamori, Gouji Toyokawa, Tatsuro Okamoto, Mototsugu Shimokawa, Fumihiko Kinoshita, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Takaki Akamine, Kazuki Takada, Masakazu Katsura, Fumihiko Hirai, Fumihiro Shoji, Tetsuzo Tagawa, Yoshinao Oda, Hiroshi Honda, Yoshihiko Maehara
BACKGROUND: A relationship between sarcopenia diagnosed by skeletal muscle area (SMA) and poor prognosis in cancer patients has recently been reported. This study aimed to clarify the clinical significance of postoperatively decreased SMA in patients with early non-small cell lung cancer (NSCLC). METHODS: This study selected 101 patients with pathologic stage 1 NSCLC who had undergone pre- and postoperative (~ 1 year) computed tomography scans and lobectomy between 2005 and 2010 at Kyushu University Hospital...
January 11, 2018: Annals of Surgical Oncology
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