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https://www.readbyqxmd.com/read/29158566/graphene-quantum-dots-for-cell-proliferation-nucleus-imaging-and-photoluminescent-sensing-applications
#1
Mukesh Kumar Kumawat, Mukeshchand Thakur, Raju B Gurung, Rohit Srivastava
We report a simple one-pot microwave assisted "green synthesis" of Graphene Quantum Dots (GQDs) using grape seed extract as a green therapeutic carbon source. These GQDs readily self-assemble, hereafter referred to as "self-assembled" GQDs (sGQDs) in the aqueous medium. The sGQDs enter via caveolae and clathrin-mediated endocytosis and target themselves into cell nucleus within 6-8 h without additional assistance of external capping/targeting agent. The tendency to self-localize themselves into cell nucleus also remains consistent in different cell lines such as L929, HT-1080, MIA PaCa-2, HeLa, and MG-63 cells, thereby serving as a nucleus labelling agent...
November 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29152654/nephrin-loss-is-reduced-by-grape-seed-proanthocyanidins-in-the-experimental-diabetic-nephropathy-rat-model
#2
Xianhua Li, Zhaoli Gao, Haiqing Gao, Baoying Li, Tao Peng, Bei Jiang, Xiangdong Yang, Zhao Hu
Diabetic nephropathy (DN) is one of the major causes of end‑stage renal failure. Grape seed proanthocyanidin extracts (GSPE) are known to act as antioxidants. The current study aimed to determine the effects of GSPE on the streptozotocin (STZ)‑induced diabetic rat model and to explore the underlying mechanism of its action. Wistar rats were induced into a diabetic state by injection of STZ and were treated with 250 mg·kg‑1·day‑1 GSPE for 24 weeks. Kidney samples were collected for observation of renal pathological changes by light microscope (periodic acid‑Schiff staining) and electron microscopy...
October 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29150663/publisher-correction-genome-wide-identification-and-expression-analyses-of-the-homeobox-transcription-factor-family-during-ovule-development-in-seedless-and-seeded-grapes
#3
Yunduan Li, Yanxun Zhu, Jin Yao, Songlin Zhang, Li Wang, Chunlei Guo, Steve van Nocker, Xiping Wang
 A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper.
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29141407/partial-solar-radiation-exclusion-with-color-shade-nets-reduce-the-degradation-of-organic-acids-and-flavonoids-of-grape-berry-vitis-vinifera-l
#4
Johan Martínez-Lüscher, Christopher Cody Lee Chen, Luca Brillante, Sahap Kaan Kurtural
The incidence of solar radiation on red-skinned grapes can promote the synthesis of flavonoid desirable for wine production, elevated temperature may impair their accumulation. We performed a shade cloth trial covering the fruit zone (from pepper-corn size to maturity) with four polyethylene 1-meter curtains with different optical properties (20% shading factor Pearl colored and 40% shading factor Aluminet, Blue and Black colored) and a Control with no cover. Cluster temperature was 3.7°C lower on the Southwest side in Black-40% clusters during the warmest part of the day compared to Control...
November 15, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29140987/dating-the-beginning-of-the-roman-viticultural-model-in-the-western-mediterranean-the-case-study-of-chianti-central-italy
#5
Riccardo Aversano, Boris Basile, Mauro Paolo Buonincontri, Francesca Carucci, Domenico Carputo, Luigi Frusciante, Gaetano Di Pasquale
Although domestication of the grapevine (Vitis vinifera L.) has been extensively documented, the history of genotype selection and evolution of vineyard management remain relatively neglected fields of study. The find of 454 waterlogged grapevine pips from a well-dated Etrusco-Roman site in the Chianti district (Tuscany, Central Italy) is an extraordinary chance to gain insights into the progress of viticulture occurring in a key historical period in one of the world's most famous wine regions. The molecular and geometrical analyses of grape seeds showed (a) the presence in the site of different grapevine individuals and (b) a sudden increase in pip size, occurring at around 200 BC, whic explainable by the selection and introduction of new varieties...
