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https://www.readbyqxmd.com/read/28076832/dietary-supplementation-of-grape-seed-and-skin-flour-mitigates-brain-oxidative-damage-induced-by-a-high-fat-diet-in-rat-gender-dependency
#1
Kamel Charradi, Mohamed Mahmoudi, Takwa Bedhiafi, Safwen Kadri, Salem Elkahoui, Ferid Limam, Ezzedine Aouani
It is unknown whether gender has an impact on brain injury in obesity, and, if so, whether treatment with grape seed and skin flour could exert a protective effect. Both male and female rats were fed a standard diet (SD) or a high fat diet (HFD) during eight weeks and treated with high dosage grape seed and skin flour (GSSF). Fat-induced oxidative stress was evaluated into the brain with a special emphasis on transition metals determination. HFD induced male-cholesterol overload (+78.12%) and an oxidative stress status characterized by increased lipoperoxidation (+68...
January 8, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28074795/comparative-effect-of-grape-seed-extract-vitis-vinifera-and-ascorbic-acid-in-oxidative-stress-induced-by-on-pump-coronary-artery-bypass-surgery
#2
Naser Safaei, Hossein Babaei, Rasoul Azarfarin, Ahmad-Reza Jodati, Alireza Yaghoubi, Mohammad-Ali Sheikhalizadeh
BACKGROUND: This study aimed to test the beneficial effect of grape seed extract (GSE) (Vitis vinifera) and Vitamin C in oxidative stress and reperfusion injury induced by cardiopulmonary bypass (CPB) in coronary artery bypass surgery. PATIENTS AND METHODS: In this randomized trial, 87 patients undergoing elective and isolated coronary bypass surgery included. The patients were randomly assigned into three groups (n = 29 each): (1) Control group with no treatment, (2) GSE group who received the extract 24 h before operation, 100 mg every 6 h, orally, (3) Vitamin C group who received 25 mg/kg Vitamin C through CPB during surgery...
January 2017: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/28031711/synergistic-anti-glioma-effect-of-a-coloaded-nano-drug-delivery-system
#3
Huae Xu, Feng Jia, Pankaj Kumar Singh, Shu Ruan, Hao Zhang, Xiaolin Li
The anti-glioma effect of temozolomide (Tem) is sometimes undermined by the emerging resistance. Recently, resveratrol (Res), herbal medicine extracted from grape seeds, has been demonstrated for its potential use in chemosensitization. In the current study, both these drugs were loaded simultaneously into nanoparticles with methoxy poly(ethylene glycol)-poly epsilon caprolactone (mPEG-PCL) as drug carriers in order to achieve better antitumor efficiency. Tem/Res-coloaded mPEG-PCL nanoparticles were constructed, characterized, and tested for antitumor effect on glioma cells by using in vitro and xenograft model system...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28027472/assessment-of-major-and-trace-element-bioavailability-in-vineyard-soil-applying-different-single-extraction-procedures-and-pseudo-total-digestion
#4
Tijana Milićević, Dubravka Relić, Sandra Škrivanj, Živoslav Tešić, Aleksandar Popović
A different single extraction procedures (CH3COOH, Na2EDTA, CaCl2, NH4NO3, deionized water), and pseudo-total digestion (aqua regia) were applied to determine major (Al, Fe, K, Mn, Na, P, S, and Si) and trace (Cd, Co, Cr, Cu, Mo, Ni, Pb, V, and Zn) element bioavailability in a topsoil from the experimental vineyard ("Radmilovac", Belgrade, Serbia). For the first time, the extraction with deionized water during 16 h was tested as an alternative method for isolating bioavailable major and trace elements from the soil...
