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https://www.readbyqxmd.com/read/29776711/preliminary-assessment-of-the-diagnostic-performances-of-a-new-rapid-diagnostic-test-for-the-serodiagnosis-of-human-cystic-echinococcosis
#1
REVIEW
Ambra Vola, Francesca Tamarozzi, Rahmah Noordin, Muhammad Hafiznur Yunus, Sam Khanbabaie, Annalisa De Silvestri, Enrico Brunetti, Mara Mariconti
Rapid diagnostic tests for cystic echinococcosis (CE) are convenient to support ultrasound diagnosis in uncertain cases, especially in resource-limited settings. We found comparable diagnostic performances of the experimental Hyd Rapid Test and the commercial VIRapid HYDATIDOSIS Test, used in our diagnostic laboratory, using samples from well-characterized hepatic CE cases.
April 14, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29745799/sweat-from-gland-to-skin-surface-production-transport-and-skin-absorption
#2
Nicola Margaret Gerrett, Katy E Griggs, Bernard Redortier, Thomas Voelcker, Narihiko Kondo, George Havenith
By combining galvanic skin conductance (GSC), stratum corneum hydration (HYD) and regional surface sweat rate (RSR) measurements at the arm, thigh, back and chest, we closely monitored the passage of sweat from gland to skin surface. Through a varied exercise-rest protocol, sweating was increased slowly and decreased in 16 male and female human participants (25.3 {plus minus} 4.7 yrs, 174.6 {plus minus} 10.1 cm, 71.3 {plus minus} 12.0 kg, 53.0 {plus minus} 6.8 ml∙kg∙min-1 ). ∆GSC and HYD increased prior to RSR, indicating pre-secretory sweat gland activity and skin hydration...
May 10, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29696103/conserved-histidine-adjacent-to-the-proximal-cluster-tunes-the-anaerobic-reductive-activation-of-escherichia-coli-membrane-bound-nife-hydrogenase-1
#3
Lindsey A Flanagan, Harriet S Chidwick, Julia Walton, James W B Moir, Alison Parkin
[NiFe] hydrogenases are electrocatalysts that oxidize H2 at a rapid rate without the need for precious metals. All membrane-bound [NiFe] hydrogenases (MBH) possess a histidine residue that points to the electron-transfer iron sulfur cluster closest ("proximal") to the [NiFe] H2 -binding active site. Replacement of this amino acid with alanine induces O2 sensitivity, and this has been attributed to the role of the histidine in enabling the reversible O2 -induced over-oxidation of the [Fe4 S3 Cys2 ] proximal cluster possessed by all O2 -tolerant MBH...
March 2018: ChemElectroChem
https://www.readbyqxmd.com/read/29687613/free-living-continuous-hypo-hydration-and-cardiovascular-response-to-exercise-in-a-heated-environment
#4
Kate S Early, Conrad P Earnest, Bailey Theall, Nathan P Lemoine, Brian Harrell, Neil M Johannsen
Chronic dehydration (DEH) and heat stress combined with poor cardiovascular (CV) health may influence physiological responses to exercise. We examined the effects of free-living induced hypo-hydration on physiological responses to exercise in a heated environment and whether resting CV health is related to these changes. Participants (N = 16, 20.6 ± 1.2 years) were randomized to 3 days of voluntary fluid restriction (DEH) or intake (hydration [HYD]) followed by an exercise bout. CV health was assessed by flow-mediated dilation (FMD), pulse wave analysis, and heart rate variability (HRV)...
April 2018: Physiological Reports
https://www.readbyqxmd.com/read/29604365/effects-of-ceftriaxone-on-hydrocodone-seeking-behavior-and-glial-glutamate-transporters-in-p-rats
#5
Fahad S Alshehri, Alqassem Y Hakami, Yusuf S Althobaiti, Youssef Sari
Hydrocodone (HYD) is one of the most widely prescribed opioid analgesic drugs. Several neurotransmitters are involved in opioids relapse. Among these neurotransmitters, glutamate is suggested to be involved in opioid dependence and relapse. Glutamate is regulated by several glutamate transporters, including glutamate transporter 1 (GLT-1) and cystine/glutamate transporter (xCT). In this study, we investigated the effects of ceftriaxone (CEF) (200 mg/kg, i.p.), known to upregulate GLT-1 and xCT, on reinstatement to HYD (5 mg/kg, i...
