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https://www.readbyqxmd.com/read/28072811/evaluation-of-the-ototoxicity-potential-of-once-daily-single-entity-hydrocodone-in-patients-with-chronic-pain-results-of-two-phase-3-clinical-studies
#1
Kathleen Campbell, J Walter Kutz, Angela Shoup, Warren Wen, Shau Yu Lynch, Ellie He, Steven R Ripa
BACKGROUND: Use/misuse of the opioid combination hydrocodone-acetaminophen has been associated with permanent hearing loss. Although reports have been rare, this potential effect can have significant detrimental effect on patients' overall quality of life. To date, the ototoxic effect of hydrocodone alone has not been systematically investigated. OBJECTIVE: In this report, we aimed to evaluate the potential ototoxicity of a novel, single-entity, once-daily, extended-release hydrocodone tablet (Hysingla® ER; HYD)...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28025523/development-of-a-uplc-tq-ms-approach-for-the-determination-of-eleven-bioactive-components-in-haizao-yuhu-decoction-plus-minus-haizao-and-gancao-drug-combination-after-oral-administration-in-a-rat-model-of-hypothyroidism
#2
Yingchang Ma, Yang Zhang, Yuanjuan Zhai, Zhenhua Zhu, Ying Pan, Dawei Qian, Shulan Su, Xinsheng Fan, Jinao Duan
Haizao Yuhu Decoction (HYD) has been used for approximately 500 years and is well-known in Traditional Chinese Medicine for its efficacy in the treatment of thyroid-related diseases. In this study, a rapid liquid chromatography-tandem mass spectrometry method was developed for the determination of liquiritin, naringin, hesperidin, peimine, liquiritigenin, glycyrrhizic acid, bergapten, nobiletin, osthole, and glycyrrhetinic acid in rat plasma to investigate the pharmacokinetic profile of different HYD prescriptions in a rat model of hypothyroidism...
December 22, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28018474/traditional-chinese-medicine-huannao-yicong-decoction-extract-decreases-tau-hyperphosphorylation-in-the-brain-of-alzheimer-s-disease-model-rats-induced-by-a%C3%AE-1-42
#3
Yu Cao, Xingxing Jia, Yun Wei, Meixia Liu, Jiangang Liu, Hao Li
Objective. Huannao Yicong Decoction (HYD, ) has been shown to improve the learning and memory capabilities of Alzheimer's disease (AD) subjects. However, the underlying mechanism remains to be determined. Methods. Sixty Sprague-Dawley rats were divided equally and randomly into five different groups including control, positive control, and HYD granules of low dose, medium dose, and high dose by daily gavage. The sham-treated rats were also given the same volume of sterile water by gavage. Twelve SD rats were treated with the same amount of physiological saline...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28012250/the-effect-of-ureaplasma-urealyticum-on-the-level-of-p34h-expression-the-activity-of-hyaluronidase-and-dna-fragmentation-in-human-spermatozoa
#4
Xiao-Ping Ma, Xiao-Qin Gao
BACKGROUND: To study the effect of Ureaplasma urealyticum on the level of P34H expression, the activity of hyaluronidase, and the DNA fragmentation in human spermatozoa. METHOD: Western blot was used to detect the level of P34H expression on spermatozoa.The localization of this protein on human spermatozoa was determined by indirect immunofluorescent and observed by laser scanning confocal microscope. The activity of hyaluronidase was examined by improved fixed-substrate film method...
January 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28001048/importance-of-the-active-site-canopy-residues-in-an-o2-tolerant-nife-hydrogenase
#5
Emily J Brooke, Rhiannon M Evans, Shams T A Islam, Gerri M Roberts, Sara A M Wehlin, Stephen B Carr, Simon E V Phillips, Fraser A Armstrong
The active site of Hyd-1, an oxygen-tolerant membrane-bound [NiFe]-hydrogenase from Escherichia coli, contains four highly conserved residues that form a "canopy" above the bimetallic center, closest to the site at which exogenous agents CO and O2 interact, substrate H2 binds, and a hydrido intermediate is stabilized. Genetic modification of the Hyd-1 canopy has allowed the first systematic and detailed kinetic and structural investigation of the influence of the immediate outer coordination shell on H2 activation...