2017: PloS One
https://www.readbyqxmd.com/read/29140290/ameliorative-effects-of-grape-seed-proanthocyanidin-extract-on-growth-performance-immune-function-antioxidant-capacity-biochemical-constituents-liver-histopathology-and-aflatoxin-residues-in-broilers-exposed-to-aflatoxin-b%C3%A2
#6
Shahid Ali Rajput, Lvhui Sun, Niya Zhang, Mahmoud Mohamed Khalil, Xin Gao, Zhao Ling, Luoyi Zhu, Farhan Anwar Khan, Jiacai Zhang, Desheng Qi
Aflatoxicosis is a grave threat to the poultry industry. Dietary supplementation with antioxidants showed a great potential in enhancing the immune system; hence, protecting animals against aflatoxin B₁-induced toxicity. Grape seed proanthocyanidin extract (GSPE) one of the most well-known and powerful antioxidants. Therefore, the purpose of this research was to investigate the effectiveness of GSPE in the detoxification of AFB₁ in broilers. A total of 300 one-day-old Cobb chicks were randomly allocated into five treatments of six replicates (10 birds per replicate), fed ad libitum for four weeks with the following dietary treatments: 1...
November 15, 2017: Toxins
https://www.readbyqxmd.com/read/29138814/grape-seed-proanthocyanidin-extract-attenuates-varicocele%C3%A2-induced-testicular-oxidative-injury-in-rats-by-activating-the-nrf2%C3%A2-antioxidant-system
#7
Yong Wang, Fan Chen, Ming Liang, Shouzhen Chen, Yaofeng Zhu, Zhichuan Zou, Benkang Shi
The present study investigated whether grape seed proanthocyanidin extract (GSPE) can attenuate varicocele‑induced testicular oxidative injury through the nuclear factor (erythroid‑derived 2)‑like 2 (Nrf2) antioxidant pathway. A varicocele model in rats was established by partial ligation of the left renal vein. Following 4 weeks of GSPE administration, the decreased sperm count and motility and other pathological changes caused by varicocele were significantly alleviated, as indicated by the results of computer‑assisted sperm analysis and hematoxylin and eosin staining...
November 10, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29128226/camel-milk-protein-hydrolysates-with-improved-technofunctional-properties-and-enhanced-antioxidant-potential-in-in-vitro-and-in-food-model-systems
#8
Kholoud Awad Al-Shamsi, Priti Mudgil, Hassan Mohamed Hassan, Sajid Maqsood
Camel milk protein hydrolysates (CMPH) were generated using proteolytic enzymes, such as alcalase, bromelain, and papain, to explore the effect on the technofunctional properties and antioxidant potential under in vitro and in real food model systems. Characterization of the CMPH via degree of hydrolysis, sodium dodecyl sulfate-PAGE, and HPLC revealed that different proteins in camel milk underwent degradation at different degrees after enzymatic hydrolysis using 3 different enzymes for 2, 4, and 6 h, with papain displaying the highest degradation...
November 8, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29113217/grape-seed-proanthocyanidins-induce-mitochondrial-pathway-mediated-apoptosis-in-human-colorectal-carcinoma-cells
#9
Chen Zhang, Weili Chen, Xuhao Zhang, Yanbing Zheng, Fengli Yu, Yulong Liu, Yi Wang
Grape seed proanthocyanidins (GSPs) have been reported to possess a wide array of pharmacological and biochemical properties. Recently, GSPs have been reported to inhibit various types of colorectal cancer; however, the mechanism(s) involved remain unclear. The present study investigated the effects of GSPs on HCT-116 human colorectal carcinoma cell line. Exposure of these cells to GSPs for 48 h resulted in a significant concentration-dependent inhibition of cell viability. Further investigation indicated that GSPs induced apoptosis of these cells...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29078146/detailed-phenolic-composition-of-vidal-grape-pomace-by-ultrahigh-performance-liquid-chromatography-tandem-mass-spectrometry
#10
Lanxin Luo, Yan Cui, Shuting Zhang, Lingxi Li, Hao Suo, Baoshan Sun
Vidal Blanc grape (Vitis vinifera cv.) is the predominant white grape variety used for the production of icewine in China's Liaoning province. In this paper, the development and validation of the method by ultrahigh-performance liquid chromatography-tandem mass spectrometry has been performed for determination of the detailed phenolic composition in the skin, seed and stem of Vidal grapes. The validation of the method was realized by calculating the linearity, repeatability, precision, stability and the limits of detection (LOD) and quantification (LOQ) of standard solutions...
