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grape seed

Joan Serrano, Àngela Casanova-Martí, Mayte Blay, Ximena Terra, Anna Ardévol, Montserrat Pinent
Food intake depends on homeostatic and non-homeostatic factors. In order to use grape seed proanthocyanidins (GSPE) as food intake limiting agents, it is important to define the key characteristics of their bioactivity within this complex function. We treated rats with acute and chronic treatments of GSPE at different doses to identify the importance of eating patterns and GSPE dose and the mechanistic aspects of GSPE. GSPE-induced food intake inhibition must be reproduced under non-stressful conditions and with a stable and synchronized feeding pattern...
October 20, 2016: Nutrients
Nasser Razmaraii, Hossein Babaei, Alireza Mohajjel Nayebi, Gholamreza Assadnassab, Javad Ashrafi Helan, Yadollah Azarmi
Purpose: The aim of the present study was to determine the ability of grape seed extract (GSE) as a powerful antioxidant in preventing adverse effect of doxorubicin (DOX) on heart function. Methods: Male rats were divided into three groups: control, DOX (2 mg/kg/48h, for 12 days) and GSE (100 mg/kg/24h, for 16 days) plus DOX. Left ventricular (LV) function and hemodynamic parameters were assessed using echocardiography, electrocardiography and a Millar pressure catheter. Histopathological analysis and in vitro antitumor activity were also evaluated...
September 2016: Advanced Pharmaceutical Bulletin
Xin Wen, Minghui Zhu, Rui Hu, Jinhong Zhao, Ziye Chen, Jingming Li, Yuanying Ni
To explore the potential of the large amount of grape pomace in wineries of China, oils of three Eurasian grape cultivars (Chardonnay, Merlot and Carbernet Sauvignon) and two Chinese traditional grape cultivars (Vitis amurensis and Vitis davidii), were characterised. The results showed seed oil properties differ for various grape varities. Grape seed oils were demonstrated to be good sources of polyunsaturated fatty acid (PUFA) (63.88-77.12 %), sterols (227.99-338.83 mg/100 g oil) and tocotrienols (320...
July 2016: Journal of Food Science and Technology
Shuting Zhang, Lingxi Li, Yan Cui, Lanxin Luo, Yuanyuan Li, Peiyu Zhou, Baoshan Sun
Separation of plant proanthocyanidins remains a major challenge for scientists due to the structural diversity and complexity. In this work, a new and effective method was developed for preparative separation of grape seed proanthocyanidins (GSPs) according to degree of polymerization (DP) by high-speed counter-current chromatography (HSCCC). Under the optimized HSCCC conditions, GSPs could be separated into seven distinct fractions (F1-F7) with mean degree of polymerization in increasing order, from 1.44 to 6...
March 15, 2017: Food Chemistry
Bice S Martincigh, Moses A Ollengo
The photostabilizing ability of grape seed extract on three common sunscreen absorbers: 2-ethylhexyl-p-methoxcinnamate (EHMC), benzophenone-3 (BP3) and tert-butylmethoxy dibenzoylmethane (BMDBM), was investigated. Samples were exposed to simulated solar radiation and monitored by spectrophotometric and chromatographic methods. The chemical composition of the grape seed extract was determined by GC-MS and HPLC-MS and the major secondary metabolites were found to be epicatechin and catechin. Exposure of the extract to UV radiation increased the UV absorption capacity of the extract...
October 19, 2016: Photochemistry and Photobiology
Roda Seseogullari-Dirihan, Mustafa Murat Mutluay, David H Pashley, Arzu Tezvergil-Mutluay
OBJECTIVE: Inactivation of dentin proteases by crosslinkers has been suggested as a way to prevent the degradation of dentin collagen in the hybrid layer. However, it is not known if the inhibition is reversible. The aim of this study was to evaluate the inactivation effect of various crosslinkers on dentin protease activity over a period of 6 months. METHODS: Demineralized dentin beams (1×2×6mm, n=10/group) were treated with (1) 1% glutaraldehyde (GA1), (2) 5% glutaraldehyde (GA5), (3) 1% grape seed extract (GS1), (4) 5% grape seed extract (GS5), (5) 10% sumac berry extract (S), (6) 20μM curcumin (CR20), and (7) 200μM curcumin (CR200) for 5min...
October 10, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
Meherzia Mokni, Mohamed Amri, Ferid Limam, Ezzedine Aouani
In the present study, we investigated the effect of grape seed and skin supplement (GSSS), on lactating dairy ewes' production. Ten dairy pregnant ewes from northern Tunisia were allocated to two groups: control diet (C) and supplemented with 20 % (w/w) GSSS. The experiment lasted for 8 weeks and took place after 2 months of lambing. During the experiment, daily milk yield and milk composition were determined. Supplementation of the diet with GSSS increased milk production (P < 0.001), calcium (P < 0...
