keyword
https://read.qxmd.com/read/37209656/whole-genome-resequencing-to-unveil-genetic-characteristics-and-selection-signatures-of-specific-pathogen-free-ducks
#21
JOURNAL ARTICLE
Lanlan Li, Jinqiang Quan, Caixia Gao, Hongyi Liu, Haibo Yu, Hongyan Chen, Changyou Xia, Shengguo Zhao
Specific pathogen-free ducks are important high-grade laboratory animals, with a key role in research related to poultry biosecurity, production, and breeding. However, the genetic characteristics of experimental duck varieties remain poorly explored. Herein we performed whole-genome resequencing to construct a single nucleotide polymorphism genetic map of the genomes of 3 experimental duck varieties [Jinding ducks (JD), Shaoxing ducks (SX), and Fujian Shanma ducks (SM)] to determine their genetic characteristics and identify selection signatures...
April 24, 2023: Poultry Science
https://read.qxmd.com/read/37100060/the-rna-editor-adar2-promotes-immune-cell-trafficking-by-enhancing-endothelial-responses-to-interleukin-6-during-sterile-inflammation
#22
JOURNAL ARTICLE
Aikaterini Gatsiou, Simon Tual-Chalot, Matteo Napoli, Almudena Ortega-Gomez, Tommy Regen, Rachit Badolia, Valeriana Cesarini, Claudia Garcia-Gonzalez, Raphael Chevre, Giorgia Ciliberti, Carlos Silvestre-Roig, Maurizio Martini, Jedrzej Hoffmann, Rana Hamouche, Joseph R Visker, Nikolaos Diakos, Astrid Wietelmann, Domenico Alessandro Silvestris, Georgios Georgiopoulos, Ali Moshfegh, Andre Schneider, Wei Chen, Stefan Guenther, Johannes Backs, Shin Kwak, Craig H Selzman, Kimon Stamatelopoulos, Stefan Rose-John, Christian Trautwein, Ioakim Spyridopoulos, Thomas Braun, Ari Waisman, Angela Gallo, Stavros G Drakos, Stefanie Dimmeler, Markus Sperandio, Oliver Soehnlein, Konstantinos Stellos
Immune cell trafficking constitutes a fundamental component of immunological response to tissue injury, but the contribution of intrinsic RNA nucleotide modifications to this response remains elusive. We report that RNA editor ADAR2 exerts a tissue- and stress-specific regulation of endothelial responses to interleukin-6 (IL-6), which tightly controls leukocyte trafficking in IL-6-inflamed and ischemic tissues. Genetic ablation of ADAR2 from vascular endothelial cells diminished myeloid cell rolling and adhesion on vascular walls and reduced immune cell infiltration within ischemic tissues...
May 9, 2023: Immunity
https://read.qxmd.com/read/37080116/inherited-human-znf341-deficiency
#23
REVIEW
Vivien Béziat, Claire Fieschi, Mana Momenilandi, Mélanie Migaud, Brahim Belaid, Reda Djidjik, Anne Puel
Typical hyper-IgE syndromes (HIES) are caused by autosomal-dominant-negative (DN) variants of STAT3 (Signal Transducer And Activator Of Transcription 3) or IL6ST (Interleukin 6 Cytokine Family Signal Transducer), biallelic partial loss-of-function (LOF) variants of IL6ST, or biallelic complete LOF variants of ZNF341 (Zinc Finger Protein 341). Including the two new cases described in this review, only 20 patients with autosomal-recessive (AR) ZNF341 deficiency have ever been reported. Patients with AR ZNF341 deficiency have clinical and immunological phenotypes resembling those of patients with autosomal-dominant STAT3 deficiency, but with a usually milder clinical presentation and lower NK (Natural Killer) cell counts...
