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https://www.readbyqxmd.com/read/28412025/the-influence-of-chronic-il-6-exposure-in-vivo-on-rat-achilles-tendon-extracellular-matrix
#1
Mark S Katsma, Shivam H Patel, Erica Eldon, Kathryn A Corbell, Kevin L Shimkus, James D Fluckey, Chad C Carroll
When compared to placebo, acetaminophen (APAP) reduces tendon stiffness and collagen cross-linking. APAP also enhances the exercise-induced increase in peritendinous levels of IL-6. Elevated levels of IL-6 are associated with tendinopathy, thus we hypothesized that chronic, elevated peritendinous IL-6 would alter tendon extracellular matrix (ECM). IL-6 (∼3000pgml(-1)) was injected (3dwk(-1) for 8-wks) into the Achilles peritendinous region of male Wistar rats (n=16) with the opposite leg serving as a sham...
April 13, 2017: Cytokine
https://www.readbyqxmd.com/read/28370781/downregulation-of-genes-related-to-immune-and-inflammatory-response-in-ivf-implantation-failure-cases-under-controlled-ovarian-stimulation
#2
Amruta D S Pathare, Kusum Zaveri, Indira Hinduja
PROBLEM: Implantation failure (IF) even after the good-quality embryo transfer (ET) is main obstacle in in vitro fertilization (IVF). We aim to study the genomics of endometrial receptivity in IF patients under controlled ovarian stimulation (COS) during which ET is generally practised in IVF. METHOD OF STUDY: Endometrial gene expression profiling in IF patients (n=10) and oocyte donors (n=8) were compared during window of implantation under COS by microarray. Enrichment analysis of microarray data was performed to determine dysregulated pathways...
March 30, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28323122/exome-analysis-of-the-evolutionary-path-of-hepatocellular-adenoma-carcinoma-transition-vascular-invasion-and-brain-dissemination
#3
Sílvia Vilarinho, Zeynep Erson-Omay, Kisha Mitchell-Richards, Charles Cha, Carol Nelson-Williams, Akdes Serin Harmancı, Katsuhito Yasuno, Murat Günel, Tamar H Taddei
Hepatocellular adenoma (HCA) is a rare benign liver tumor, predominantly seen in young women. Its major complications are malignant transformation, spontaneous hemorrhage, and rupture. We describe a case of a young female with no underlying liver disease who presented with acute abdominal pain and was found to have a 17 cm heterogeneous mass in the left lobe of the liver. She underwent left hepatectomy and pathology revealed a 14 cm moderately differentiated hepatocellular carcinoma (HCC) arising in a shell of a HCA...
March 17, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28260060/bioinformatics-analysis-on-the-differentiation-of-bone-mesenchymal-stem-cells-into-osteoblasts-and-adipocytes
#4
Xiaoyuan Xu, He Jiang, Xingnuan Li, Ping Wu, Jianyun Liu, Tao Wang, Xiaoou Zhou, Jianjun Xiong, Weidong Li
The present study aimed to screen several differentially expressed genes (DEGs) and differentially expressed microRNAs (miRNAs) for two types of mesenchymal stem cell (MSC) differentiation. Bone morphogenetic protein 6 (BMP‑6) and dexamethasone were used to induce MSCs towards osteoblastic differentiation or adipocytic differentiation. The t‑test in the Bioconductor bioinformatics software tool was used to screen DEGs and differentially expressed miRNAs in the two samples. Subsequent gene ontology (GO) and pathway analyses on the DEGs were performed using the GO and Kyoto Encyclopedia of Genes and Genomes databases, respectively; potential target genes for the screened miRNAs were predicted using the TargetScan database...