December 21, 2016: Biochemistry
https://www.readbyqxmd.com/read/27983881/hysingla%C3%A2-er-a-once-daily-single-entity-hydrocodone-with-abuse-deterrent-properties-in-treating-chronic-nonmalignant-and-nonneuropathic-pain-in-patients-with-osteoarthritis
#6
Louise Taber, Stacy Baldridge, Ellie He, Steven R Ripa
OBJECTIVES: Osteoarthritis (OA)-related chronic pain is associated with physical and psychosocial impairment as well as poorer quality of life. There is limited literature on long-term opioid therapy in OA patients. This post hoc analysis of OA patients assessed the long-term safety and effectiveness of a once-daily, single-entity, extended-release formulation of hydrocodone (HYD) with abuse-deterrent properties for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which other treatment options are inadequate...
January 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/27898971/evaluating-the-impact-of-maternal-vitamin-d-supplementation-on-sow-performance-ii-subsequent-growth-performance-and-carcass-characteristics-of-growing-pigs
#7
J R Flohr, J C Woodworth, J R Bergstrom, M D Tokach, S S Dritz, R D Goodband, J M DeRouchey
A of subsample of 448 growing pigs (PIC 327 × 1050) weaned from 52 sows fed varying dietary vitamin D regimens were used in a split-plot design to determine the effects of maternal and nursery dietary vitamin D on growth performance. Sows were previously administered diets containing vitamin D as vitamin D (800, 2,000, or 9,600 IU/kg) or as 25(OH)D (50 µg [or 2,000 IU vitamin D equivalent]/kg from HyD; DSM Nutritional Products, Parsippany, NJ). Once weaned, pigs were allotted to pens on the basis of previous maternal vitamin D treatment, and then pens were randomly assigned to 1 of 2 nursery vitamin D dietary regimens (2,000 IU of vitamin D/kg or 50 µg 25(OH)D/kg)...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27863798/use-of-soil-amendments-to-immobilize-antimony-and-lead-in-moderately-contaminated-shooting-range-soils
#8
Susan Tandy, Nicola Meier, Rainer Schulin
Shooting ranges are a source of environmental concern around the world as they are a source of toxic antimony (Sb) and lead (Pb). In-situ chemical stabilization is a strategy to reduce metal(loid) leaching and bioavailability. However it is difficult to find the right treatment due to the fact that Pb is a cation and Sb an anion, under oxidised conditions and they often show the opposite mobility in soil, on the application of amendments. A batch experiment was set up with two soils (slightly acidic and alkaline), two red mud based amendments (ViroSoil™ 1 and 2) alone and in combination with two reducing agents (zero valent iron and iron sulphate), to assess the effect of the treatments on metal(loid) leaching and compare it to unamended soil and soil amended with goethite, a known Sb adsorbent...
February 15, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27735784/anaerobic-formate-and-hydrogen-metabolism
#9
Constanze Pinske, R Gary Sawers
Numerous recent developments in the biochemistry, molecular biology, and physiology of formate and H2 metabolism and of the [NiFe]-hydrogenase (Hyd) cofactor biosynthetic machinery are highlighted. Formate export and import by the aquaporin-like pentameric formate channel FocA is governed by interaction with pyruvate formate-lyase, the enzyme that generates formate. Formate is disproportionated by the reversible formate hydrogenlyase (FHL) complex, which has been isolated, allowing biochemical dissection of evolutionary parallels with complex I of the respiratory chain...
October 2016: EcoSal Plus
https://www.readbyqxmd.com/read/27720435/toxic-aromatic-compounds-from-fruits-of-narthecium-ossifragum-l
#10
Marita Vu, Lars Herfindal, Ole Johan Juvik, Anni Vedeler, Svein Haavik, Torgils Fossen
The intake of Narthecium ossifragum, commonly known as bog asphodel, has been associated with toxic effects observed in sheep for centuries. Although the plant has been studied for five centuries little is known about its chemical constituents. Six previously undescribed natural products, naringenin(3 → 6″)luteolin, naringenin(3 → 6″)chrysoeriol, liovil 4-O-β-glucopyranoside, 2,6-dimethoxy cinnamic acid, (E)-4-(3-hydroxy-2,2-dimethylchroman-6-yl)but-3-en-2-one and (E)-4-(4-(((E)-4-hydroxy-3-methylbut-2-en-1-yl)oxy)phenyl)but-3-en-2-one, have been identified from fruits of N...
