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Norah K Alajaji, David Bardwell, Matthew Finkelman, Ala Ali
OBJECTIVES: To evaluate the marginal and internal adaptation of CAD/CAM lithium-disilicate inlay restorations fabricated by two milling systems (Five and Three-axis), and a traditional heat-press technique. METHODS: Fifteen premolar teeth with an MOD cavity preparation were fabricated. Lithium-disilicate inlay restorations were obtained by three fabrication techniques and fitted to their dies (n = 15/gp) as follows: Group-1, three-axis milling system, Group-2, five-axis milling system, Group-3, conventional heat-press technique...
September 29, 2016: Journal of Esthetic and Restorative Dentistry
Xinbo Zhang, Anna Dastiridou, Brian A Francis, Ou Tan, Rohit Varma, David S Greenfield, Joel S Schuman, Mitra Sehi, Vikas Chopra, David Huang
PURPOSE: To identify baseline structural parameters that predict the progression of visual field (VF) loss in patients with open angle glaucoma. DESIGN: Multicenter cohort study. METHODS: Participants from Advanced Imaging for Glaucoma (AIG) study were enrolled and followed-up. VF progression is defined as either a confirmed progression event on Humphrey Progression Analysis or a significant (p<0.05) negative slope for VF index (VFI). Fourier-domain optical coherence tomography (FD-OCT) was used to measure optic disc, peripapillary retinal nerve fiber layer (NFL) and macular ganglion cell complex (GCC) thickness parameters...
September 17, 2016: American Journal of Ophthalmology
Behroz Atashbar, Naser Agh, Ramin Manaffar, Gilbert Van Stappen, Ali Mohamadyari, Johan Mertens, Lynda Beladjal
Branchinecta orientalis is a fairy shrimp endemic to the Palearctic region, from Mongolia to Spain. The patchy nature of its habitat is thought to result in a high degree of subdivision among populations, potentially promoting speciation. We combined morphometric characteristics with molecular phylogeny of cytochrome c oxidase I (COI) to test whether B. orientalis could be a species complex and whether there is any correlation between the genetic variation, morphometric characteristics and geographical variables...
2016: Zootaxa
Jessica Harakal, Claudia Rival, Hui Qiao, Kenneth S Tung
Pernicious anemia and gastric carcinoma are serious sequelae of autoimmune gastritis (AIG). Our study indicates that in adult C57BL/6-DEREG mice expressing a transgenic diphtheria toxin receptor under the Foxp3 promoter, transient regulatory T cell (Treg) depletion results in long-lasting AIG associated with both H(+)K(+)ATPase and intrinsic factor autoantibody responses. Although functional Tregs emerge over time during AIG occurrence, the effector T cells rapidly become less susceptible to Treg-mediated suppression...
July 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
Marybeth Anderson, Raoud Marayati, Richard Moffitt, Jen Jen Yeh
Pancreatic ductal adenocarcinoma (PDAC) is a KRAS-driven cancer with a high incidence of metastasis and an overall poor prognosis. Previous work in a genetically engineered mouse model of PDAC showed glucose metabolism to be important for maintaining tumor growth. Multiple glycolytic enzymes, including hexokinase 2 (HK2), were upregulated in primary PDAC patient tumors, supporting a role for glycolysis in promoting human disease. HK2 was most highly expressed in PDAC metastases, suggesting a link between HK2 and aggressive tumor biology...
June 1, 2016: Oncotarget
Nadine Nickel, Astrid Cleven, Vitalij Enders, Dmitrij Lisak, Lars Schneider, Axel Methner
Androgen-induced gene 1 (AIG1) is a transmembrane protein implicated with survival (its expression level was shown to correlate with the survival of patients suffering from hepatocellular carcinoma) and Ca(2+) signaling (over-expression of AIG1 increased transcription mediated by the Ca(2+)-dependent nuclear factor of activated T cells). We aimed to shed light on this less-studied protein and investigated its tissue expression, genomic organization, intracellular localization and membrane topology as well as its effects on cell death susceptibility and the Ca(2+) content of the endoplasmic reticulum...
July 15, 2016: Gene
Yuya Taguchi, Daisuke Fujinami, Daisuke Kohda
The glycosylation of asparagine residues is the predominant protein modification in all three domains of life. An oligosaccharide chain is preassembled on a lipid-phospho carrier and transferred onto asparagine residues by the action of a membrane-bound enzyme, oligosaccharyltransferase. The oligosaccharide donor for the oligosaccharyl transfer reaction is dolichol-diphosphate-oligosaccharide in Eukaryota and polyprenol-diphosphate-oligosaccharide in Eubacteria. The donor in some archaeal species was reportedly dolichol-monophosphate-oligosaccharide...