April 18, 2023: Current Opinion in Immunology
https://read.qxmd.com/read/36958512/changes-in-cytokine-and-cytokine-receptor-levels-during-postnatal-development-of-the-human-dorsolateral-prefrontal-cortex
#24
JOURNAL ARTICLE
Rachel E H Sager, Adam K Walker, Frank Middleton, Kate Robinson, Maree J Webster, Karen Gentile, Ma-Li Wong, Cynthia Shannon Weickert
In addition to their traditional roles in immune cell communication, cytokines regulate brain development. Cytokines are known to influence neural cell generation, differentiation, maturation, and survival. However, most work on the role of cytokines in brain development investigates rodents or focuses on prenatal events. Here, we investigate how mRNA and protein levels of key cytokines and cytokine receptors change during postnatal development in the human prefrontal cortex. We find that most cytokine transcripts investigated (IL1B, IL18, IL6, TNF, IL13) are lowest at birth and increase between 1...
March 21, 2023: Brain, Behavior, and Immunity
https://read.qxmd.com/read/36810097/the-alzheimer-s-disease-linked-protease-bace1-modulates-neuronal-il-6-signaling-through-shedding-of-the-receptor-gp130
#25
JOURNAL ARTICLE
Stephan A Müller, Merav D Shmueli, Xiao Feng, Johanna Tüshaus, Neele Schumacher, Ryan Clark, Brad E Smith, An Chi, Stefan Rose-John, Matthew E Kennedy, Stefan F Lichtenthaler
BACKGROUND: The protease BACE1 is a major drug target for Alzheimer's disease, but chronic BACE1 inhibition is associated with non-progressive cognitive worsening that may be caused by modulation of unknown physiological BACE1 substrates. METHODS: To identify in vivo-relevant BACE1 substrates, we applied pharmacoproteomics to non-human-primate cerebrospinal fluid (CSF) after acute treatment with BACE inhibitors. RESULTS: Besides SEZ6, the strongest, dose-dependent reduction was observed for the pro-inflammatory cytokine receptor gp130/IL6ST, which we establish as an in vivo BACE1 substrate...
February 21, 2023: Molecular Neurodegeneration
https://read.qxmd.com/read/36731227/mir-223-3p-mediates-the-diabetic-kidney-disease-progression-by-targeting-il6st-stat3-pathway
#26
JOURNAL ARTICLE
Ping Tang, Yushan Xu, Jingrong Zhang, Juanli Nan, Ruxian Zhong, Jingmei Luo, Dazhi Xu, Shaoqing Shi, Lihua Zhang
Diabetic kidney disease (DKD), the most pervasive complication in diabetic patients, has become a major health threat to the aging population. Our previous miRNA profiling identified hsa-miR-223-3p as a dysregulated miRNA in the DKD samples, which may serve as a biomarker for DKD diagnosis. However, the specific mechanism of miR-223-3p in the pathogenesis of DKD remains to be elucidated. In this study, we first verified that miR-223-3p level was significantly decreased in the in vitro cell model and in vivo db/db DKD model, accompanied with endothelial cell damage...
January 21, 2023: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/36674945/%C3%AE-synuclein-induces-neuroinflammation-injury-through-the-il6st-as-stat3-hif-1%C3%AE-axis
#27
JOURNAL ARTICLE
Danyu Lin, Han Zhang, Jieli Zhang, Kaixun Huang, Ying Chen, Xiuna Jing, Enxiang Tao
The aggregation of α-synuclein (α-syn) promotes neuroinflammation and neuronal apoptosis, which eventually contribute to the pathogenesis of Parkinson's disease (PD). Our microarray analysis and experimental data indicated a significant expression difference of the long noncoding RNA IL6ST-AS and its anti-sense strand, IL6ST , in α-synuclein-induced microglia, compared with unstimulated microglia. IL6ST is a key component of the IL6R/IL6ST complex in the microglial membrane, which recognizes extracellular inflammatory factors, such as IL6...
January 11, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36646738/uterine-epithelial-gp130-orchestrates-hormone-response-and-epithelial-remodeling-for-successful-embryo-attachment-in-mice
#28
JOURNAL ARTICLE
Takafumi Namiki, Jumpei Terakawa, Harumi Karakama, Michiko Noguchi, Hironobu Murakami, Yoshinori Hasegawa, Osamu Ohara, Takiko Daikoku, Junya Ito, Naomi Kashiwazaki
Leukemia inhibitory factor (LIF) receptor, an interleukin 6 cytokine family signal transducer (Il6st, also known as Gp130) that is expressed in the uterine epithelium and stroma, has been recognized to play an essential role in embryo implantation. However, the molecular mechanism underlying Gp130-mediated LIF signaling in the uterine epithelium during embryo implantation has not been elucidated. In this study, we generated mice with uterine epithelium specific deletion of Gp130 (Gp130 ecKO). Gp130 ecKO females were infertile due to the failure of embryo attachment and decidualization...
