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https://www.readbyqxmd.com/read/28732307/a-multisite-audit-to-assess-how-women-with-complex-social-factors-access-and-engage-with-maternity-services
#1
Hannah Rayment-Jones, Eleanor Butler, Chelsie Miller, Christine Nay, Jennifer O'Dowd
OBJECTIVE: to audit women with socially complex lives' documented access to and engagement with antenatal care provided by three inner city, UK maternity services in relation to birth and neonatal outcomes, and referral processes. BACKGROUND: women living socially complex lives, including young mothers, recently arrived immigrants, non-English speaking, and those experiencing domestic violence, poor mental health, drug and alcohol abuse, and poverty experience high rates of morbidity, mortality and poor birth outcomes...
June 27, 2017: Midwifery
https://www.readbyqxmd.com/read/28731869/individual-and-population-level-impacts-of-traumatic-brain-injury-and-maternal-characteristics-on-subsequent-offending-behavior
#2
Handan Wand, Melanie Simpson, Eva Malacova, Peter W Schofield, David B Preen, Robyn Tate, Tony Butler
OBJECTIVE: To evaluate the individual- and population-level impact of a combination of factors, including traumatic brain injury (TBI) and certain maternal characteristics, on subsequent criminal conviction. DESIGN AND PARTICIPANTS: A retrospective record linkage study involving a cohort of 30 599 individuals born between 1980 and 1985, with ratio of 1 (with TBI): 3 (no TBI), matched by sex and the year of birth. METHODS AND PROCEDURES: Cox proportional hazard regression models and population attributable risk percentages (PAR%) were used to assess the contribution of TBI and other risk factors on subsequent criminal convictions...
July 20, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28729190/systematic-review-of-the-use-of-3-dimensional-printing-in-surgical-teaching-and-assessment
#3
Benjamin Langridge, Sheikh Momin, Ben Coumbe, Evelina Woin, Michelle Griffin, Peter Butler
OBJECTIVE: The use of 3-dimensional (3D) printing in medicine has rapidly expanded in recent years as the technology has developed. The potential uses of 3D printing are manifold. This article provides a systematic review of the uses of 3D printing within surgical training and assessment. METHODS: A structured literature search of the major literature databases was performed in adherence to PRISMA guidelines. Articles that met predefined inclusion and exclusion criteria were appraised with respect to the key objectives of the review and sources of bias were analysed...
July 17, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28729055/novel-1-2-dihydroquinazolin-2-ones-design-synthesis-and-biological-evaluation-against-trypanosoma-brucei
#4
ThanhTruc Pham, Madeline Walden, Christopher Butler, Rosario Diaz-Gonzalez, Guiomar Pérez-Moreno, Gloria Ceballos-Pérez, Veronica Gomez-Pérez, Raquel García-Hernández, Henry Zecca, Emma Krakoff, Brian Kopec, Ogar Ichire, Caden Mackenzie, Marika Pitot, Luis Miguel Ruiz, Francisco Gamarro, Dolores González-Pacanowska, Miguel Navarro, Amy B Dounay
In 2014, a published report of the high-throughput screen of>42,000 kinase inhibitors from GlaxoSmithKline against T. brucei identified 797 potent and selective hits. From this rich data set, we selected NEU-0001101 (1) for hit-to-lead optimization. Through our preliminary compound synthesis and SAR studies, we have confirmed the previously reported activity of 1 in a T. brucei cell proliferation assay and have identified alternative groups to replace the pyridyl ring in 1. Pyrazole 24 achieves improvements in both potency and lipophilicity relative to 1, while also showing good in vitro metabolic stability...
