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https://www.readbyqxmd.com/read/28589906/loss-of-calponin-h1-confers-anoikis-resistance-and-tumor-progression-in-the-development-of-high-grade-serous-carcinoma-originating-from-the-fallopian-tube-epithelium
#1
Kai-Hung Wang, Sung-Chao Chu, Tang-Yuan Chu
Increasing evidence indicates that ovarian high-grade serous carcinoma (HGSC) originates from the fallopian tube epithelium and metastasizes to the ovary as the secondary site. A working hypothesis is that detached tubal HGSC cells survive anoikis and implant on the ovary. In this study, we found that downregulation of calponin h1 (CNN1) is necessary for the anoikis survival and cell transformation. CNN1 was progressively downregulated in cells and tissues representing different stages of HGSC development from fallopian tube epithelium (FTE)...
May 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28571127/physicochemical-characteristics-of-rat-muscle-glycogen-fractions
#2
Zahra Ghafouri, Mehdi Rasouli
INTRODUCTION: Homogenization of animal tissues with cold Perchloric Acid (PCA) produces two fractions of glycogen, Acid Soluble Glycogen (ASG) and Acid Insoluble Glycogen (AIG). AIM: To determine some physicochemical characteristics of muscle glycogen fractions in two groups of rat. MATERIALS AND METHODS: An experimental study was conducted on two groups of five male rats. Rats in control group were kept at rest and in case group on 30 minutes physical activity...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28522403/multiplex-autoantibody-detection-for-autoimmune-liver-diseases-and-autoimmune-gastritis
#3
Joris Vanderlocht, Mart van der Cruys, Frans Stals, Liesbeth Bakker-Jonges, Jan Damoiseaux
Autoantibody detection for autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and autoimmune gastritis (AIG) is traditionally performed by IIF on a combination of tissues. Multiplex line/dot blots (LIA/DIA) offer multiple advantages, i.e. automation, objective reading, no interfering reactivities, no coincidental findings. In the current study we evaluated automated DIA (D-Tek) for detecting autoantibodies related to autoimmune diseases of the gastrointestinal tract. We tested samples of the Dutch EQC program and compared the results with the consensus of the participating labs...
May 16, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28511372/comparison-of-methods-to-assay-liver-glycogen-fractions-the-effects-of-starvation
#4
Nastaran Mojibi, Mehdi Rasouli
INTRODUCTION: There are several methods to extract and measure glycogen in animal tissues. Glycogen is extracted with or without homogenization by using cold Perchloric Acid (PCA). AIM: Three procedures were compared to determine glycogen fractions in rat liver at different physiological states. MATERIALS AND METHODS: The present study was conducted on two groups of rats, one group of five rats were fed standard rodent laboratory food and were marked as controls, and another five rats were starved overnight (15 hour) as cases...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28505756/interaction-of-airy-gaussian-beams-in-photonic-lattices-with-defects
#5
Zhiwei Shi, Jing Xue, Xing Zhu, Ying Xiang, Huagang Li
We investigate numerically the interaction between two finite Airy-Gaussian (AiG) beams in different media with the defected photonic lattices in one transverse dimension. We discuss that the beams with different intensities and phases launch into the different lattice structures but accelerate in opposite directions. During interactions, the interference fringe, breathers, and soliton pairs are observed. In the linear media, the initial deflection direction of the accelerated beams is changed by adjusting the phase shift and the beam interval...
April 2017: Physical Review. E
https://www.readbyqxmd.com/read/28448114/comparison-of-ag-in-ga-se2-mo-and-cu-in-ga-se2-mo-interfaces-in-solar-cells
#6
Xianfeng Zhang, Masakazu Kobayashi, Akira Yamada
The structural and electrical properties of the junction at Ag(In,Ga)Se2AIGS/Mo, and Cu(In,Ga)Se2 CIGS/Mo layers were characterized. The region between the CIGS and Mo featured a MoSe2 layer with a layered hexagonal structure and thickness of 10-15 nm. The c-axis of the MoSe2 was oriented perpendicular to the Mo layer, and the c -value was 12.6 Å. However, no such layer was observed at the interface between AIGS and Mo. This result was also confirmed by energy-dispersive X-ray spectrometry and X-ray diffraction measurements of the MoSe2 layer...