March 28, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29576798/jinkui-shenqi-pills-ameliorate-asthma-with-kidney-yang-deficiency-by-enhancing-the-function-of-the-hypothalamic-pituitary-adrenal-axis-to-regulate-t-helper-1-2-imbalance
#6
Bing Ji, Yuan-Yuan Li, Wei-Ji Yang, Li-Zong Zhang, Ming-Sun Fang, Hui-Ying Fu, Qi-Yang Shou
The aim of the study was to investigate the effects and underlying mechanism of JKSQP in a rat model of asthma with kidney-yang deficiency (KYD). Materials and Methods . Hydrocortisone (HYD) was used to establish the rat model of KYD; rats were then sensitized and challenged with ovalbumin (OVA). JKSQP was administered to OVA-challenged rats, and the changes in signs and symptoms of KYD were observed. The leukocyte number and subpopulations in bronchoalveolar lavage fluid (BALF) were counted and the cells were stained with Wright-Giemsa dye...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29571163/performance-comparison-between-multienzymes-loaded-single-and-dual-electrodes-for-the-simultaneous-electrochemical-detection-of-adenosine-and-metabolites-in-cancerous-cells
#7
Khalil K Hussain, Mahmood H Akhtar, Moo-Hyun Kim, Dong-Keun Jung, Yoon-Bo Shim
The analytical performance of the multi enzymes loaded single electrode sensor (SES) and dual electrode sensor (DES) was compared for the detection of adenosine and metabolites. The SES was fabricated by covalent binding of tri-enzymes, adenosine deaminase (ADA), purine nucleoside phosphorylase (PNP), and xanthine oxidase (XO) along with hydrazine (Hyd) onto a functionalized conducting polymer [2,2:5,2-terthiophene-3-(p-benzoic acid)] (pTTBA). The enzyme reaction electrode in DES was fabricated by covalent binding of ADA and PNP onto pTTBA coated on Au nanoparticles...
March 15, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29528792/selumetinib-in-combination-with-dacarbazine-in-patients-with-metastatic-uveal-melanoma-a-phase-iii-multicenter-randomized-trial-sumit
#8
Richard D Carvajal, Sophie Piperno-Neumann, Ellen Kapiteijn, Paul B Chapman, Stephen Frank, Anthony M Joshua, Josep M Piulats, Pascal Wolter, Veronique Cocquyt, Bartosz Chmielowski, T R Jeffry Evans, Lauris Gastaud, Gerald Linette, Carola Berking, Jacob Schachter, Manuel J Rodrigues, Alexander N Shoushtari, Delyth Clemett, Dana Ghiorghiu, Gabriella Mariani, Shirley Spratt, Susan Lovick, Peter Barker, Elaine Kilgour, Zhongwu Lai, Gary K Schwartz, Paul Nathan
Purpose Uveal melanoma is the most common primary intraocular malignancy in adults with no effective systemic treatment option in the metastatic setting. Selumetinib (AZD6244, ARRY-142886) is an oral, potent, and selective MEK1/2 inhibitor with a short half-life, which demonstrated single-agent activity in patients with metastatic uveal melanoma in a randomized phase II trial. Methods The Selumetinib (AZD6244: ARRY-142886) (Hyd-Sulfate) in Metastatic Uveal Melanoma (SUMIT) study was a phase III, double-blind trial ( ClinicalTrial...
April 20, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29517481/hydrophobins-contribute-to-root-colonization-and-stress-responses-in-the-rhizosphere-competent-insect-pathogenic-fungus-beauveria-bassiana
#9
Soumya Moonjely, Nemat O Keyhani, Michael J Bidochka
The hyd1/hyd2 hydrophobins are important constituents of the conidial cell wall of the insect pathogenic fungus Beauveria bassiana. This fungus can also form intimate associations with several plant species. Here, we show that inactivation of two Class I hydrophobin genes, hyd1 or hyd2, significantly decreases the interaction of B. bassiana with bean roots. Curiously, the ∆hyd1/∆hyd2 double mutant was less impaired in root association than Δhyd1 or Δhyd2. Loss of hyd genes affected growth rate, conidiation ability and oosporein production...
April 2018: Microbiology
https://www.readbyqxmd.com/read/29505869/tumor-targeting-and-ph-responsive-nanoparticles-from-hyaluronic-acid-for-the-enhanced-delivery-of-doxorubicin
#10
Jianhong Liao, Haoran Zheng, Zengming Fei, Bo Lu, Hua Zheng, Dan Li, Xiong Xiong, Ying Yi
In this study, intracellular pH-responsive nanoparticles (NPs) of hyaluronic acid-hydrazone linkage-doxorubicin (HA-hyd-DOX) were designed and prepared for acid-triggered release of doxorubicin through a hydrazone linkage. A series of amphiphilic polymeric prodrugs were obtained, which can be self-assembled in aqueous media, the formed NPs exhibited a spherical core-shell type and the uniform size was ranging from 167 to 220nm. Moreover, the HA-hyd-DOX NPs exhibited a good stability in vitro and the drug release profiles showed that the DOX release was obviously mediated by pH gradient...
