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https://www.readbyqxmd.com/read/28213200/validation-of-a-quantitative-method-to-measure-neural-respiratory-drive-in-children-during-sleep
#1
Sandra Ya-Chu Chuang, Arthur Teng, Jane Elizabeth Butler, Simon Charles Gandevia, Hiran Selvadurai, Adam Jaffe
AIMS: Quantitatively measure and validate analysis of neural respiratory drive (NRD) using a commercial polysomnography system in children during sleep. METHOD: Surface electromyogram of the diaphragm (sEMGdi) recorded from primary snoring children were analysed. A subset was re-analysed to assess intra- and inter-investigator reproducibility. Effects of different band pass filter settings (20-100Hz vs 10-1000Hz) on sEMGdi amplitude were evaluated. RESULTS: Mean sEMGdi from 45 children aged 4...
February 14, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28212857/temporal-modulations-in-speech-and-music
#2
REVIEW
Nai Ding, Aniruddh D Patel, Lin Chen, Henry Butler, Cheng Luo, David Poeppel
Speech and music have structured rhythms. Here we discuss a major acoustic correlate of spoken and musical rhythms, the slow (0.25- 32Hz) temporal modulations in sound intensity and compare the modulation properties of speech and music. We analyze these modulations using over 25hours of speech and over 39hours of recordings of Western music. We show that the speech modulation spectrum is highly consistent across 9 languages (including languages with typologically different rhythmic characteristics). A different, but similarly consistent modulation spectrum is observed for music, including classical music played by single instruments of different types, symphonic, jazz, and rock...
February 14, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28209642/orbital-infarction-with-haematoma-in-sickle-cell-disease
#3
Matthew R Edmunds, Lucilla Butler
No abstract text is available yet for this article.
February 16, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28209282/intimate-partner-violence-screening-in-the-veterans-health-administration-demographic-and-military-service-characteristics
#4
Melissa E Dichter, Terri N Haywood, Anneliese E Butler, Scarlett L Bellamy, Katherine M Iverson
INTRODUCTION: Intimate partner violence (IPV) includes psychological, physical, or sexual aggression by a current or former intimate partner and is associated with a wide range of health and social impacts, especially for women. Women veterans may be at increased risk for experiencing IPV, and some Veterans Health Administration (VHA) facilities have initiated routine screening of female patients for past-year IPV. This study presents the first examination of clinical IPV screening responses recorded from female VHA patients across 13 facilities nationwide, and identifies associations with patient demographic and military service characteristics...
February 10, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28205584/a-postnatal-role-for-embryonic-myosin-revealed-by-myh3-mutations-that-alter-tgf%C3%AE-signaling-and-cause-autosomal-dominant-spondylocarpotarsal-synostosis
#5
Jennifer Zieba, Wenjuan Zhang, Jessica X Chong, Kimberly N Forlenza, Jorge H Martin, Kelly Heard, Dorothy K Grange, Merlin G Butler, Tjitske Kleefstra, Ralph S Lachman, Deborah Nickerson, Michael Regnier, Daniel H Cohn, Michael Bamshad, Deborah Krakow
Spondylocarpotarsal synostosis (SCT) is a skeletal disorder characterized by progressive vertebral, carpal and tarsal fusions, and mild short stature. The majority of affected individuals have an autosomal recessive form of SCT and are homozygous or compound heterozygous for nonsense mutations in the gene that encodes the cytoskeletal protein filamin B (FLNB), but a subset do not have FLNB mutations. Exome sequence analysis of three SCT patients negative for FLNB mutations identified an autosomal dominant form of the disease due to heterozygosity for missense or nonsense mutations in MYH3, which encodes embryonic myosin...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28203387/an-overview-of-available-drugs-for-management-of-opioid-abuse-during-pregnancy
#6
REVIEW
Jillian Laslo, Jon-Michael Brunner, Daniel Burns, Emily Butler, Autumn Cunningham, Ryan Killpack, Courtney Pyeritz, Kimberly Rinard, Jennifer Childers, Joseph Horzempa
The prevalence of opioid abuse in the United States has been steadily increasing over the last several years among many major demographics, including pregnant women. Rise in prenatal opioid abuse has resulted in subsequent escalation of neonatal abstinence syndrome incidence, prompting the US Congress to pass the Protecting Our Infants Act of 2015. This act specifically calls for a critical review of current treatment options for prenatal opioid abuse which may ultimately lead to the development of better therapies and a decreased incidence of neonatal abstinence syndrome...