April 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28202235/stx12-lncrna-mir-148a-smad5-participate-in-the-regulation-of-pancreatic-stellate-cell-activation-through-a-mechanism-involving-competing-endogenous-rna
#5
Hao Wang, Yanfeng Jiang, Ming Lu, Bei Sun, Xin Qiao, Dongbo Xue, Weihui Zhang
BACKGROUND: With the deepening of research, the roles of LncRNAs play in the fibrotic process have attracted great attention. At the early stage of pancreatic fibrogenesis, to effectively regulate pancreatic stellate cells (PSCs) activation is crucial for the treatment of chronic pancreatic fibrosis. METHODS: Microarray data on chronic pancreatitis were retrieved from the Gene Expression Omnibus (GEO) repository and analyzed using bioinformatic methods. A diagram of the lncRNA-miRNA-mRNA ceRNA network was constructed...
February 1, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28130546/yap-il-6st-autoregulatory-loop-activated-on-apc-loss-controls-colonic-tumorigenesis
#6
Koji Taniguchi, Toshiro Moroishi, Petrus R de Jong, Michal Krawczyk, Britta Moyo Grebbin, Huiyan Luo, Rui-Hua Xu, Nicole Golob-Schwarzl, Caroline Schweiger, Kepeng Wang, Giuseppe Di Caro, Ying Feng, Eric R Fearon, Eyal Raz, Lukas Kenner, Henner F Farin, Kun-Liang Guan, Johannes Haybaeck, Christian Datz, Kang Zhang, Michael Karin
Loss of tumor suppressor adenomatous polyposis coli (APC) activates β-catenin to initiate colorectal tumorigenesis. However, β-catenin (CTNNB1) activating mutations rarely occur in human colorectal cancer (CRC). We found that APC loss also results in up-regulation of IL-6 signal transducer (IL-6ST/gp130), thereby activating Src family kinases (SFKs), YAP, and STAT3, which are simultaneously up-regulated in the majority of human CRC. Although, initial YAP activation, which stimulates IL6ST gene transcription, may be caused by reduced serine phosphorylation, sustained YAP activation depends on tyrosine phosphorylation by SFKs, whose inhibition, along with STAT3-activating JAK kinases, causes regression of established colorectal tumors...
February 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27939373/molecular-classification-of-hepatocellular-adenoma-associates%C3%A2-with-risk-factors-bleeding-and-malignant-transformation
#7
Jean Charles Nault, Gabrielle Couchy, Charles Balabaud, Guillaume Morcrette, Stefano Caruso, Jean-Frederic Blanc, Yannick Bacq, Julien Calderaro, Valérie Paradis, Jeanne Ramos, Jean-Yves Scoazec, Viviane Gnemmi, Nathalie Sturm, Catherine Guettier, Monique Fabre, Eric Savier, Laurence Chiche, Philippe Labrune, Janick Selves, Dominique Wendum, Camilla Pilati, Alexis Laurent, Anne De Muret, Brigitte Le Bail, Sandra Rebouissou, Sandrine Imbeaud, Paulette Bioulac-Sage, Eric Letouzé, Jessica Zucman-Rossi
BACKGROUND & AIMS: Hepatocellular adenomas (HCAs) are benign liver tumors that can be assigned to molecular subtypes based on inactivating mutations in hepatocyte nuclear factor 1A, activating mutations in β-catenin, or activation of inflammatory signaling pathways. We aimed to update the classification system for HCA and associate the subtypes with disease risk factors and complications. METHODS: We analyzed expression levels of 20 genes and sequenced exon regions of 8 genes (HNF1A, IL6ST, CTNNB1, FRK, STAT3, GNAS, JAK1, and TERT) in 607 samples of 533 HCAs from 411 patients, collected from 28 centers mainly in France from 2000 and 2014...
December 7, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27821646/protein-and-glycomic-plasma-markers-for-early-detection-of-adenoma-and-colon-cancer
#8
Jung-Hyun Rho, Jon J Ladd, Christopher I Li, John D Potter, Yuzheng Zhang, David Shelley, David Shibata, Domenico Coppola, Hiroyuki Yamada, Hidenori Toyoda, Toshifumi Tada, Takashi Kumada, Dean E Brenner, Samir M Hanash, Paul D Lampe
OBJECTIVE: To discover and confirm blood-based colon cancer early-detection markers. DESIGN: We created a high-density antibody microarray to detect differences in protein levels in plasma from individuals diagnosed with colon cancer <3 years after blood was drawn (ie, prediagnostic) and cancer-free, matched controls. Potential markers were tested on plasma samples from people diagnosed with adenoma or cancer, compared with controls. Components of an optimal 5-marker panel were tested via immunoblotting using a third sample set, Luminex assay in a large fourth sample set and immunohistochemistry (IHC) on tissue microarrays...
