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https://www.readbyqxmd.com/read/28530607/metabolic-and-rna-profiling-elucidates-proanthocyanidins-accumulation-in-aglianico-grape
#1
Alessandra Rinaldi, Clizia Villano, Carmine Lanzillo, Angelo Tamburrino, Michael Jourdes, Pierre-Louis Teissedre, Luigi Moio, Luigi Frusciante, Domenico Carputo, Riccardo Aversano
Aglianico grapes are known for their high content of proanthocyanidins (PAs), which are responsible for the astringency of wines derived from this cultivar. However, the accumulation of PAs and their genetic control during berry development remain largely unexplored. This work aimed to monitor astringency-causing PAs in Aglianico berries and correlate them with the expression of 14 key genes. Berries were collected during ripening and dissected in skins and seeds. PAs were fractionated and the content of total phenolics, flavans, anthocyanins, tannins reactive towards salivary proteins and tannin structural composition were evaluated...
October 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28507011/influence-of-diet-in-multiple-sclerosis-a-systematic-review
#2
REVIEW
M José Bagur, M Antonia Murcia, Antonia M Jiménez-Monreal, Josep A Tur, M Mar Bibiloni, Gonzalo L Alonso, Magdalena Martínez-Tomé
Nutrition is considered to be a possible factor in the pathogenesis of the neurological disease multiple sclerosis (MS). Nutrition intervention studies suggest that diet may be considered as a complementary treatment to control the progression of the disease; a systematic review of the literature on the influence of diet on MS was therefore conducted. The literature search was conducted by using Medlars Online International Literature (MEDLINE) via PubMed and Scopus. Forty-seven articles met the inclusion criteria...
May 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28502165/grape-seed-proanthocyanidin-inhibits-mucin-synthesis-and-viral-replication-by-suppression-of-ap-1-and-nf-%C3%AE%C2%BAb-via-p38-mapks-jnk-signaling-pathways-in-respiratory-syncytial-virus-infected-a549-cells
#3
Jin-Woo Lee, Young Il Kim, Chang-Nim Im, Sung Wan Kim, Su Jin Kim, Seoyeon Min, Yong Hoon Joo, Sung-Vin Yim, Namhyun Chung
Airway epithelial cells are often infected by respiratory syncytial virus (RSV), one of the most common causes of asthma, bronchiolitis, chronic obstructive pulmonary disease (COPD), and pneumonia. During the infection process, excessive mucins aggravate airway inflammation. However, the mechanism underlying RSV-induced airway hyperresponsiveness and inflammation is poorly understood. Furthermore, no reliable vaccines or drugs for antiviral therapy are available. In this study, the effect of the natural compound grape seed proanthocyanidin (GSP) on RSV-infected human airway epithelial cells A549 was evaluated...
May 15, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28500724/grape-seed-proanthocyanidin-extract-ameliorates-inflammation-and-adiposity-by-modulating-gut-microbiota-in-high-fat-diet-mice
#4
Wen Liu, Shaoqian Zhao, Jiqiu Wang, Juan Shi, Yingkai Sun, Weiqing Wang, Guang Ning, Jie Hong, Ruixin Liu
SCOPE: Obesity and associated metabolic complications is a worldwide public health issue. Gut microbiota has been recently linked to obesity and its related inflammation. In this study, we have explored the anti-inflammatory effect of grape seed proanthocyanindin extract (GSPE) in the high-fat diet (HFD)-induced obesity and identified the contribution of the gut microbiota to GSPE effects on metabolism. METHODS AND RESULTS: Mice were fed a normal diet and a high-fat diet with or without GSPE (300mg/kg body weight/day) by oral gavage for 7 weeks...
May 12, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28499242/potential-ameliorative-effects-of-grape-seed-derived-polyphenols-against-cadmium-induced-prostatic-deficits
#5
Yongfang Lei, Qian Chen, Jinglou Chen, Dong Liu
Grape (Vitis vinifera) is consumed as fruit and wine for people. In this study, rat model of prostatic deficits was induced by orally receiving 60mg/L cadmium chlorine (CdCl2) through drinking water for 20 weeks. Grape seed-derived polyphenols extract (GSP) was orally given for 20 weeks. Finally, the prostatic levels of E-cadherin, fibronectin, and α-smooth muscle actin were measured by immunohistochemical and qPCR analysis. The oxidative stress was measured by detecting the levels of malondialdehyde, nitric oxide, reduced glutathione/oxidized glutathione and enzymatic antioxidant status...