October 16, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29051443/vitis-vinifera-extract-ameliorate-hepatic-and-renal-dysfunction-induced-by-dexamethasone-in-albino-rats
#11
Nabil A Hasona, Ahmed A Alrashidi, Thamer Z Aldugieman, Ali M Alshdokhi, Mohammed Q Ahmed
This study was conducted to evaluate the biochemical effects of grape seed extract against dexamethasone-induced hepatic and renal dysfunction in a female albino rat. Twenty-eight adult female rats were divided randomly into four equal groups: Group 1: animals were injected subcutaneously with saline and consider as normal control one. Group 2: animals were injected subcutaneously with dexamethasone in a dose of 0.1 mg/kg body weight. Group 3: animals were injected subcutaneously with 0.1 mg/kg body weight of dexamethasone, and then treated with a grape seed extract in a dose of 200 mg/kg body weight by oral gavage...
April 11, 2017: Toxics
https://www.readbyqxmd.com/read/29039545/grape-seed-proanthocyanidins-protect-cardiomyocytes-against-hypoxia-reoxygenation-injury-by-attenuating-endoplasmic-reticulum-stress-through-perk-eif2%C3%AE-pathway
#12
Xin Wang, Dalin Jia, Juncheng Zhang, Wei Wang
The aim of the present study was to observe the protective effect of grape seed proanthocyanidins (GSPs) against endoplasmic reticulum (ER) stress‑mediated apoptosis caused by hypoxia/reoxygenation (H/R) injury in H9C2 cardiomyocytes along with its potential mechanisms. H9C2 cardiomyocytes underwent hypoxia for 3 h followed by reoxygenation for 3 h. Different doses of GSPs (50, 100 and 200 µg/ml) were administered 30 min before hypoxia. Cell viability was assessed, as well as lactic dehydrogenase (LDH) activity, cell apoptosis rate, expression levels of glucose‑regulated protein 78 (GRP78), C/EBP‑homologous protein (CHOP), protein kinase RNA‑like ER kinase (PERK), and eukaryotic translation initiation factor‑2 (eIF2α) mRNA and protein...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29039443/grape-seed-proanthocyanidins-inhibit-the-proliferation-migration-and-invasion-of-tongue-squamous-cell-carcinoma-cells-through-suppressing-the-protein-kinase%C3%A2-b-nuclear-factor-%C3%AE%C2%BAb-signaling-pathway
#13
Ninggang Yang, Jing Gao, Xin Cheng, Cuilan Hou, Yaya Yang, Yanxin Qiu, Mengrou Xu, Yuan Zhang, Shuangsheng Huang
Tongue squamous cell carcinoma (TSCC) is the most common oral squamous cell carcinoma. Despite significant advances in combined therapies, the 5-year survival rate of patients with TSCC has not notably improved; this is due to regional recurrences and lymph node metastasis. Grape seed proanthocyanidins (GSPs) are consumed as dietary supplements worldwide and possess anticancer activity against several different types of cancer. However, their effect on TSCC and the underlying mechanisms by which they function remain unclear...
September 28, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29037742/augmentation-of-chemical-and-organoleptic-properties-in-syzygium-cumini-wine-by-incorporation-of-grape-seeds-during-vinification
#14
K S VenuGopal, Chris Cherita, K A Anu-Appaiah
The role of grape seed tannins on improving organoleptic properties and its involvement in color stabilization in red wine are well established. The addition of grape seeds as the source of condensed tannins in fruit wine may provide a solution for its color instability and improvement of sensory attributes. Syzgium cumini is traditionally known for its therapeutic properties. In the current study, the influence of yeasts and grape seed addition during fermentation on the chromatic, phenolic and sensory attributes of the wine was accessed...
March 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29037689/intra-regional-classification-of-grape-seeds-produced-in-mendoza-province-argentina-by-multi-elemental-analysis-and-chemometrics-tools
#15
Brenda V Canizo, Leticia B Escudero, María B Pérez, Roberto G Pellerano, Rodolfo G Wuilloud
The feasibility of the application of chemometric techniques associated with multi-element analysis for the classification of grape seeds according to their provenance vineyard soil was investigated. Grape seed samples from different localities of Mendoza province (Argentina) were evaluated. Inductively coupled plasma mass spectrometry (ICP-MS) was used for the determination of twenty-nine elements (Ag, As, Ce, Co, Cs, Cu, Eu, Fe, Ga, Gd, La, Lu, Mn, Mo, Nb, Nd, Ni, Pr, Rb, Sm, Te, Ti, Tl, Tm, U, V, Y, Zn and Zr)...