November 7, 2016: Gut
https://www.readbyqxmd.com/read/27571132/leukemia-inhibitory-factor-is-necessary-for-ovulation-in-female-rhesus-macaques
#9
Melinda J Murphy, Nathan G Halow, Pamela A Royer, Jon D Hennebold
Although the requirement of pituitary-derived LH for ovulation is well documented, the intrafollicular paracrine and autocrine processes elicited by LH necessary for follicle rupture are not fully understood. Evaluating a published rhesus macaque periovulatory transcriptome database revealed that mRNA encoding leukemia inhibitory factor (LIF) and its downstream signaling effectors are up-regulated in the follicle after animals receive an ovulatory stimulus (human chorionic gonadotropin [hCG]). Follicular LIF mRNA and protein levels are below the limit of detection before the administration of hCG but increase significantly 12 hours thereafter...
November 2016: Endocrinology
https://www.readbyqxmd.com/read/27492538/enhanced-lps-induced-activation-of-il-27-signalling-in-sarcoidosis
#10
Sabine Ringkowski, Joshua Loke, Shuying Huang, Hasib Ahmadzai, Felix J F Herth, Paul S Thomas, Cristan Herbert
RATIONALE: Granulomas in sarcoidosis have recently been described as containing Interleukin (IL)-27, one of the members of the IL-12 family of cytokines, which also includes IL-35. Levels of these cytokines and the IL-27 receptor subunits were hypothesised to differ between patients with sarcoidosis compared to healthy controls in peripheral blood. METHODS: Using a cross-sectional study design, plasma and peripheral blood mononuclear cells (PBMC) were collected from patients and control subjects...
August 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27387064/human-cytomegalovirus-immediate-early-1-protein-rewires-upstream-stat3-to-downstream-stat1-signaling-switching-an-il6-type-to-an-ifn%C3%AE-like-response
#11
Thomas Harwardt, Simone Lukas, Marion Zenger, Tobias Reitberger, Daniela Danzer, Theresa Übner, Diane C Munday, Michael Nevels, Christina Paulus
The human cytomegalovirus (hCMV) major immediate-early 1 protein (IE1) is best known for activating transcription to facilitate viral replication. Here we present transcriptome data indicating that IE1 is as significant a repressor as it is an activator of host gene expression. Human cells induced to express IE1 exhibit global repression of IL6- and oncostatin M-responsive STAT3 target genes. This repression is followed by STAT1 phosphorylation and activation of STAT1 target genes normally induced by IFNγ...
July 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27384491/the-mitochondrial-derived-peptide-humanin-activates-the-erk1-2-akt-and-stat3-signaling-pathways-and-has-age-dependent-signaling-differences-in-the-hippocampus
#12
Su-Jeong Kim, Noel Guerrero, Gabriella Wassef, Jialin Xiao, Hemal H Mehta, Pinchas Cohen, Kelvin Yen
Humanin is a small secreted peptide that is encoded in the mitochondrial genome. Humanin and its analogues have a protective role in multiple age-related diseases including type 2 diabetes and Alzheimer's disease, through cytoprotective and neuroprotective effects both in vitro and in vivo. However, the humanin-mediated signaling pathways are not well understood. In this paper, we demonstrate that humanin acts through the GP130/IL6ST receptor complex to activate AKT, ERK1/2, and STAT3 signaling pathways. Humanin treatment increases phosphorylation in AKT, ERK 1/2, and STAT3 where PI3K, MEK, and JAK are involved in the activation of those three signaling pathways, respectively...
