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https://www.readbyqxmd.com/read/29785236/the-efficacy-of-a-ceramide-based-cream-in-mild-to-moderate-atopic-dermatitis
#1
Zoe Diana Draelos, Isabelle Raymond
Objective: The goal of this study was to determine if a therapeutic cream containing PC-104 synthetic ceramides and other ingredients could help to ameliorate signs and symptoms of mild-to-moderate atopic dermatitis and other xerotic or pruritic dermatoses. Design: In this single-site, four-week study, subjects (n=50) were instructed to apply the study product three times daily to all affected areas, including a target site for evaluation and photography at baseline, Week 2, and Week 4 visits. Setting: This study took place in the private practice of the senior author...
May 2018: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29768882/grape-seed-extract-alone-or-combined-with-atropine-in-treatment-of-malathion-induced-neuro-and-genotoxicity
#2
Omar M E Abdel-Salam, Asmaa F Galal, Mahrousa M Hassanane, Lamiaa M Salem, Somaia A Nada, Fatma A Morsy
The aim of this study was to investigate the effect of treatment with grape seed extract (GSE) on the neurotoxic and genotoxic effects of acute malathion exposure. Rats received malathion (150 mg/kg by i.p. injection) for two successive days alone or combined with GSE at doses of 150 or 300 mg/kg, orally or with GSE at 300 mg/kg and atropine at a dose of 2 mg/kg, i.p. Malondialdehyde (MDA), reduced glutathione (GSH), nitric oxide, paraoxonase (PON1) were determined in cortex, striatum, and rest of brain tissue (subcortex)...
January 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29747667/protective-effect-of-grape-seed-and-skin-extract-against-high-fat-diet-induced-dyshomeostasis-of-energetic-metabolism-in-rat-lung
#3
Mohamed El Ayed, Safwen Kadri, Maha Mabrouk, Ezzedine Aouani, Salem Elkahoui
BACKGROUND: Obesity is currently one of the major epidemics of this millennium and affects poeples throughout the world. It causes multiple systemic complications as it significantly interferes with respiratory function. OBJECTIVE: We aimed in the present work to study the effect of high fat diet (HFD) on lung oxidative stress and energy metabolism alterations, as well as the putative protection afforded by grape seed and skin extract (GSSE). METHODS: We started by characterizing the GSSE and its composition using gas chromatography coupled to mass spectrometry (GC-MS)...
May 10, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29743442/fluoride-induced-iron-overload-contributes-to-hepatic-oxidative-damage-in-mouse-and-the-protective-role-of-grape-seed-proanthocyanidin-extract
#4
Qiang Niu, Ping He, Shangzhi Xu, Ruling Ma, Yusong Ding, Lati Mu, Shugang Li
Emerging evidence has demonstrated that iron overload plays an important role in oxidative stress in the liver. This study aimed to explore whether fluoride-induced hepatic oxidative stress is associated with iron overload and whether grape seed proanthocyanidin extract (GSPE) alleviates oxidative stress by reducing iron overload. Forty Kunming male mice were randomly divided into 4 groups and treated for 5 weeks with distilled water (control), sodium fluoride (NaF) (100 mg/L), GSPE (400 mg/kg bw), or NaF (100 mg/L) + GSPE (400 mg/kg bw)...
2018: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/29740325/extract-enriched-in-flavan-3-ols-and-mainly-procyanidin-dimers-improves-metabolic-alterations-in-a-mouse-model-of-obesity-related-disorders-partially-via-estrogen-receptor-alpha
#5
Daniela Leonetti, Raffaella Soleti, Nicolas Clere, Luisa Vergori, Caroline Jacques, Lucie Duluc, Catherine Dourguia, Maria C Martínez, Ramaroson Andriantsitohaina
Red wine polyphenol extracts improve cardiovascular and metabolic disorders linked to obesity. Their vascular protection is mediated by the activation of the alpha isoform of the estrogen receptor (ERα). In the present study, we explored the effects of a grape seed extract (GSE) enriched in the flavan-3-ols procyanidin dimers on obesity-related cardiovascular and metabolic disorders; with a particular interest in the role/contribution of ERα. Ovariectomized wild type or ERα knockout (KO) mice were fed with standard or western diet, supplemented or not with GSE, for 12 weeks...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29725583/evaluation-of-the-systemic-toxicity-and-mutagenicity-of-oligopin%C3%A2-procyanidolic-oligomers-opc-extracted-from-french-maritime-pine-bark-extract
#6
L Segal, M G Penman, Y Piriou
The potential systemic toxicity of Oligopin®, a French Maritime Pine Bark extract (FMPBE) rich in procyanidolic oligomers, was evaluated in an acute oral limit test and a 90-day repeated dose oral toxicity study with Sprague Dawley rats. The potential mutagenicity was assessed in a bacterial reverse mutation assay and in vitro mammalian chromosome aberration assay with human lymphocytes. The results indicate that Oligopin® was nongenotoxic in both bacterial and human cell assays, was not acutely toxic via oral administration at up to 2000 mg/kg and was well tolerated following 90 days of oral administration to SD rats, with a no observed adverse effect level of 1000 mg/kg/day...
