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"gastroesophageal reflux" and PPI and hoarseness

Valentin Becker, Stefan Grotz, Christoph Schlag, Simon Nennstiel, Analena Beitz, Bernhard Haller, Roland M Schmid, Alexander Meining, Monther Bajbouj
AIM: To identify objective and subjective predictors for the reliable diagnosis of gastroesophageal reflux disease (GERD) and the response to proton pump inhibitor (PPI) therapy. METHODS: Retrospectively, 683 consecutive patients suspected for GERD who underwent pH-metry/impedance measurement (pH/MII) were analyzed. All patients had previously undergone standard PPI treatment (e.g., pantoprazole 40 mg/d or comparable). Four hundred sixty patients were at least 10 d off PPIs (group A), whereas 223 patients were analyzed during their ongoing PPI therapy (group B)...
April 14, 2014: World Journal of Gastroenterology: WJG
Brittany Weber, Joel E Portnoy, Andres Castellanos, Mary J Hawkshaw, Deborah Lurie, Philip O Katz, Robert T Sataloff
OBJECTIVES: Laryngopharyngeal reflux (LPR) is a pervasive disorder that may cause hoarseness, throat clearing, and other symptoms. These symptoms are particularly problematic in professional voice users. Proton pump inhibitors (PPIs) are the mainstay of current medical management for LPR but may be insufficient in managing some patients' symptoms. Laparoscopic Nissen fundoplication (LNF) is well established for treatment of gastroesophageal reflux disease with a high success rate, but its role in the treatment of LPR remains uncertain...
July 2014: Journal of Voice: Official Journal of the Voice Foundation
Nikki Johnston, Peter W Dettmar, Vicki Strugala, Jacqui E Allen, Walter W Chan
In patients with laryngopharygeal reflux (LPR), gastric contents exhibit retrograde flow into the upper aero-digestive tract, causing extraesophageal symptoms including chronic cough, hoarseness, indigestion, difficulty swallowing, globus pharyngis, and asthma. The following on laryngopharyngeal reflux includes commentaries on the use of patient-completed questionaires and anti-human pepsin antibodies and other non-invasive tests in diagnosis; the role of pepsin and acid in the etiologies of laryngeal cancers; and the application of proton pump inhibitor (PPI) therapy for the treatment of LPR...
October 2013: Annals of the New York Academy of Sciences
Anna Rydén, Hans Denison, Maria Karlsson, Nimish Vakil
OBJECTIVE: The Reflux Symptom Questionnaire 7-day recall (RESQ-7) was developed, in line with the US Food and Drug Administration (FDA) guidelines, to address the need for a patient-reported outcome (PRO) instrument assessing symptoms specifically in patients with gastroesophageal reflux disease (GERD) who are only partially responsive to proton pump inhibitor (PPI) therapy. MATERIALS AND METHODS: The RESQ-7 was constructed using patient interviews and expert consensus...
September 2013: Scandinavian Journal of Gastroenterology
Thierry Vallot, Philippe Ducrotte, Bruno Bour, Jean-Paul Jacques, Philippe Houcke, Jean-Dominique De Korwin, Alexandre Pariente, Philippe Aygalenq, Bogdana Coudsy, Frédéric Carrois, Léa Ricci, Stanislas Bruley des Varannes
AIMS: The primary objectives of this observatory were: (1) to assess the prevalence of extradigestive symptoms (EDS) (asthma, pharyngeal pain, chronic hoarseness, nocturnal breathlessness, chronic or nocturnal cough, non-cardiac chest pain) which are suspected of being associated with gastro-oesophageal reflux (GERD) in a population consulting in general practice; (2) to compare the diagnostic and therapeutic approach adopted initially and at follow-up to the recommendations of the French-Belgian Consensus Conference on adult GERD (1999)...
May 2013: La Presse Médicale
So Young Jo, Nayoung Kim, Ji Hwan Lim, Cheol Min Shin, Young Soo Park, Dong Ho Lee, Hyun Chae Jung
BACKGROUND/AIMS: To compare gastroesophageal reflux disease (GERD) symptoms and response to proton pump inhibitor (PPI) in patients with erosive esophagitis (EE), non-erosive reflux disease (NERD) or functional heartburn (FH) using GERD impact scale (GIS) questionnaire. METHODS: Total 126 patients with GERD symptoms were diagnosed as EE (n = 62), NERD (n = 34) and FH (n = 30) by endoscopy, 24-hour esophageal pH testing and Bernstein test, prospectively. Analysis of risk factors and GIS questionnaire for GERD symptoms and quality of life were performed before and 8 weeks after PPI treatment...