July 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27242532/ep300-protects-from-light-induced-retinopathy-in-zebrafish
#13
Reiko Kawase, Yuhei Nishimura, Yoshifumi Ashikawa, Shota Sasagawa, Soichiro Murakami, Mizuki Yuge, Shiko Okabe, Koki Kawaguchi, Hiroshi Yamamoto, Kazumi Moriyuki, Shinsaku Yamane, Kazuhiro Tsuruma, Masamitsu Shimazawa, Hideaki Hara, Toshio Tanaka
Exposure of rhodopsin to bright white light can induce photoreceptor cell damage and degeneration. However, a comprehensive understanding of the mechanisms underlying light-induced retinopathy remains elusive. In this study, we performed comparative transcriptome analysis of three rodent models of light-induced retinopathy, and we identified 37 genes that are dysregulated in all three models. Gene ontology analysis revealed that this gene set is significantly associated with a cytokine signaling axis composed of signal transducer and activator of transcription 1 and 3 (STAT1/3), interleukin 6 signal transducer (IL6ST), and oncostatin M receptor (OSMR)...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27053681/socs3-modulates-the-response-to-enzalutamide-and-is-regulated-by-androgen-receptor-signaling-and-cpg-methylation-in-prostate-cancer-cells
#14
Florian Handle, Holger H H Erb, Birgit Luef, Julia Hoefer, Dimo Dietrich, Walther Parson, Glen Kristiansen, Frédéric R Santer, Zoran Culig
UNLABELLED: The proinflammatory cytokine IL6 is associated with bad prognosis in prostate cancer and implicated in progression to castration resistance. Suppressor of cytokine signaling 3 (SOCS3) is an IL6-induced negative feedback regulator of the IL6/Janus kinase (JAK)/STAT3 pathway. This study reveals that the SOCS3 promoter is hypermethylated in cancerous regions compared with adjacent benign tissue in prostate cancer using methylation-specific qPCR. A series of in vitro experiments was performed to assess the functional impact of low SOCS3 expression during anti-androgen treatment...
June 2016: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/27003603/loss-of-p53-function-activates-jak2-stat3-signaling-to-promote-pancreatic-tumor-growth-stroma-modification-and%C3%A2-gemcitabine-resistance-in-mice-and-is-associated-with%C3%A2-patient-survival
#15
Sonja M Wörmann, Liang Song, Jiaoyu Ai, Kalliope N Diakopoulos, Magdalena U Kurkowski, Kivanc Görgülü, Dietrich Ruess, Andrew Campbell, Claudio Doglioni, Duncan Jodrell, Albrecht Neesse, Ihsan E Demir, Angelica-Phaedra Karpathaki, Maxim Barenboim, Thorsten Hagemann, Stefan Rose-John, Owen Sansom, Roland M Schmid, Maria P Protti, Marina Lesina, Hana Algül
BACKGROUND & AIMS: One treatment strategy for pancreatic ductal adenocarcinoma is to modify, rather than deplete, the tumor stroma. Constitutive activation of the signal transducer and activator of transcription 3 (STAT3) is associated with progression of pancreatic and other solid tumors. We investigated whether loss of P53 function contributes to persistent activation of STAT3 and modification of the pancreatic tumor stroma in patients and mice. METHODS: Stat3, Il6st (encodes gp130), or Trp53 were disrupted, or a mutant form of P53 (P53R172H) or transgenic sgp130 were expressed, in mice that developed pancreatic tumors resulting from expression of activated KRAS (KrasG12D, KC mice)...
July 2016: Gastroenterology
https://www.readbyqxmd.com/read/26999096/proteomic-profiling-of-iron-overload-induced-human-hepatic-cells-reveals-activation-of-tlr2-mediated-inflammatory-response
#16
Xiang Li, Shiwei Li, Mize Lu, Guohua Yang, Yunfeng Shen, Xin Zhou
BACKGROUND: Hepatic iron overload is common in patients who have undergone hematopoietic cell transplantation (HCT) and may predispose to peri- and post-HCT toxicity. To better reveal more molecules that might be involved in iron overload-induced liver injury, we utilized proteomics to investigate differentially expressed proteins in iron overload-induced hepatocytes vs. untreated hepatocytes. METHODS AND RESULTS: HH4 hepatocytes were exposed to ferric ammonium citrate (FAC) to establish an in vitro iron overload model...