May 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28491066/robust-phylogeny-of-tetrastigma-vitaceae-based-on-ten-plastid-dna-regions-implications-for-infrageneric-classification-and-seed-character-evolution
#6
Sadaf Habib, Viet-Cuong Dang, Stefanie M Ickert-Bond, Jin-Long Zhang, Li-Min Lu, Jun Wen, Zhi-Duan Chen
Tetrastigma (Miq.) Planch. is one of the most species-rich genera of the economically and agronomically important grape family Vitaceae. It includes ca. 95 species widely distributed in the tropics and subtropics of Asia and Australia. Species of Tetrastigma exhibit great diversity in both vegetative and reproductive characters. Here we inferred a well-supported phylogeny of Tetrastigma based on ten chloroplast DNA regions with an expanded taxon sampling of 72 species and two varieties. Our molecular results support six major clades within Tetrastigma and the relationships among these clades were well-resolved...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28490118/study-of-phenolic-extractability-in-grape-seeds-by-means-of-atr-ftir-and-raman-spectroscopy
#7
Julio Nogales-Bueno, Berta Baca-Bocanegra, Abigail Rooney, José Miguel Hernández-Hierro, Hugh J Byrne, Francisco José Heredia
Near infrared hyperspectral imaging has been applied to grape seeds in order to select a representative subset of samples according to their spectral features in the 900-1700nm range. Afterwards, selected grape seeds have been classified according to their total phenol and flavanol extractabilities. In this way, samples were sorted in three different groups identified as low, medium and high extractability levels. In order to establish the chemical structures which can be responsible for the different extractabilities, vibrational spectroscopy has been applied to the non-extracted material after seed extractions...
October 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28473058/increased-cytokine-production-by-monocytes-from-human-subjects-who-consumed-grape-powder-was-not-mediated-by-differences-in-dietary-intake-patterns
#8
Susan J Zunino, Nancy L Keim, Darshan S Kelley, Ellen L Bonnel, Elaine C Souza, Janet M Peerson
Recently, in a randomized, double-blind crossover study, we reported that consumption of grape powder by obese human subjects increased the production of the proinflammatory cytokines interleukin (IL)-1β and IL-6 by peripheral blood monocytes after ex vivo stimulation with bacterial lipopolysaccharide compared with the placebo treatment. We hypothesized that dietary grape powder increased the production of these cytokines by stimulated monocytes. To test this hypothesis, we used 24-hour dietary recall data to determine if differences in dietary patterns played a role in increased cytokine production...
April 2017: Nutrition Research
https://www.readbyqxmd.com/read/28471235/mechanism-of-grape-seeds-extract-protection-against-paracetamol-renal-cortical-damage-in-male-albino-rats
#9
S M N Abdel-Hafez, R A Rifaai, W Y Abd Elzaher
OBJECTIVE: The aim of the study was to assess the possible protective role of grape seeds extract (GSE) in ameliorating the toxic effects of paracetamol overdose on the rat renal cortical tissue. BACKGROUND: Paracetamol is one of the widely used non-steroidal anti-inflammatory drugs (NSAIDs). Unfortunately, it was reported as the most common cause of toxic ingestion in the world. Grape seeds extract (GSE) is known to have a strong antioxidant and anti-inflammatory properties...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28450008/flavanol-plasma-bioavailability-is-affected-by-metabolic-syndrome-in-rats
#10
Maria Margalef, Zara Pons, Lisard Iglesias-Carres, Francisca Isabel Bravo, Begoña Muguerza, Anna Arola-Arnal
Flavanols, which exert several health benefits, are metabolized after ingestion. Factors such as the host physiological condition could affect the metabolism and bioavailability of flavanols, influencing their bioactivities. This study aimed to qualitatively evaluate whether a pathological state influenced flavanol plasma bioavailability. Standard and cafeteria (CAF) diet fed rats, a robust model of metabolic syndrome (MeS), were administered 1000mg/kg of flavanol enriched grape seed polyphenol extract (GSPE)...