July 1, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29462633/improved-stability-of-tuberculosis-drug-fixed-dose-combination-using-isoniazid-caffeic-acid-and-vanillic-acid-cocrystal
#11
Swapna Battini, M K Chaitanya Mannava, Ashwini Nangia
The classic fixed-dose combination (FDC) of 4 tuberculosis drugs, namely rifampicin (RIF), isoniazid (INH), pyrazinamide (PZA), and ethambutol dihydrochloride (EDH) has the twin issues of physical stability and RIF cross-reaction in the 4-FDC. The major reason for these quality issues is the interaction between RIF and INH to yield isonicotinyl hydrazone in drug tablets. Pharmaceutical cocrystals of INH with caffeic acid (CFA) (PZA + EDH + RIF + INH-CFA cocrystal) and vanillic acid (VLA) (PZA + EDH + RIF + INH-VLA cocrystal) are able to stabilize the FDC formulation compared with the reference batch (PZA + EDH + RIF + INH)...
February 17, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29454838/analysis-of-cocaine-adulterants-in-human-brain-in-cases-of-drug-related-death
#12
Marianne Knuth, Oliver Temme, Thomas Daldrup, Evelyn Pawlik
For different reasons, street cocaine is often diluted with pharmacologically active substances, the so-called adulterants such as levamisole or hydroxyzine. A controversial debate exists currently on the uptake of adulterants from cocaine preparations and drug-related death. Previous research convincingly argues that serious adverse side effects that affect the central nervous and cardiovascular systems can be a consequence of adulterated cocaine. AIMS: Having identified the presence of adulterants in lung tissue and blood, the concentrations of these substances in brain, an important target location, was of interest...
April 2018: Forensic Science International
https://www.readbyqxmd.com/read/29347057/revisiting-the-use-of-the-immersed-boundary-lattice-boltzmann-method-for-simulations-of-suspended-particles
#13
L Mountrakis, E Lorenz, A G Hoekstra
The immersed-boundary lattice-Boltzmann method (IB-LBM) is increasingly being used in simulations of dense suspensions. These systems are computationally very expensive and can strongly benefit from lower resolutions that still maintain the desired accuracy for the quantities of interest. IB-LBM has a number of free parameters that have to be defined, often without exact knowledge of the tradeoffs, since their behavior in low resolutions is not well understood. Such parameters are the lattice constant Δx, the number of vertices N_{v}, the interpolation kernel ϕ, and the LBM relaxation time τ...
July 2017: Physical Review. E
https://www.readbyqxmd.com/read/29278813/a-sandwich-type-electrochemical-immunosensor-based-on-in-situ-silver-deposition-for-determination-of-serum-level-of-her2-in-breast-cancer-patients
#14
Mojtaba Shamsipur, Mahdi Emami, Leila Farzin, Reza Saber
The sensitive quantification of Human Epidermal growth factor Receptor 2 (HER2), as a key prognostic tumor marker, plays a critical role in screening, early diagnosis and management of breast cancer. This paper describes a sandwich-type immunoassay with silver signal enhancement strategy for highly sensitive detection of HER2. For this purpose, the target capturing step was designed by functionalization of 3-aminopropyltrimethoxysilane coated magnetite nanoparticles with antibody (antiHER2/APTMS-Fe3 O4 ), as a platform bioconjugate (PB), and immobilized at a bare GCE...
April 30, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29239983/effects-of-2-dehydration-on-lactate-concentration-during-constant-load-cycling
#15
J M Green, Miller Bl, J D Simpson, Dubroc Dr, Keyes Aa, Neal Kk, Gann Jj, Andre Tl
The lactate [La] threshold can predict endurance performance potential. Dehydration may alter [La] threshold. This study examined effects of dehydration on [La] response during constant load cycling. Recreationally fit (VO2 peak = 48.7 ± 5.2 ml•kg•min) male participants (n=9) completed 2 x 40 min constant-load cycling trials; euhydrated (HYD) and following previous evening passive (water bath) dehydration (2% body weight, DEH) (HYD and DEH counterbalanced). [La], heart rate (HR), 10 point Omni Ratings of Perceived Exertion (RPE) and rectal temperature (Trec) were measured following warm-up and at 10, 20, 30, and 40 min...