July 11, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28727838/prevalence-and-factors-associated-with-recent-intimate-partner-violence-and-relationships-between-disability-and-depression-in-post-partum-women-in-one-clinic-in-ethekwini-municipality-south-africa
#5
Andrew Gibbs, Bradley Carpenter, Tamaryn Crankshaw, Jill Hannass-Hancock, Jennifer Smit, Mark Tomlinson, Lisa Butler
Intimate partner violence (IPV) experienced by pregnant and post-partum women has negative health effects for women, as well as the foetus, and the new-born child. In this study we sought to assess the prevalence and factors associated with recent IPV amongst post-partum women in one clinic in eThekwini Municipality, South Africa, and explore the relationship between IPV, depression and functional limitations/disabilities. Past 12 month IPV-victimisation was 10.55%. Logistic regression modelled relationships between IPV, functional limitations, depressive symptoms, socio-economic measures, and sexual relationship power...
2017: PloS One
https://www.readbyqxmd.com/read/28726845/climate-scientists-flock-to-france-s-call
#6
Declan Butler
No abstract text is available yet for this article.
July 18, 2017: Nature
https://www.readbyqxmd.com/read/28726415/enhanced-diffusion-of-passive-tracers-in-active-enzyme-solutions
#7
Xi Zhao, Krishna Kanti Dey, Selva Jeganathan, Peter J Butler, Ubaldo M Córdova-Figueroa, Ayusman Sen
Colloidal suspensions containing microscopic swimmers have been the focus of recent studies aimed at understanding the principles of energy transfer in fluidic media at low Reynolds number conditions. Going down in scale, active enzymes have been shown to be force-generating, non-equilibrium systems, thus offering opportunity to examine energy transfer at the ultralow Reynolds number regime. By monitoring the change of diffusion of inert tracers dispersed in active enzyme solutions, we demonstrate that the nature of energy transfer in these systems is similar to that reported for larger microscopic active systems, despite the large differences in scale, modes of energy transduction and propulsion...
July 20, 2017: Nano Letters
https://www.readbyqxmd.com/read/28724953/antimicrobial-efficacy-and-synergy-of-metal-ions-against-enterococcus-faecium-klebsiella-pneumoniae-and-acinetobacter-baumannii-in-planktonic-and-biofilm-phenotypes
#8
Misha Y Vaidya, Andrew J McBain, Jonathan A Butler, Craig E Banks, Kathryn A Whitehead
The effects of metal ion solutions (silver, copper, platinum, gold and palladium) were determined individually and in combination against Enterococcus faecium, Acinetobacter baumannii and Klebsiella pneumoniae. Platinum, gold and palladium showed the greatest antimicrobial efficacy in zone of inhibition (ZoI) assays. When tested in combinations using ZoI assays, gold/platinum, gold/palladium and platinum/palladium were indicative of synergy. Microbial inhibitory concentration demonstrated platinum and gold against Enterococcus faecium, platinum against Klebsiella pneumoniae and platinum and silver against Acinetobacter baumannii were optimal...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28720516/ahrq-series-on-complex-intervention-systematic-reviews-paper-6-prisma-ci-extension-statement-checklist
#9
Jeanne-Marie Guise, Mary E Butler, Christine Chang, Meera Viswanathan, Terri Pigott, Peter Tugwell
BACKGROUND: Complex interventions are widely used in health systems, public health, education, and communities and are increasingly the subject of systematic reviews. Oversimplification and inconsistencies in reporting about complex interventions can limit the usability of review findings. RATIONALE: While guidance exists to ensure that reports of individual studies and systematic reviews adhere to accepted scientific standards, their design-specific focus leaves important reporting gaps relative to complex interventions in health care...
June 28, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28720515/ahrq-series-on-complex-intervention-systematic-reviews-paper-4-selecting-analytic-approaches
#10
Meera Viswanathan, Melissa L McPheeters, M Hassan Murad, Mary E Butler, Emily E Beth Devine, Michele P Dyson, Jeanne-Marie Guise, Leila C Kahwati, Jeremy N V Miles, Sally C Morton
BACKGROUND: Systematic reviews of complex interventions can vary widely in purpose, data availability and heterogeneity, and stakeholder expectations. RATIONALE: This article addresses the uncertainty that systematic reviewers face in selecting methods for reviews of complex interventions. Specifically, it lays out parameters for systematic reviewers to consider when selecting analytic approaches that best answer the questions at hand, and suggests analytic techniques that may be appropriate in different circumstances...