May 20, 2016: Journal of Biological Chemistry
Debra Pugh, Andre De Champlain, Mark Gierl, Hollis Lai, Claire Touchie
With the recent interest in competency-based education, educators are being challenged to develop more assessment opportunities. As such, there is increased demand for exam content development, which can be a very labor-intense process. An innovative solution to this challenge has been the use of automatic item generation (AIG) to develop multiple-choice questions (MCQs). In AIG, computer technology is used to generate test items from cognitive models (i.e. representations of the knowledge and skills that are required to solve a problem)...
August 2016: Medical Teacher
Xu Han, Sufang Hou, Aige Yang
BACKGROUND: Diabetes mellitus a common metabolic disorder with hyperglycemia, is caused by the interaction of genetic and environmental factors. Approximately 12~20% of diabetic patients have risk of colorectal cancer. Recent studies revealed that the insulin-like growth factor system (IGFs) plays an important role in tumor occurrence. This study thus investigated the relationship between IGFs-related proteins in diabetic patients and the incidence of colorectal carcinoma. MATERIAL/METHODS: A retrospective study was performed in a total of 206 individuals, including 85 diagnosed with diabetes...
2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Xinbo Zhang, Brian A Francis, Anna Dastiridou, Vikas Chopra, Ou Tan, Rohit Varma, David S Greenfield, Joel S Schuman, David Huang
PURPOSE: We studied the effects of age and intraocular pressure (IOP) on retinal nerve fiber layer (NFL) and macular ganglion cell complex (GCC) thickness in normal eyes. METHODS: Data from subjects from the multicenter Advanced Imaging for Glaucoma Study (AIGS) were analyzed. The data included yearly visits from the normal subjects in the AIGS study. Fourier-domain optical coherence tomography (FD-OCT) was used to measure retinal NFL and macular GCC on each visit...
March 2016: Translational Vision Science & Technology
Hollis Lai, Mark J Gierl, B Ellen Byrne, Andrew I Spielman, David M Waldschmidt
Test items created for dentistry examinations are often individually written by content experts. This approach to item development is expensive because it requires the time and effort of many content experts but yields relatively few items. The aim of this study was to describe and illustrate how items can be generated using a systematic approach. Automatic item generation (AIG) is an alternative method that allows a small number of content experts to produce large numbers of items by integrating their domain expertise with computer technology...
March 2016: Journal of Dental Education
Hollis Lai, Mark J Gierl, Claire Touchie, Debra Pugh, André-Philippe Boulais, André De Champlain
UNLABELLED: CONSTRUCT: Automatic item generation (AIG) is an alternative method for producing large numbers of test items that integrate cognitive modeling with computer technology to systematically generate multiple-choice questions (MCQs). The purpose of our study is to describe and validate a method of generating plausible but incorrect distractors. Initial applications of AIG demonstrated its effectiveness in producing test items. However, expert review of the initial items identified a key limitation where the generation of implausible incorrect options, or distractors, might limit the applicability of items in real testing situations...
2016: Teaching and Learning in Medicine
Tsubasa Saito, Satoru Suenaga, Masato Fujii, Yoshihiro Kushida, Yusuke Kawauchi, Kenji Suzuki, Maki Touma, Masamichi Hosono
The autoantibodies (auto-Abs) that are a hallmark of neonatally thymectomized (NTx) mice with autoimmune gastritis (AIG) have been poorly explored. We investigated their immune significance using B cell-deficient (B(-)) mice and found that B(-) mice are totally resistant to AIG but become susceptible to AIG after receiving bone marrow cells from B(+) mice. This susceptibility is most likely caused by the production of auto-Abs by B cells because B(-) pups also became susceptible to AIG when nourished by an AIG dam producing auto-Abs of the IgG class during the suckling period...
February 2016: Cellular Immunology
Marino Venerito, Mariya Varbanova, Friedrich-Wilhelm Röhl, Dirk Reinhold, Katrin Frauenschläger, Doerthe Jechorek, Jochen Weigt, Alexander Link, Peter Malfertheiner
AIM: To assess characteristics of oxyntic gastric atrophy (OGA) in autoimmune gastritis (AIG) compared with OGA as a consequence of Helicobacter pylori infection. METHODS: Patients undergoing oesophagogastroduodenoscopy from July 2011 to October 2014 were prospectively included (N=452). Gastric biopsies were obtained for histology and H. pylori testing. Serum gastrin-17 (G17), pepsinogen (PG) I, PGII and antibodies against H. pylori and cytotoxin-associated gene A protein were determined in all patients...
