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Melanocytic lesions

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https://www.readbyqxmd.com/read/28626949/diagnosis-and-treatment-of-concurrent-dermal-malignant-melanoma-and-melanocytomas-in-a-pygmy-hippopotamus-choeropsis-liberiensis
#1
Richard A Saunders, Rowena S Killick, Michelle G Barrows, Kelly A Bowlt, Daniella Denk
BACKGROUND: Dermal melanocytic neoplasms are common in some even-toed ungulates (Artiodactyla), yet this entity has not been reported in the pygmy hippopotamus to date. Concurrent occurrence of multiple benign and malignant melanocytic neoplasms is unusual. Malignant transformation occurs in a small percentage of benign melanocytic tumours in people but this phenomenon has not been well documented in animals. OBJECTIVES: To report the diagnosis and treatment of concurrent dermal melanocytomas and malignant melanomas in a pygmy hippopotamus...
June 18, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28622423/-congenital-dermatofibrosarcoma-protuberans-clinically-mimicking-a-melanocytic-nevus-treated-with-serial-excisions
#2
J Laske, M Sergon, T Mentzel, S Beissert, J Maschke
A 9-year-old female patient was referred to our department with the clinical diagnosis of a congenital melanocytic nevus on the back for serial excisions. The child's parents confirmed that the lesion existed since birth. Only little changes in color and size were observed over the years. The lesion was painless. This article is protected by copyright. All rights reserved.
June 16, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28614272/quantification-of-microrna-21-and-microrna-125b-in-melanoma-tissue
#3
Anne Wandler, Rikke Riber-Hansen, Henrik Hager, Stephen J Hamilton-Dutoit, Henrik Schmidt, Boye S Nielsen, Magnus Stougaard, Torben Steiniche
Although microRNAs (miRNAs) have emerged as potent mediators of melanoma development and progression, a precise understanding of their oncogenic role remains unclear. In this study, we analysed formalin-fixed and paraffin-embedded tissues from two separate melanoma cohorts and from a series of benign melanocytic nevi. Using three different quantification methods [array analysis, quantitative PCR (qPCR) and in-situ hybridization (ISH) quantified by digital image analysis], we found considerable miRNA dysregulation in tumours...
June 13, 2017: Melanoma Research
https://www.readbyqxmd.com/read/28612620/sampus-meltump-and-thimump-diagnostic-categories-characterized-by-uncertain-biological-behavior
#4
L Roncati, F Piscioli, T Pusiol
In the dermatopathological practice, there is a group of atypical melanocytic lesions with borderline histological features between benign simulants and malignant melanoma (MM), due to conflicting diagnostic criteria and inter-observer disagreement. In these cases, the dermatopathologist is authorized to seek consult with an established expert in the field, but even the most experienced specialist may not be sure about the correct diagnosis and the subsequent biological behavior. There is general consensus among qualified dermatopathologists that can be helpful to insert these ambiguous cases into two diagnostic categories: SAMPUS (Superficial Atypical Melanocytic Proliferations of Unknown Significance) and MELTUMP (MELanocytic Tumors of Uncertain Malignant Potential)...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28607685/concurrent-braf-and-pten-mutations-in-melanoma-of-unknown-origin-presenting-as-a-breast-mass
#5
Emmanuel Agosto-Arroyo, Marilin Rosa, Alec Chau, Laila Khazai
BACKGROUND: Metastases represent a small percentage of the malignancies affecting the breast, and only 5% of melanomas originate from non-cutaneous sites. Multiple genetic aberrations have been associated with the development of melanocytic lesions, including BRAF V600E mutation. Mutations in PTEN gene have also been related to the pathogenesis of multiple malignancies. PURPOSE/METHOD: This is the case of a 28-year-old female who presented with a tender, palpable mass in the upper outer quadrant of the right breast...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28607006/nr4a2-promotes-dna-double-strand-break-repair-upon-exposure-to-uvr
#6
Kelvin Yin, Yash Chhabra, Romain Tropée, Yi Chieh Lim, Mitchell Fane, Eloise Dray, Richard Sturm, Aaron G Smith
Exposure of melanocytes to ultraviolet radiation (UVR) induces the formation of UV-lesions that can produce deleterious effects in genomic DNA. Encounters of replication forks with unrepaired UV-lesions can lead to several complex phenomena, such as the formation of DNA double strand breaks (DSBs). The NR4A family of nuclear receptors are transcription factors that have been associated with mediating DNA repair functions downstream of the MC1R signalling pathway in melanocytes. In particular, emerging evidence shows that upon DNA damage, the NR4A2 receptor can translocate to sites of UV-lesion by mechanisms requiring post-translational modifications within the N-terminal domain and at a serine residue in the DNA biding domain at position 337...