March 17, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/26969735/repurposing-the-crispr-cas9-system-for-targeted-dna-methylation
#17
Aleksandar Vojta, Paula Dobrinić, Vanja Tadić, Luka Bočkor, Petra Korać, Boris Julg, Marija Klasić, Vlatka Zoldoš
Epigenetic studies relied so far on correlations between epigenetic marks and gene expression pattern. Technologies developed for epigenome editing now enable direct study of functional relevance of precise epigenetic modifications and gene regulation. The reversible nature of epigenetic modifications, including DNA methylation, has been already exploited in cancer therapy for remodeling the aberrant epigenetic landscape. However, this was achieved non-selectively using epigenetic inhibitors. Epigenetic editing at specific loci represents a novel approach that might selectively and heritably alter gene expression...
July 8, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/26904154/standardized-scalp-massage-results-in-increased-hair-thickness-by-inducing-stretching-forces-to-dermal-papilla-cells-in-the-subcutaneous-tissue
#18
Taro Koyama, Kazuhiro Kobayashi, Takanori Hama, Kasumi Murakami, Rei Ogawa
OBJECTIVE: In this study, we evaluated the effect of scalp massage on hair in Japanese males and the effect of stretching forces on human dermal papilla cells in vitro. METHODS: Nine healthy men received 4 minutes of standardized scalp massage per day for 24 weeks using a scalp massage device. Total hair number, hair thickness, and hair growth rate were evaluated. The mechanical effect of scalp massage on subcutaneous tissue was analyzed using a finite element method...
2016: Eplasty
https://www.readbyqxmd.com/read/26837764/stomach-specific-activation-of-oncogenic-kras-and-stat3-dependent-inflammation-cooperatively-promote-gastric-tumorigenesis-in-a-preclinical-model
#19
Stefan Thiem, Moritz F Eissmann, Joachim Elzer, Anna Jonas, Tracy L Putoczki, Ashleigh Poh, Paul Nguyen, Adele Preaudet, Dustin Flanagan, Elizabeth Vincan, Paul Waring, Michael Buchert, Andrew Jarnicki, Matthias Ernst
About 5% to 10% of human gastric tumors harbor oncogenic mutations in the KRAS pathway, but their presence alone is often insufficient for inducing gastric tumorigenesis, suggesting a requirement for additional mutagenic events or microenvironmental stimuli, including inflammation. Assessing the contribution of such events in preclinical mouse models requires Cre recombinase-mediated conditional gene expression in stem or progenitor cells of normal and transformed gastric epithelium. We therefore constructed a bacterial artificial chromosome containing transgene (Tg), comprising the regulatory elements of the trefoil factor 1 (Tff1) gene and the tamoxifen-inducible Cre recombinase (CreERT2)-coding sequence...
April 15, 2016: Cancer Research
https://www.readbyqxmd.com/read/26825461/rbm3-regulates-temperature-sensitive-mir-142-5p-and-mir-143-thermomirs-which-target-immune-genes-and-control-fever
#20
Justin J-L Wong, Amy Y M Au, Dadi Gao, Natalia Pinello, Chau-To Kwok, Annora Thoeng, Katherine A Lau, Jane E A Gordon, Ulf Schmitz, Yue Feng, Trung V Nguyen, Robert Middleton, Charles G Bailey, Jeff Holst, John E J Rasko, William Ritchie
Fever is commonly used to diagnose disease and is consistently associated with increased mortality in critically ill patients. However, the molecular controls of elevated body temperature are poorly understood. We discovered that the expression of RNA-binding motif protein 3 (RBM3), known to respond to cold stress and to modulate microRNA (miRNA) expression, was reduced in 30 patients with fever, and in THP-1-derived macrophages maintained at a fever-like temperature (40 °C). Notably, RBM3 expression is reduced during fever whether or not infection is demonstrable...
April 7, 2016: Nucleic Acids Research
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