May 5, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28405320/distinct-metaplastic-and-inflammatory-phenotypes-in-autoimmune-and-adenocarcinoma-associated-chronic-atrophic-gastritis
#7
Sangho Jeong, Eunyoung Choi, Christine P Petersen, Joseph T Roland, Alessandro Federico, Rossana Ippolito, Francesco P D'Armiento, Gerardo Nardone, Osamu Nagano, Hideyuki Saya, Marco Romano, James R Goldenring
BACKGROUND: Autoimmune gastritis (AIG) and adenocarcinoma-associated chronic atrophic gastritis (CAG) are both associated with oxyntic atrophy, but AIG patients demonstrate an increased risk of carcinoid tumors rather than the elevated risk of adenocarcinoma observed with CAG. We therefore sought to compare the characteristics of the metaplastic mucosa in AIG and CAG patients. METHODS: We examined markers for metaplasia (spasmolytic polypeptide expressing metaplasia (SPEM) and intestinal metaplasia) as well as proliferation (Ki67) and immune cell populations (neutrophils, macrophages, and eosinophils) in gastric sections from 16 female patients with autoimmune thyroiditis and AIG and 17 patients with CAG associated with gastric adenocarcinoma...
February 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28276835/autoimmune-gastritis-relationships-with-anemia-and-helicobacter-pylori-status
#8
Vincenzo Villanacci, Giovanni Casella, Francesco Lanzarotto, Camillo Di Bella, Angelo Sidoni, Moris Cadei, Tiziana Salviato, Maria Pina Dore, Gabrio Bassotti
BACKGROUND: Autoimmune gastritis (AIG) is a gastric pathologic condition affecting the mucosa of the fundus and the body and eventually leading to hypo-achlorhydria. AIMS: We report our clinical and pathological experience with AIG. METHODS: Data from patients with a diagnosis of AIG seen in the period January 2002-December 2012 were retrieved. Only patients with complete sets of biopsies were analyzed. RESULTS: Data from 138 patients were available for analysis...
June 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28263100/decreased-serum-dnase1-activity-in-patients-with-autoimmune-liver-diseases
#9
Nikolaos K Gatselis, Aigli G Vakrakou, Kalliopi Zachou, Theodoros Androutsakos, Kalliopi Azariadis, Gregorios Hatzis, Menelaos N Manoussakis, George N Dalekos
Deoxyribonuclease1 (DNase1) is involved in chromatin degradation of apoptotic cells. Its deficiency results in accumulation of self-DNA, which in turn may induce inflammation and autoimmunity. We assessed for the first time serum DNase1-activity in a large consecutive cohort of treatment-naïve patients with autoimmune liver diseases (ALD). DNase1-activity was determined by single radial enzyme-diffusion (SRED) at diagnosis of 224 patients with autoimmune hepatitis (AIH), 249 with primary biliary cirrhosis (PBC) and 36 with primary sclerosing cholangitis (PSC)...
March 2017: Autoimmunity
https://www.readbyqxmd.com/read/28051264/homogenization-versus-homogenization-free-method-to-measure-muscle-glycogen-fractions
#10
N Mojibi, M Rasouli
OBJECTIVE: The glycogen is extracted from animal tissues with or without homogenization using cold perchloric acid. Three methods were compared for determination of glycogen in rat muscle at different physiological states. MATERIALS AND METHODS: Two groups of five rats were kept at rest or 45 minutes muscular activity. The glycogen fractions were extracted and measured by using three methods. RESULTS: The data of homogenization method shows that total glycogen decreased following 45 min physical activity and the change occurred entirely in acid soluble glycogen (ASG), while AIG did not change significantly...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27983504/analysis-of-anthrax-immune-globulin-intravenous-with-antimicrobial-treatment-in-injection-drug-users-scotland-2009-2010
#11
Xizhong Cui, Leisha D Nolen, Junfeng Sun, Malcolm Booth, Lindsay Donaldson, Conrad P Quinn, Anne E Boyer, Katherine Hendricks, Sean Shadomy, Pieter Bothma, Owen Judd, Paul McConnell, William A Bower, Peter Q Eichacker
We studied anthrax immune globulin intravenous (AIG-IV) use from a 2009-2010 outbreak of Bacillus anthracis soft tissue infection in injection drug users in Scotland, UK, and we compared findings from 15 AIG-IV recipients with findings from 28 nonrecipients. Death rates did not differ significantly between recipients and nonrecipients (33% vs. 21%). However, whereas only 8 (27%) of 30 patients at low risk for death (admission sequential organ failure assessment score of 0-5) received AIG-IV, 7 (54%) of the 13 patients at high risk for death (sequential organ failure assessment score of 6-11) received treatment...