June 12, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28605142/aberrant-expression-of-fli-1-in-melanoma
#7
Nisha Ramani, Phyu P Aung, Wen-Jen Hwu, Priyadharsini Nagarajan, Michael T Tetzlaff, Jonathan L Curry, Doina Ivan, Victor G Prieto, Carlos A Torres-Cabala
FLI-1 (Friend leukemia integration site 1) nuclear transcription factor has been proposed as a suitable tool in the differential diagnosis of small round cell sarcomas. It has also been described as nuclear marker of endothelial differentiation. Expression of FLI-1 has been demonstrated in Ewing's sarcoma/ primitive neuroectodermal tumor (ES/PNET) and vascular neoplasms. In the present study, we describe two cases of metastatic melanoma with small round blue cell morphology that showed strong nuclear expression of FLI-1...
June 12, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28602022/recurrence-of-melanocytic-lesions-after-laser-treatment-benign-versus-malignant-upon-dermoscopy
#8
S Guida, P L Bencini, A M Manganoni, R Gianotti, L Lospalluti, P Greco, G Pellacani, F Farnetani
The treatment of pigmented lesions includes several approaches depending on the nature of the cutaneous lesion to be treated. When considering melanocytic lesions, a balance between therapeutic aspects and cosmetic concerns for aesthetic sites have to be taken into account, with particular attention for the differential diagnosis between benign and malignant.(1-3) In particular, the increasing awareness for good cosmetic results lead to the development of less invasive techniques, although they hamper the histological assessment, which is the gold standard for the diagnosis of melanocytic lesions...
June 11, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28601392/histopathologic-features-of-melanoma-in-difficult-to-diagnose-lesions-a-case-control-study
#9
Manuel Lora Gonzalez, Eric D Young, James Bush, Katelyn McKenzie, Edgar Hunt, Viseslav Tonkovic-Capin, Melissa Jacobs, Michael Kucenic, Garth R Fraga
BACKGROUND: Dermatopathology is considered the gold standard for melanoma diagnosis, but a subset of cases is difficult to diagnose by histopathology. OBJECTIVE: The goals of this study were to measure the accuracy of histopathologic features in difficult-to-diagnose melanocytic tumors and the interobserver agreement of those features. METHODS: This is a case-control study of histopathologic features of melanoma in 100 difficult-to-diagnose melanocytic neoplasms (40 melanomas and 60 nevi)...
June 7, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28591278/comparisons-of-choroidal-nevus-measurements-obtained-using-10-and-20-mhz-ultrasound-and-spectral-domain-optical-coherence-tomography
#10
Maíra de França Martins, Kelcia Kiefer, Liliane Almeida Andrade Kanecadan, Patricia Novita Garcia, Rubens N Belfort, Norma Allemann
Purpose: To compare measurements of lesions clinically diagnosed as choroidal nevi using spectral domain optical coherence tomography (SD-OCT) and 10- and 20-MHz ultrasound (US). Methods: This prospective study, which was conducted between May 2011 and December 2011, evaluated eyes diagnosed with choroidal nevus via photographic documentation using 10- or 20-MHz A- and B-mode US (experienced examiner using both the transpalpebral technique and direct contact) or SD-OCT in the enhanced depth imaging mode (performed by a different examiner blinded to the US results)...