December 19, 2016: Chemosphere
https://www.readbyqxmd.com/read/28011376/grape-seed-procyanidin-b2-inhibits-adipogenesis-of-3t3-l1-cells-by-targeting-peroxisome-proliferator-activated-receptor-%C3%AE-with-mir-483-5p-involved-mechanism
#5
Jun Zhang, Yazeng Huang, Haiyu Shao, Qing Bi, Jinping Chen, Zhaoming Ye
Procyanidins have lipolysis effect on adipose metabolism, but the underlying mechanism is not fully understood. The aim of present study was to examine the effect of grape seed procyanidin B2 (GSP) on the adipogenic differentiation of 3T3-L1 preadipocyte cell line and investigate the underlying mechanism. The results showed that GSP treatment significantly reduced the intracellular lipid accumulation in induced 3T3-L1 cells by targeting miR-483-5p as well as peroxisome proliferator-activated receptor γ (PPARγ)...
December 20, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27990170/evaluation-of-wound-healing-properties-of-grape-seed-sesame-and-fenugreek-oils
#6
Dorsaf Moalla Rekik, Sameh Ben Khedir, Kamilia Ksouda Moalla, Naziha Grati Kammoun, Tarek Rebai, Zouheir Sahnoun
Background. Medicinal plants have proved at all times to be a powerful remedy for health care. Accordingly, grape seed, sesame, and fenugreek extracted oils with pharmacological properties are investigated as wound treatments. This study assesses the potential of our oils for healing wounds induced on rats. Methods. Phytochemical analyses of oils have involved: quality value, polyphenol, chlorophylls, carotene, and fatty acids. Antibacterial activity was carried out. Antioxidant activity was evaluated: the scavenging effect on DPPH radicals, the reducing power, and β-carotene discoloration...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27987185/cloning-characterization-and-expression-analysis-of-a-gene-encoding-a-putative-lysophosphatidic-acid-acyltransferase-from-seeds-of-paeonia-rockii
#7
Qing-Yu Zhang, Li-Xin Niu, Rui Yu, Xiao-Xiao Zhang, Zhang-Zhen Bai, Ke Duan, Qing-Hua Gao, Yan-Long Zhang
Tree peony (Paeonia section Moutan DC.) is an excellent woody oil crop, and the cloning and functional analysis of genes related to fatty acid (FA) metabolism from this organism has not been reported. Lysophosphatidic acid acyltransferase (LPAAT), which converts lysophosphatidic acid (LPA) to phosphatidic acid (PA), catalyzes the addition of fatty acyl moieties to the sn-2 position of the LPA glycerol backbone in triacylglycerol (TAG) biosynthesis. This project reports a putative lysophosphatidic acid acyltransferase gene PrLPAAT1 isolated from Paeonia rockii...
December 16, 2016: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/27984208/oral-administration-of-grape-seed-polyphenol-extract-restores-memory-deficits-in-chronic-cerebral-hypoperfusion-rats
#8
Chen Chen, Yake Zheng, Tianwen Wu, Chuanjie Wu, Xuan Cheng
Chronic cerebral hypoperfusion (CCH) has been recognized as an important cause of both vascular dementia and Alzheimer's disease (AD), the two most prominent neurodegenerative diseases causing memory impairment in the elderly. However, an effective therapy for CCH-induced memory impairment has not yet been established. Grape seed polyphenol extract (GSPE) has powerful antioxidant properties and protects neurons and glia during ischemic injury, but its potential use in the prevention of CCH-induced memory impairment has not yet been investigated...
December 14, 2016: Behavioural Pharmacology
https://www.readbyqxmd.com/read/27979147/evaluation-of-the-influence-of-white-grape-seed-extracts-as-copigment-sources-on-the-anthocyanin-extraction-from-grape-skins-previously-classified-by-near-infrared-hyperspectral-tools
#9
Julio Nogales-Bueno, Berta Baca-Bocanegra, María José Jara-Palacios, José Miguel Hernández-Hierro, Francisco José Heredia
Hyperspectral imaging has been used to classify red grapes (Vitis vinifera L.) according to their predicted extractable total anthocyanin content (i.e. extractable total anthocyanin content determined by a hyperspectral method). Low, medium and high levels of predicted extractable total anthocyanin content were established. Then, grape skins were split into three parts and each part was macerated into a different model wine solution for a three-day period. Wine model solutions were made up with different concentration of copigments coming from white grape seeds...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27976407/potassium-uptake-and-redistribution-in-cabernet-sauvignon-and-syrah-grape-tissues-and-its-relationships-with-grape-quality-parameters
#10
María Concepción Ramos, María Paz Romero
BACKGROUND: This study investigated the potassium (K) levels in petiole and other grape tissues during ripening in Vitis vinifera Shiraz and Cabernet Sauvignon, grown in areas with differences in vigour, and with and without leaf thinning. K in petiole, seeds, skin and flesh were related to grape pH, acidity, berry weight and total soluble solids. RESULTS: Differences in K levels in petiole were in accordance with the differences in soil K. Leaf thinning gave rise to higher K levels in petiole but in grape tissues the differences were not significant in all samplings with greater differences at the end of the growing cycle...
