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liver cancer perfusion

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https://www.readbyqxmd.com/read/27805597/study-of-viral-vectors-in-a-three-dimensional-liver-model-repopulated-with-the-human-hepatocellular-carcinoma-cell-line-hepg2
#1
Thomas Hiller, Viola Röhrs, Eva-Maria Dehne, Anke Wagner, Henry Fechner, Roland Lauster, Jens Kurreck
This protocol describes the generation of a three-dimensional (3D) ex vivo liver model and its application to the study and development of viral vector systems. The model is obtained by repopulating the extracellular matrix of a decellularized rat liver with a human hepatocyte cell line. The model permits studies in a vascularized 3D cell system, replacing potentially harmful experiments with living animals. Another advantage is the humanized nature of the model, which is closer to human physiology than animal models...
October 24, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27798773/chemosaturation-percutaneous-hepatic-perfusion-a-systematic-review
#2
REVIEW
Arndt Vogel, Sanjay Gupta, Martin Zeile, Rebecca von Haken, Roland Brüning, Gösta Lotz, Alexander Vahrmeijer, Thomas Vogl, Frank Wacker
: The Hepatic CHEMOSAT(®) Delivery System is an innovative medical device for the treatment of patients with unresectable primary liver tumors or unresectable hepatic metastases from solid organ malignancies. This system is used to perform chemosaturation percutaneous hepatic perfusion (CS-PHP), a procedure in which a high dose of the chemotherapeutic agent melphalan is delivered directly to the liver while limiting systemic exposure. In a clinical trial program, CS-PHP with melphalan significantly improved hepatic progression-free survival in patients with unresectable hepatic metastases from ocular or cutaneous melanoma...
October 31, 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27776665/image-quality-of-mean-temporal-arterial-and-mean-temporal-portal-venous-phase-images-calculated-from-low-dose-dynamic-volume-perfusion-ct-datasets-in-patients-with-hepatocellular-carcinoma-and-pancreatic-cancer
#3
X Wang, T Henzler, J Gawlitza, S Diehl, T Wilhelm, S O Schoenberg, Z Y Jin, H D Xue, A Smakic
PURPOSE: Dynamic volume perfusion CT (dVPCT) provides valuable information on tissue perfusion in patients with hepatocellular carcinoma (HCC) and pancreatic cancer. However, currently dVPCT is often performed in addition to conventional CT acquisitions due to the limited morphologic image quality of dose optimized dVPCT protocols. The aim of this study was to prospectively compare objective and subjective image quality, lesion detectability and radiation dose between mean temporal arterial (mTA) and mean temporal portal venous (mTPV) images calculated from low dose dynamic volume perfusion CT (dVPCT) datasets with linearly blended 120-kVp arterial and portal venous datasets in patients with HCC and pancreatic cancer...
November 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27761819/assessing-the-histone-deacetylase-activity-of-sirt6-in-primary-murine-hepatocytes-via-proximity-ligation-assay
#4
Katharina Wolf, Susanne Strand
Generation of primary cell culture of hepatocytes by mouse liver perfusion (MLP) combines the advantages of in vivo and in vitro models. It provides hepatocytes that grow under physiological conditions in mice, with the genotype of the whole organism or a specific gene knockout. In contrast to immortalized cell cultures, primary murine hepatocytes (pmHep) are non-cancerous cells with a limited lifespan but still amenable to classical in vitro methods such as treatment with drugs, small molecule inhibitors, and agonistic/antagonistic antibodies of surface receptors as well as transfection...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27759566/reproducibility-and-variability-of-very-low-dose-hepatic-perfusion-ct-in-metastatic-liver-disease
#5
Osman Melih Topcuoğlu, Muşturay Karçaaltıncaba, Deniz Akata, Mustafa Nasuh Özmen
PURPOSE: We aimed to determine the intra- and interobserver agreement on the software analysis of very low dose hepatic perfusion CT (pCT). METHODS: A total of 53 pCT examinations were obtained from 21 patients (16 men, 5 women; mean age, 60.4 years) with proven liver metastasis from various primary cancers. The pCT examinations were analyzed by two readers independently and perfusion parameters were noted for whole liver, whole metastasis, metastasis wall, and normal-looking liver (liver tissue without metastasis) in regions of interest (ROIs)...
