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https://www.readbyqxmd.com/read/28636191/-fast-track-development-and-approval-process-for-heart-failure-therapeutics
#1
L Papadimitriou, J Butler
Heart failure (HF) is a global epidemic, with a high mortality and morbidity burden. In such diseases, earlier access to lifesaving therapeutic regimens is imperative, and could be accomplished by improving the drug development and approval process, without jeopardizing patient safety. The US Food and Drug Administration (FDA) has already established mechanisms facilitating the latter, but further guidance to enhance and expedite the process holds promise to further improve patient outcomes.
June 21, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28635998/heterogeneous-catalytic-hydrogenation-of-co2-by-metal-oxides-defect-engineering-perfecting-imperfection
#2
Jia Jia, Chenxi Qian, Yuchan Dong, Young Feng Li, Hong Wang, Mireille Ghoussoub, Keith T Butler, Aron Walsh, Geoffrey A Ozin
Metal oxides with their myriad compositions, structures and bonding exhibit an incredibly diverse range of properties. It is however the defects in metal oxides that endow them with a variety of functions and it is the ability to chemically tailor the type, population and distribution of defects on the surface and in the bulk of metal oxides that delivers utility in different applications. In this Tutorial Review, we discuss how metal oxides with designed defects can be synthesized and engineered, to enable heterogeneous catalytic hydrogenation of gaseous carbon dioxide to chemicals and fuels...
June 21, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28634008/aging-associated-modifications-of-collagen-affect-its-degradation-by-matrix-metalloproteinases
#3
Preety Panwar, Georgina S Butler, Andrew Jamroz, Pouya Azizi, Christopher M Overall, Dieter Brömme
The natural aging process and various pathologies correlate with alterations in the composition and the structural and mechanical integrity of the connective tissue. Collagens represent the most abundant matrix proteins and provide for the overall stiffness and resilience of tissues. The structural changes of collagens and their susceptibility to degradation are associated with skin wrinkling, bone and cartilage deterioration, as well as cardiovascular and respiratory malfunctions. Here, matrix metalloproteinases (MMPs) are major contributors to tissue remodeling and collagen degradation...
June 17, 2017: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/28632103/developmental-characteristics-of-disparate-bimanual-movement-skills-in-typically-developing-children
#4
Julian Rudisch, Jenny Butler, Hooshang Izadi, Deirdre Birtles, Dido Green
Mastery of many tasks in daily life requires role differentiated bimanual hand use with high spatiotemporal cooperation and minimal interference. The authors investigated developmental changes in the performance of a disparate bimanual movement task requiring sequenced movements. Age groups were attributed to changes in CNS structures critical for bimanual control such as the corpus callosum (CC) and the prefrontal cortex; young children (5-6 years old), older children (7-9 years old), and adolescents (10-16 years old)...
March 2, 2017: Journal of Motor Behavior
https://www.readbyqxmd.com/read/28632089/older-lesbians-receiving-home-care-formal-and-informal-dimensions-of-caregiving
#5
Sandra S Butler
Older lesbians face the triple jeopardy of ageism, sexism, and heterosexism, and their experiences are largely invisible. This qualitative, exploratory study examines the formal and informal caregiving experiences of 20 lesbians, 65 and older, who had utilized home care services due to acute illness or chronic disabilities. Half of those not partnered reported some level of isolation from support networks. Nearly all study participants eventually found home care workers with whom they were satisfied and even quite connected...
March 1, 2017: Journal of Women & Aging
https://www.readbyqxmd.com/read/28629224/-it-s-not-my-business-exploring-heteronormativity-in-young-people-s-discourses-about-lesbian-gay-bisexual-transgender-and-queer-issues-and-their-implications-for-youth-health-and-wellbeing
#6
Cara Ky Ng, Rebecca J Haines-Saah, Rodney E Knight, Jean A Shoveller, Joy L Johnson
In Canada, the issue of creating safe and inclusive school environments for lesbian, gay, bisexual, transgender, and queer students has been in the spotlight. Several researchers and advocates have pointed out the positive effects of lesbian, gay, bisexual, transgender, and queer-positive policy frameworks on the health and wellbeing of all young people. In this article, we take a critical approach to analyzing narrative findings from qualitative interviews conducted with youth in three communities in British Columbia, Canada: "the North," Vancouver, and Abbotsford...
June 1, 2017: Health (London)
https://www.readbyqxmd.com/read/28625374/change-the-management-of-patients-with-heart-failure-rationale-and-design-of-the-champ-hf-registry
#7
Adam D DeVore, Laine Thomas, Nancy M Albert, Javed Butler, Adrian F Hernandez, J Herbert Patterson, John A Spertus, Fredonia B Williams, Stuart J Turner, Wing W Chan, Carol I Duffy, Kevin McCague, Xiaojuan Mi, Gregg C Fonarow
Heart failure (HF) with reduced ejection fraction (HFrEF) is a common and costly condition that diminishes patients' health status and confers a poor prognosis. Despite the availability of multiple guideline-recommended pharmacologic and cardiac device therapies for patients with chronic HFrEF, outcomes remain suboptimal. Currently, there is limited insight into the rationale underlying clinical decisions by health care providers and patient factors that guide the use and intensity of outpatient HF treatments...