January 2013: Journal of Neurogastroenterology and Motility
Nicola de Bortoli, Andrea Nacci, Edoardo Savarino, Irene Martinucci, Massimo Bellini, Bruno Fattori, Linda Ceccarelli, Francesco Costa, Maria Gloria Mumolo, Angelo Ricchiuti, Vincenzo Savarino, Stefano Berrettini, Santino Marchi
AIM: To investigate the prevalence of gastroesophageal reflux disease (GERD) in patients with a laryngoscopic diagnosis of laryngopharyngeal reflux (LPR). METHODS: Between May 2011 and October 2011, 41 consecutive patients with laryngopharyngeal symptoms (LPS) and laryngoscopic diagnosis of LPR were empirically treated with proton pump inhibitors (PPIs) for at least 8 wk, and the therapeutic outcome was assessed through validated questionnaires (GERD impact scale, GIS; visual analogue scale, VAS)...
August 28, 2012: World Journal of Gastroenterology: WJG
M Bajbouj
Gastroesophageal reflux disease (GERD) is a frequent chronic disorder occurring in two forms: on the one hand, typical symptoms such as heartburn and acid regurgitation are seen, while on the other hand atypical (extraesophageal) symptoms such as chronic cough, hoarseness, recurrent sinusitis, globus sensations in the throat, a burning feeling on the tongue, dental erosions and the constant need to clear the throat can be associated with gastroesophageal reflux. The standard therapeutic medical procedure comprises the administration of acid-suppressive agents, proton pump inhibitors (PPI)...
March 2012: HNO
Bong Eun Lee, Gwang Ha Kim, Dong Yup Ryu, Dong Uk Kim, Jae Hoon Cheong, Dong Gun Lee, Geun Am Song
BACKGROUND/AIMS: Laryngopharyngeal symptoms of gastroesophageal reflux disease (GERD) such as globus sensation, hoarseness and chronic cough are becoming increasingly recognized. This study was aimed to investigate the diagnostic usefulness of combined dual channel multichannel intraluminal impedance (MII)/pH-metry in 'off-proton pump inhibitor (PPI)' patients with suspected laryngopharyngeal reflux. METHODS: Ninety-eight patients with laryngopharyngeal symptoms of GERD were included...
April 2010: Journal of Neurogastroenterology and Motility
Brent White, Louis O Jeansonne, Michael Cook, L Felipe Chavarriaga, E Adam Goldenberg, S Scott Davis, C Daniel Smith, Leena Khaitan, Edward Lin
BACKGROUND: Obese patients with gastroesophageal reflux disease (GERD) refractory to medical therapy are a challenging patient population as obesity is a preoperative predictor of failure after antireflux surgery. We therefore sought to evaluate outcomes using one of two commercially available endoluminal therapies in this population. METHODS: Consecutive obese patients (body mass index (BMI)>30) with GERD (DeMeester>14.5) undergoing either Plicator (NDO) or Stretta (Curon) were identified in our single-institution prospective database...
June 2009: Obesity Surgery
Sachin Pawar, Hyun J Lim, Matthew Gill, Timothy L Smith, Albert Merati, Robert J Toohill, Todd A Loehrl
BACKGROUND: Patients commonly present with complaints of postnasal drainage (PND) without objective evidence to support a sinonasal or infectious etiology. PND has been attributed to extra-esophageal reflux (EER), and an empiric trial of antireflux medication often is used to treat PND and associated symptoms. This study was performed to (1) evaluate the relationship between symptoms of EER and PND and (2) assess the efficacy of proton pump inhibitors (PPIs) in the management of PND. METHODS: Patients with a chief complaint of PND without objective evidence of sinonasal inflammatory disease were enrolled in a prospective, double-blinded, randomized placebo-controlled trial using rabeprazole, 20 mg, orally twice daily or placebo for 90 days...
November 2007: American Journal of Rhinology
Monther Bajbouj, Valentin Becker, Martin Neuber, Roland M Schmid, Alexander Meining
BACKGROUND: Globus sensations, hoarseness and chronic cough are suggested to be atypical manifestations of Gastroesophageal Reflux Disease (GERD). The aim of the study was to investigate whether combined pH-metry and multichannel intraluminal impedance monitoring increases the diagnostic yield. METHODS: 41 patients with atypical GERD symptoms were included in the study. Globus sensation was the dominant symptom in 23 patients (56.1%). The remaining 18 patients (43...
2007: Digestion
Seth M Cohen, C Gaelyn Garrett
OBJECTIVE/HYPOTHESIS: This study will test the hypothesis that proton pump inhibitor (PPI) use is prevalent among patients referred for hoarseness and will assess the ultimate diagnosis and factors associated with patients' voice outcomes. STUDY DESIGN: Retrospective review of patients in a tertiary care voice clinic. METHODS: Patients with a primary diagnosis of hoarseness, who were taking or had taken PPIs in the previous 2 months and referred to a tertiary care voice clinic, were identified...