November 2016: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/27754848/nucleolin-targeting-impairs-the-progression-of-pancreatic-cancer-and-promotes-the-normalization-of-tumor-vasculature
#6
Maud-Emmanuelle Gilles, Federica Maione, Mélissande Cossutta, Gilles Carpentier, Laure Caruana, Sylvia Di Maria, Claire Houppe, Damien Destouches, Ksenya Shchors, Christopher Prochasson, Fabien Mongelard, Simona Lamba, Alberto Bardelli, Philippe Bouvet, Anne Couvelard, José Courty, Enrico Giraudo, Ilaria Cascone
Pancreatic cancer is a highly aggressive tumor, mostly resistant to the standard treatments. Nucleolin (NCL) is overexpressed in cancers and its inhibition impairs tumor growth. Herein we showed that NCL was overexpressed in human specimens of pancreatic ductal adenocarcinoma (PDAC) and that the overall survival significantly increased in patients with low levels of NCL. The NCL antagonist N6L strongly impaired the growth of primary tumors and liver metastasis in an orthotopic mouse model of PDAC (mPDAC). Similar anti-tumor effect of N6L has been observed in a highly angiogenic mouse model of pancreatic neuroendocrine tumor RIP-Tag2...
October 17, 2016: Cancer Research
https://www.readbyqxmd.com/read/27744175/poor-and-enantioselective-bioavailability-of-naftopidil-enantiomers-is-due-to-extensive-and-stereoselective-metabolism-in-rat-liver
#7
Xiawen Liu, Lijun Zhu, Biyun Huang, Junjun Huang, Yi Cai, Liu Zhu, Bo Wu, Xiaojing Fu, Xingfei Zhang, Yi Rong, Qing Xiao, Jiewen Guo, Arong Li, Yifei Guo, Mu Yuan
Racemic naftopidil (NAF) is used to treat benign prostatic hyperplasia (BPH) and prostatic cancer (PCa). It exhibits greater efficacy but requires higher dose than other ɑ1-adrenoceptor blockers because of its poor bioavailability. It was previously shown that bioavailability of S(-)-NAF (14.5%) was twice that of R(+)-NAF (6.8%). The present study aimed to elucidate the major factors contributing to the poor and enantioselective bioavailability of NAF. First, absorption of NAF enantiomers was examined using a perfusated intestinal model...
September 27, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27733559/anti-vegf-therapy-induces-ecm-remodeling-and-mechanical-barriers-to-therapy-in-colorectal-cancer-liver-metastases
#8
Nuh N Rahbari, Dmitriy Kedrin, Joao Incio, Hao Liu, William W Ho, Hadi T Nia, Christina M Edrich, Keehoon Jung, Julien Daubriac, Ivy Chen, Takahiro Heishi, John D Martin, Yuhui Huang, Nir Maimon, Christoph Reissfelder, Jurgen Weitz, Yves Boucher, Jeffrey W Clark, Alan J Grodzinsky, Dan G Duda, Rakesh K Jain, Dai Fukumura
The survival benefit of anti-vascular endothelial growth factor (VEGF) therapy in metastatic colorectal cancer (mCRC) patients is limited to a few months because of acquired resistance. We show that anti-VEGF therapy induced remodeling of the extracellular matrix with subsequent alteration of the physical properties of colorectal liver metastases. Preoperative treatment with bevacizumab in patients with colorectal liver metastases increased hyaluronic acid (HA) deposition within the tumors. Moreover, in two syngeneic mouse models of CRC metastasis in the liver, we show that anti-VEGF therapy markedly increased the expression of HA and sulfated glycosaminoglycans (sGAGs), without significantly changing collagen deposition...
