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https://www.readbyqxmd.com/read/28425152/nmr-structures-and-molecular-dynamics-simulation-of-hylin-a1-peptide-analogs-interacting-with-micelles
#1
Edson Crusca, Amanda Souza Câmara, Carolina Oliveira Matos, Reinaldo Marchetto, Eduardo Maffud Cilli, Luciano Morais Lião, Aline Lima de Oliveira
Antimicrobial peptides are recognized candidates with pharmaceutical potential against epidemic emerging multi-drug resistant bacteria. In this study, we use nuclear magnetic resonance spectroscopy and molecular dynamics simulations to determine the unknown structure and evaluate the interaction with dodecylphosphatidylcholine (DPC) and sodium dodecylsulphate (SDS) micelles with three W(6) -Hylin-a1 analogs antimicrobial peptides (HyAc, HyK, and HyD). The HyAc, HyK, and HyD bound to DPC micelles are all formed by a unique α-helix structure...
April 20, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28388567/synthesis-bioactivity-3d-qsar-studies-of-novel-dibenzofuran-derivatives-as-ptp-meg2-inhibitors
#2
Ying Ma, Hui-Yu Wei, Yu-Ze Zhang, Wen-Yan Jin, Hong-Lian Li, Hui-Zhou, Xian-Chao Cheng, Run-Ling Wang
PTP-MEG2 plays a critical role in the diverse cell signalling processes, so targeting PTP-MEG2 is a promising strategy for various human diseases treatments. In this study, a series of novel dibenzofuran derivatives was synthesized and assayed for their PTP-MEG2 inhibitory activities. 10a with highest inhibitory activity (320 nM) exhibited significant selectivity for PTP-MEG2 over its close homolog SHP2, CDC25 (IC50 > 50 μM). By means of the powerful ''HipHop'' technique, a 3D-QSAR study was carried out to explore structure activity relationship of these molecules...
March 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28371835/effectiveness-and-safety-of-once-daily-extended-release-hydrocodone-in-individuals-previously-receiving-immediate-release-oxycodone-for-chronic-pain
#3
Joseph Pergolizzi, Maribeth Kowalski, Ellie He
Objectives. : This study evaluated the safety and effectiveness of a once-daily, single-entity, extended-release hydrocodone bitartrate (HYD) among patients with chronic noncancer and non-neuropathic pain who required opioid rotation from a previous analgesic regimen that primarily consisted of immediate-release (IR) oxycodone. Methods. : Post hoc analyses of a primary study that assessed HYD 20 to 120 mg over a 52-week period are presented. The primary study included a dose titration period (up to 45 days), a 52-week maintenance period, and an optional taper period (up to 14 days)...
March 28, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28360938/citrobacter-amalonaticus-y19-for-constitutive-expression-of-carbon-monoxide-dependent-hydrogen-production-machinery
#4
Satish Kumar Ainala, Eunhee Seol, Jung Rae Kim, Sunghoon Park
BACKGROUND: Citrobacter amalonaticus Y19 is a good biocatalyst for production of hydrogen (H2) from oxidation of carbon monoxide (CO) via the so-called water-gas-shift reaction (WGSR). It has a high H2-production activity (23.83 mmol H2 g(-1) cell h(-1)) from CO, and can grow well to a high density on various sugars. However, its H2-production activity is expressed only when CO is present as an inducer and in the absence of glucose. RESULTS: In order to avoid dependency on CO and glucose, in the present study, the native CO-inducible promoters of WGSR operons (CO dehydrogenase, CODH, and CODH-dependent hydrogenase, CO-hyd) in Y19 were carefully analyzed and replaced with strong and constitutive promoters screened from Y19...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28320742/development-of-lc3-gabarap-sensors-containing-a-lir-and-a-hydrophobic-domain-to-monitor-autophagy
#5
You-Kyung Lee, Yong-Woo Jun, Ha-Eun Choi, Yang Hoon Huh, Bong-Kiun Kaang, Deok-Jin Jang, Jin-A Lee
Macroautophagy allows for bulk degradation of cytosolic components in lysosomes. Overexpression of GFP/RFP-LC3/GABARAP is commonly used to monitor autophagosomes, a hallmark of autophagy, despite artifacts related to their overexpression. Here, we developed new sensors that detect endogenous LC3/GABARAP proteins at the autophagosome using an LC3-interacting region (LIR) and a short hydrophobic domain (HyD). Among HyD-LIR-GFP sensors harboring LIR motifs of 34 known LC3-binding proteins, HyD-LIR(TP)-GFP using the LIR motif from TP53INP2 allowed detection of all LC3/GABARAPs-positive autophagosomes...