June 29, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28720514/ahrq-series-on-complex-intervention-systematic-reviews-paper-2-defining-complexity-formulating-scope-and-questions
#11
Michael P Kelly, Jane Noyes, Robert L Kane, Christine Chang, Stacey Uhl, Karen A Robinson, Stacey Springs, Mary E Butler, Jeanne-Marie Guise
BACKGROUND: The early stages of a systematic review set the scope and expectations. This can be particularly challenging for complex interventions given their multi-dimensional and dynamic nature. RATIONALE: This paper builds on concepts introduced in Paper 1 of this series. It describes the methodological, practical and philosophical challenges and potential approaches for formulating the questions and scope of systematic reviews of complex interventions. Further it discusses the use of theory to help organize reviews of complex interventions...
June 29, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28720513/ahrq-series-on-complex-intervention-systematic-reviews-paper-7-prisma-ci-elaboration-explanation
#12
Jeanne-Marie Guise, Mary Butler, Christine Chang, Meera Viswanathan, Terri Pigott, Peter Tugwell
BACKGROUND: Complex interventions are widely used in health care, public health, education, criminology, social work, business, and welfare. They have increasingly become the subject of systematic reviews and are challenging to effectively report. The Complex Interventions Methods Workgroup developed an extension to the Preferred Reporting Items for Systematic Reviews and Meta-analyses for Complex Interventions called PRISMA-CI. RATIONALE: Following the EQUATOR Network guidance for PRISMA extensions, this Explanation and Elaboration document accompanies the PRISMA-CI checklist to promote consistency in reporting of systematic reviews of complex interventions...
June 30, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28720511/ahrq-series-on-complex-intervention-systematic-reviews-paper-1-an-introduction-to-a-series-of-papers-that-provide-guidance-and-tools-for-reviews-of-complex-interventions
#13
Jeanne-Marie Guise, Christine Chang, Mary E Butler, Meera Viswanathan, Peter Tugwell
No abstract text is available yet for this article.
June 27, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28720510/ahrq-series-on-complex-intervention-systematic-reviews-paper-3-adapting-frameworks-to-develop-protocols
#14
Mary Butler, Richard A Epstein, Annette Totten, Evelyn P Whitlock, Mohammed T Ansari, Laura J Damschroder, Ethan Balk, Eric B Bass, Nancy D Berkman, Susanne Hempel, Suchitra Iyer, Karen Schoelles, Jeanne-Marie Guise
BACKGROUND: Once a proposed topic has been identified for a systematic review and has undergone a question formulation stage, a protocol must be developed that specifies the scope and research questions in detail and outlines the methodology for conducting the systematic review. RATIONALE: Framework modifications are often needed to accommodate increased complexity. We describe and give examples of adaptations as well as alternatives to traditional analytic frameworks...
June 27, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28719549/long-term-follow-up-of-neonatal-brachial-plexopathy-psychological-and-physical-function-in-adolescents-and-young-adults
#15
Lesley Butler, Janith Mills, Heather M Richard, Russell Riddle, Marybeth Ezaki, Scott Oishi
PURPOSE: The prevalence of neonatal brachial plexus palsy (NBPP) has been increasing since the early 1980s. No known studies have examined long-term psychological health and quality of life (QOL) in young adults. The purpose of this study was to investigate the psychosocial and intellectual aspects of NBPP during adolescence into young adulthood. METHODS: A total of 31 patients were enrolled in the adolescent group (16 to 18 y) and 25 in the young adult group (23 to 28 y)...