January 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27981542/extraction-of-glycogen-on-mild-condition-lacks-aig-fraction
#12
Z Ghafouri, M Rasouli
OBJECTIVE: Extraction of animal tissues with cold water or perchloric acid yields less glycogen than is obtained with hot-alkaline. Extraction with acid and alkaline gives two fractions, acid soluble (ASG) and insoluble glycogen (AIG). The aim of this work is to examine the hypothesis that not all liver glycogen is extractable by Tris-buffer using current techniques. MATERIALS AND METHODS: Rat liver was homogenized with Tris-buffer pH 8.3 and extracted for the glycogen fractions, ASG and AIG...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27836013/novel-genetic-risk-variants-for-pediatric-celiac-disease
#13
Angeliki Balasopoulou, Biljana Stanković, Angeliki Panagiotara, Gordana Nikčevic, Brock A Peters, Anne John, Effrosyni Mendrinou, Apostolos Stratopoulos, Aigli Ioanna Legaki, Vasiliki Stathakopoulou, Aristoniki Tsolia, Nikolaos Govaris, Sofia Govari, Zoi Zagoriti, Konstantinos Poulas, Maria Kanariou, Nikki Constantinidou, Maro Krini, Kleopatra Spanou, Nedeljko Radlovic, Bassam R Ali, Joseph Borg, Radoje Drmanac, George Chrousos, Sonja Pavlovic, Eleftheria Roma, Branka Zukic, George P Patrinos, Theodora Katsila
BACKGROUND: Celiac disease is a complex chronic immune-mediated disorder of the small intestine. Today, the pathobiology of the disease is unclear, perplexing differential diagnosis, patient stratification, and decision-making in the clinic. METHODS: Herein, we adopted a next-generation sequencing approach in a celiac disease trio of Greek descent to identify all genomic variants with the potential of celiac disease predisposition. RESULTS: Analysis revealed six genomic variants of prime interest: SLC9A4 c...
October 24, 2016: Human Genomics
https://www.readbyqxmd.com/read/27831639/improvement-of-the-classical-assay-method-for-liver-glycogen-fractions-asg-is-the-main-and-metabolic-active-fraction
#14
H Shokri-Afra, A Ostovar-Ravari, M Rasouli
OBJECTIVE: Acid digestion of animal tissues yields two fractions of glycogen, acid soluble (ASG) and insoluble (AIG). The current study was performed to improve the assay method for glycogen fractions in rat liver in different physiological states. MATERIALS AND METHODS: All steps of the assay were manipulated and optimized to measure the content of ASG and AIG in fed and starved rat liver. RESULTS: In postmortem liver tissue, total glycogen was decreased slowly at 4°C and rapidly at 25°C but was well stabilized at -20°C and -70°C...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27680508/micro-ct-evaluation-of-ceramic-inlays-comparison-of-the-marginal-and-internal-fit-of-five-and-three-axis-cam-systems-with-a-heat-press-technique
#15
Norah K Alajaji, David Bardwell, Matthew Finkelman, Ala Ali
OBJECTIVES: To evaluate the marginal and internal adaptation of CAD/CAM lithium-disilicate inlay restorations fabricated by two milling systems (Five and Three-axis), and a traditional heat-press technique. METHODS: Fifteen premolar teeth with an MOD cavity preparation were fabricated. Lithium-disilicate inlay restorations were obtained by three fabrication techniques and fitted to their dies (n = 15/gp) as follows: Group-1, three-axis milling system, Group-2, five-axis milling system, Group-3, conventional heat-press technique...