March 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28578648/synthetic-peptide-drugs-for-targeting-skin-cancer-malignant-melanoma-and-melanotic-lesions
#11
Alex Eberle, Bhimsen Rout, Mei Bigliardi Qi, Paul L Bigliardi
Peptides play decisive roles in the skin, ranging from host defense responses to various forms of neuroendocrine regulation of cell and organelle function. Synthetic peptides conjugated to radionuclides or photosensitizers may serve to identify and treat skin tumors and their metastatic forms in other organs of the body. In the introductory part of his review, the role and interplay of the different peptides in the skin is briefly summarized, including their potential application for the management of frequently occurring skin cancers...
June 4, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28577207/vitiligo-an-update-on-pathophysiology-and-treatment-options
#12
REVIEW
Reinhart Speeckaert, Nanja van Geel
The pathophysiology of vitiligo is becoming increasingly clarified. In non-segmental vitiligo, early factors include activation of innate immunity, inflammasome activation, oxidative stress, and loss of melanocyte adhesion. Nonetheless, the main mechanism leading to non-segmental vitiligo involves an immune-mediated destruction of melanocytes. Anti-melanocyte-specific cytotoxic T cells exert a central role in the final effector stage. Genetic research revealed a multi-genetic inheritance displaying an overlap with other autoimmune disorders...
June 2, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28570000/morphological-and-molecular-characterization-of-actinic-lentigos-reveals-alterations-of-the-dermal-extracellular-matrix
#13
E Warrick, C Duval, S Nouveau, P Bastien, V Piffaut, B Chalmond, J-P Ortonne, O de Lacharrière, F Bernerd
BACKGROUND: Actinic lentigos (AL) are benign hyperpigmented skin lesions associated with photoageing. Despite their high prevalence, biological mechanisms driving their formation remain unclear. OBJECTIVES: To provide new insights about the physiopathology of AL through a comprehensive description of their histological and molecular features. METHODS: Quantitative analysis of dermoscopic images was used to select AL containing elongated patterns, predicted to display a highly deformed dermal-epidermal junction (DEJ), on the back of hands of 15 Caucasian women...
June 1, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28567312/intracorneal-hematoma-showing-clinical-and-dermoscopic-features-of-acral-lentiginous-melanoma
#14
Ugur Uslu, Franz Heppt, Michael Erdmann
Intra- and subcorneal hematoma, a skin alteration seen palmar and plantar after trauma or physical exercise, can be challenging to distinguish from in situ or invasive acral lentiginous melanoma. Thus, careful examination including dermoscopic and histologic assessment may be necessary to make the correct diagnosis. We here present a case of a 67-year-old healthy female patient who presented with a pigmented plantar skin alteration. Differential diagnoses included benign skin lesions, for example, hematoma or melanocytic nevus, and also acral lentiginous melanoma or melanoma in situ...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/28565919/age-and-anatomical-location-related-dermoscopic-patterns-of-210-acral-melanocytic-nevi-in-a-turkish-population
#15
Nazan Emiroglu, Fatma Pelin Cengiz, Nahide Onsun
BACKGROUND: Dermoscopy is a useful tool for earlier diagnosis and differentiating benign lesions from melanoma. OBJECTIVES: We aim to investigate dermoscopic features of acral nevi, age, and localisation-related findings of these lesions. METHODS: This was an observational, descriptive study. Patients were retrospectively collected from the Department of Dermatology. The patients with acral nevi were included in the study. Inclusion criteria were Turkish nationality and the presence of at least 1 acral nevus diagnosed both clinically and dermoscopically...