2018: Toxicology Reports
https://www.readbyqxmd.com/read/29720929/antioxidant-effects-of-compound-walnut-oil-capsule-in-mice-aging-model-induced-by-d-galactose
#7
Huandong Zhao, Jian Li, Juan Zhao, Yang Chen, Caiping Ren, Yuxiang Chen
Background: Many plant original foods have been shown beneficial effects in humans. In the previous work, we have developed a compound capsule which contains major constituents of walnut oil and grape seed extract. Objective: To investigate the antioxidant effects of the Compound Walnut Oil Capsule (WOC) in aging model induced by D-gal. Design: 70 C57BL/6J mice were randomly divided into seven groups. Mice in normal group received daily subcutaneous injection of saline while the control group, WOC groups, Vitamin C (VC) group and pure walnut oil group received daily subcutaneous injection of D-galactose (D-gal) for 8 weeks...
2018: Food & Nutrition Research
https://www.readbyqxmd.com/read/29719667/effects-of-chitosan-edible-coating-containing-grape-seed-extract-on-the-shelf-life-of-refrigerated-rainbow-trout-fillet
#8
Parviz Hassanzadeh, Mehran Moradi, Nasim Vaezi, Mir-Hassan Moosavy, Razzagh Mahmoudi
In recent years, use of edible coatings as carriers of food additives and antimicrobial compounds has been considered in fishery products. This study was carried out to evaluate the effects of 2.00% chitosan coating singly and combined with 0.10% grape seed extract (GSE) on microbial (mesophils and psychrophils counts), chemical (thiobarbituric acid; TBA), pH and peroxide value (PV) and sensorial properties of rainbow trout fillet stored at 4 ° C over a period of 15 days. The coating had a significant effect in reducing aerobic mesophilic and psychrophilic bacteria counts...
2018: Veterinary Research Forum
https://www.readbyqxmd.com/read/29701895/interactions-between-flavonoid-rich-extracts-and-sodium-caseinate-modulate-protein-functionality-and-flavonoid-bioaccessibility-in-model-food-systems
#9
Jennifer L Elegbede, Min Li, Owen G Jones, Osvaldo H Campanella, Mario G Ferruzzi
With growing interest in formulating new food products with added protein and flavonoid-rich ingredients for health benefits, direct interactions between these ingredient classes becomes critical in so much as they may impact protein functionality, product quality, and flavonoids bioavailability. In this study, sodium caseinate (SCN)-based model products (foams and emulsions) were formulated with grape seed extract (GSE, rich in galloylated flavonoids) and green tea extract (GTE, rich in nongalloylated flavonoids), respectively, to assess changes in functional properties of SCN and impacts on flavonoid bioaccessibility...
April 27, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29701782/grape-seed-procyanidin-extract-inhibits-adipogenesis-and-stimulates-lipolysis-of-porcine-adipocytes-in-vitro
#10
S Wei, Y Zheng, M Zhang, H Zheng, P Yan
The objective of this paper was to evaluate in vitro effect of grape seed procyanidin extract (GSPE) on differentiation, proliferation, and lipolysis of porcine adipocytes, providing a molecular basis for the use of GSPE in pig fat regulation. Primary preadipocytes isolated from subcutaneous adipose tissue of pigs were used as the in vitro cell model. Treatment of GSPE repressed preadipocyte differentiation, as evidenced by reduced lipid accumulation, decreased mRNA expressions of peroxisome proliferator-activated receptor gamma (PPARγ) and fatty acid binding protein 4 (FABP4) , as well as enhanced expressions of preadipocyte factor-1 (Pref-1)...