January 16, 2023: Scientific Reports
https://read.qxmd.com/read/36572849/lc-ms-ms-based-metabolomics-and-proteomics-reveal-candidate-biomarkers-and-molecular-mechanism-of-early-iga-nephropathy
#29
JOURNAL ARTICLE
Di Zhang, Yaohan Li, Mingzhu Liang, Yan Liang, Jingkui Tian, Qiang He, Bingxian Yang, Juan Jin, Wei Zhu
BACKGROUND: Immunoglobulin A nephropathy (IgAN), a globally common primary chronic glomerulopathy, is one of the leading causes of end-stage renal disease. However, the underlying mechanisms of IgAN have yet to be demonstrated. There were no adequate and reliable plasma biomarkers for clinical diagnosis, especially at the early stage. In the present study, integrative proteomics and metabolomics were aimed at exploring the mechanism of IgAN and identifying potential biomarkers. METHODS: Plasma from IgAN and healthy individuals were collected and analyzed in a randomized controlled manner...
December 27, 2022: Clinical Proteomics
https://read.qxmd.com/read/36565897/variation-in-il6st-cytokine-family-function-and-the-potential-of-il6-trans-signalling-in-er%C3%AE-positive-breast-cancer-cells
#30
JOURNAL ARTICLE
Duniya Mosly, Kenneth MacLeod, Nicholas Moir, Arran Turnbull, Andrew H Sims, Simon P Langdon
High expression of the transmembrane receptor IL6ST (gp130) has been identified as a predictive biomarker of endocrine treatment response in ERα-positive breast cancers. To investigate its function further in this disease, this study evaluated the expression, function and signalling of IL6ST in ERα-positive breast cancer cell lines and investigated crosstalk between ERα and IL6ST. IL6ST was differentially expressed in ERα-positive breast cancer cell lines (low in MCF-7, high in ZR751 and T47D), while multiple soluble isoforms of IL6ST were identified...
December 21, 2022: Cellular Signalling
https://read.qxmd.com/read/36547062/somatic-mutations-alter-interleukin-signaling-pathways-in-grade-ii-invasive-breast-cancer-patients-an-egyptian-experience
#31
JOURNAL ARTICLE
Auhood Nassar, Abdel Rahman N Zekri, Mostafa H Elberry, Ahmed M Lymona, Mai M Lotfy, Mohamed Abouelhoda, Amira Salah El-Din Youssef
This study aimed to investigate the impact of somatic mutations on various interleukin signaling pathways associated with grade II invasive breast cancer (BC) in Egyptian patients to broaden our understanding of their role in promoting carcinogenesis. Fifty-five grade II invasive BC patients were included in this study. Data for somatic mutations in 45 BC patients were already available from a previous study. Data for somatic mutations of 10 new BC patients were included in the current study. Somatic mutations were identified using targeted next-generation sequencing (NGS) to study their involvement in interleukin signaling pathways...
November 26, 2022: Current Issues in Molecular Biology
https://read.qxmd.com/read/36504430/differential-expression-of-cd8-defines-phenotypically-distinct-cytotoxic-t-cells-in-cancer-and-multiple-sclerosis
#32
JOURNAL ARTICLE
Tobias Burkard, Martina Herrero San Juan, Caroline Dreis, Anastasiia Kiprina, Dmitry Namgaladze, Kai Siebenbrodt, Sebastian Luger, Christian Foerch, Josef M Pfeilschifter, Andreas Weigert, Heinfried H Radeke
BACKGROUND: Cytotoxic T lymphocytes take on a leading role in many immune-related diseases. They function as key effector immune cells fighting cancer cells, but they are also considerably involved in autoimmune diseases. Common to both situations, CD8+ T cells need to adapt their metabolism and effector function to the harsh and nutrient-deprived conditions of the disease-associated microenvironment. METHODS: We used an in vitro starvation as well as rapamycin treatment protocol mimicking nutrient deprivation to generate CD8Low versus CD8High T cells and performed FACS-Sorting followed by transcriptomic profiling of the cytotoxic T cell subsets...