July 2017: American Heart Journal
https://www.readbyqxmd.com/read/28624484/progression-to-stage-d-heart-failure-among-outpatients-with-stage-c-heart-failure-and-reduced-ejection-fraction
#8
Andreas P Kalogeropoulos, Ayman Samman-Tahhan, Jeffrey S Hedley, Andrew A McCue, Jonathan B Bjork, David W Markham, Kunal N Bhatt, Vasiliki V Georgiopoulou, Andrew L Smith, Javed Butler
OBJECTIVES: This study sought to estimate the rate of progression to Stage D heart failure (HF) among outpatients with Stage C HF and to identify risk factors for progression. BACKGROUND: The pool of patients who may be candidates for advanced HF therapies is growing. METHODS: We estimated 3-year progression to clinically determined Stage D HF and competing mortality among 964 outpatients with Stage C heart failure with reduced ejection fraction (HFrEF), where ejection fraction is ≤40%...
June 14, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28622420/technical-note-comparison-of-megavoltage-dual-energy-and-single-energy-ct-based-%C3%AE-maps-for-a-4-channel-breast-coil-in-pet-mri
#9
John C Patrick, R Terry Thompson, Aaron So, John Butler, David Faul, Robert Z Stodilka, Slav Yartsev, Frank S Prato, Stewart Gaede
PURPOSE: The purpose of this study was to describe and evaluate methods for calculating a megavoltage computed tomography (MVCT) derived MR hardware attenuation map (μ-map) and dual-energy CT (DECT) for 511 keV photons. METHODS: Phantom measurements were acquired on a whole-body hybrid PET/MRI system, using a four-channel receive-only MR radiofrequency (RF) breast coil. Two acquisitions were performed: with the phantoms positioned in the four-channel RF breast coil, and without the breast coil...
June 16, 2017: Medical Physics
https://www.readbyqxmd.com/read/28621379/designing-porous-electronic-thin-film-devices-band-offsets-and-heteroepitaxy
#10
Keith T Butler, Christopher H Hendon, Aron Walsh
Increasing numbers of electrically active porous framework materials are being reported, with conductivities that make them attractive for technological applications. As design strategies for efficient carrier transport emerge, the next challenge is to incorporate the materials into a functioning device. In thin-film devices interface effects are of critical importance to overall function. In this article we present a method to identify compatible materials combinations to achieve mechanically robust, electronically optimal pairings...
June 16, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28620190/formation-of-biphasic-hydroxylapatite-beta-magnesium-tricalcium-phosphate-in-heat-treated-salmonid-vertebrae
#11
Don H Butler, Ruth Shahack-Gross
Ichthyoarchaeological evidence is uncommon at ancient hunter-gatherer sites from various regions and timeframes. This research contributes to the development of microarchaeological techniques useful for identifying fishing economies in situations where classifiable bones are unavailable. Specifically, traces of heat altered bone mineral in domestic hearths are expected to provide markers for discarded fish remains. We used a series of laboratory incineration experiments to characterize the mineralogy of burned salmonid vertebrae...
June 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28619805/complete-genome-sequences-of-two-human-oral-microbiome-commensals-streptococcus-salivarius-atcc-25975-and-s-salivarius-atcc-27945
#12
Robert R Butler, Jahna T A Soomer-James, Michel Frenette, Jean-François Pombert
Streptococcus salivarius strains are significant contributors to the human oral microbiome. Some possess unique fimbriae that give them the ability to coaggregate and colonize particular oral structures. We present here the complete genomes of Streptococcus salivarius Lancefield K(-)/K(+) strains ATCC 25975 and ATCC 27945, which can and cannot, respectively, produce fimbriae.
June 15, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28619778/in-patients-with-severe-uncontrolled-asthma-does-knowledge-of-adherence-and-inhaler-technique-using-electronic-monitoring-improve-clinical-decision-making-a-protocol-for-a-randomised-controlled-trial
#13
Matshediso C Mokoka, Lorna Lombard, Elaine M MacHale, Joanne Walsh, Breda Cushen, Imran Sulaiman, Damien Mc Carthy, Fiona Boland, Frank Doyle, Eoin Hunt, Desmond M Murphy, John Faul, Marcus Butler, Kathy Hetherington, J Mark FitzGerald, Job Fm van Boven, Liam G Heaney, Richard B Reilly, Richard W Costello
INTRODUCTION: Many patients with asthma remain poorly controlled despite the use of inhaled corticosteroids and long-acting beta agonists. Poor control may arise from inadequate adherence, incorrect inhaler technique or because the condition is refractory. Without having an objective assessment of adherence, clinicians may inadvertently add extra medication instead of addressing adherence. This study aims to assess if incorporating objectively recorded adherence from the Inhaler Compliance Assessment (INCA) device and lung function into clinical decision making provides more cost-effective prescribing and improves outcomes...
