Se-Hyung Park, Robert N Helsley, Taghreed Fadhul, Jennifer L S Willoughby, Leila Noetzli, Ho-Chou Tu, Marie H Solheim, Shiho Fujisaka, Hui Pan, Jonathan M Dreyfuss, Joanna Bons, Jacob Rose, Christina D King, Birgit Schilling, Aldons J Lusis, Calvin Pan, Manoj Gupta, Rohit N Kulkarni, Kevin Fitzgerald, Philip A Kern, Senad Divanovic, C Ronald Kahn, Samir Softic
Non-alcoholic fatty liver disease (NAFLD) is a liver manifestation of metabolic syndrome, and is estimated to affect one billion individuals worldwide. An increased intake of a high-fat diet (HFD) and sugar-sweetened beverages are risk-factors for NAFLD development, but how their combined intake promotes progression to a more severe form of liver injury is unknown. Here we show that fructose metabolism via ketohexokinase (KHK) C isoform leads to unresolved endoplasmic reticulum (ER) stress when coupled with a HFD intake...
May 23, 2023: Metabolism: Clinical and Experimental