December 15, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27976027/grape-seed-derived-antioxidant-beneficially-modulates-ageing-related-cellular-inflammatory-processes
#11
K S Petersen, V López, G Cásedas, C Smith
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27933323/assessing-collagen-and-micro-permeability-at-the-proanthocyanidin-treated-resin-dentin-interface
#12
Berdan Aydin, Lina Saleh Hassan, Grace Viana, Ana K Bedran-Russo
PURPOSE: To establish a fluorescence-based method to simultaneously assess micro-permeability and collagen cross-linking induced by chemical agents at the resin-dentin interface. MATERIALS AND METHODS: Three chemical agents were investigated (proanthocyanidin-rich grape seed extract: GSE; carbodiimide hydrochloride/N-hydroxysuccinimide: EDC/NHS; glutaraldehyde: GD) along with a control (distilled water) as primers applied on flat occlusal dentin surfaces of 48 teeth and restored with two commercially available etch-and-rinse adhesives...
December 8, 2016: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/27927886/biostability-of-the-proanthocyanidins-dentin-complex-and-adhesion-studies
#13
A A Leme-Kraus, B Aydin, C M P Vidal, R M Phansalkar, J W Nam, J McAlpine, G F Pauli, S Chen, A K Bedran-Russo
Oligomeric proanthocyanidins (OPACs) are potent and renewable natural bioactives possible to be refined into chemically standardized mixtures for biological applications. Herein, we found that multiscale interactions of OPACs with the dentin matrix create tight biointerfaces with hydrophobic methacrylate adhesives on wet surfaces. An enriched mixture of OPACs, with a known phytochemical profile, was produced from grape seed crude extract (Vitis vinifera; enriched grape seed extract [e-GSE]) and applied to dentin matrices to determine changes to the mechanical properties and biodegradability of the dentin matrix and favorable resin adhesion mechanisms...
December 7, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27902788/fertilization-of-grapevine-based-on-gene-expression
#14
Cheng Zhang, Haifeng Jia, Jingjue Zeng, Tariq Perraiz, Zhenqiang Xie, Xudong Zhu, Chen Wang
The application of genetic information in agricultural production is an important issue, which is highly worthy of attention. Gene expression data can accurately reflect the growth and metabolic status of plants, with which we can predict and monitor the nutritional requirements of plants and then derive accurate fertilization strategies. In this study, to verify the feasibility and workability of gene information-based fertilization strategies and to figure out the specific nutritional requirements of grapevine ( L...
November 2016: Plant Genome
https://www.readbyqxmd.com/read/27892838/effect-of-bioactive-primers-on-bacterial-induced-secondary-caries-at-the-tooth-resin-interface
#15
G E Kim, A A Leme-Kraus, R Phansalkar, G Viana, C Wu, S-N Chen, G F Pauli, Akb Bedran-Russo
Secondary caries at the tooth-resin interface is the primary reason for replacement of resin composite restorations. The tooth-resin interface is formed by the interlocking of resin material with hydroxyapatite crystals in enamel and collagen mesh structure in dentin. Efforts to strengthen the tooth-resin interface have identified chemical agents with dentin collagen cross-linking potential and antimicrobial activities. The purpose of the present study was to assess protective effects of bioactive primer against secondary caries development around enamel and dentin margins of class V restorations, using an in vitro bacterial caries model...