September 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28447711/alleviative-effect-of-grape-seed-proanthocyanidin-extract-on-small-artery-vascular-remodeling-in-spontaneous-hypertensive-rats-via-inhibition-of-collagen-hyperplasia
#11
Ying Liang, Haiqing Gao, Jian Wang, Quanzhen Wang, Shaohua Zhao, Jun Zhang, Jie Qiu
Vascular remodeling is a primary contributor to the initiation and development of hypertension, which has a pathological association with subsequent multi-organ damage. Grape seed proanthocyanidin extracts (GSPE) exhibit protective cardiovascular effects, resulting from their anti‑oxidant and anti‑inflammatory properties. However, the function and mechanism underlying the effect of GSPE on small artery remodeling remain to be elucidated. The present study investigated the effect of GSPE on vascular remodeling in the mesenteric small arteries of spontaneous hypertensive rats (SHR)...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28412456/dietary-proanthocyanidins-prevent-ultraviolet-radiation-induced-non-melanoma-skin-cancer-through-enhanced-repair-of-damaged-dna-dependent-activation-of-immune-sensitivity
#12
REVIEW
Santosh K Katiyar, Harish C Pal, Ram Prasad
Numerous plant products have been used to prevent and manage a wide variety of diseases for centuries. These products are now considered as promising options for the development of more effective and less toxic alternatives to the systems of medicine developed primarily in developed countries in the modern era. Grape seed proanthocyanidins (GSPs) are of great interest due to their anti-carcinogenic effects that have been demonstrated using various tumor models including ultraviolet (UV) radiation-induced non-melanoma skin cancer...
April 12, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28403352/effects-of-grape-seed-extract-on-periodontal-disease-an-experimental-study-in-rats
#13
Feyza Otan Özden, Elif Eser Sakallioğlu, Umur Sakallioğlu, Bülent Ayas, Züleyha Erişgin
Objective: This study aimed to demonstrate the effect of grape seed extract (GSE) on periodontitis. Material and Methods: Ligature induced periodontitis was created in 40 rats and they were assigned to four equal groups. One group was fed laboratory diet (group A) while three groups received GSE additionally. Silk ligatures were placed around the cervical area of the mandibular first molars for four weeks to induce periodontitis. The GSE groups were reallocated regarding GSE consumption as: for two weeks before ligation (group B; totally eight weeks), from ligation to two weeks after removal of the ligature (group C; totally six weeks), and for two weeks from ligature removal (group D; totally two weeks)...
March 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28392021/encapsulation-of-grape-seed-extract-in-polylactide-microcapsules-for-sustained-bioactivity-and-time-dependent-release-in-dental-material-applications
#14
Mostafa Yourdkhani, Ariene Arcas Leme-Kraus, Berdan Aydin, Ana Karina Bedran-Russo, Scott R White
OBJECTIVE: To sustain the bioactivity of proanthocyanidins-rich plant-derived extracts via encapsulation within biodegradable polymer microcapsules. METHODS: Polylactide microcapsules containing grape seed extract (GSE) were manufactured using a combination of double emulsion and solvent evaporation techniques. Microcapsule morphology, size distribution, and cross-section were examined via scanning electron microscopy. UV-vis measurements were carried out to evaluate the core loading and encapsulation efficiency of microcapsules...
April 6, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28391711/phenolic-content-and-antioxidant-properties-of-seeds-from-different-grape-cultivars-grown-in-iran
#15
Vasigheh Sadat Mirbagheri, Ebrahim Alizadeh, Mostafa Yousef Elahi, Sedigheh Esmaeilzadeh Bahabadi
This study investigated the antioxidant activity and phenolic composition of seed extracts from three grape cultivars grown in Iran. Folin Ciocalteu method was used for the determination of the total phenolic contents and GC-MS was used for the analysis of phenolic compositions. 1,1-diphenyl-2-picrylhydrazyl (DPPH) method was used to evaluate the antioxidant activity. The highest and the lowest total phenolic contents of seed extract were found in the black and green grape, respectively. The content of individual phenols such as Frulic acid, Gentistic acid, Syringic acid, (+) Catechin, Chlorogenic acid and (-)- Epicatchin gallate was cultivars dependent...