March 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29027276/natural-medicines-for-acute-renal-failure-a-review
#16
REVIEW
Motahareh Boozari, Hossein Hosseinzadeh
Acute renal failure (ARF) is a life-threating disease with high mortality percentage. Two important mechanisms of ARF are inflammation and oxidative stress. Plants are rich source of antioxidant compounds and have a strong anti-inflammatory activity, so they may be useful for the treatment of ARF. Some herbal medicines are effective against different models of experimentally induced ARF such as cisplatin, gentamicin, glycerol, and ischemia-reperfusion injury. Some of these plants such as ginseng, black seed, ginger, garlic, grape, pomegranate, saffron, and green tea are so famous and are effective against various models of ARF...
October 13, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28993969/grape-seed-proanthocyanidin-and-swimming-exercise-protects-against-cognitive-decline-a-study-on-m1-acetylcholine-receptors-in-aging-male-rat-brain
#17
Satpati Abhijit, Muthangi V V Subramanyam, Sambe Asha Devi
Decline in cognition is one of the earliest signs of normal brain aging. Several dietary and non-pharmacological approaches have been tested to slow down this process. The aim of the present study was to assess the influence of grape seed proanthocyanidin extract (GSPE) either individually or in combination with swimming training on acetylcholine esterase activity (AChE) and m1 acetylcholine receptor (m1AChR) on the extent of cognitive decline with aging. The experimental protocol included the oral administration of GSPE (400 mg/kg body weight) for 14 weeks to 4 (adult) and 18-month-old (middle-aged) male Wistar rats along with swimming training...
December 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28987724/effect-of-proanthocyanidin-enriched-extracts-on-the-inhibition-of-wear-and-degradation-of-dentin-demineralized-organic-matrix
#18
Ana Paula Boteon, Melissa Thiemi Kato, Marília Afonso Rabelo Buzalaf, Anuradha Prakki, Linda Wang, Daniela Rios, Heitor Marques Honório
OBJECTIVES: The aim of this study was to evaluate the effect of Cranberry and Grape seed-enriched extract gels in inhibiting wear and degradation of demineralized organic matrix (DOM). DESIGN: 225 dentin specimens obtained from bovine incisors were randomly allocated into 5 groups (n=45): 10% Grape seed extract gel (GSE), 10% Cranberry extract gel (CE), 0.012% Chlorhexidine gel (CX), 1.23% NaF gel (F), and no active compound gel (P, placebo). Before the treatments, samples were demineralized by immersion in 0...
September 25, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28983752/cytotoxicity-and-apoptotic-cell-death-induced-by-vitis-vinifera-peel-and-seed-extracts-in-a431-skin-cancer-cells
#19
J Grace Nirmala, S Evangeline Celsia, Akila Swaminathan, R T Narendhirakannan, Suvro Chatterjee
Vitis vinifera. L is one of the most widely consumed fruits in the world and are rich in antioxidant abundant polyphenols. The present study was carried out to assess the antiproliferative and apoptotic effects of Vitis vinifera peel and seed extracts in an in vitro model using human epidermoid carcinoma A431 cell lines. Vitis vinifera peel and seed extracts were incubated with A431 cells to evaluate the antiproliferative, apoptotic effects and the morphological apoptotic changes induced by the extracts. Mitochondrial membrane potential was also measured after incubating the cells with extracts...
October 5, 2017: Cytotechnology
https://www.readbyqxmd.com/read/28974806/functional-crackers-incorporation-of-the-dietary-fibers-extracted-from-citrus-seeds
#20
Emin Yilmaz, Elif Karaman
Dietary fibers extracted from defatted press meals of orange and grapefruit seeds were used in the production of crackers and the crackers were evaluated for physicochemical, textural, sensory properties, and bioactive compounds. The unexplored fibers (grapes seeds and orange seeds) and wheat fiber were added at 2.9% levels. The effects of incorporation of different fibers on composition and consumer acceptability were evaluated. The textural stability during storage was also monitored. Although there were no significant differences for proximate compositions; fiber contents, antioxidant capacities, and phenolics compositions were significantly higher in the crackers containing orange seeds fiber...
September 2017: Journal of Food Science and Technology
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