July 17, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28718219/barriers-to-glaucoma-case-finding-as-perceived-by-optometrists-in-ireland
#16
Catriona Barrett, Colm O'Brien, John S Butler, James Loughman
BACKGROUND: This research was designed to provide an in-depth exploration of the perceptions of optometrists relating to the challenges of glaucoma case finding in the Irish health-care system. METHODS: A survey was developed, piloted and distributed for anonymous completion by optometrists registered to practise in Ireland. The survey included 10 five-level Likert items exploring potential barriers to glaucoma detection and a free-text box for participants to comment more broadly...
July 17, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28717723/cervical-abnormalities-in-south-african-women-living-with-hiv-with-high-screening-and-referral-rates
#17
Ingrid T Katz, Lisa M Butler, Tamaryn L Crankshaw, Alexi A Wright, Karen Bramhill, Dominick A Leone, Janet Giddy, Sean Mould
PURPOSE: To determine the prevalence of screening, cervical dysplasia, and malignancy on the basis of histologic diagnoses from colposcopy and large loop excision of the transformation zone among women living with HIV (WLWH) who attended an urban antiretroviral treatment (ART) clinic in KwaZulu-Natal, South Africa. MATERIALS AND METHODS: We performed a retrospective cohort study to examine a random sample of 462 WLWH during a 5-year period from 2004 to 2009. Women on ART for < 3 months were excluded...
December 2016: Journal of Global Oncology
https://www.readbyqxmd.com/read/28716862/gene-therapy-for-wiskott-aldrich-syndrome-in-a-severely-affected-adult
#18
Emma C Morris, Thomas Fox, Ronjon Chakraverty, Rita Tendeiro, Katie Snell, Christine Rivat, Sarah Grace, Kimberly Gilmour, Sarita Workman, Karen Buckland, Katie Butler, Ronnie Chee, Alan D Salama, Hazem Ibrahim, Havinder Hara, Cecile Duret, Fulvio Mavilio, Frances Male, Frederick D Bushman, Anne Galy, Siobhan O Burns, H Bobby Gaspar, Adrian J Thrasher
Until recently hematopoietic stem cell transplantation was the only curative option for Wiskott-Aldrich syndrome (WAS). The first attempts at gene therapy for WAS using a ϒ-retroviral vector improved immunological parameters substantially but were complicated by acute leukemia as a result of insertional mutagenesis in a high proportion of patients. More recently treatment of children with a state-of-the-art self-inactivating lentiviral vector (LV-w1.6 WASp) has resulted in significant clinical benefit without inducing selection of clones harbouring integrations near oncogenes...
July 17, 2017: Blood
https://www.readbyqxmd.com/read/28716569/recombinant-human-bone-morphogenetic-protein-2-versus-iliac-crest-bone-graft-in-anterior-cervical-discectomy-and-fusion-dysphagia-and-dysphonia-rates-in-the-early-postoperative-period-with-review-of-the-literature
#19
Brett D Riederman, Bennet A Butler, Cort D Lawton, Brett D Rosenthal, Earvin S Balderama, Avi J Bernstein
Recombinant human bone morphogenetic protein-2 (rhBMP-2) is a growth factor utilized to stimulate bone development in several clinical scenarios. Although the U.S. Food and Drug Administration approved this therapeutic modality for only two applications, it is frequently used off-label in anterior cervical discectomy and fusion (ACDF) procedures as an alternative to iliac crest bone graft (ICBG), the prior standard of care. This usage has been a source of controversy in the medical community due to evidence of increased rates of postoperative edema and dysphagia...
July 14, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28716549/emotional-labour-and-aboriginal-maternal-infant-care-workers-the-invisible-load
#20
R Kirkham, A Rumbold, E Hoon, D Stuart-Butler, V Moore
BACKGROUND: The term 'emotional labour' has been used to describe the competing demands on midwives to empathize with clients whilst maintaining a level of professional detachment. Previous research indicates that when individuals experience difficulty managing these emotions, burnout may result. Aboriginal health care workers often have roles with large emotional demands, as they are relied upon heavily to engage clients in care. However, the concept of emotional labour has received little attention in relation to this group...
July 14, 2017: Women and Birth: Journal of the Australian College of Midwives
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