2017: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/28202780/erratum-for-the-report-molecular-remission-of-infant-b-all-after-infusion-of-universal-talen-gene-edited-car-t-cells-by-w-qasim-h-zhan-s-samarasinghe-s-adams-p-amrolia-s-stafford-k-butler-c-rivat-g-wright-k-somana-s-ghorashian-d-pinner-g-ahsan-k-gilmour-g-lucchini
#7
https://www.readbyqxmd.com/read/28202350/chronic-social-instability-increases-anxiety-like-behavior-and-ethanol-preference-in-male-long-evans-rats
#8
Alyssa R Roeckner, Alexandra Bowling, Tracy R Butler
Chronic stress during adolescence is related to increased prevalence of anxiety disorders and alcohol use disorders in humans. This phenotype has been consistently recapitulated in animal models with male subjects, but models using female subjects are fewer. The aim of these studies was to test the hypothesis that chronic social instability (CSI) during adolescence engenders increased anxiety-like behavior, increased corticosterone, and greater ethanol intake and/or preference than control groups in male and female rats...
February 13, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28199403/comparison-of-microbiological-diagnosis-of-urinary-tract-infection-in-young-children-by-routine-health-service-laboratories-and-a-research-laboratory-diagnostic-cohort-study
#9
Kate Birnie, Alastair D Hay, Mandy Wootton, Robin Howe, Alasdair MacGowan, Penny Whiting, Michael Lawton, Brendan Delaney, Harriet Downing, Jan Dudley, William Hollingworth, Catherine Lisles, Paul Little, Kathryn O'Brien, Timothy Pickles, Kate Rumsby, Emma Thomas-Jones, Judith Van der Voort, Cherry-Ann Waldron, Kim Harman, Kerenza Hood, Christopher C Butler, Jonathan A C Sterne
OBJECTIVES: To compare the validity of diagnosis of urinary tract infection (UTI) through urine culture between samples processed in routine health service laboratories and those processed in a research laboratory. POPULATION AND METHODS: We conducted a prospective diagnostic cohort study in 4808 acutely ill children aged <5 years attending UK primary health care. UTI, defined as pure/predominant growth ≥105 CFU/mL of a uropathogen (the reference standard), was diagnosed at routine health service laboratories and a central research laboratory by culture of urine samples...
2017: PloS One
https://www.readbyqxmd.com/read/28199170/antibody-repertoire-development-in-swine
#10
J E Butler, Nancy Wertz, Marek Sinkora
We describe the domestication of the species, explore its value to agriculture and bioscience, and compare its immunoglobulin (Ig) genes to those of other vertebrates. For encyclopedic information, we cite earlier reviews and chapters. We provide current gene maps for the heavy and light chain loci and describe their polygeny and polymorphy. B-cell and antibody repertoire development is a major focus, and we present findings that challenge several mouse-centric paradigms. We focus special attention on the role of ileal Peyer's patches, the largest secondary lymphoid tissues in newborn piglets and a feature of all artiodactyls...
February 8, 2017: Annual Review of Animal Biosciences
https://www.readbyqxmd.com/read/28199149/a-genetic-method-to-evaluate-the-prevalence-of-unique-dna-profiles-between-sequential-ground-beef-batches
#11
G Peters, B Cleveland, J Higgins, F Butler, C Meghen
The delineation of ground beef batches has implications for the management of product disposition policies in the event of Shiga toxin-producing Escherichia coli contamination. Analysis of individual contributor animal-specific DNA profiles can provide valuable empirical data for understanding the dynamics of ground meat production processes and can act as a surrogate for cross-contamination. A genetic method was developed for characterizing the source raw material flow and carryover between discrete batches of ground beef in a large-scale commercial beef grinding operation...
February 15, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28196947/cohort-profile-the-welsh-geriatric-registrar-led-research-network-wegen-rationale-design-and-description
#12
Benjamin Jelley, Sara Long, John Butler, Jonathan Hewitt
PURPOSE: Medical trainees are required to undertake audit and quality improvement projects. They must also have an understanding of the principles of research and are encouraged to participate in research projects. However, the constraints of time, a lack of formal training and rotation between different training posts create barriers to audit cycle completion and pursuing research. This leads to trainees being reluctant to undertake research, facilitates poor quality research and risks incomplete audit...
February 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/28196695/impact-of-erg3-mutations-and-expression-of-ergosterol-genes-controlled-by-upc2-and-ndt80-in-candida-parapsilosis-azole-resistance
#13
Joana Branco, Mihaela Ola, Raquel M Silva, Elizangela Fonseca, Nuno C Gomes, Cláudia Martins-Cruz, Ana P Silva, Ana Silva-Dias, Cidália Pina-Vaz, Claire Erraught, Lorraine Brennan, Acácio Gonçalves Rodrigues, Geraldine Butler, Isabel M Miranda
OBJECTIVES: C. parapsilosis is a health care related fungal pathogen particularly common among immunocompromised patients. Our understanding of antifungal resistance mechanisms in C. parapsilosis remains very limited. We previously described an azole-resistant strain of C. parapsilosis (BC014RPSC), obtained following exposure in vitro to posaconazole. Resistance was associated with overexpression of ergosterol biosynthetic genes (ERG genes), together with the transcription factors UPC2 (CPAR2-207280) and NDT80 (CPAR2-213640)...