October 12, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27698722/analysis-of-the-first-therapeutic-target-achieving-time-of-warfarin-therapy-and-associated-factors-in-patients-with-pulmonary-embolism
#9
Xiaowei Gong, Haiyan Wang, Yadong Yuan
The present study aimed to investigate the factors affecting the first therapeutic-target-achieving (TTA) time of warfarin therapy in patients with acute pulmonary embolism (PTE). Between January 2008 and June 2013, patients with PTE confirmed by transpulmonary arterial enhanced computed tomographic pulmonary angiography or pulmonary ventilation perfusion scanning were included in the present study. Data collected included demographic information, history of tobacco and alcohol intake, basic diseases (stable and unstable hypertension, diabetes, heart failure, cancer/cerebral infarction, old myocardial infarction and atrial fibrillation), liver and kidney function, the haemoglobin and platelet count of the blood, international normalized ratio monitoring, warfarin dosage adjustment and medication combinations...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27601143/changes-in-hepatic-perfusion-assessed-by-dynamic-contrast-enhanced-mri-associated-with-morphologic-evaluation-in-patients-with-liver-metastases-from-colorectal-cancer-treated-with-first-line-chemotherapy
#10
Marco Tampellini, Dario Gned, Chiara Baratelli, Maria Pia Brizzi, Azzurra Ottone, Irene Alabiso, Chiara Bertaggia, Massimo Di Maio, Giorgio Vittorio Scagliotti, Andrea Veltri
INTRODUCTION: Blood perfusion of liver metastases can be non-invasively assessed by dynamic contrast enhanced magnetic resonance imaging (DCE-MRI). The aim of this study was to explore whether the ratio of hepatic arterial to total liver blood flow (Hepatic Perfusion Index-HPI) and the area under the enhancement curve (AUC) of selected liver areas in patients with hepatic metastases from colorectal cancer treated with first-line chemotherapy could predict response and/or be a prognostic variable...
September 6, 2016: La Radiologia Medica
https://www.readbyqxmd.com/read/27513071/isolated-hypoxic-hepatic-perfusion-with-high-dose-chemotherapy-in-patients-with-unresectable-liver-metastases-of-uveal-melanoma-results-from-two-experienced-centres
#11
Eleonora M de Leede, Mark C Burgmans, Ellen Kapiteijn, Gre P M Luyten, Martine J Jager, Fred G J Tijl, Henk H Hartgrink, Dirk J Grünhagen, Joost Rothbarth, Cornelis J H van de Velde, Cornelis Verhoef, Alexander L Vahrmeijer
Uveal melanoma patients have a poor survival after the diagnosis of metastatic disease. Isolated hepatic perfusion (IHP) was developed to treat patients with unresectable metastases confined to the liver. This retrospective analysis focuses on treatment characteristics, complications, toxicity and survival after IHP. Patients with uveal melanoma metastases confined to the liver treated with IHP in two experienced hepato-pancreatic-biliary surgery centres (Erasmus MC Cancer Institute and Leiden University Medical Center) were included...
August 10, 2016: Melanoma Research
https://www.readbyqxmd.com/read/27501370/percutaneous-hepatic-perfusion-php-with-melphalan-as-a-treatment-for-unresectable-metastases-confined-to-the-liver
#12
Eleonora M de Leede, Mark C Burgmans, Christian H Martini, Fred G J Tijl, Arian R van Erkel, Jaap Vuyk, Ellen Kapiteijn, Cornelis Verhoef, Cornelis J H van de Velde, Alexander L Vahrmeijer
Unresectable liver metastases of colorectal cancer can be treated with systemic chemotherapy, aiming to limit the disease, extend survival or turn unresectable metastases into resectable ones. Some patients however, suffer from side effects or progression under systemic treatment. For patients with metastasized uveal melanoma there are no standard systemic therapy options. For patients without extrahepatic disease, isolated liver perfusion (IHP) may enable local disease control with limited systemic side effects...