October 15, 2016: Tropical Animal Health and Production
Giovanna Simonetti, Felicia Diodata D'Auria, Nadia Mulinacci, Marzia Innocenti, Donato Antonacci, Letizia Angiolella, Anna Rita Santamaria, Alessio Valletta, Livia Donati, Gabriella Pasqua
Several human skin diseases are associated with fungi as dermatophytes and Malassezia. Skin mycoses are increasing and new alternatives to conventional treatments with improved efficacy and/or safety profiles are desirable. For the first time, the anti-dermatophytes and the anti-Malassezia activities of Vitis vinifera seed extracts obtained from different table and wine cultivars have been evaluated. Geometric minimal inhibitory concentration ranged from 20 to 97 µg/mL for dermatophytes and from 32 to 161 µg/mL for Malassezia furfur...
October 13, 2016: Phytotherapy Research: PTR
Marlena K Sheridan, Ryan J Elias
Acetaldehyde is responsible for many of the beneficial changes that occur in red wine as a result of oxidation. Ethylidene bridges are formed between flavonoids upon their reaction with acetaldehyde, which can contribute to improvements in color stability and SO2-resistant pigments. In the present study, the reactions between acetaldehyde and various flavonoids (catechin, tannins from grape seed extract, and malvidin-3-glucoside) were examined in a model wine system. Lower pH conditions were seen to significantly increase the rate of reaction with acetaldehyde while dissolved oxygen did not affect the rate...
October 13, 2016: Journal of Agricultural and Food Chemistry
Eunice Molinar-Toribio, Elisabet Fuguet, Sara Ramos-Romero, Núria Taltavull, Lucía Méndez, M Rosa Nogués, Isabel Medina, Josep Lluís Torres, Jara Pérez-Jiménez
PURPOSE: Polyphenol metabolites are key mediators of the biological activities of polyphenols. This study aimed to evaluate the long-term effects of a high-fat high-sucrose (HFHS) diet on the metabolism of proanthocyanidins from grape seed extract (GSE). METHODS: Adult female Wistar-Kyoto rats were fed a standard (STD) or HFHS diet supplemented or not with GSE for 16 weeks. PA metabolites were determined by targeted HPLC-MS/MS analysis. RESULTS: A lower concentration of total microbial-derived PA metabolites was present in urine and the aqueous fraction of faeces in the HFHS + GSE group than in the STD + GSE group...
October 12, 2016: European Journal of Nutrition
Runze Yu, Michael G Cook, Ralph S Yacco, Aude Annie Watrelot, Gregory Gambetta, James A Kennedy, S Kaan Kurtural
The relationships between variations in grapevine (Vitis vinifera L. cv. Merlot) fruit zone light exposure and water deficits and the resulting berry flavonoid composition were investigated in a hot climate. The experimental design involved application of mechanical leaf removal (control, pre-bloom, post-fruit set) and differing water deficits (sustained deficit irrigation and regulated deficit irrigation). Flavonol and anthocyanin concentration was measured by C18 reversed-phased HPLC and increased with pre-bloom leaf removal in 2013, but with post-fruit set leaf removal in 2014...
October 12, 2016: Journal of Agricultural and Food Chemistry
Yi Zhou, Bao-Ying Li, Xiao-Li Li, Ya-Juan Wang, Zhen Zhang, Fei Pei, Quan-Zhen Wang, Jun Zhang, Ya-Wei Cai, Mei Cheng, Hai-Qing Gao
Grape seed procyanidin B2 (GSPB2) exerts a variety of potent protective pharmacological effects on diabetic complications. The renal protective effects of GSPB2 and the target protein mimecan regulated by GSPB2, discovered in a previous quantitative proteomic analysis, were assessed in mice with diabetic nephropathy Twenty-four db/db mice were divided into 2 groups of the vehicle-treated and GSPB2-treated (30 mg/kg/d) diabetic groups. All animals were observed for 10 weeks. Treatment with GSPB2 resulted in an improvement in body weight increase and serum levels of triglyceride, total cholesterol, advanced glycation end products, and urinary albumin excretion in comparison with the vehicle-treated diabetic mice (P < ...
September 2016: Iranian Journal of Kidney Diseases
Mingxing Tu, Xianhang Wang, Tongying Feng, Xiaomeng Sun, Yaqiong Wang, Li Huang, Min Gao, Yuejin Wang, Xiping Wang
Drought is one of the most serious factors that limit agricultural productivity and there is considerable interest in understanding the molecular bases of drought responses and their regulation. While numbers of basic leucine zipper (bZIP) transcription factors (TFs) are known to play key roles in response of plants to various abiotic stresses, only a few group K bZIP TFs have been functionally characterized in the context of stress signaling. In this study, we characterized the expression of the grape (Vitis vinifera) group K bZIP gene, VlbZIP36, and found evidence for its involvement in response to drought and the stress-associated phytohormone abscisic acid (ABA)...