December 2016: Phytochemistry
https://www.readbyqxmd.com/read/27698451/co-acclimation-of-bacterial-communities-under-stresses-of-hydrocarbons-with-different-structures
#11
Hui Wang, Bin Wang, Wenwen Dong, Xiaoke Hu
Crude oil is a complex mixture of hydrocarbons with different structures; its components vary in bioavailability and toxicity. It is important to understand how bacterial communities response to different hydrocarbons and their co-acclimation in the process of degradation. In this study, microcosms with the addition of structurally different hydrocarbons were setup to investigate the successions of bacterial communities and the interactions between different bacterial taxa. Hydrocarbons were effectively degraded in all microcosms after 40 days...
October 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27686377/risk-of-thrombosis-according-to-need-of-phlebotomies-in-patients-with-polycythemia-vera-treated-with-hydroxyurea
#12
Alberto Alvarez-Larrán, Manuel Pérez-Encinas, Francisca Ferrer-Marín, Juan Carlos Hernández-Boluda, María José Ramírez, Joaquín Martínez-López, Elena Magro, Yasmina Cruz, María Isabel Mata, Pilar Aragües, María Laura Fox, Beatriz Cuevas, Sara Montesdeoca, José Angel Hernández-Rivas, Valentín García-Gutiérrez, María Teresa Gómez-Casares, Juan Luis Steegmann, María Antonia Durán, Montse Gómez, Ana Kerguelen, Abelardo Bárez, Mari Carmen García, Concepción Boqué, José María Raya, Clara Martínez, Manuel Albors, Francesc García, Carmen Burgaleta, Carlos Besses
Hematocrit control below 45% is associated with a lower rate of thrombosis in polycythemia vera. In patients receiving hydroxyurea, this target can be achieved with hydroxyurea alone or with the combination of hydroxyurea plus phlebotomies. However, the clinical implications of phlebotomy requirement under hydroxyurea therapy are unknown. The aim of this study was to evaluate the need for additional phlebotomies during the first five years of hydroxyurea therapy in 533 patients with polycythemia vera. Patients requiring 3 or more phlebotomies per year (n=85, 16%) showed a worse hematocrit control than those requiring 2 or less phlebotomies per year (n=448, 84%)...
January 2017: Haematologica
https://www.readbyqxmd.com/read/27682278/histological-and-biochemical-evidence-related-to-the-collagen-quality-in-torn-rotator-cuff-tendons
#13
S E Varitimidis, Z H Dailiana, D Christou, K Grafanaki, M G Ioannou, C Stathopoulos, K N Malizos
This study investigates the histological background of torn rotator cuff tendons, evaluates the stability of newly synthesized collagen by measuring the hydro-xyproline content and attempts to correlate these findings with the clinical outcome after reconstruction of the rotator cuff. Sixty-one patients underwent reconstruction for a -rotator cuff tear. They were evaluated preoperatively with the Constant-Murley score, MRI and ultrasound. Biopsy samples were taken from chronic rotator cuff tears and histological analysis was performed...
August 2016: Acta Orthopaedica Belgica
https://www.readbyqxmd.com/read/27669895/isolation-purification-and-analysis-of-dissolved-organic-carbon-doc-from-gohagoda-uncontrolled-open-dumpsite-leachate-sri-lanka
#14
Meththika Vithanage, Hasintha Wijesekara, S S Mayakaduwa
Dissolved Organic Carbon (DOC) from landfill leachate may become potentially harmful when it combines with other organic or inorganic substances in wastewaters. Therefore, the aim of this study was to extract and analysis of DOC fractions in uncontrolled dumpsite at Gohagoda, Sri Lanka. Total organic carbon (TOC) and DOC in the leachate were measured. DOC fractions; humic acids (HA), fulvic acids (FA) and the hydrophilic fraction (Hyd) were isolated and purified with the resin techniques. Spectroscopic techniques and elemental analysis were performed to characterize isolated fractions of DOCs...
September 27, 2016: Environmental Technology
https://www.readbyqxmd.com/read/27658760/high-resolution-metabolomics-to-identify-urine-biomarkers-in-corticosteroid-resistant-asthmatic-children
#15
Youngja H Park, Anne M Fitzpatrick, Carl Angelo Medriano, Dean P Jones
BACKGROUND: Corticosteroid (CS) treatment has been established as the first anti-inflammatory treatment for adults and children with asthma. However, a subset of patients fails to respond to combined systemic and inhaled CS treatment. OBJECTIVE: This study is aimed at further understanding CS resistance among severe asthmatic children. METHODS: High resolution metabolomics (HRM) was performed on urine samples from CS-respondent (n=15) and CS-nonrespondent (n=15) children to determine possible urine biomarkers related to CS resistance...