June 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28619659/effects-of-canagliflozin-on-cardiovascular-biomarkers-in-older-adults-with-type-2-diabetes
#14
James L Januzzi, Javed Butler, Petr Jarolim, Naveed Sattar, Ujjwala Vijapurkar, Mehul Desai, Michael J Davies
BACKGROUND: Sodium glucose co-transporter 2 (SGLT2) inhibitors may reduce cardiovascular and heart failure risk in patients with type 2 diabetes mellitus (T2DM). OBJECTIVES: To examine the effects of canagliflozin on cardiovascular biomarkers in older patients with T2DM. METHODS: In 666 T2DM patients randomized to receive canagliflozin 100 or 300 mg or placebo, we assessed median percent change in serum N-terminal pro-B type natriuretic peptide (NT-proBNP), high-sensitivity troponin I (hsTnI) , soluble (s)ST2, and galectin-3 from baseline to 26, 52, and 104 weeks...
June 9, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28619119/transmission-of-a-novel-sonotubometry-acoustic-click-stimulus-in-healthy-and-patulous-eustachian-tube-subjects-a-retrospective-case-control-study
#15
Justin M Pyne, Yaw Amoako-Tuffour, Guy Earle, Graham McIntyre, Michael B Butler, Manohar Bance
BACKGROUND: Eustachian tube (ET) dysfunction can be very difficult to diagnose accurately. Our aim is to determine whether a newly developed sonotubometric test using clicks can reliably detect ET opening during swallowing in normal ET subjects, and patulous ET (PET) in subjects with ET dysfunction. METHODS: Sixteen subjects (19 normal ET ears and 6 PET ears) were individually placed in a sound-isolated audiometry booth and subjected to a 1000Hz click train stimulus, played through the nose...
June 15, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28616546/late-gadolinium-enhancement-does-occur-in-tako-tsubo-cardiomyopathy-a-quantitative-cardiac-magnetic-resonance-and-speckle-tracking-strain-study
#16
Niranjan Gaikwad, Thomas Butler, Ryan Maxwell, Elizabeth Shaw, Wendy E Strugnell, Jonathan Chan, Gemma A Figtree, Richard E Slaughter, Christian Hamilton-Craig
BACKGROUND: Late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR) has been recommended to distinguish Tako-tsubo cardiomyopathy (TTC) from either acute myocardial infarction or myocarditis. METHOD: 44 consecutive patients with confirmed Mayo Clinic criteria for TTC underwent CMR imaging at 1.5 Tesla during the acute phase. 10 patients who had CMRI to exclude scar related ventricular tachycardia, and had negative studies, were used as negative controls...
September 2016: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/28616506/the-hookworm-ancylostoma-ceylanicum-an-emerging-public-health-risk-in-australian-tropical-rainforests-and-indigenous-communities
#17
Felicity A Smout, Lee F Skerratt, James R A Butler, Christopher N Johnson, Bradley C Congdon, R C Andrew Thompson
Ancylostoma ceylanicum is the common hookworm of domestic dogs and cats throughout Asia, and is an emerging but little understood public health risk in tropical northern Australia. We investigated the prevalence of A. ceylanicum in soil and free-ranging domestic dogs at six rainforest locations in Far North Queensland that are Indigenous Australian communities and popular tourist attractions within the Wet Tropics World Heritage Area. By combining PCR-based techniques with traditional methods of hookworm species identification, we found the prevalence of hookworm in Indigenous community dogs was high (96...
June 2017: One Health
https://www.readbyqxmd.com/read/28615469/is-this-the-carbapenemase-test-we-ve-been-waiting-for-a-multi-center-evaluation-of-the-modified-carbapenem-inactivation-method-mcim
#18
Susan M Butler-Wu, April N Abbott
A plethora of phenotypic methods exist for the detection of carbapenemases, however, clinical laboratories have struggled for years with accurate, objective phenotypic detection of carbapenemase activity in Enterobacteriaceae In this issue of the Journal of Clinical Microbiology, V. M. Pierce et al. (J Clin Microbiol 55:XXX-XXX, 2017, https://doi.org/10.1128/JCM.00193-17) report on a multicenter evaluation of the modified carbapenem inactivation method (mCIM). The high sensitivity, specificity, reproducibility and ease of interpretation associated with mCIM for Enterobacteriaceae will likely lead to its adoption by clinical laboratories...
June 14, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28615388/d%C3%A3-pistage-de-l%C3%A2-atr%C3%A3-sie-des-voies-biliaires-c%C3%A2-est-dans-les-cartes
#19
Richard A Schreiber, Alison Butler
No abstract text is available yet for this article.
June 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28615387/screening-for-biliary-atresia-it-s-in-the-cards
#20
Richard A Schreiber, Alison Butler
No abstract text is available yet for this article.
June 2017: Canadian Family Physician Médecin de Famille Canadien
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