December 11, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29039666/comparative-assessment-of-computational-methods-for-free-energy-calculations-of-ionic-hydration
#16
COMPARATIVE STUDY
Haiyang Zhang, Yang Jiang, Hai Yan, Ziheng Cui, Chunhua Yin
Experimental observations for ionic hydration free energies are highly debated mainly due to the ambiguous absolute hydration free energy of proton, ΔGhyd * (H+ ). Hydration free energies (HFEs) of the 112 singly charged ions in the Minnesota solvation database were predicted by six methods with explicit and implicit solvent models, namely, thermodynamic integration (TI), energy representation module (ERmod), three-dimensional reference interaction site model (3D-RISM), and continuum solvation models based on the quantum mechanical charge density (SMD) and on the Poisson-Boltzmann (PB) and generalized Born (GB) theories...
November 27, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29017426/investigations-on-the-influence-of-zidovudine-in-the-pharmacokinetics-of-isoniazid-and-its-hepatotoxic-metabolites-in-rats
#17
Raghu Ramanathan, Karthikeyan Sivanesan
The HIV-infected patients are co-infected with many bacterial infections in which tuberculosis is most common found worldwide. These patients are often administered with combined therapy of anti-retroviral and anti-tubercular drugs which leads to several complications including hepatotoxicity or adverse drug interactions. The drug-drug interactions between the anti-retroviral and anti-tubercular drugs are not clearly defined and hence, this study was conducted to evaluate the pharmacokinetic drug-drug interactions of Zidovudine (AZT) with Isoniazid (INH) and its hepatotoxic metabolites...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29016880/evaluation-of-the-relative-intranasal-abuse-potential-of-a-hydrocodone-extended-release-tablet-formulated-with-abuse-deterrence-technology-in-nondependent-recreational-opioid-users
#18
Mary Bond, Kerri A Schoedel, Laura Rabinovich-Guilatt, Maciej Gasior, William Tracewell, Richard Malamut, Yuju Ma, Lynn R Webster
Objective: To assess the intranasal abuse potential of hydrocodone extended-release (ER) tablets developed with CIMA Abuse-Deterrence Technology compared with hydrocodone powder and hydrocodone bitartrate ER capsules (Zohydro ER, original formulation [HYD-OF]). Design: Single-dose, randomized, double-blind, quadruple-dummy, active- and placebo-controlled, crossover study. Setting: One US site. Subjects: Healthy, adult, nondependent, recreational opioid users...
June 14, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28992013/effect-of-trace-mineral-source-on-mineral-status-and-performance-of-beef-steers-fed-low-or-high-sulfur-diets
#19
S J Hartman, O N Genther-Schroeder, S L Hansen
A 2 × 2 factorial assessed the effect of trace mineral (TM) sources fed within low- or high-S diets on the mineral status and performance of cattle. Angus crossbred steers ( = 48; 6/pen) were blocked by BW (316 ± 16.6 kg), assigned to low-S (0.27%; LS) or high-S (0.54%; HS; added as CaSO) diets, and supplemented TM at 10 mg Cu, 30 mg Zn, and 20 mg Mn/kg DM from hydroxy (HYD; IntelliBond; Micronutrients USA LLC, Indianapolis, IN) or inorganic (sulfates; ING) sources ( = 12 steers/treatment). Steers were fed corn silage and corn-based diets via GrowSafe bunks in the growing period (GP; 84 d) and finishing period (FP; 77 d), respectively...
September 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28991996/effect-of-trace-mineral-source-on-mineral-status-and-performance-of-beef-steers-fed-low-or-high-sulfur-diets
#20
S J Hartman, O N Genther-Schroeder, S L Hansen
A 2 × 2 factorial assessed the effect of trace mineral (TM) sources fed within low- or high-S diets on the mineral status and performance of cattle. Angus crossbred steers ( = 48; 6/pen) were blocked by BW (316 ± 16.6 kg), assigned to low-S (0.27%; LS) or high-S (0.54%; HS; added as CaSO) diets, and supplemented TM at 10 mg Cu, 30 mg Zn, and 20 mg Mn/kg DM from hydroxy (HYD; IntelliBond; Micronutrients USA LLC, Indianapolis, IN) or inorganic (sulfates; ING) sources ( = 12 steers/treatment). Steers were fed corn silage and corn-based diets via GrowSafe bunks in the growing period (GP; 84 d) and finishing period (FP; 77 d), respectively...
September 2017: Journal of Animal Science
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