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https://www.readbyqxmd.com/read/29139361/angiokeratoma-of-the-glans-penis
#1
Bryce D Beutler, Philip R Cohen
Angiokeratomas are benign vascular lesions characterized by ectatic blood vessels in the papillary dermis with overlying acanthosis and hyperkeratosis, often occurring as idiopathic scrotal tumor and rarely as penile lesions. Twelve men, including our case of a 58-year-old white man, have been reported with angiokeratomas of the glans penis. The lesions typically present as asymptomatic dome-shaped papules ranging in size from 0.5 to 5 mm and present as red, purple, blue, or black lesions along the penile coronal rim...
2017: Skinmed
https://www.readbyqxmd.com/read/29138058/the-diagnostic-value-and-histologic-correlate-of-distinct-patterns-of-shiny-white-streaks-for-the-diagnosis-of-melanoma-a-retrospective-case-control-study
#2
Anna Eliza Verzi, Victor L Quan, Kara Walton, Mary C Martini, Ashfaq A Marghoob, Erin M Garfield, Betty Kong, Maria Cristina Isales, Timothy VandenBoom, Bin Zhang, Dennis West, Pedram Gerami
BACKGROUND: Shiny white streaks (SWS) are best visualized with polarized dermoscopy, and correlate with dermal fibroplasia histopathologically. SWS have been described at higher frequencies in melanomas than benign nevi. OBJECTIVE: We assessed the diagnostic value of different patterns of SWS and their histologic correlate in melanocytic lesions. METHODS: Polarized dermoscopic images of 1507 histopathologically diagnosed melanocytic neoplasms were analyzed for presence and pattern of SWS...
November 11, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29138054/keratinocyte-sonic-hedgehog-up-regulation-drives-the-development-of-giant-congenital-nevi-via-paracrine-endothelin-1-secretion
#3
Arash Chitsazan, Blake Ferguson, Rehan Villani, Herlina Y Handoko, Pamela Mukhopadhyay, Brian Gabrielli, Wolter J Mooi, H Peter Soyer, Duncan Lambie, Kiarash Khosrotehrani, Grant Morahan, Graeme J Walker
Giant congenital nevi are associated with clinical complications such as neurocutaneous melanosis and melanoma. Virtually nothing is known about why some individuals develop these lesions. We previously identified the sonic hedgehog (Shh) pathway regulator Cdon as a candidate nevus modifier gene. Here we validate this by studying Cdon knockout mice, and go on to establishment the mechanism by which Shh exacerbates nevogenesis. Cdon knockout mice develop blue nevi without the need for somatic melanocyte oncogenic mutation...
November 11, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29132722/trajectories-of-premalignancy-during-the-journey-from-melanocyte-to-melanoma
#4
REVIEW
Andrew J Colebatch, Richard A Scolyer
A stepwise progression from melanocytic precursors to cutaneous melanoma is a well-established model, based on decades of careful observation and morphological analysis. The steps identified are benign melanocytic naevus, dysplastic naevus, 'radial growth phase' melanoma (including melanoma in situ) and 'vertical growth phase' melanoma (also termed tumourigenic melanoma). Recent genomic data have refined the understanding of the steps of melanoma development and their relationship to one another. These data support the existence of dysplastic naevi as distinct lesions; suggest the importance of clonal dynamics in the precursor steps of melanoma; and confirm the carcinogenic role of ultraviolet radiation throughout early melanoma development and progression...
November 10, 2017: Pathology
https://www.readbyqxmd.com/read/29128957/expression-of-glut-1-in-malignant-melanoma-and-melanocytic-nevi-an-immunohistochemical-study-of-400-cases
#5
Miroslav Důra, Kristýna Němejcová, Radek Jakša, Michaela Bártů, Ondřej Kodet, Ivana Tichá, Romana Michálková, Pavel Dundr
The glucose transporter-1 (Glut-1) is a cell membrane glycoprotein involved in glucose uptake. An increased expression of Glut-1 is an important cell adaptation mechanism against hypoxia. An upregulation of Glut-1 can be found in several types of malignant tumors, which are able to reprogram their metabolism from oxidative phosphorylation to aerobic glycolysis (Warburg effect). However, the data regarding melanocytic lesions is equivocal. We performed comprehensive immunohistochemical analysis of the Glut-1 expression in 225 malignant melanomas (MM) and 175 benign nevi...
November 11, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29126970/malignant-melanoma-presenting-as-amelanotic-caruncular-lesion-in-a-child
#6
Alexander R Walters, Katie M Keck, Oliver Simmons, Sarah G Williams, Stephen Cross, Rakesh M Patel
Conjunctival melanoma is a relatively rare malignant neoplasm that can present in childhood in any part of the conjunctiva. The infrequency with which conjunctival melanoma is encountered in childhood caruncular lesions makes it a formidable but important aspect of the differential diagnosis. We report the case of a 10-year-old boy who presented with a left caruncular lesion. On histopathologic analysis, the lesion was determined to be BRAF-negative invasive melanoma arising in association with melanocytic nevus...