April 13, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28318946/easy-and-rapid-preparation-of-benzoylhydrazides-and-their-diazene-derivatives-as-inhibitors-of-15-lipoxygenase
#6
Cristian Tirapegui, Williams Acevedo-Fuentes, Pablo Dahech, Claudia Torrent, Pablo Barrias, Macarena Rojas-Poblete, Carolina Mascayano
Two series of diaza derivatives were prepared by solvent-free condensation of benzoic acid and 4-substituted phenylhydrazines in order to obtain phenylhydrazides (HYD series) and, by oxidation of these compounds, the corresponding benzoyldiazenes (DIA series). Both sets were evaluated as inhibitors of soybean 15-lipoxygenase activity and antioxidant capability in the FRAP and CUPRAC assays. The most potent inhibitors of both series exhibited IC50 values in the low micromolar range. Kinetic studies showed that at least the more active compounds were competitive inhibitors...
March 8, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28268018/elastin-like-protein-hyaluronic-acid-elp-ha-hydrogels-with-decoupled-mechanical-and-biochemical-cues-for-cartilage-regeneration
#7
Danqing Zhu, Huiyuan Wang, Pavin Trinh, Sarah C Heilshorn, Fan Yang
Hyaluronic acid (HA) is a major component of cartilage extracellular matrix and is an attractive material for use as 3D injectable matrices for cartilage regeneration. While previous studies have shown the promise of HA-based hydrogels to support cell-based cartilage formation, varying HA concentration generally led to simultaneous changes in both biochemical cues and stiffness. How cells respond to the change of biochemical content of HA remains largely unknown. Here we report an adaptable elastin-like protein-hyaluronic acid (ELP-HA) hydrogel platform using dynamic covalent chemistry, which allows variation of HA concentration without affecting matrix stiffness...
May 2017: Biomaterials
https://www.readbyqxmd.com/read/28197588/an-unexpected-pathway-for-hydrodesulfurization-of-gazole-over-a-comos-active-phase-supported-on-a-mesoporous-tio2-catalyst
#8
I Naboulsi, C Felipe Linares Aponte, B Lebeau, S Brunet, L Michelin, M Bonne, J L Blin
Using dual mesoporous titania as a support, due to the presence of intrinsic Brönsted acid sites, the main approach to 4,6-dimethylbenzothiophene (46DMDBT) hydrodesulfurization (HDS) becomes the direct desulfurization (DDS) route through isomerization and dismutation reactions, instead of the hydrogenation (HYD) pathway usually observed with a conventional promoted (by Ni or Co) MoS2/Al2O3 catalyst.
February 15, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28146635/mitochondria-and-nucleus-dual-delivery-system-to-overcome-dox-resistance
#9
Han Cui, Meng-Lei Huan, Wei-Liang Ye, Dao-Zhou Liu, Zeng-Hui Teng, Qi-Bing Mei, Si-Yuan Zhou
Doxorubicin (DOX) is a broad-spectrum chemotherapy drug to treat tumors. However, severe side effects and development of DOX resistance hinder its clinical application. In order to overcome DOX resistance, DOX/TPP-DOX@Pasp-hyd-PEG-FA micelles were prepared by using newly synthesized comb-like amphiphilic material Pasp-hyd-PEG-FA. Drug released in vitro from micelles showed a pH-dependent manner. DOX/TPP-DOX@Pasp-hyd-PEG-FA induced more apoptosis in KB cell and MCF-7/ADR cell than DOX@Pasp-hyd-PEG-FA. Confocal laser scanning microscopy experiment indicated that DOX/TPP-DOX@Pasp-hyd-PEG-FA delivered TPP-DOX and DOX to the nucleus and mitochondria of the tumor cell simultaneously...
February 17, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28132874/glycation-inhibitors-extend-yeast-chronological-lifespan-by-reducing-advanced-glycation-end-products-and-by-back-regulation-of-proteins-involved-in-mitochondrial-respiration
#10
Rubina S Kazi, Reema M Banarjee, Arati B Deshmukh, Gouri V Patil, Mashanipalya G Jagadeeshaprasad, Mahesh J Kulkarni
Advanced Glycation End products (AGEs) are implicated in aging process. Thus, reducing AGEs by using glycation inhibitors may help in attenuating the aging process. In this study using Saccharomyces cerevisiae yeast system, we show that Aminoguanidine (AMG), a well-known glycation inhibitor, decreases the AGE modification of proteins in non-calorie restriction (NR) (2% glucose) and extends chronological lifespan (CLS) similar to that of calorie restriction (CR) condition (0.5% glucose). Proteomic analysis revealed that AMG back regulates the expression of differentially expressed proteins especially those involved in mitochondrial respiration in NR condition, suggesting that it switches metabolism from fermentation to respiration, mimicking CR...