September 19, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27651514/oral-abuse-potential-pharmacokinetics-and-safety-of-once-daily-single-entity-extended-release-hydrocodone-hyd-in-recreational-opioid-users
#16
Stephen C Harris, Alessandra Cipriano, Ram P Kapil, Naama Levy-Cooperman, Salvatore V Colucci, Pierre Geoffroy, Talar Hopyan
OBJECTIVES:  A once-daily, extended-release hydrocodone bitartrate tablet with abuse-deterrent properties (Hysingla ER [HYD]) is available for the treatment of chronic pain in appropriate patients. This study evaluated the oral abuse potential and pharmacokinetics (PK) of HYD intact, chewed, or milled to fine particles in comparison with hydrocodone solution or placebo. DESIGN:  Single-center, double-blind, randomized, five-period, five-treatment crossover study...
September 19, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/27639492/supermolecules-of-poly-n-isopropylacrylamide-complexating-herring-sperm-dna-with-bio-multiple-hydrogen-bonding
#17
Ai-Wei Lee, Cheng-Chen Hsu, Yi-Zu Liu, Po-Li Wei, Jem-Kun Chen
In this study we used the poly(N-isopropylacrylamide) (PNIPAAm) as a medium to blend with an organic DNA, herring sperm DNA (HSD), to generate PNIPAAm-HSD supramolecular complexes. Bio-multiple hydrogen bonding (BMHB) between PNIPAAm and HSD was investigated that changed the temperature responsiveness of PNIPAAm relatively to the HSD concentrations. With blending the HSD into PNIPAAm matrix, the phase separation in solution is completely opposite from that of neat PNIPAAm. Surface property in static water contact angle (SWCA) is also opposite from that of pure PNIPAAm upon increasing HSD content over 60%...
December 1, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27627619/tet3-mediates-alterations-in-the-epigenetic-marker-5hmc-and-akt-pathway-in-steroid-associated-osteonecrosis
#18
Jie Zhao, Xin-Long Ma, Jian-Xiong Ma, Lei Sun, Bin Lu, Ying Wang, Guo-Sheng Xing, Yan Wang, Ben-Chao Dong, Li-Yan Xu, Ming-Jie Kuang, Lin Fu, Hao-Hao Bai, Yue Ma, Wei-Lin Jin
Steroid-associated osteonecrosis (SAON) is one of the common complications of clinical glucocorticoid (GC) administration, with osteocyte apoptosis appearing as the primary histopathological lesion. However, the precise mechanism underlying SAON remains unknown. Epigenetic modification may be a major cause of SAON. Recently, cumulative research revealed that Ten-Eleven Translocation (TET) proteins can catalyze the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and then alter the epigenetic state of DNA...
September 13, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27612614/methodology-for-identification-of-pore-forming-antimicrobial-peptides-from-soy-protein-subunits-%C3%AE-conglycinin-and-glycinin
#19
Ning Xiang, Yuan Lyu, Xiao Zhu, Arun K Bhunia, Ganesan Narsimhan
Antimicrobial peptides (AMPs) inactivate microbial cells through pore formation in cell membrane. Because of their different mode of action compared to antibiotics, AMPs can be effectively used to combat drug resistant bacteria in human health. AMPs can also be used to replace antibiotics in animal feed and immobilized on food packaging films. In this research, we developed a methodology based on mechanistic evaluation of peptide-lipid bilayer interaction to identify AMPs from soy protein. Production of AMPs from soy protein is an attractive, cost-saving alternative for commercial consideration, because soy protein is an abundant and common protein resource...
September 6, 2016: Peptides
https://www.readbyqxmd.com/read/27566174/biosynthesis-of-salmonella-enterica-nife-hydrogenase-5-probing-the-roles-of-system-specific-accessory-proteins
#20
Lisa Bowman, Jonathan Balbach, Julia Walton, Frank Sargent, Alison Parkin
A subset of bacterial [NiFe]-hydrogenases have been shown to be capable of activating dihydrogen-catalysis under aerobic conditions; however, it remains relatively unclear how the assembly and activation of these enzymes is carried out in the presence of air. Acquiring this knowledge is important if a generic method for achieving production of O2-resistant [NiFe]-hydrogenases within heterologous hosts is to be developed. Salmonella enterica serovar Typhimurium synthesizes the [NiFe]-hydrogenase-5 (Hyd-5) enzyme under aerobic conditions...
October 2016: Journal of Biological Inorganic Chemistry: JBIC
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