August 2016: Journal of Clinical Pathology
Çağdaş Kalkan, Irfan Soykan, Çiğdem Soydal, Elgin Özkan, Emra Kalkan
BACKGROUND AND AIM: Symptoms of patients with autoimmune gastritis are not specific, and some patients may present symptoms suggestive of delayed gastric emptying. This study aims to investigate whether any delay in gastric emptying of solid food exists in patients with autoimmune gastritis and, if so, to identify the factors that might affect delayed gastric emptying. METHODS: A total of 165 patients (106 women) diagnosed as having autoimmune gastritis were analyzed by means of a gastric emptying test...
June 2016: Digestive Diseases and Sciences
Matteo Fassan, Deborah Saraggi, Laura Balsamo, Luciano Cascione, Carlo Castoro, Irene Coati, Marina De Bernard, Fabio Farinati, Vincenza Guzzardo, Nicola Valeri, Carlo Federico Zambon, Massimo Rugge
Aberrant let-7c microRNA (miRNA) expression has been observed in Helicobacter pylori-related gastric cancer (GC) but fragmentary information is available on the let-7c dysregulation occurring with each phenotypic change involved in gastric carcinogenesis. Let-7c expression was assessed (qRT-PCR) in a series of 175 gastric biopsy samples representative of the whole spectrum of phenotypic changes involved in H. pylori-related gastric oncogenesis including: i) normal gastric mucosa, as obtained from dyspeptic controls (40 biopsy samples); ii) non-atrophic gastritis (40 samples); iii) atrophic-metaplastic gastritis (35 samples); iv) intra-epithelial neoplasia (30 samples); v) GC (30 samples)...
January 26, 2016: Oncotarget
Yuan Lin, Jon Mallen-St Clair, Jie Luo, Sherven Sharma, Steven Dubinett, Maie St John
OBJECTIVES: To investigate the role of p53 in NF-κB mediated epithelial-to-mesenchymal (EMT) in head and neck squamous cell carcinoma (HNSCC). MATERIALS AND METHODS: We utilized HNSCC and normal oral epithelial cell lines as our model system. We used a lentiviral shRNA system to silence the expression of p65 and p53 in these cell lines. Mutant and wild-type (WT) p53 background genotypes were analyzed. The expression of epithelial and mesenchymal markers was determined using western blotting and quantitative PCR assays...
October 2015: Oral Oncology
Yukina Hirata, Hirotsugu Yamada, Kenya Kusunose, Takashi Iwase, Susumu Nishio, Shuji Hayashi, Mika Bando, Rie Amano, Koji Yamaguchi, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata
BACKGROUND: The relationship between epicardial adipose tissue (EAT) and coronary artery disease (CAD) has recently attracted a great deal of attention in the medical community. The objective of this study was to determine whether measuring EAT thickness in the anterior interventricular groove (AIG) using echocardiography is feasible and whether this index can be a marker of CAD. METHODS: A total of 311 patients (mean age, 67 ± 11 years; 208 men) who underwent coronary angiography between December 2011 and December 2013 were prospectively enrolled...
October 2015: Journal of the American Society of Echocardiography
William F McCool, Mamie Guidera, Ellie Griffinger, Dulcy Sacan
INTRODUCTION: The risk of litigation remains of concern to midwives, their practice partners, employers, and malpractice insurance providers. Closed claims analysis is a method of examining risk patterns and behaviors in lawsuits, including those involving health care practices. The purpose of this investigation was to evaluate claims brought against midwives, with the intent of developing strategies to decrease the incidence of litigation. METHODS: Data were collected in joint meetings with members of the American College of Nurse-Midwives (ACNM); the American Association of Birth Centers; the American International Group (AIG), a major malpractice insurer for certified nurse-midwives/certified midwives (CNMs/CMs); and Contemporary Insurance Services, an independent insurance agency that has worked with AIG to facilitate the writing of malpractice insurance policies for CNMs/CMs...
July 2015: Journal of Midwifery & Women's Health
M Rasouli, H Shokri-Afra, A Ostovar-Ravari
OBJECTIVE: The glycogen is extracted routinely from animal tissues with cold perchloric acid (PCA). Acid soluble glycogen (ASG) is extracted, while the insoluble fraction (AIG) is liberated using hot alkaline. The current study was performed to separate and measure ASG, AIG and total glycogen in the same sample simultaneously. MATERIALS AND METHODS: The protocol has the four phases of tissue digestion, extraction, separation of fractions and measurement. The liver tissue was weighed and digested with four volumes of 30% KOH and heated in boiling water bath for 10 min...
May 2015: European Review for Medical and Pharmacological Sciences
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