2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27493949/effects-of-platelet-derived-endothelial-cell-growth-factor-and-doppler-perfusion-index-in-patients-with-colorectal-hepatic-metastases
#13
Xueming Jiang, Zhixiang Zhang, Na Zhao, Xianghui He, Hao Guo
BACKGROUND: We aimed to find out if there is a correlation between Doppler perfusion index (DPI) and platelet- derived endothelial cell growth factor (PD-ECGF), which is an angiogenic factor with angiopoietic function, in patients with colorectal carcinoma. METHODS: 50 colorectal carcinoma patients (22 cases with liver metastases, 28 cases without liver metastases) and 50 healthy controls were assessed with Doppler ultrasound as a preoperative evaluation. PD-ECGF expression in postoperative specimens of the 50 cases with colorectal carcinoma was assayed by immunohistochemistry and real-time polymerase chain reaction methods...
June 2016: Visceral Medicine
https://www.readbyqxmd.com/read/27465664/design-synthesis-and-negative-inotropic-evaluation-of-4-phenyl-1h-1-2-4-triazol-5-4h-one-derivatives-containing-triazole-or-piperazine-moieties
#14
Zhi-Yu Wei, Bai-Ri Cui, Xun Cui, Yan-Ling Wu, Yang Fu, Li-Ping Liu, Hu-Ri Piao
In the present study, four novel series of 4-phenyl-1H-1,2,4-triazol-5(4H)-one derivatives containing triazole or piperazine moieties were designed, synthesized and evaluated for negative inotropic activity by measuring the left atrium stroke volume in isolated rabbit heart preparations. Almost all of the compounds showed an ability to moderate the cardiac workload by decreasing the heart rate and contractility. Among them, 7h was found to be the most potent with a change in stroke volume of -48.22 ± 0.36% at a concentration of 3×10(-5) mol/L (metoprolol: -9...
July 28, 2016: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/27462163/the-value-of-intravoxel-incoherent-motion-model-based-diffusion-weighted-imaging-for-outcome-prediction-in-resin-based-radioembolization-of-breast-cancer-liver-metastases
#15
Claus Christian Pieper, Carsten Meyer, Alois Martin Sprinkart, Wolfgang Block, Hojjat Ahmadzadehfar, Hans Heinz Schild, Petra Mürtz, Guido Matthias Kukuk
PURPOSE: To evaluate prognostic values of clinical and diffusion-weighted magnetic resonance imaging-derived intravoxel incoherent motion (IVIM) parameters in patients undergoing primary radioembolization for metastatic breast cancer liver metastases. SUBJECTS AND METHODS: A total of 21 females (mean age 54 years, range 43-72 years) with liver-dominant metastatic breast cancer underwent standard liver magnetic resonance imaging (1.5 T, diffusion-weighted imaging with b-values of 0, 50, and 800 s/mm(2)) before and 4-6 weeks after radioembolization...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27438262/investigating-nonalcoholic-fatty-liver-disease-in-a-liver-on-a-chip-microfluidic-device
#16
Manuele Gori, Maria Chiara Simonelli, Sara Maria Giannitelli, Luca Businaro, Marcella Trombetta, Alberto Rainer
BACKGROUND AND AIM: Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease worldwide, ranging from simple steatosis to nonalcoholic steatohepatitis, which may progress to cirrhosis, eventually leading to hepatocellular carcinoma (HCC). HCC ranks as the third highest cause of cancer-related death globally, requiring an early diagnosis of NAFLD as a potential risk factor. However, the molecular mechanisms underlying NAFLD are still under investigation. So far, many in vitro studies on NAFLD have been hampered by the limitations of 2D culture systems, in which cells rapidly lose tissue-specific functions...