March 6, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28110257/acidification-with-nitric-acid-improves-chemical-characteristics-and-reduces-phytotoxicity-of-alkaline-chars
#11
Fernando Fornes, Rosa Maria Belda
Charred organic matter is recently receiving attention for its potential use as soilless growth medium. However, depending on its origin and on the manufacturing technology, it can result toxic for plants. This fact implies that a detoxifying treatment ought to be devised in order to reclaim char in this way. We have studied three materials which combine these factors: two pyrolyzed biochars, one from forest waste (BCH-FW) and another from olive mill waste (BCH-OMW), and one hydrothermally carbonized hydrochar from forest waste (HYD-FW)...
January 19, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28106250/assessment-of-biochar-and-hydrochar-as-minor-to-major-constituents-of-growing-media-for-containerized-tomato-production
#12
Fernando Fornes, Rosa M Belda, Pascual Fernández de Córdova, Jaime Cebolla-Cornejo
BACKGROUND: Chars are emerging materials as constituents of growth media. However, chars of different origin differ in their characteristics and more studies are needed to ratify them for such role. The characteristics of coir mixed with 0, 10, 25, 50, 75, and 100 (% v:v) of two biochars, from forest waste (BCH-FW) and from olive mill waste (BCH-OMW), and one hydrochar, from forest waste (HYD-FW), and their effects on growth, yield and fruit quality of two tomato cultivars (Gransol RZ and Cuarenteno) were assessed...
January 20, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28105804/cavity-enhanced-raman-spectroscopy-in-the-biosciences-in-situ-multicomponent-and-isotope-selective-gas-measurements-to-study-hydrogen-production-and-consumption-by-escherichia-coli
#13
Thomas W Smith, Michael Hippler
Recently we introduced cavity-enhanced Raman spectroscopy (CERS) with optical feedback cw-diode lasers as a sensitive analytical tool. Here we report improvements made on the technique and its first application in the biosciences for in situ, multicomponent, and isotope selective gas measurements to study hydrogen production and consumption by Escherichia coli. Under anaerobic conditions, cultures grown on rich media supplemented with d-glucose or glycerol produce H2 and simultaneously consume some of it. By introducing D2 in the headspace, hydrogen production and consumption could be separated due to the distinct spectroscopic signatures of isotopomers...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28072811/evaluation-of-the-ototoxicity-potential-of-once-daily-single-entity-hydrocodone-in-patients-with-chronic-pain-results-of-two-phase-3-clinical-studies
#14
Kathleen Campbell, J Walter Kutz, Angela Shoup, Warren Wen, Shau Yu Lynch, Ellie He, Steven R Ripa
BACKGROUND: Use/misuse of the opioid combination hydrocodone-acetaminophen has been associated with permanent hearing loss. Although reports have been rare, this potential effect can have significant detrimental effect on patients' overall quality of life. To date, the ototoxic effect of hydrocodone alone has not been systematically investigated. OBJECTIVE: In this report, we aimed to evaluate the potential ototoxicity of a novel, single-entity, once-daily, extended-release hydrocodone tablet (Hysingla® ER; HYD)...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28025523/development-of-a-uplc-tq-ms-approach-for-the-determination-of-eleven-bioactive-components-in-haizao-yuhu-decoction-plus-minus-haizao-and-gancao-drug-combination-after-oral-administration-in-a-rat-model-of-hypothyroidism
#15
Yingchang Ma, Yang Zhang, Yuanjuan Zhai, Zhenhua Zhu, Ying Pan, Dawei Qian, Shulan Su, Xinsheng Fan, Jinao Duan
Haizao Yuhu Decoction (HYD) has been used for approximately 500 years and is well-known in Traditional Chinese Medicine for its efficacy in the treatment of thyroid-related diseases. In this study, a rapid liquid chromatography-tandem mass spectrometry method was developed for the determination of liquiritin, naringin, hesperidin, peimine, liquiritigenin, glycyrrhizic acid, bergapten, nobiletin, osthole, and glycyrrhetinic acid in rat plasma to investigate the pharmacokinetic profile of different HYD prescriptions in a rat model of hypothyroidism...