December 2022: Clinical and Translational Medicine
https://read.qxmd.com/read/36435159/the-signal-transducer-and-activator-of-transcription-3-at-the-center-of-the-causative-gene-network-of-the-hyper-ige-syndrome
#33
REVIEW
Yoshiyuki Minegishi
The hyper-IgE syndrome (HIES) is characterized by atopic dermatitis with extremely high serum IgE levels and diminished inflammatory responses, in combination with bacterial and fungal infections followed by pneumatocele formation. These immunological manifestations are frequently associated with nonimmunological abnormalities, including characteristic face, pathological fracture, and retention of deciduous teeth. We previously identified that major causal variants of the HIES are dominant-negative variants in the signal transducer and activator of transcription 3 (STAT3) gene...
November 23, 2022: Current Opinion in Immunology
https://read.qxmd.com/read/36270072/srrm1-promotes-the-proliferation-migration-and-invasion-of-hepatocellular-carcinoma-cells-by-regulating-the-jak-stat-signaling-pathway
#34
JOURNAL ARTICLE
Xiaoyan Song, Jianhua Ma
BACKGROUND: To explore the regulatory effect of serine/arginine repetitive matrix 1 (SRRM1) on hepatocellular carcinoma (HCC) and its potential pathway. METHODS: SRRM1 level in the tissue was tested by western blot and immunohistochemistry. Cells proliferation, apoptosis, migration, and invasion were tested by EdU, flow cytometry, wound healing assay, and Transwell, respectively. The potential mechanism of SRRM1 was explored through GSEA enrichment analysis and GeneMANIA protein-protein interaction (PPI) network...
October 12, 2022: Tissue & Cell
https://read.qxmd.com/read/36257578/circubxn7-suppresses-cell-proliferation-and-facilitates-cell-apoptosis-in-lipopolysaccharide-induced-cell-injury-by-sponging-mir-622-and-regulating-the-il6st-jak1-stat3-axis
#35
JOURNAL ARTICLE
Fan Xu, Runnan Chen, Yue Shen, Hanhan Liu, Lijuan Hu, Lei Zhu
Acute respiratory distress syndrome (ARDS) is a common and serious respiratory illness with substantial morbidity and mortality. Circular RNAs have been demonstrated to participate in various diseases processes. However, the biological function and mechanism of most circular RNAs have not been elucidated in ARDS. In this study, we found that circUBXN7 was significantly increased in lipopolysaccharide (LPS)-induced A549 and Beas-2B cell injury. Inhibition of circUBXN7 significantly promoted cell proliferation and reduced cell apoptosis, while overexpression of circUBXN7 suppressed cell proliferation and accelerated cell apoptosis in LPS-induced A549 and Beas-2B cells...
October 15, 2022: International Journal of Biochemistry & Cell Biology
https://read.qxmd.com/read/36198739/protein-interaction-cytotoxic-transcriptomic-and-proteomic-responses-to-structurally-distinct-epac1-activators-in-huvecs
#36
JOURNAL ARTICLE
Jolanta Wiejak, Urszula Luchowska-Stańska, Pingyuan Wang, Jia Zhou, Pasquale Maffia, David Morgan, Graeme Barker, Stephen J Yarwood
The N-acylsulfonamide derivative, I942, represents the first non-cyclic nucleotide partial agonist of EPAC1. This was soon followed by the identification of the I942 analogues, PW0381, PW0521 and PWO577 and a series of benzofuran oxoacetic acid EPAC1 activators, SY006, SY007 and SY009. Protein interaction, cytotoxicity and EPAC1 activation assays applied here identify PWO577 and SY007 as being effective EPAC1 binders that are well tolerated in HUVECs at concentrations greater than 100 μM and up to 48 h incubation and are effective activators of transfected EPAC1 in U2OS cells...