April 26, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29695830/development-of-a-3d-seed-morphological-tool-for-grapevine-variety-identification-and-its-comparison-with-ssr-analysis
#11
Avshalom Karasik, Oshrit Rahimi, Michal David, Ehud Weiss, Elyashiv Drori
Grapevine (Vitis vinifera L.) is one of the classical fruits of the Old World. Among the thousands of domesticated grapevine varieties and variable wild sylvestris populations, the range of variation in pip morphology is very wide. In this study we scanned representative samples of grape pip populations, in an attempt to probe the possibility of using the 3D tool for grape variety identification. The scanning was followed by mathematical and statistical analysis using innovative algorithms from the field of computer sciences...
April 25, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29690545/use-of-plant-and-herb-derived-medicine-for-therapeutic-usage-in-cardiology
#12
REVIEW
Ye Eun Koo, Jiwon Song, Soochan Bae
Cardiovascular diseases (CVDs) have become prominent in mortality and morbidity rates. Prevalent cardiovascular conditions, such as hypertension, atherosclerosis and oxidative stress, are increasing at an alarming rate. Conventional drugs have been associated with adverse effects, suggesting a need for an alternative measure to ameliorate CVD. A number of plant- and herb-derived preventative food and therapeutic drugs for cardiovascular conditions are progressively used for their various benefits. Naturally derived food and drugs have fewer side effects because they come from natural elements; preventative food, such as grape seed, inhibits changes of histopathology and biomarkers in vital organs whereas therapeutic drugs, for instance Xanthone, improve heart functions by suppressing oxidative stress of myocyte...
April 22, 2018: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29684110/mechanistic-insights-into-anticancer-properties-of-oligomeric-proanthocyanidins-from-grape-seeds-in-colorectal-cancer
#13
Preethi Ravindranathan, Divya Pasham, Uthra Balaji, Jacob Cardenas, Jinghua Gu, Shusuke Toden, Ajay Goel
Although the anticancer properties of oligomeric proanthocyanidins (OPCs) from grape seeds have been well recognized, the molecular mechanisms by which they exert anticancer effects are poorly understood. In this study, through comprehensive RNA-sequencing-based gene expression profiling in multiple colorectal cancer cell lines, we for the first time illuminate the genome-wide effects of OPCs from grape seeds in colorectal cancer. Our data revealed that OPCs affect several key cancer-associated genes. In particular, genes involved in cell cycle and DNA replication were most significantly and consistently altered by OPCs across multiple cell lines...
April 19, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29683391/grape-seed-extract-supplementation-attenuates-the-blood-pressure-response-to-exercise-in-prehypertensive-men
#14
Jong-Kyung Kim, Kyung-Ae Kim, Hyun-Min Choi, Seung-Kook Park, Charles L Stebbins
We tested the hypothesis that exaggerated pressor responses observed in prehypertensive males (N = 9) during dynamic exercise are attenuated following acute dietary supplementation with grape seed extract (GSE) (i.e., a single dose). Effects of placebo and GSE (300 mg) on systolic blood pressure, diastolic blood pressure, mean arterial pressure (MAP), cardiac output (CO), stroke volume (SV), total vascular conductance (TVC), and rate × pressure product (RPP) in response to two submaximal cycling workloads (40% and 60% VO2peak ) were compared 2 h after ingestion of GSE or placebo on different days, 1 week apart...
April 23, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29680058/first-evidence-of-epicatechin-vanillate-in-grape-seed-and-red-wine
#15
Wen Ma, Pierre Waffo-Téguo, Michäel Jourdes, Hua Li, Pierre-Louis Teissedre
Flavan-3-ols are units incorporating condensed tannin, which are widely present in grape and wine. They play a considerable role in wine sensory perception such as astringency, bitterness and mouth-feel. In grape and wine, the flavan-3-ols reported to date are (epi)catechin, (epi)gallocatechin, (epi)gallocatechin gallate and (epi)catechin glycoside. This study now shows the presence of a new flavan-3-ol epicatechin vanillate in grape seed and red wine. A putative unknown flavan-3-ol derived from grape seed was targeted by LC-HRMS/MS...