November 2016: Plant Science: An International Journal of Experimental Plant Biology
A Klančnik, M Šikić Pogačar, K Trošt, M Tušek Žnidarič, B Mozetič Vodopivec, S Smole Možina
AIMS: To define anti-Campylobacter jejuni activity of an extract from waste skins and seeds of Pinot noir grapes (GSS) and of resveratrol, and possible resistance mechanisms, and the influence of these on C. jejuni morphology. METHODS AND RESULTS: Using gene-specific knock-out C. jejuni mutants and an efflux-pump inhibitor, we show CmeABC as the most active efflux pump for extrusion across the outer membrane of GSS extract and resveratrol. Using polystyrene and pig small-intestine epithelial (PSI) and human foetal small intestine (H4) cell lines, GSS extract shows efficient inhibition of adhesion of C...
October 6, 2016: Journal of Applied Microbiology
Thuy Nguyen, Meredith Kuchera, Katie Smoot, Charles Diako, Beata Vixie, Carolyn F Ross
The objective of this study was to determine if Chardonnay grape seed pomace (GSP), a waste stream of wine production, could be used as a functional ingredient in brewed coffee. Two consumer panels were conducted to assess the acceptance of coffee at coffee replacement (w/w) values of 0% (control), 6.25%, 12.50%, 18.75%, or 25% GSP. The 1st consumer panel (n = 80) assessed the coffee samples served "black." The 2nd panel (n = 67) assessed the coffee samples with adjustment (that is, sweeteners, milk, and cream) options available...
October 5, 2016: Journal of Food Science
Aynur Kurt, Hülya Torun, Nesrin Colak, Gerald Seiler, Sema Hayirlioglu-Ayaz, Faik Ahmet Ayaz
BACKGROUND: The hybrid grape cultivar Isabel (Vitis labrusca x V. vinifera) is widely grown in the Black Sea region of Turkey and constitutes an important part of the diet of its inhabitants. Phenological and ampelographical studies of the grape have previously been performed, but there are no data concerning nutrient composition. Its nutrient content needs to be investigated to ascertain its potential economic and nutritional uses in the region. RESULTS: The concentrations (range, g kg(-1) fresh weight) of major soluble sugars (fructose; 2...
October 3, 2016: Journal of the Science of Food and Agriculture
Gabriela N Mattos, Renata V Tonon, Angela A L Furtado, Lourdes M C Cabral
The wine industry is responsible for the production of million tons of waste, such as grape skin, stalk, sludge and seeds, which can be considered inexpensive phenolic compounds sources, due to incomplete extraction during wine production. Phenolic compounds, also called as polyphenols, are the most abundant bioactive compounds in grape composition and are recognized by their antioxidant and antimicrobial potential. Because of their functional properties, extracts obtained from grape wastes, which are rich in phenolic compounds, can be employed in development of many products ranging from medical to food applications, decreasing the growth of spoilage and pathogenic microorganisms and inhibiting lipid oxidation...
October 3, 2016: Journal of the Science of Food and Agriculture
Juan Zhan, Kun Wang, Conghui Zhang, Chunxiu Zhang, Yueqiang Li, Ying Zhang, Xiaoyan Chang, Qiaodan Zhou, Ying Yao, Yanyan Liu, Gang Xu
Grape seed proanthocyanindin extract (GSPE) is a polyphenolic bioflavonoid derived from grape seeds and has been widely studied for its potent antioxidant, anti-inflammatory and antitumor activities. HMGB1 is a newly discovered danger-associated molecular pattern (DAMP) that has potent proinflammatory effects once released by necrotic cells. However, the effect of GSPE on the HMGB1, and the relationship of those two with acute kidney injury and chronic kidney fibrosis are unknown. This study aimed to investigate the impact of GSPE on acute kidney injury and chronic fibrosis...
2016: International Journal of Molecular Sciences
M Ibars, A Ardid-Ruiz, M Suárez, B Muguerza, C Bladé, G Aragonès
OBJECTIVE: Dietary obesity is usually linked with hypothalamic leptin resistance, in which the primary impact is an interference in the homeostatic control of body weight and appetite. Notably, proanthocyanidins (PACs), which are the most abundant phenolic compounds present in human diet, modulate adiposity and food intake. The aim of this study was to assess whether PACs could re-establish appropriate leptin signalling in both the hypothalamus and peripheral tissues. DESIGN: Male Wistar rats were fed either a standard chow diet (STD group, n=7) or a cafeteria diet (CD) for 13 weeks...
October 18, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Jenny T Mao, Jane Smoake, Heesung Park, Qing-Yi Lu, Bingye Xue
Grape seed procyanidin extract (GSE) has been reported to exert antineoplastic properties via the inhibition of cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) eicosanoid pathways. In addition, ample data link carcinogenesis to inflammatory events involving other major eicosanoid metabolic pathways, including prostacyclin (PGI2) and 15-Hydroxyeicosatetraenoic acid (15-HETE). We therefore evaluated the effects of GSE on prostacyclin synthase (PTGIS)/PGI2 and 15-lipoxigenase-2 (15-LOX-2)/15-HETE productions by human lung premalignant and malignant cells and correlated the findings with anti-proliferative or pro-apoptotic effects of GSE...
September 22, 2016: Cancer Prevention Research
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