November 7, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29125708/integration-of-dermoscopy-and-reflectance-confocal-microscopy-for-distinguishing-melanomas-from-nevi-of-the-breast-area
#7
V D Mandel, C Bombonato, R Pampena, A Kyrgidis, S Borsari, E Benati, M Mirra, S Piana, G Pellacani, C Longo
BACKGROUND: Nevi of special sites encompass a class of benign lesions characterized by the presence of atypical clinical and histopathologic features that can be difficult to distinguish from melanoma. Dermoscopy and reflectance confocal microscopy may improve the clinical assessment of melanocytic lesions in order to avoid unnecessary excisions. OBJECTIVES: The aim of this study was to assess the value of specific dermoscopic and confocal criteria in distinguishing melanomas from nevi of the breast area...
November 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29118524/collision-tumor-between-trichofolliculoma-and-melanocytic-nevus
#8
Christel Bolte, Roberto Cullen, Ivo Sazunic
Trichofolliculoma (TF) is a hamartomatous hair follicle-related tumor, clinically described as a dome-shaped papule with a central pore crossed by one or more silky white hairs. Histologically, it described as a cystic cavity containing keratinous debris, hair shaft fragments, and numerous hair follicles arising from its linings. Collision or compound tumors are a coexistence of two or more identifiable tumors in the same lesion. We present a case of a 47-year-old man with a lesion on his left cheek clinically characterized as a TF...
October 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/29117718/deep-tissue-sequencing-using-augmented-intelligence-to-probe-melanocytic-lesions
#9
John Arlette, Alexander Wong, Iman Khodadad, Farnoud Kazemzadeh
No abstract text is available yet for this article.
November 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29115737/reinterpreting-dermoscopic-pigment-network-with-reflectance-confocal-microscopy-for-identification-of-melanoma-specific-features
#10
B De Pace, F Farnetani, A Losi, S Ciardo, N De Carvalho, Anna M Cesinaro, L Reggiani Bonetti, J Chester, S Kaleci, E Del Duca, Steven P Nisticò, C Longo, G Pellacani
BACKGROUND: Pigment network is an important dermoscopic features for melanocytic lesions but alterations in grid line thickness are also observed in melanomas. OBJECTIVE: To investigate features of thick, thin and mixed pigment networks at dermoscopy and their respective features at Reflectance Confocal Microscopy (RCM) for differential diagnosis, correlated with histology METHODS: All melanocytic lesions with histological diagnosis, evaluated between January 2010 - May 2014, were enrolled and classified according to dermoscopy evaluation of the pigment network; thin, thick and mixed...
November 8, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29111820/identification-of-feeder-vessels-in-ocular-surface-neoplasia-using-indocyanine-green-angiography
#11
Matthias Brunner, Bernhard Steger, Vito Romano, Martin Hodson, Yalin Zheng, Heinrich Heimann, Stephen B Kaye
PURPOSE: To evaluate indocyanine green angiography (ICGA) for the identification and characterization of afferent (feeding) and efferent (draining) vessels in patients with ocular surface neoplasia. MATERIALS AND METHODS: Consecutive patients with biopsy-proven benign, pre-invasive, or invasive ocular surface tumors of the bulbar conjunctiva were included. Patients underwent anterior segment optical coherence tomography, ICGA, and color photography for the evaluation of the thickness, location, number, and diameter of afferent and efferent vessels of the lesions...
November 7, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29109715/specific-detection-of-serum-antibodies-against-bkpyv-a-small-dna-tumour-virus-in-patients-affected-by-choroidal-nevi
#12
Silvia Pietrobon, Ilaria Bononi, Francesca Lotito, Paolo Perri, Sara Violanti, Elisa Mazzoni, Fernanda Martini, Mauro G Tognon
Ocular or choroidal nevus (CN) is a rare benign neoplastic lesion of the eye. The cause of CN onset/progression, which arises from the transformation of ocular melanocytes, is not known. A fraction of CN patients may develop uveal melanoma. The objective of this study was to investigate the association between CN and BK polyomavirus (BKPyV), a small DNA tumor virus. Serum IgG antibodies which react with BKPyV antigens were analyzed. An indirect E.L.I.S.A. using synthetic peptides that mimic BKPyV antigens was employed...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29100006/location-location-location-spatio-temporal-cues-that-define-the-cell-of-origin-in-melanoma
#13
Maria S Soengas, E Elizabeth Patton
It is unclear whether melanoma initiates from mature melanocytes or stem cell precursors. In this issue of Cell Stem Cell, Moon et al. (2017) and Köhler et al. (2017) use in vivo lineage tracing to demonstrate that these two possibilities may occur downstream of the same pro-tumorigenic lesions, depending on environmental factors or the anatomical location.
November 2, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/29095741/eccrine-centric-melanocytic-nevus
#14
Raymond M Fertig, Adar Berghoff, Jessica Cervantes, Evan Darwin, Drazen Jukic
Benign melanocytic neoplasms present with a diverse array of well-known histopathologic patterns. It is imperative to recognize the benign patterns to render accurate diagnoses. We describe here an interesting and hitherto not described low-power architectural pattern of a benign melanocytic lesion: eccrine-centric melanocytic nevus. The patient was a 50-year-old African American woman who noticed a new mole on her foot that began as a dark speck but quickly grew larger. The lesion was excised to exclude the possibility of melanoma...