February 11, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28196547/validation-of-a-mathematical-model-of-the-bovine-estrous-cycle-for-cows-with-different-estrous-cycle-characteristics
#14
H M T Boer, S T Butler, C Stötzel, M F W Te Pas, R F Veerkamp, H Woelders
A recently developed mechanistic mathematical model of the bovine estrous cycle was parameterized to fit empirical data sets collected during one estrous cycle of 31 individual cows, with the main objective to further validate the model. The a priori criteria for validation were (1) the resulting model can simulate the measured data correctly (i.e. goodness of fit), and (2) this is achieved without needing extreme, probably non-physiological parameter values. We used a least squares optimization procedure to identify parameter configurations for the mathematical model to fit the empirical in vivo measurements of follicle and corpus luteum sizes, and the plasma concentrations of progesterone, estradiol, FSH and LH for each cow...
February 15, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28195944/regulatory-advocacy-update-asps-comments-in-response-to-the-fda-draft-guidance-documents-on-human-cell-and-tissue-products
#15
J Peter Rubin, Richard A D'Amico, Ricardo Rodriguez, Sydney R Coleman, Paul Cederna, Scot Glasberg, Michael Neumeister, David H Song, Charles Butler, Keith M Hume
The Food and Drug Administration (FDA) released draft guidance documents on Human Cells, Tissues, and Cellular and Tissue-Based Products (HCT/P) Regulations. These proposed guidance documents can impact the practice of plastic surgery in the area of tissue grafting procedures. This article describes the relevant issues in these draft guidance documents, and presents the comments provided to the FDA by the American Society of Plastic Surgeons (ASPS).
February 9, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28195568/military-deployment-correlates-with-smaller-prefrontal-gray-matter-volume-and-psychological-symptoms-in-a-subclinical-population
#16
O Butler, J Adolf, T Gleich, G Willmund, P Zimmermann, U Lindenberger, J Gallinat, S Kühn
Research investigating the effects of trauma exposure on brain structure and function in adults has mainly focused on post-traumatic stress disorder (PTSD), whereas trauma-exposed individuals without a clinical diagnoses often serve as controls. However, this assumes a dichotomy between clinical and subclinical populations that may not be supported at the neural level. In the current study we investigate whether the effects of repeated or long-term stress exposure on brain structure in a subclinical sample are similar to previous PTSD neuroimaging findings...
February 14, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28194591/complications-in-diep-flap-breast-reconstruction-after-mastectomy-for-breast-cancer-a-prospective-cohort-study-comparing-unilateral-and-bilateral-reconstructions
#17
EDITORIAL
Mark V Schaverien, Charles E Butler
No abstract text is available yet for this article.
February 13, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28192419/seq-well-portable-low-cost-rna-sequencing-of-single-cells-at-high-throughput
#18
Todd M Gierahn, Marc H Wadsworth, Travis K Hughes, Bryan D Bryson, Andrew Butler, Rahul Satija, Sarah Fortune, J Christopher Love, Alex K Shalek
Single-cell RNA-seq can precisely resolve cellular states, but applying this method to low-input samples is challenging. Here, we present Seq-Well, a portable, low-cost platform for massively parallel single-cell RNA-seq. Barcoded mRNA capture beads and single cells are sealed in an array of subnanoliter wells using a semipermeable membrane, enabling efficient cell lysis and transcript capture. We use Seq-Well to profile thousands of primary human macrophages exposed to Mycobacterium tuberculosis.
February 13, 2017: Nature Methods
https://www.readbyqxmd.com/read/28192216/a-low-redox-potential-affects-monoclonal-antibody-assembly-and-glycosylation-in-cell-culture
#19
Benjamin Dionne, Neha Mishra, Michael Butler
Glycosylation and intracellular assembly of monoclonal antibodies (MAbs) is important for glycan profile consistency. To better understand how these factors may be influenced by a lower redox potential, an IgG1-producing NS0 cell line was grown in the presence of varying concentrations of dithiothreitol (DTT). Cultures were monitored for growth and culture redox potential (CRP) with glycan heterogeneity determined using a HILIC-HPLC method. Macroheterogeneity was unchanged in all conditions whereas the Galactosylation Index (GI) decreased by as much as 50% in cultures with lower CRP or higher dithiothreitol levels...
February 11, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28190947/acceptability-of-a-positive-parenting-programme-on-a-mother-and-baby-unit-q-methodology-with-staff
#20
Hannah Butler-Coyne, Dougal Hare, Samantha Walker, Angelika Wieck, Anja Wittkowski
The Baby Triple P Positive Parenting Programme, a new addition to the established Triple P programmes, is currently being considered for a trial in a Mother and Baby Unit with the aim of exploring its benefits to mothers presenting with severe mental illness. The aim of the current study was to investigate staff views of the acceptability and feasibility of a parenting programme such as the Baby Triple P Positive Parenting Programme in a Mother and Baby Unit. Q-methodology, using an 88-item Q-sort, was employed to explore the opinions of 16 staff working in a Mother and Baby Unit in the North West of England...
2017: Journal of Child and Family Studies
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