February 2008: Laryngoscope
Maria Pina Dore, Antonietta Pedroni, Gianni M Pes, Emanouil Maragkoudakis, Vincenza Tadeu, Pietro Pirina, Giuseppe Realdi, Giuseppe Delitala, Hoda M Malaty
The effect of proton pump inhibitor (PPI) therapy on extraesophageal or atypical manifestations of gastroesophageal reflux disease (GERD) remains unclear. This study aimed to evaluate the prevalence of atypical manifestations in patients with acid reflux disease and the effect of PPI treatment. Patients with symptoms and signs suggestive of reflux were enrolled. Erosive esophagitis was stratified using the Los Angeles classification. Demographic data and symptoms were assessed using a questionnaire and included typical symptoms (heartburn, regurgitation, dysphagia, odynophagia), and atypical symptoms (e...
February 2007: Digestive Diseases and Sciences
O Reichel, H Hagedorn, A Berghaus
BACKGROUND: During the last decades an increased prevalence of reflux disease can be observed. Otolaryngologists play an increasing role in the treatment of patients suffering from laryngopharyngeal reflux (LPR). Typical symptoms for LPR are globus sensation, dysphagia, throat clearing, chronic cough and hoarseness. The most frequent laryngoscopic finding in patients suffering from LPR is a posterior commissure hypertrophy. LPR is confirmed by laryngoscopy, LPR-related laryngoscopy scoring, 24-hour dual-probe pH-monitoring, and by empiric trial with proton pump inhibitors (PPI)...
December 2006: Laryngo- Rhino- Otologie
D Jaspersen
Gastroesophageal reflux disease (GERD) is a common condition that affects about 20-30% of the adult population, presenting with a broad spectrum of symptoms and varying degrees of severity and frequency. Other manifestations are being increasingly recognized: the so-called ''extraesophageal'' manifestations, such as laryngitis, hoarseness, chronic cough, asthma, or non-cardiac chest pain. Epidemiological studies consistently demonstrate significant associations between pulmonary manifestations and GERD. Up to 50% of patients with an endoscopically proven esophagitis suffer from symptoms other than heartburn or acid regurgitation...
September 2006: Minerva Gastroenterologica e Dietologica
Zhao-shen Li, Xiao-rong Xu, Duo-wu Zou, Wei-fen Xie, Xiao-feng Yu, Xi-mei Chen, Yong Lin, Jun Xia, Feng-shang Zhu, Wu Wen, Tun Su
OBJECTIVE: The aim of this prospective multi-center study was to evaluate the clinical characteristics of extraesophageal reflux disorders (EED) in gastroesophageal reflux disease (GERD) patients and the therapeutic effect of proton pump inhibitor (PPI) on EED. METHODS: We investigated GERD patients in 4 hospitals in Shanghai in a same time period. These patients were diagnosed as GERD by finding reflux esophagitis (RE) on endoscopy or with abnormal reflux during 24 h esophageal pH monitoring...
January 2006: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
Tasneem F Ahmed, Farah Khandwala, Tom I Abelson, Douglas M Hicks, Joel E Richter, Claudio Milstein, Michael F Vaezi
OBJECTIVES: Ear, nose, and throat (ENT) physicians often diagnose gastroesophageal reflux disease (GERD)-related laryngitis on the basis of symptoms and laryngeal signs; and may refer patients to gastroenterologists who contend that many such patients do not have reflux. Because of this dichotomy we designed this study to assess the practice pattern differences among ENT physicians and gastroenterologists in relation to the diagnosis and treatment of patients with GERD-related laryngitis...
March 2006: American Journal of Gastroenterology
H Gräter
Gastroesophageal reflux disease (GERD) includes different manifestations of esophageal and extraesophageal affections, such as erosive reflux disease, Barrett's esophagus, laryngitis and even pulmonary diseases. Typical symptoms are heartburn and acid regurgitation, but there are a lot of atypical disturbances like hoarseness or chronic cough. Endoscopy is the most important diagnostic procedure for elderly patients and for those with atypical symptoms. Younger people without alarming symptoms can be tested for GERD by treatment with proton pump inhibitors (PPI)...
November 30, 2005: Praxis
Doron Zamir
Gastroesophageal reflux disease (GERD) is the most common disease of the gastrointestinal system. Heartburn, regurgitation, and dysphagia are the most common symptoms of GERD. However, chest pain, chronic cough, laryngitis, hoarseness, and other otolaryngologic manifestation can be the primary manifestations of the disease. Endoscopy, barium studies, and especially pH monitoring and therapeutic trials may help in establishing the diagnosis of GERD. The introduction of H2 antagonists and especially of proton pump inhibitors (PPI) has brought symptomatic relief in most patients...
October 2005: European Journal of Internal Medicine
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