April 10, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28376889/grape-seed-derived-procyanidins-alleviate-gout-pain-via-nlrp3-inflammasome-suppression
#16
Hai-Jiao Liu, Xiu-Xiu Pan, Bing-Qian Liu, Xuan Gui, Liang Hu, Chun-Yi Jiang, Yuan Han, Yi-Xin Fan, Yu-Lin Tang, Wen-Tao Liu
BACKGROUND: Gout is one of the common inflammatory arthritis which affects many people for inflicting unbearable pain. Macrophage-mediated inflammation plays an important role in gout. The uptake of monosodium urate (MSU) crystals by macrophages can lead to activation of NOD-like receptors containing a PYD 3 (NLRP3) inflammasome, thus accelerating interleukin (IL)-1β production. Reactive oxygen species (ROS) promoted development of the inflammatory process through NLRP3 inflammasome...
April 4, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28373675/grape-seed-proanthocyanidin-supplementation-reduces-adipocyte-size-and-increases-adipocyte-number-in-obese-rats
#17
A Pascual-Serrano, A Arola-Arnal, S Suárez-Garcia, F I Bravo, M Suárez, L Arola, C Bladé
OBJECTIVES: White adipose tissue (WAT) expands through hypertrophy (increased adipocyte size) and/or hyperplasia (increased adipocyte number). Hypertrophy has been associated with insulin resistance and dyslipidemia independently of body composition and fat distribution. In contrast, hyperplasia protects against metabolic alterations. Proanthocyanidins, which are the most abundant flavonoids in the human diet, improve metabolic disturbances associated with diet-induced obesity without reducing body weight or adiposity...
April 4, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28369525/the-mads-box-gene-agamous-like-11-is-essential-for-seed-morphogenesis-in-grapevine
#18
Jaiana Malabarba, Vanessa Buffon, Jorge E A Mariath, Marcos L Gaeta, Marcelo C Dornelas, Márcia Margis-Pinheiro, Giancarlo Pasquali, Luís F Revers
Despite the wide appreciation of seedless grapes, little is known about the molecular mechanisms that drive the stenospermocarpic seedless-type phenotype in grapevine. In order to address the molecular mechanisms that control seedlessness in grapevine, our study aimed to characterize VviAGL11, a class D MADS-box transcription factor gene that has been proposed as the major candidate gene involved in Vitis vinifera seed morphogenesis. VviAGL11 allelic variations in seeded and seedless grapevine cultivars were determined, and its correlations with allele-specific steady-state mRNA levels were investigated...
March 1, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28351770/2d-nmr-investigation-and-in%C3%A2-vitro-evaluation-of-antioxidant-antigenotoxic-and-estrogenic-antiestrogenic-activities-of-strawberry-grape
#19
Brigida D'Abrosca, Margherita Lavorgna, Monica Scognamiglio, Chiara Russo, Vittoria Graziani, Concetta Piscitelli, Antonio Fiorentino, Marina Isidori
Strawberry grape is considered beneficial due to its extensive phytochemical properties. To expand the knowledge about the chemical constituents and the biological activities of the whole plant, 2D-NMR investigation has been carried out on pulp, peel, seeds, stalks and leaves. Catechin and epicatechin were identified as the main constituents of the seed extract, quercetin and ferulic acid were detected in the leaves and malvidin and cyanidin glucopyranoside in the peels. The leaf, stalk and seed extracts were found to be very rich in phytochemicals and were tested for their ability to reduce the mutagenicity and genotoxicity of standard agents via Salmonella mutagenicity assay and SOS chromotest, respectively...
March 27, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28344907/grape-seed-proanthocyanidin-extract-protects-lymphocytes-against-histone-induced-apoptosis
#20
Ping Chang, Bing Mo, David M Cauvi, Ying Yu, Zhenhui Guo, Jian Zhou, Qiong Huang, Qitao Yan, Guiming Chen, Zhanguo Liu
Apoptosis of lymphocytes is associated with immunosuppression and poor prognosis in sepsis. Our previous report showed that histones, nuclear proteins released from damaged or dying cells in sepsis, can mediate lymphocyte apoptosis via mitochondria damage. Grape seed proanthocyanidin extract (GSPE), a natural substance with protective properties against oxidative stress, plays a vital role in cell and mitochondria protection. We thus hypothesized that GSPE may play a protective role in histone-induced lymphocyte apoptosis through its anti-oxidative properties...
2017: PeerJ
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