2016: PloS One
https://www.readbyqxmd.com/read/27402526/intravoxel-incoherent-motion-diffusion-weighted-mr-imaging-for-prediction-of-early-arterial-blood-flow-stasis-in-radioembolization-of-breast-cancer-liver-metastases
#17
Claus Christian Pieper, Winfried Albert Willinek, Carsten Meyer, Hojjat Ahmadzadehfar, Guido Matthias Kukuk, Alois Martin Sprinkart, Wolfgang Block, Hans Heinz Schild, Petra Mürtz
PURPOSE: To retrospectively evaluate predictive value of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) for early arterial blood flow stasis during transarterial radioembolization (TARE) of liver dominant breast metastases (LdBM). MATERIALS AND METHODS: Preinterventional 1.5T DWI (b0, b1, b2 = 0, 50, 800 s/mm(2)) data for 28 liver lobes of 18 female patients treated by resin-based radioembolization (10 bilobar and 8 unilobar treatments) were analyzed...
September 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27303858/diffusion-related-mri-parameters-for-assessing-early-treatment-response-of-liver-metastases-to-cytotoxic-therapy-in-colorectal-cancer
#18
Jung Hoon Kim, Ijin Joo, Tae-Yong Kim, Sae-Won Han, Yong Jae Kim, Jeong Min Lee, Joon Koo Han
OBJECTIVE: The objective of our study was to evaluate early therapeutic response after cytotoxic chemotherapy in patients with liver metastasis from colorectal cancer (CRC) using intravoxel incoherent motion (IVIM) DWI and dynamic contrast-enhanced MRI (DCE-MRI). SUBJECTS AND METHODS: Nineteen patients with liver metastasis from CRC underwent DCE-MRI and IVIM DWI at baseline and after the first cycle of chemotherapy. IVIM DWI parameters including the apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudodiffusion coefficient (D*), and perfusion fraction (f) and DCE-MRI perfusion parameters including the volume transfer constant (K(trans)), reverse volume transfer constant (Kep), extravascular extracellular volume fraction (Ve), and initial area under the concentration curve in 60 seconds (iAUC) were calculated...
September 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27230652/pathological-complete-response-after-percutaneous-isolated-hepatic-perfusion-in-hepatocellular-carcinoma-with-portal-vein-tumor-thrombosis-a-case-report
#19
Keisuke Arai, Takumi Fukumoto, Motofumi Tanaka, Kaori Kuramitsu, Masahiro Kido, Hisoka Kinoshita, Taku Matsumoto, Hirochika Toyama, Sadaki Asari, Tadahiro Goto, Tetsuo Ajiki, Yonson Ku
BACKGROUND: Although the effectiveness of perioperative adjuvant therapy in the treatment of hepatocellular carcinoma (HCC) has been investigated, the efficacy of preoperative therapy is unclear. Herein, we report a case of pathological complete response after percutaneous isolated hepatic perfusion (PIHP) for HCC involving portal vein tumor thrombosis (PVTT). CASE PRESENTATION: A 77-year-old woman was referred to our institute with a liver mass detected on a routine health screening...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27195474/multiparametric-human-hepatocellular-carcinoma-characterization-and-therapy-response-evaluation-by-hyperpolarized-13-c-mrsi
#20
Stephan Düwel, Markus Durst, Concetta V Gringeri, Yvonne Kosanke, Claudia Gross, Martin A Janich, Axel Haase, Steffen J Glaser, Markus Schwaiger, Rolf F Schulte, Rickmer Braren, Marion I Menzel
Individual tumor characterization and treatment response monitoring based on current medical imaging methods remain challenging. This work investigates hyperpolarized (13) C compounds in an orthotopic rat hepatocellular carcinoma (HCC) model system before and after transcatheter arterial embolization (TAE). HCC ranks amongst the top six most common cancer types in humans and accounts for one-third of cancer-related deaths worldwide. Early therapy response monitoring could aid in the development of personalized therapy approaches and novel therapeutic concepts...
July 2016: NMR in Biomedicine
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