October 5, 2022: Scientific Reports
https://read.qxmd.com/read/36061134/impact-of-single-nucleotide-polymorphism-in-the-ankrd55-gene-on-occurrence-and-clinical-characteristics-of-rheumatoid-arthritis
#37
JOURNAL ARTICLE
Rasoul Salehi, Mina Motaghi, Amirhossein Salehi, Hadi Karimzadeh, Bahram Pakzad
Background: Rheumatoid Arthritis (RA) has multifactorial etiology and numerous genetic and environmental factors have been related to an increased risk of RA. Recently, Genome-Wide Association Studies (GWAS) suggested a large number of Single Nucleotide Polymorphisms (SNPs) loci affecting the susceptibility to RA. One of these loci is rs6859219 (C>A), a functional polymorphism in the ANKRD55 gene which was associated with the expression of ANKRD55 and IL6ST . In the current study, we evaluated the possible association between rs6859219 (intronic variant) in the ANKRD55 gene with RA risk in the Iranian population...
July 2022: Avicenna Journal of Medical Biotechnology
https://read.qxmd.com/read/36054964/exogenous-oncostatin-m-induces-cardiac-dysfunction-musculoskeletal-atrophy-and-fibrosis
#38
JOURNAL ARTICLE
Daenique H A Jengelley, Meijing Wang, Ashok Narasimhan, Joseph E Rupert, Andrew R Young, Xiaoling Zhong, Daniel J Horan, Alexander G Robling, Leonidas G Koniaris, Teresa A Zimmers
Musculoskeletal diseases such as muscular dystrophy, cachexia, osteoarthritis, and rheumatoid arthritis impair overall physical health and reduce survival. Patients suffer from pain, dysfunction, and dysmobility due to inflammation and fibrosis in bones, muscles, and joints, both locally and systemically. The Interleukin-6 (IL-6) family of cytokines, most notably IL-6, is implicated in musculoskeletal disorders and cachexia. Here we show elevated circulating levels of OSM in murine pancreatic cancer cachexia and evaluate the effects of the IL-6 family member, Oncostatin M (OSM), on muscle and bone using adeno-associated virus (AAV) mediated over-expression of murine OSM in wildtype and IL-6 deficient mice...
August 30, 2022: Cytokine
https://read.qxmd.com/read/36045041/temporal-variability-in-inflammatory-gene-methylation-and-delirium-in-critically-ill-patients
#39
JOURNAL ARTICLE
Sheila A Alexander, Yvette P Conley, Timothy D Girard, Bryan J McVerry, Dianxu Ren
BACKGROUND: Intensive care unit (ICU) delirium is associated with a proinflammatory state and poor outcomes. An epigenetic mechanism may modify inflammation. OBJECTIVE: To identify inflammatory gene methylation trajectory groups and explore their clinical and demographic variability. METHODS: Patients were at least 18 years old; received mechanical ventilation for at least 24 hours; had no brain disorder/injury, preexisting dementia, or positive toxicology screen; and were admitted to a medical or surgical/trauma ICU...
September 1, 2022: American Journal of Critical Care
https://read.qxmd.com/read/35929062/activation-of-the-jak1-stat1-signaling-pathway-is-associated-with-peroxiredoxin-6-expression-levels-in-human-epididymis-epithelial-cells
#40
JOURNAL ARTICLE
Hui Shi, Xiaoyu Liu, Yanwei Wang, Haiyan Wang, Bochen Pan, Jianyuan Li
INTRODUCTION: Peroxiredoxin 6 (Prdx6) is widely expressed in mammalian tissues. Our previous study demonstrated that Prdx6 was expressed in human epididymis, present in human seminal fluid, and in spermatozoa. The protective role of Prdx6 in maintaining the viability and DNA integrity of human spermatozoa was also detected. Here, we demonstrate the potential role and mechanism of Prdx6 in human epididymis epithelial cells (HEECs). MATERIAL AND METHODS: Western blotting was used to measure expression levels of key proteins in the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway...
August 5, 2022: Folia Histochemica et Cytobiologica
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