September 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29680036/utilization-of-a-freeze-thaw-treatment-to-enhance-phenolic-ripening-and-tannin-oxidation-of-grape-seeds-in-red-vitis-vinifera-l-cultivars
#16
Laura Rustioni, Gabriele Cola, Josh VanderWeide, Patrick Murad, Osvaldo Failla, Paolo Sabbatini
Phenolic ripening represents a major interest for quality wine producers. Nevertheless, climatic or genotypical limitations can often prevent optimal maturation process. During winemaking seeds can be easily separated and technologically processed to improve their quality. Relying on the key role of oxidation for phenolic ripening, a freeze-thaw treatment was proposed to improve the fruit quality for potential use in challenging growing conditions. The experiment was carried on in two distinctive viticultural areas, Michigan and Italy...
September 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29668036/optimization-of-extraction-of-hypoglycemic-ingredients-from-grape-seeds-and-evaluation-of-%C3%AE-glucosidase-and-%C3%AE-amylase-inhibitory-effects-in-vitro
#17
Fansheng Kong, Yaru Qin, Zhipeng Su, Zhengxiang Ning, Shujuan Yu
Grape seeds full with oil and also rich in hypoglycemic ingredients. This study is to improve the comprehensive utilization of grape seeds and the quality of grape seeds oil. Extract water soluble active substances before extracting oil from grape seeds, which show the grape seeds in water soluble extracts containing TP, TC, PC contents, respectively, are 171.1 ± 1.1, 658.8 ± 0.2, 482.3 ± 0.2 (mg GSAE/g). Also we found GSAE samples containing catechin and epicatechin were 44.12 ± 0.21 mg/mL, 111.23 ± 1...
April 18, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29664082/unsaponifiable-fraction-isolated-from-grape-vitis-vinifera-l-seed-oil-attenuates-oxidative-and-inflammatory-responses-in-human-primary-monocytes
#18
Maria C Millan-Linares, Beatriz Bermudez, Maria E Martin, Ernesto Muñoz, Rocio Abia, Francisco Millan, Francisco J G Muriana, Sergio Montserrat-de la Paz
Grape (Vitis vinifera L.) seed has well-known potential for production of oil as a byproduct of winemaking and is a rich source of bioactive compounds. Herein, we report that the unsaponifiable fraction (UF) isolated from grape seed oil (GSO) possesses anti-oxidative and anti-inflammatory properties towards human primary monocytes. The UF isolated from GSO was phytochemically characterized by GC-MS and HPLC. Freshly obtained human monocytes were used to analyse the effects of GSOUF (10-100 μg mL-1) on oxidative and inflammatory responses using FACS analysis, RT-qPCR, and ELISA procedures...
April 17, 2018: Food & Function
https://www.readbyqxmd.com/read/29652441/reduction-of-5-hydroxymethylfurfural-formation-by-flavan-3-ols-in-maillard-reaction-models-and-fried-potato-chips
#19
Yajing Qi, Hao Zhang, Gangcheng Wu, Hui Zhang, Li Wang, Haifeng Qian, Xiguang Qi
BACKGROUND: 5-Hydroxymethylfurfural (HMF) is regarded as a thermal process contaminant in foods. Six flavan-3-ol fractions were isolated or semisynthesized from sorghum, cranberry and grape seed. Their unit compositions, interflavan linkages and degree of polymerization (DP) were characterized. The aim of this study was to investigate the effect of flavan-3-ols on the formation of HMF in chemical reaction models and fried potato chips. RESULTS: Results showed that all flavan-3-ols significantly mitigated the HMF formation at concentrations of 50, 100 and 200 μg mL-1 in chemical model system, and the inhibition was positively related to dose...
April 13, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29643994/grape-seed-procyanidin-extract-against-lung-cancer-the-role-of-microrna-106b-bioavailability-and-bioactivity
#20
Bingye Xue, Qing-Yi Lu, Larry Massie, Clifford Qualls, Jenny T Mao
MiR-106b is an oncomir and a potential target for anti-cancer therapy. We hypothesize that grape seed procyanidin extract (GSE) exerts antineoplastic effects on lung cancer through modulations of miR-106b and its downstream target. We found that GSE significantly down-regulated miR-106b in a variety of lung neoplastic cells and increased cyclin-dependent kinase inhibitor 1A ( CDKN1A ) mRNA and protein (p21) levels. Transfection of miR-106b mimics reversed the up-regulations of CDKN1A mRNA and p21, abrogated the GSE induced anti-proliferative and anti-invasive properties in lung cancer cells...
March 20, 2018: Oncotarget
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