May 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28564685/histopathologic-and-immunohistochemical-correlates-of-confocal-descriptors-in-pigmented-facial-macules-on-photodamaged-skin
#16
Ignacio Gómez-Martín, Sara Moreno, Evelyn Andrades-López, Inma Hernández-Muñoz, Fernando Gallardo, Carlos Barranco, Ramon M Pujol, Sonia Segura
Importance: Pigmented facial macules on photodamaged skin are a clinical, dermoscopic, and histopathologic challenge. Objectives: To clinically and dermoscopically characterize, by means of reflectance confocal microscopy (RCM), ambiguous pigmented facial macules and establish a correlation between RCM, histopathologic, and immunohistochemical findings. Design, Setting, and Participants: A prospective study of ambiguous pigmented facial macules on photodamaged skin was conducted in a tertiary referral center for dermatology between January 1, 2009, and December 31, 2015...
May 31, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28562195/mhealth-app-for-risk-assessment-of-pigmented-and-nonpigmented-skin-lesions-a-study-on-sensitivity-and-specificity-in-detecting-malignancy
#17
Monique Thissen, Andreea Udrea, Michelle Hacking, Tanja von Braunmuehl, Thomas Ruzicka
BACKGROUND: With the advent of smartphone devices, an increasing number of mHealth applications that target melanoma identification have been developed, but none addresses the general context of melanoma and nonmelanoma skin cancer identification. INTRODUCTION: In this study a smartphone application using fractal and classical image analysis for the risk assessment of skin lesions is systematically evaluated to determine its sensitivity and specificity in the diagnosis of melanoma and nonmelanoma skin cancer along with actinic keratosis and Bowen's disease...
May 31, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28544808/the-first-transepidermal-transplantation-of-non-cultured-epidermal-suspension-using-a-dermarolling-system-in-vitiligo-a-sequential-histological-and-clinical-study
#18
L Benzekri, Y Gauthier
The current methods for melanocyte delivery to depigmented skin are invasive and often require sophisticated approaches. Here we describe a promising simple and minimally invasive technique based on the dermarolling system. The technique involves preparation of a keratinocyte/melanocyte suspension prepared by trypsinization from a non-lesioned part of a patient's scalp skin and transepidermal delivery using a dermaroller equipped with 0.2 mm needles. Dermarolling leads to epidermal microinjuries without, however, causing pain or inflammation...
May 19, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28543665/immunohistochemical-evaluation-of-epidermal-proliferation-differentiation-and-melanocytic-density-in-symmetrical-acrokeratoderma
#19
P-P Yang, J Peng, Y-Y Wu, Z Liu, P Sheng, Y Zhou, S-J Li, Y-M Fan
BACKGROUND: Symmetrical acrokeratoderma (SAK) is characterized by brown to black hyperkeratotic patches on acral regions. Although epidermal hyperkeratosis and acanthosis are consistent pathological changes, the nature of epidermal hyperplasia is unknown. AIM: To evaluate epidermal proliferation and differentiation and melanocytic density in skin lesions of SAK. METHODS: Expression of keratin 10 (K10), K14, K16, involucrin, filaggrin, Ki-67, and Melan-A was detected by immunohistochemistry in eight patients with SAK, seven patients with ichthyosis vulgaris (IV) and six healthy controls (HCs)...
May 22, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28543606/reflectance-confocal-microscopy-analysis-of-equivocal-melanocytic-lesions-with-severe-regression
#20
M Agozzino, A Ferrari, C Cota, C Franceschini, P Buccini, L Eibenshutz, M Ardigò
BACKGROUND: The differential diagnosis between regressing nevi and melanoma might be challenging; regressing areas can represent a confounding factor for the diagnosis and the histology still remain mandatory to rule out melanoma. Reflectance confocal microscopy may add valuable information by revealing features suggestive of the nature of the melanocytic proliferation. OBJECTIVE: To assess the impact of confocal microscopy in the management of regressive melanocytic lesions...
May 21, 2017: Skin Research and Technology
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