November 28, 2016: Operative Dentistry
https://www.readbyqxmd.com/read/27891467/an-in-vitro-comparative-study-of-shear-bond-strength-of-composite-resin-to-bleached-enamel-using-three-herbal-antioxidants
#16
Pratap Kumar Mukka, Nanda Kumar Komineni, Sambashivarao Pola, E Soujanya, Anand Ramtheerth Karne, Bhasker Nenavath, Sandeep Shiva, Pallavi Vuppunuthula
INTRODUCTION: If adhesive restorations are carried out imme-diately, the Shear Bond Strength (SBS) to bleached enamel is reduced. The use of antioxidants can be highlighted since it seems to be a more effective alternative to reduce or remove the residual oxygen and immediate improvement in SBS. AIM: The purpose of this in-vitro study was an attempt to regain the lost bond strength, for which, the comparison of SBS of composite resin to bleached enamel was carried out using various antioxidants i...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27889390/safety-assessment-of-4-week-oral-intake-of-proanthocyanidin-rich-grape-seed-extract-in-healthy-subjects
#17
Atsushi Sano
A clinical study was conducted to assess the safety and tolerability of oral doses of proanthocyanidin-rich grape seed extract (GSE) in healthy Japanese adult volunteers. In an open-label, 4-week toxicity test, 29 subjects daily received 1000, 1500, or 2500 mg GSE orally. Serum Fe levels of two subjects in the 2500 mg GSE group decreased to 61 and 60 μg/100 mL from 205 and 182 μg/100 mL at baseline respectively, at second week of GSE consumption; these values are low but within the normal range for the Japanese population...
November 24, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27887737/polyphenolic-diversity-and-characterization-in-the-red-purple-berries-of-east-asian-wild-vitis-species
#18
Kazuya Koyama, Hiroshi Kamigakiuchi, Kazuhiro Iwashita, Ryosuke Mochioka, Nami Goto-Yamamoto
Grapes (Vitis spp.) produce diverse polyphenolic compounds, which are phytochemicals that contribute to human health. In this study, the polyphenolic profiles of the red-purple berries of two wild grape species native to Japan, Vitis ficifolia and V. coignetiae, and their interspecific hybrid cultivars were investigated and compared with the profiles of V. vinifera and V. × labruscana cultivars. Proanthocyanidins (PAs) were present at lower concentrations in both skins and seeds of wild grape species and their hybrid cultivars than those in V...
February 2017: Phytochemistry
https://www.readbyqxmd.com/read/27886147/emerging-phytochemicals-for-the-prevention-and-treatment-of-head-and-neck-cancer
#19
REVIEW
Santosh K Katiyar
Despite the development of more advanced medical therapies, cancer management remains a problem. Head and neck squamous cell carcinoma (HNSCC) is a particularly challenging malignancy and requires more effective treatment strategies and a reduction in the debilitating morbidities associated with the therapies. Phytochemicals have long been used in ancient systems of medicine, and non-toxic phytochemicals are being considered as new options for the effective management of cancer. Here, we discuss the growth inhibitory and anti-cell migratory actions of proanthocyanidins from grape seeds (GSPs), polyphenols in green tea and honokiol, derived from the Magnolia species...
November 24, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27882891/a-comparative-mass-spectrometric-study-of-fatty-acids-and-metals-in-some-seed-extracts
#20
Sonia Niculina Suvar, R Bleiziffer, P Podea, A Iordache, C Voica, R Zgavarogea, M Culea
A major cause of cardiovascular diseases and cancer is diet content, so the optimization of micronutrients in food is very important. Omega-3 fatty acids supplementation for patients had beneficial effects on subjective global assessment score and metabolic profiles. Fatty acids content and the metal ions in different seeds (e.g. linseed, poppy, grape, hemp, nuts, pumpkin, sesame, watermelon, chia) recommended as food supplements, purchased on the Romanian market, were compared. Gas chromatography coupled to mass spectrometry (GC-MS) was used as an excellent technique for fatty acids identification and quantitation, and inductively coupled plasma mass spectrometer (ICP-MS) for analytical measurements of metals...
2016: European Journal of Mass Spectrometry
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