December 22, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28018474/traditional-chinese-medicine-huannao-yicong-decoction-extract-decreases-tau-hyperphosphorylation-in-the-brain-of-alzheimer-s-disease-model-rats-induced-by-a%C3%AE-1-42
#16
Yu Cao, Xingxing Jia, Yun Wei, Meixia Liu, Jiangang Liu, Hao Li
Objective. Huannao Yicong Decoction (HYD, ) has been shown to improve the learning and memory capabilities of Alzheimer's disease (AD) subjects. However, the underlying mechanism remains to be determined. Methods. Sixty Sprague-Dawley rats were divided equally and randomly into five different groups including control, positive control, and HYD granules of low dose, medium dose, and high dose by daily gavage. The sham-treated rats were also given the same volume of sterile water by gavage. Twelve SD rats were treated with the same amount of physiological saline...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28012250/the-effect-of-ureaplasma-urealyticum-on-the-level-of-p34h-expression-the-activity-of-hyaluronidase-and-dna-fragmentation-in-human-spermatozoa
#17
Xiao-Ping Ma, Xiao-Qin Gao
BACKGROUND: To study the effect of Ureaplasma urealyticum on the level of P34H expression, the activity of hyaluronidase, and the DNA fragmentation in human spermatozoa. METHOD: Western blot was used to detect the level of P34H expression on spermatozoa.The localization of this protein on human spermatozoa was determined by indirect immunofluorescent and observed by laser scanning confocal microscope. The activity of hyaluronidase was examined by improved fixed-substrate film method...
January 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28001048/importance-of-the-active-site-canopy-residues-in-an-o2-tolerant-nife-hydrogenase
#18
Emily J Brooke, Rhiannon M Evans, Shams T A Islam, Gerri M Roberts, Sara A M Wehlin, Stephen B Carr, Simon E V Phillips, Fraser A Armstrong
The active site of Hyd-1, an oxygen-tolerant membrane-bound [NiFe]-hydrogenase from Escherichia coli, contains four highly conserved residues that form a "canopy" above the bimetallic center, closest to the site at which exogenous agents CO and O2 interact, substrate H2 binds, and a hydrido intermediate is stabilized. Genetic modification of the Hyd-1 canopy has allowed the first systematic and detailed kinetic and structural investigation of the influence of the immediate outer coordination shell on H2 activation...
December 21, 2016: Biochemistry
https://www.readbyqxmd.com/read/27983881/hysingla%C3%A2-er-a-once-daily-single-entity-hydrocodone-with-abuse-deterrent-properties-in-treating-chronic-nonmalignant-and-nonneuropathic-pain-in-patients-with-osteoarthritis
#19
MULTICENTER STUDY
Louise Taber, Stacy Baldridge, Ellie He, Steven R Ripa
OBJECTIVES: Osteoarthritis (OA)-related chronic pain is associated with physical and psychosocial impairment as well as poorer quality of life. There is limited literature on long-term opioid therapy in OA patients. This post hoc analysis of OA patients assessed the long-term safety and effectiveness of a once-daily, single-entity, extended-release formulation of hydrocodone (HYD) with abuse-deterrent properties for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which other treatment options are inadequate...
January 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/27898971/evaluating-the-impact-of-maternal-vitamin-d-supplementation-on-sow-performance-ii-subsequent-growth-performance-and-carcass-characteristics-of-growing-pigs
#20
J R Flohr, J C Woodworth, J R Bergstrom, M D Tokach, S S Dritz, R D Goodband, J M DeRouchey
A of subsample of 448 growing pigs (PIC 327 × 1050) weaned from 52 sows fed varying dietary vitamin D regimens were used in a split-plot design to determine the effects of maternal and nursery dietary vitamin D on growth performance. Sows were previously administered diets containing vitamin D as vitamin D (800, 2,000, or 9,600 IU/kg) or as 25(OH)D (50 µg [or 2,000 IU vitamin D equivalent]/kg from HyD; DSM Nutritional Products, Parsippany, NJ). Once weaned, pigs were allotted to pens on the basis of previous maternal vitamin D treatment, and then pens were randomly assigned to 1 of 2 nursery vitamin D dietary regimens (2,000 IU of vitamin D/kg or 50 µg 25(OH)D/kg)...
November 2016: Journal of Animal Science
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