September 29, 2016: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/27651070/baseline-fourier-domain-optical-coherence-tomography-structural-risk-factors-for-visual-field-progression-in-the-advanced-imaging-for-glaucoma-study
#16
MULTICENTER STUDY
Xinbo Zhang, Anna Dastiridou, Brian A Francis, Ou Tan, Rohit Varma, David S Greenfield, Joel S Schuman, Mitra Sehi, Vikas Chopra, David Huang
PURPOSE: To identify baseline structural parameters that predict the progression of visual field (VF) loss in patients with open-angle glaucoma. DESIGN: Multicenter cohort study. METHODS: Participants from the Advanced Imaging for Glaucoma (AIG) study were enrolled and followed up. VF progression is defined as either a confirmed progression event on Humphrey Progression Analysis or a significant (P < .05) negative slope for VF index (VFI)...
December 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27394849/morphometric-and-preliminary-genetic-characteristics-of-branchinecta-orientalis-populations-from-iran-crustacea-anostraca
#17
Behroz Atashbar, Naser Agh, Ramin Manaffar, Gilbert Van Stappen, Ali Mohamadyari, Johan Mertens, Lynda Beladjal
Branchinecta orientalis is a fairy shrimp endemic to the Palearctic region, from Mongolia to Spain. The patchy nature of its habitat is thought to result in a high degree of subdivision among populations, potentially promoting speciation. We combined morphometric characteristics with molecular phylogeny of cytochrome c oxidase I (COI) to test whether B. orientalis could be a species complex and whether there is any correlation between the genetic variation, morphometric characteristics and geographical variables...
May 5, 2016: Zootaxa
https://www.readbyqxmd.com/read/27259856/regulatory-t-cells-control-th2-dominant-murine-autoimmune-gastritis
#18
Jessica Harakal, Claudia Rival, Hui Qiao, Kenneth S Tung
Pernicious anemia and gastric carcinoma are serious sequelae of autoimmune gastritis (AIG). Our study indicates that in adult C57BL/6-DEREG mice expressing a transgenic diphtheria toxin receptor under the Foxp3 promoter, transient regulatory T cell (Treg) depletion results in long-lasting AIG associated with both H(+)K(+)ATPase and intrinsic factor autoantibody responses. Although functional Tregs emerge over time during AIG occurrence, the effector T cells rapidly become less susceptible to Treg-mediated suppression...
July 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27259263/hexokinase-2-promotes-tumor-growth-and-metastasis-by-regulating-lactate-production-in-pancreatic-cancer
#19
Marybeth Anderson, Raoud Marayati, Richard Moffitt, Jen Jen Yeh
Pancreatic ductal adenocarcinoma (PDAC) is a KRAS-driven cancer with a high incidence of metastasis and an overall poor prognosis. Previous work in a genetically engineered mouse model of PDAC showed glucose metabolism to be important for maintaining tumor growth. Multiple glycolytic enzymes, including hexokinase 2 (HK2), were upregulated in primary PDAC patient tumors, supporting a role for glycolysis in promoting human disease. HK2 was most highly expressed in PDAC metastases, suggesting a link between HK2 and aggressive tumor biology...
June 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27040980/androgen-inducible-gene-1-increases-the-er-ca-2-content-and-cell-death-susceptibility-against-oxidative-stress
#20
Nadine Nickel, Astrid Cleven, Vitalij Enders, Dmitrij Lisak, Lars Schneider, Axel Methner
Androgen-induced gene 1 (AIG1) is a transmembrane protein implicated with survival (its expression level was shown to correlate with the survival of patients suffering from hepatocellular carcinoma) and Ca(2+) signaling (over-expression of AIG1 increased transcription mediated by the Ca(2+)-dependent nuclear factor of activated T cells). We aimed to shed light on this less-studied protein and investigated its tissue expression, genomic organization, intracellular localization and membrane topology as well as its effects on cell death susceptibility and the Ca(2+) content of the endoplasmic reticulum...
July 15, 2016: Gene
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