October 27, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29094145/population-based-analysis-of-histologically-confirmed-melanocytic-proliferations-using-natural-language-processing
#15
Jason P Lott, Denise M Boudreau, Ray L Barnhill, Martin A Weinstock, Eleanor Knopp, Michael W Piepkorn, David E Elder, Steven R Knezevich, Andrew Baer, Anna N A Tosteson, Joann G Elmore
Importance: Population-based information on the distribution of histologic diagnoses associated with skin biopsies is unknown. Electronic medical records (EMRs) enable automated extraction of pathology report data to improve our epidemiologic understanding of skin biopsy outcomes, specifically those of melanocytic origin. Objective: To determine population-based frequencies and distribution of histologically confirmed melanocytic lesions. Design, Setting, and Participants: A natural language processing (NLP)-based analysis of EMR pathology reports of adult patients who underwent skin biopsies at a large integrated health care delivery system in the US Pacific Northwest from January 1, 2007, through December 31, 2012...
November 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29080681/uncoupling-of-er-mitochondrial-oxidative-stress-in-mtorc1-hyperactivation-associated-skin-hypopigmentation
#16
Fei Yang, Lingli Yang, Mari Wataya-Kaneda, Takuji Yoshimura, Atsushi Tanemura, Ichiro Katayama
Accumulating evidence has described the involvement of mTOR complex 1 (mTORC1) signaling in pigmentation regulation; however, the precise mechanism is not fully understood. Here, we generated mice with conditional deletion of the mTORC1 suppressor tuberous sclerosis complex 2 (Tsc2) in melanocytes. It resulted in constitutive hyperactivation of mTORC1 and reduced skin pigmentation. Mechanistically, neither the number of melanocytes nor the expression of melanogenesis-related enzymes was decreased; however, endoplasmic reticulum (ER) and mitochondrial oxidative stress, and lower melanization in melanosomes were observed...
October 25, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29072181/primary-clear-cell-sarcoma-of-the-dermis-mimicking-malignant-melanoma
#17
Ifeyinwa E Obiorah, Pauline Brenholz, Metin Özdemirli
BACKGROUND: Clear cell sarcoma is a rare malignant soft tissue neoplasm that typically involves tendons and aponeurosis. Clear cell sarcoma occurring in the dermis is an extremely rare occurrence. It is difficult to differentiate between this neoplasm and dermal malignant melanoma because they both have similar morphologic and immunohistochemical features. Although rare, clear cell sarcoma of the skin typically occur in the extremities. To our knowledge, there are no reported cases of primary clear cell sarcoma of the skin occurring in the neck...
October 26, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/29071272/conjunctival-blue-naevus-in-an-anophthalmic-socket
#18
Hibba Quhill, Paul A Rundle, Hardeep Singh Mudhar
PURPOSE OF THE STUDY: To describe an unusual brown pigmented lesion of the conjunctiva in an anophthalmic socket in a 16-year-old male. PROCEDURES: A 16-year-old male patient presented with socket irritation whilst wearing an artificial eye due to meibomian gland dysfunction. An area of flat, subepithelial, dark brown pigmentation with irregular and indistinct borders on the bulbar conjunctiva of the anophthalmic socket was seen. The patient believed it had been present for at least 2 years...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29059147/atypical-melanocytic-proliferations-a-review-of-the-literature
#19
Courtney J Ensslin, Brian P Hibler, Erica H Lee, Kishwer S Nehal, Klaus J Busam, Anthony M Rossi
BACKGROUND: Ambiguous histopathologic diagnoses represent a challenge for clinicians because of a lack of definitive diagnosis and related uncertainty about management. OBJECTIVE: To review the literature on atypical melanocytic proliferations and detail synonymous terms, epidemiology, diagnostic work-up, histopathology, treatment, and prognosis. METHODS: Databases from PubMed and Web of Science were searched for articles related to atypical melanocytic proliferations...
October 20, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29057565/spectrophotometer-is-useful-for-assessing-vitiligo-and-chemical-leukoderma-severity-by-quantifying-color-difference-with-surrounding-normally-pigmented-skin
#20
M Hayashi, K Okamura, Y Araki, M Suzuki, T Tanaka, Y Abe, S Nakano, J Yoshizawa, Y Hozumi, M Inoie, T Suzuki
BACKGROUND: Acquired skin hypopigmentation has many etiologies, including autoimmune melanocyte destruction, skin aging, inflammation, and chemical exposure. Distinguishing lesions from normally pigmented skin is clinically important to precisely assess disease severity. However, no gold standard assessment method has been reported. We aimed to investigate whether spectrophotometers are useful for assessing vitiligo and rhododendrol (4-(4-hydroxyphenol)-2-butanol) (Rhododenol(®) )-induced leukoderma disease severity by quantifying skin color...
October 22, 2017: Skin Research and Technology
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